CA2425221A1 - Protein c or activated protein c-like molecules - Google Patents
Protein c or activated protein c-like molecules Download PDFInfo
- Publication number
- CA2425221A1 CA2425221A1 CA002425221A CA2425221A CA2425221A1 CA 2425221 A1 CA2425221 A1 CA 2425221A1 CA 002425221 A CA002425221 A CA 002425221A CA 2425221 A CA2425221 A CA 2425221A CA 2425221 A1 CA2425221 A1 CA 2425221A1
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- Prior art keywords
- polypeptide
- conjugate
- group
- amino acid
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- JYXKLAOSCQDVIX-NFMYELBMSA-K trisodium (E)-but-2-enedioate (E)-4-hydroxy-4-oxobut-2-enoate Chemical compound [Na+].[Na+].[Na+].OC(=O)\C=C\C([O-])=O.[O-]C(=O)\C=C\C([O-])=O JYXKLAOSCQDVIX-NFMYELBMSA-K 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- 108010051110 tyrosyl-lysine Proteins 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24226800P | 2000-10-18 | 2000-10-18 | |
| DKPA200001560 | 2000-10-18 | ||
| US60/242,268 | 2000-10-18 | ||
| DKPA200001560 | 2000-10-18 | ||
| US30015401P | 2001-06-21 | 2001-06-21 | |
| DKPA200100970 | 2001-06-21 | ||
| US60/300,154 | 2001-06-21 | ||
| DKPA200100970 | 2001-06-21 | ||
| PCT/DK2001/000679 WO2002032461A2 (en) | 2000-10-18 | 2001-10-15 | Protein c or activated protein c-like molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2425221A1 true CA2425221A1 (en) | 2002-04-25 |
Family
ID=27439828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002425221A Abandoned CA2425221A1 (en) | 2000-10-18 | 2001-10-15 | Protein c or activated protein c-like molecules |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030027299A1 (enExample) |
| EP (1) | EP1328622A2 (enExample) |
| JP (1) | JP4071105B2 (enExample) |
| KR (1) | KR20030060915A (enExample) |
| AU (2) | AU1038802A (enExample) |
| CA (1) | CA2425221A1 (enExample) |
| MX (1) | MXPA03003388A (enExample) |
| WO (1) | WO2002032461A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003232176A1 (en) * | 2002-06-14 | 2003-12-31 | Maxygen Aps | Protein c variants with altered properties |
| WO2004044190A2 (en) * | 2002-11-11 | 2004-05-27 | Maxygen Aps | Zymogen-like protein c polypeptides |
| WO2004113385A1 (en) * | 2003-06-20 | 2004-12-29 | Maxygen Holdings Ltd. | Protein c propeptide variants |
| US9192657B2 (en) | 2003-07-08 | 2015-11-24 | The Scripps Research Institute | Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity |
| WO2005007820A2 (en) * | 2003-07-08 | 2005-01-27 | The Scripps Research Institute | Activated protein c variants with normal cytoprotective activity but reduced anticoagulant activity |
| WO2005042011A1 (en) * | 2003-11-04 | 2005-05-12 | Novo Nordisk A/S | Pharmaceutical composition comprising a protein c polypeptide and a blood glucose regulator |
| JP4707327B2 (ja) * | 2004-01-27 | 2011-06-22 | 旭化成ファーマ株式会社 | ポリペプタイド類の吸着防止剤 |
| WO2006044294A2 (en) * | 2004-10-14 | 2006-04-27 | Eli Lilly And Company | Human protein c analogs |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| DE602007007923D1 (de) * | 2006-04-11 | 2010-09-02 | Csl Behring Gmbh | Verfahren zur erhöhung der in-vivo-gewinnung therapeutischer polypeptide |
| EP3231440A1 (en) | 2006-12-22 | 2017-10-18 | CSL Behring GmbH | Modified coagulation factors with prolonged in vivo half-life |
| EP2242875A4 (en) * | 2008-01-15 | 2012-04-04 | Univ British Columbia | PROTEIN-C-RS2069915 AS RESPONSE PREDICTOR FOR SURVIVAL RATE AND ADMINISTRATION OF AN ACTIVATED PROTEIN-C OR PROTEIN-C-SIMILAR COMPOUND |
| EP2103310A1 (en) * | 2008-03-19 | 2009-09-23 | Universiteit Maastricht | Method for the prevention or treatment of ischemia reperfusion injury. |
| EP2444491B1 (en) | 2008-04-21 | 2016-11-16 | Novo Nordisk Healthcare Ag | Hyperglycosylated human coagulation factor IX |
| WO2010062756A2 (en) * | 2008-11-03 | 2010-06-03 | University Of Rochester | Preventing and treating sepsis |
| WO2012068519A2 (en) | 2010-11-19 | 2012-05-24 | Sirius Genomics Inc. | Markers associated with response to activated protein c administration, and uses thereof |
| CN104394883B (zh) | 2012-07-04 | 2017-05-31 | 悉尼大学 | 炎性皮肤病症的治疗 |
| US20170035862A1 (en) | 2014-04-16 | 2017-02-09 | Zz Biotech Llc | Use of APC analogue for wound healing |
| EP3137102B1 (en) * | 2014-04-16 | 2021-07-14 | ZZ Biotech LLC | Apc for use in the treatment of abnormal cutaneous scarring |
| KR101955884B1 (ko) * | 2017-03-17 | 2019-03-08 | 주식회사 유비프로틴 | 단백질 반감기를 증가시키는 방법 |
| KR101889743B1 (ko) * | 2017-03-17 | 2018-08-20 | 주식회사 유비프로틴 | 단백질 반감기를 증가시키는 방법 |
| KR101893403B1 (ko) * | 2017-03-17 | 2018-08-30 | 주식회사 유비프로틴 | 단백질 반감기를 증가시키는 방법 |
| KR101955886B1 (ko) * | 2017-05-05 | 2019-03-12 | 주식회사 유비프로틴 | 안지오포이에틴-1 반감기를 증가시키는 방법 |
| KR101955885B1 (ko) * | 2017-05-05 | 2019-03-08 | 주식회사 유비프로틴 | Pdgfa 반감기를 증가시키는 방법 |
| KR101947342B1 (ko) * | 2017-05-05 | 2019-02-12 | 주식회사 유비프로틴 | Gm-csf 반감기를 증가시키는 방법 |
| KR101947339B1 (ko) * | 2017-05-05 | 2019-02-12 | 주식회사 유비프로틴 | Pdgfb 반감기를 증가시키는 방법 |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5270040A (en) * | 1985-02-08 | 1993-12-14 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| US5516650A (en) * | 1985-06-27 | 1996-05-14 | Zymogenetics, Inc. | Production of activated protein C |
| US4968626A (en) * | 1985-08-15 | 1990-11-06 | Board Of Reagents Of The University Of Washington | DNA sequence coding for protein C |
| US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
| US4992373A (en) * | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US5196322A (en) * | 1987-12-28 | 1993-03-23 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
| US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
| US5041376A (en) * | 1988-12-09 | 1991-08-20 | The Board Of Regents Of The University Of Texas System | Method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells, the mutant proteins so produced and genes encoding said mutant proteins |
| JP2774154B2 (ja) * | 1989-08-10 | 1998-07-09 | 帝人株式会社 | 活性化ヒトプロテインｃ誘導体 |
| US5225537A (en) * | 1989-12-29 | 1993-07-06 | Zymogenetics, Inc. | Methods for producing hybrid phospholipid-binding proteins |
| US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
| WO1991009960A1 (en) * | 1989-12-29 | 1991-07-11 | Zymogenetics, Inc. | Hybrid protein c |
| IL97311A0 (en) * | 1990-02-23 | 1992-05-25 | Lilly Co Eli | Vectors and compounds for expression of glycosylation mutants of human protein c |
| US5270178A (en) * | 1990-02-23 | 1993-12-14 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
| MY110664A (en) * | 1992-05-21 | 1999-01-30 | Lilly Co Eli | Protein c derivatives |
| JPH0892294A (ja) * | 1994-09-29 | 1996-04-09 | Teijin Ltd | ヒト活性化プロテインｃ誘導体 |
| US5837843A (en) * | 1996-11-08 | 1998-11-17 | Oklahoma Medical Research Foundation | Modified protein C |
| DE69735597T2 (de) * | 1996-11-08 | 2006-12-21 | Oklahoma Medical Research Foundation, Oklahoma | Verwendung eines modifizierten protein-c |
| CA2338799A1 (en) * | 1999-04-30 | 2000-11-09 | Eli Lilly And Company | Protein c derivatives |
| AU2001232799A1 (en) * | 2000-02-11 | 2001-08-20 | Eli Lilly And Company | Protein c derivatives |
-
2001
- 2001-10-15 AU AU1038802A patent/AU1038802A/xx active Pending
- 2001-10-15 CA CA002425221A patent/CA2425221A1/en not_active Abandoned
- 2001-10-15 EP EP01978215A patent/EP1328622A2/en not_active Withdrawn
- 2001-10-15 KR KR10-2003-7005475A patent/KR20030060915A/ko not_active Withdrawn
- 2001-10-15 MX MXPA03003388A patent/MXPA03003388A/es not_active Application Discontinuation
- 2001-10-15 WO PCT/DK2001/000679 patent/WO2002032461A2/en not_active Ceased
- 2001-10-15 JP JP2002535697A patent/JP4071105B2/ja not_active Expired - Fee Related
- 2001-10-15 AU AU2002210388A patent/AU2002210388B2/en not_active Ceased
- 2001-10-17 US US09/978,917 patent/US20030027299A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU1038802A (en) | 2002-04-29 |
| EP1328622A2 (en) | 2003-07-23 |
| WO2002032461A3 (en) | 2002-09-26 |
| KR20030060915A (ko) | 2003-07-16 |
| WO2002032461A2 (en) | 2002-04-25 |
| MXPA03003388A (es) | 2005-03-07 |
| JP4071105B2 (ja) | 2008-04-02 |
| AU2002210388B2 (en) | 2006-11-23 |
| US20030027299A1 (en) | 2003-02-06 |
| JP2004534503A (ja) | 2004-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |