CA2439258C - Suppressed chromatography and salt conversion system - Google Patents
Suppressed chromatography and salt conversion system Download PDFInfo
- Publication number
- CA2439258C CA2439258C CA2439258A CA2439258A CA2439258C CA 2439258 C CA2439258 C CA 2439258C CA 2439258 A CA2439258 A CA 2439258A CA 2439258 A CA2439258 A CA 2439258A CA 2439258 C CA2439258 C CA 2439258C
- Authority
- CA
- Canada
- Prior art keywords
- salt
- analyte
- suppressor
- flow channel
- convertor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000003839 salts Chemical class 0.000 title claims abstract description 186
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 81
- 238000004587 chromatography analysis Methods 0.000 title description 24
- 239000012491 analyte Substances 0.000 claims abstract description 145
- 150000002500 ions Chemical class 0.000 claims abstract description 136
- 239000003792 electrolyte Substances 0.000 claims abstract description 78
- 239000002253 acid Substances 0.000 claims abstract description 60
- 239000012528 membrane Substances 0.000 claims abstract description 52
- 230000001629 suppression Effects 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 38
- 239000003480 eluent Substances 0.000 claims abstract description 34
- 150000001450 anions Chemical class 0.000 claims abstract description 28
- 238000004458 analytical method Methods 0.000 claims abstract description 20
- 238000005342 ion exchange Methods 0.000 claims abstract description 20
- 239000012488 sample solution Substances 0.000 claims abstract description 7
- 239000012492 regenerant Substances 0.000 claims description 78
- 239000000523 sample Substances 0.000 claims description 39
- 239000003014 ion exchange membrane Substances 0.000 claims description 32
- 150000001768 cations Chemical class 0.000 claims description 29
- 238000001514 detection method Methods 0.000 claims description 11
- 230000001172 regenerating effect Effects 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract description 16
- 239000011734 sodium Substances 0.000 abstract description 16
- 229910052708 sodium Inorganic materials 0.000 abstract description 15
- 150000007513 acids Chemical class 0.000 abstract description 4
- 239000002585 base Substances 0.000 description 41
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 30
- 230000004044 response Effects 0.000 description 22
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 12
- 238000011144 upstream manufacturing Methods 0.000 description 11
- 239000002699 waste material Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- -1 hydronium ions Chemical class 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-O oxonium Chemical compound [OH3+] XLYOFNOQVPJJNP-UHFFFAOYSA-O 0.000 description 8
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 7
- 239000003456 ion exchange resin Substances 0.000 description 7
- 229920003303 ion-exchange polymer Polymers 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 7
- 229910021529 ammonia Inorganic materials 0.000 description 6
- 238000004255 ion exchange chromatography Methods 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 5
- 230000008929 regeneration Effects 0.000 description 5
- 238000011069 regeneration method Methods 0.000 description 5
- 229910001415 sodium ion Inorganic materials 0.000 description 5
- 238000013375 chromatographic separation Methods 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000001724 coherent Stokes Raman spectroscopy Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 229910052744 lithium Inorganic materials 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000008384 membrane barrier Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
- 239000008364 bulk solution Substances 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 238000005277 cation exchange chromatography Methods 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000019990 fruit wine Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
- G01N2030/965—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange suppressor columns
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/797,914 | 2001-03-01 | ||
| US09/797,914 US6752927B2 (en) | 2001-03-01 | 2001-03-01 | Suppressed chromatography and salt conversion system |
| PCT/US2002/006227 WO2002071052A2 (en) | 2001-03-01 | 2002-02-28 | Suppressed chromatography and salt conversion system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2439258A1 CA2439258A1 (en) | 2002-09-12 |
| CA2439258C true CA2439258C (en) | 2010-06-01 |
Family
ID=25172084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2439258A Expired - Fee Related CA2439258C (en) | 2001-03-01 | 2002-02-28 | Suppressed chromatography and salt conversion system |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6752927B2 (enExample) |
| EP (1) | EP1373882B1 (enExample) |
| JP (1) | JP4122228B2 (enExample) |
| AU (1) | AU2002247237B2 (enExample) |
| CA (1) | CA2439258C (enExample) |
| WO (1) | WO2002071052A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6752927B2 (en) * | 2001-03-01 | 2004-06-22 | Dionex Corporation | Suppressed chromatography and salt conversion system |
| US7128823B2 (en) | 2002-07-24 | 2006-10-31 | Applied Materials, Inc. | Anolyte for copper plating |
| WO2006023985A2 (en) * | 2004-08-23 | 2006-03-02 | Remote Clinical Solutions, Inc. | System and method for modifying a fluid for oral administration |
| EP2747880B1 (en) | 2011-08-23 | 2021-03-24 | Board Of Regents, The University Of Texas System | Electrolytic buffer generator |
| US10048233B2 (en) | 2012-11-12 | 2018-08-14 | Dionex Corporation | Suppressor device |
| US9964510B2 (en) | 2013-09-16 | 2018-05-08 | Dionex Corporation | Electrolytic four-channel device and method |
| US9625430B2 (en) | 2013-10-18 | 2017-04-18 | Dionex Corporation | Multielectrode electrolytic device and method |
| US11090606B2 (en) | 2013-12-05 | 2021-08-17 | Dionex Corporation | Gas-less electrolytic device and method |
| US20170051344A1 (en) | 2014-01-24 | 2017-02-23 | Life Technologies Corporation | Purification Chemistries and Formats for Sanger DNA Sequencing Reactions on a Micro-Fluidics Device |
| JP6379594B2 (ja) * | 2014-03-31 | 2018-08-29 | 東ソー株式会社 | イオン化合物のイオン変換方法及びイオン変換装置 |
| JP6379593B2 (ja) * | 2014-03-31 | 2018-08-29 | 東ソー株式会社 | イオン化合物のイオン変換方法およびイオン変換装置 |
| US9931585B2 (en) | 2014-04-23 | 2018-04-03 | Dionex Corporation | Electrolytic device for contaminant removal and method |
| US20160137530A1 (en) * | 2014-11-13 | 2016-05-19 | Dionex Corporation | Ion exchange based volatile component removal device for ion chromatography |
| JP6631132B2 (ja) * | 2015-09-30 | 2020-01-15 | 東ソー株式会社 | イオン化合物のイオン変換方法及びイオン変換装置 |
| JP6631131B2 (ja) * | 2015-09-30 | 2020-01-15 | 東ソー株式会社 | イオン化合物のイオン変換方法及びイオン変換装置 |
| JP6578863B2 (ja) * | 2015-09-30 | 2019-09-25 | 東ソー株式会社 | イオン化合物のイオン変換方法及びイオン変換装置 |
| JP6597138B2 (ja) * | 2015-09-30 | 2019-10-30 | 東ソー株式会社 | イオン化合物のイオン変換方法及びイオン変換装置 |
| US11287403B2 (en) | 2016-01-07 | 2022-03-29 | Board Of Regents, The University Of Texas System | Ion chromatography system and methods utilizing a weak acid or weak base extraction device |
| US10948466B2 (en) * | 2017-03-03 | 2021-03-16 | Dionex Corporation | Flow control in an electrolytic reagent concentrator for ion chromatography |
| US12306153B2 (en) * | 2019-03-27 | 2025-05-20 | Shimadzu Corporation | Ion chromatograph |
| CN113631919B (zh) | 2019-04-01 | 2023-12-29 | 株式会社岛津制作所 | 离子色谱仪及离子成分分析方法 |
| CN111214848B (zh) * | 2020-01-20 | 2020-11-20 | 青岛盛瀚色谱技术有限公司 | 一种离子色谱抑制器 |
| CN112782335A (zh) * | 2020-12-29 | 2021-05-11 | 中国水产科学研究院黄海水产研究所 | 一种采用离子色谱同步检测大气中mma+、dma+、tma+和dea+的方法 |
| US20230184728A1 (en) * | 2021-12-09 | 2023-06-15 | Dionex Corporation | Suppressor |
| US11860143B2 (en) * | 2021-12-21 | 2024-01-02 | Dionex Corporation | Method and system for self-regulating a suppressor |
| US20240159721A1 (en) * | 2022-11-14 | 2024-05-16 | Dionex Corporation | Chromatography Baseline Stability |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3925019A (en) | 1973-08-06 | 1975-12-09 | Dow Chemical Co | Chromatographic analysis of ionic species |
| US3926559A (en) | 1973-08-06 | 1975-12-16 | Dow Chemical Co | Method and apparatus for quantitative chromatographic analysis of cationic species |
| US3920397A (en) | 1973-08-06 | 1975-11-18 | Dow Chemical Co | Apparatus and method for quantitative analysis of ionic species by liquid column chromatography |
