CA2447045A1 - Method for treatment of tumors using nordihydroguaiaretic acid derivatives - Google Patents
Method for treatment of tumors using nordihydroguaiaretic acid derivatives Download PDFInfo
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- CA2447045A1 CA2447045A1 CA002447045A CA2447045A CA2447045A1 CA 2447045 A1 CA2447045 A1 CA 2447045A1 CA 002447045 A CA002447045 A CA 002447045A CA 2447045 A CA2447045 A CA 2447045A CA 2447045 A1 CA2447045 A1 CA 2447045A1
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- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
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- A61K31/075—Ethers or acetals
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/851,425 | 2001-05-09 | ||
| US09/851,425 US6608108B2 (en) | 1999-10-15 | 2001-05-09 | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
| PCT/US2002/014374 WO2002089795A1 (en) | 2001-05-09 | 2002-05-08 | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2447045A1 true CA2447045A1 (en) | 2002-11-14 |
Family
ID=25310742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002447045A Withdrawn CA2447045A1 (en) | 2001-05-09 | 2002-05-08 | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6608108B2 (enExample) |
| EP (1) | EP1392293B1 (enExample) |
| JP (2) | JP2004534025A (enExample) |
| CN (1) | CN1525857B (enExample) |
| AU (1) | AU2002311890C1 (enExample) |
| CA (1) | CA2447045A1 (enExample) |
| SG (1) | SG169224A1 (enExample) |
| WO (1) | WO2002089795A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6365787B1 (en) * | 1994-09-30 | 2002-04-02 | The Johns Hopkins University | Compounds for the suppression of HIV TAT transactivation |
| US6608108B2 (en) * | 1999-10-15 | 2003-08-19 | Johns Hopkins University | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
| US20060141029A1 (en) * | 2003-05-20 | 2006-06-29 | Erimos Pharmaceuticals Llc | Methods and compositions for delivery of catecholic butanes for treatment of diseases |
| AU2004249124A1 (en) * | 2003-05-20 | 2004-12-29 | Erimos Pharmaceuticals Llc | Methods and compositions for delivery of catecholic butanes for treatment of diseases |
| US7728036B2 (en) | 2003-05-20 | 2010-06-01 | Erimos Pharmaceuticals, Llc | Methods for delivery of catecholic butanes for treatment of tumors |
| JP4579911B2 (ja) * | 2003-06-03 | 2010-11-10 | アイシス・ファーマシューティカルズ・インコーポレイテッド | スルビビン発現の調節 |
| US20060019972A1 (en) * | 2004-04-27 | 2006-01-26 | California Institute Of Technology | Methods of treating cancer by inhibiting histone gene expression |
| CN100440843C (zh) * | 2004-05-12 | 2008-12-03 | 华为技术有限公司 | 一种环网及其业务实现方法 |
| US8440648B2 (en) * | 2004-07-20 | 2013-05-14 | Erimos Pharmaceuticals Llc | Methods and compositions for treatment of intraepithelial neoplasia |
| WO2006069192A1 (en) * | 2004-12-22 | 2006-06-29 | The Gillette Company | Reduction of hair growth with survivin inhibitors |
| EP1845787B1 (en) * | 2005-01-27 | 2015-04-15 | Erimos Pharmaceuticals LLC | Formulations for injection of catecholic butanes, including ndga compounds, into animals |
| CN101150955B (zh) * | 2005-01-27 | 2013-04-17 | 埃里莫斯医药品有限公司 | 递送包括ndga化合物的儿茶酚丁烷的口服制剂 |
| US20060276423A1 (en) * | 2005-04-18 | 2006-12-07 | Rachel Altura | Survivin-directed RNA interference-compositions and methods |
| WO2007038421A2 (en) * | 2005-09-27 | 2007-04-05 | University Of Kentucky Research Foundation | Berry preparations and extracts |
| US8367126B2 (en) | 2005-09-27 | 2013-02-05 | University Of Kentucky Research Foundation | Berry preparations and extracts |
| KR20090006062A (ko) * | 2006-02-23 | 2009-01-14 | 에리모스 파마슈티컬스 엘엘씨 | 인플루엔자 바이러스 감염의 치료 방법 |
| CA2661274A1 (en) * | 2006-08-29 | 2008-03-06 | University Of Kentucky Research Foundation | Compositions and methods for oral cancer chemoprevention using berry preparations and extracts |
| EP2076252B1 (en) * | 2006-10-02 | 2014-04-02 | Erimos Pharmaceuticals LLC | Tetra-substituted ndga derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use |
| US9067875B2 (en) | 2006-10-02 | 2015-06-30 | Erimos Pharmaceuticals Llc | Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use |
| US20100093872A1 (en) * | 2008-10-15 | 2010-04-15 | Erimos Pharmaceuticals Llc | Stable aqueous formulations of water insoluble or poorly soluble drugs |
| CN101690829B (zh) * | 2009-08-31 | 2013-09-18 | 中国科学院上海硅酸盐研究所 | 一种可再细胞化的生物瓣瓣膜材料的制备方法 |
| WO2011030329A1 (en) | 2009-09-10 | 2011-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
| WO2012106556A2 (en) | 2011-02-02 | 2012-08-09 | Amgen Inc. | Methods and compositons relating to inhibition of igf-1r |
| US10342767B2 (en) | 2011-04-21 | 2019-07-09 | Children's Hospital Medical Center | Therapy for kinase-dependent malignancies |
| EP2699237A4 (en) * | 2011-04-21 | 2014-11-12 | Childrens Hosp Medical Center | THERAPY FOR LEUKEMIA |
| WO2013071056A2 (en) | 2011-11-11 | 2013-05-16 | Duke University | Combination drug therapy for the treatment of solid tumors |
