CA2461812C - 3-(arylamino)methylene-1,3-dihydro-2h-indol-2-ones as kinase inhibitors - Google Patents
3-(arylamino)methylene-1,3-dihydro-2h-indol-2-ones as kinase inhibitors Download PDFInfo
- Publication number
- CA2461812C CA2461812C CA2461812A CA2461812A CA2461812C CA 2461812 C CA2461812 C CA 2461812C CA 2461812 A CA2461812 A CA 2461812A CA 2461812 A CA2461812 A CA 2461812A CA 2461812 C CA2461812 C CA 2461812C
- Authority
- CA
- Canada
- Prior art keywords
- dihydro
- indol
- methylene
- fluoro
- phenylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32581901P | 2001-09-27 | 2001-09-27 | |
| US32581501P | 2001-09-27 | 2001-09-27 | |
| US60/325,819 | 2001-09-27 | ||
| US60/325,815 | 2001-09-27 | ||
| PCT/US2002/030882 WO2003027102A1 (en) | 2001-09-27 | 2002-09-27 | 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
Publications (2)
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| CA2461812A1 CA2461812A1 (en) | 2003-04-03 |
| CA2461812C true CA2461812C (en) | 2011-09-20 |
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| CA2461812A Expired - Fee Related CA2461812C (en) | 2001-09-27 | 2002-09-27 | 3-(arylamino)methylene-1,3-dihydro-2h-indol-2-ones as kinase inhibitors |
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| Country | Link |
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| US (7) | US20030225152A1 (enExample) |
| EP (1) | EP1430048A1 (enExample) |
| JP (2) | JP2005508336A (enExample) |
| AU (1) | AU2002341881B2 (enExample) |
| CA (1) | CA2461812C (enExample) |
| WO (1) | WO2003027102A1 (enExample) |
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| US20030225152A1 (en) * | 2001-09-27 | 2003-12-04 | Andrews Steven W. | 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
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| DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
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2002
- 2002-09-27 US US10/259,703 patent/US20030225152A1/en not_active Abandoned
- 2002-09-27 CA CA2461812A patent/CA2461812C/en not_active Expired - Fee Related
- 2002-09-27 JP JP2003530690A patent/JP2005508336A/ja active Pending
- 2002-09-27 AU AU2002341881A patent/AU2002341881B2/en not_active Ceased
- 2002-09-27 EP EP02776036A patent/EP1430048A1/en not_active Withdrawn
- 2002-09-27 US US10/256,879 patent/US6765012B2/en not_active Expired - Fee Related
- 2002-09-27 WO PCT/US2002/030882 patent/WO2003027102A1/en not_active Ceased
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2004
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- 2004-07-06 US US10/886,213 patent/US7098236B2/en not_active Expired - Lifetime
-
2005
- 2005-09-16 US US11/228,780 patent/US20060025413A1/en not_active Abandoned
- 2005-11-15 US US11/274,681 patent/US7414054B2/en not_active Expired - Lifetime
-
2006
- 2006-03-31 US US11/396,036 patent/US20060194863A1/en not_active Abandoned
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2010
- 2010-01-25 JP JP2010013326A patent/JP2010116411A/ja active Pending
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| WO2003027102A1 (en) | 2003-04-03 |
| US20030225152A1 (en) | 2003-12-04 |
| US20030199478A1 (en) | 2003-10-23 |
| US7098236B2 (en) | 2006-08-29 |
| US20050228036A1 (en) | 2005-10-13 |
| AU2002341881B2 (en) | 2008-05-08 |
| US7414054B2 (en) | 2008-08-19 |
| CA2461812A1 (en) | 2003-04-03 |
| EP1430048A1 (en) | 2004-06-23 |
| US6765012B2 (en) | 2004-07-20 |
| JP2005508336A (ja) | 2005-03-31 |
| US20040198720A1 (en) | 2004-10-07 |
| US20060063940A1 (en) | 2006-03-23 |
| US7015220B2 (en) | 2006-03-21 |
| US20060025413A1 (en) | 2006-02-02 |
| US20060194863A1 (en) | 2006-08-31 |
| JP2010116411A (ja) | 2010-05-27 |
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