CA2481665A1 - Automatic point source biological agent detection system - Google Patents
Automatic point source biological agent detection system Download PDFInfo
- Publication number
- CA2481665A1 CA2481665A1 CA002481665A CA2481665A CA2481665A1 CA 2481665 A1 CA2481665 A1 CA 2481665A1 CA 002481665 A CA002481665 A CA 002481665A CA 2481665 A CA2481665 A CA 2481665A CA 2481665 A1 CA2481665 A1 CA 2481665A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- biological agent
- aerosol
- identifier
- cartridge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003124 biologic agent Substances 0.000 title claims abstract description 36
- 238000001514 detection method Methods 0.000 title claims description 37
- 238000012360 testing method Methods 0.000 claims abstract description 59
- 238000003752 polymerase chain reaction Methods 0.000 claims abstract description 58
- 239000002245 particle Substances 0.000 claims abstract description 53
- 239000007788 liquid Substances 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 40
- 238000004458 analytical method Methods 0.000 claims abstract description 25
- 238000012545 processing Methods 0.000 claims abstract description 24
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 239000000443 aerosol Substances 0.000 claims description 34
- 238000012216 screening Methods 0.000 claims description 17
- 239000012636 effector Substances 0.000 claims description 12
- 238000003556 assay Methods 0.000 claims description 11
- 238000003860 storage Methods 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 3
- 230000007246 mechanism Effects 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 239000012530 fluid Substances 0.000 abstract description 20
- 238000012546 transfer Methods 0.000 abstract description 14
- 241000193738 Bacillus anthracis Species 0.000 abstract description 13
- 229940065181 bacillus anthracis Drugs 0.000 abstract description 13
- 238000005516 engineering process Methods 0.000 abstract description 9
- 238000010222 PCR analysis Methods 0.000 abstract description 6
- 238000012790 confirmation Methods 0.000 abstract description 4
- 238000001914 filtration Methods 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract description 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
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- 108020004414 DNA Proteins 0.000 description 14
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- 210000004215 spore Anatomy 0.000 description 9
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- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 244000052769 pathogen Species 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
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- 239000012807 PCR reagent Substances 0.000 description 2
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- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
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- 239000011534 wash buffer Substances 0.000 description 2
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- 230000005653 Brownian motion process Effects 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
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- 230000002068 genetic effect Effects 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
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- 239000004021 humic acid Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 239000013642 negative control Substances 0.000 description 1
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- 238000000746 purification Methods 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00871—Communications between instruments or with remote terminals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/2273—Atmospheric sampling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/2202—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling
- G01N1/2211—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling with cyclones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/24—Suction devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/022—Devices for withdrawing samples sampling for security purposes, e.g. contraband, warfare agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/022—Devices for withdrawing samples sampling for security purposes, e.g. contraband, warfare agents
- G01N2001/025—Devices for withdrawing samples sampling for security purposes, e.g. contraband, warfare agents postal items
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/2202—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling
- G01N1/2214—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling by sorption
- G01N2001/2217—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling by sorption using a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00871—Communications between instruments or with remote terminals
- G01N2035/00881—Communications between instruments or with remote terminals network configurations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Clinical Laboratory Science (AREA)
- Robotics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Hydrology & Water Resources (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38135102P | 2002-05-20 | 2002-05-20 | |
| US60/381,351 | 2002-05-20 | ||
| PCT/US2003/015737 WO2003100382A1 (en) | 2002-05-20 | 2003-05-20 | Automatic point source biological agent detection system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2481665A1 true CA2481665A1 (en) | 2003-12-04 |
Family
ID=29584309
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002481665A Abandoned CA2481665A1 (en) | 2002-05-20 | 2003-05-20 | Automatic point source biological agent detection system |
| CA002482031A Abandoned CA2482031A1 (en) | 2002-05-20 | 2003-05-20 | Point source biological agent detection system |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002482031A Abandoned CA2482031A1 (en) | 2002-05-20 | 2003-05-20 | Point source biological agent detection system |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20040063197A1 (enExample) |
| EP (2) | EP1508024A1 (enExample) |
| JP (2) | JP2005526977A (enExample) |
| KR (2) | KR20050084787A (enExample) |
| AU (2) | AU2003285852B2 (enExample) |
| CA (2) | CA2481665A1 (enExample) |
| IL (2) | IL164321A0 (enExample) |
| RU (2) | RU2316748C2 (enExample) |
| WO (2) | WO2004018704A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8173431B1 (en) | 1998-11-13 | 2012-05-08 | Flir Systems, Inc. | Mail screening to detect mail contaminated with biological harmful substances |
| US6765490B2 (en) | 2001-10-23 | 2004-07-20 | Steven W. Lopez | System and methods for detecting harmful agents within contents of mail |
| US7574930B2 (en) * | 2002-02-15 | 2009-08-18 | Implant Sciences Corporation | Trace chemical sensing |
| US7100422B2 (en) * | 2002-05-31 | 2006-09-05 | Drs Sustainment Systems, Inc. | Systems and methods for residue collection with improved letter handling capability |
| CA2488049C (en) * | 2002-05-31 | 2011-09-20 | Engineered Support Systems, Inc. | Systems and methods for residue collection |
| US7170023B1 (en) * | 2003-11-06 | 2007-01-30 | United Services Automobile Associaton (Usaa) | System and method for processing mail |
| WO2005078674A2 (en) * | 2003-12-10 | 2005-08-25 | Smiths Detection Inc. | Autonomous surveillance system |
| DE102004021822B3 (de) * | 2004-04-30 | 2005-11-17 | Siemens Ag | Verfahren und Anordnung zur DNA-Amplifikation mittels PCR unter Einsatz von Trockenreagenzien |
| DE102004021780B4 (de) * | 2004-04-30 | 2008-10-02 | Siemens Ag | Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien |
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US7837937B2 (en) | 2004-07-09 | 2010-11-23 | Hamilton Sundstrand Corporation | Biological agent detector |
| EP2314688B1 (en) | 2004-11-12 | 2014-07-16 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| US7738100B2 (en) * | 2005-07-21 | 2010-06-15 | Respiratory Management Technology | Particle counting and DNA uptake system and method for detection, assessment and further analysis of threats due to nebulized biological agents |
| CN101300845B (zh) * | 2005-09-06 | 2012-10-03 | 因弗拉吉斯公司 | 具有集成显示系统的威胁检测和监视设备 |
| JP5601746B2 (ja) * | 2006-03-16 | 2014-10-08 | 日本ソフトウェアマネジメント株式会社 | 同一の試料を用いた二段階核酸検査方法 |
| US20070292844A1 (en) * | 2006-03-22 | 2007-12-20 | Northrop Grumman Corporation | Enhanced biohazard detection system |
