CA2433343C - Cosmetic compositions containing rosemary extract and dha - Google Patents
Cosmetic compositions containing rosemary extract and dha Download PDFInfo
- Publication number
- CA2433343C CA2433343C CA002433343A CA2433343A CA2433343C CA 2433343 C CA2433343 C CA 2433343C CA 002433343 A CA002433343 A CA 002433343A CA 2433343 A CA2433343 A CA 2433343A CA 2433343 C CA2433343 C CA 2433343C
- Authority
- CA
- Canada
- Prior art keywords
- dha
- rosemary extract
- weight
- composition
- active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
The present invention relates to a topical composition comprising a malodor-reducing effective amount of a rosemary extract, or active fraction thereof, in combination with a self-tanning effective amount of DHA. The invention also provides a method of reducing the potential for malodor generation of a DHA composition comprising adding to the composition an effective amount of rosemary extract or active fraction thereof.
Description
COSMETIC COMPOSITIONS CONTAINING ROSEMARY EXTRACT AND DHA
Field of the Invention The invention relates to cosmetic compositions. More specifically, the invention relates to self-tanning cosmetic compositions.
Background of the Invention With sun exposure being recognized as a significant health risk, the desirability of sitting for hours to develop a deep tan has diminished considerably in recent years. However, the desire to have that bronze glow has not diminished in a large portion of the population.
The solution for most prudent consumers is the use of self-tamzing products.
These products typically employ the compound dihydroxyacetone(DHA), which interacts with the proteins on the skin to produce a brown color approximating a sun-derived tan. In the early days of self-tanners, there were a number of problems which prevented widespread acceptance, the primary one being the unnatural orange color that would develop on some users.
However, self-tanners have iinproved tremendously in recent years, and most products currently available produce natural and fairly long-lasting color on the user. There is one remaining issue with self-tanners that continues to reduce their acceptability to the consumer: after application, inany users detect a malodor that lingers for up to 24 hours. The unpleasant odor apparently arises as a result of compounds generated on the skin upon application of the self-tanner. The only solution known to date is the incorporation of fragrance or oils that mask the odor to some extent; however, the addition of fragrance is not always an acceptable option to every product, and in any event does not address the root of the problem, i.e., neutralizing the coinpounds generated on the skin. To date, this problem continues to affect self-tanners, and therefore, may prevent their more frequent usage. The present invention now provides a solution for the odor generated upon application of the self-tanner to the slcin.
Summary of the Invention The present invention relates to a cosmetic composition comprising DHA in combination with an effective ainount of a rosemary extract or active component thereof. As used herein, the term "cosmetic composition" is intended to encompass any composition containing DHA intended for topical application to the skin, which may also include compositions that are used in therapeutic applications, for example, in conjunction with PUVA
therapy.
The invention also relates to a method of preventing or reducing the generation of malodor on the skin resulting from application of a DHA-containing self-tanner, comprising applying to the sldn a composition comprising DHA combined with an effective amount of rosemary extract.
Detailed Description of the Invention It has been unexpectedly discovered that the addition of rosemary extract to compositions containing DHA will prevent or reduce the typical malodor associated with the application of DHA compositions to the skin. Rosemary extract is a natural and known material extracted from the rosemary plant, and having established properties as an antioxidant: However, notwithstanding its known properties, in the present case, where the problem seems not to arise in degradation of the formula, but rather due to a reaction on the sldn about which very little is known, it was quite unexpected that the rosemary extract performed so remarkably.
Rosemary extract is a generic term describing a number of different chemical compositions that may contain several different active components. Among the common components that are found in rosemary exhact are carnosol, carnosic acid, methoxy carnosic acid, rosmarinic acid, rosmanol and rosmaridiphenol, in different proportions depending on the individual extract. Numerous rosemary extracts are available commercially, and any one can be used in the present invention. However, particularly preferred for use is the "Guardian"
rosemary extract available from 13arth Supplied Products. This extract contains, in a base of lecitbin, acetylated hydrogenated vegetable glycerides and propylene glycol, an active rosemary extract, in an amount of from about 12-30%, containing a minitnum of 5% phenolic diterpenes. In particular, the active portion contains a minimum of 50%
carnosic acid, camosol in an amount of 20-35%, and methoxy carnosic acid in an amount of from about 5-15%, with minor amounts of rosmanol, rosmarinic acid and rosmaridiphenol. It will be understood that the term "rosemary extract" as used herein shall encompass not only a rosemary extract per se, but also a composition to which the individual active components, such as are noted above, are added to the composition individually, or in individual combinations, from synthetic or natural sources, either from rosemary or from starting material other than rosemary, in amounts equivalent to those described in the use of the rosemary extract.
The active rosemary extract can be used in the DHA formulation in an amount of from about 0.0001 to about 50% by weight of the total composition. However, the extract is extremely efficacious, requiring only small amounts to achieve reduction in odor, so the preferred range of use of the extract is about 0.1 to about 10% by weight of the composition.
The extract can be added to any type of formulation in which DHA is ordinarily applied, for example, creams, lotions, sprays, sticks and the like, and may be aqueous, water and oil or anhydrous. The amount of DHA employed will be in line with the typical use of this material, which is generally in the range of from about 1-10%. Anotller unexpected result of the use of the rosemary extract is its lack of adverse effect on color development with DHA. DHA is a relatively unstable material, and is subject to alterations in its performance when in the presence of other incoinpatible materials. However, surprisingly, rosemary extract has no adverse effect on the color development, and in some cases even seemed to improve it.
The invention will be further understood by reference to the following non-limiting examples.
EXAMPLES
Example 1 Initial studies were perfonned to identify compounds which might assist in reducing the malodor associated with DHA application on the skin. A first attempt tested compounds generally known to have odor-reducing properties, namely, dipropylene glycol, zinc acetate, choline, and aloe vera gel. No consistent positive results were obtained with any of these compounds.
A secondary experiment was conducted on a new raw material: `Guardian' Rosemary Extract produced by Earth Supplied Products. The influence of Rosemary Extract (RME) on odor formation on 14 panelists using aqueous solutions of DHA and Rosemary Extract was investigated. Color and odor'were tested on the panelists to determine any differences in the reaction of DHA in the presence of Rosemary Extract.
Results and Discussions:
I) Clinical Study: Applications ofAqueous Solutions of DHA alone and DHA witlz R1VIE to the sltin In the presence of RME, significant odor improvement was observed on 13 / 14 panelists (0.25% RME). One panelist did not produce any malodor when DHA was applied.
The iinprovement in odor was most evident at 24 hours after the application to the skin..
Under these conditions we observed greater than 90% reduction in malodor formation.
Field of the Invention The invention relates to cosmetic compositions. More specifically, the invention relates to self-tanning cosmetic compositions.
Background of the Invention With sun exposure being recognized as a significant health risk, the desirability of sitting for hours to develop a deep tan has diminished considerably in recent years. However, the desire to have that bronze glow has not diminished in a large portion of the population.
The solution for most prudent consumers is the use of self-tamzing products.
These products typically employ the compound dihydroxyacetone(DHA), which interacts with the proteins on the skin to produce a brown color approximating a sun-derived tan. In the early days of self-tanners, there were a number of problems which prevented widespread acceptance, the primary one being the unnatural orange color that would develop on some users.
However, self-tanners have iinproved tremendously in recent years, and most products currently available produce natural and fairly long-lasting color on the user. There is one remaining issue with self-tanners that continues to reduce their acceptability to the consumer: after application, inany users detect a malodor that lingers for up to 24 hours. The unpleasant odor apparently arises as a result of compounds generated on the skin upon application of the self-tanner. The only solution known to date is the incorporation of fragrance or oils that mask the odor to some extent; however, the addition of fragrance is not always an acceptable option to every product, and in any event does not address the root of the problem, i.e., neutralizing the coinpounds generated on the skin. To date, this problem continues to affect self-tanners, and therefore, may prevent their more frequent usage. The present invention now provides a solution for the odor generated upon application of the self-tanner to the slcin.
Summary of the Invention The present invention relates to a cosmetic composition comprising DHA in combination with an effective ainount of a rosemary extract or active component thereof. As used herein, the term "cosmetic composition" is intended to encompass any composition containing DHA intended for topical application to the skin, which may also include compositions that are used in therapeutic applications, for example, in conjunction with PUVA
therapy.
The invention also relates to a method of preventing or reducing the generation of malodor on the skin resulting from application of a DHA-containing self-tanner, comprising applying to the sldn a composition comprising DHA combined with an effective amount of rosemary extract.
Detailed Description of the Invention It has been unexpectedly discovered that the addition of rosemary extract to compositions containing DHA will prevent or reduce the typical malodor associated with the application of DHA compositions to the skin. Rosemary extract is a natural and known material extracted from the rosemary plant, and having established properties as an antioxidant: However, notwithstanding its known properties, in the present case, where the problem seems not to arise in degradation of the formula, but rather due to a reaction on the sldn about which very little is known, it was quite unexpected that the rosemary extract performed so remarkably.
Rosemary extract is a generic term describing a number of different chemical compositions that may contain several different active components. Among the common components that are found in rosemary exhact are carnosol, carnosic acid, methoxy carnosic acid, rosmarinic acid, rosmanol and rosmaridiphenol, in different proportions depending on the individual extract. Numerous rosemary extracts are available commercially, and any one can be used in the present invention. However, particularly preferred for use is the "Guardian"
rosemary extract available from 13arth Supplied Products. This extract contains, in a base of lecitbin, acetylated hydrogenated vegetable glycerides and propylene glycol, an active rosemary extract, in an amount of from about 12-30%, containing a minitnum of 5% phenolic diterpenes. In particular, the active portion contains a minimum of 50%
carnosic acid, camosol in an amount of 20-35%, and methoxy carnosic acid in an amount of from about 5-15%, with minor amounts of rosmanol, rosmarinic acid and rosmaridiphenol. It will be understood that the term "rosemary extract" as used herein shall encompass not only a rosemary extract per se, but also a composition to which the individual active components, such as are noted above, are added to the composition individually, or in individual combinations, from synthetic or natural sources, either from rosemary or from starting material other than rosemary, in amounts equivalent to those described in the use of the rosemary extract.
The active rosemary extract can be used in the DHA formulation in an amount of from about 0.0001 to about 50% by weight of the total composition. However, the extract is extremely efficacious, requiring only small amounts to achieve reduction in odor, so the preferred range of use of the extract is about 0.1 to about 10% by weight of the composition.
The extract can be added to any type of formulation in which DHA is ordinarily applied, for example, creams, lotions, sprays, sticks and the like, and may be aqueous, water and oil or anhydrous. The amount of DHA employed will be in line with the typical use of this material, which is generally in the range of from about 1-10%. Anotller unexpected result of the use of the rosemary extract is its lack of adverse effect on color development with DHA. DHA is a relatively unstable material, and is subject to alterations in its performance when in the presence of other incoinpatible materials. However, surprisingly, rosemary extract has no adverse effect on the color development, and in some cases even seemed to improve it.
The invention will be further understood by reference to the following non-limiting examples.
EXAMPLES
Example 1 Initial studies were perfonned to identify compounds which might assist in reducing the malodor associated with DHA application on the skin. A first attempt tested compounds generally known to have odor-reducing properties, namely, dipropylene glycol, zinc acetate, choline, and aloe vera gel. No consistent positive results were obtained with any of these compounds.
A secondary experiment was conducted on a new raw material: `Guardian' Rosemary Extract produced by Earth Supplied Products. The influence of Rosemary Extract (RME) on odor formation on 14 panelists using aqueous solutions of DHA and Rosemary Extract was investigated. Color and odor'were tested on the panelists to determine any differences in the reaction of DHA in the presence of Rosemary Extract.
Results and Discussions:
I) Clinical Study: Applications ofAqueous Solutions of DHA alone and DHA witlz R1VIE to the sltin In the presence of RME, significant odor improvement was observed on 13 / 14 panelists (0.25% RME). One panelist did not produce any malodor when DHA was applied.
The iinprovement in odor was most evident at 24 hours after the application to the skin..
Under these conditions we observed greater than 90% reduction in malodor formation.
When the color development was compared between test and control compositions, we observed that in the presence of RME, no difference in color was evident. (In some cases, the color development was slightly improved) Therefore, while using RME
significantly reduced the malodor - there was no inhibition of the DHA color reaction as was seen previously with other ingredients tested.
Example 2 The following illustrates a composition, a water and oil emulsion, of the invention:
Material Weight %
Cyclomethicone 11.00 Cetyl Diinethicone copolyol 1.00 Cyclomethcone/PEG/PPG-18/18 dimethicone 5.00 Tocopheryl acetate 0.20 Polysilicone 7/cyclomethicone 1.50 Fragrance 0.40 Deionized water QS
DHA 4.00 Glycerin 8.00 Sodium chloride 0.80 Lactic acid 0.50 Pantethine 0.02 Cyclomethicone 2.00 Blaclc Iron oxide 0.02 Iron oxide/alumina 0.38 Mica/titanium dioxide/iron oxides/
dimethicone 0.22 Mica/iron oxides 0.14 Preservative 0.50 Rosemary extract 0.25 Cyclomethicone .1.00 Cyclomethicone/dimethicone/vinyl dimethicone crosspolymer 3.50
significantly reduced the malodor - there was no inhibition of the DHA color reaction as was seen previously with other ingredients tested.
Example 2 The following illustrates a composition, a water and oil emulsion, of the invention:
Material Weight %
Cyclomethicone 11.00 Cetyl Diinethicone copolyol 1.00 Cyclomethcone/PEG/PPG-18/18 dimethicone 5.00 Tocopheryl acetate 0.20 Polysilicone 7/cyclomethicone 1.50 Fragrance 0.40 Deionized water QS
DHA 4.00 Glycerin 8.00 Sodium chloride 0.80 Lactic acid 0.50 Pantethine 0.02 Cyclomethicone 2.00 Blaclc Iron oxide 0.02 Iron oxide/alumina 0.38 Mica/titanium dioxide/iron oxides/
dimethicone 0.22 Mica/iron oxides 0.14 Preservative 0.50 Rosemary extract 0.25 Cyclomethicone .1.00 Cyclomethicone/dimethicone/vinyl dimethicone crosspolymer 3.50
Claims (8)
1. A cosmetic self-tanning composition comprising a malodor-reducing effective amount of an active rosemary extract, or active fraction thereof, in combination with a self-tanning effective amount of dihydroxyacetone (DHA), wherein the rosemary extract comprises at least about 50% by weight carnosic acid, from about 20 to about 35% by weight carnosol, and from about 5 to about 15% by weight of methoxy carnosic acid.
2. The composition of claim 1 comprising from about 0.0001 to about 50% of an active rosemary extract, and about 1 to about 10% of DHA.
3. The composition of claim 1 comprising from about 0.1 to about 10% of an active rosemary extract.
4. A cosmetic composition comprising from about 1 to about 10% by weight of dihydroxyacetone (DHA), and about 0.1 to about 10% by weight active rosemary extract, wherein the active rosemary extract comprises at least about 50% by weight carnosic acid, from about 20 to about 35% by weight carnosol, and from about 5 to about 15%
by weight of methoxy carnosic acid.
by weight of methoxy carnosic acid.
5. A method of formulating a dihydroxyacetone (DHA)-containing composition which upon application to skin generates little or no malodor, comprising adding to a composition containing DHA a malodor-reducing effective amount of an active rosemary extract, wherein the active rosemary extract comprises at least about 50% by weight carnosic acid, from about 20 to about 35% by weight carnosol, and from about 5 to about 15% by weight of methoxy carnosic acid.
6. Use of the composition of any one of claims 1 to 4 for reducing or preventing the development of malodor on the skin associated with dihydroxyacetone (DHA).
7. Use of a malodor-reducing effective amount of an active rosemary extract, or active fraction thereof, for reducing or preventing the development of malodor on the skin associated with dihydroxyacetone (DHA)-containing compositions.
8. Use of claim 7, wherein the active rosemary extract comprises at least about 50% by weight carnosic acid, from about 20 to about 35% by weight carnosol, and from about 5 to about 15% by weight of methoxy carnosic acid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29409301P | 2001-05-29 | 2001-05-29 | |
| US60/294,093 | 2001-05-29 | ||
| PCT/US2002/016766 WO2002096371A1 (en) | 2001-05-29 | 2002-05-29 | Cosmetic compositions containing rosemary extract and dha |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2433343A1 CA2433343A1 (en) | 2002-12-05 |
| CA2433343C true CA2433343C (en) | 2009-01-06 |
Family
ID=23131844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002433343A Expired - Fee Related CA2433343C (en) | 2001-05-29 | 2002-05-29 | Cosmetic compositions containing rosemary extract and dha |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1395228A4 (en) |
| JP (2) | JP4300034B2 (en) |
| CA (1) | CA2433343C (en) |
| WO (1) | WO2002096371A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096371A1 (en) * | 2001-05-29 | 2002-12-05 | E-L Management Corp. | Cosmetic compositions containing rosemary extract and dha |
| DE102004006830A1 (en) * | 2004-02-11 | 2005-09-01 | Beiersdorf Ag | Cosmetic and dermatological self-tanning formulations |
| US20050238680A1 (en) | 2004-04-21 | 2005-10-27 | Qing Stella | Personal care compositions that deposit hydrophilic benefit agents |
| US20050239670A1 (en) * | 2004-04-21 | 2005-10-27 | Qing Stella | Personal care compositions that deposit hydrophilic benefit agents |
| US20050238595A1 (en) * | 2004-04-21 | 2005-10-27 | Qing Stella | Personal care compositions that deposit sunless tanning benefit agents |
| JP4589386B2 (en) * | 2004-07-01 | 2010-12-01 | イーエルシー マネージメント エルエルシー | Cosmetic compositions and methods containing tanning agents and liposome encapsulated ursolic acid |
| KR100871962B1 (en) | 2004-07-01 | 2008-12-08 | 이-엘 매니지먼트 코포레이션 | Cosmetic compositions and methods containing a tanning agent and liposome-encapsulated ursolic acid |
| DE102006017879A1 (en) * | 2006-04-13 | 2007-10-25 | Merck Patent Gmbh | Use of flavonoids |
| DE102006040276A1 (en) * | 2006-08-17 | 2008-02-21 | Technische Universität Dresden | Use of mono- or disaccharides to mask odors, and methods and composition for masking odors |
| WO2013156859A2 (en) * | 2012-04-20 | 2013-10-24 | Kao Corporation | Self-tanning cosmetic |
| JP6960742B2 (en) * | 2017-02-07 | 2021-11-05 | サントリーホールディングス株式会社 | Beer-taste beverages and their manufacturing methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57204278A (en) * | 1981-06-11 | 1982-12-14 | Lion Corp | Preparation of deodorizing substance |
| JPS59103665A (en) * | 1982-12-03 | 1984-06-15 | ライオン株式会社 | Deodorant |
| FR2695034B1 (en) * | 1992-09-01 | 1994-10-07 | Oreal | Cosmetic or pharmaceutical composition comprising in combination a peroxidase and a singlet anti-oxygen agent. |
| JP2866741B2 (en) * | 1993-03-31 | 1999-03-08 | シェリング−プラウ・ヘルスケア・プロダクツ・インコーポレーテッド | Method and apparatus for sunless tanning |
| DE4441470A1 (en) * | 1993-11-25 | 1995-06-01 | Merck Patent Gmbh | Skin colouring compsn. for durable, high intensity natural tan tones |
| JP3625976B2 (en) * | 1997-01-30 | 2005-03-02 | 高砂香料工業株式会社 | Deodorant composition |
| JPH1113150A (en) * | 1997-06-23 | 1999-01-19 | Nakamura:Kk | Bond anchor method |
| WO2002096371A1 (en) * | 2001-05-29 | 2002-12-05 | E-L Management Corp. | Cosmetic compositions containing rosemary extract and dha |
-
2002
- 2002-05-29 WO PCT/US2002/016766 patent/WO2002096371A1/en active Application Filing
- 2002-05-29 JP JP2002592884A patent/JP4300034B2/en not_active Expired - Fee Related
- 2002-05-29 EP EP02737222A patent/EP1395228A4/en not_active Withdrawn
- 2002-05-29 CA CA002433343A patent/CA2433343C/en not_active Expired - Fee Related
-
2006
- 2006-09-06 JP JP2006241725A patent/JP2007016045A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002096371A1 (en) | 2002-12-05 |
| JP2007016045A (en) | 2007-01-25 |
| CA2433343A1 (en) | 2002-12-05 |
| JP4300034B2 (en) | 2009-07-22 |
| JP2004520447A (en) | 2004-07-08 |
| EP1395228A4 (en) | 2004-10-13 |
| EP1395228A1 (en) | 2004-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5910311A (en) | Composition containing a non-photocatalytic metal oxide and tocopherol, its use in the cosmetics and/or dermatological field and processes employing it | |
| US6641845B1 (en) | Skin whitening composition comprising bearberry and tetrahydrocurcumin | |
| JP2007016045A (en) | Cosmetic compositions containing rosemary extract and dha | |
| CA2156623C (en) | Skin care composition | |
| US20060233725A1 (en) | Non-Endocrine Disrupting Cytoprotective UV Radiation Resistant Substance | |
| EP2160186A2 (en) | Creatine compositions for skin treatment | |
| US7223382B2 (en) | Cosmetic compositions containing rosemary extract and DHA | |
| US5552158A (en) | Skin care composition | |
| CA3018131A1 (en) | An antimicrobial composition comprising thymol, terpineol and a cationic phospholipid | |
| JP2676049B2 (en) | Skin cosmetics | |
| AU7733401A (en) | Method for promoting clear skin | |
| CZ31798A3 (en) | Cosmetic way of treating and prevention signs of skin ageing | |
| CA3181110A1 (en) | An antimicrobial composition for tackling malodour | |
| EP0949864A1 (en) | Self tanning compositions containing dha and alpha hydroxy acids | |
| JP2004155690A (en) | Hair tonic composition | |
| JPS62267214A (en) | Dermatic agent for external use | |
| JPH072640A (en) | External preparation for protecting ultraviolet disorder | |
| JP2006315957A (en) | Singlet oxygen scavenger and external preparation for skin using the same | |
| JP2001131025A (en) | Cosmetic for scalp and hair | |
| JPH0193509A (en) | Skin drug for external use | |
| KR102419399B1 (en) | Cica-care cream composition and manufacturing method thereof | |
| JPS6028926A (en) | External preparation for skin | |
| JP2003183113A (en) | Composition for external use | |
| JP2006335761A (en) | Sustained release deodorizing composition | |
| JPH03275607A (en) | Water-containing cosmetic composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20110530 |