CA2453510C - Treatment of fatigue and cognitive side effects associated with cancer, cancer treatments and menopause with d-threo-methyphenidate - Google Patents
Treatment of fatigue and cognitive side effects associated with cancer, cancer treatments and menopause with d-threo-methyphenidate Download PDFInfo
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- CA2453510C CA2453510C CA2453510A CA2453510A CA2453510C CA 2453510 C CA2453510 C CA 2453510C CA 2453510 A CA2453510 A CA 2453510A CA 2453510 A CA2453510 A CA 2453510A CA 2453510 C CA2453510 C CA 2453510C
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- 239000007787 solid Substances 0.000 description 1
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US09/903,803 | 2001-07-12 | ||
| US09/903,803 US6486177B2 (en) | 1995-12-04 | 2001-07-12 | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| PCT/US2002/022039 WO2003005962A2 (en) | 2001-07-12 | 2002-07-11 | Methods for treatment of cognitive and menopausal disorders with d-threo methylphenidate |
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| CA2453510A1 CA2453510A1 (en) | 2003-01-23 |
| CA2453510C true CA2453510C (en) | 2012-03-20 |
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| CA2453510A Expired - Fee Related CA2453510C (en) | 2001-07-12 | 2002-07-11 | Treatment of fatigue and cognitive side effects associated with cancer, cancer treatments and menopause with d-threo-methyphenidate |
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| EP (1) | EP1411943A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005520780A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20040029360A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002318302B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2453510C (cg-RX-API-DMAC7.html) |
| IL (1) | IL159313A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04000249A (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ565754A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003005962A2 (cg-RX-API-DMAC7.html) |
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| MXPA98000395A (es) | 1995-07-14 | 2005-04-29 | Medeva Europ Ltd | Composicion que comprende d-treo-metilfenidato y otra droga. |
| US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
| US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
| CA2412362A1 (en) * | 2000-06-20 | 2001-12-27 | Arthur L. Heerbst | Cox-2 inhibitors and the prevention of the side effects of radiation therapy |
| FR2823975B1 (fr) * | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| JP4959335B2 (ja) * | 2003-10-08 | 2012-06-20 | マリンクロッド エルエルシー | メチルフェニデート溶液および関連する投与および製造方法 |
| US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
| WO2006012476A2 (en) * | 2004-07-22 | 2006-02-02 | Wyeth | Method for treating nervous system disorders and conditions |
| JP2008507552A (ja) * | 2004-07-22 | 2008-03-13 | ワイス | 神経系障害および状態の治療方法 |
| JP2008507550A (ja) * | 2004-07-22 | 2008-03-13 | ワイス | 神経系障害及び状態の処置方法 |
| US20060100243A1 (en) * | 2004-10-22 | 2006-05-11 | Mark Froimowitz | Methylphenidate analogs and methods of use thereof |
| EP1830648A4 (en) * | 2004-12-09 | 2008-03-12 | Celgene Corp | TREATMENT WITH D-THREO-METHYLPHENIDATE |
| CA2595400C (en) | 2005-01-20 | 2017-01-17 | Institute For Molecular Medicine, Inc. | Methylphenidate derivatives and their use in the treatment of angiogenic diseases and conditions |
| JP5274844B2 (ja) * | 2005-01-20 | 2013-08-28 | インスティチュート フォー モレキュラー メディスン インコーポレイテッド | メチルフェニデート誘導体を含む治療剤 |
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| KR101495146B1 (ko) | 2006-03-16 | 2015-02-24 | 트리스 파마 인코포레이티드 | 약물 - 이온교환 수지 복합체를 함유하는 변형 방출 제제 |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
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| EP2616055A1 (en) * | 2010-09-13 | 2013-07-24 | Tenera Therapeutics, LLC | Compositions for treating cancer treatment - related fatigue |
| US8287903B2 (en) | 2011-02-15 | 2012-10-16 | Tris Pharma Inc | Orally effective methylphenidate extended release powder and aqueous suspension product |
| DK2755498T3 (en) * | 2011-09-15 | 2018-05-22 | Friulchem Spa | COMPOSITION FOR ORAL ADMINISTRATION FOR ANIMALS AND PROCEDURE FOR OBTAINING |
| KR101312286B1 (ko) * | 2012-11-26 | 2013-09-27 | (주)비씨월드제약 | 즉시방출 및 조절방출 특성을 갖고 d-트레오-메틸페니데이트를 포함하는 약학 조성물 |
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| US11590081B1 (en) | 2017-09-24 | 2023-02-28 | Tris Pharma, Inc | Extended release amphetamine tablets |
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-
2001
- 2001-07-12 US US09/903,803 patent/US6486177B2/en not_active Expired - Fee Related
-
2002
- 2002-07-11 CA CA2453510A patent/CA2453510C/en not_active Expired - Fee Related
- 2002-07-11 EP EP02748129A patent/EP1411943A4/en not_active Withdrawn
- 2002-07-11 IL IL15931302A patent/IL159313A0/xx unknown
- 2002-07-11 JP JP2003511771A patent/JP2005520780A/ja active Pending
- 2002-07-11 WO PCT/US2002/022039 patent/WO2003005962A2/en not_active Ceased
- 2002-07-11 MX MXPA04000249A patent/MXPA04000249A/es active IP Right Grant
- 2002-07-11 NZ NZ565754A patent/NZ565754A/en not_active IP Right Cessation
- 2002-07-11 NZ NZ530211A patent/NZ530211A/en not_active IP Right Cessation
- 2002-07-11 KR KR10-2004-7000312A patent/KR20040029360A/ko not_active Ceased
- 2002-07-11 AU AU2002318302A patent/AU2002318302B2/en not_active Ceased
- 2002-07-16 US US10/195,974 patent/US7115631B2/en not_active Expired - Fee Related
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2004
- 2004-04-08 US US10/820,397 patent/US20040204456A1/en not_active Abandoned
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2006
- 2006-04-11 US US11/402,385 patent/US20060183774A1/en not_active Abandoned
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2009
- 2009-12-17 US US12/640,734 patent/US20100093797A1/en not_active Abandoned
-
2011
- 2011-06-30 US US13/172,977 patent/US20110257227A1/en not_active Abandoned
-
2012
- 2012-10-26 US US13/661,472 patent/US20130053414A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ530211A (en) | 2008-04-30 |
| US20020022640A1 (en) | 2002-02-21 |
| US7115631B2 (en) | 2006-10-03 |
| AU2002318302B2 (en) | 2007-03-15 |
| EP1411943A2 (en) | 2004-04-28 |
| IL159313A0 (en) | 2004-06-01 |
| US20040204456A1 (en) | 2004-10-14 |
| KR20040029360A (ko) | 2004-04-06 |
| NZ565754A (en) | 2009-05-31 |
| US20130053414A1 (en) | 2013-02-28 |
| WO2003005962A2 (en) | 2003-01-23 |
| MXPA04000249A (es) | 2004-05-04 |
| EP1411943A4 (en) | 2005-09-28 |
| US20060183774A1 (en) | 2006-08-17 |
| CA2453510A1 (en) | 2003-01-23 |
| US20110257227A1 (en) | 2011-10-20 |
| AU2002318302C1 (en) | 2003-01-29 |
| US20100093797A1 (en) | 2010-04-15 |
| JP2005520780A (ja) | 2005-07-14 |
| US6486177B2 (en) | 2002-11-26 |
| WO2003005962A3 (en) | 2003-06-12 |
| US20020198234A1 (en) | 2002-12-26 |
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