CA2430127C - Aqueous disinfecting system comprising a microbicide and 1,3-bis(tris[hydroxymethyl]methylamino)propane - Google Patents
Aqueous disinfecting system comprising a microbicide and 1,3-bis(tris[hydroxymethyl]methylamino)propane Download PDFInfo
- Publication number
- CA2430127C CA2430127C CA2430127A CA2430127A CA2430127C CA 2430127 C CA2430127 C CA 2430127C CA 2430127 A CA2430127 A CA 2430127A CA 2430127 A CA2430127 A CA 2430127A CA 2430127 C CA2430127 C CA 2430127C
- Authority
- CA
- Canada
- Prior art keywords
- aqueous solution
- bis
- tris
- propane
- solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003641 microbiacidal effect Effects 0.000 title claims abstract description 28
- 229940124561 microbicide Drugs 0.000 title claims abstract description 28
- HHKZCCWKTZRCCL-UHFFFAOYSA-N bis-tris propane Chemical compound OCC(CO)(CO)NCCCNC(CO)(CO)CO HHKZCCWKTZRCCL-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 239000002855 microbicide agent Substances 0.000 title claims abstract description 20
- 230000000249 desinfective effect Effects 0.000 title abstract description 27
- 239000000243 solution Substances 0.000 claims abstract description 59
- 239000000203 mixture Substances 0.000 claims abstract description 39
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 18
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229950010221 alexidine Drugs 0.000 claims abstract description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 18
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000012929 tonicity agent Substances 0.000 claims description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 229960001484 edetic acid Drugs 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 2
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 229940067606 lecithin Drugs 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229920002113 octoxynol Polymers 0.000 claims description 2
- 229940066429 octoxynol Drugs 0.000 claims description 2
- 229960003330 pentetic acid Drugs 0.000 claims description 2
- 229920001987 poloxamine Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims description 2
- 229960004224 tyloxapol Drugs 0.000 claims description 2
- 229920001664 tyloxapol Polymers 0.000 claims description 2
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 14
- 239000000872 buffer Substances 0.000 description 14
- 238000009472 formulation Methods 0.000 description 14
- 239000007989 BIS-Tris Propane buffer Substances 0.000 description 13
- 239000000645 desinfectant Substances 0.000 description 10
- 239000001294 propane Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 239000008363 phosphate buffer Substances 0.000 description 8
- 241000222122 Candida albicans Species 0.000 description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 7
- 229940095731 candida albicans Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000009467 reduction Effects 0.000 description 7
- 235000002639 sodium chloride Nutrition 0.000 description 7
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 229920001400 block copolymer Polymers 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- QZTKDVCDBIDYMD-UHFFFAOYSA-N 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid Chemical compound NC(=O)CN(CC(O)=O)CC(O)=O QZTKDVCDBIDYMD-UHFFFAOYSA-N 0.000 description 3
- IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
- AJTVSSFTXWNIRG-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanesulfonic acid Chemical compound OCC[NH+](CCO)CCS([O-])(=O)=O AJTVSSFTXWNIRG-UHFFFAOYSA-N 0.000 description 3
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 3
