CA2490934C - Method for altering fatty acid composition of milk - Google Patents
Method for altering fatty acid composition of milk Download PDFInfo
- Publication number
- CA2490934C CA2490934C CA2490934A CA2490934A CA2490934C CA 2490934 C CA2490934 C CA 2490934C CA 2490934 A CA2490934 A CA 2490934A CA 2490934 A CA2490934 A CA 2490934A CA 2490934 C CA2490934 C CA 2490934C
- Authority
- CA
- Canada
- Prior art keywords
- milk
- casein
- fatty acids
- beta
- cows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 235000013336 milk Nutrition 0.000 title claims abstract description 125
- 210000004080 milk Anatomy 0.000 title claims abstract description 125
- 239000008267 milk Substances 0.000 title claims abstract description 125
- 238000000034 method Methods 0.000 title claims abstract description 28
- 235000014113 dietary fatty acids Nutrition 0.000 title description 31
- 229930195729 fatty acid Natural products 0.000 title description 29
- 239000000194 fatty acid Substances 0.000 title description 29
- 150000004665 fatty acids Chemical class 0.000 title description 29
- 239000000203 mixture Substances 0.000 title description 15
- 241000283690 Bos taurus Species 0.000 claims abstract description 53
- 150000004671 saturated fatty acids Chemical class 0.000 claims abstract description 39
- 235000003441 saturated fatty acids Nutrition 0.000 claims abstract description 38
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims abstract description 36
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims abstract description 36
- 239000005018 casein Substances 0.000 claims description 106
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 35
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 25
- 108090000623 proteins and genes Proteins 0.000 claims description 23
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 238000012360 testing method Methods 0.000 claims description 10
- 229940021722 caseins Drugs 0.000 claims description 8
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 7
- -1 hair Substances 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 210000004209 hair Anatomy 0.000 claims description 2
- 102000011632 Caseins Human genes 0.000 abstract description 11
- 108010076119 Caseins Proteins 0.000 abstract description 11
- 238000003205 genotyping method Methods 0.000 abstract description 7
- 229920006395 saturated elastomer Polymers 0.000 abstract description 3
- 125000000539 amino acid group Chemical group 0.000 abstract description 2
- 235000021247 β-casein Nutrition 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 description 35
- 244000144980 herd Species 0.000 description 26
- 239000000047 product Substances 0.000 description 20
- 108020004414 DNA Proteins 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 10
- 235000021240 caseins Nutrition 0.000 description 9
- 239000003925 fat Substances 0.000 description 9
- 235000019197 fats Nutrition 0.000 description 9
- 239000002773 nucleotide Substances 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 208000029078 coronary artery disease Diseases 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 230000011987 methylation Effects 0.000 description 5
- 238000007069 methylation reaction Methods 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Natural products NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 235000021243 milk fat Nutrition 0.000 description 4
- 229930024421 Adenine Natural products 0.000 description 3
- 229960000643 adenine Drugs 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- ADBHAJDGVKLXHK-UHFFFAOYSA-N Casomorphin Chemical compound CCC(C)C(C(O)=O)NC(=O)C1CCCN1C(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)C1N(CCC1)C(=O)C(N)CC=1C=CC(O)=CC=1)CC1=CC=CC=C1 ADBHAJDGVKLXHK-UHFFFAOYSA-N 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 230000000923 atherogenic effect Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 235000020247 cow milk Nutrition 0.000 description 2
- 229940104302 cytosine Drugs 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 235000013367 dietary fats Nutrition 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000021081 unsaturated fats Nutrition 0.000 description 2
- ITZMJCSORYKOSI-AJNGGQMLSA-N APGPR Enterostatin Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)CCC1 ITZMJCSORYKOSI-AJNGGQMLSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000012248 genetic selection Methods 0.000 description 1
- 230000007614 genetic variation Effects 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108010070701 procolipase Proteins 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/124—Animal traits, i.e. production traits, including athletic performance or the like
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Dairy Products (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZNZ520016 | 2002-07-03 | ||
| NZ52001602 | 2002-07-03 | ||
| PCT/NZ2003/000140 WO2004004450A1 (en) | 2002-07-03 | 2003-07-03 | Method for altering fatty acid composition of milk |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2490934A1 CA2490934A1 (en) | 2004-01-15 |
