CA2429526C - Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine - Google Patents

Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine Download PDF

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Publication number
CA2429526C
CA2429526C CA2429526A CA2429526A CA2429526C CA 2429526 C CA2429526 C CA 2429526C CA 2429526 A CA2429526 A CA 2429526A CA 2429526 A CA2429526 A CA 2429526A CA 2429526 C CA2429526 C CA 2429526C
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Prior art keywords
cells
tcpp
sample
fluorescence
cell
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Expired - Lifetime
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CA2429526A
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CA2429526A1 (fr
Inventor
Jeffrey L. Garwin
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Bioaffinity Technologies Inc
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Individual
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Abstract

L'invention concerne un procédé pour détecter des états précancéreux dans des échantillons cellulaires et tissulaires, ledit procédé consistant à mettre un échantillon en incubation dans de la 5, 10, 15, 20-tétrakis (carboxyphényl) porphine (TCPP) solubilisée, à mesurer la fluorescence de la TCPP dans l'échantillon, et à classer ce dernier en tant que non-cancéreux, précancéreux ou cancéreux, en fonction de la fluorescence de la TCPP, en corrélation avec les états respectifs des cellules. En conjonction avec ce procédé de détection, un procédé nouveau et plus efficace pour solubiliser la TCPP est présenté, ainsi qu'une composition contenant de la TCPP solubilisée selon ce procédé.
CA2429526A 2000-11-17 2001-11-19 Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine Expired - Lifetime CA2429526C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2725716A CA2725716C (fr) 2000-11-17 2001-11-19 Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24950500P 2000-11-17 2000-11-17
US60/249,505 2000-11-17
PCT/US2001/043238 WO2002042267A2 (fr) 2000-11-17 2001-11-19 Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2725716A Division CA2725716C (fr) 2000-11-17 2001-11-19 Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine

Publications (2)

Publication Number Publication Date
CA2429526A1 CA2429526A1 (fr) 2002-05-30
CA2429526C true CA2429526C (fr) 2011-03-15

Family

ID=22943735

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2725716A Expired - Lifetime CA2725716C (fr) 2000-11-17 2001-11-19 Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine
CA2429526A Expired - Lifetime CA2429526C (fr) 2000-11-17 2001-11-19 Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2725716A Expired - Lifetime CA2725716C (fr) 2000-11-17 2001-11-19 Compositions et procedes pour detecter des etats precancereux dans des echantillons cellulaires et tissulaires au moyen de la 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine

Country Status (11)

Country Link
US (8) US6838248B2 (fr)
EP (2) EP2372361B1 (fr)
JP (3) JP4307070B2 (fr)
CN (1) CN1545557A (fr)
AT (1) ATE541214T1 (fr)
AU (2) AU2002239269B2 (fr)
CA (2) CA2725716C (fr)
DK (2) DK2372361T3 (fr)
ES (2) ES2523378T3 (fr)
MX (1) MXPA03004406A (fr)
WO (1) WO2002042267A2 (fr)

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US8213005B2 (en) 2003-07-22 2012-07-03 King Saud University Method for discriminating between benign and malignant prostate tumors
US7869033B2 (en) * 2003-12-24 2011-01-11 Vadivel Masilamani Cancer detection by optical analysis of body fluids
US8208142B2 (en) * 2003-12-24 2012-06-26 King Salid University Lung cancer detection by optical analysis of body fluids
EP2270712A1 (fr) * 2009-06-30 2011-01-05 Koninklijke Philips Electronics N.V. Procédé de détection de qualité et dispositif d'échantillons de cellules et de tissus
CN103168234B (zh) * 2009-07-17 2015-11-25 保爱菲技术公司 用于分析被5，10，15，20四(4-羧基苯基)卟吩(tcpp)标记的样品的系统和方法
JP6109744B2 (ja) * 2010-11-12 2017-04-05 インセルディーエックス・インコーポレーテッド 子宮頸部細胞の浮遊試料から、対象が子宮頸部上皮内腫瘍（ｃｉｎ）病変を有するかどうかを予測するための方法およびシステム
US9230063B2 (en) * 2011-01-05 2016-01-05 The Board Of Trustees Of The University Of Illinois Automated prostate tissue referencing for cancer detection and diagnosis
US9779283B2 (en) 2011-01-05 2017-10-03 The Board Of Trustees Of The University Of Illinois Automated prostate tissue referencing for cancer detection and diagnosis
CN104379760B (zh) * 2012-04-05 2018-03-16 Bd公司 用于流式细胞术的样品制备
US9933341B2 (en) 2012-04-05 2018-04-03 Becton, Dickinson And Company Sample preparation for flow cytometry
AU2014203882B2 (en) * 2013-01-07 2016-06-23 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
AU2014234992B2 (en) 2013-03-15 2018-01-18 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
EP3537151A1 (fr) 2013-04-11 2019-09-11 Cytocore, Inc. Procédés d'évaluation d'échantillons biologiques au moyen de la cytologie et de l'immunologie
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
EP3471774A4 (fr) 2016-06-16 2020-04-15 Oncoselect Therapeutics, LLC Composés de porphyrine et compositions utiles pour le traitement du cancer
MX2020010825A (es) * 2018-04-13 2021-01-15 Bioaffinity Tech Inc Sistema y metodo para determinar la salud pulmonar.
US20240118284A1 (en) * 2019-10-18 2024-04-11 The Regents Of The University Of California Compositions and methods for detecting plxdc1 and plxcd2 in human tissues
TW202128161A (zh) 2019-10-18 2021-08-01 美國加利福尼亞大學董事會 用於靶向病原性血管之化合物及方法
CN110927369A (zh) * 2019-12-11 2020-03-27 安徽安龙基因科技有限公司 一种利用tcpp联合cep探针鉴定循环肿瘤细胞的试剂盒及应用

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Also Published As

Publication number Publication date
CN1545557A (zh) 2004-11-10
JP2011185947A (ja) 2011-09-22
US8975038B2 (en) 2015-03-10
AU2002239269B2 (en) 2008-08-21
US20100216169A1 (en) 2010-08-26
EP1364044A4 (fr) 2008-11-26
EP1364044A2 (fr) 2003-11-26
JP4307070B2 (ja) 2009-08-05
US20090004690A1 (en) 2009-01-01
DK1364044T3 (da) 2012-05-07
US20050079561A1 (en) 2005-04-14
ES2523378T3 (es) 2014-11-25
US7384764B2 (en) 2008-06-10
WO2002042267A3 (fr) 2003-07-10
JP4768005B2 (ja) 2011-09-07
CA2429526A1 (fr) 2002-05-30
CA2725716C (fr) 2015-02-10
US6838248B2 (en) 2005-01-04
JP2004536275A (ja) 2004-12-02
WO2002042267A2 (fr) 2002-05-30
US20050233410A1 (en) 2005-10-20
US7960138B2 (en) 2011-06-14
CA2725716A1 (fr) 2002-05-30
EP1364044B1 (fr) 2012-01-11
DK2372361T3 (da) 2014-11-10
US20020115121A1 (en) 2002-08-22
JP2009020122A (ja) 2009-01-29
MXPA03004406A (es) 2004-10-15
US20120149057A1 (en) 2012-06-14
US7670799B2 (en) 2010-03-02
US20150177245A1 (en) 2015-06-25
US9417241B2 (en) 2016-08-16
US20140162287A1 (en) 2014-06-12
EP2372361A1 (fr) 2011-10-05
US8486656B2 (en) 2013-07-16
ATE541214T1 (de) 2012-01-15
EP2372361B1 (fr) 2014-08-06
ES2380261T3 (es) 2012-05-10
AU3926902A (en) 2002-06-03

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