FR2826010B1 - Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales - Google Patents

Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales

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Publication number
FR2826010B1
FR2826010B1 FR0107805A FR0107805A FR2826010B1 FR 2826010 B1 FR2826010 B1 FR 2826010B1 FR 0107805 A FR0107805 A FR 0107805A FR 0107805 A FR0107805 A FR 0107805A FR 2826010 B1 FR2826010 B1 FR 2826010B1
Authority
FR
France
Prior art keywords
animals
microm
day
nucleic acid
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0107805A
Other languages
English (en)
French (fr)
Other versions
FR2826010A1 (fr
Inventor
Mahmood Salman Al
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0107805A priority Critical patent/FR2826010B1/fr
Application filed by Individual filed Critical Individual
Priority to CA2451874A priority patent/CA2451874C/fr
Priority to EP02751246A priority patent/EP1409672B1/fr
Priority to PCT/FR2002/002067 priority patent/WO2002103014A2/fr
Priority to JP2003505336A priority patent/JP4153421B2/ja
Priority to DE60232883T priority patent/DE60232883D1/de
Priority to EP09164013A priority patent/EP2166095A3/fr
Priority to AU2002345669A priority patent/AU2002345669B9/en
Priority to DK02751246T priority patent/DK1409672T3/da
Priority to AT02751246T priority patent/ATE435911T1/de
Priority to ES02751246T priority patent/ES2331835T3/es
Priority to PT02751246T priority patent/PT1409672E/pt
Publication of FR2826010A1 publication Critical patent/FR2826010A1/fr
Priority to US10/735,512 priority patent/US7417033B2/en
Application granted granted Critical
Publication of FR2826010B1 publication Critical patent/FR2826010B1/fr
Priority to US11/931,844 priority patent/US7855184B2/en
Priority to US12/050,586 priority patent/US8828959B2/en
Priority to CY20091101035T priority patent/CY1109464T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
FR0107805A 2001-06-14 2001-06-14 Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales Expired - Fee Related FR2826010B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR0107805A FR2826010B1 (fr) 2001-06-14 2001-06-14 Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales
ES02751246T ES2331835T3 (es) 2001-06-14 2002-06-14 Oligonucleotidos antisentido capaces de inhibir la formacion de tubos capilares.
PCT/FR2002/002067 WO2002103014A2 (fr) 2001-06-14 2002-06-14 Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires
JP2003505336A JP4153421B2 (ja) 2001-06-14 2002-06-14 内皮細胞による毛管の形成を阻害し得るアンチセンスオリゴヌクレオチド
DE60232883T DE60232883D1 (de) 2001-06-14 2002-06-14 Antisens-oligonukleotide die fähig sind die herstellung von kapillarröhrchen zu hemmen
EP09164013A EP2166095A3 (fr) 2001-06-14 2002-06-14 Oligonucléotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endothéliales
AU2002345669A AU2002345669B9 (en) 2001-06-14 2002-06-14 Antisense oligonucleotides which can inhibit the formation of capillary tubes by endothelial cells
DK02751246T DK1409672T3 (da) 2001-06-14 2002-06-14 Antisens-oligonukleotider, der kan hæmme dannelsen af kapillarrör
CA2451874A CA2451874C (fr) 2001-06-14 2002-06-14 Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par des cellules endotheliales
EP02751246A EP1409672B1 (fr) 2001-06-14 2002-06-14 Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires
PT02751246T PT1409672E (pt) 2001-06-14 2002-06-14 Oligonucleótideos antisense capazes de inibir a formação de capilares pelas células endoteliais
AT02751246T ATE435911T1 (de) 2001-06-14 2002-06-14 Antisens-oligonukleotide die fähig sind die herstellung von kapillarröhrchen zu hemmen
US10/735,512 US7417033B2 (en) 2001-06-14 2003-12-12 Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells
US11/931,844 US7855184B2 (en) 2001-06-14 2007-10-31 Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells and methods of treating ophthalmic and dermatological diseases
US12/050,586 US8828959B2 (en) 2001-06-14 2008-03-18 Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells
CY20091101035T CY1109464T1 (el) 2001-06-14 2009-10-07 Αντισυνθετικα ολιγονουκλεοτιδια ικανα να αναστειλουν την δημιουργια τριχοειδων σωληνων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0107805A FR2826010B1 (fr) 2001-06-14 2001-06-14 Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales

Publications (2)

Publication Number Publication Date
FR2826010A1 FR2826010A1 (fr) 2002-12-20
FR2826010B1 true FR2826010B1 (fr) 2005-02-25

Family

ID=8864317

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0107805A Expired - Fee Related FR2826010B1 (fr) 2001-06-14 2001-06-14 Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales

Country Status (13)

Country Link
US (3) US7417033B2 (enExample)
EP (2) EP2166095A3 (enExample)
JP (1) JP4153421B2 (enExample)
AT (1) ATE435911T1 (enExample)
AU (1) AU2002345669B9 (enExample)
CA (1) CA2451874C (enExample)
CY (1) CY1109464T1 (enExample)
DE (1) DE60232883D1 (enExample)
DK (1) DK1409672T3 (enExample)
ES (1) ES2331835T3 (enExample)
FR (1) FR2826010B1 (enExample)
PT (1) PT1409672E (enExample)
WO (1) WO2002103014A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007031277A2 (en) * 2005-09-14 2007-03-22 Medizinische Universität Wien Means and methods for diagnosing endometriosis
US8032556B1 (en) * 2008-03-07 2011-10-04 Symantec Corporation Systems and methods for user profile data delivery
US8470997B2 (en) 2009-02-05 2013-06-25 Gene Signal International Sa Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
US8580947B2 (en) 2009-02-05 2013-11-12 Gene Signal International Sa Pharmaceutical composition for preventing, stabilising and/or inhibiting blood and lymph vascularization
EP2418279A1 (en) * 2010-08-10 2012-02-15 Gene Signal International SA Injectable pharmaceutical composition for preventing, stabilising and/or inhibiting pathological neovascularization-related conditions
US9682144B2 (en) 2011-06-30 2017-06-20 Gene Signal International, Sa Composition comprising inhibitors of IRS-1 and of VEGF
EP2540828A1 (en) 2011-06-30 2013-01-02 Gene Signal International SA Composition comprising inhibitors of IRS-1 and of VEGF
CA2840143A1 (en) 2011-06-30 2013-01-03 Gene Signal International Sa Composition comprising inhibitors of irs-1 and of vegf
US9359604B2 (en) 2012-07-03 2016-06-07 Gene Signal International Sa Inhibitor of IRS-1 for treating skin disorders
US10052343B1 (en) 2017-02-03 2018-08-21 Gene Signal International Sa Sterile formulation comprising a stable phosphorothioate oligonucleotide
CN122055446A (zh) * 2024-06-26 2026-05-15 思合基因(北京)生物科技有限公司 一种靶向IRS-1 mRNA的寡聚核苷酸及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013083A1 (en) * 1991-01-18 1992-08-06 Joslin Diabetes Center, Inc. Nucleic acid encoding insulin receptor substrate-1 (irs-1), irs-1 protein, diseases, therapy associated with the metabolism of irs-1
FR2733913B1 (fr) * 1995-05-09 1997-08-01 Sanofi Sa Sequence d'adn a titre de medicament, et compositions pharmaceutiques en contenant
US6498139B1 (en) * 1997-09-29 2002-12-24 Daiichi Pharmaceutical Co., Ltd. Remedies for diseases caused by insulin resistance
US5998148A (en) * 1999-04-08 1999-12-07 Isis Pharmaceuticals Inc. Antisense modulation of microtubule-associated protein 4 expression
WO2000070070A1 (en) * 1999-05-18 2000-11-23 Dnavec Research Inc. Paramyxoviridae virus vector defective in envelope gene

Also Published As

Publication number Publication date
AU2002345669B9 (en) 2006-06-29
US8828959B2 (en) 2014-09-09
EP1409672B1 (fr) 2009-07-08
US20090082292A1 (en) 2009-03-26
WO2002103014A3 (fr) 2004-02-26
JP2004538272A (ja) 2004-12-24
EP2166095A2 (fr) 2010-03-24
US7417033B2 (en) 2008-08-26
FR2826010A1 (fr) 2002-12-20
ATE435911T1 (de) 2009-07-15
US20040162257A1 (en) 2004-08-19
US20080293658A1 (en) 2008-11-27
AU2002345669B2 (en) 2006-02-02
DK1409672T3 (da) 2009-11-09
CY1109464T1 (el) 2014-08-13
US7855184B2 (en) 2010-12-21
EP2166095A3 (fr) 2012-01-04
CA2451874C (fr) 2013-07-30
CA2451874A1 (fr) 2002-12-27
EP1409672A2 (fr) 2004-04-21
WO2002103014A2 (fr) 2002-12-27
DE60232883D1 (de) 2009-08-20
ES2331835T3 (es) 2010-01-18
PT1409672E (pt) 2009-11-04
JP4153421B2 (ja) 2008-09-24

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