| CA2490934C true CA2490934C (en) | 2015-11-24 |
Family
ID=30113402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2490934A Expired - Lifetime CA2490934C (en) | 2002-07-03 | 2003-07-03 | Method for altering fatty acid composition of milk |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7851147B2 (enExample) |
| EP (1) | EP1538897A4 (enExample) |
| JP (3) | JP2005531325A (enExample) |
| KR (4) | KR20140056364A (enExample) |
| CN (1) | CN100400672C (enExample) |
| AU (1) | AU2003281273B2 (enExample) |
| CA (1) | CA2490934C (enExample) |
| NZ (1) | NZ538004A (enExample) |
| WO (1) | WO2004004450A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100674404B1 (ko) * | 2005-07-05 | 2007-01-29 | 재단법인서울대학교산학협력재단 | 탄소나노튜브가 코팅된 방열판 및 그 제조방법 |
| EP2121976A2 (en) * | 2007-02-15 | 2009-11-25 | Wageningen Universiteit | Method for selection of non-human mammal producing milk with improved fatty acid composition |
| US20100304353A1 (en) * | 2007-07-16 | 2010-12-02 | Pfizer Inc | Methods of improving a genomic marker index of dairy animals and products |
| CN101970688A (zh) * | 2007-09-12 | 2011-02-09 | 美国辉瑞有限公司 | 遗传标记和相关上位相互作用的使用方法 |
| AU2008343365A1 (en) * | 2007-12-17 | 2009-07-09 | Pfizer Inc. | Methods of improving genetic profiles of dairy animals and products |
| JP6866159B2 (ja) * | 2013-08-23 | 2021-04-28 | ズィ・エイツー・ミルク・カンパニー・リミテッド | ベータカゼインａ２および血中グルコースレベル |
| CN105018581A (zh) * | 2014-04-29 | 2015-11-04 | 上海桑尼生物科技有限公司 | 一种基于测序法检测β-酪蛋白基因型的方法 |
| EP3285795B1 (en) * | 2015-04-22 | 2022-11-16 | Cedars-Sinai Medical Center | Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes and obesity |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0832981A1 (en) * | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
| WO1993004171A1 (en) * | 1991-08-19 | 1993-03-04 | Symbicom Aktiebolag | Human beta-casein, process for producing it and use thereof |
| ATE442585T1 (de) | 1994-11-04 | 2009-09-15 | A2 Corp Ltd | Selektionsverfahren für nicht-diabetogene milch oder milchprodukte sowie hierdurch erfasste milch oder milchprodukte |
| US20020007497A1 (en) * | 1995-05-16 | 2002-01-17 | Stuart Mclachlan Corran Norman | Food product and process |
| US6570060B2 (en) * | 1995-05-16 | 2003-05-27 | Mclachlan Corran Norman Stuart | Milk lacking β-casein A1 |
| US7094949B2 (en) * | 1995-05-16 | 2006-08-22 | A2 Corporation Limited | Breeding and milking cows for milk free of β-casein A1 |
| WO1996036239A1 (en) | 1995-05-16 | 1996-11-21 | Corran Norman Stuart Mclachlan | Food product and process |
| EP1196047A4 (en) * | 1999-06-29 | 2004-12-22 | New Zealand Milk Inst Ltd | MILK-BASED PROPHYLACTIC FOOD SUPPLEMENTS |
| AU9037401A (en) * | 2000-09-08 | 2002-03-22 | New Zealand Dairy Board | Milk containing beta-casein with proline at position 67 does not aggravate neurological disorders |
| US20060280802A1 (en) * | 2002-10-04 | 2006-12-14 | Campbell Julie H | Therapeutic uses of beta-casein a2 and dietary supplement containing beta-casein a2 |
| US20060166244A1 (en) * | 2005-01-14 | 2006-07-27 | The University Of Missouri System | DNA markers for increased milk production in cattle |
-
2003
- 2003-07-03 KR KR1020147008052A patent/KR20140056364A/ko not_active Ceased
- 2003-07-03 US US10/519,624 patent/US7851147B2/en active Active
- 2003-07-03 EP EP03741684A patent/EP1538897A4/en not_active Ceased
- 2003-07-03 CN CNB038158086A patent/CN100400672C/zh not_active Expired - Lifetime
- 2003-07-03 CA CA2490934A patent/CA2490934C/en not_active Expired - Lifetime
- 2003-07-03 KR KR1020127002227A patent/KR20120028395A/ko not_active Ceased
- 2003-07-03 WO PCT/NZ2003/000140 patent/WO2004004450A1/en not_active Ceased
- 2003-07-03 NZ NZ538004A patent/NZ538004A/en not_active IP Right Cessation
- 2003-07-03 KR KR1020057000012A patent/KR20050060057A/ko not_active Ceased
- 2003-07-03 AU AU2003281273A patent/AU2003281273B2/en not_active Expired
- 2003-07-03 KR KR1020137003640A patent/KR20130020939A/ko not_active Ceased
- 2003-07-03 JP JP2004519389A patent/JP2005531325A/ja active Pending
-
2010
- 2010-03-02 JP JP2010045098A patent/JP5068833B2/ja not_active Expired - Lifetime
-
2012
- 2012-03-12 JP JP2012054371A patent/JP2012135320A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN100400672C (zh) | 2008-07-09 |
| JP2005531325A (ja) | 2005-10-20 |
| US7851147B2 (en) | 2010-12-14 |
| JP5068833B2 (ja) | 2012-11-07 |
| US20060094011A1 (en) | 2006-05-04 |
| JP2010162035A (ja) | 2010-07-29 |
| EP1538897A4 (en) | 2006-01-04 |
| AU2003281273B2 (en) | 2008-07-24 |
| JP2012135320A (ja) | 2012-07-19 |
| KR20120028395A (ko) | 2012-03-22 |
| WO2004004450A1 (en) | 2004-01-15 |
| AU2003281273A1 (en) | 2004-01-23 |
| KR20050060057A (ko) | 2005-06-21 |
| KR20130020939A (ko) | 2013-03-04 |
| HK1082901A1 (en) | 2006-06-23 |
| KR20140056364A (ko) | 2014-05-09 |
| NZ538004A (en) | 2011-01-28 |
| CA2490934A1 (en) | 2004-01-15 |
| CN1665386A (zh) | 2005-09-07 |
| EP1538897A1 (en) | 2005-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230704 |