CA2457351A1 - Derives de quinazolinone - Google Patents

Derives de quinazolinone Download PDF

Info

Publication number
CA2457351A1
CA2457351A1 CA002457351A CA2457351A CA2457351A1 CA 2457351 A1 CA2457351 A1 CA 2457351A1 CA 002457351 A CA002457351 A CA 002457351A CA 2457351 A CA2457351 A CA 2457351A CA 2457351 A1 CA2457351 A1 CA 2457351A1
Authority
CA
Canada
Prior art keywords
pharmaceutically acceptable
acceptable salt
quinazolinone
group
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002457351A
Other languages
English (en)
Other versions
CA2457351C (fr
Inventor
Masami Muraoka
Kazuki Matsui
Takaaki Yamamoto
Koji Morishita
Masatoshi Yuri
Seiji Katayama
Naohito Ohashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2457351A1 publication Critical patent/CA2457351A1/fr
Application granted granted Critical
Publication of CA2457351C publication Critical patent/CA2457351C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne un isomère à activité optique d'un dérivé de quinazolinone représenté par la formule générale (1): (dans laquelle Y représente phényle ou alkyle C2-7; E représente CH= ou azote; et R représente alkyle C1-4, etc.) ou un sel pharmaceutiquement acceptable de l'isomère. Cet isomère et son sel présentent un antagonisme sélectif vis-à-vis du récepteur M3 de la muscarine et ils permettent de réduire la fréquence de la contraction rythmique de la vessie. L'isomère et son sel sont utilisés dans les traitements de la miction fréquente ou de l'incontinence urinaire.
CA002457351A 2001-08-09 2002-08-02 Derives de quinazolinone Expired - Fee Related CA2457351C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001-241955 2001-08-09
JP2001241955 2001-08-09
PCT/JP2002/007930 WO2003016299A1 (fr) 2001-08-09 2002-08-02 Dérivé de quinazolinone

Publications (2)

Publication Number Publication Date
CA2457351A1 true CA2457351A1 (fr) 2003-02-27
CA2457351C CA2457351C (fr) 2010-01-12

Family

ID=19072309

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002457351A Expired - Fee Related CA2457351C (fr) 2001-08-09 2002-08-02 Derives de quinazolinone

Country Status (13)

Country Link
US (1) US7329665B2 (fr)
EP (1) EP1424334B1 (fr)
JP (1) JP4087337B2 (fr)
KR (1) KR100824506B1 (fr)
CN (1) CN1307172C (fr)
AT (1) ATE376546T1 (fr)
CA (1) CA2457351C (fr)
DE (1) DE60223151T2 (fr)
DK (1) DK1424334T3 (fr)
ES (1) ES2295382T3 (fr)
PT (1) PT1424334E (fr)
TW (1) TWI308567B (fr)
WO (1) WO2003016299A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673353B2 (en) 2008-02-11 2014-03-18 Dainippon Sumitomo Pharma Co., Ltd Tablet having improved elution properties
EP2363397A4 (fr) 2008-11-07 2012-07-11 Dainippon Sumitomo Pharma Co Nouvel agent thérapeutique utile pour un symptôme du tractus urinaire inférieur
WO2016199161A2 (fr) * 2015-06-12 2016-12-15 Swati Vishal Jajodia Composition comprenant du pentosane polysulfate sodium à utiliser dans le traitement des symptômes de l'obstruction du col de la vessie et/ou d'un trouble du tractus urinaire inférieur

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE174908T1 (de) * 1993-05-26 1999-01-15 Sumitomo Pharma Chinazolinonderivate
JP4484368B2 (ja) * 1998-10-16 2010-06-16 大日本住友製薬株式会社 キナゾリノン誘導体

Also Published As

Publication number Publication date
KR20040020081A (ko) 2004-03-06
DK1424334T3 (da) 2008-02-11
PT1424334E (pt) 2008-01-10
US7329665B2 (en) 2008-02-12
DE60223151T2 (de) 2008-08-07
CN1538966A (zh) 2004-10-20
EP1424334A4 (fr) 2005-05-04
ATE376546T1 (de) 2007-11-15
CN1307172C (zh) 2007-03-28
US20050032819A1 (en) 2005-02-10
KR100824506B1 (ko) 2008-04-22
WO2003016299A1 (fr) 2003-02-27
TWI308567B (fr) 2009-04-11
JPWO2003016299A1 (ja) 2004-12-02
JP4087337B2 (ja) 2008-05-21
EP1424334B1 (fr) 2007-10-24
DE60223151D1 (de) 2007-12-06
EP1424334A1 (fr) 2004-06-02
ES2295382T3 (es) 2008-04-16
CA2457351C (fr) 2010-01-12

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20170802