CA2460843A1 - Agents porogenes pour ciments orthopediques - Google Patents

Agents porogenes pour ciments orthopediques Download PDF

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Publication number
CA2460843A1
CA2460843A1 CA002460843A CA2460843A CA2460843A1 CA 2460843 A1 CA2460843 A1 CA 2460843A1 CA 002460843 A CA002460843 A CA 002460843A CA 2460843 A CA2460843 A CA 2460843A CA 2460843 A1 CA2460843 A1 CA 2460843A1
Authority
CA
Canada
Prior art keywords
bmp
bone
pore
gdf
xaa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002460843A
Other languages
English (en)
Inventor
Paresh S. Dalal
Tracy J. Landeryou
Carol Ann Toth
Shailesh C. Kulkarni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2460843A1 publication Critical patent/CA2460843A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)

Abstract

Composition précurseur d'os contenant un mélange de ciment et un agent porogène est conçue pour exécuter un implant osseux. Cet agent porogène, de préférence, présente une dimension de particule de 20-500 microns. Dans un mode de réalisation préféré, la proportion de cet agent porogène est 7-40 % (w/w). Cette composition peut également contenir un agent bioactif, de préférence, une protéine morphogénique osseuse ou un acide nucléique codant ladite protéine (BMP) et encapsulé dans l'agent porogène. On peut moduler les caractéristiques de moulage de cette composition par l'intermédiaire d'un apport de liant. L'invention concerne également une trousse et un implant comprenant ladite composition précurseur d'os. Elle concerne également un dispositif prothétique implantable composé d'un implant prothétique possédant une zone superficielle dans laquelle est placé le matériau précurseur d'os. Cette trousse et ces dispositifs peuvent, de plus, contenir un ou plusieurs éléments supplémentaires, tels qu'un agent bioactif et un liant. Elle concerne enfin des procédés servant à induire la formation osseuse et à administrer cet agent bioactif.
CA002460843A 2001-09-21 2002-09-20 Agents porogenes pour ciments orthopediques Abandoned CA2460843A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96042101A 2001-09-21 2001-09-21
US09/960,421 2001-09-21
PCT/US2002/029966 WO2003024316A2 (fr) 2001-09-21 2002-09-20 Agents porogenes pour ciments orthopediques

Publications (1)

Publication Number Publication Date
CA2460843A1 true CA2460843A1 (fr) 2003-03-27

Family

ID=25503137

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002460843A Abandoned CA2460843A1 (fr) 2001-09-21 2002-09-20 Agents porogenes pour ciments orthopediques

Country Status (5)