| US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| AU2014293013A1 (en) | 2013-07-26 | 2016-03-17 | Race Oncology Ltd. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| CN107708734B (zh) | 2015-06-22 | 2022-01-11 | 詹森生物科技公司 | 用抗cd38抗体和生存素抑制剂联合治疗血红素恶性肿瘤 |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| MX391317B (es) | 2017-02-17 | 2025-03-21 | Promotora Tecnica Ind S A De C V | Composicion mejorada a base de acido norhidroguayaretico. |
| US12171729B2 (en) | 2019-11-25 | 2024-12-24 | The Johns Hopkins University | Formulations of terameprocol and temozolomide and their use in stimulation of humoral immunity in tumors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276060A (en) * | 1979-06-19 | 1994-01-04 | Block/Chemex, G.P. | Methods of treating tumors with compositions of catecholic butanes |
| US5008294A (en) * | 1985-02-11 | 1991-04-16 | Chemex Pharmaceuticals, Inc. | Methods of treating tumors with compositions of catecholic butanes |
| DE3009542A1 (de) | 1980-03-13 | 1981-09-24 | Henkel KGaA, 4000 Düsseldorf | Desodorierende kosmetische zusammensetzungen |
| US4774229A (en) * | 1982-04-05 | 1988-09-27 | Chemex Pharmaceuticals, Inc. | Modification of plant extracts from zygophyllaceae and pharmaceutical use therefor |
| US4708964A (en) * | 1984-02-09 | 1987-11-24 | Chemex Pharmaceuticals | Lipoxygenase inhibitors |
| US4880637A (en) | 1985-02-11 | 1989-11-14 | Chemex Pharmaceuticals, Inc. | Compositions of catecholic butanes with zinc |
| WO1988001509A1 (en) * | 1986-08-25 | 1988-03-10 | Chemex Pharmaceuticals, Inc. | Pharmacologically active compositions of catecholic butanes with zinc |
| US5559149A (en) | 1990-01-29 | 1996-09-24 | Johnson & Johnson Consumer Products, Inc. | Skin care compositions containing retinoids |
| US5646186A (en) | 1994-05-17 | 1997-07-08 | Johnson & Johnson Consumer Products, Inc. | Retinoid composition |
| US5409690A (en) * | 1993-06-23 | 1995-04-25 | Chemex Pharmaceuticals, Inc. | Treatment of multidrug resistant diseases in cancer cell by potentiating with masoprocol |
| US6365787B1 (en) | 1994-09-30 | 2002-04-02 | The Johns Hopkins University | Compounds for the suppression of HIV TAT transactivation |
| US6071949A (en) * | 1995-03-14 | 2000-06-06 | The United States Of America As Represented By The Department Of Health And Human Services | Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents |
| US5837252A (en) | 1996-07-01 | 1998-11-17 | Larreacorp, Ltd. | Nontoxic extract of Larrea tridentata and method of making same |
| US5827898A (en) | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
| DE69739105D1 (de) * | 1996-11-20 | 2008-12-24 | Univ Yale | Survivin, ein protein das zelluläre apoptosis hemmt, und dessen modulation |
| US6077709A (en) * | 1998-09-29 | 2000-06-20 | Isis Pharmaceuticals Inc. | Antisense modulation of Survivin expression |
| US6214874B1 (en) * | 1999-10-15 | 2001-04-10 | John Hopkins University | Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N |
| US6608108B2 (en) * | 1999-10-15 | 2003-08-19 | Johns Hopkins University | Method for treatment of tumors using nordihydroguaiaretic acid derivatives |
-
2001
- 2001-05-09 US US09/851,425 patent/US6608108B2/en not_active Expired - Lifetime
-
2002
- 2002-05-08 CA CA002447045A patent/CA2447045A1/en not_active Withdrawn
- 2002-05-08 WO PCT/US2002/014374 patent/WO2002089795A1/en not_active Ceased
- 2002-05-08 AU AU2002311890A patent/AU2002311890C1/en not_active Ceased
- 2002-05-08 JP JP2002586930A patent/JP2004534025A/ja active Pending
- 2002-05-08 CN CN028138627A patent/CN1525857B/zh not_active Expired - Lifetime
- 2002-05-08 SG SG200507965-2A patent/SG169224A1/en unknown
- 2002-05-08 EP EP02739227.3A patent/EP1392293B1/en not_active Expired - Lifetime
- 2002-10-15 US US10/270,313 patent/US6777444B2/en not_active Expired - Lifetime
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2003
- 2003-12-16 US US10/735,910 patent/US8318815B2/en not_active Expired - Fee Related
-
2009
- 2009-07-29 JP JP2009177106A patent/JP2009242438A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SG169224A1 (en) | 2011-03-30 |
| JP2009242438A (ja) | 2009-10-22 |
| EP1392293B1 (en) | 2016-10-26 |
| JP2004534025A (ja) | 2004-11-11 |
| EP1392293A4 (en) | 2005-05-25 |
| US8318815B2 (en) | 2012-11-27 |
| US6608108B2 (en) | 2003-08-19 |
| WO2002089795A1 (en) | 2002-11-14 |
| US20020065310A1 (en) | 2002-05-30 |
| US6777444B2 (en) | 2004-08-17 |
| US20040127562A1 (en) | 2004-07-01 |
| CN1525857A (zh) | 2004-09-01 |
| AU2002311890C1 (en) | 2008-05-15 |
| CN1525857B (zh) | 2013-06-12 |
| EP1392293A1 (en) | 2004-03-03 |
| AU2002311890B2 (en) | 2007-07-26 |
| US20030171416A1 (en) | 2003-09-11 |
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| EEER | Examination request | ||
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