CA2471127A1 - Methode anti-sens de modulation de la reponse des recepteurs d'oestrogenes (er.alpha. et/ou er.beta.) - Google Patents
Methode anti-sens de modulation de la reponse des recepteurs d'oestrogenes (er.alpha. et/ou er.beta.) Download PDFInfo
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- CA2471127A1 CA2471127A1 CA002471127A CA2471127A CA2471127A1 CA 2471127 A1 CA2471127 A1 CA 2471127A1 CA 002471127 A CA002471127 A CA 002471127A CA 2471127 A CA2471127 A CA 2471127A CA 2471127 A1 CA2471127 A1 CA 2471127A1
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- Prior art keywords
- antisense oligonucleotide
- seq
- beta
- antisense
- estradiol
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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Abstract
La présente invention concerne de nouveaux oligonucléotides anti-sens ciblant les gènes et les ARNs messagers codant pour les récepteurs d'oestrogènes (ER) alpha et/ou bêta mammifères et modulant les réponses des récepteurs. Ces oligonucléotides anti-sens peuvent être utilisés seuls ou en combinaison avec le 17 bêta oestradiol ou un composé associé (génistéine, dérivés d'oestradiol...) afin d'améliorer la stabilisation des plaques, la cicatrisation vasculaire et la récupération endothéliale suite à une lésion vasculaire. L'invention concerne également des méthodes de conception et d'essai des oligonucléotides anti-sens. Ces oligonucléotides peuvent être utilisés pour moduler les effets bénéfiques associés aux récepteurs d'oestrogènes sur la cicatrisation vasculaire, par exemple, la resténose ou la stabilisation des plaques, chez les mammifères. La présente invention concerne en outre des compositions et des formulations pharmaceutiques comprenant les nouveaux oligonucléotides anti-sens de la présente invention, et destinées à être utilisées dans le traitement des mammifères atteints d'une maladie ou de troubles caractérisés par l'athérosclérose, la vulnérabilité ou la déstabilisation des plaques ou une rupture ou l'usure pathologique des plaques, y compris une lésion spontanée ou provoquée.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002471127A CA2471127A1 (fr) | 2001-12-21 | 2002-12-20 | Methode anti-sens de modulation de la reponse des recepteurs d'oestrogenes (er.alpha. et/ou er.beta.) |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002365811A CA2365811A1 (fr) | 2001-12-21 | 2001-12-21 | Nouvelle therapie genique utilisant la strategie anti-sens pour les recepteurs estrogeniques (er .alpha. et/ou er .beta.) afin d'optimiser la regeneration vasculaire et la cardioprotection a la suite d'une lesion va sculaire |
| CA2,365,811 | 2001-12-21 | ||
| CA002471127A CA2471127A1 (fr) | 2001-12-21 | 2002-12-20 | Methode anti-sens de modulation de la reponse des recepteurs d'oestrogenes (er.alpha. et/ou er.beta.) |
| PCT/CA2002/002000 WO2003056010A2 (fr) | 2001-12-21 | 2002-12-20 | Methode anti-sens de modulation de la reponse des recepteurs d'oestrogenes (er $g(a) et/ou er $g(b)) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2471127A1 true CA2471127A1 (fr) | 2003-07-10 |
Family
ID=33098714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002471127A Abandoned CA2471127A1 (fr) | 2001-12-21 | 2002-12-20 | Methode anti-sens de modulation de la reponse des recepteurs d'oestrogenes (er.alpha. et/ou er.beta.) |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2471127A1 (fr) |
-
2002
- 2002-12-20 CA CA002471127A patent/CA2471127A1/fr not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |