CA2441905A1 - Instrument de creation de jeux ordonnes d'echantillons de tissu biologique - Google Patents
Instrument de creation de jeux ordonnes d'echantillons de tissu biologique Download PDFInfo
- Publication number
- CA2441905A1 CA2441905A1 CA002441905A CA2441905A CA2441905A1 CA 2441905 A1 CA2441905 A1 CA 2441905A1 CA 002441905 A CA002441905 A CA 002441905A CA 2441905 A CA2441905 A CA 2441905A CA 2441905 A1 CA2441905 A1 CA 2441905A1
- Authority
- CA
- Canada
- Prior art keywords
- punch
- instrument
- block
- recipient
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000003491 array Methods 0.000 claims abstract description 18
- 230000033001 locomotion Effects 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 5
- 229920001971 elastomer Polymers 0.000 claims 1
- 239000000806 elastomer Substances 0.000 claims 1
- 230000007246 mechanism Effects 0.000 abstract description 18
- 239000002699 waste material Substances 0.000 description 8
- 239000000758 substrate Substances 0.000 description 7
- 238000004080 punching Methods 0.000 description 6
- 230000006872 improvement Effects 0.000 description 5
- 239000001993 wax Substances 0.000 description 5
- 238000012856 packing Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 241000078511 Microtome Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000001744 histochemical effect Effects 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000012332 laboratory investigation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
- G01N2001/2873—Cutting or cleaving
- G01N2001/288—Filter punches
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
- G01N2001/368—Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Stored Programmes (AREA)
- Surgical Instruments (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention concerne des jeux ordonnés de tissu biologique pouvant être créés par suppression de noyaux de régions d'intérêt dans une série de blocs donneurs (16) de tissus incorporés. Les noyaux supprimés sont placés dans un jeu ordonné régulier d'un bloc récepteur (15). Cette opération s'effectue à l'aide de deux poinçons différents, l'un d'eux permettant d'obtenir les noyaux d'intérêt et l'autre permettant de créer des alésages de réception dans le bloc récepteur (15). L'invention concerne également un système comprenant deux axes z séparés, un pour chaque poinçon. Chaque poinçon comprend son propre stylet et l'axe de chacun d'eux est parallèle à son axe d'entraînement. Dans un autre mode de réalisation, l'invention consiste à fournir un seul axe z, un mécanisme permettant de remettre ou de retirer automatiquement aux moins deux poinçons d'un support sur l'axe z.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/811,963 US6383801B1 (en) | 2001-03-19 | 2001-03-19 | Double z-drive tissue array instrument |
| US09/811,963 | 2001-03-19 | ||
| US09/828,829 | 2001-04-09 | ||
| US09/828,829 US6468783B1 (en) | 2001-04-09 | 2001-04-09 | Punch-changing tissue array instrument |
| PCT/US2002/008887 WO2003010280A1 (fr) | 2001-03-19 | 2002-03-19 | Instrument de creation de jeux ordonnes d'echantillons de tissu biologique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2441905A1 true CA2441905A1 (fr) | 2003-02-06 |
Family
ID=27123544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002441905A Abandoned CA2441905A1 (fr) | 2001-03-19 | 2002-03-19 | Instrument de creation de jeux ordonnes d'echantillons de tissu biologique |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP1466967B1 (fr) |
| JP (2) | JP4093182B2 (fr) |
| KR (2) | KR100752820B1 (fr) |
| CN (2) | CN1294251C (fr) |
| AT (2) | ATE310802T1 (fr) |
| CA (1) | CA2441905A1 (fr) |
| CY (2) | CY1104973T1 (fr) |
| DE (2) | DE60207614T2 (fr) |
| DK (2) | DK1466967T3 (fr) |
| ES (2) | ES2252708T3 (fr) |
| NZ (2) | NZ528319A (fr) |
| PT (1) | PT1370639E (fr) |
| SG (1) | SG144710A1 (fr) |
| WO (1) | WO2003010280A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2878859B1 (fr) | 2004-12-02 | 2007-03-23 | Alphelys Sarl | Dispositif de prelevement de carottes pour tissue array |
| DE102005005518A1 (de) * | 2005-02-01 | 2006-08-10 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Einführvorrichtung für biologische Proben |
| DE102007017807A1 (de) | 2006-05-19 | 2008-02-14 | Merz, Hartmut, Prof. Dr. med. | Vorrichtung und Verfahren zur Herstellung von auf Objektträgern angeordneten Proben |
| ATE530664T1 (de) * | 2007-03-07 | 2011-11-15 | Univ Toyama Nat Univ Corp | Verfahren und vorrichtung zur herstellung eines gewebearrayblocks |
| US20110218558A1 (en) | 2008-09-03 | 2011-09-08 | National University Corporation University Of Toyama | Tissue piece forming device and tissue piece forming method |
| ES2321154B1 (es) | 2009-01-19 | 2010-01-25 | Grifols, S.A. | Dispositivo para la extraccion automatica de muestras de liquido de recipientes colectores y procedimiento para realizar dicha extraccion. |
| WO2011052196A1 (fr) * | 2009-10-30 | 2011-05-05 | 株式会社パソロジー研究所 | Dispositif de fabrication de matrices de tissus |
| JP5629939B2 (ja) * | 2010-09-09 | 2014-11-26 | 株式会社パソロジー研究所 | パイルアップ組織アレイ |
| CN102435482B (zh) * | 2011-12-26 | 2013-06-26 | 孙秀会 | 自动点阵定位打片仪 |
| JPWO2014065101A1 (ja) * | 2012-10-24 | 2016-09-08 | オリンパス株式会社 | 基板回収装置 |
| CA2957520C (fr) * | 2014-08-07 | 2022-08-30 | Memorial Sloan-Kettering Cancer Center | Matrice tissulaire utilisant un milieu porteur et procede d'obtention de celle-ci |
| CH710350A2 (de) * | 2014-11-10 | 2016-05-13 | Chemspeed Tech Ag | Dosiervorrichtung. |
| CN109018515B (zh) * | 2018-10-10 | 2020-09-25 | 浙江光跃环保科技股份有限公司 | 一种电子芯片多工位智能传送排放机器人 |
| CN109932534B (zh) * | 2019-03-27 | 2021-03-30 | 昆山福烨电子有限公司 | 一种多用途线性测试仪治具 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2563343B1 (fr) * | 1984-04-19 | 1986-06-13 | Rhone Poulenc Sante | Dispositif pour effectuer des prelevements dans des milieux semi-solides |
| US4979093A (en) * | 1987-07-16 | 1990-12-18 | Cavro Scientific Instruments | XYZ positioner |
| DK1715340T3 (da) * | 1998-02-25 | 2009-01-26 | Us Health | Fremgangsmåde og apparat til forberedelse af vævspröver til parallel analyse |
| US6103518A (en) * | 1999-03-05 | 2000-08-15 | Beecher Instruments | Instrument for constructing tissue arrays |
-
2002
- 2002-03-19 EP EP04001426A patent/EP1466967B1/fr not_active Expired - Lifetime
- 2002-03-19 DK DK04001426T patent/DK1466967T3/da active
- 2002-03-19 DE DE60207614T patent/DE60207614T2/de not_active Expired - Lifetime
- 2002-03-19 KR KR1020067004620A patent/KR100752820B1/ko not_active IP Right Cessation
- 2002-03-19 KR KR1020037012241A patent/KR100786906B1/ko not_active IP Right Cessation
- 2002-03-19 CN CNB2004100351593A patent/CN1294251C/zh not_active Expired - Fee Related
- 2002-03-19 AT AT04001426T patent/ATE310802T1/de not_active IP Right Cessation
- 2002-03-19 NZ NZ528319A patent/NZ528319A/en unknown
- 2002-03-19 DE DE60224016T patent/DE60224016T2/de not_active Expired - Lifetime
- 2002-03-19 EP EP07023975A patent/EP1930405A1/fr not_active Withdrawn
- 2002-03-19 PT PT02790228T patent/PT1370639E/pt unknown
- 2002-03-19 AT AT02790228T patent/ATE380860T1/de not_active IP Right Cessation
- 2002-03-19 DK DK02790228T patent/DK1370639T3/da active
- 2002-03-19 ES ES04001426T patent/ES2252708T3/es not_active Expired - Lifetime
- 2002-03-19 CA CA002441905A patent/CA2441905A1/fr not_active Abandoned
- 2002-03-19 WO PCT/US2002/008887 patent/WO2003010280A1/fr active IP Right Grant
- 2002-03-19 NZ NZ533143A patent/NZ533143A/en unknown
- 2002-03-19 ES ES02790228T patent/ES2298409T3/es not_active Expired - Lifetime
- 2002-03-19 CN CNB028068246A patent/CN100413955C/zh not_active Expired - Fee Related
- 2002-03-19 SG SG200401901-4A patent/SG144710A1/en unknown
- 2002-03-19 JP JP2003515631A patent/JP4093182B2/ja not_active Expired - Fee Related
- 2002-03-19 EP EP02790228A patent/EP1370639B1/fr not_active Expired - Lifetime
-
2004
- 2004-01-16 JP JP2004009502A patent/JP3991989B2/ja not_active Expired - Fee Related
-
2006
- 2006-02-13 CY CY20061100200T patent/CY1104973T1/el unknown
-
2008
- 2008-03-07 CY CY20081100259T patent/CY1109893T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6383801B1 (en) | Double z-drive tissue array instrument | |
| US6468783B1 (en) | Punch-changing tissue array instrument | |
| EP1466967B1 (fr) | Instrument de création de jeux ordonnés d'echantillons de tissu biologique | |
| EP1161520B1 (fr) | Instrument pour creer des structures de tissus | |
| US20060243110A1 (en) | Apparatus for removing a sample from an array of samples and a cutting tool for use with that apparatus | |
| US20040197897A1 (en) | Tissue array instrument | |
| JP4316139B2 (ja) | ポリマー支持材料から試料を採取する装置及び方法 | |
| AU2002306816B2 (en) | Tissue array instrument | |
| AU2002306816A1 (en) | Tissue array instrument | |
| EP1017982A1 (fr) | Dispositif permettant de sortir un echantillon d'un ensemble d'echantillons et outil coupant pour ledit dispositif |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |