CA2474446A1 - A method for the diagnosis of lymphoproliferative diseases - Google Patents
A method for the diagnosis of lymphoproliferative diseases Download PDFInfo
- Publication number
- CA2474446A1 CA2474446A1 CA 2474446 CA2474446A CA2474446A1 CA 2474446 A1 CA2474446 A1 CA 2474446A1 CA 2474446 CA2474446 CA 2474446 CA 2474446 A CA2474446 A CA 2474446A CA 2474446 A1 CA2474446 A1 CA 2474446A1
- Authority
- CA
- Canada
- Prior art keywords
- chromosome
- translocation
- gene
- ctcl
- nav3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 53
- 238000003745 diagnosis Methods 0.000 title claims abstract description 23
- 208000030289 Lymphoproliferative disease Diseases 0.000 title abstract description 35
- 210000000349 chromosome Anatomy 0.000 claims abstract description 187
- 230000005945 translocation Effects 0.000 claims abstract description 111
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 74
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims abstract description 65
- 230000002759 chromosomal effect Effects 0.000 claims abstract description 60
- 239000012634 fragment Substances 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims abstract description 28
- 101710145274 Neuron navigator 3 Proteins 0.000 claims abstract description 26
- 238000001514 detection method Methods 0.000 claims abstract description 20
- 208000028561 Primary cutaneous T-cell lymphoma Diseases 0.000 claims abstract description 19
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 18
- 238000011161 development Methods 0.000 claims abstract description 11
- 239000000523 sample Substances 0.000 claims description 44
- 201000005962 mycosis fungoides Diseases 0.000 claims description 33
- 102100030464 Neuron navigator 3 Human genes 0.000 claims description 31
- 201000010099 disease Diseases 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 238000012217 deletion Methods 0.000 claims description 24
- 230000037430 deletion Effects 0.000 claims description 24
- 208000009359 Sezary Syndrome Diseases 0.000 claims description 22
- 208000021388 Sezary disease Diseases 0.000 claims description 22
- 101100348015 Homo sapiens NAV3 gene Proteins 0.000 claims description 21
- 101150026704 NAV3 gene Proteins 0.000 claims description 21
- 230000007547 defect Effects 0.000 claims description 21
- 238000004458 analytical method Methods 0.000 claims description 20
- 102000004169 proteins and genes Human genes 0.000 claims description 18
- 230000006870 function Effects 0.000 claims description 17
- 239000012472 biological sample Substances 0.000 claims description 13
- 238000009396 hybridization Methods 0.000 claims description 13
- 238000011065 in-situ storage Methods 0.000 claims description 9
- 230000009466 transformation Effects 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 230000004075 alteration Effects 0.000 claims description 5
- 238000010422 painting Methods 0.000 claims description 5
- 239000003298 DNA probe Substances 0.000 claims description 3
- 238000009007 Diagnostic Kit Methods 0.000 claims description 3
- 230000003595 spectral effect Effects 0.000 claims description 3
- 238000001228 spectrum Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 239000000872 buffer Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 238000011002 quantification Methods 0.000 claims description 2
- 238000012800 visualization Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims 4
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 230000018109 developmental process Effects 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 3
- 239000000032 diagnostic agent Substances 0.000 abstract description 2
- 229940039227 diagnostic agent Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 229940124597 therapeutic agent Drugs 0.000 abstract description 2
- 208000024191 minimally invasive lung adenocarcinoma Diseases 0.000 description 63
- 210000002230 centromere Anatomy 0.000 description 22
- 230000001594 aberrant effect Effects 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 19
- 206010028980 Neoplasm Diseases 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 12
- 241000282414 Homo sapiens Species 0.000 description 10
- 108020004414 DNA Proteins 0.000 description 9
- 230000003211 malignant effect Effects 0.000 description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- 101000582005 Homo sapiens Neuron navigator 3 Proteins 0.000 description 8
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 230000002559 cytogenic effect Effects 0.000 description 6
- 230000014509 gene expression Effects 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 4
- 229960002685 biotin Drugs 0.000 description 4
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011616 biotin Substances 0.000 description 4
- 239000003086 colorant Substances 0.000 description 4
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 4
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 4
- 238000013399 early diagnosis Methods 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 230000000306 recurrent effect Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 3
- 208000031404 Chromosome Aberrations Diseases 0.000 description 3
- 208000037088 Chromosome Breakage Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000034951 Genetic Translocation Diseases 0.000 description 3
- 241000764238 Isis Species 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 3
- 108091008874 T cell receptors Proteins 0.000 description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 3
- 238000004590 computer program Methods 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
- 230000036210 malignancy Effects 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 230000031864 metaphase Effects 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 description 2
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 108700024394 Exon Proteins 0.000 description 2
- 101710176246 High mobility group protein Proteins 0.000 description 2
- WGZDBVOTUVNQFP-UHFFFAOYSA-N N-(1-phthalazinylamino)carbamic acid ethyl ester Chemical compound C1=CC=C2C(NNC(=O)OCC)=NN=CC2=C1 WGZDBVOTUVNQFP-UHFFFAOYSA-N 0.000 description 2
- 241001045988 Neogene Species 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 239000000074 antisense oligonucleotide Substances 0.000 description 2
- 238000012230 antisense oligonucleotides Methods 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 231100000005 chromosome aberration Toxicity 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
- 238000012224 gene deletion Methods 0.000 description 2
- 210000003917 human chromosome Anatomy 0.000 description 2
- 238000003364 immunohistochemistry Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 101150091879 neo gene Proteins 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 229930002330 retinoic acid Natural products 0.000 description 2
- 238000003757 reverse transcription PCR Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 230000004565 tumor cell growth Effects 0.000 description 2
- 206010000830 Acute leukaemia Diseases 0.000 description 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
- 241000244203 Caenorhabditis elegans Species 0.000 description 1
- 101100316120 Caenorhabditis elegans unc-53 gene Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 102000049982 HMGA2 Human genes 0.000 description 1
- 108700039143 HMGA2 Proteins 0.000 description 1
- 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 description 1
- 102100028999 High mobility group protein HMGI-C Human genes 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 description 1
- 101000986379 Homo sapiens High mobility group protein HMGI-C Proteins 0.000 description 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 102000002151 Microfilament Proteins Human genes 0.000 description 1
- 108010040897 Microfilament Proteins Proteins 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 101150114311 PAWR gene Proteins 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 108010047620 Phytohemagglutinins Proteins 0.000 description 1
- 229920000037 Polyproline Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 208000024530 Primary cutaneous B-cell lymphoma Diseases 0.000 description 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 108700025695 Suppressor Genes Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 108700025690 abl Genes Proteins 0.000 description 1
- ZCHPKWUIAASXPV-UHFFFAOYSA-N acetic acid;methanol Chemical compound OC.CC(O)=O ZCHPKWUIAASXPV-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000000701 chemical imaging Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 201000003444 follicular lymphoma Diseases 0.000 description 1
- 201000004528 gastrointestinal lymphoma Diseases 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 238000012333 histopathological diagnosis Methods 0.000 description 1
- 238000007489 histopathology method Methods 0.000 description 1
- 230000002895 hyperchromatic effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 201000003445 large cell neuroendocrine carcinoma Diseases 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 206010033898 parapsoriasis Diseases 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
- 210000004214 philadelphia chromosome Anatomy 0.000 description 1
- 230000001885 phytohemagglutinin Effects 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 108010026466 polyproline Proteins 0.000 description 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000007390 skin biopsy Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 206010062113 splenic marginal zone lymphoma Diseases 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000004960 subcellular localization Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 201000007954 uterine fibroid Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20020132A FI20020132A7 (fi) | 2002-01-24 | 2002-01-24 | Diagnostisia ja terapeuttisia menetelmiä |
| FI20020132 | 2002-01-24 | ||
| FI20021617 | 2002-09-10 | ||
| FI20021617A FI113666B (fi) | 2002-01-24 | 2002-09-10 | Menetelmiä, joissa käytetään kromosomin 12 spesifisiä katkoskohtia ja/tai neuroninavigaattori 3 -geeniä ihon primaaristen T-solulymfoomien diagnosoimiseksi ja taudin etenemisen seuraamiseksi tai ennustamiseksi, sekä näiden katkoskohtien ja geenien käyttö |
| PCT/FI2003/000061 WO2003066898A1 (en) | 2002-01-24 | 2003-01-24 | A method for the diagnosis of lymphoproliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2474446A1 true CA2474446A1 (en) | 2003-08-14 |
Family
ID=26161265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2474446 Abandoned CA2474446A1 (en) | 2002-01-24 | 2003-01-24 | A method for the diagnosis of lymphoproliferative diseases |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7803532B2 (enExample) |
| EP (1) | EP1476567A1 (enExample) |
| JP (1) | JP4782378B2 (enExample) |
| AU (1) | AU2003201630A1 (enExample) |
| CA (1) | CA2474446A1 (enExample) |
| FI (1) | FI113666B (enExample) |
| WO (1) | WO2003066898A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0878552A1 (en) | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molecular detection of chromosome aberrations |
| JP2002513587A (ja) | 1998-05-04 | 2002-05-14 | ダコ エー エス | 染色体異常を検出するための方法およびプローブ |
| WO2007071829A2 (en) | 2005-12-22 | 2007-06-28 | Dermagene Oy | Methods and means related to diseases |
| JP5523103B2 (ja) * | 2006-11-13 | 2014-06-18 | ヘルシンギン・ユリオピストン・ラハストト | 第１２染色体における遺伝子異常を含む方法および使用 |
| ES2534769T3 (es) | 2007-09-20 | 2015-04-28 | Valipharma | Diagnóstico de linfoma de linfocitos B |
| WO2009126804A2 (en) * | 2008-04-11 | 2009-10-15 | The Regents Of The University Of Colorado, A Body Corporate | Expression of kir in human cancer cells as a biomarker for immuno-escape and cancer metastasis |
| CA2740351A1 (en) * | 2008-10-20 | 2010-04-29 | Pharmatest Services Ltd. | Methods and uses involving genetic aberrations of nav3 and aberrant expression of multiple genes |
| EP4034567A4 (en) * | 2019-09-23 | 2023-07-05 | Neonc Technologies, Inc. | PHARMACEUTICAL COMPOSITIONS WITH POH DERIVATIVES |
| JP7258224B2 (ja) | 2020-03-16 | 2023-04-14 | 株式会社マンダム | Ｔ細胞性リンパ腫の指標の検出方法、及びその利用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6007994A (en) * | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
| ES2534769T3 (es) * | 2007-09-20 | 2015-04-28 | Valipharma | Diagnóstico de linfoma de linfocitos B |
-
2002
- 2002-09-10 FI FI20021617A patent/FI113666B/fi not_active IP Right Cessation
-
2003
- 2003-01-24 JP JP2003566246A patent/JP4782378B2/ja not_active Expired - Fee Related
- 2003-01-24 AU AU2003201630A patent/AU2003201630A1/en not_active Abandoned
- 2003-01-24 CA CA 2474446 patent/CA2474446A1/en not_active Abandoned
- 2003-01-24 WO PCT/FI2003/000061 patent/WO2003066898A1/en not_active Ceased
- 2003-01-24 US US10/502,638 patent/US7803532B2/en not_active Expired - Fee Related
- 2003-01-24 EP EP03700329A patent/EP1476567A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US7803532B2 (en) | 2010-09-28 |
| EP1476567A1 (en) | 2004-11-17 |
| US20050221309A1 (en) | 2005-10-06 |
| JP2005518790A (ja) | 2005-06-30 |
| WO2003066898A1 (en) | 2003-08-14 |
| FI20021617A0 (fi) | 2002-09-10 |
| AU2003201630A1 (en) | 2003-09-02 |
| FI113666B (fi) | 2004-05-31 |
| FI20021617A7 (fi) | 2003-07-25 |
| JP4782378B2 (ja) | 2011-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Koike Folgueira et al. | Gene expression profile associated with response to doxorubicin-based therapy in breast cancer | |
| Mok et al. | Molecular cloning of differentially expressed genes in human epithelial ovarian cancer | |
| US6342483B1 (en) | Method for detection and treatment of breast cancer | |
| US8715960B2 (en) | Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor | |
| Nanus et al. | Infrequent ras oncogene point mutations in renal cell carcinoma | |
| JP2001524802A (ja) | ２０ｑ１３アンプリコンからの遺伝子及びそれらの使用 | |
| Ishii et al. | Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay | |
| US7803532B2 (en) | Method for the diagnosis of lymphoproliferative diseases | |
| Dockhorn-Dworniczak et al. | Assessment of molecular genetic detection of chromosome translocations in the differential diagnosis of pediatric sarcomas | |
| US5892010A (en) | Genes from the 20Q13 amplicon and their uses | |
| Choi et al. | Identification of differentially expressed genes using annealing control primer-based GeneFishing in human squamous cell cervical carcinoma | |
| US7214488B2 (en) | Detection of MECT1-MAML2 fusion products | |
| EP0966531B1 (en) | Tazarotene-induced gene 3 (tig3) | |
| US20030171273A1 (en) | Novel transcription factor, BP1 | |
| WO2014207170A1 (en) | Methods for monitoring treatment response and relapse in ovarian cancer | |
| JP2009077714A (ja) | 腫瘍老化遺伝子の発現を同定および調節するための試薬および方法 | |
| KR101492024B1 (ko) | 전이성 뇌종양 진단용 마커 | |
| US20040253211A1 (en) | Method for diagnosing and treating cancer | |
| KR20140014360A (ko) | 이상 미토콘드리아 디엔에이, 관련된 융합 전사물 및 번역 산물 및 이에 대한 하이브리드화 탐침 | |
| ES2319533T3 (es) | Diagnostico del riesgo de cancer de pecho. | |
| López-Terrada et al. | Genetics and molecular biology of bone and soft tissue tumors | |
| Tanaka et al. | Detection of translocation 8; 21 on interphase cells from acute myelocytic leukemia by fluorescence in situ hybridization and its clinical application | |
| EP3013974A1 (en) | Screening, diagnosis, prognostication and treatment of ovarian cancer | |
| Hashimoto et al. | Clinical relevance of the SYT-SSX fusion gene in synovial sarcoma | |
| Lindeman et al. | Molecular Pathology of Soft Tissue and Bone Tumors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140124 |