| US7343782B2 (en) * | 2006-04-10 | 2008-03-18 | Northrop Grumman Corporation | System and method for performing quantifiable release spore testing on bioaerosol detection technologies |
| US7858366B2 (en) * | 2006-08-24 | 2010-12-28 | Microfluidic Systems, Inc | Integrated airborne substance collection and detection system |
| JP2010510964A (ja) * | 2006-09-19 | 2010-04-08 | アシュラジェン インコーポレイテッド | 治療的介入の標的としての、ｍｉＲ−１５、ｍｉＲ−２６、ｍｉＲ−３１、ｍｉＲ−１４５、ｍｉＲ−１４７、ｍｉＲ−１８８、ｍｉＲ−２１５、ｍｉＲ−２１６、ｍｉＲ−３３１、ｍｍｕ−ｍｉＲ−２９２−３ｐによって調節される遺伝子および経路 |
| AU2007299828C1 (en) * | 2006-09-19 | 2014-07-17 | Interpace Diagnostics, Llc | MicroRNAs differentially expressed in pancreatic diseases and uses thereof |
| CA2671299A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Functions and targets of let-7 micro rnas |
| CN101622350A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为干预治疗靶标的miR-126调控基因和通路 |
| CA2671294A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US7851207B1 (en) * | 2007-02-07 | 2010-12-14 | The United States Of America As Represented By The Secretary Of The Army | Multiplex field device to detect and identify a variety of microbial agents simultaneously |
| US7543478B2 (en) * | 2007-04-12 | 2009-06-09 | Northrop Grumman Systems Corporation | Device and method for detecting hazardous material in mail |
| DE102007021387A1 (de) * | 2007-05-04 | 2008-11-06 | Eads Deutschland Gmbh | Detektionsvorrichtung zur Detektion von biologischen Mikropartikeln wie Bakterien, Viren, Sporen, Pollen oder biologische Toxine, sowie Detektionsverfahren |
| US8047053B2 (en) * | 2007-05-09 | 2011-11-01 | Icx Technologies, Inc. | Mail parcel screening using multiple detection technologies |
| US20090131354A1 (en) * | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| FR2917095B1 (fr) * | 2007-06-07 | 2009-07-17 | Biomerieux Sa | Dispositif de lyse de microorganismes presents dans un echantillon environnemental ou clinique et d'extraction des acides nucleiques desdits microorganismes aux fins d'analyse. |
| WO2008154333A2 (en) * | 2007-06-08 | 2008-12-18 | Asuragen, Inc. | Mir-34 regulated genes and pathways as targets for therapeutic intervention |
| US20090004662A1 (en) * | 2007-06-18 | 2009-01-01 | Applera Corporation | Method and compositions for nucleic acid amplification |
| WO2009036332A1 (en) | 2007-09-14 | 2009-03-19 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| WO2009052386A1 (en) * | 2007-10-18 | 2009-04-23 | Asuragen, Inc. | Micrornas differentially expressed in lung diseases and uses thereof |
| US7770476B2 (en) * | 2007-11-26 | 2010-08-10 | International Business Machines Corporation | Capturing air samples for forensic investigation |
| WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| WO2009086156A2 (en) * | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
| US20090263803A1 (en) * | 2008-02-08 | 2009-10-22 | Sylvie Beaudenon | Mirnas differentially expressed in lymph nodes from cancer patients |
| WO2009111643A2 (en) * | 2008-03-06 | 2009-09-11 | Asuragen, Inc. | Microrna markers for recurrence of colorectal cancer |
| WO2009154835A2 (en) * | 2008-03-26 | 2009-12-23 | Asuragen, Inc. | Compositions and methods related to mir-16 and therapy of prostate cancer |
| EP2285960B1 (en) | 2008-05-08 | 2015-07-08 | Asuragen, INC. | Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis |
| EP2304445B1 (en) | 2008-07-09 | 2020-06-10 | Micropoint Bioscience Inc | Analytical cartridge with fluid flow control |
| WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
| FR2939445B1 (fr) * | 2008-12-10 | 2013-05-03 | Biomerieux Sa | Systeme automatise de lyse de microorganismes presents dans un echantillon, d'extraction et de purification des acides nucleiques desdits microorganismes aux fins d'analyse. |
| FR2940151B1 (fr) * | 2008-12-23 | 2010-12-17 | Solystic | Machine pour trier des objets postaux grand format et des lettres |
| US8243274B2 (en) * | 2009-03-09 | 2012-08-14 | Flir Systems, Inc. | Portable diesel particulate monitor |
| WO2010115142A2 (en) * | 2009-04-03 | 2010-10-07 | Mesosystems Technology Inc. | Method and apparatus for capturing viable biological particles over an extended period of time |
| US20120297974A1 (en) * | 2010-01-27 | 2012-11-29 | Maxfor Technology Inc. | System for collecting polluted air, device for collecting polluted air and method thereof |
| US8720036B2 (en) | 2010-03-09 | 2014-05-13 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
| RU2488802C2 (ru) * | 2011-08-23 | 2013-07-27 | Федеральное государственное военное образовательное учреждение высшего профессионального образования "Военный авиационный инженерный университет" (г. Воронеж) Министерства обороны Российской Федерации | Устройство для автоматического отбора проб |
| WO2013032360A1 (ru) * | 2011-08-31 | 2013-03-07 | ГЕРМАН, Дмитрий Александрович | Способ и система обнаружения и определения места нахождения нежелательных веществ в контролируемых зонах и узел выхода воздушного коллектора такой системы |
| WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
| US9023640B2 (en) * | 2011-12-13 | 2015-05-05 | Fundamental Solutions Corporation | Device for rapid detection of infectious agents |
| CA2869717C (en) * | 2012-04-13 | 2022-09-06 | Becton, Dickinson And Company | Reflex testing of samples using residual materials from a prior test |
| FR2993281B1 (fr) | 2012-07-13 | 2014-07-18 | Biomerieux Sa | Systeme automatise de lyse de microorganismes presents dans un echantillon, d'extraction et de purification des acides nucleiques desdits microorganismes aux fins d'analyse |
| JP6480410B2 (ja) * | 2013-03-15 | 2019-03-13 | セフェィド | 複数チャンバの蓋装置 |
| EP3470527A1 (en) * | 2015-03-31 | 2019-04-17 | Fundamental Solutions Corporation | Chimeric fusion protein fcgammari-igm |
| EP3368314A4 (en) | 2015-10-30 | 2019-05-01 | Seurat Technologies, Inc. | MULTIFUNCTIONAL INGESTER SYSTEM FOR GENERATIVE MANUFACTURING |
| FR3043782B1 (fr) | 2015-11-13 | 2017-12-08 | Horiba Abx Sas | Dispositif d'agitation et de prelevement d'echantillons de liquides biologiques adapte pour trier |
| FR3043781B1 (fr) * | 2015-11-13 | 2017-12-08 | Horiba Abx Sas | Dispositif d'agitation et de prelevement d'echantillons de liquides biologiques |
| FR3043783B1 (fr) * | 2015-11-13 | 2017-12-08 | Horiba Abx Sas | Dispositif d'agitation et de prelevement d'echantillons de liquides biologiques adapte pour trier |
| AU2017362505B2 (en) | 2016-11-18 | 2023-02-02 | Cepheid | Sample processing module array handling system and methods |
| US12474242B2 (en) * | 2017-04-21 | 2025-11-18 | The Board Of Trustees Of The Leland Stanford Junior University | Exposome tracker for environmental health |
| RU2709460C9 (ru) * | 2018-12-28 | 2020-03-25 | Российская Федерация в лице Министерства здравоохранения | Способ выявления биопатогенов в воздухе |
| RU2694114C1 (ru) * | 2018-12-28 | 2019-07-09 | Российская Федерация, от имени которой выступает Министерство здравоохранения Российской Федерации | Автоматический анализатор биопатогенов в воздухе |
| US12054320B2 (en) | 2019-09-23 | 2024-08-06 | Cepheid | Multi-chambered lid apparatus with reagent port |
| RU199877U1 (ru) * | 2020-03-03 | 2020-09-24 | федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский горный университет" | Устройство для отбора и транспортировки проб атмосферного воздуха |
| US20210293817A1 (en) * | 2020-03-20 | 2021-09-23 | Morou Boukari | Method and device for detectioning and monitoring the presence, development and propagation of infectious agents, in particular bacteria and viruses |
| IT202000027381A1 (it) * | 2020-11-16 | 2022-05-16 | U Earth Biotech Ltd | Sistemi e metodi per il monitoraggio dell’aria |
| US12311304B2 (en) | 2020-11-24 | 2025-05-27 | Eagle Aerospace Ltd. | Device for decontaminating a region and verifying decontamination of the region |
| US12162074B2 (en) | 2020-11-25 | 2024-12-10 | Lawrence Livermore National Security, Llc | System and method for large-area pulsed laser melting of metallic powder in a laser powder bed fusion application |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1454602A (en) * | 1974-05-02 | 1976-11-03 | Jenkins A | Apparatus for checking the contents of closed containers |
| SU869455A1 (ru) * | 1977-02-14 | 1982-09-15 | Предприятие П/Я Г-4896 | Газовый хроматограф |
| US4213253A (en) * | 1978-06-12 | 1980-07-22 | Nida Corporation | Electronic teaching and testing device |
| DE3582758D1 (de) | 1984-07-17 | 1991-06-13 | British Aerospace | Verfahren und anordnung zur entdeckung von schmuggelsubstanz. |
| US4678752A (en) * | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
| SU1679311A1 (ru) * | 1988-11-03 | 1991-09-23 | Организация П/Я А-7574 | Устройство дл радиационной интроскопии |
| US4923491A (en) * | 1989-01-04 | 1990-05-08 | Research Triangle Institute | Centrifugal filter for separating aerosol particles from a gas stream |
| KR100236506B1 (ko) * | 1990-11-29 | 2000-01-15 | 퍼킨-엘머시터스인스트루먼츠 | 폴리머라제 연쇄 반응 수행 장치 |
| RU2064790C1 (ru) * | 1992-04-14 | 1996-08-10 | Петр Николаевич Бойцев | Устройство автоматического контроля и регулирования биофизических параметров биологического объекта |
| US5425263A (en) * | 1993-06-01 | 1995-06-20 | Barringer Research Limited | Method for inspecting an article for concealed substances |
| WO1996039625A1 (en) * | 1995-06-06 | 1996-12-12 | Beltronics Inc. | Automatic protein and/or dna analysis system and method |
| US5849208A (en) * | 1995-09-07 | 1998-12-15 | Microfab Technoologies, Inc. | Making apparatus for conducting biochemical analyses |
| EP0990142A4 (en) * | 1996-12-31 | 2000-09-27 | Genometrix Genomics Inc | MULTIPLEXED MOLECULAR ANALYSIS METHOD AND DEVICE |
| US5855652A (en) * | 1997-01-31 | 1999-01-05 | Topaz 2000, Inc. | Aerosol collector and concentrator |
| CA2273729A1 (en) * | 1998-07-14 | 2000-01-14 | Bayer Corporation | Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics |
| US5989824A (en) * | 1998-11-04 | 1999-11-23 | Mesosystems Technology, Inc. | Apparatus and method for lysing bacterial spores to facilitate their identification |
| US6887710B2 (en) * | 1998-11-13 | 2005-05-03 | Mesosystems Technology, Inc. | Robust system for screening mail for biological agents |
| US6337213B1 (en) * | 1998-12-21 | 2002-01-08 | The Regents Of The University Of California | Apparatus and method for collection and concentration of respirable particles into a small fluid volume |
| US6468330B1 (en) * | 1999-06-14 | 2002-10-22 | Innovatek, Inc. | Mini-cyclone biocollector and concentrator |
| DE10017802A1 (de) * | 2000-04-10 | 2001-10-11 | Bilatec Ges Zur Entwicklung Bi | Labor-Roboter mit Vielzweckgreifer |
| EP1136825A1 (de) * | 2000-03-13 | 2001-09-26 | Biopsytec S.A.R.L. | Vorrichtung zur automatisierten Ordnung, Erfassung und Einlagerung von Reaktionsbehältern |
| GB0024227D0 (en) * | 2000-10-04 | 2000-11-15 | Secr Defence | Air samplers |
| US6659945B2 (en) * | 2001-06-29 | 2003-12-09 | Depuy Orthopaedics, Inc. | Self retaining retractor ring |
| US7044911B2 (en) * | 2001-06-29 | 2006-05-16 | Philometron, Inc. | Gateway platform for biological monitoring and delivery of therapeutic compounds |
| US6610977B2 (en) * | 2001-10-01 | 2003-08-26 | Lockheed Martin Corporation | Security system for NBC-safe building |
| US6765490B2 (en) * | 2001-10-23 | 2004-07-20 | Steven W. Lopez | System and methods for detecting harmful agents within contents of mail |
| AU2002367479A1 (en) * | 2001-11-09 | 2003-10-20 | Lockheed Martin Corporation | A system for the detection of pathogens in the mail stream |
| WO2003046515A1 (en) * | 2001-11-29 | 2003-06-05 | Lockheed Martin Corporation | Apparatus for testing for particulate contaminants in depositories for mail-like articles |
| US7224825B2 (en) * | 2002-04-18 | 2007-05-29 | Lockheed Martin Corporation | Detecting and identifying hazardous substances contained in mail articles |
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| CA2482031A1 (en) | 2004-03-04 |
| RU2004128464A (ru) | 2005-08-10 |
| US20040063197A1 (en) | 2004-04-01 |
| EP1508024A1 (en) | 2005-02-23 |
| US20040063198A1 (en) | 2004-04-01 |
| WO2004018704A9 (en) | 2004-04-22 |
| AU2003239506A1 (en) | 2003-12-12 |
| RU2316748C2 (ru) | 2008-02-10 |
| WO2003100382A1 (en) | 2003-12-04 |
| RU2318197C2 (ru) | 2008-02-27 |
| AU2003285852A1 (en) | 2004-03-11 |
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| US7405073B2 (en) | 2008-07-29 |
| KR20050037991A (ko) | 2005-04-25 |
| EP1508025A2 (en) | 2005-02-23 |
| WO2004018704A3 (en) | 2004-06-10 |
| JP2005526977A (ja) | 2005-09-08 |
| KR20050084787A (ko) | 2005-08-29 |
| AU2003239506B2 (en) | 2007-08-02 |
| IL164224A0 (en) | 2005-12-18 |
| AU2003285852B2 (en) | 2006-12-14 |
| JP2005526522A (ja) | 2005-09-08 |
| RU2004128463A (ru) | 2005-07-10 |
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| EEER | Examination request | ||
| FZDE | Discontinued |