CA2434831C - Polypeptide drug substances - Google Patents
Polypeptide drug substances Download PDFInfo
- Publication number
- CA2434831C CA2434831C CA2434831A CA2434831A CA2434831C CA 2434831 C CA2434831 C CA 2434831C CA 2434831 A CA2434831 A CA 2434831A CA 2434831 A CA2434831 A CA 2434831A CA 2434831 C CA2434831 C CA 2434831C
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- species
- pharmaceutical agent
- composition
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26233701P | 2001-01-17 | 2001-01-17 | |
US60/262,337 | 2001-01-17 | ||
US28788601P | 2001-05-01 | 2001-05-01 | |
US25787201P | 2001-05-01 | 2001-05-01 | |
US60/257,872 | 2001-05-01 | ||
US60/287,886 | 2001-05-01 | ||
US33263601P | 2001-11-06 | 2001-11-06 | |
US60/332,636 | 2001-11-06 | ||
PCT/IB2002/000133 WO2002056916A2 (en) | 2001-01-17 | 2002-01-17 | Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2434831A1 CA2434831A1 (en) | 2002-07-25 |
CA2434831C true CA2434831C (en) | 2012-03-06 |
Family
ID=27500604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2434831A Expired - Lifetime CA2434831C (en) | 2001-01-17 | 2002-01-17 | Polypeptide drug substances |
Country Status (4)
Country | Link |
---|---|
JP (2) | JP5057628B2 (ja) |
CN (2) | CN1545422B (ja) |
AU (1) | AU2002228260B2 (ja) |
CA (1) | CA2434831C (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180110187A (ko) * | 2009-05-08 | 2018-10-08 | 테크필즈 바이오켐 코., 엘티디. | 펩티드 및 펩티드관련 화합물의 고침투성 전구약물 조성물 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4396606A (en) * | 1979-11-05 | 1983-08-02 | Addiction Research Foundation | Novel polypeptide analgesics |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
ES2245003T3 (es) * | 1996-08-27 | 2005-12-16 | Praecis Pharmaceuticals Incorporated | Moduladores de la agregacion de peptidos beta-amiloides que comprenden d-aminoacidos. |
US6174993B1 (en) * | 1997-05-21 | 2001-01-16 | The Children's Medical Center Corp. | Short peptides which selectively modulate the activity of serine/threonine kinases |
-
2002
- 2002-01-17 CA CA2434831A patent/CA2434831C/en not_active Expired - Lifetime
- 2002-01-17 CN CN028038320A patent/CN1545422B/zh not_active Expired - Fee Related
- 2002-01-17 JP JP2002557423A patent/JP5057628B2/ja not_active Expired - Fee Related
- 2002-01-17 AU AU2002228260A patent/AU2002228260B2/en not_active Ceased
- 2002-01-17 CN CN2010102537253A patent/CN101979093B/zh not_active Expired - Fee Related
-
2009
- 2009-06-08 JP JP2009137059A patent/JP2009235082A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1545422A (zh) | 2004-11-10 |
CN101979093A (zh) | 2011-02-23 |
CN101979093B (zh) | 2013-04-24 |
CA2434831A1 (en) | 2002-07-25 |
CN1545422B (zh) | 2010-09-22 |
JP2009235082A (ja) | 2009-10-15 |
JP5057628B2 (ja) | 2012-10-24 |
JP2005505492A (ja) | 2005-02-24 |
AU2002228260B2 (en) | 2007-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |