CA2470235C - Compositions pharmaceutiques comprenant de la ghreline non acylee et utilisations therapeutiques de ces compositions - Google Patents
Compositions pharmaceutiques comprenant de la ghreline non acylee et utilisations therapeutiques de ces compositions Download PDFInfo
- Publication number
- CA2470235C CA2470235C CA2470235A CA2470235A CA2470235C CA 2470235 C CA2470235 C CA 2470235C CA 2470235 A CA2470235 A CA 2470235A CA 2470235 A CA2470235 A CA 2470235A CA 2470235 C CA2470235 C CA 2470235C
- Authority
- CA
- Canada
- Prior art keywords
- ghrelin
- administration
- unacylated ghrelin
- unacylated
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical class C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title claims abstract description 123
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- WZHKXNSOCOQYQX-FUAFALNISA-N (2s)-6-amino-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Chemical compound C([C@H](N)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CN=CN1 WZHKXNSOCOQYQX-FUAFALNISA-N 0.000 description 7
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- -1 n-octanoyl ester Chemical class 0.000 description 1
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- 229940127017 oral antidiabetic Drugs 0.000 description 1
- 230000001956 orexigenic effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne des compositions contenant de la ghréline non acylée et des dérivés de celle-ci, ainsi que leurs utilisations dans le contrôle de la glycémie chez des patients d'âge mûr, chez des patients présentant une déficience en hormone de croissance, chez des patients diabétiques et chez des patients obèses.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2470235A CA2470235C (fr) | 2001-12-18 | 2002-12-18 | Compositions pharmaceutiques comprenant de la ghreline non acylee et utilisations therapeutiques de ces compositions |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2365704 | 2001-12-18 | ||
| CA2,365,704 | 2001-12-18 | ||
| PCT/CA2002/001964 WO2003051389A2 (fr) | 2001-12-18 | 2002-12-18 | Compositions pharmaceutiques comprenant de la ghreline non acylee et utilisations therapeutiques de ces compositions |
| CA2470235A CA2470235C (fr) | 2001-12-18 | 2002-12-18 | Compositions pharmaceutiques comprenant de la ghreline non acylee et utilisations therapeutiques de ces compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2470235A1 CA2470235A1 (fr) | 2003-06-26 |
| CA2470235C true CA2470235C (fr) | 2012-02-07 |
Family
ID=32851583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2470235A Expired - Fee Related CA2470235C (fr) | 2001-12-18 | 2002-12-18 | Compositions pharmaceutiques comprenant de la ghreline non acylee et utilisations therapeutiques de ces compositions |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2470235C (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666833B2 (en) | 2001-12-18 | 2010-02-23 | Alizé Pharma SAS | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
| US7485620B2 (en) | 2001-12-18 | 2009-02-03 | Alizé Pharma SAS | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof |
| CA2543507C (fr) | 2003-10-24 | 2012-05-01 | Theratechnologies Inc. | Utilisation de compositions de ghreline et de ghreline non acylee dans des etats pathologiques lies a l'insuline |
| ES2538111T3 (es) | 2007-05-31 | 2015-06-17 | Alizé Pharma SAS | Grelina no acilada como agente terapéutico en el tratamiento de trastornos metabólicos |
| US8318664B2 (en) | 2007-05-31 | 2012-11-27 | Alize Pharma Sas | Unacylated ghrelin fragments as therapeutic agent in the treatment of obesity |
| US8476408B2 (en) | 2008-06-13 | 2013-07-02 | Alize Pharma Sas | Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease |
| ES2705499T3 (es) | 2011-12-15 | 2019-03-25 | Millendo Therapeutics Sas | Fragmentos de ghrelina no acilada para usar en el tratamiento del síndrome de Prader-Willi |
-
2002
- 2002-12-18 CA CA2470235A patent/CA2470235C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2470235A1 (fr) | 2003-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20201218 |