| US3897213A (en) | 1973-08-06 | 1975-07-29 | Dow Chemical Co | Automated quantitative analysis of ionic species |
| US4474664A (en) | 1980-01-16 | 1984-10-02 | The Dow Chemical Company | Ion analysis method and apparatus |
| US4265634A (en) | 1980-03-10 | 1981-05-05 | Dionex Corporation | Chromatographic separation and quantitative analysis of ionic species |
| US4751004A (en) | 1981-09-18 | 1988-06-14 | The Dow Chemical Company | Liquid chromatographic method and apparatus with a packed tube membrane device for post-column derivatization/suppression reactions |
| US4455233A (en) | 1983-08-12 | 1984-06-19 | Dionex Corporation | Method and apparatus for ion analysis and detection using reverse mode suppression |
| US4999098A (en) | 1984-10-04 | 1991-03-12 | Dionex Corporation | Modified membrane suppressor and method for use |
| US4861555A (en) | 1985-03-11 | 1989-08-29 | Applied Automation, Inc. | Apparatus for chromatographic analysis of ionic species |
| JPS6270757A (ja) | 1985-09-25 | 1987-04-01 | Toyo Soda Mfg Co Ltd | 液体クロマトグラフイ−による分離・分析方法及び分離・分析装置 |
| US4751189A (en) | 1986-03-11 | 1988-06-14 | Dionex Corporation | Method for balancing background conductivity for ion chromatography |
| US5045204A (en) | 1990-02-13 | 1991-09-03 | Dionex Corporation | Method and apparatus for generating a high purity chromatography eluent |
| US5068090A (en) | 1990-03-26 | 1991-11-26 | The Babcock & Wilcox Company | Aqueous carbon dioxide monitor |
| US5248426A (en) | 1992-02-10 | 1993-09-28 | Dionex Corporation | Ion chromatography system using electrochemical suppression and detector effluent recycle |
| JPH07505960A (ja) * | 1993-02-02 | 1995-06-29 | ダイオネックス コーポレイション | 連続イオンクロマトグラフィーおよび変換装置 |
| WO1995006246A1 (en) | 1993-08-27 | 1995-03-02 | Dionex Corporation | Ion chromatography using frequent regeneration of batch-type suppressor |
| JPH09511838A (ja) * | 1995-03-03 | 1997-11-25 | オールテック アソシエイツ インコーポレイテッド | クロマトグラフィー物質を電気化学的に改良するための装置／方法 |
| US5633171A (en) | 1995-03-03 | 1997-05-27 | Dionex Corporation | Intermittent electrolytic packed bed suppressor regeneration for ion chromatography |
| US6325976B1 (en) | 1998-02-26 | 2001-12-04 | Dionex Corporation | Continuous electrolytically regenerated packed bed suppressor for ion chromatography |
| US6077434A (en) | 1999-01-15 | 2000-06-20 | Dionex Corporation | Current-efficient suppressors and method of use |
| US6468804B1 (en) | 1999-08-02 | 2002-10-22 | Alltech Associates, Inc. | Suppressor for continuous electrochemically suppressed ion chromatography and method |
| US6436719B1 (en) | 2000-03-08 | 2002-08-20 | Dionex Corporation | Displacement chemical regeneration method and apparatus |
| US6752927B2 (en) * | 2001-03-01 | 2004-06-22 | Dionex Corporation | Suppressed chromatography and salt conversion system |
| US6808608B2 (en) * | 2002-03-13 | 2004-10-26 | Dionex Corporation | Water purifier and method |
| US7517696B2 (en) * | 2003-01-30 | 2009-04-14 | Dionex Corporation | Chemical suppressors and method of use |
| US7473354B2 (en) * | 2005-09-16 | 2009-01-06 | Dionex Corporation | Recycled suppressor regenerants |
-
2001
- 2001-03-01 US US09/797,914 patent/US6752927B2/en not_active Expired - Lifetime
-
2002
- 2002-02-28 JP JP2002569923A patent/JP4122228B2/ja not_active Expired - Fee Related
- 2002-02-28 CA CA2439258A patent/CA2439258C/en not_active Expired - Fee Related
- 2002-02-28 EP EP02715016.8A patent/EP1373882B1/en not_active Expired - Lifetime
- 2002-02-28 WO PCT/US2002/006227 patent/WO2002071052A2/en not_active Ceased
- 2002-02-28 AU AU2002247237A patent/AU2002247237B2/en not_active Ceased
-
2004
- 2004-04-27 US US10/833,458 patent/US7618535B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004522970A (ja) | 2004-07-29 |
| WO2002071052A2 (en) | 2002-09-12 |
| WO2002071052A3 (en) | 2003-02-27 |
| US6752927B2 (en) | 2004-06-22 |
| EP1373882A2 (en) | 2004-01-02 |
| CA2439258A1 (en) | 2002-09-12 |
| US7618535B2 (en) | 2009-11-17 |
| AU2002247237B2 (en) | 2007-02-08 |
| US20040195100A1 (en) | 2004-10-07 |
| EP1373882B1 (en) | 2015-09-02 |
| US20020162804A1 (en) | 2002-11-07 |
| JP4122228B2 (ja) | 2008-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180228 |