CA2447114A1 - Human antipneumococcal antibodies from non-human animals - Google Patents
Human antipneumococcal antibodies from non-human animals Download PDFInfo
- Publication number
- CA2447114A1 CA2447114A1 CA002447114A CA2447114A CA2447114A1 CA 2447114 A1 CA2447114 A1 CA 2447114A1 CA 002447114 A CA002447114 A CA 002447114A CA 2447114 A CA2447114 A CA 2447114A CA 2447114 A1 CA2447114 A1 CA 2447114A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- seq
- acid sequence
- set forth
- dna sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29149201P | 2001-05-16 | 2001-05-16 | |
| US60/291,492 | 2001-05-16 | ||
| PCT/US2002/018363 WO2002092017A2 (en) | 2001-05-16 | 2002-05-16 | Human antipneumococcal antibodies from non-human animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2447114A1 true CA2447114A1 (en) | 2002-11-21 |
Family
ID=23120512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002447114A Abandoned CA2447114A1 (en) | 2001-05-16 | 2002-05-16 | Human antipneumococcal antibodies from non-human animals |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7078492B2 (enExample) |
| EP (1) | EP1463522A4 (enExample) |
| JP (1) | JP2005519580A (enExample) |
| CA (1) | CA2447114A1 (enExample) |
| WO (1) | WO2002092017A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2275128B1 (en) * | 2002-04-02 | 2013-10-16 | Ben Gurion University Of The Negev Research And Development Authority | Protein-based streptococcus pneumoniae vaccines |
| US8691243B2 (en) | 2002-04-02 | 2014-04-08 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based Streptococcus pneumoniae vaccine |
| WO2005003174A1 (en) * | 2003-07-08 | 2005-01-13 | Genesto A/S | BINDING MEMBER TOWARDS PNEUMOCOCCUS SURFACE ADHESIN A PROTEIN (PsaA) |
| EP1791867A2 (en) * | 2004-08-23 | 2007-06-06 | Genesto A/S | Binding member towards pneumolysin |
| US7587238B2 (en) * | 2005-03-11 | 2009-09-08 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
| MX2009008430A (es) | 2007-02-09 | 2009-10-28 | Genentech Inc | Anticuerpos anti-robo4 y sus usos. |
| TWI580694B (zh) | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-vegf抗體 |
| AR077595A1 (es) | 2009-07-27 | 2011-09-07 | Genentech Inc | Tratamientos de combinacion |
| US9321823B2 (en) | 2009-09-02 | 2016-04-26 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| WO2011071577A1 (en) | 2009-12-11 | 2011-06-16 | Genentech, Inc. | Anti-vegf-c antibodies and methods using same |
| CN107095846A (zh) | 2009-12-21 | 2017-08-29 | 霍夫曼-拉罗奇有限公司 | 抗体配制剂 |
| US8481680B2 (en) | 2010-10-05 | 2013-07-09 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| CN104364650B (zh) | 2012-02-01 | 2017-11-21 | 俄克拉荷马医学研究基金会 | 人肺炎链球菌抗体及其用途 |
| RS60534B1 (sr) | 2013-03-13 | 2020-08-31 | Hoffmann La Roche | Formulacije sa smanjenom oksidacijom |
| US20140314778A1 (en) | 2013-03-13 | 2014-10-23 | Genentech, Inc. | Formulations with reduced oxidation |
| US10653779B2 (en) | 2013-03-13 | 2020-05-19 | Genentech, Inc. | Formulations with reduced oxidation |
| NZ711567A (en) | 2013-03-13 | 2020-04-24 | Genentech Inc | Antibody formulations |
| MY174679A (en) | 2013-03-13 | 2020-05-06 | Genentech Inc | Formulations with reduced oxidation |
| AR095348A1 (es) | 2013-03-15 | 2015-10-07 | Genentech Inc | Medios de cultivo celular y métodos de producción de anticuerpos |
| KR20210037745A (ko) | 2013-03-15 | 2021-04-06 | 제넨테크, 인크. | 항산화제를 함유하는 세포 배양 조성물 및 폴리펩티드 생산 방법 |
| PT3049441T (pt) | 2013-09-27 | 2020-01-21 | Hoffmann La Roche | Formulações de anticorpos anti-pdl1 |
| FI3083686T4 (fi) | 2013-12-17 | 2023-05-09 | Menetelmiä syöpien hoitamiseksi käyttäen pd-1-akselia sitovia antagonisteja ja taksaaneja | |
| BR112016013963A2 (pt) | 2013-12-17 | 2017-10-10 | Genentech Inc | terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1 |
| CA2933881A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
| DK3102197T3 (en) | 2014-02-04 | 2018-11-19 | Genentech Inc | Smoothened mutant and methods for its use |
| JP6588461B2 (ja) | 2014-03-31 | 2019-10-09 | ジェネンテック, インコーポレイテッド | 抗血管新生剤及びox40結合アゴニストを含む併用療法 |
| EP3193932B1 (en) | 2014-09-15 | 2023-04-26 | F. Hoffmann-La Roche AG | Antibody formulations |
| EP3221360A1 (en) | 2014-11-17 | 2017-09-27 | F. Hoffmann-La Roche AG | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| CA2975875A1 (en) | 2015-02-04 | 2016-08-11 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| IL256080B2 (en) | 2015-06-17 | 2025-06-01 | Genentech Inc | Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes |
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法(一) |
| AU2016380988B2 (en) | 2015-12-30 | 2022-07-21 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
| US20170239355A1 (en) | 2015-12-30 | 2017-08-24 | Genentech, Inc. | Use of tryptophan derivatives for protein formulations |
| ES2837428T3 (es) | 2016-01-08 | 2021-06-30 | Hoffmann La Roche | Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3 |
| JP2019509721A (ja) | 2016-02-04 | 2019-04-11 | キュリス,インコーポレイテッド | 突然変異体スムースンド及びその使用方法 |
| EP3430054B1 (en) | 2016-03-15 | 2021-12-29 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
| JP7250674B2 (ja) | 2016-08-08 | 2023-04-03 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | がんの治療及び診断方法 |
| AU2019288728A1 (en) | 2018-06-23 | 2021-01-14 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor |
| TW202011991A (zh) | 2018-07-18 | 2020-04-01 | 美商建南德克公司 | 用pd-1軸結合拮抗劑、抗代謝劑及鉑劑治療肺癌之方法 |
| JP7542521B2 (ja) | 2018-08-08 | 2024-08-30 | ジェネンテック, インコーポレイテッド | タンパク質製剤のためのトリプトファン誘導体及びl-メチオニンの使用 |
| ES2955032T3 (es) | 2018-09-21 | 2023-11-28 | Hoffmann La Roche | Métodos de diagnóstico para el cáncer de mama triple negativo |
| CA3181820A1 (en) | 2020-06-16 | 2021-12-23 | Genentech, Inc. | Methods and compositions for treating triple-negative breast cancer |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| DE3668186D1 (de) | 1985-04-01 | 1990-02-15 | Celltech Ltd | Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert. |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| SG48760A1 (en) | 1992-07-24 | 2003-03-18 | Abgenix Inc | Generation of xenogenetic antibodies |
| ATE193301T1 (de) | 1993-03-09 | 2000-06-15 | Genzyme Corp | Verfahren zur isolierung von proteinen aus milch |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6091001A (en) | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| AU705616B2 (en) | 1995-04-21 | 1999-05-27 | Cell Genesys, Inc. | Generation of large genomic DNA deletions |
| DE69637481T2 (de) | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| ES2301183T3 (es) | 1996-12-03 | 2008-06-16 | Amgen Fremont Inc. | Anticuerpo completamente humano que se une al receptor del egfr. |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| WO1999045031A2 (en) | 1998-03-03 | 1999-09-10 | Abgenix, Inc. | Cd147 binding molecules as therapeutics |
| US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
| AU770555B2 (en) | 1998-08-17 | 2004-02-26 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| SG143018A1 (en) | 1998-12-23 | 2008-06-27 | Pfizer | Human monoclonal antibodies to ctla-4 |
-
2002
- 2002-05-16 JP JP2002588936A patent/JP2005519580A/ja not_active Withdrawn
- 2002-05-16 CA CA002447114A patent/CA2447114A1/en not_active Abandoned
- 2002-05-16 EP EP02744269A patent/EP1463522A4/en not_active Withdrawn
- 2002-05-16 WO PCT/US2002/018363 patent/WO2002092017A2/en not_active Ceased
-
2003
- 2003-11-14 US US10/714,079 patent/US7078492B2/en not_active Expired - Fee Related
-
2006
- 2006-05-05 US US11/429,423 patent/US20060258848A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060258848A1 (en) | 2006-11-16 |
| US7078492B2 (en) | 2006-07-18 |
| WO2002092017A2 (en) | 2002-11-21 |
| EP1463522A4 (en) | 2005-04-13 |
| JP2005519580A (ja) | 2005-07-07 |
| EP1463522A1 (en) | 2004-10-06 |
| WO2002092017A8 (en) | 2004-04-22 |
| US20050014931A1 (en) | 2005-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7078492B2 (en) | Human antipneumococcal antibodies from non-human animals | |
| US7777017B2 (en) | Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria | |
| JP2024026132A (ja) | 抗b7-h4抗体、その抗原結合断片及びその医薬用途 | |
| US9089557B2 (en) | Human antibodies against Pseudomonas aeruginosa LPS derived from transgenic xenomouse | |
| JP2011026327A (ja) | グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体 | |
| US20110177087A1 (en) | Human anti-pseudomonas-aeruginosa antibodies derived from transgenic xenomouse | |
| JP2008179634A (ja) | グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 | |
| JP2005514053A6 (ja) | グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 | |
| WO2008095504A1 (en) | A polyclonal antibody product | |
| CN114685653A (zh) | 抗新冠病毒受体结合区域表位中和抗体及其应用 | |
| US20250129142A1 (en) | Antibodies binding to tetanus toxin and uses thereof | |
| WO2004099251A2 (en) | Compositions and methods for treatment of cryptococcosis | |
| AU2002342740A1 (en) | Human antipneumococcal antibodies from non-human animals | |
| JP2008515390A (ja) | ニューモリシンに対する結合メンバー | |
| CN120590524B (zh) | 具有广谱性中和牛病毒性腹泻病毒的单克隆抗体及其应用 | |
| TWI906795B (zh) | 特異性結合Claudin 18.2的抗體及其製法和應用 | |
| TWI795872B (zh) | 抗gm2ap抗體及其應用 | |
| CN1835973A (zh) | 用于治疗隐球菌病的组合物和方法 | |
| MXPA05011989A (en) | Compositions and methods for treatment of cryptococcosis | |
| AU2007216785B2 (en) | Human Antibodies Against Pseudomonas Aeruginosa LPS Derived from Transgenic Xenomouse | |
| AU2012254925B2 (en) | Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |