CA2481095C - A spacer for inertial removal of the non-respirable fraction of medicinal aerosols - Google Patents
A spacer for inertial removal of the non-respirable fraction of medicinal aerosols Download PDFInfo
- Publication number
- CA2481095C CA2481095C CA2481095A CA2481095A CA2481095C CA 2481095 C CA2481095 C CA 2481095C CA 2481095 A CA2481095 A CA 2481095A CA 2481095 A CA2481095 A CA 2481095A CA 2481095 C CA2481095 C CA 2481095C
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- spacer
- outlet
- inlet
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 125000006850 spacer group Chemical group 0.000 title claims abstract description 53
- 239000000443 aerosol Substances 0.000 title claims abstract description 44
- 239000002245 particle Substances 0.000 claims description 38
- 238000004891 communication Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 5
- 238000002663 nebulization Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 5
- 210000004072 lung Anatomy 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 241000124008 Mammalia Species 0.000 abstract description 2
- 238000000151 deposition Methods 0.000 description 7
- 230000008021 deposition Effects 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 229940112141 dry powder inhaler Drugs 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940071648 metered dose inhaler Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 241001135254 Bisgaard taxa Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37394502P | 2002-04-19 | 2002-04-19 | |
| US60/373,945 | 2002-04-19 | ||
| PCT/US2003/005205 WO2003089036A1 (en) | 2002-04-19 | 2003-02-20 | A spacer for inertial removal of the non-respirable fraction of medicinal aerosols |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2481095A1 CA2481095A1 (en) | 2003-10-30 |
| CA2481095C true CA2481095C (en) | 2013-02-19 |
Family
ID=29251105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2481095A Expired - Fee Related CA2481095C (en) | 2002-04-19 | 2003-02-20 | A spacer for inertial removal of the non-respirable fraction of medicinal aerosols |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6932082B2 (enExample) |
| EP (2) | EP2186536B1 (enExample) |
| JP (2) | JP4913325B2 (enExample) |
| AT (2) | ATE453422T1 (enExample) |
| AU (2) | AU2003215347A1 (enExample) |
| CA (1) | CA2481095C (enExample) |
| DE (1) | DE60330761D1 (enExample) |
| ES (1) | ES2382038T3 (enExample) |
| WO (1) | WO2003089036A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050121025A1 (en) * | 2003-12-04 | 2005-06-09 | Gamard Stephan C.F. | Portable gas operating inhaler |
| GB0427028D0 (en) * | 2004-12-09 | 2005-01-12 | Cambridge Consultants | Dry powder inhalers |
| FR2879465B1 (fr) * | 2004-12-21 | 2008-02-15 | Diffusion Tech Francaise Sarl | Dispositif de transfert d'aerosols pour generateurs d'aerosols medicaux ou systemes de generation d'aerosols medicaux |
| US8763605B2 (en) | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
| EP1998832B1 (en) * | 2006-03-24 | 2014-10-22 | 3M Innovative Properties Company | Method for assessing the suitability of metered dose inhaler actuators |
| GB0611659D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
| GB0611656D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
| CA2691191A1 (en) * | 2007-06-28 | 2008-12-31 | Per Gerde | Exposure system |
| US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
| EP3453418A1 (en) * | 2007-07-06 | 2019-03-13 | Manta Devices, LLC | Delivery device and related methods |
| WO2009079078A1 (en) | 2007-12-14 | 2009-06-25 | Labogroup S.A.S. | Delivering aerosolizable food products |
| US8176766B1 (en) * | 2008-03-27 | 2012-05-15 | Alcotek, Inc. | Liquid and solid trapping mouthpiece |
