CA2420012A1 - Derives d'erythromycine substitue en 6-o possedant une tolerance gastro-intestinale amelioree - Google Patents

Derives d'erythromycine substitue en 6-o possedant une tolerance gastro-intestinale amelioree Download PDF

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Publication number
CA2420012A1
CA2420012A1 CA002420012A CA2420012A CA2420012A1 CA 2420012 A1 CA2420012 A1 CA 2420012A1 CA 002420012 A CA002420012 A CA 002420012A CA 2420012 A CA2420012 A CA 2420012A CA 2420012 A1 CA2420012 A1 CA 2420012A1
Authority
CA
Canada
Prior art keywords
hydrogen
formula
compound
diyl
isoxazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002420012A
Other languages
English (en)
Inventor
Zhenkun Ma
Ly Tam Phan
Richard F. Clark
Souming Zhang
Stevan Djuric
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2420012A1 publication Critical patent/CA2420012A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I) qui sont utiles dans le traitement des infections bactériennes et permettent d'éviter tout risque concomitant d'intolérance gastro-intestinale. L'invention concerne également des compositions contenant lesdits composés et des méthodes de traitement utilisant ces composés.
CA002420012A 2000-10-16 2001-10-16 Derives d'erythromycine substitue en 6-o possedant une tolerance gastro-intestinale amelioree Abandoned CA2420012A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24077700P 2000-10-16 2000-10-16
US60/240,777 2000-10-16
PCT/US2001/032278 WO2002032919A2 (fr) 2000-10-16 2001-10-16 Derives d'erythromycine substitue en 6-o possedant une tolerance gastro-intestinale amelioree

Publications (1)

Publication Number Publication Date
CA2420012A1 true CA2420012A1 (fr) 2002-04-25

Family

ID=22907903

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002420012A Abandoned CA2420012A1 (fr) 2000-10-16 2001-10-16 Derives d'erythromycine substitue en 6-o possedant une tolerance gastro-intestinale amelioree

Country Status (9)

Country Link
EP (1) EP1328534A2 (fr)
JP (1) JP2004529857A (fr)
AU (1) AU2002213267A1 (fr)
BR (1) BR0109946A (fr)
CA (1) CA2420012A1 (fr)
MX (1) MXPA03003311A (fr)
PE (1) PE20020522A1 (fr)
UY (1) UY26964A1 (fr)
WO (1) WO2002032919A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ533282A (en) 2001-12-05 2006-09-29 Ortho Mcneil Pharm Inc 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials
MXPA04010802A (es) * 2002-04-30 2005-03-07 Abbott Lab Compuestos antibacterianos con perfiles farmacocineticos mejorados.
US6727229B2 (en) * 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
JPWO2004078771A1 (ja) * 2003-03-07 2006-06-08 大正製薬株式会社 ２−フルオロ−６−ｏ−置換ケトライド誘導体
JP2007223900A (ja) * 2004-02-03 2007-09-06 Taisho Pharmaceut Co Ltd ６−ｏ−置換ケトライド誘導体
JP2007254285A (ja) * 2004-03-16 2007-10-04 Taisho Pharmaceut Co Ltd ２−フルオロ−６−ｏ−置換ケトライド誘導体
JP5015016B2 (ja) 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
EP2177526A4 (fr) 2007-08-06 2012-08-22 Taisho Pharmaceutical Co Ltd Composé 10a-azalide réticulé en position 10a et en position 12
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
CN102234302B (zh) * 2010-05-07 2014-05-07 北京理工大学 一种酮内酯衍生物、制备方法及其药物组合物
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity

Also Published As

Publication number Publication date
BR0109946A (pt) 2005-08-02
UY26964A1 (es) 2002-06-20
WO2002032919A3 (fr) 2002-09-19
AU2002213267A1 (en) 2002-04-29
MXPA03003311A (es) 2003-09-10
WO2002032919A2 (fr) 2002-04-25
EP1328534A2 (fr) 2003-07-23
PE20020522A1 (es) 2002-06-25
JP2004529857A (ja) 2004-09-30

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Legal Events

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FZDE Dead