CA2419943A1 - Molecules secretoires - Google Patents
Molecules secretoires Download PDFInfo
- Publication number
- CA2419943A1 CA2419943A1 CA002419943A CA2419943A CA2419943A1 CA 2419943 A1 CA2419943 A1 CA 2419943A1 CA 002419943 A CA002419943 A CA 002419943A CA 2419943 A CA2419943 A CA 2419943A CA 2419943 A1 CA2419943 A1 CA 2419943A1
- Authority
- CA
- Canada
- Prior art keywords
- polynucleotide
- polypeptide
- forwardtm
- seq
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
- 229960002930 sirolimus Drugs 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000010473 stable expression Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000013179 statistical model Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 108060008037 tachykinin Proteins 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 201000005060 thrombophlebitis Diseases 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 208000009999 tuberous sclerosis Diseases 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- HFNHAPQMXICKCF-USJMABIRSA-N urotensin-ii Chemical compound N([C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O HFNHAPQMXICKCF-USJMABIRSA-N 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 201000010044 viral meningitis Diseases 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Cette invention a trait à des polynucléotides sécréteurs purifiés (sptm) et aux polypeptides (SPTM) codés par ceux-ci. Elle concerne également l'utilisation de sptm, ou de compléments, ou d'oligonucléotides, ou de fragments de ces derniers dans des épreuves diagnostiques. L'invention concerne en outre des vecteurs et des cellules hôtes contenant des sptm aux fins de l'expression de SPTM. L'invention concerne aussi l'utilisation de SPTM isolées et purifiées pour induire des anticorps et pour examiner des bibliothèques de composés et l'utilisation d'anticorps anti-SPTM dans des épreuves diagnostiques. L'invention concerne enfin des jeux ordonnés de microéchantillons contenant des sptm et des procédés d'utilisation.
Applications Claiming Priority (57)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23001600P | 2000-09-05 | 2000-09-05 | |
| US22974800P | 2000-09-05 | 2000-09-05 | |
| US22975000P | 2000-09-05 | 2000-09-05 | |
| US22974900P | 2000-09-05 | 2000-09-05 | |
| US22974700P | 2000-09-05 | 2000-09-05 | |
| US23058300P | 2000-09-05 | 2000-09-05 | |
| US22975100P | 2000-09-05 | 2000-09-05 | |
| US60/230,016 | 2000-09-05 | ||
| US60/229,750 | 2000-09-05 | ||
| US60/229,748 | 2000-09-05 | ||
| US60/229,749 | 2000-09-05 | ||
| US60/229,747 | 2000-09-05 | ||
| US60/230,583 | 2000-09-05 | ||
| US60/229,751 | 2000-09-05 | ||
| US23059900P | 2000-09-06 | 2000-09-06 | |
| US23051900P | 2000-09-06 | 2000-09-06 | |
| US23051700P | 2000-09-06 | 2000-09-06 | |
| US23099000P | 2000-09-06 | 2000-09-06 | |
| US23086500P | 2000-09-06 | 2000-09-06 | |
| US23098800P | 2000-09-06 | 2000-09-06 | |
| US23086400P | 2000-09-06 | 2000-09-06 | |
| US23059500P | 2000-09-06 | 2000-09-06 | |
| US23059700P | 2000-09-06 | 2000-09-06 | |
| US23050500P | 2000-09-06 | 2000-09-06 | |
| US23051800P | 2000-09-06 | 2000-09-06 | |
| US23059600P | 2000-09-06 | 2000-09-06 | |
| US23098900P | 2000-09-06 | 2000-09-06 | |
| US23051500P | 2000-09-06 | 2000-09-06 | |
| US23051400P | 2000-09-06 | 2000-09-06 | |
| US23061000P | 2000-09-06 | 2000-09-06 | |
| US60/230,988 | 2000-09-06 | ||
| US60/230,505 | 2000-09-06 | ||
