CA2472633C - S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer - Google Patents

S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Download PDF

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Publication number
CA2472633C
CA2472633C CA2472633A CA2472633A CA2472633C CA 2472633 C CA2472633 C CA 2472633C CA 2472633 A CA2472633 A CA 2472633A CA 2472633 A CA2472633 A CA 2472633A CA 2472633 C CA2472633 C CA 2472633C
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CA
Canada
Prior art keywords
cancer
cooh
compound
mer1
significant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2472633A
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English (en)
French (fr)
Other versions
CA2472633A1 (en
Inventor
Ralph A. Zingaro
Emil L. Freireich
Hatice Duzkale
Hagop Kantarjian
Srdan Verstovsek
Merida Sotelo-Lerma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University System
University of Texas System
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Texas A&M University System
University of Texas System
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Application filed by Texas A&M University System, University of Texas System filed Critical Texas A&M University System
Publication of CA2472633A1 publication Critical patent/CA2472633A1/en
Application granted granted Critical
Publication of CA2472633C publication Critical patent/CA2472633C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2472633A 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer Expired - Fee Related CA2472633C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34649202P 2002-01-07 2002-01-07
US60/346,492 2002-01-07
PCT/US2003/000281 WO2003057012A2 (en) 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Publications (2)

Publication Number Publication Date
CA2472633A1 CA2472633A1 (en) 2003-07-17
CA2472633C true CA2472633C (en) 2014-07-08

Family

ID=23359639

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2472633A Expired - Fee Related CA2472633C (en) 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Country Status (6)

Country Link
US (4) US6911471B2 (https=)
EP (3) EP1474128B1 (https=)
JP (4) JP4571408B2 (https=)
AU (1) AU2003207455B2 (https=)
CA (1) CA2472633C (https=)
WO (1) WO2003057012A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1474128B1 (en) * 2002-01-07 2016-06-01 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid, s-dimethylarsino-2-thiobenzoic acid, s-(dimethylarsino)glutathione as treatments for cancer
AU2011204901B2 (en) * 2004-07-16 2013-09-12 Board Of Regents, The University Of Texas System Compounds and methods for treatment of cancer
TWI411431B (zh) * 2004-07-16 2013-10-11 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
JP4994374B2 (ja) * 2005-07-29 2012-08-08 ジオファーム オンコロジー， インコーポレイテッド がんを治療するための化合物および方法
CN101395166B (zh) * 2006-01-13 2014-07-09 得克萨斯州A&M大学系统 用于治疗癌症的化合物和方法
TW200829261A (en) * 2006-09-29 2008-07-16 Ziopharm Oncology Inc Method for controlling angiogenesis in animals
EP2069371B1 (en) * 2006-11-01 2013-03-13 NewSouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof
CN101903029B (zh) * 2007-11-02 2012-09-26 Zio医药肿瘤学公司 使用有机砷化物的联合治疗
WO2009075870A1 (en) * 2007-12-12 2009-06-18 Ziopharm Oncology, Inc. Compounds and methods for the treatment of cancer
WO2009153131A1 (en) * 2008-05-28 2009-12-23 Basf Se Means and methods for assessing liver enzyme induction
PT2321012T (pt) 2008-08-20 2019-01-11 Solasia Pharma K K Compostos organoarsénicos e métodos para o tratamento de cancro
JP5469779B2 (ja) * 2010-04-19 2014-04-16 エスアールアイ インターナショナル 多発性骨髄腫の治療のための組成物および方法
CN105899486A (zh) * 2013-12-05 2016-08-24 日本苏爱康制药有限公司 用于治疗癌症的化合物和方法
CN112941027B (zh) * 2021-03-19 2021-11-02 苏州大学 二甲基亚胂酸致人角质形成细胞恶性转化细胞株及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2349729A (en) * 1940-08-24 1944-05-23 Parke Davis & Co Therapeutic arsenic preparation
US2701812A (en) * 1951-06-26 1955-02-08 Dainippon Pharmaceutical Co Diarylarsenious acid derivatives and the preparation thereof
DE3229565A1 (de) * 1982-08-07 1984-02-16 Etschenberg, Eugen, Dr., 5000 Köln Arsenhaltige nucleoside
FR2640269B1 (fr) * 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
US6875451B2 (en) 1997-10-15 2005-04-05 Polarx Biopharmaceuticals Inc. Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
TR200002243T2 (tr) 1997-11-10 2000-12-21 Memorial Sloan-Kettering Cancer Center Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı.
CN1233476A (zh) * 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
US6191123B1 (en) 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
AUPQ296799A0 (en) 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
US7022315B2 (en) 2000-04-26 2006-04-04 Oregon Health & Science University Administration of a thiol-based chemoprotectant compound
AUPR379801A0 (en) 2001-03-19 2001-04-12 Unisearch Limited Use of a substantially cell membrane impermeable compound for treating arthritis
AUPR598901A0 (en) 2001-06-28 2001-07-19 Unisearch Limited Inhibition of angiogenesis by targeting protein tyrosine phosphatases
EP1411876B1 (en) 2001-07-06 2009-10-28 Cochlear Limited Configuration of implanted devices
EP1474128B1 (en) 2002-01-07 2016-06-01 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid, s-dimethylarsino-2-thiobenzoic acid, s-(dimethylarsino)glutathione as treatments for cancer
EP1563099B1 (en) 2002-11-07 2009-07-22 Newsouth Innovations Pty Limited Induction of the mitochondrial permeability transition
TWI411431B (zh) 2004-07-16 2013-10-11 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
EP2069371B1 (en) 2006-11-01 2013-03-13 NewSouth Innovations Pty Limited Organo-arsenoxide compounds and use thereof

Also Published As

Publication number Publication date
EP2420229A1 (en) 2012-02-22
EP1474128A4 (en) 2006-05-03
US20040034095A1 (en) 2004-02-19
WO2003057012A2 (en) 2003-07-17
WO2003057012A3 (en) 2004-07-08
JP2005527487A (ja) 2005-09-15
WO2003057012A8 (en) 2004-04-01
EP2462932A1 (en) 2012-06-13
US6911471B2 (en) 2005-06-28
US6995188B2 (en) 2006-02-07
JP5603593B2 (ja) 2014-10-08
JP2010090149A (ja) 2010-04-22
EP1474128A2 (en) 2004-11-10
US20060189687A1 (en) 2006-08-24
US20050131062A1 (en) 2005-06-16
US20080090904A1 (en) 2008-04-17
AU2003207455B2 (en) 2007-09-20
AU2003207455A2 (en) 2003-07-24
EP1474128B1 (en) 2016-06-01
US7619000B2 (en) 2009-11-17
JP2015120745A (ja) 2015-07-02
JP4571408B2 (ja) 2010-10-27
AU2003207455A1 (en) 2003-07-24
CA2472633A1 (en) 2003-07-17
JP2013237701A (ja) 2013-11-28

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HK1166959A (en) S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
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Zingaro et al. S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
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