CA2428018A1 - Tetrapartate prodrugs - Google Patents

Tetrapartate prodrugs Download PDF

Info

Publication number
CA2428018A1
CA2428018A1 CA002428018A CA2428018A CA2428018A1 CA 2428018 A1 CA2428018 A1 CA 2428018A1 CA 002428018 A CA002428018 A CA 002428018A CA 2428018 A CA2428018 A CA 2428018A CA 2428018 A1 CA2428018 A1 CA 2428018A1
Authority
CA
Canada
Prior art keywords
compound
substituted
group
moiety
alkyls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002428018A
Other languages
English (en)
French (fr)
Inventor
Richard B. Greenwald
Hong Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/758,993 external-priority patent/US6720306B2/en
Application filed by Individual filed Critical Individual
Publication of CA2428018A1 publication Critical patent/CA2428018A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
CA002428018A 2000-12-01 2001-11-30 Tetrapartate prodrugs Abandoned CA2428018A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72851200A 2000-12-01 2000-12-01
US09/728,512 2000-12-01
US09/758,993 US6720306B2 (en) 1997-12-17 2001-01-12 Tetrapartate prodrugs
US09/758,993 2001-01-12
PCT/US2001/045127 WO2002043663A2 (en) 2000-12-01 2001-11-30 Tetrapartate prodrugs

Publications (1)

Publication Number Publication Date
CA2428018A1 true CA2428018A1 (en) 2002-06-06

Family

ID=27111706

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002428018A Abandoned CA2428018A1 (en) 2000-12-01 2001-11-30 Tetrapartate prodrugs

Country Status (5)

Country Link
EP (1) EP1343494A4 (ja)
JP (1) JP2004518776A (ja)
AU (1) AU2002239405A1 (ja)
CA (1) CA2428018A1 (ja)
WO (1) WO2002043663A2 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
DE60318942T2 (de) * 2002-05-08 2009-02-26 Medical Enzymes Ag Schutzreagenzien enthaltend aktive kohlenhydrate für chemische modifizierungen, deren herstellung und verwendung
WO2005030835A1 (ja) * 2003-09-25 2005-04-07 Terumo Kabushiki Kaisha ポリエチレングリコール誘導体及びこれを膜構成成分とする薬物担体
CN100415801C (zh) * 2003-10-28 2008-09-03 北京键凯科技有限公司 聚乙二醇氨基酸n-内环羰酐活性衍生物及其药物键合物和凝胶
CN100543063C (zh) * 2006-04-03 2009-09-23 中国科学院过程工程研究所 氨基酸端基聚乙二醇及其制备方法
MX2009002859A (es) * 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos.
MX2009002854A (es) * 2006-09-15 2009-03-27 Enzon Pharmaceuticals Inc Oxidos de polialquileno que tienen enlazadores biodegradables a base de ester impedido.
DE102011118029A1 (de) 2011-06-20 2012-12-20 Universität Leipzig Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung
EP2917183A1 (en) * 2012-11-12 2015-09-16 Ignyta, Inc. Bendamustine derivatives and methods of using same
AU2014333954C1 (en) 2013-10-08 2020-08-27 Ascendis Pharma A/S Protecting group comprising a purification tag

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501052D0 (en) * 1995-01-19 1995-03-08 Cancer Res Campaign Tech Improvements relating to prodrugs
DE69533615T2 (de) * 1995-06-27 2005-10-13 Pharmachemie B.V. Anthracyclin Prodrugs, Verfahren zu deren Herstellung und deren Verwendung in der selektiven Chemotherapie
WO1999030727A1 (en) * 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents

Also Published As

Publication number Publication date
EP1343494A2 (en) 2003-09-17
WO2002043663A2 (en) 2002-06-06
WO2002043663A3 (en) 2002-07-25
AU2002239405A1 (en) 2002-06-11
EP1343494A4 (en) 2005-08-03
JP2004518776A (ja) 2004-06-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead