CA2471436C - Derives d'acide barbiturique non sedatifs - Google Patents

Derives d'acide barbiturique non sedatifs Download PDF

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Publication number
CA2471436C
CA2471436C CA2471436A CA2471436A CA2471436C CA 2471436 C CA2471436 C CA 2471436C CA 2471436 A CA2471436 A CA 2471436A CA 2471436 A CA2471436 A CA 2471436A CA 2471436 C CA2471436 C CA 2471436C
Authority
CA
Canada
Prior art keywords
lower alkyl
phenyl
substituted
benzyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2471436A
Other languages
English (en)
Other versions
CA2471436A1 (fr
Inventor
Dainel A. Moros
Daniella Gutman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taro Pharmaceutical Industries Ltd
Original Assignee
Taro Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taro Pharmaceutical Industries Ltd filed Critical Taro Pharmaceutical Industries Ltd
Publication of CA2471436A1 publication Critical patent/CA2471436A1/fr
Application granted granted Critical
Publication of CA2471436C publication Critical patent/CA2471436C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • C07D239/64—Salts of organic bases; Organic double compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention se rapporte à des nouveaux dérivés d'acide barbiturique non sédatifs, à des compositions pharmaceutiques contenant ces dérivés et à des procédés de neuroprotection dans des cas d'ischémie cérébrale, de traumatisme crânien et d'autres troubles neurologiques aigus, ainsi qu'à des procédés de prévention des lésions neuronales qui en résultent. L'invention se rapporte également à l'utilisation de dérivés d'acide barbiturique non sédatifs administrés à une dose efficace pour produire des concentrations sanguines et des concentrations cérébrales de ces médicaments et/ou de leurs métabolites actifs suffisantes pour obtenir un effet thérapeutique.
CA2471436A 2002-01-30 2003-01-30 Derives d'acide barbiturique non sedatifs Expired - Fee Related CA2471436C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35227302P 2002-01-30 2002-01-30
US60/352,273 2002-01-30
PCT/US2003/002638 WO2003063872A1 (fr) 2002-01-30 2003-01-30 Derives d'acide barbiturique non sedatifs

Publications (2)

Publication Number Publication Date
CA2471436A1 CA2471436A1 (fr) 2003-08-07
CA2471436C true CA2471436C (fr) 2011-10-11

Family

ID=27663075

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2471436A Expired - Fee Related CA2471436C (fr) 2002-01-30 2003-01-30 Derives d'acide barbiturique non sedatifs

Country Status (6)

Country Link
EP (1) EP1485101A4 (fr)
JP (1) JP2005516052A (fr)
CN (2) CN1291720C (fr)
CA (1) CA2471436C (fr)
IL (1) IL163168A (fr)
WO (1) WO2003063872A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7683071B2 (en) 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
US6756379B2 (en) 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
BR0317289A (pt) 2002-12-11 2005-11-08 Taro Pharma Ind Método para tratar distúrbios do movimento usando derivados do ácido barbitúrico
EP1625848A1 (fr) * 2004-08-10 2006-02-15 Taro Pharmaceuticals North America, Inc. Composition et procédé pour améliorer l'administration de l'acide 5,5-diphénylbarbiturique
JP2015092251A (ja) * 2010-10-07 2015-05-14 富士フイルム株式会社 偏光板保護フィルム、偏光板および液晶表示装置
GB201115937D0 (en) 2011-09-14 2011-10-26 Univ Aberdeen 18F-labelled compounds for use as positron emission imaging agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE946804C (de) * 1952-02-28 1956-08-09 Emanuel Merck Ohg Verfahren zur Herstellung von schwefelhaltigen Abkoemmlingen der Barbitursaeure
DE1103339B (de) * 1959-02-04 1961-03-30 Chemische Werke Radebeul Veb Verfahren zur Herstellung von in 5-Stellung crotylierten, basisch substituierten Barbitursaeure-derivaten
DE1100639B (de) * 1959-03-24 1961-03-02 Chemische Werke Radebeul Veb Verfahren zur Herstellung von basisch substituierten Barbitursaeure-derivaten
US3711607A (en) * 1971-03-17 1973-01-16 Kendall & Co N,n -dihalomethyl phenobarbital for the treatment of convulsions
US3900475A (en) * 1972-06-26 1975-08-19 Kendall & Co Certain phenobarbital salts
IL69722A (en) * 1983-09-14 1986-09-30 Taro Pharma Ind Oxopyrimidine derivatives and pharmaceutical compositions containing them
US4833148A (en) * 1987-04-09 1989-05-23 Washington University Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury
US5474990A (en) * 1989-10-20 1995-12-12 Olney; John W. Barbiturates as safening agents in conjunction with NMDA antagonists
US6093820A (en) * 1997-10-02 2000-07-25 Taro Pharmaceutical Industries Ltd. Method and reagents for N-alkylating ureides
CA2306170A1 (fr) * 2000-04-18 2001-10-18 Kenneth Curry Nouveaux derives amines et carboxyles de l'acide barbiturique
AU2001280778B2 (en) * 2000-07-26 2004-09-02 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents

Also Published As

Publication number Publication date
CN1625401A (zh) 2005-06-08
CN1896084A (zh) 2007-01-17
IL163168A (en) 2012-01-31
WO2003063872A1 (fr) 2003-08-07
EP1485101A1 (fr) 2004-12-15
EP1485101A4 (fr) 2006-04-12
JP2005516052A (ja) 2005-06-02
CN1291720C (zh) 2006-12-27
CA2471436A1 (fr) 2003-08-07

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MKLA Lapsed

Effective date: 20150130