CA2446738C - Abuse-resistant opioid dosage form - Google Patents
Abuse-resistant opioid dosage form Download PDFInfo
- Publication number
- CA2446738C CA2446738C CA2446738A CA2446738A CA2446738C CA 2446738 C CA2446738 C CA 2446738C CA 2446738 A CA2446738 A CA 2446738A CA 2446738 A CA2446738 A CA 2446738A CA 2446738 C CA2446738 C CA 2446738C
- Authority
- CA
- Canada
- Prior art keywords
- opioid
- antagonist
- tablet
- release
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Air Bags (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2778114A CA2778114A1 (en) | 2001-05-11 | 2002-05-10 | Abuse-resistant opioid dosage form |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29043801P | 2001-05-11 | 2001-05-11 | |
| US60/290,438 | 2001-05-11 | ||
| PCT/US2002/015021 WO2002092059A1 (en) | 2001-05-11 | 2002-05-10 | Abuse-resistant opioid dosage form |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2778114A Division CA2778114A1 (en) | 2001-05-11 | 2002-05-10 | Abuse-resistant opioid dosage form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2446738A1 CA2446738A1 (en) | 2002-11-21 |
| CA2446738C true CA2446738C (en) | 2012-05-29 |
Family
ID=23115998
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2778114A Abandoned CA2778114A1 (en) | 2001-05-11 | 2002-05-10 | Abuse-resistant opioid dosage form |
| CA2446738A Expired - Lifetime CA2446738C (en) | 2001-05-11 | 2002-05-10 | Abuse-resistant opioid dosage form |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2778114A Abandoned CA2778114A1 (en) | 2001-05-11 | 2002-05-10 | Abuse-resistant opioid dosage form |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20030004177A1 (enExample) |
| EP (1) | EP1389092B1 (enExample) |
| JP (3) | JP2005515960A (enExample) |
| CN (2) | CN101439024A (enExample) |
| AT (1) | ATE345112T1 (enExample) |
| AU (1) | AU2002303718B2 (enExample) |
| CA (2) | CA2778114A1 (enExample) |
| DE (1) | DE60216078T2 (enExample) |
| ES (1) | ES2275868T3 (enExample) |
| WO (1) | WO2002092059A1 (enExample) |
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-
2002
- 2002-05-10 JP JP2002588977A patent/JP2005515960A/ja active Pending
- 2002-05-10 CN CNA2008101667341A patent/CN101439024A/zh active Pending
- 2002-05-10 CA CA2778114A patent/CA2778114A1/en not_active Abandoned
- 2002-05-10 AU AU2002303718A patent/AU2002303718B2/en not_active Expired
- 2002-05-10 WO PCT/US2002/015021 patent/WO2002092059A1/en not_active Ceased
- 2002-05-10 CN CNA028097378A patent/CN1592609A/zh active Pending
- 2002-05-10 US US10/143,140 patent/US20030004177A1/en not_active Abandoned
- 2002-05-10 CA CA2446738A patent/CA2446738C/en not_active Expired - Lifetime
- 2002-05-10 ES ES02731767T patent/ES2275868T3/es not_active Expired - Lifetime
- 2002-05-10 AT AT02731767T patent/ATE345112T1/de not_active IP Right Cessation
- 2002-05-10 EP EP02731767A patent/EP1389092B1/en not_active Expired - Lifetime
- 2002-05-10 DE DE60216078T patent/DE60216078T2/de not_active Expired - Lifetime
-
2009
- 2009-03-26 JP JP2009077801A patent/JP2009143964A/ja not_active Withdrawn
-
2010
- 2010-09-30 US US12/894,614 patent/US20110020444A1/en not_active Abandoned
-
2011
- 2011-02-24 US US13/033,899 patent/US20110135731A1/en not_active Abandoned
-
2012
- 2012-05-17 US US13/473,946 patent/US20120231075A1/en not_active Abandoned
- 2012-05-25 US US13/480,737 patent/US20120237603A1/en not_active Abandoned
- 2012-12-19 JP JP2012276500A patent/JP2013053165A/ja active Pending
-
2013
- 2013-02-21 US US13/773,123 patent/US20130209561A1/en not_active Abandoned
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| US20110135731A1 (en) | 2011-06-09 |
| US20130209561A1 (en) | 2013-08-15 |
| ES2275868T3 (es) | 2007-06-16 |
| JP2005515960A (ja) | 2005-06-02 |
| US20110020444A1 (en) | 2011-01-27 |
| JP2009143964A (ja) | 2009-07-02 |
| CN101439024A (zh) | 2009-05-27 |
| CA2446738A1 (en) | 2002-11-21 |
| JP2013053165A (ja) | 2013-03-21 |
| CN1592609A (zh) | 2005-03-09 |
| DE60216078T2 (de) | 2007-07-05 |
| ATE345112T1 (de) | 2006-12-15 |
| CA2778114A1 (en) | 2002-11-21 |
| WO2002092059A1 (en) | 2002-11-21 |
| US20030004177A1 (en) | 2003-01-02 |
| US20120231075A1 (en) | 2012-09-13 |
| US20120237603A1 (en) | 2012-09-20 |
| EP1389092B1 (en) | 2006-11-15 |
| DE60216078D1 (de) | 2006-12-28 |
| EP1389092A1 (en) | 2004-02-18 |
| AU2002303718B2 (en) | 2008-02-28 |
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