CA2476454A1 - Utilisation d'inhibiteurs de l'echangeur chlorure-bicarbonate sodium-dependant pour traiter des affections thrombotiques et inflammatoires - Google Patents
Utilisation d'inhibiteurs de l'echangeur chlorure-bicarbonate sodium-dependant pour traiter des affections thrombotiques et inflammatoires Download PDFInfo
- Publication number
- CA2476454A1 CA2476454A1 CA002476454A CA2476454A CA2476454A1 CA 2476454 A1 CA2476454 A1 CA 2476454A1 CA 002476454 A CA002476454 A CA 002476454A CA 2476454 A CA2476454 A CA 2476454A CA 2476454 A1 CA2476454 A1 CA 2476454A1
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- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- independently
- phenyl
- Prior art date
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- Abandoned
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- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 description 1
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
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- 230000001629 suppression Effects 0.000 description 1
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- 238000003786 synthesis reaction Methods 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
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- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
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- 125000001425 triazolyl group Chemical group 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 235000019168 vitamin K Nutrition 0.000 description 1
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Immunology (AREA)
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- Cardiology (AREA)
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- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Paper (AREA)
Abstract
L'invention concerne l'utilisation d'inhibiteurs de l'échangeur chlorure-bicarbonate pour traiter des affections thrombotiques et inflammatoires. Des inhibiteurs de l'échangeur chlorure-bicarbonate sodium-dépendant présentent un effet inhibiteur sur la sécrétion du facteur de von Willebrand. Ces inhibiteurs peuvent de ce fait s'utiliser pour traiter des affections thrombotiques et inflammatoires.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10206354A DE10206354A1 (de) | 2002-02-14 | 2002-02-14 | Verwendung von Inhibitoren des Natrium-abhängigen Chlorid-Bicarbonat-Austauschers zur Behandlung von thrombotischen und inflammatorischer Erkrankungen |
DE10206354.0 | 2002-02-14 | ||
PCT/EP2003/001100 WO2003068224A2 (fr) | 2002-02-14 | 2003-02-05 | Utilisation d'inhibiteurs de l'echangeur chlorure-bicarbonate sodium-dependant pour traiter des affections thrombotiques et inflammatoires |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2476454A1 true CA2476454A1 (fr) | 2003-08-21 |
Family
ID=27634996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002476454A Abandoned CA2476454A1 (fr) | 2002-02-14 | 2003-02-05 | Utilisation d'inhibiteurs de l'echangeur chlorure-bicarbonate sodium-dependant pour traiter des affections thrombotiques et inflammatoires |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1476154A2 (fr) |
JP (1) | JP2005525338A (fr) |
AR (1) | AR038837A1 (fr) |
AU (1) | AU2003208792A1 (fr) |
BR (1) | BR0307637A (fr) |
CA (1) | CA2476454A1 (fr) |
DE (1) | DE10206354A1 (fr) |
MX (1) | MXPA04007007A (fr) |
TW (1) | TW200306808A (fr) |
WO (1) | WO2003068224A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112013011188B1 (pt) | 2010-11-05 | 2022-01-04 | Senomyx, Inc | Método não-médico para modular canal potencial de receptor transiente de melastina 8 (trpm8), método não-médico para modular a sensação de resfriamento de uma composição, método não-médico para induzir uma sensação de resfriamento em um humano ou animal e composto |
EP3356356B1 (fr) | 2015-10-01 | 2021-05-26 | Firmenich Incorporated | Composés utiles en tant que modulateurs de trpm8 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19741635A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19804251A1 (de) * | 1998-02-04 | 1999-08-05 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
2002
- 2002-02-14 DE DE10206354A patent/DE10206354A1/de not_active Withdrawn
-
2003
- 2003-02-05 JP JP2003567406A patent/JP2005525338A/ja not_active Abandoned
- 2003-02-05 CA CA002476454A patent/CA2476454A1/fr not_active Abandoned
- 2003-02-05 AU AU2003208792A patent/AU2003208792A1/en not_active Abandoned
- 2003-02-05 EP EP03706428A patent/EP1476154A2/fr not_active Withdrawn
- 2003-02-05 MX MXPA04007007A patent/MXPA04007007A/es not_active Application Discontinuation
- 2003-02-05 WO PCT/EP2003/001100 patent/WO2003068224A2/fr not_active Application Discontinuation
- 2003-02-05 BR BR0307637-7A patent/BR0307637A/pt not_active IP Right Cessation
- 2003-02-12 TW TW092102812A patent/TW200306808A/zh unknown
- 2003-02-12 AR ARP030100449A patent/AR038837A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2003208792A1 (en) | 2003-09-04 |
BR0307637A (pt) | 2005-01-04 |
MXPA04007007A (es) | 2004-10-11 |
EP1476154A2 (fr) | 2004-11-17 |
WO2003068224A3 (fr) | 2003-12-24 |
DE10206354A1 (de) | 2003-08-28 |
AR038837A1 (es) | 2005-01-26 |
WO2003068224A2 (fr) | 2003-08-21 |
JP2005525338A (ja) | 2005-08-25 |
TW200306808A (en) | 2003-12-01 |
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