CA2475234A1 - Flow-independent parameter estimation based on tidal breathing exhalation profiles - Google Patents
Flow-independent parameter estimation based on tidal breathing exhalation profiles Download PDFInfo
- Publication number
- CA2475234A1 CA2475234A1 CA002475234A CA2475234A CA2475234A1 CA 2475234 A1 CA2475234 A1 CA 2475234A1 CA 002475234 A CA002475234 A CA 002475234A CA 2475234 A CA2475234 A CA 2475234A CA 2475234 A1 CA2475234 A1 CA 2475234A1
- Authority
- CA
- Canada
- Prior art keywords
- flow
- model
- data
- compartment
- tidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000029058 respiratory gaseous exchange Effects 0.000 title claims abstract description 78
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims abstract description 222
- 238000000034 method Methods 0.000 claims abstract description 49
- 210000004072 lung Anatomy 0.000 claims abstract description 25
- 230000000694 effects Effects 0.000 claims description 13
- 238000012544 monitoring process Methods 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 8
- 230000002829 reductive effect Effects 0.000 claims description 7
- 230000000737 periodic effect Effects 0.000 claims description 3
- 210000002345 respiratory system Anatomy 0.000 claims 3
- 208000023504 respiratory system disease Diseases 0.000 claims 3
- 230000036962 time dependent Effects 0.000 claims 2
- 238000012512 characterization method Methods 0.000 abstract description 6
- 208000019693 Lung disease Diseases 0.000 abstract description 2
- 230000002757 inflammatory effect Effects 0.000 abstract description 2
- 230000035945 sensitivity Effects 0.000 description 21
- 230000009897 systematic effect Effects 0.000 description 15
- 230000004907 flux Effects 0.000 description 13
- 239000007789 gas Substances 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 12
- 230000035565 breathing frequency Effects 0.000 description 11
- 230000008859 change Effects 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 9
- 230000007423 decrease Effects 0.000 description 6
- 238000012886 linear function Methods 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 208000027866 inflammatory disease Diseases 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- ZPEZUAAEBBHXBT-WCCKRBBISA-N (2s)-2-amino-3-methylbutanoic acid;2-amino-3-methylbutanoic acid Chemical compound CC(C)C(N)C(O)=O.CC(C)[C@H](N)C(O)=O ZPEZUAAEBBHXBT-WCCKRBBISA-N 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 230000001010 compromised effect Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000004199 lung function Effects 0.000 description 3
- 210000004879 pulmonary tissue Anatomy 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 238000013076 uncertainty analysis Methods 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 101150117824 Calr gene Proteins 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000013213 extrapolation Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000013178 mathematical model Methods 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010001889 Alveolitis Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 206010006322 Breath holding Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 241000917105 Forda Species 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 238000007476 Maximum Likelihood Methods 0.000 description 1
- 206010059411 Prolonged expiration Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000003123 bronchiole Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003434 inspiratory effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000009428 plumbing Methods 0.000 description 1
- 230000009290 primary effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000756 time-weighted average Toxicity 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35478102P | 2002-02-05 | 2002-02-05 | |
| US60/354,781 | 2002-02-05 | ||
| US38017502P | 2002-05-13 | 2002-05-13 | |
| US60/380,175 | 2002-05-13 | ||
| PCT/US2003/003472 WO2003067216A2 (en) | 2002-02-05 | 2003-02-05 | Flow-independent parameter estimation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2475234A1 true CA2475234A1 (en) | 2003-08-14 |
Family
ID=27737473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002475234A Abandoned CA2475234A1 (en) | 2002-02-05 | 2003-02-05 | Flow-independent parameter estimation based on tidal breathing exhalation profiles |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7156813B2 (https=) |
| EP (1) | EP1478266A4 (https=) |
| JP (1) | JP2005516704A (https=) |
| CN (1) | CN100393273C (https=) |
| AU (1) | AU2003219711A1 (https=) |
| CA (1) | CA2475234A1 (https=) |
| WO (1) | WO2003067216A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120372931A (zh) * | 2025-04-11 | 2025-07-25 | 江苏省水文地质工程地质勘察院 | 基于海上抽水试验潮汐影响的渗透系数优化方法及系统 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070282214A1 (en) * | 2006-05-16 | 2007-12-06 | The Regents Of The University Of California | Technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model |
| US7460959B2 (en) * | 2006-06-02 | 2008-12-02 | Nellcor Puritan Bennett Llc | System and method for estimating oxygen concentration in a mixed gas experiencing pressure fluctuations |
| US8166971B2 (en) * | 2007-03-15 | 2012-05-01 | Ric Investments, Llc | End-tidal gas estimation system and method |
| US8585412B2 (en) * | 2008-09-30 | 2013-11-19 | Covidien Lp | Configurable respiratory muscle pressure generator |
| CN102458245B (zh) * | 2009-04-20 | 2015-05-27 | 瑞思迈有限公司 | 使用血氧饱和度信号辨别潮式呼吸模式 |
| US20120123288A1 (en) * | 2009-07-30 | 2012-05-17 | Koninklijke Philips Electronics N.V. | Method and apparatus of determining exhaled nitric oxide |
| EP2490589B1 (en) | 2009-10-22 | 2017-07-26 | Koninklijke Philips N.V. | Method and apparatus for measuring the concentration of a gas in exhaled air |
| GB0919269D0 (en) | 2009-11-03 | 2009-12-16 | Univ Manchester | Lung function analysis method and apparatus |
| WO2011055286A1 (en) * | 2009-11-03 | 2011-05-12 | Koninklijke Philips Electronics N.V. | Apparatus for measuring a level of a specific gas in exhaled breath |
| US9763600B2 (en) | 2010-02-17 | 2017-09-19 | Koninklijke Philips N.V. | Nitric oxide measurement method and apparatus |
| TWI446129B (zh) * | 2012-02-15 | 2014-07-21 | Nat Applied Res Laboratories | 水位預報即時校正的方法 |
| CN107468256A (zh) | 2012-11-27 | 2017-12-15 | 纽玛凯尔有限公司 | 呼吸数据的分析 |
| US10307080B2 (en) | 2014-03-07 | 2019-06-04 | Spirosure, Inc. | Respiratory monitor |
| CN104407026A (zh) * | 2014-11-28 | 2015-03-11 | 无锡市尚沃医疗电子股份有限公司 | 一口气多参数呼气一氧化氮测量方法和装置 |
| CN104391087B (zh) * | 2014-12-08 | 2016-04-13 | 无锡市尚沃医疗电子股份有限公司 | 一种潮气呼气测定呼出气一氧化氮浓度方法及装置 |
| CN105388256B (zh) * | 2015-12-04 | 2017-07-07 | 无锡市尚沃医疗电子股份有限公司 | 呼出气中呼吸与循环系统气体分子浓度的测量方法 |
| US20170329927A1 (en) * | 2016-05-11 | 2017-11-16 | InFluidS LLC | System and method for analyzing airway-pulmonary response using computational fluid dynamics to diagnose and monitoring potential health anomalies |
| EP3506826B1 (en) * | 2016-09-01 | 2025-08-13 | Oxford University Innovation Limited | Method and apparatus for quantifying lung function |
| US11300552B2 (en) | 2017-03-01 | 2022-04-12 | Caire Diagnostics Inc. | Nitric oxide detection device with reducing gas |
| CN113808748B (zh) * | 2021-07-19 | 2023-11-28 | 浙江大学 | 一种肺腺泡血气交换功能的建模仿真方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267845A (en) * | 1978-10-05 | 1981-05-19 | Robertson Jr Charles H | Method and apparatus for measuring pulmonary ventilation |
| JP3248533B2 (ja) * | 1993-07-06 | 2002-01-21 | アエロクライン・アクチボラゲット | 呼気中のｎｏレベルの測定に使用されるシステムおよび異常ｎｏレベルに関連する疾患の診断方法 |
| US6033368A (en) * | 1996-03-28 | 2000-03-07 | Nitromed, Inc. | Condensate colorimetric nitrogen oxide analyzer |
| US6010459A (en) | 1996-04-09 | 2000-01-04 | Silkoff; Philip E. | Method and apparatus for the measurement of components of exhaled breath in humans |
| SE9701150D0 (sv) * | 1997-03-27 | 1997-03-27 | Nitrograf Ab | Anordning för att utvärdera NO-halten i en utandad luftström |
| ES2310511T3 (es) * | 1999-02-03 | 2009-01-16 | Mermaid Care A/S | Estimador automatico de parametros pulmonares. |
| EP1280449A4 (en) * | 2000-04-29 | 2009-04-08 | Univ California | DEVICE AND METHOD FOR ESTIMATING LUSS INDEPENDENT PARAMETERS THAT CHARACTERIZE THE RELEVANT CHARACTERISTICS OF NITROGEN OXIDE PRODUCTION AND STAIN OXYDE EXCHANGE IN THE HUMAN LUNG |