| US60/230,597 | 2000-09-06 | ||
| US60/230,865 | 2000-09-06 | ||
| US60/230,514 | 2000-09-06 | ||
| US60/230,989 | 2000-09-06 | ||
| US60/230,519 | 2000-09-06 | ||
| US60/230,596 | 2000-09-06 | ||
| US60/230,515 | 2000-09-06 | ||
| US60/230,599 | 2000-09-06 | ||
| US60/230,518 | 2000-09-06 | ||
| US60/230,990 | 2000-09-06 | ||
| US60/230,517 | 2000-09-06 | ||
| US60/230,864 | 2000-09-06 | ||
| US60/230,595 | 2000-09-06 | ||
| US60/230,610 | 2000-09-06 | ||
| US23089600P | 2000-09-07 | 2000-09-07 | |
| US23183200P | 2000-09-07 | 2000-09-07 | |
| US23095100P | 2000-09-07 | 2000-09-07 | |
| US23089700P | 2000-09-07 | 2000-09-07 | |
| US23116300P | 2000-09-07 | 2000-09-07 | |
| US60/231,832 | 2000-09-07 | ||
| US60/230,951 | 2000-09-07 | ||
| US60/231,163 | 2000-09-07 | ||
| US60/230,897 | 2000-09-07 | ||
| US60/230,896 | 2000-09-07 | ||
| PCT/US2001/027297 WO2002020756A2 (fr) | 2000-09-05 | 2001-08-30 | Molécules sécrétoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2419943A1 true CA2419943A1 (fr) | 2002-03-14 |
Family
ID=27586833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002419943A Abandoned CA2419943A1 (fr) | 2000-09-05 | 2001-08-30 | Molecules secretoires |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1368375A2 (fr) |
| AU (1) | AU2001287022A1 (fr) |
| CA (1) | CA2419943A1 (fr) |
| WO (1) | WO2002020756A2 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2281437T3 (es) | 2000-08-22 | 2007-10-01 | Agensys, Inc. | Acido nucleico y proteina correspondiente denominada 158p1d7 util para el tratamiento y la deteccion del cancer de vejiga y otros canceres. |
| US7358353B2 (en) | 2000-08-22 | 2008-04-15 | Agensys, Inc. | Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers |
| GB0027905D0 (en) * | 2000-11-15 | 2000-12-27 | Glaxo Group Ltd | New protein |
| WO2003072723A2 (fr) * | 2002-02-22 | 2003-09-04 | Incyte Corporation | Molecules de signalisation intracellulaire |
| AU2003237367A1 (en) | 2002-06-03 | 2003-12-19 | Chiron Corporation | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer |
| JP2004267015A (ja) * | 2003-03-05 | 2004-09-30 | National Institute Of Advanced Industrial & Technology | 核酸及び該核酸を用いた癌化検定方法 |
| TR201900694T4 (tr) | 2012-08-23 | 2019-02-21 | Agensys Inc | 158p1d7 proteinlerine bağlanan antikor ilaç konjugatları (adc). |
| CN110850088B (zh) * | 2019-12-06 | 2021-08-20 | 四川大学华西医院 | Gtf2ird2自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| WO2024076801A2 (fr) * | 2022-08-09 | 2024-04-11 | Wisconsin Alumni Research Foundation | Nouveaux auto-anticorps et procédé pour détecter la maladie de sjögren |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001521383A (ja) * | 1997-04-08 | 2001-11-06 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | ２０個のヒト分泌タンパク質 |
| AU2001236631A1 (en) * | 2000-02-24 | 2001-09-03 | Incyte Genomics, Inc. | Secretory molecules |
-
2001
- 2001-08-30 CA CA002419943A patent/CA2419943A1/fr not_active Abandoned
- 2001-08-30 AU AU2001287022A patent/AU2001287022A1/en not_active Abandoned
- 2001-08-30 EP EP01966516A patent/EP1368375A2/fr not_active Withdrawn
- 2001-08-30 WO PCT/US2001/027297 patent/WO2002020756A2/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002020756A3 (fr) | 2003-08-28 |
| WO2002020756A2 (fr) | 2002-03-14 |
| EP1368375A2 (fr) | 2003-12-10 |
| AU2001287022A1 (en) | 2002-03-22 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Dead |