EP1492873A2 - Genes et proteines lipase - Google Patents
Genes et proteines lipaseInfo
- Publication number
- EP1492873A2 EP1492873A2 EP02787289A EP02787289A EP1492873A2 EP 1492873 A2 EP1492873 A2 EP 1492873A2 EP 02787289 A EP02787289 A EP 02787289A EP 02787289 A EP02787289 A EP 02787289A EP 1492873 A2 EP1492873 A2 EP 1492873A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- seq
- lpdl
- lpdlr
- sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Les protéines lipase jouent un rôle important dans le métabolisme des lipoprotéines et des lipides des tissus et du plasma et assurent l'hydrolyse de lipides tels que des triglycérides. Diverses maladies sont associées à la fonction lipase : carence en lipase, athérosclérose, stéatose hépatique et dyslipidémies - hypercholestérolemie, hypertriglycéridémie, dyslipidémie mixte (combinée) - états carencés en lipides et lipoprotéines, et/ou tout autre troubles du métabolisme des lipides et lipoprotéines affectant les tissus et plasmas. L'invention concerne deux nouvelles protéines lipase (LPDL et LPDLR) ainsi que les acides nucléiques codant pour lesdites protéines et les séquences régulatrices commandant leur expression génique. L'invention concerne l'utilisation des acides nucléiques LPDL et/ou LPDLR ou de leurs protéines pour la modulation du processus cellulaire dans les états pathologiques ou dans l'homéostase normale de l'énergie. Cette invention concerne également les modulateurs, anticorps, oligonucléotides antisens de ces gènes et protéines ainsi que des analyses diagnostiques, la recherche systématique de mutations, la thérapie génique, l'utilisation de promoteurs pour la commande de l'expression génique, et leur utilisation industrielle dans l'industrie alimentaire et la gestion des déchets. L'invention concerne également des procédés de criblage de médicaments pour LPDL et LPDLR, leur application thérapeutique chez l'homme et leur utilisation sous forme de compositions pharmaceutiques.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34178601P | 2001-12-21 | 2001-12-21 | |
US341786P | 2001-12-21 | ||
US34660302P | 2002-01-10 | 2002-01-10 | |
US346603P | 2002-01-10 | ||
PCT/CA2002/001998 WO2003055995A2 (fr) | 2001-12-21 | 2002-12-23 | Genes et proteines lipase |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1492873A2 true EP1492873A2 (fr) | 2005-01-05 |
Family
ID=26992663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02787289A Withdrawn EP1492873A2 (fr) | 2001-12-21 | 2002-12-23 | Genes et proteines lipase |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1492873A2 (fr) |
AU (1) | AU2002351616A1 (fr) |
CA (1) | CA2471119A1 (fr) |
WO (1) | WO2003055995A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015141137A (ja) * | 2014-01-29 | 2015-08-03 | 国立大学法人大阪大学 | 小腸由来hdlの取得方法、小腸由来hdlの評価方法、小腸由来hdl増加作用を有する化合物のスクリーニング方法並びに前記化合物を含む小腸由来hdl増加薬及び家族性高コレステロール血症治療薬 |
CN106884008B (zh) * | 2015-12-16 | 2021-09-24 | 丰益(上海)生物技术研发中心有限公司 | 磷脂酶、编码基因及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2327457A1 (fr) * | 1998-05-07 | 1999-11-11 | Genetics Institute, Inc. | Proteines secretees et polynucleotides codant pour celles-ci |
AU2001243142A1 (en) * | 2000-02-03 | 2001-08-14 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
WO2002024898A2 (fr) * | 2000-09-25 | 2002-03-28 | Millennium Pharmaceuticals, Inc. | Nouvelle lipase humaine 47647 et utilisations |
US20040253221A1 (en) * | 2000-10-11 | 2004-12-16 | Hiroyuki Arai | Novel pla1 |
US20040086905A1 (en) * | 2001-02-06 | 2004-05-06 | Debopriya Das | Lipid-associated molecules |
-
2002
- 2002-12-23 EP EP02787289A patent/EP1492873A2/fr not_active Withdrawn
- 2002-12-23 AU AU2002351616A patent/AU2002351616A1/en not_active Abandoned
- 2002-12-23 WO PCT/CA2002/001998 patent/WO2003055995A2/fr not_active Application Discontinuation
- 2002-12-23 CA CA002471119A patent/CA2471119A1/fr not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO03055995A3 * |
Also Published As
Publication number | Publication date |
---|---|
AU2002351616A8 (en) | 2003-07-15 |
CA2471119A1 (fr) | 2003-07-10 |
WO2003055995A2 (fr) | 2003-07-10 |
AU2002351616A1 (en) | 2003-07-15 |
WO2003055995A3 (fr) | 2003-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20040720 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO |
|
17Q | First examination report despatched |
Effective date: 20070917 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090310 |