| SI2285439T1 (sl) | 2008-04-04 | 2014-05-30 | Nektar Therapeutics | Naprava za aerosolizacijo |
| WO2010083042A1 (en) * | 2009-01-15 | 2010-07-22 | Manta Devices, Llc | Delivery device |
| WO2011116293A2 (en) | 2010-03-19 | 2011-09-22 | Manta Devices, Llc | Delivery device and related methods |
| US11103659B2 (en) | 2011-07-06 | 2021-08-31 | Manta Devices, Llc | Delivery device and related methods |
| US9649454B2 (en) | 2012-05-03 | 2017-05-16 | Manta Devices, Llc | Delivery device and related methods |
| EP2900133B1 (en) * | 2012-09-25 | 2019-02-27 | Inhalation Sciences Sweden AB | Exposure method and device for aerosol and model material interaction |
| EP3345643B1 (en) | 2013-03-15 | 2021-01-06 | Chris V. Ciancone | Inhaler spacer and storage apparatus |
| WO2015168572A2 (en) | 2014-05-02 | 2015-11-05 | Manta Devices, Llc | Delivery device and related methods |
| WO2016044775A1 (en) * | 2014-09-19 | 2016-03-24 | Aerovu Technologies, Inc. | Spacer device with flow rate spirometer cross reference to related application (s) |
| WO2017192782A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment |
| EP4591994A3 (en) | 2016-05-03 | 2025-10-01 | Pneuma Respiratory, Inc. | A droplet delivery device for generating and delivering droplets to the pulmonary system |
| US20210236745A1 (en) | 2016-05-03 | 2021-08-05 | Pneuma Respiratory, Inc. | Droplet delivery device for delivery of fluids to the pulmonary system and methods of use |
| US11285284B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency |
| US11285274B2 (en) | 2016-05-03 | 2022-03-29 | Pneuma Respiratory, Inc. | Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device |
| CN110799231B (zh) | 2017-05-19 | 2022-08-02 | 精呼吸股份有限公司 | 干粉输送装置及其使用方法 |
| CA3077475A1 (en) | 2017-10-04 | 2019-04-11 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device and methods of use |
| EP3697481B1 (en) | 2017-10-17 | 2024-05-22 | Pneuma Respiratory, Inc. | Nasal drug delivery apparatus and methods of use |
| CN111479604B (zh) | 2017-11-08 | 2022-12-30 | 精呼吸股份有限公司 | 具有小体积安瓿的电动呼吸致动直列液滴输送装置及使用方法 |
| TWI662264B (zh) * | 2018-04-20 | 2019-06-11 | 國立臺灣大學 | 分徑採樣器 |
| WO2019236662A1 (en) | 2018-06-05 | 2019-12-12 | Teleflex Medical Incorporated | Valved spacer for inhalation device |
| WO2022013088A1 (en) * | 2020-07-14 | 2022-01-20 | Stamford Devices Limited | A vaccine administration apparatus and method |
| JP6958950B1 (ja) * | 2020-11-27 | 2021-11-02 | ニップファーマ株式会社 | 吸入補助器 |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| EP4659870A2 (en) | 2021-06-22 | 2025-12-10 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
| JP1700983S (enExample) * | 2021-06-23 | 2021-11-29 | ||
| KR20250038748A (ko) | 2022-07-18 | 2025-03-19 | 뉴마 레스퍼러토리 인코포레이티드 | 작은 스텝 크기 및 고해상도 에어로졸 생성 시스템 및 방법 |
| KR102842879B1 (ko) * | 2022-10-31 | 2025-08-07 | 주식회사 케이티앤지 | 인헤일러 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US506368A (en) * | 1893-10-10 | Inhaling apparatus | ||
| US1263079A (en) * | 1915-10-04 | 1918-04-16 | Leon S Leon | Inhaling apparatus. |
| US1853242A (en) * | 1930-09-24 | 1932-04-12 | Howard A Sliter | Means for nebulizing liquids |
| US2381558A (en) * | 1943-07-15 | 1945-08-07 | Gerard B Robinson | Plastic atomizer |
| US3038532A (en) * | 1960-01-12 | 1962-06-12 | Bernard J Eisenkraft | Spray process equipment |
| US3362405A (en) * | 1964-04-06 | 1968-01-09 | Hamilton O. Hazel | Method and apparatus for admixing gas with solid particles |
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US4228795A (en) * | 1977-03-08 | 1980-10-21 | Babington Robert S | Apparatus for producing finely divided liquid spray |
| IT1116047B (it) | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
