CA2457516C - Detecteur pour spectrometre de masse - Google Patents
Detecteur pour spectrometre de masse Download PDFInfo
- Publication number
- CA2457516C CA2457516C CA2457516A CA2457516A CA2457516C CA 2457516 C CA2457516 C CA 2457516C CA 2457516 A CA2457516 A CA 2457516A CA 2457516 A CA2457516 A CA 2457516A CA 2457516 C CA2457516 C CA 2457516C
- Authority
- CA
- Canada
- Prior art keywords
- detector
- microchannel plate
- time
- detecting
- electrons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 142
- 230000005684 electric field Effects 0.000 claims description 66
- 239000002245 particle Substances 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 23
- 230000002123 temporal effect Effects 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 claims description 11
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 8
- 238000010265 fast atom bombardment Methods 0.000 claims description 6
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 6
- 238000009616 inductively coupled plasma Methods 0.000 claims description 6
- 238000001698 laser desorption ionisation Methods 0.000 claims description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 4
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 3
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 3
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 3
- 238000000451 chemical ionisation Methods 0.000 claims description 3
- 238000003795 desorption Methods 0.000 claims description 3
- 238000000132 electrospray ionisation Methods 0.000 claims description 3
- 238000004088 simulation Methods 0.000 description 21
- 230000004044 response Effects 0.000 description 15
- 238000009826 distribution Methods 0.000 description 14
- 238000011084 recovery Methods 0.000 description 11
- 230000001133 acceleration Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 238000010884 ion-beam technique Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000020169 heat generation Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000005405 multipole Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- 101100257835 Streptococcus pyogenes sspS gene Proteins 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 239000010406 cathode material Substances 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 239000005357 flat glass Substances 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005040 ion trap Methods 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J43/00—Secondary-emission tubes; Electron-multiplier tubes
- H01J43/04—Electron multipliers
- H01J43/06—Electrode arrangements
- H01J43/18—Electrode arrangements using essentially more than one dynode
- H01J43/24—Dynodes having potential gradient along their surfaces
- H01J43/246—Microchannel plates [MCP]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J43/00—Secondary-emission tubes; Electron-multiplier tubes
- H01J43/04—Electron multipliers
- H01J43/06—Electrode arrangements
- H01J43/18—Electrode arrangements using essentially more than one dynode
- H01J43/24—Dynodes having potential gradient along their surfaces
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/025—Detectors specially adapted to particle spectrometers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/244—Detection characterized by the detecting means
- H01J2237/2444—Electron Multiplier
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0303310.7 | 2003-02-13 | ||
| GB0303310A GB0303310D0 (en) | 2003-02-13 | 2003-02-13 | Mass spectrometer |
| GB0308592A GB0308592D0 (en) | 2003-02-13 | 2003-04-14 | Mass spectrometer |
| GB0308592.5 | 2003-04-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2457516A1 CA2457516A1 (fr) | 2004-08-13 |
| CA2457516C true CA2457516C (fr) | 2012-10-02 |
Family
ID=32031895
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2457522A Expired - Fee Related CA2457522C (fr) | 2003-02-13 | 2004-02-12 | Detecteur pour spectrometre de masse |
| CA2457516A Expired - Fee Related CA2457516C (fr) | 2003-02-13 | 2004-02-12 | Detecteur pour spectrometre de masse |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2457522A Expired - Fee Related CA2457522C (fr) | 2003-02-13 | 2004-02-12 | Detecteur pour spectrometre de masse |
Country Status (3)
| Country | Link |
|---|---|
| CA (2) | CA2457522C (fr) |
| DE (4) | DE202004002190U1 (fr) |
| GB (2) | GB2399677C (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0409118D0 (en) * | 2004-04-26 | 2004-05-26 | Micromass Ltd | Mass spectrometer |
| DE102011077057A1 (de) * | 2011-06-07 | 2012-12-13 | Siemens Aktiengesellschaft | Strahlungsdetektor und bildgebendes System |
| GB2515061A (en) * | 2013-06-12 | 2014-12-17 | Isis Innovation | Scintillator |
| CN106908484B (zh) * | 2017-01-18 | 2020-07-31 | 江苏大学 | 一种检测y型纸质微通道混合效率的装置和方法 |
| CN110703293B (zh) * | 2019-09-29 | 2020-12-29 | 中国科学院近代物理研究所 | 一种单个离子实时监测装置及方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2319196A1 (fr) * | 1975-07-25 | 1977-02-18 | Cameca | Dispositif de mesure precis des courants ioniques et spectrometre de masse utilisant un tel dispositif |
| JPS6240147A (ja) * | 1985-08-14 | 1987-02-21 | Shimadzu Corp | イオン検出装置 |
| DE3903750A1 (de) * | 1989-02-06 | 1990-08-16 | Eberhard Koehler | Anodenanordnung fuer einen orts- und zeitaufloesenden elektronendetektor, sowie detektoren damit |
| US4988867A (en) * | 1989-11-06 | 1991-01-29 | Galileo Electro-Optics Corp. | Simultaneous positive and negative ion detector |
| DE4019005C2 (de) * | 1990-06-13 | 2000-03-09 | Finnigan Mat Gmbh | Vorrichtungen zur Analyse von Ionen hoher Masse |
| US5268612A (en) * | 1991-07-01 | 1993-12-07 | Intevac, Inc. | Feedback limited microchannel plate |
| US5326978A (en) * | 1992-12-17 | 1994-07-05 | Intevac, Inc. | Focused electron-bombarded detector |
| DE4322104A1 (de) * | 1993-07-02 | 1995-01-19 | Bergmann Thorald | Detektor für Flugzeit-Massenspektrometer mit geringen Flugzeitfehlern bei gleichzeitig großer Öffnung |
| US5693946A (en) * | 1996-06-11 | 1997-12-02 | Trustees Of Boston University | Single photon imaging with a Bi-Linear charge-coupled device array |
| JP3270707B2 (ja) * | 1997-03-31 | 2002-04-02 | 株式会社日本ビーテック | イオン検出装置 |
| WO1999038190A2 (fr) * | 1998-01-23 | 1999-07-29 | Micromass Limited | Spectrometre de masse a temps de vol et detecteur double gain |
| JP2001273867A (ja) * | 2000-03-27 | 2001-10-05 | Jeol Ltd | マイクロチャンネル検出装置 |
| US6747271B2 (en) * | 2001-12-19 | 2004-06-08 | Ionwerks | Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisition |
| EP1573770B1 (fr) * | 2002-02-20 | 2013-06-26 | University of Washington | Instruments d'analyse utilisant un ensemble pseudo-aleatoire de sources, telles qu'un spectrometre de masse micro-usines |
-
2004
- 2004-02-12 GB GB0403184A patent/GB2399677C/en not_active Expired - Fee Related
- 2004-02-12 DE DE202004002190U patent/DE202004002190U1/de not_active Expired - Lifetime
- 2004-02-12 DE DE202004002189U patent/DE202004002189U1/de not_active Expired - Lifetime
- 2004-02-12 DE DE102004006998A patent/DE102004006998B4/de not_active Expired - Fee Related
- 2004-02-12 CA CA2457522A patent/CA2457522C/fr not_active Expired - Fee Related
- 2004-02-12 GB GB0403178A patent/GB2398924C/en not_active Expired - Fee Related
- 2004-02-12 DE DE102004006997A patent/DE102004006997B4/de not_active Expired - Fee Related
- 2004-02-12 CA CA2457516A patent/CA2457516C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB2399677C (en) | 2007-03-06 |
| CA2457522C (fr) | 2012-09-25 |
| DE102004006997B4 (de) | 2008-02-07 |
| GB2398924A (en) | 2004-09-01 |
| DE202004002190U1 (de) | 2004-07-15 |
| GB2399677B (en) | 2005-08-10 |
| GB0403178D0 (en) | 2004-03-17 |
| GB2398924C (en) | 2007-03-13 |
| CA2457516A1 (fr) | 2004-08-13 |
| GB0403184D0 (en) | 2004-03-17 |
| DE102004006998B4 (de) | 2008-01-03 |
| DE102004006997A1 (de) | 2004-09-16 |
| DE102004006998A1 (de) | 2004-10-07 |
| CA2457522A1 (fr) | 2004-08-13 |
| GB2399677A (en) | 2004-09-22 |
| DE202004002189U1 (de) | 2004-07-15 |
| GB2398924B (en) | 2006-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200212 |