- XCBLFURAFHFFJF-UHFFFAOYSA-N 3-[bis(2-hydroxyethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCCN(CCO)CC(O)CS(O)(=O)=O XCBLFURAFHFFJF-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DBXNUXBLKRLWFA-UHFFFAOYSA-N N-(2-acetamido)-2-aminoethanesulfonic acid Chemical compound NC(=O)CNCCS(O)(=O)=O DBXNUXBLKRLWFA-UHFFFAOYSA-N 0.000 description 3
- JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 239000006177 biological buffer Substances 0.000 description 3
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 238000010494 dissociation reaction Methods 0.000 description 3
- 230000005593 dissociations Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- NUFBIAUZAMHTSP-UHFFFAOYSA-N 3-(n-morpholino)-2-hydroxypropanesulfonic acid Chemical compound OS(=O)(=O)CC(O)CN1CCOCC1 NUFBIAUZAMHTSP-UHFFFAOYSA-N 0.000 description 2
- RZQXOGQSPBYUKH-UHFFFAOYSA-N 3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCC(CO)(CO)NCC(O)CS(O)(=O)=O RZQXOGQSPBYUKH-UHFFFAOYSA-N 0.000 description 2
- 239000007991 ACES buffer Substances 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 239000007993 MOPS buffer Substances 0.000 description 2
- 239000007990 PIPES buffer Substances 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 239000008366 buffered solution Substances 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000008174 sterile solution Substances 0.000 description 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- NFAOATPOYUWEHM-UHFFFAOYSA-N 2-(6-methylheptyl)phenol Chemical compound CC(C)CCCCCC1=CC=CC=C1O NFAOATPOYUWEHM-UHFFFAOYSA-N 0.000 description 1
- YEXLBQKAMAHZLN-UHFFFAOYSA-N 2-[3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propylamino]-2-(hydroxymethyl)propane-1,3-diol;propane Chemical compound CCC.OCC(CO)(CO)NCCCNC(CO)(CO)CO YEXLBQKAMAHZLN-UHFFFAOYSA-N 0.000 description 1
- VTOWJTPBPWTSMK-UHFFFAOYSA-N 4-morpholin-4-ylbutane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCN1CCOCC1 VTOWJTPBPWTSMK-UHFFFAOYSA-N 0.000 description 1
- ISAVYTVYFVQUDY-UHFFFAOYSA-N 4-tert-Octylphenol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 ISAVYTVYFVQUDY-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 108700016232 Arg(2)-Sar(4)- dermorphin (1-4) Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108091005658 Basic proteases Proteins 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000427940 Fusarium solani Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000065698 Teredo navalis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960003168 bronopol Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229960004867 hexetidine Drugs 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229960002163 hydrogen peroxide Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical class CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002997 ophthalmic solution Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000015227 regulation of liquid surface tension Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25375700P | 2000-11-29 | 2000-11-29 | |
| US60/253,757 | 2000-11-29 | ||
| PCT/EP2001/013835 WO2002043482A2 (en) | 2000-11-29 | 2001-11-27 | Aqueous disinfecting systems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2430127A1 CA2430127A1 (en) | 2002-06-06 |
| CA2430127C true CA2430127C (en) | 2010-04-20 |
Family
ID=22961578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2430127A Expired - Lifetime CA2430127C (en) | 2000-11-29 | 2001-11-27 | Aqueous disinfecting system comprising a microbicide and 1,3-bis(tris[hydroxymethyl]methylamino)propane |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7419944B2 (enExample) |
| EP (1) | EP1339278B1 (enExample) |
| JP (1) | JP4322503B2 (enExample) |
| KR (1) | KR20030068148A (enExample) |
| CN (1) | CN1477929A (enExample) |
| AR (1) | AR031417A1 (enExample) |
| AT (1) | ATE284138T1 (enExample) |
| AU (1) | AU2002233204A1 (enExample) |
| BR (1) | BR0115693A (enExample) |
| CA (1) | CA2430127C (enExample) |
| DE (1) | DE60107715T2 (enExample) |
| HU (1) | HUP0302161A3 (enExample) |
| MX (1) | MXPA03004816A (enExample) |
| NO (1) | NO20032324L (enExample) |
| TW (1) | TW496745B (enExample) |
| WO (1) | WO2002043482A2 (enExample) |
| ZA (1) | ZA200303628B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2545962A1 (en) * | 2003-12-09 | 2005-07-07 | Alcon, Inc. | Use of organic buffering agents to enhance the antimicrobial activity of pharmaceutical compositions |
| US7445771B2 (en) | 2003-12-09 | 2008-11-04 | Alcon, Inc. | Use of bis-amines to enhance the antimicrobial activity of aqueous compositions |
| US20060141059A1 (en) * | 2004-12-27 | 2006-06-29 | Alcon, Inc. | Self-preserved ophthalmic pharmaceutical compositions containing tobramycin |
| EP1998907B1 (en) | 2006-02-28 | 2011-02-16 | Cellular Bioengineering, Inc. | Polymer composition and method for removing contaminates from a substrate |
| US20070287752A1 (en) * | 2006-06-08 | 2007-12-13 | Burke Susan E | Ophthalmic Compositions Comprising A Branched, Glycerol Compound |
| TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
| WO2008036855A2 (en) * | 2006-09-21 | 2008-03-27 | Alcon Research, Ltd. | Self-preserved aqueous pharmaceutical compositions |
| PL2066300T5 (pl) * | 2006-09-28 | 2020-03-31 | Novartis Ag | Samokonserwujące wodne kompozycje farmaceutyczne |
| JP2010531168A (ja) * | 2007-06-19 | 2010-09-24 | セルラー・バイオエンジニアリング・インコーポレイテッド | 微生物及び／又は感染体を処理する方法 |
| WO2008157670A2 (en) * | 2007-06-19 | 2008-12-24 | Cellular Bioengineering, Inc. | Method for protecting substrates and removing contaminants from such substrates |
| AU2009225931B9 (en) * | 2008-03-17 | 2014-04-03 | Novartis Ag | Aqueous pharmaceutical compositions containing borate-polyol complexes |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| GB0818869D0 (en) * | 2008-10-15 | 2008-11-19 | Byotrol Plc | Anti-microbial composition |
| TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
| EP2742510A1 (en) | 2011-08-11 | 2014-06-18 | Cellular Bioengineering, Inc. | Polymer composition |
| US9132106B2 (en) * | 2013-03-14 | 2015-09-15 | Abbott Medical Optics Inc. | Synergistic ophthalmic compositions for disinfecting contact lenses |
| EP3324739A4 (en) * | 2015-07-24 | 2019-02-13 | Teleflex Medical Incorporated | ANTIMICROBIAL COMPOSITIONS FOR SURGICAL APPLICATIONS |
| JP2020535155A (ja) | 2017-09-26 | 2020-12-03 | エコラボ ユーエスエー インコーポレイティド | 酸性／アニオン性抗菌および殺ウイルス組成物ならびにその使用 |
| US12010996B2 (en) | 2018-11-08 | 2024-06-18 | Hwang Hsing Chen | Tris-substituted biguanide compounds and their uses |
| US12053540B2 (en) | 2018-12-04 | 2024-08-06 | Virox Technologies Inc. | Antimicrobial compositions containing solvents including a C3-C5 N-alkyl-gamma-butyrolactam |
| BR112021006553A2 (pt) | 2018-12-04 | 2021-07-13 | Virox Technologies Inc. | composições antimicrobianas contendo c3-c5 n-alquil-gama-butirolactama e usos dos mesmos |
| US12052990B2 (en) | 2018-12-04 | 2024-08-06 | Virox Technologies Inc. | C3-C5 n-alkyl-gamma-butyrolactam containing antimicrobial compositions and methods of using same |
| WO2021126956A1 (en) | 2019-12-16 | 2021-06-24 | Ecolab Usa Inc. | Anionic surfactant impact on virucidal efficacy |
| CN115777722B (zh) * | 2022-11-30 | 2024-04-30 | 华中农业大学 | 阿来西定二盐酸盐在抑制植物病原菌的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1432345A (en) | 1972-04-13 | 1976-04-14 | Smith Enphew Research Ltd | Ophthalmic compositions and contact lens disinfecting compo sitions |
| US4758595A (en) * | 1984-12-11 | 1988-07-19 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| CA2098299C (en) * | 1990-12-27 | 1997-05-20 | Mary Mowrey-Mckee | Method and composition for disinfecting contact lenses |
| DK172894B1 (da) | 1991-01-03 | 1999-09-27 | Niels Aage Aunsholt | Hæmodialyseapparat |
| US5312749A (en) * | 1992-05-12 | 1994-05-17 | The United States Of America As Represented By The Secretary Of Agriculture | Industrial alkaline protease from shipworm bacterium |
| GB9320782D0 (en) | 1993-10-08 | 1993-12-01 | Univ Leeds Innovations Ltd | Stabilising of proteins on solution |
| JP3883739B2 (ja) * | 1998-05-22 | 2007-02-21 | 株式会社メニコン | コンタクトレンズ用殺菌液 |
| US6162393A (en) * | 1998-08-06 | 2000-12-19 | Ndt, Inc. | Contact lens and ophthalmic solutions |
| US7067547B1 (en) * | 1999-11-04 | 2006-06-27 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions comprising imidazole |
| JP2001356307A (ja) * | 2000-06-14 | 2001-12-26 | Menicon Co Ltd | コンタクトレンズ用液 |
| DK1339418T3 (da) * | 2000-11-08 | 2009-12-14 | Fxs Ventures Llc | Forbedret ophthalmiske og kontaktlinseoplösninger indeholdende simple saccharider som konserverende forstærkere |
-
2001
- 2001-11-27 BR BR0115693-4A patent/BR0115693A/pt not_active Application Discontinuation
- 2001-11-27 EP EP01984771A patent/EP1339278B1/en not_active Expired - Lifetime
- 2001-11-27 TW TW090129253A patent/TW496745B/zh not_active IP Right Cessation
- 2001-11-27 AU AU2002233204A patent/AU2002233204A1/en not_active Abandoned
- 2001-11-27 WO PCT/EP2001/013835 patent/WO2002043482A2/en not_active Ceased
- 2001-11-27 CN CNA018197817A patent/CN1477929A/zh active Pending
- 2001-11-27 CA CA2430127A patent/CA2430127C/en not_active Expired - Lifetime
- 2001-11-27 KR KR10-2003-7006333A patent/KR20030068148A/ko not_active Withdrawn
- 2001-11-27 JP JP2002545472A patent/JP4322503B2/ja not_active Expired - Fee Related
- 2001-11-27 HU HU0302161A patent/HUP0302161A3/hu unknown
- 2001-11-27 AR ARP010105503A patent/AR031417A1/es unknown
- 2001-11-27 MX MXPA03004816A patent/MXPA03004816A/es unknown
- 2001-11-27 DE DE60107715T patent/DE60107715T2/de not_active Expired - Lifetime
- 2001-11-27 AT AT01984771T patent/ATE284138T1/de not_active IP Right Cessation
- 2001-11-29 US US09/997,099 patent/US7419944B2/en not_active Expired - Lifetime
-
2003
- 2003-05-12 ZA ZA200303628A patent/ZA200303628B/en unknown
- 2003-05-22 NO NO20032324A patent/NO20032324L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002043482A2 (en) | 2002-06-06 |
| TW496745B (en) | 2002-08-01 |
| HUP0302161A3 (en) | 2005-01-28 |
| EP1339278B1 (en) | 2004-12-08 |
| CN1477929A (zh) | 2004-02-25 |
| HUP0302161A2 (hu) | 2003-09-29 |
| EP1339278A2 (en) | 2003-09-03 |
| ZA200303628B (en) | 2004-04-23 |
| BR0115693A (pt) | 2003-09-09 |
| AR031417A1 (es) | 2003-09-24 |
| JP2004525087A (ja) | 2004-08-19 |
| KR20030068148A (ko) | 2003-08-19 |
| ATE284138T1 (de) | 2004-12-15 |
| JP4322503B2 (ja) | 2009-09-02 |
| NO20032324D0 (no) | 2003-05-22 |
| US7419944B2 (en) | 2008-09-02 |
| MXPA03004816A (es) | 2003-09-25 |
| NO20032324L (no) | 2003-05-22 |
| DE60107715D1 (de) | 2005-01-13 |
| DE60107715T2 (de) | 2005-12-08 |
| AU2002233204A1 (en) | 2002-06-11 |
| CA2430127A1 (en) | 2002-06-06 |
| US20020122831A1 (en) | 2002-09-05 |
| WO2002043482A3 (en) | 2002-11-14 |
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Legal Events
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20211129 |