| FI110839B (fi) * | 2001-05-11 | 2003-04-15 | Lauri Lehtimaeki | Menetelmä ja mittauslaitteisto uloshengitysilman typpioksidipitoisuuden mittaamiseksi |
-
2003
- 2003-02-05 US US10/358,802 patent/US7156813B2/en not_active Expired - Fee Related
- 2003-02-05 WO PCT/US2003/003472 patent/WO2003067216A2/en not_active Ceased
- 2003-02-05 CN CNB038065932A patent/CN100393273C/zh not_active Expired - Fee Related
- 2003-02-05 EP EP03715979A patent/EP1478266A4/en not_active Withdrawn
- 2003-02-05 AU AU2003219711A patent/AU2003219711A1/en not_active Abandoned
- 2003-02-05 CA CA002475234A patent/CA2475234A1/en not_active Abandoned
- 2003-02-05 JP JP2003566518A patent/JP2005516704A/ja active Pending
-
2006
- 2006-11-14 US US11/599,684 patent/US7678062B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120372931A (zh) * | 2025-04-11 | 2025-07-25 | 江苏省水文地质工程地质勘察院 | 基于海上抽水试验潮汐影响的渗透系数优化方法及系统 |
| CN120372931B (zh) * | 2025-04-11 | 2025-09-26 | 江苏省水文地质工程地质勘察院 | 基于海上抽水试验潮汐影响的渗透系数优化方法及系统 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003219711A1 (en) | 2003-09-02 |
| US20070167854A1 (en) | 2007-07-19 |
| CN1642470A (zh) | 2005-07-20 |
| EP1478266A4 (en) | 2007-03-14 |
| US7156813B2 (en) | 2007-01-02 |
| HK1079076A1 (zh) | 2006-03-31 |
| AU2003219711A8 (en) | 2003-09-02 |
| US20030229290A1 (en) | 2003-12-11 |
| JP2005516704A (ja) | 2005-06-09 |
| CN100393273C (zh) | 2008-06-11 |
| WO2003067216A3 (en) | 2003-12-31 |
| WO2003067216A2 (en) | 2003-08-14 |
| EP1478266A2 (en) | 2004-11-24 |
| US7678062B2 (en) | 2010-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7678062B2 (en) | Flow-independent parameter estimation based on tidal breathing exhalation profiles | |
| EP2536333B1 (en) | Nitric oxide measurement method and apparatus | |
| US6866637B2 (en) | Apparatus and method for the estimation of flow -independent parameters which characterize the relevant features of nitric oxide production and exchange in the human lungs | |
| Hedenström et al. | Reference values for lung function tests in men: regression equations with smoking variables | |
| US7427269B2 (en) | Accurate method to characterize airway nitric oxide using different breath-hold times including axial diffusion of nitric oxide using heliox and breath hold | |
| EP2124744B1 (en) | End-tidal gas estimation system and method | |
| JP2005516704A5 (https=) | ||
| EP1030593B1 (en) | Method and apparatus for determining a pulmonary function parameter for gas exchange | |
| EP1397072B1 (en) | Method and apparatus for measuring functional residual capacity (frc) and cardiac output (co) | |
| US20090118633A1 (en) | End-Tidal Gas Estimation System and Method | |
| CN102469954A (zh) | 确定呼出一氧化氮的方法和设备 | |
| EP1632178A1 (en) | Method for non-cooperative lung function diagnosis using ultrasound | |
| CA3072580A1 (en) | A method for the early identification of exacerbations of chronic obstructive pulmonary disease | |
| US20060004297A1 (en) | Lung model-based cardiopulmonary performance determination | |
| US7993278B2 (en) | Method and system for non-invasively measuring pulmonary function | |
| Eichler et al. | Automated evaluation of functional residual capacity by oxygen washout | |
| EP4622546A1 (en) | Method and apparatus for determining arterial co2 concentration | |
| Desjardin et al. | Assessment of concordance between diffusion of carbon monoxide through the lung using the 10 s breath-hold method, and the simultaneous NO/CO technique, in healthy participants | |
| HK1079076B (en) | Flow-independent parameter estimation based on tidal breathing exhalation profiles | |
| EP1603447A1 (en) | A simple approach to precisely calculate o2 consumption, and anesthetic absorption during low flow anesthesia | |
| Luijendijk et al. | The ratio of the alveolar ventilations of SF6 and He in patients with lung emphysema and in healthy subjects | |
| Sylvester et al. | Respiratory measurement | |
| Kalicka et al. | The modelling of spirometry-The application for diagnostic purposes | |
| WO2006047212A1 (en) | Method and apparatus for effective lung volume estimation | |
| Budd et al. | Measuring gas exchange and gas mixing in children |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130205 |