CA2465738C - Unsaturated 1-amino-alkylcyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists - Google Patents

Unsaturated 1-amino-alkylcyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists Download PDF

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Publication number
CA2465738C
CA2465738C CA002465738A CA2465738A CA2465738C CA 2465738 C CA2465738 C CA 2465738C CA 002465738 A CA002465738 A CA 002465738A CA 2465738 A CA2465738 A CA 2465738A CA 2465738 C CA2465738 C CA 2465738C
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linear
branched lower
compound
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disease
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CA002465738A
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English (en)
French (fr)
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CA2465738A1 (en
Inventor
Christopher Graham Raphael Parsons
Markus Henrich
Wojciech Danysy
Ivars Kalvinsh
Valerjans Kauss
Aigars Jirgensons
Markus Gold
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Merz Pharma GmbH and Co KGaA
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Merz Pharma GmbH and Co KGaA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
CA002465738A 2001-11-07 2002-11-07 Unsaturated 1-amino-alkylcyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists Expired - Fee Related CA2465738C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35097401P 2001-11-07 2001-11-07
US60/350,974 2001-11-07
US33785801P 2001-11-08 2001-11-08
US60/337,858 2001-11-08
PCT/GB2002/005038 WO2003040084A1 (en) 2001-11-07 2002-11-07 Unsaturated 1-amino-alkylcyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists

Publications (2)

Publication Number Publication Date
CA2465738A1 CA2465738A1 (en) 2003-05-15
CA2465738C true CA2465738C (en) 2009-01-20

Family

ID=26990903

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002465738A Expired - Fee Related CA2465738C (en) 2001-11-07 2002-11-07 Unsaturated 1-amino-alkylcyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists

Country Status (16)

Country Link
US (1) US6828462B2 (OSRAM)
EP (1) EP1442008A1 (OSRAM)
JP (1) JP2005508381A (OSRAM)
KR (1) KR100655975B1 (OSRAM)
CN (1) CN100390131C (OSRAM)
AU (1) AU2002337389B2 (OSRAM)
CA (1) CA2465738C (OSRAM)
CO (1) CO5570696A2 (OSRAM)
EA (1) EA010177B1 (OSRAM)
GE (1) GEP20053714B (OSRAM)
HU (1) HUP0402028A3 (OSRAM)
IL (1) IL161801A0 (OSRAM)
MX (1) MXPA04004412A (OSRAM)
NO (1) NO20042338L (OSRAM)
PL (1) PL370245A1 (OSRAM)
WO (1) WO2003040084A1 (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW593223B (en) * 2000-06-20 2004-06-21 Merz Pharma Gmbh & Co Kgaa 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists
AU2004258751C1 (en) * 2003-07-28 2008-07-17 Merz Pharma Gmbh & Co. Kgaa The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity
AR046314A1 (es) * 2003-11-05 2005-11-30 Merz Pharma Gmbh & Co Kgaa Composiciones que comprenden ciclohexilaminas y aminoadamantanos
TW200531680A (en) * 2004-03-03 2005-10-01 Merz Pharma Gmbh & Co Kgaa Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease
ES2483126T3 (es) * 2004-06-17 2014-08-05 Merz Pharma Gmbh & Co. Kgaa Formulaciones de formas de dosificación de neramexano
US7427601B2 (en) * 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
US7893289B2 (en) * 2007-02-21 2011-02-22 Ssv Therapeutics, Inc. Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids
EP2111858A1 (en) 2008-04-25 2009-10-28 EPFL Ecole Polytechnique Fédérale de Lausanne Novel treatment for alzheimer's disease
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
PE20110565A1 (es) 2008-08-12 2011-09-02 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
EA201391017A1 (ru) 2011-01-10 2014-04-30 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
US20150182546A1 (en) * 2013-03-15 2015-07-02 Mitochondrial Concepts Llc Therapeutic agent for enhancing mitochondrial function
WO2018129609A1 (en) * 2017-01-10 2018-07-19 Owen-Barry Pharmaceuticals Inc. Anticonvulsant compounds
AU2024287244B1 (en) * 2024-12-28 2025-08-21 Lai, Meng Hong MR A device for relieving constipation and its preparation method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267366A (en) * 1977-12-14 1981-05-12 Scm Corporation Cyclic terpenoid amines, their preparation and uses
UA61962C2 (uk) * 1997-06-30 2003-12-15 Мерц Фарма Гмбх Унд Ко. Кгаа Сполука 1-аміноалкілциклогексану, фармацевтична композиція на її основі та спосіб лікування
US6071966A (en) 1997-06-30 2000-06-06 Merz + Co. Gmbh & Co. 1-amino-alkylcyclohexane NMDA receptor antagonists

Also Published As

Publication number Publication date
JP2005508381A (ja) 2005-03-31
EA010177B1 (ru) 2008-06-30
WO2003040084A1 (en) 2003-05-15
PL370245A1 (en) 2005-05-16
HK1075037A1 (zh) 2005-12-02
IL161801A0 (en) 2005-11-20
GEP20053714B (en) 2005-12-26
CA2465738A1 (en) 2003-05-15
CO5570696A2 (es) 2005-10-31
AU2002337389B2 (en) 2005-12-08
HUP0402028A2 (hu) 2005-01-28
EA200400637A1 (ru) 2004-10-28
MXPA04004412A (es) 2005-05-16
US6828462B2 (en) 2004-12-07
US20030166634A1 (en) 2003-09-04
KR20050044354A (ko) 2005-05-12
KR100655975B1 (ko) 2006-12-08
HUP0402028A3 (en) 2008-03-28
CN100390131C (zh) 2008-05-28
EP1442008A1 (en) 2004-08-04
CN1602292A (zh) 2005-03-30
NO20042338L (no) 2004-07-21

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