CA2468248C - Pregnane steroids for use in the treatment of cns disorders - Google Patents
Pregnane steroids for use in the treatment of cns disorders Download PDFInfo
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- CA2468248C CA2468248C CA2468248A CA2468248A CA2468248C CA 2468248 C CA2468248 C CA 2468248C CA 2468248 A CA2468248 A CA 2468248A CA 2468248 A CA2468248 A CA 2468248A CA 2468248 C CA2468248 C CA 2468248C
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- Prior art keywords
- 3beta
- 5alpha
- hydroxy
- pregnan
- steroid
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0104423A SE0104423D0 (sv) | 2001-12-27 | 2001-12-27 | Pregnane steroids and their use in the treatment of CNS disorders |
| SE0104423-9 | 2001-12-27 | ||
| PCT/SE2002/002423 WO2003059357A1 (en) | 2001-12-27 | 2002-12-20 | Pregnane steroids for use in the treatment of cns disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2468248A1 CA2468248A1 (en) | 2003-07-24 |
| CA2468248C true CA2468248C (en) | 2011-08-16 |
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Country Status (10)
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| US (2) | US7960367B2 (https=) |
| EP (2) | EP1458399B1 (https=) |
| JP (2) | JP2005519893A (https=) |
| CN (3) | CN101601674A (https=) |
| AU (3) | AU2002359202C1 (https=) |
| CA (1) | CA2468248C (https=) |
| DK (1) | DK1458399T3 (https=) |
| ES (1) | ES2394639T3 (https=) |
| SE (1) | SE0104423D0 (https=) |
| WO (1) | WO2003059357A1 (https=) |
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| RU2413516C2 (ru) * | 2004-11-18 | 2011-03-10 | Умекрин Аб | Гамк-стероидные антагонисты и их применение в лечении нарушений цнс |
| WO2006054938A1 (en) * | 2004-11-18 | 2006-05-26 | Umecrine Ab | Gaba-steroid antagonists and their use for the treatment of cns disorders |
| DK2097437T3 (en) | 2006-11-21 | 2015-06-29 | Umecrine Cognition Ab | THE USE OF PREGNANCY AND ANDROSTANOSTEROIDS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CNS DISEASES |
| US20090269795A1 (en) * | 2007-03-09 | 2009-10-29 | The Research Foundation Of State University Of New York | Mutant alpha4betadelta GABAA receptor and methods of treating anxiety or irritability |
| CN101585862B (zh) * | 2008-05-20 | 2014-12-17 | 梅克芳股份公司 | 甾族化合物 |
| HUE027298T2 (en) | 2010-01-14 | 2016-10-28 | Asarina Pharma Ab | Pharmaceutical composition containing developed storage and dissolution properties containing 3-beta-hydroxy-5-alpha-pregnan-20-one |
| AU2012260955B2 (en) * | 2011-05-20 | 2017-08-17 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Antagonists of CB1 receptor. |
| AU2013351190B2 (en) | 2012-11-28 | 2018-03-29 | Alienor Farma | 3-(4'-substituted)-benzyl-ether derivatives of pregnenolone |
| AU2015212606B2 (en) * | 2014-01-29 | 2019-11-21 | Umecrine Cognition Ab | Steroid compound for use in the treatment of hepatic encephalopathy |
| JOP20200195A1 (ar) * | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| AR103384A1 (es) | 2015-01-12 | 2017-05-03 | Umecrine Cognition Ab | 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA |
| US10278977B2 (en) | 2016-06-06 | 2019-05-07 | Umecrine Cognition Ab | Methods for treating hypersomnolence |
| DK3565528T3 (da) * | 2017-01-09 | 2025-05-26 | Relmada Therapeutics Inc | Injicerbare suspensioner |
| EP3579842A4 (en) | 2017-02-10 | 2020-12-23 | Asarina Pharma AB | 3-BETA-HYDROXY-5-ALPHA-PRÉGNAN-20-ONE FOR USE IN THE TREATMENT OF ESSENTIAL TREMMENTS |
| JP7179739B2 (ja) | 2017-02-10 | 2022-11-29 | アサリナ ファーマ アーベー | 医学的治療における使用のための３－β－ヒドロキシ－５－α－プレグナン－２０－オン |
| MX2020010219A (es) | 2018-04-05 | 2020-11-09 | Asarina Pharma Aps | Antagonistas de gaba-a para tratar trastornos por abstinencia de sustancia. |
| US11969434B1 (en) | 2022-08-29 | 2024-04-30 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
| US20250387409A1 (en) * | 2021-11-10 | 2025-12-25 | Umecrine Cognition Ab | 3-beta-hydroxy-3-alpha-ethyl steroids for modulation of the alpha-3 subtype of the gabaa receptor |
| WO2023083978A1 (en) | 2021-11-10 | 2023-05-19 | Umecrine Ab | 3.alpha.-substituted 3.beta.-hydroxy 17-oximated androstane compound for modulation of the alpha-3 subtype of the gaba-a receptor |
| EP4429669A1 (en) | 2021-11-10 | 2024-09-18 | Umecrine AB | Steroid as a modulator of gabaa receptor |
| US12186327B2 (en) | 2022-08-29 | 2025-01-07 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
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| US5232917A (en) | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5439900A (en) | 1993-02-25 | 1995-08-08 | Bukusoglu; Cuneyt | Methods and compositions for providing analgesia and enhanced anesthesia |
| US5939545A (en) | 1994-02-14 | 1999-08-17 | Cocensys, Inc. | Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series |
| US5767117A (en) | 1994-11-18 | 1998-06-16 | The General Hospital Corporation | Method for treating vascular headaches |
| WO1998050042A1 (en) * | 1997-05-02 | 1998-11-12 | American Home Products Corporation | Pregnan-3-ol-20-ones |
| CA2289108A1 (en) * | 1997-05-02 | 1998-11-12 | American Home Products Corporation | Salts of 5.alpha.-pregn-16-en-3.beta.-ol-20-one 3-sulphate ester with progestin activity |
| BR9809435A (pt) * | 1997-05-02 | 2000-06-13 | American Home Prod | Sais farmaceuticamente aceitáveis de 3-sulfato de 5alfa-pregnan-3beta, 16alfa-diol-20-ona úteis como progestinas e distúrbios do snc |
| CN1270718C (zh) * | 1998-03-11 | 2006-08-23 | 托布乔恩·贝克斯托罗姆 | 表别孕烷醇酮在制备治疗甾族化合物诱导的疾病的药物中的应用 |
| AU751708B2 (en) | 1998-10-13 | 2002-08-22 | Wyeth | Pregnane glucuronides |
| US20020072509A1 (en) * | 2000-10-11 | 2002-06-13 | Stein Donald Gerald | Methods for the treatment of a traumatic central nervous system injury |
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Also Published As
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|---|---|
| EP1458399A1 (en) | 2004-09-22 |
| EP2275109A3 (en) | 2011-10-12 |
| JP2010065052A (ja) | 2010-03-25 |
| JP2005519893A (ja) | 2005-07-07 |
| EP2275109A2 (en) | 2011-01-19 |
| JP5289281B2 (ja) | 2013-09-11 |
| AU2002359202B2 (en) | 2009-02-19 |
| WO2003059357A1 (en) | 2003-07-24 |
| CN1607954A (zh) | 2005-04-20 |
| AU2009201956A2 (en) | 2010-02-18 |
| US20050222099A1 (en) | 2005-10-06 |
| CN101601675A (zh) | 2009-12-16 |
| AU2009201956B2 (en) | 2010-11-25 |
| SE0104423D0 (sv) | 2001-12-27 |
| US20110098259A1 (en) | 2011-04-28 |
| EP2275109B1 (en) | 2013-07-24 |
| AU2002359202A1 (en) | 2003-07-30 |
| CN101601674A (zh) | 2009-12-16 |
| CA2468248A1 (en) | 2003-07-24 |
| ES2394639T3 (es) | 2013-02-04 |
| US7960367B2 (en) | 2011-06-14 |
| CN100518741C (zh) | 2009-07-29 |
| US8119619B2 (en) | 2012-02-21 |
| EP1458399B1 (en) | 2012-08-08 |
| AU2009201956A1 (en) | 2009-06-11 |
| DK1458399T3 (da) | 2012-11-12 |
| AU2002359202C1 (en) | 2011-03-31 |
| AU2009201951A1 (en) | 2009-06-04 |
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