CA2460005C - Enhancement of learning and memory and treatment of amnesia with the use of fused pyrazoles - Google Patents

Enhancement of learning and memory and treatment of amnesia with the use of fused pyrazoles Download PDF

Info

Publication number
CA2460005C
CA2460005C CA002460005A CA2460005A CA2460005C CA 2460005 C CA2460005 C CA 2460005C CA 002460005 A CA002460005 A CA 002460005A CA 2460005 A CA2460005 A CA 2460005A CA 2460005 C CA2460005 C CA 2460005C
Authority
CA
Canada
Prior art keywords
composition
compound
phenyl
memory
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002460005A
Other languages
English (en)
French (fr)
Other versions
CA2460005A1 (en
Inventor
Wen-Mei Fu
Keng-Chen Liang
Wei-Lin Chien
Sheng-Chu Kuo
Fang-Yuan Lee
Che-Ming Teng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carlsbad Technology Inc
Original Assignee
Carlsbad Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlsbad Technology Inc filed Critical Carlsbad Technology Inc
Publication of CA2460005A1 publication Critical patent/CA2460005A1/en
Application granted granted Critical
Publication of CA2460005C publication Critical patent/CA2460005C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002460005A 2001-09-14 2002-09-16 Enhancement of learning and memory and treatment of amnesia with the use of fused pyrazoles Expired - Fee Related CA2460005C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32238901P 2001-09-14 2001-09-14
US60/322,389 2001-09-14
US10/242,826 2002-09-13
US10/242,826 US7049334B2 (en) 2001-09-14 2002-09-13 Enhancement of learning and memory and treatment of amnesia
PCT/US2002/029294 WO2003024397A2 (en) 2001-09-14 2002-09-16 Enhancement of learning and memory and treatment of amnesia

Publications (2)

Publication Number Publication Date
CA2460005A1 CA2460005A1 (en) 2003-03-27
CA2460005C true CA2460005C (en) 2008-12-02

Family

ID=26935379

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002460005A Expired - Fee Related CA2460005C (en) 2001-09-14 2002-09-16 Enhancement of learning and memory and treatment of amnesia with the use of fused pyrazoles

Country Status (10)

Country Link
US (1) US7049334B2 (https=)
EP (1) EP1425011B1 (https=)
JP (1) JP2005502722A (https=)
KR (1) KR100889515B1 (https=)
AT (1) ATE447405T1 (https=)
AU (1) AU2002327635B2 (https=)
CA (1) CA2460005C (https=)
DE (1) DE60234263D1 (https=)
NZ (1) NZ532022A (https=)
WO (1) WO2003024397A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077702A1 (en) * 2001-09-14 2004-04-22 Wen-Mei Fu Treatment of nuerodegenerative diseases
AU2004275694B2 (en) 2003-06-30 2008-03-06 Bizbiotech Co., Ltd. Compounds, compositions and methods
JP2005089457A (ja) * 2003-09-03 2005-04-07 Yung Shin Pharmaceutical Industry Co Ltd 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
US6984652B2 (en) 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
AU2007276763B2 (en) * 2006-07-24 2011-03-17 University Of Maryland, Baltimore Heme oxygenase inhibitors and methods of therapeutic use
EP2106445A2 (en) * 2006-12-01 2009-10-07 Loma Linda University Medical Center Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240947A (en) * 1992-11-30 1993-08-31 National Science Council 2,3,4,5-substituted furo[2,3-c]pyrazole derivatives
JP2928079B2 (ja) * 1994-02-14 1999-07-28 永信薬品工業股▲ふん▼有限公司 １−（置換ベンジル）−３−（置換アリール）縮合ピラゾール類、その製造法及びその用途
US7115661B1 (en) * 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
DE19642255A1 (de) * 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
DE19744026A1 (de) * 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
GB9920566D0 (en) * 1999-08-31 1999-11-03 Univ London Screen for axon viability
JP2004508279A (ja) * 2000-01-26 2004-03-18 シーダース　シナイ　メディカル　センター 薬剤を異常脳領域及び／又は悪性腫瘍にデリバリーするためにカリウムチャンネル活性化を用いる方法
AR031176A1 (es) * 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina

Also Published As

Publication number Publication date
EP1425011B1 (en) 2009-11-04
US20030105149A1 (en) 2003-06-05
EP1425011A2 (en) 2004-06-09
AU2002327635B2 (en) 2007-12-13
WO2003024397A3 (en) 2003-11-06
NZ532022A (en) 2005-12-23
CA2460005A1 (en) 2003-03-27
KR20040049307A (ko) 2004-06-11
DE60234263D1 (de) 2009-12-17
ATE447405T1 (de) 2009-11-15
WO2003024397A2 (en) 2003-03-27
KR100889515B1 (ko) 2009-03-19
US7049334B2 (en) 2006-05-23
JP2005502722A (ja) 2005-01-27
EP1425011A4 (en) 2007-09-19

Similar Documents

Publication Publication Date Title
JP4248239B2 (ja) プリン作用性レセプターアンタゴニストとしてのピロロ［２，３−ｄ］ピリミジンおよびそれらの使用
JP5702288B2 (ja) Ｎｍｄａレセプターモジュレータ及びその用途
KR20230121808A (ko) 약제학적 활성 화합물로서 칸나비노이드 유도체 및이의 제조 방법
DE60107435T2 (de) 2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission
JP2004517861A (ja) プリン作動性レセプターアンタゴニストとしてのピラゾロ［３，４−ｄ］ピリミジン誘導体およびそれらの使用
KR20170013890A (ko) Nmdar 조절 화합물의 조합물
JP2015007096A (ja) 運動障害の予防および／または治療剤
US20090088449A1 (en) 4-acylaminopyridine derivative mediated neurogenesis
KR101217353B1 (ko) 신생혈관 형성 방지 방법
CA2460005C (en) Enhancement of learning and memory and treatment of amnesia with the use of fused pyrazoles
US6319944B1 (en) Aryl amidines, compositions containing such compounds and methods of use
WO2001014383A1 (en) Remedies for neuropathic pain and model animals of neuropathic pain
AU2002327635A1 (en) Enhancement of learning and memory and treatment of amnesia
WO2009156680A2 (fr) Association d'un agoniste partiel des recepteurs nicotiniques et d'un inhibiteur d'acetylcholinesterase, composition pharmaceutique la contenant et son utilisation dans le traitement des troubles cognitifs
WO2011016952A1 (en) Compositions and methods for treating cancer
ES2643377T3 (es) Composición farmacéutica para prevenir o tratar degeneración macular
JPH10101566A (ja) 網膜保護剤
EP1512400B1 (en) Treatment of neurodegenerative diseases
CN1254241C (zh) 稠环吡唑化合物在制备增强学习和记忆及治疗遗忘症的药物中的用途
JP2003238405A (ja) 敗血症の処置に使用される薬剤組成物
US10870633B2 (en) Types of C-3 substituted kynurenic acid derivatives with improved neuroprotective activity
MX2008010252A (en) 4-acylaminopyridine derivative mediated neurogenesis

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed