CA2438509C - Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria - Google Patents

Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria Download PDF

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Publication number
CA2438509C
CA2438509C CA2438509A CA2438509A CA2438509C CA 2438509 C CA2438509 C CA 2438509C CA 2438509 A CA2438509 A CA 2438509A CA 2438509 A CA2438509 A CA 2438509A CA 2438509 C CA2438509 C CA 2438509C
Authority
CA
Canada
Prior art keywords
dysuria
compound
group
methyl
cyclohexenone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2438509A
Other languages
English (en)
French (fr)
Other versions
CA2438509A1 (en
Inventor
Masao Miyagawa
Takeshi Watanabe
Motoaki Saito
Bang Luu
Masashi Yamada
Hiroto Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
Meiji Co Ltd
Original Assignee
Meiji Dairies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Dairies Corp filed Critical Meiji Dairies Corp
Publication of CA2438509A1 publication Critical patent/CA2438509A1/en
Application granted granted Critical
Publication of CA2438509C publication Critical patent/CA2438509C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2438509A 2001-02-19 2002-02-15 Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria Expired - Lifetime CA2438509C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001041587A JP3836684B2 (ja) 2001-02-19 2001-02-19 排尿障害治療剤
JP2001-041587 2001-02-19
PCT/JP2002/001292 WO2002066024A1 (en) 2001-02-19 2002-02-15 Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria

Publications (2)

Publication Number Publication Date
CA2438509A1 CA2438509A1 (en) 2002-08-29
CA2438509C true CA2438509C (en) 2010-04-20

Family

ID=18904009

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2438509A Expired - Lifetime CA2438509C (en) 2001-02-19 2002-02-15 Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria

Country Status (7)

Country Link
US (1) US6906107B2 (enExample)
EP (1) EP1368014B1 (enExample)
JP (1) JP3836684B2 (enExample)
AT (1) ATE345787T1 (enExample)
CA (1) CA2438509C (enExample)
DE (1) DE60216239T8 (enExample)
WO (1) WO2002066024A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4861560B2 (ja) * 2001-02-19 2012-01-25 株式会社明治 糖尿病合併症治療剤
CA2519178C (en) * 2003-03-28 2010-01-12 Meiji Dairies Corporation Process for producing cyclohexenone long-chain alcohols
CN101065119B (zh) * 2004-11-25 2010-08-25 明治乳业株式会社 肾功能不全的改良剂
CN101180041B (zh) * 2005-01-18 2011-04-13 明治乳业株式会社 感觉障碍治疗剂
US20080312336A1 (en) * 2005-05-26 2008-12-18 Keisuke Satoh Preventive and/or Therapeutic Agent for Diabetic Vascular Disorder and Respiratory Disorder
WO2013147072A1 (ja) * 2012-03-29 2013-10-03 大鵬薬品工業株式会社 3-(15-ヒドロキシペンタデシル)-2,4,4-トリメチル-2-シクロヘキセン-1-オンの共結晶
JP5566521B1 (ja) * 2013-09-27 2014-08-06 大鵬薬品工業株式会社 膀胱・尿道協調不全改善剤
US20170035705A1 (en) * 2015-08-04 2017-02-09 Taiho Pharmaceutical Co., Ltd. Detrusor hyperactivity with impaired contractility ameliorating agent
JP6894555B1 (ja) * 2020-07-03 2021-06-30 大鵬薬品工業株式会社 排尿症状治療剤
JP2022013721A (ja) * 2020-07-03 2022-01-18 大鵬薬品工業株式会社 排尿症状治療剤
US20230295068A1 (en) * 2020-08-07 2023-09-21 Taiho Pharmaceutical Co., Ltd. Novel cycloalkenone compound or salt thereof
US20250178998A1 (en) 2022-02-09 2025-06-05 Taiho Pharmaceutical Co., Ltd. Crystal form of cyclohexenone compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113947A (en) 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
DE69811905T2 (de) * 1997-08-13 2003-11-06 Meiji Milk Products Co. Ltd., Tokio/Tokyo Cyclohexenon langketten alkohol und diese enthaltendes arzneimittel

Also Published As

Publication number Publication date
JP3836684B2 (ja) 2006-10-25
US6906107B2 (en) 2005-06-14
EP1368014A1 (en) 2003-12-10
DE60216239T8 (de) 2007-06-21
US20040132829A1 (en) 2004-07-08
WO2002066024A1 (en) 2002-08-29
CA2438509A1 (en) 2002-08-29
ATE345787T1 (de) 2006-12-15
JP2002241271A (ja) 2002-08-28
DE60216239T2 (de) 2007-03-08
DE60216239D1 (de) 2007-01-04
EP1368014B1 (en) 2006-11-22

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Effective date: 20220215