CA2471119A1 - Genes et proteines lipase - Google Patents

Genes et proteines lipase Download PDF

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Publication number
CA2471119A1
CA2471119A1 CA002471119A CA2471119A CA2471119A1 CA 2471119 A1 CA2471119 A1 CA 2471119A1 CA 002471119 A CA002471119 A CA 002471119A CA 2471119 A CA2471119 A CA 2471119A CA 2471119 A1 CA2471119 A1 CA 2471119A1
Authority
CA
Canada
Prior art keywords
seq
lpdl
lpdlr
sequence
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002471119A
Other languages
English (en)
Inventor
A. Keith Stewart
Lap-Chee Tsui
Xiao-Yan Wen
Robert A. Hegele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2471119A1 publication Critical patent/CA2471119A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Les protéines lipase jouent un rôle important dans le métabolisme des lipoprotéines et des lipides des tissus et du plasma et assurent l'hydrolyse de lipides tels que des triglycérides. Diverses maladies sont associées à la fonction lipase : carence en lipase, athérosclérose, stéatose hépatique et dyslipidémies - hypercholestérolemie, hypertriglycéridémie, dyslipidémie mixte (combinée) - états carencés en lipides et lipoprotéines, et/ou tout autre troubles du métabolisme des lipides et lipoprotéines affectant les tissus et plasmas. L'invention concerne deux nouvelles protéines lipase (LPDL et LPDLR) ainsi que les acides nucléiques codant pour lesdites protéines et les séquences régulatrices commandant leur expression génique. L'invention concerne l'utilisation des acides nucléiques LPDL et/ou LPDLR ou de leurs protéines pour la modulation du processus cellulaire dans les états pathologiques ou dans l'homéostase normale de l'énergie. Cette invention concerne également les modulateurs, anticorps, oligonucléotides antisens de ces gènes et protéines ainsi que des analyses diagnostiques, la recherche systématique de mutations, la thérapie génique, l'utilisation de promoteurs pour la commande de l'expression génique, et leur utilisation industrielle dans l'industrie alimentaire et la gestion des déchets. L'invention concerne également des procédés de criblage de médicaments pour LPDL et LPDLR, leur application thérapeutique chez l'homme et leur utilisation sous forme de compositions pharmaceutiques.
CA002471119A 2001-12-21 2002-12-23 Genes et proteines lipase Abandoned CA2471119A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34178601P 2001-12-21 2001-12-21
US60/341,786 2001-12-21
US34660302P 2002-01-10 2002-01-10
US60/346,603 2002-01-10
PCT/CA2002/001998 WO2003055995A2 (fr) 2001-12-21 2002-12-23 Genes et proteines lipase

Publications (1)

Publication Number Publication Date
CA2471119A1 true CA2471119A1 (fr) 2003-07-10

Family

ID=26992663

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002471119A Abandoned CA2471119A1 (fr) 2001-12-21 2002-12-23 Genes et proteines lipase

Country Status (4)

Country Link
EP (1) EP1492873A2 (fr)
AU (1) AU2002351616A1 (fr)
CA (1) CA2471119A1 (fr)
WO (1) WO2003055995A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015141137A (ja) * 2014-01-29 2015-08-03 国立大学法人大阪大学 小腸由来ｈｄｌの取得方法、小腸由来ｈｄｌの評価方法、小腸由来ｈｄｌ増加作用を有する化合物のスクリーニング方法並びに前記化合物を含む小腸由来ｈｄｌ増加薬及び家族性高コレステロール血症治療薬
CN106884008B (zh) * 2015-12-16 2021-09-24 丰益(上海)生物技术研发中心有限公司 磷脂酶、编码基因及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003525575A (ja) * 1998-05-07 2003-09-02 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 分泌蛋白およびそれらをコードするポリヌクレオチド
AU2001243142A1 (en) * 2000-02-03 2001-08-14 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002024898A2 (fr) * 2000-09-25 2002-03-28 Millennium Pharmaceuticals, Inc. Nouvelle lipase humaine 47647 et utilisations
EP1329501A4 (fr) * 2000-10-11 2004-09-01 Mochida Pharm Co Ltd Nouvelle phospholipase a1 (pla1)
JP2005503112A (ja) * 2001-02-06 2005-02-03 インサイト・ゲノミックス・インコーポレイテッド 脂質結合分子

Also Published As

Publication number Publication date
AU2002351616A1 (en) 2003-07-15
WO2003055995A2 (fr) 2003-07-10
WO2003055995A3 (fr) 2003-11-20
EP1492873A2 (fr) 2005-01-05
AU2002351616A8 (en) 2003-07-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued