CA2501381A1 - Method of administering bisphosphonates - Google Patents
Method of administering bisphosphonates Download PDFInfo
- Publication number
- CA2501381A1 CA2501381A1 CA002501381A CA2501381A CA2501381A1 CA 2501381 A1 CA2501381 A1 CA 2501381A1 CA 002501381 A CA002501381 A CA 002501381A CA 2501381 A CA2501381 A CA 2501381A CA 2501381 A1 CA2501381 A1 CA 2501381A1
- Authority
- CA
- Canada
- Prior art keywords
- bisphosphonate
- months
- acid
- alkyl
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940122361 Bisphosphonate Drugs 0.000 title claims abstract description 51
- 150000004663 bisphosphonates Chemical class 0.000 title claims abstract description 44
- 238000000034 method Methods 0.000 title claims description 11
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- 229960004276 zoledronic acid Drugs 0.000 claims abstract description 15
- 150000003839 salts Chemical class 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- -1 4H-1,2,4-triazolyl Chemical group 0.000 claims description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 14
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000003277 amino group Chemical group 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 125000004414 alkyl thio group Chemical group 0.000 claims description 4
- 125000001589 carboacyl group Chemical group 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 125000002883 imidazolyl group Chemical group 0.000 claims description 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 3
- 125000002971 oxazolyl group Chemical group 0.000 claims description 3
- 125000000335 thiazolyl group Chemical group 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41855502P | 2002-10-15 | 2002-10-15 | |
| US60/418,555 | 2002-10-15 | ||
| PCT/EP2003/011380 WO2004035061A1 (en) | 2002-10-15 | 2003-10-14 | Method of administering bisphosphonates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2501381A1 true CA2501381A1 (en) | 2004-04-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002501381A Abandoned CA2501381A1 (en) | 2002-10-15 | 2003-10-14 | Method of administering bisphosphonates |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20050272705A1 (enExample) |
| EP (1) | EP1553958A1 (enExample) |
| JP (1) | JP2006506365A (enExample) |
| CN (1) | CN1705485A (enExample) |
| AU (1) | AU2003280373A1 (enExample) |
| BR (1) | BR0315328A (enExample) |
| CA (1) | CA2501381A1 (enExample) |
| TW (1) | TW200410701A (enExample) |
| WO (1) | WO2004035061A1 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7361678B2 (en) | 2002-03-05 | 2008-04-22 | Transtech Pharma, Inc. | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents |
| AU2007212508A1 (en) * | 2006-02-06 | 2007-08-16 | Cypress Bioscience, Inc. | Compositions comprising a bisphosphonate and an antifolate |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| KR101813728B1 (ko) | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| CA2772797C (en) | 2009-09-30 | 2018-09-25 | Transtech Pharma, Inc. | Substituted imidazole derivatives |
| CN102190684A (zh) * | 2010-03-15 | 2011-09-21 | 南通波锐生物医药有限公司 | 一种具有药物应用的含磷化合物及其制备和用途 |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
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| KR102103214B1 (ko) | 2012-05-24 | 2020-04-22 | 다우 글로벌 테크놀로지스 엘엘씨 | 살미생물 조성물 |
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| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
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| US12285489B2 (en) * | 2018-06-26 | 2025-04-29 | Frank Hallock Ebetino | Bone targeted antimicrobial oxazolidinone related compounds, formulations thereof, and uses thereof |
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| RU2119794C1 (ru) * | 1992-06-30 | 1998-10-10 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Использование фосфонатов и нестероидных противовоспалительных лекарственных средств для лечения артрита, способ лечения |
| US6468559B1 (en) * | 2000-04-28 | 2002-10-22 | Lipocine, Inc. | Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods |
| SK287278B6 (sk) * | 2000-06-20 | 2010-05-07 | Novartis Ag | Použitie kyseliny 1-hydroxy-2-(imidazol-1-yl)etán-1,1- difosfónovej na prípravu liečiva na liečenie stavov abnormálne zvýšeného kostného obratu |
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- 2003-10-14 JP JP2004544227A patent/JP2006506365A/ja not_active Withdrawn
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| CN1705485A (zh) | 2005-12-07 |
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| BR0315328A (pt) | 2005-08-16 |
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| US20050272705A1 (en) | 2005-12-08 |
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