Country Link
EP (1) EP1446445A4 (fr)
JP (1) JP2005508217A (fr)
AU (1) AU2002327007B2 (fr)
CA (1) CA2460843A1 (fr)
WO (1) WO2003024316A2 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524335B2 (en) 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
US7857860B2 (en) 2003-04-30 2010-12-28 Therics, Llc Bone void filler and method of manufacture
ATE490745T1 (de) 2002-03-29 2010-12-15 Wright Medical Tech Inc Knochentransplantat-ersatzzusammensetzung
US7291179B2 (en) 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
US8124118B2 (en) 2003-10-22 2012-02-28 Lidds Ab Composition comprising biodegradable hydrating ceramics for controlled drug delivery
FR2869544B1 (fr) * 2004-05-03 2006-07-21 Centre Nat Rech Scient Cnrse Composition pour ciment injectable, utile comme substitut osseux
US7749268B2 (en) 2004-05-26 2010-07-06 Warsaw Orthopedic, Inc. Methods for treating the spine
US7250550B2 (en) 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
US8852240B2 (en) 2004-10-25 2014-10-07 Kieran Murphy, Llc Methods and compositions for fostering and preserving bone growth
US8545866B2 (en) 2004-10-29 2013-10-01 Smith & Nephew, Inc. Bioabsorbable polymers
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
WO2007030616A2 (fr) 2005-09-09 2007-03-15 Wright Medical Technology, Inc. Ciment de substitution composite pour greffe osseuse et articles produits a partir de ce ciment
AU2006326271B2 (en) * 2005-12-14 2011-02-24 Scil Technology Gmbh A moldable biomaterial for bone regeneration
US8101198B2 (en) 2006-07-26 2012-01-24 The Regents Of The University Of California Osteogenic enhancer composition
EP1891984A1 (fr) * 2006-08-24 2008-02-27 Graftys Ciment phosphocalcique apatitique macroporeux et résorbable
CN101663043B (zh) * 2007-04-27 2014-03-12 尤尼基因实验室公司 促进和保持骨生长的方法和组合物
WO2010055483A2 (fr) 2008-11-12 2010-05-20 Engqvist Haakan Ciments hydrauliques, procédés et produits
FR2948573B1 (fr) * 2009-07-31 2011-11-18 Adocia Nouvelle forme d'administration de complexes de proteines osteogeniques
KR20120018202A (ko) 2009-05-26 2012-02-29 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 파이브로모듈린 펩타이드
TWI579007B (zh) 2010-07-02 2017-04-21 艾格諾福斯保健公司 骨再生材料之用途
AU2011291537B2 (en) 2010-08-19 2016-06-02 The Regents Of The University Of California Compositions comprising perivascular stem cells and Nell-1 protein
EP2450064B1 (fr) * 2010-10-19 2014-04-09 National Cheng Kung University Formulation de ciment osseux et composites durcis de ciment osseux préparés avec cette formulation
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
ES2784859T3 (es) * 2012-12-14 2020-10-01 Ossdsign Ab Composiciones formadoras de cemento, cementos de monetíta, implantes y métodos para corregir los defectos óseos
CN103394120B (zh) * 2013-07-31 2015-01-28 华南理工大学 一种磷酸钙基复合微球支架及其制备方法
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
EP3352807A1 (fr) * 2015-09-23 2018-08-01 OssDsign AB Composition formant un ciment, ciments d'apatite, implants et procédés de correction d'anomalies osseuses
CN107303397B (zh) * 2016-04-20 2019-10-01 中国科学院化学研究所 一种具有生物活性的可注射复合骨水泥及其制备方法和用途
EP3468632B1 (fr) 2016-06-10 2022-12-14 DSM IP Assets B.V. Agent de remplissage de vide osseux durcissable
CN106806403B (zh) * 2017-02-17 2020-11-27 福建康是美生物科技有限公司 一种增加骨密度的中药复方组合物及其制备方法
WO2019048697A1 (fr) 2017-09-11 2019-03-14 Bone Support Ab Biomatériau de cryogel composite macroporeux et microporeux destiné à être utilisé dans la régénération osseuse
CN108114323A (zh) * 2018-01-24 2018-06-05 广西医科大学 一种多孔可注射的磷酸钙骨水泥复合物
TWI739485B (zh) * 2019-08-19 2021-09-11 喜樂醫療器材股份有限公司 止血方法
CN111790004A (zh) * 2020-06-17 2020-10-20 天津市康婷生物工程集团有限公司 一种通用型载药钙磷骨水泥多孔支架制备方法
CN114191619A (zh) * 2021-12-17 2022-03-18 苏州大学附属第一医院 具有微/纳复合拓扑结构的可注射多孔微球的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
CA2285329A1 (fr) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Matrices biodegradables a porosite ouverte et processus de fabrication
CN1286468C (zh) * 1997-04-30 2006-11-29 雷克特本克斯尔保健(英国)有限公司 含藻酸或藻酸盐的药物组合物
US6281257B1 (en) * 1998-04-27 2001-08-28 The Regents Of The University Of Michigan Porous composite materials
US6224635B1 (en) * 1998-11-06 2001-05-01 Hospital For Joint Diseases Implantation of surgical implants with calcium sulfate
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering

Also Published As

Publication number Publication date
JP2005508217A (ja) 2005-03-31
WO2003024316A3 (fr) 2003-12-31
AU2002327007B2 (en) 2005-10-20
EP1446445A2 (fr) 2004-08-18
EP1446445A4 (fr) 2007-04-04
WO2003024316A2 (fr) 2003-03-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued