CA2425456A1 - Apparatus and methods for affinity capture tandem mass spectrometry - Google Patents

Apparatus and methods for affinity capture tandem mass spectrometry Download PDF

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Publication number
CA2425456A1
CA2425456A1 CA002425456A CA2425456A CA2425456A1 CA 2425456 A1 CA2425456 A1 CA 2425456A1 CA 002425456 A CA002425456 A CA 002425456A CA 2425456 A CA2425456 A CA 2425456A CA 2425456 A1 CA2425456 A1 CA 2425456A1
Authority
CA
Canada
Prior art keywords
probe
analytical instrument
laser
protein
affinity capture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002425456A
Other languages
English (en)
French (fr)
Inventor
James R. Mcnabb
Alexander Laboda
Werner Ens
Victor L. Spicer
Kenneth G. Standing
Scot Weinberger
Pete Tornatore
Raymond G. Bryan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspira Womens Health Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2425456A1 publication Critical patent/CA2425456A1/en
Abandoned legal-status Critical Current

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Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/62Detectors specially adapted therefor
    • G01N30/72Mass spectrometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/16Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Urology & Nephrology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electron Tubes For Measurement (AREA)
CA002425456A 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry Abandoned CA2425456A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028163 WO2002031491A2 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry

Publications (1)

Publication Number Publication Date
CA2425456A1 true CA2425456A1 (en) 2002-04-18

Family

ID=21741880

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002425456A Abandoned CA2425456A1 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry

Country Status (8)

Country Link
EP (1) EP1327256A2 (https=)
JP (1) JP2004524511A (https=)
KR (1) KR20040010541A (https=)
CN (1) CN1502116A (https=)
AU (1) AU2001210807A1 (https=)
CA (1) CA2425456A1 (https=)
IL (1) IL154932A0 (https=)
WO (1) WO2002031491A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
AU2002358219A1 (en) * 2001-12-21 2003-07-15 Sense Proteomic Limited Protein analysis using mass spectrometry
US7064319B2 (en) * 2003-03-31 2006-06-20 Hitachi High-Technologies Corporation Mass spectrometer
JP4605344B2 (ja) * 2003-06-10 2011-01-05 直久 友杉 シェーグレン症候群患者の検定方法
GB0404106D0 (en) * 2004-02-24 2004-03-31 Shimadzu Res Lab Europe Ltd An ion trap and a method for dissociating ions in an ion trap
JP4522910B2 (ja) * 2005-05-30 2010-08-11 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析装置
KR100805775B1 (ko) * 2005-08-08 2008-02-21 한국기초과학지원연구원 변형된 폴리펩티드(Modifiedpolypeptide)의 서열 및 변형 정보를 분석하는방법
US8809770B2 (en) * 2010-09-15 2014-08-19 Dh Technologies Development Pte. Ltd. Data independent acquisition of product ion spectra and reference spectra library matching
US9202677B2 (en) * 2012-05-18 2015-12-01 Dh Technologies Development Pte. Ltd. Systems and methods for using interleaving window widths in tandem mass spectrometry
KR101559101B1 (ko) * 2013-11-28 2015-10-12 한국기초과학지원연구원 혈액유래 암 진단용 펩티드 마커 및 이를 이용한 암 진단방법
CN113049663B (zh) * 2021-01-27 2023-10-20 中国科学院成都生物研究所 一维线材样品转储及质谱分析的装置和使用方法
CN115184530B (zh) * 2022-08-19 2023-11-24 北京中医药大学 一种多级在线能量分辨质谱法及其在结构精准鉴定中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements

Also Published As

Publication number Publication date
IL154932A0 (en) 2003-10-31
CN1502116A (zh) 2004-06-02
EP1327256A2 (en) 2003-07-16
KR20040010541A (ko) 2004-01-31
WO2002031491A3 (en) 2003-01-09
JP2004524511A (ja) 2004-08-12
WO2002031491A2 (en) 2002-04-18
AU2001210807A1 (en) 2002-04-22

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Legal Events

Date Code Title Description
FZDE Discontinued