CA2435611C - Alpha-amino-n-hydroxy-acetamide derivatives - Google Patents
Alpha-amino-n-hydroxy-acetamide derivatives Download PDFInfo
- Publication number
- CA2435611C CA2435611C CA2435611A CA2435611A CA2435611C CA 2435611 C CA2435611 C CA 2435611C CA 2435611 A CA2435611 A CA 2435611A CA 2435611 A CA2435611 A CA 2435611A CA 2435611 C CA2435611 C CA 2435611C
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- Canada
- Prior art keywords
- formula
- compound
- triazol
- salt
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0103303.4A GB0103303D0 (en) | 2001-02-09 | 2001-02-09 | Organic compounds |
| GB0103303.4 | 2001-02-09 | ||
| PCT/EP2002/001345 WO2002064552A1 (en) | 2001-02-09 | 2002-02-08 | 1g(a)-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2435611A1 CA2435611A1 (en) | 2002-08-22 |
| CA2435611C true CA2435611C (en) | 2011-07-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2435611A Expired - Fee Related CA2435611C (en) | 2001-02-09 | 2002-02-08 | Alpha-amino-n-hydroxy-acetamide derivatives |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7112611B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1360175A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4262982B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN100509773C (cg-RX-API-DMAC10.html) |
| AR (1) | AR032553A1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2002249197A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2435611C (cg-RX-API-DMAC10.html) |
| GB (1) | GB0103303D0 (cg-RX-API-DMAC10.html) |
| PE (1) | PE20020845A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2002064552A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| GB0103303D0 (en) * | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
| WO2005090297A1 (en) * | 2004-03-19 | 2005-09-29 | Biotie Therapies Corporation | Sulphonamide derivatives |
| US8232427B2 (en) * | 2006-03-29 | 2012-07-31 | Novartis Ag | Selective hydroxamate based MMP inhibitors |
| US20100234378A1 (en) * | 2006-08-22 | 2010-09-16 | Array Biopharma Inc. | Alkylsulfonamide-substituted triazoles as matrix metalloprotease inhibitors |
| WO2008147764A1 (en) * | 2007-05-23 | 2008-12-04 | Array Biopharma, Inc. | Mmp inhibitors and methods of use thereof |
| CA2896053A1 (en) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| US11058804B2 (en) | 2017-06-13 | 2021-07-13 | Ethicon Llc | Surgical fastener device for the prevention of ECM degradation |
| US20180353175A1 (en) * | 2017-06-13 | 2018-12-13 | Ethicon Llc | Surgical Fastener with Broad Spectrum MMP Inhibitors |
| CN110740764B (zh) * | 2017-06-13 | 2022-05-27 | 爱惜康有限责任公司 | 具有广谱mmp抑制剂的外科紧固件 |
| CN110769866B (zh) * | 2017-06-13 | 2022-07-29 | 爱惜康有限责任公司 | 具有可控愈合的外科缝合器 |
| US10939911B2 (en) | 2017-06-13 | 2021-03-09 | Ethicon Llc | Surgical stapler with end effector coating |
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| US2513826A (en) | 1946-12-05 | 1950-07-04 | Gen Aniline & Film Corp | Aromatic sulfonhydrazides |
| US4772733A (en) | 1986-07-17 | 1988-09-20 | Hercules Incorporated | Epoxy-azides |
| US4806528A (en) | 1987-09-04 | 1989-02-21 | Hanreich Reinhard G | Process for the preparation of 2-(2-chloroethoxy)-benzenesulfonamide |
| US5338755A (en) | 1990-07-31 | 1994-08-16 | Elf Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
| FR2682498A1 (fr) | 1991-10-15 | 1993-04-16 | Kodak Pathe | Colorants comprenant des macrocycles thioethers. |
| US5663431A (en) | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| US5506242A (en) | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| GB9503749D0 (en) | 1995-02-24 | 1995-04-12 | British Biotech Pharm | Synthesis of hydroxamic acid derivatives |
| CA2242416C (en) * | 1996-01-23 | 2006-03-21 | Shionogi & Co., Ltd. | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
| NZ325939A (en) * | 1996-01-23 | 2000-06-23 | Shionogi & Co | Sulphonated amino acid derivatives and matrix metalloproteinase inhibitors (MMP) containing these derivatives |
| CZ294063B6 (cs) | 1996-05-17 | 2004-09-15 | Warner-Lambert Company | Bifenylsulfonamid, jeho použití a farmaceutický prostředek s jeho obsahem |
| JPH10265452A (ja) | 1996-05-24 | 1998-10-06 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
| WO1998018754A1 (en) | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
| MXPA99001974A (es) | 1996-12-09 | 2002-03-27 | Warner Lambert Co | Metodo para tratar y prevenir fallas cardiacas y dilatacion ventricular. |
| HUP0000852A2 (hu) | 1997-02-03 | 2001-05-28 | Pfizer Products Inc. | Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények |
| GB9708133D0 (en) | 1997-04-22 | 1997-06-11 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| DE19719621A1 (de) | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| ATE210639T1 (de) | 1997-05-09 | 2001-12-15 | Hoechst Ag | Substituierte diaminocarbonsäuren |
| CN1265647A (zh) | 1997-07-31 | 2000-09-06 | 普罗克特和甘保尔公司 | 无环金属蛋白酶抑制剂 |
| IL127496A0 (en) | 1997-12-19 | 1999-10-28 | Pfizer Prod Inc | The use of MMP inhibitors for the treatment of ocular angiogenesis |
| PL342009A1 (en) | 1998-02-04 | 2001-05-07 | Novartis Ag | Sulphonylamine derivatives capable to inhibit extracellular substance degrading metaloproteinases |
| JPH11236369A (ja) * | 1998-02-23 | 1999-08-31 | Kotobuki Seiyaku Kk | スルホンアミド誘導体及びその製造法並びにこれを含有する医薬組成物 |
| PA8469301A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Procedimientos para la preparacion de acidos hidroxamicos. |
| CZ20012294A3 (cs) | 1998-12-22 | 2001-12-12 | F. Hoffmann-La Roche Ag | Sulfonamidové hydroxamáty |
| AR035311A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento |
| AR035313A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos. |
| GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| GB0103303D0 (en) * | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
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2001
- 2001-02-09 GB GBGB0103303.4A patent/GB0103303D0/en not_active Ceased
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2002
- 2002-02-07 AR ARP020100398A patent/AR032553A1/es unknown
- 2002-02-07 PE PE2002000088A patent/PE20020845A1/es not_active Application Discontinuation
- 2002-02-08 CA CA2435611A patent/CA2435611C/en not_active Expired - Fee Related
- 2002-02-08 EP EP02718115A patent/EP1360175A1/en not_active Withdrawn
- 2002-02-08 US US10/467,611 patent/US7112611B2/en not_active Expired - Fee Related
- 2002-02-08 AU AU2002249197A patent/AU2002249197A1/en not_active Abandoned
- 2002-02-08 WO PCT/EP2002/001345 patent/WO2002064552A1/en not_active Ceased
- 2002-02-08 CN CNB028047133A patent/CN100509773C/zh not_active Expired - Fee Related
- 2002-02-08 JP JP2002564485A patent/JP4262982B2/ja not_active Expired - Fee Related
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2006
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2007
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2002249197A1 (en) | 2002-08-28 |
| PE20020845A1 (es) | 2002-10-30 |
| US7659293B2 (en) | 2010-02-09 |
| US20080176916A1 (en) | 2008-07-24 |
| JP4262982B2 (ja) | 2009-05-13 |
| WO2002064552A1 (en) | 2002-08-22 |
| US7291634B2 (en) | 2007-11-06 |
| US20040082630A1 (en) | 2004-04-29 |
| WO2002064552A8 (en) | 2002-12-12 |
| JP2004523545A (ja) | 2004-08-05 |
| AR032553A1 (es) | 2003-11-12 |
| CN100509773C (zh) | 2009-07-08 |
| EP1360175A1 (en) | 2003-11-12 |
| CA2435611A1 (en) | 2002-08-22 |
| GB0103303D0 (en) | 2001-03-28 |
| CN1525956A (zh) | 2004-09-01 |
| US20060270719A1 (en) | 2006-11-30 |
| US7112611B2 (en) | 2006-09-26 |
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