| FI89458C (fi) | 1986-11-06 | 1993-10-11 | Leiras Oy | Inhaleringsanordning |
| CA2092614C (en) | 1990-09-12 | 1996-04-09 | Hans Bisgaard | An inhaling device |
| DE59107894D1 (de) * | 1991-03-21 | 1996-07-11 | Ritzau Pari Werk Gmbh Paul | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
| CA2112674C (en) | 1991-07-02 | 2005-10-04 | John S. Patton | Method and device for delivering aerosolized medicaments |
| US5170782A (en) | 1991-09-12 | 1992-12-15 | Devilbiss Health Care, Inc. | Medicament nebulizer with improved aerosol chamber |
| DE4211475A1 (de) | 1991-12-14 | 1993-06-17 | Asta Medica Ag | Pulverinhalator |
| US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
| US5186166A (en) * | 1992-03-04 | 1993-02-16 | Riggs John H | Powder nebulizer apparatus and method of nebulization |
| DE4208880A1 (de) | 1992-03-19 | 1993-09-23 | Boehringer Ingelheim Kg | Separator fuer pulverinhalatoren |
| JPH0678997A (ja) * | 1992-09-02 | 1994-03-22 | Izumi Kenkyusho:Kk | 肺胞到達液粒子発生方法及びそれを利用した治療器 |
| DE59409856D1 (de) * | 1994-05-19 | 2001-10-11 | Pari Gmbh | Vorrichtung zur Trocknung und Pufferung von Aerosolen |
| DE19523516C1 (de) | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
| US6042628A (en) * | 1996-11-12 | 2000-03-28 | Toyo Gijutsu Kogyo Co., Ltd. | Cyclone type dust collector |
| US5685291A (en) * | 1996-11-15 | 1997-11-11 | Marsh; Jean Ann | Nebulizer adapter system for premature babies |
| GB9626263D0 (en) | 1996-12-18 | 1997-02-05 | Innovata Biomed Ltd | Powder inhaler |
| US6073629A (en) | 1997-09-25 | 2000-06-13 | Norton Healthcare Ltd. | Inhaler spacer |
| KR100312018B1 (ko) | 1999-03-10 | 2001-11-03 | 김효근 | 공기에 포함된 분진제거용 이중 원심분리기 |
| GB2353222B (en) * | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| EP1129705A1 (en) | 2000-02-17 | 2001-09-05 | Rijksuniversiteit te Groningen | Powder formulation for inhalation |
| GB2364919A (en) | 2000-07-21 | 2002-02-13 | Cambridge Consultants | Inhalers |
-
2003
- 2003-02-20 AU AU2003215347A patent/AU2003215347A1/en not_active Abandoned
- 2003-02-20 EP EP09178276A patent/EP2186536B1/en not_active Expired - Lifetime
- 2003-02-20 CA CA2481095A patent/CA2481095C/en not_active Expired - Fee Related
- 2003-02-20 US US10/370,973 patent/US6932082B2/en not_active Expired - Lifetime
- 2003-02-20 AT AT03711168T patent/ATE453422T1/de not_active IP Right Cessation
- 2003-02-20 ES ES09178276T patent/ES2382038T3/es not_active Expired - Lifetime
- 2003-02-20 JP JP2003585787A patent/JP4913325B2/ja not_active Expired - Fee Related
- 2003-02-20 AT AT09178276T patent/ATE551087T1/de active
- 2003-02-20 EP EP03711168A patent/EP1496966B1/en not_active Expired - Lifetime
- 2003-02-20 WO PCT/US2003/005205 patent/WO2003089036A1/en not_active Ceased
- 2003-02-20 DE DE60330761T patent/DE60330761D1/de not_active Expired - Lifetime
-
2009
- 2009-06-03 AU AU2009202201A patent/AU2009202201A1/en not_active Abandoned
-
2010
- 2010-02-22 JP JP2010036090A patent/JP5215339B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2186536A1 (en) | 2010-05-19 |
| JP5215339B2 (ja) | 2013-06-19 |
| JP4913325B2 (ja) | 2012-04-11 |
| EP2186536B1 (en) | 2012-03-28 |
| US6932082B2 (en) | 2005-08-23 |
| EP1496966A1 (en) | 2005-01-19 |
| US20030196654A1 (en) | 2003-10-23 |
| EP1496966B1 (en) | 2009-12-30 |
| WO2003089036A1 (en) | 2003-10-30 |
| JP2010115526A (ja) | 2010-05-27 |
| CA2481095A1 (en) | 2003-10-30 |
| AU2003215347A1 (en) | 2003-11-03 |
| DE60330761D1 (de) | 2010-02-11 |
| JP2005523083A (ja) | 2005-08-04 |
| ES2382038T3 (es) | 2012-06-04 |
| ATE453422T1 (de) | 2010-01-15 |
| AU2009202201A1 (en) | 2009-06-25 |
| ATE551087T1 (de) | 2012-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190220 |