CA2457432A1 - Method and system for profiling biological systems - Google Patents

Method and system for profiling biological systems Download PDF

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Publication number
CA2457432A1
CA2457432A1 CA002457432A CA2457432A CA2457432A1 CA 2457432 A1 CA2457432 A1 CA 2457432A1 CA 002457432 A CA002457432 A CA 002457432A CA 2457432 A CA2457432 A CA 2457432A CA 2457432 A1 CA2457432 A1 CA 2457432A1
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CA
Canada
Prior art keywords
analysis
data sets
correlation
sets
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA002457432A
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English (en)
French (fr)
Inventor
Jan Van Der Greef
Eric K. Neumann
Aram S. Adourian
Noubar B. Afeyan
Matej Oresic
Frederick E. Regnier
Elwin Robbert Verheij
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BG Medicine Inc
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Individual
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Publication of CA2457432A1 publication Critical patent/CA2457432A1/en
Abandoned legal-status Critical Current

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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0036Step by step routines describing the handling of the data generated during a measurement
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioethics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Signal Processing (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002457432A 2001-08-13 2002-08-13 Method and system for profiling biological systems Abandoned CA2457432A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31214501P 2001-08-13 2001-08-13
US60/312,145 2001-08-13
PCT/US2002/025734 WO2003017177A2 (en) 2001-08-13 2002-08-13 Method and system for profiling biological systems

Publications (1)

Publication Number Publication Date
CA2457432A1 true CA2457432A1 (en) 2003-02-27

Family

ID=23210073

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002457432A Abandoned CA2457432A1 (en) 2001-08-13 2002-08-13 Method and system for profiling biological systems

Country Status (6)

Country Link
US (3) US8068987B2 (enExample)
EP (1) EP1425695A2 (enExample)
JP (2) JP2005500543A (enExample)
CA (1) CA2457432A1 (enExample)
IL (1) IL160324A0 (enExample)
WO (1) WO2003017177A2 (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
MXPA02012167A (es) * 2000-06-19 2004-08-19 Correlogic Systems Inc Metodo heuristico de clasificacion.
KR101054732B1 (ko) * 2000-07-18 2011-08-05 더 유나이티드 스테이츠 오브 아메리카 애즈 리프리젠티드 바이 더 세크레터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 생물학적 데이터의 숨겨진 패턴에 근거한 생물학적 상태의 식별 방법
EP1425695A2 (en) 2001-08-13 2004-06-09 Beyong Genomics, Inc. Method and system for profiling biological systems
AR040712A1 (es) * 2002-07-29 2005-04-20 Correlogic Systems Inc Un metodo para inicialar un modelo de control para proceso de bioensayo
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
CA2637250A1 (en) 2002-12-09 2004-06-24 Ajinomoto Co., Inc. Apparatus and method for processing information concerning biological condition, system, program and recording medium for managing information concerning biological condition
US7457708B2 (en) * 2003-03-13 2008-11-25 Agilent Technologies Inc Methods and devices for identifying related ions from chromatographic mass spectral datasets containing overlapping components
AU2003901196A0 (en) * 2003-03-17 2003-04-03 Commonwealth Scientific And Industrial Research Organisation Analysis method
GB0307352D0 (en) * 2003-03-29 2003-05-07 Qinetiq Ltd Improvements in and relating to the analysis of compounds
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
DE112004000746B4 (de) * 2003-05-29 2014-09-25 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren und Vorrichtung zum Verarbeiten von LC-MS- oder LC-MS-/MS-Daten bei Stoffwechseluntersuchungen
CA2534336A1 (en) * 2003-08-01 2005-02-10 Correlogic Systems, Inc. Multiple high-resolution serum proteomic features for ovarian cancer detection
JP2007502992A (ja) * 2003-08-20 2007-02-15 ビージー メディシン, インコーポレイテッド 生物システムのプロファイリングのための方法およびシステム
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
EP1512970A1 (en) * 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
US7761239B2 (en) * 2003-12-11 2010-07-20 Correlogic Systems, Inc. Method of diagnosing biological states through the use of a centralized, adaptive model, and remote sample processing
CA2501003C (en) * 2004-04-23 2009-05-19 F. Hoffmann-La Roche Ag Sample analysis to provide characterization data
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
AU2006207954A1 (en) 2005-01-28 2006-08-03 Childrens Medical Center Corporation Methods for diagnosis and prognosis of epithelial cancers
EP1861704A2 (en) * 2005-02-09 2007-12-05 Correlogic Systems, Inc. Identification of bacteria and spores
WO2006098192A1 (ja) * 2005-03-16 2006-09-21 Ajinomoto Co., Inc. 生体状態評価装置、生体状態評価方法、生体状態評価システム、生体状態評価プログラム、評価関数作成装置、評価関数作成方法、評価関数作成プログラムおよび記録媒体
US20080312514A1 (en) * 2005-05-12 2008-12-18 Mansfield Brian C Serum Patterns Predictive of Breast Cancer
CA2772688A1 (en) 2005-09-12 2007-03-22 Phenomenome Discoveries Inc. Methods for the diagnosis of colorectal cancer and ovarian cancer health states
US20070162992A1 (en) * 2006-01-09 2007-07-12 Mcgill University Metabolomic determination in assisted reproductive technology
JP2009527735A (ja) 2006-02-17 2009-07-30 チルドレンズ メディカル センター コーポレーション 癌に対するバイオマーカーとしての遊離ngal
US7736905B2 (en) 2006-03-31 2010-06-15 Biodesix, Inc. Method and system for determining whether a drug will be effective on a patient with a disease
WO2007140270A2 (en) * 2006-05-25 2007-12-06 Vialogy Corp. Analyzing information gathered using multiple analytical techniques
WO2008100941A2 (en) * 2007-02-12 2008-08-21 Correlogic Systems Inc. A method for calibrating an analytical instrument
EP2538048B1 (en) 2007-03-30 2015-03-04 Continental Automotive Systems US, Inc. Reductant delivery unit for selective catalytic reduction
EP3666284A1 (en) 2007-06-22 2020-06-17 Children's Medical Center, Corp. Methods and uses thereof of a fragment of saposin a
EP2637020A3 (en) 2007-06-29 2014-01-08 Correlogic Systems Inc. Predictive markers for ovarian cancer
JP4983451B2 (ja) * 2007-07-18 2012-07-25 株式会社島津製作所 クロマトグラフ質量分析データ処理装置
US20100099135A1 (en) * 2008-10-22 2010-04-22 Mandy Katz-Jaffe Methods and assays for assessing the quality of embryos in assisted reproduction technology protocols
WO2010064413A1 (ja) * 2008-12-01 2010-06-10 国立大学法人山口大学 薬剤の作用・副作用予測システムとそのプログラム
CA3013992A1 (en) 2008-12-30 2010-07-08 Children's Medical Center Corporation Method of predicting acute appendicitis
WO2010079253A2 (es) 2009-01-09 2010-07-15 Proyecto De Biomedicina Cima, S.L. Biomarcadores para el diagnóstico de fibrosis
EP3366695B1 (en) 2009-12-17 2021-07-07 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
KR101149236B1 (ko) * 2010-04-09 2012-05-25 대한민국(농촌진흥청장) 크로마토그래피?질량분석을 이용한 인삼 연근 판별 방법
EP3293522A3 (en) * 2010-06-20 2018-05-02 Zora Biosciences OY Lipidomic biomarkers for identification of high-risk coronary artery disease patients
JP2013545439A (ja) 2010-09-17 2013-12-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 多能性幹細胞の有用性および安全性の特徴決定を行うための機能的ゲノミクスアッセイ
DE102010038014B4 (de) * 2010-10-06 2021-10-07 Numares Ag Verwendung spezifischer Substanzen als Marker zur Bestimmung des Risikos einer Nierenabstoßung
CN102478563B (zh) * 2010-11-25 2014-08-13 中国科学院大连化学物理研究所 一种用于研究转基因和非转基因水稻代谢差异的方法
CN103765212A (zh) 2011-06-27 2014-04-30 杰克逊实验室 治疗癌症和自体免疫性疾病的方法和组合物
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
AU2012340015B2 (en) 2011-11-14 2017-09-21 Alfasigma S.P.A. Assays for selecting a treatment regimen for a subject with depression and methods for treatment
CA2860226C (en) 2011-12-22 2022-10-18 Randolph S. Watnick Saposin-a derived peptides and uses thereof
CA2860558C (en) 2012-01-05 2021-03-02 Boston Medical Center Corporation Slit-robo signaling for diagnosis and treatment of kidney disease
EP3418397B1 (en) 2012-01-24 2020-10-07 CD Diagnostics, Inc. System for detecting infection in synovial fluid
CN103913698B (zh) * 2014-03-27 2016-07-06 西北工业大学 基于小波分形及核主元特征的开关电流电路故障诊断方法
US11624093B2 (en) 2014-04-24 2023-04-11 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
MX384423B (es) 2014-06-19 2025-03-14 Memorial Sloan Kettering Cancer Center Biomarcadores para la respuesta a inhibidores del mejorador del homólogo 2 de zeste (ezh2).
ES2825708T3 (es) 2014-07-17 2021-05-17 Univ Pennsylvania Métodos para usar exosomas para monitorizar el estado de órgano trasplantado
WO2017023929A1 (en) 2015-08-04 2017-02-09 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
US20200200735A9 (en) 2016-02-22 2020-06-25 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen
CN106022373B (zh) * 2016-05-18 2019-04-23 江南大学 一种基于广义均值典型相关分析的图像识别方法
CN109187614B (zh) * 2018-09-27 2020-03-06 厦门大学 基于核磁共振和质谱的代谢组学数据融合方法及其应用
AU2020326698A1 (en) 2019-08-05 2022-02-24 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
US12018279B2 (en) 2019-10-18 2024-06-25 The Trustees Of The University Of Pennsylvania Micro-engineered models of the human eye and methods of use
US20230374599A1 (en) 2020-10-19 2023-11-23 Alexander Gusev Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy
AU2022226999A1 (en) 2021-02-25 2023-10-05 Rein Therapeutics, Inc. Biomarkers for the treatment of interstitial lung disease
EP4074820A1 (en) 2021-04-16 2022-10-19 The Trustees of The University of Pennsylvania Micro-engineered models of the human eye and methods of use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194217B1 (en) 1980-01-14 2001-02-27 Esa, Inc. Method of diagnosing or categorizing disorders from biochemical profiles
US5644503A (en) 1994-03-28 1997-07-01 Hitachi, Ltd. Methods and apparatuses for analyzing multichannel chromatogram
JP3270290B2 (ja) * 1994-04-28 2002-04-02 株式会社日立製作所 マルチチャンネルクロマトグラムの解析方法及びデータ処理装置
US6031232A (en) * 1995-11-13 2000-02-29 Bio-Rad Laboratories, Inc. Method for the detection of malignant and premalignant stages of cervical cancer
US6699710B1 (en) 1998-02-25 2004-03-02 The United States Of America As Represented By The Department Of Health And Human Services Tumor tissue microarrays for rapid molecular profiling
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
WO1999050437A1 (en) * 1998-03-30 1999-10-07 Esa, Inc. Methodology for predicting and/or diagnosing disease
JP2002536664A (ja) * 1999-02-10 2002-10-29 オックスフォード ナチュラル プロダクツ ピーエルシー 薬用植物製品の品質管理及び標準化のためのプロセス
US6647341B1 (en) 1999-04-09 2003-11-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
AU2579401A (en) * 1999-12-17 2001-06-25 Johns Hopkins University, The Brain protein markers
WO2001067103A1 (en) 2000-03-06 2001-09-13 Bioseek, Inc. Function homology screening
GB0013007D0 (en) 2000-05-30 2000-07-19 Imperial College Characterization system and method
KR101054732B1 (ko) 2000-07-18 2011-08-05 더 유나이티드 스테이츠 오브 아메리카 애즈 리프리젠티드 바이 더 세크레터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 생물학적 데이터의 숨겨진 패턴에 근거한 생물학적 상태의 식별 방법
NL1016034C2 (nl) 2000-08-03 2002-02-08 Tno Werkwijze en systeem voor het identificeren en kwantificeren van chemische componenten van een te onderzoeken mengsel van materialen.
AU2001292846A1 (en) 2000-09-20 2002-04-29 Surromed, Inc. Biological markers for evaluating therapeutic treatment of inflammatory and autoimmune disorders
US20030130798A1 (en) 2000-11-14 2003-07-10 The Institute For Systems Biology Multiparameter integration methods for the analysis of biological networks
CA2429633A1 (en) 2000-11-16 2002-05-30 Ciphergen Biosystems, Inc. Method for analyzing mass spectra
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
GB0031566D0 (en) 2000-12-22 2001-02-07 Mets Ometrix Methods for spectral analysis and their applications
AU2002233310A1 (en) 2001-01-18 2002-07-30 Basf Aktiengesellschaft Method for metabolic profiling
WO2002086501A2 (en) 2001-04-23 2002-10-31 Metabometrix Limited Methods for analysis of spectral data and their applications: osteoporosis
US7901873B2 (en) 2001-04-23 2011-03-08 Tcp Innovations Limited Methods for the diagnosis and treatment of bone disorders
US20050037515A1 (en) 2001-04-23 2005-02-17 Nicholson Jeremy Kirk Methods for analysis of spectral data and their applications osteoporosis
WO2002099452A1 (en) 2001-06-04 2002-12-12 Metabometrix Limited Methods for spectral analysis and their applications: reliability assessment
US7343247B2 (en) 2001-07-30 2008-03-11 The Institute For Systems Biology Methods of classifying drug responsiveness using multiparameter analysis
EP1425695A2 (en) 2001-08-13 2004-06-09 Beyong Genomics, Inc. Method and system for profiling biological systems
US6873915B2 (en) 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
WO2003023366A2 (en) 2001-09-12 2003-03-20 The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Method and system for classifying a scenario
US20030078739A1 (en) 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US6835927B2 (en) 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
US6873914B2 (en) 2001-11-21 2005-03-29 Icoria, Inc. Methods and systems for analyzing complex biological systems
EP1327883A3 (en) 2002-01-10 2003-07-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Combined metabolomic, proteomic and transcriptomic analysis from one, single sample and suitable statistical evaluation of data
US7623969B2 (en) 2002-01-31 2009-11-24 The Institute For Systems Biology Gene discovery for the system assignment of gene function
AU2003239409A1 (en) 2002-05-09 2003-11-11 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
WO2003107270A2 (en) 2002-06-14 2003-12-24 Pfizer Limited Metabolic phenotyping
MXPA05005073A (es) 2002-11-12 2005-11-17 Becton Dickinson Co Diagnostico de la sepsis o sirs usando perfiles de biomarcadores.

Also Published As

Publication number Publication date
US8068987B2 (en) 2011-11-29
WO2003017177A2 (en) 2003-02-27
JP2005500543A (ja) 2005-01-06
US20050273275A1 (en) 2005-12-08
WO2003017177A3 (en) 2004-04-08
JP2009133867A (ja) 2009-06-18
EP1425695A2 (en) 2004-06-09
IL160324A0 (en) 2004-07-25
US20050283320A1 (en) 2005-12-22
US20030134304A1 (en) 2003-07-17

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