CA2451874C - Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par des cellules endotheliales - Google Patents
Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par des cellules endotheliales Download PDFInfo
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- CA2451874C CA2451874C CA2451874A CA2451874A CA2451874C CA 2451874 C CA2451874 C CA 2451874C CA 2451874 A CA2451874 A CA 2451874A CA 2451874 A CA2451874 A CA 2451874A CA 2451874 C CA2451874 C CA 2451874C
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0107805 | 2001-06-14 | ||
| FR0107805A FR2826010B1 (fr) | 2001-06-14 | 2001-06-14 | Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales |
| PCT/FR2002/002067 WO2002103014A2 (fr) | 2001-06-14 | 2002-06-14 | Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires |
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| CA2451874A1 CA2451874A1 (fr) | 2002-12-27 |
| CA2451874C true CA2451874C (fr) | 2013-07-30 |
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| CA2451874A Expired - Fee Related CA2451874C (fr) | 2001-06-14 | 2002-06-14 | Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par des cellules endotheliales |
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| WO2007031277A2 (en) * | 2005-09-14 | 2007-03-22 | Medizinische Universität Wien | Means and methods for diagnosing endometriosis |
| US8032556B1 (en) * | 2008-03-07 | 2011-10-04 | Symantec Corporation | Systems and methods for user profile data delivery |
| US8470997B2 (en) | 2009-02-05 | 2013-06-25 | Gene Signal International Sa | Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization |
| US8580947B2 (en) | 2009-02-05 | 2013-11-12 | Gene Signal International Sa | Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization |
| EP2418279A1 (en) * | 2010-08-10 | 2012-02-15 | Gene Signal International SA | Injectable pharmaceutical composition for preventing, stabilising and/or inhibiting pathological neovascularization-related conditions |
| US9682144B2 (en) | 2011-06-30 | 2017-06-20 | Gene Signal International, Sa | Composition comprising inhibitors of IRS-1 and of VEGF |
| EP2540828A1 (en) | 2011-06-30 | 2013-01-02 | Gene Signal International SA | Composition comprising inhibitors of IRS-1 and of VEGF |
| CA2840143A1 (en) | 2011-06-30 | 2013-01-03 | Gene Signal International Sa | Composition comprising inhibitors of irs-1 and of vegf |
| US9359604B2 (en) | 2012-07-03 | 2016-06-07 | Gene Signal International Sa | Inhibitor of IRS-1 for treating skin disorders |
| US10052343B1 (en) | 2017-02-03 | 2018-08-21 | Gene Signal International Sa | Sterile formulation comprising a stable phosphorothioate oligonucleotide |
| CN122055446A (zh) * | 2024-06-26 | 2026-05-15 | 思合基因(北京)生物科技有限公司 | 一种靶向IRS-1 mRNA的寡聚核苷酸及其应用 |
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| WO1992013083A1 (en) * | 1991-01-18 | 1992-08-06 | Joslin Diabetes Center, Inc. | Nucleic acid encoding insulin receptor substrate-1 (irs-1), irs-1 protein, diseases, therapy associated with the metabolism of irs-1 |
| FR2733913B1 (fr) * | 1995-05-09 | 1997-08-01 | Sanofi Sa | Sequence d'adn a titre de medicament, et compositions pharmaceutiques en contenant |
| US6498139B1 (en) * | 1997-09-29 | 2002-12-24 | Daiichi Pharmaceutical Co., Ltd. | Remedies for diseases caused by insulin resistance |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
| WO2000070070A1 (en) * | 1999-05-18 | 2000-11-23 | Dnavec Research Inc. | Paramyxoviridae virus vector defective in envelope gene |
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- 2002-06-14 PT PT02751246T patent/PT1409672E/pt unknown
- 2002-06-14 DE DE60232883T patent/DE60232883D1/de not_active Expired - Lifetime
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- 2002-06-14 JP JP2003505336A patent/JP4153421B2/ja not_active Expired - Fee Related
- 2002-06-14 EP EP09164013A patent/EP2166095A3/fr not_active Withdrawn
- 2002-06-14 EP EP02751246A patent/EP1409672B1/fr not_active Expired - Lifetime
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| AU2002345669B9 (en) | 2006-06-29 |
| US8828959B2 (en) | 2014-09-09 |
| EP1409672B1 (fr) | 2009-07-08 |
| US20090082292A1 (en) | 2009-03-26 |
| WO2002103014A3 (fr) | 2004-02-26 |
| JP2004538272A (ja) | 2004-12-24 |
| EP2166095A2 (fr) | 2010-03-24 |
| US7417033B2 (en) | 2008-08-26 |
| FR2826010A1 (fr) | 2002-12-20 |
| ATE435911T1 (de) | 2009-07-15 |
| FR2826010B1 (fr) | 2005-02-25 |
| US20040162257A1 (en) | 2004-08-19 |
| US20080293658A1 (en) | 2008-11-27 |
| AU2002345669B2 (en) | 2006-02-02 |
| DK1409672T3 (da) | 2009-11-09 |
| CY1109464T1 (el) | 2014-08-13 |
| US7855184B2 (en) | 2010-12-21 |
| EP2166095A3 (fr) | 2012-01-04 |
| CA2451874A1 (fr) | 2002-12-27 |
| EP1409672A2 (fr) | 2004-04-21 |
| WO2002103014A2 (fr) | 2002-12-27 |
| DE60232883D1 (de) | 2009-08-20 |
| ES2331835T3 (es) | 2010-01-18 |
| PT1409672E (pt) | 2009-11-04 |
| JP4153421B2 (ja) | 2008-09-24 |
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