CA2486490A1 - Polypeptides therapeutiques, acides nucleiques les codant et principes d'utilisation - Google Patents
Polypeptides therapeutiques, acides nucleiques les codant et principes d'utilisation Download PDFInfo
- Publication number
- CA2486490A1 CA2486490A1 CA002486490A CA2486490A CA2486490A1 CA 2486490 A1 CA2486490 A1 CA 2486490A1 CA 002486490 A CA002486490 A CA 002486490A CA 2486490 A CA2486490 A CA 2486490A CA 2486490 A1 CA2486490 A1 CA 2486490A1
- Authority
- CA
- Canada
- Prior art keywords
- nucleic acid
- polypeptide
- novx
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des séquences d'acides nucléiques qui codent de nouveaux polypeptides. L'invention concerne également des polypeptides codés par ces séquences d'acides nucléiques et des anticorps qui se lient par immunospécificité à ces polypeptides, ainsi que des dérivés, des variantes, des mutants ou des fragments des nouveaux polypeptides, polynucléotides ou anticorps spécifiques des polypeptides. L'invention concerne enfin des procédés thérapeutiques, de diagnostic et de recherche destinés au diagnostic, au traitement et à la prévention de troubles dans lesquels sont impliqués l'un ou l'autre des protéines et acides nucléiques humains de l'invention.
Applications Claiming Priority (43)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36549102P | 2002-03-19 | 2002-03-19 | |
US60/365,491 | 2002-03-19 | ||
US38550402P | 2002-06-04 | 2002-06-04 | |
US60/385,504 | 2002-06-04 | ||
US38604102P | 2002-06-05 | 2002-06-05 | |
US60/386,041 | 2002-06-05 | ||
US38697402P | 2002-06-06 | 2002-06-06 | |
US38645302P | 2002-06-06 | 2002-06-06 | |
US60/386,974 | 2002-06-06 | ||
US60/386,453 | 2002-06-06 | ||
US38681602P | 2002-06-07 | 2002-06-07 | |
US38700202P | 2002-06-07 | 2002-06-07 | |
US60/386,816 | 2002-06-07 | ||
US60/387,002 | 2002-06-07 | ||
US38754002P | 2002-06-10 | 2002-06-10 | |
US60/387,540 | 2002-06-10 | ||
US38765902P | 2002-06-11 | 2002-06-11 | |
US60/387,659 | 2002-06-11 | ||
US38793402P | 2002-06-12 | 2002-06-12 | |
US60/387,934 | 2002-06-12 | ||
US38912302P | 2002-06-13 | 2002-06-13 | |
US60/389,123 | 2002-06-13 | ||
US38972902P | 2002-06-17 | 2002-06-17 | |
US38974202P | 2002-06-17 | 2002-06-17 | |
US60/389,742 | 2002-06-17 | ||
US60/389,729 | 2002-06-17 | ||
US39000602P | 2002-06-19 | 2002-06-19 | |
US60/390,006 | 2002-06-19 | ||
US39670602P | 2002-07-17 | 2002-07-17 | |
US60/396,706 | 2002-07-17 | ||
US40283202P | 2002-08-12 | 2002-08-12 | |
US60/402,832 | 2002-08-12 | ||
US40348602P | 2002-08-13 | 2002-08-13 | |
US60/403,486 | 2002-08-13 | ||
US40352202P | 2002-08-14 | 2002-08-14 | |
US60/403,522 | 2002-08-14 | ||
US40374802P | 2002-08-15 | 2002-08-15 | |
US60/403,748 | 2002-08-15 | ||
US38703702P | 2002-11-06 | 2002-11-06 | |
US60/387,037 | 2002-11-06 | ||
US10/454,246 | 2003-06-03 | ||
US10/454,246 US20050053930A1 (en) | 2000-07-18 | 2003-06-03 | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
PCT/US2003/017512 WO2004000997A2 (fr) | 2002-03-19 | 2003-06-04 | Polypeptides therapeutiques, acides nucleiques les codant et principes d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2486490A1 true CA2486490A1 (fr) | 2003-12-31 |
Family
ID=34140035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002486490A Abandoned CA2486490A1 (fr) | 2002-03-19 | 2003-06-04 | Polypeptides therapeutiques, acides nucleiques les codant et principes d'utilisation |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2486490A1 (fr) |
WO (1) | WO2004000997A2 (fr) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1725249T3 (en) | 2003-11-06 | 2014-03-17 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugating to ligands. |
BRPI0510883B8 (pt) | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
EP1907580A2 (fr) * | 2005-07-28 | 2008-04-09 | Oncotherapy Science, Inc. | Procede pour le diagnostic et le traitement d'hypernephrome |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
EP2016394A4 (fr) | 2006-04-04 | 2013-04-24 | Singulex Inc | Procédés et compositions d'analyse extrêmement sensible de marqueurs et de détection de molécules |
EP2440936A4 (fr) | 2009-06-08 | 2013-03-13 | Singulex Inc | Groupes de biomarqueurs très sensibles |
EP2448966B1 (fr) | 2009-07-03 | 2018-11-14 | Avipep Pty Ltd | Immunoconjugués et leurs procédés de production |
IN2012DN03025A (fr) | 2009-09-09 | 2015-07-31 | Ct Se Llc | |
US9315581B2 (en) | 2009-12-23 | 2016-04-19 | A Vipep Pty Limited | Immuno-conjugates and methods for producing them |
US20130028917A1 (en) | 2010-04-15 | 2013-01-31 | Spirogen Developments Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
WO2011156328A1 (fr) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Anticorps et conjugués modifiés par la cystéine |
EP2640727B1 (fr) | 2010-11-17 | 2015-05-13 | Genentech, Inc. | Conjugués d'anticorps alaninyl-maytansinol |
CA2833404A1 (fr) | 2011-04-21 | 2012-10-26 | Garvan Institute Of Medical Research | Molecules a domaine variable modifie et procedes de preparation et d'utilisation de celles-ci |
JP5987053B2 (ja) | 2011-05-12 | 2016-09-06 | ジェネンテック, インコーポレイテッド | フレームワークシグネチャーペプチドを用いて動物サンプルにおける治療抗体を検出するための多重反応モニタリングlc−ms/ms法 |
AU2012322607B2 (en) | 2011-10-14 | 2017-02-16 | Genentech, Inc. | Pyrrolobenzodiazepines and conjugates thereof |
WO2013130093A1 (fr) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarqueurs pour un traitement à base de composés chimiothérapeutiques anti-tubuline |
LT2906253T (lt) | 2012-10-12 | 2018-10-10 | Adc Therapeutics Sa | Pirolobenzodiazepino-anti-psma antikūno konjugatas |
EP2906297B1 (fr) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Conjugués anticorps - pyrrolobenzodiazépine |
EP2906298B1 (fr) | 2012-10-12 | 2018-10-03 | ADC Therapeutics SA | Conjugués pyrrolobenzodiazépine-anticorps |
ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
ME03486B (fr) | 2012-10-12 | 2020-01-20 | Medimmune Ltd | Pyrrolobenzodiazépines et ses conjugués |
PT2906296T (pt) | 2012-10-12 | 2018-06-01 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina-anticorpo |
CA2887899C (fr) | 2012-10-12 | 2020-03-31 | Adc Therapeutics Sarl | Conjugues anticorps anti-cd22 - pyrrolobenzodiazepine |
EA031585B1 (ru) | 2012-12-21 | 2019-01-31 | Медимьюн Лимитед | Пирролобензодиазепины и их конъюгаты |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
CN105209077B (zh) | 2013-03-13 | 2019-06-11 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓以及其结合物 |
AR096287A1 (es) | 2013-03-13 | 2015-12-23 | Spirogen Sàrl | Pirrolobenzodiacepinas y conjugados |
CA2904044C (fr) | 2013-03-13 | 2020-03-31 | Medimmune Limited | Pyrrolobenzodiazepines et leurs conjugues |
US10442836B2 (en) | 2013-08-12 | 2019-10-15 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
WO2015052534A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépine |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP3054986B1 (fr) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Conjugués anticorps-pyrrolobenzodiazépine |
WO2015052532A1 (fr) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Conjugués anticorps-pyrrolobenzodiazépines |
MX2016007578A (es) | 2013-12-16 | 2016-10-03 | Genentech Inc | Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo [e] indol, y metodos de uso y tratamiento. |
MX2016007826A (es) | 2013-12-16 | 2017-03-31 | Genentech Inc | Compuestos peptidomimeticos y sus conjugados de anticuerpo-farmaco. |
BR112016012410A2 (pt) | 2013-12-16 | 2017-09-26 | Genentech Inc | conjugado de droga e anticorpo, composto conjugado de droga e anticorpo, composto não-peptídico, método de tratamento de doenças em seres humanos e composição farmacêutica |
US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CN107108724A (zh) | 2014-09-12 | 2017-08-29 | 豪夫迈·罗氏有限公司 | 半胱氨酸改造抗体和缀合物 |
WO2016040825A1 (fr) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés |
SG11201702079UA (en) | 2014-09-17 | 2017-04-27 | Genentech Inc | Pyrrolobenzodiazepines and antibody disulfide conjugates thereof |
CA2968447A1 (fr) | 2014-11-25 | 2016-06-02 | Adc Therapeutics Sa | Conjugues anticorps-pyrrolobenzodiazepine |
CA2969689A1 (fr) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Composes d'amine quaternaire et conjugues anticorps-medicament de ceux-ci |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
EP3433621A1 (fr) | 2016-03-25 | 2019-01-30 | H. Hoffnabb-La Roche Ag | Dosage multiplexé pour la quantification d'anticorps totaux et de médicaments conjugués à des anticorps |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
CN109313200B (zh) | 2016-05-27 | 2022-10-04 | 豪夫迈·罗氏有限公司 | 用于表征位点特异性抗体-药物缀合物的生物分析性方法 |
EP3464280B1 (fr) | 2016-06-06 | 2021-10-06 | F. Hoffmann-La Roche AG | Médicaments conjugués d'anticorps silvestrol et procédés d'utilisation |
JP7093767B2 (ja) | 2016-08-11 | 2022-06-30 | ジェネンテック, インコーポレイテッド | ピロロベンゾジアゼピンプロドラッグ及びその抗体コンジュゲート |
JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
KR20200032243A (ko) | 2017-02-08 | 2020-03-25 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
PT3612537T (pt) | 2017-04-18 | 2022-08-29 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina |
EP3612234B1 (fr) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Polythérapie avec un conjugué anticorps anti-axl-médicament |
UA127900C2 (uk) | 2017-06-14 | 2024-02-07 | Ейдісі Терапьютікс Са | Схема дозування для введення adc до cd19 |
DK3668874T3 (da) | 2017-08-18 | 2022-02-14 | Medimmune Ltd | Pyrrolobenzodiazepin-konjugater |
RU2020113749A (ru) | 2017-09-20 | 2021-10-20 | пиЭйч ФАРМА Ко., ЛТД. | Аналоги таиланстатина |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
TW202037381A (zh) | 2018-10-24 | 2020-10-16 | 瑞士商赫孚孟拉羅股份公司 | 綴合化學降解誘導劑及使用方法 |
WO2020123275A1 (fr) | 2018-12-10 | 2020-06-18 | Genentech, Inc. | Peptides de photoréticulation pour conjugaison spécifique de site à des protéines contenant fc |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6210939B1 (en) * | 1993-10-25 | 2001-04-03 | Canji, Inc. | Recombinant adenoviral vector and methods of use |
-
2003
- 2003-06-04 CA CA002486490A patent/CA2486490A1/fr not_active Abandoned
- 2003-06-04 WO PCT/US2003/017512 patent/WO2004000997A2/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2004000997A2 (fr) | 2003-12-31 |
WO2004000997A3 (fr) | 2007-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |