IL163168A - Non-sedative barbiturate which provides a neuroprotective effect for protection from a neurological damage - Google Patents

Non-sedative barbiturate which provides a neuroprotective effect for protection from a neurological damage

Info

Publication number
IL163168A
IL163168A IL163168A IL16316804A IL163168A IL 163168 A IL163168 A IL 163168A IL 163168 A IL163168 A IL 163168A IL 16316804 A IL16316804 A IL 16316804A IL 163168 A IL163168 A IL 163168A
Authority
IL
Israel
Prior art keywords
protection
provides
neuroprotective effect
neurological damage
sedative barbiturate
Prior art date
Application number
IL163168A
Original Assignee
Taro Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taro Pharma Ind filed Critical Taro Pharma Ind
Publication of IL163168A publication Critical patent/IL163168A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • C07D239/64—Salts of organic bases; Organic double compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL163168A 2002-01-30 2004-07-22 Non-sedative barbiturate which provides a neuroprotective effect for protection from a neurological damage IL163168A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35227302P 2002-01-30 2002-01-30
PCT/US2003/002638 WO2003063872A1 (en) 2002-01-30 2003-01-30 Non-sedating barbituric acid derivatives

Publications (1)

Publication Number Publication Date
IL163168A true IL163168A (en) 2012-01-31

Family

ID=27663075

Family Applications (1)

Application Number Title Priority Date Filing Date
IL163168A IL163168A (en) 2002-01-30 2004-07-22 Non-sedative barbiturate which provides a neuroprotective effect for protection from a neurological damage

Country Status (6)

Country Link
EP (1) EP1485101A4 (en)
JP (1) JP2005516052A (en)
CN (2) CN1291720C (en)
CA (1) CA2471436C (en)
IL (1) IL163168A (en)
WO (1) WO2003063872A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756379B2 (en) 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
US7683071B2 (en) 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
JP4739760B2 (en) 2002-12-11 2011-08-03 タロー・ファーマシューティカル・インダストリーズ・リミテッド Method for treating movement disorders using barbituric acid derivatives
EP1625848A1 (en) * 2004-08-10 2006-02-15 Taro Pharmaceuticals North America, Inc. Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid
JP2015092251A (en) * 2010-10-07 2015-05-14 富士フイルム株式会社 Polarizing plate protective film, polarizing plate and liquid crystal display device
GB201115937D0 (en) 2011-09-14 2011-10-26 Univ Aberdeen 18F-labelled compounds for use as positron emission imaging agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE946804C (en) * 1952-02-28 1956-08-09 Emanuel Merck Ohg Process for the production of sulfur-containing extracts of barbituric acid
DE1103339B (en) * 1959-02-04 1961-03-30 Chemische Werke Radebeul Veb Process for the preparation of 5-position crotylated, basic substituted barbituric acid derivatives
DE1100639B (en) * 1959-03-24 1961-03-02 Chemische Werke Radebeul Veb Process for the preparation of basic substituted barbituric acid derivatives
US3711607A (en) * 1971-03-17 1973-01-16 Kendall & Co N,n -dihalomethyl phenobarbital for the treatment of convulsions
US3900475A (en) * 1972-06-26 1975-08-19 Kendall & Co Certain phenobarbital salts
IL69722A (en) * 1983-09-14 1986-09-30 Taro Pharma Ind Oxopyrimidine derivatives and pharmaceutical compositions containing them
US4833148A (en) * 1987-04-09 1989-05-23 Washington University Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury
US5474990A (en) * 1989-10-20 1995-12-12 Olney; John W. Barbiturates as safening agents in conjunction with NMDA antagonists
US6093820A (en) * 1997-10-02 2000-07-25 Taro Pharmaceutical Industries Ltd. Method and reagents for N-alkylating ureides
CA2306170A1 (en) * 2000-04-18 2001-10-18 Kenneth Curry Novel amino, carboxy derivatives of barbituric acid
DE60132337T2 (en) * 2000-07-26 2009-02-12 Taro Pharmaceutical Industries Ltd. NON-SEDANT BARBITURATE COMPOUNDS AS NEUROPROTECTIVE ACTIVE SUBSTANCES

Also Published As

Publication number Publication date
EP1485101A4 (en) 2006-04-12
CN1291720C (en) 2006-12-27
CN1896084A (en) 2007-01-17
JP2005516052A (en) 2005-06-02
CA2471436C (en) 2011-10-11
CN1625401A (en) 2005-06-08
WO2003063872A1 (en) 2003-08-07
EP1485101A1 (en) 2004-12-15
CA2471436A1 (en) 2003-08-07

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees