CA2419943A1 - Secretory molecules - Google Patents

Abstract

The present invention provides purified secretory polynucleotides (sptm) and the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.

Description

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SECRETORY MOLECULES
TECHNICAL FIELD
The present invention relates to secretory molecules and to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, the expression of secretory molecules.
to BACKGROUND OF THE INVENTION
Protein transport and secretion are essential for cellular function. Protein transport is mediated by a signal peptide located at the amino terminus of the protein to be transported or secreted.
The signal peptide is comprised of about ten to twenty hydrophobic amino acids which target the nascent protein from the ribosome to a particular membrane bound compartment such as the 15 endoplasmic reticulum (ER). Proteins targeted to the ER may either proceed through the secretory pathway or remain in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes.
Proteins that transit through the secretory pathway are either secreted into the extracellular space or retained in the plasma membrane. Proteins that are retained in the plasma membrane contain one or more transmembrane domains each comprised of about 20 hydrophobic amino acid residues. Proteins ~ o that are secreted from the cell are generally synthesized as inactive precursors that are activated by post-translational processing events during transit through the secretory pathway. Such events include glycosylation, proteolysis, and removal of the signal peptide by a signal peptidase. Other events that may occur during protein transport include chaperone-dependent unfolding and folding of the nascent protein and interaction of the protein with a receptor or pore complex.
Examples of secretory proteins 25 With amino terminal signal peptides are discussed below and include proteins with important roles in cell-to-cell signaling. Such proteins include transmembrane receptors and cell surface markers, extracellular matrix molecules, cytokines, hormones, growth and differentiation factors, neuropeptides, vasomediators, ion channels, transporterslpumps, and proteases. (Reviewed in Alberts, B. et al.
(1994) Molecular Biolo~y of The Cell, Garland Publishing, New York NY, pp. 557-560, 582-592.) 3 o G-protein coupled receptors (GPCRs) comprise a superfamily of integral membrane proteins which transduce extracellular signals. Not all GPCRs contain N-terminal signal peptides. GPCRs include receptors for biogenic amines such as dopamine, epinephrine, histamine, glutamate (metabotropic-type), acetylcholine (muscarinic-type), and serotonin; for lipid mediators of inflammation such as prostaglandins, platelet activating factor, and leukotrienes; for peptide hormones such as calcitonin, CSa anaphylatoxin, follicle stimulating hormone, gonadotropin releasing hormone, neurokinin, oxytocin, and thrombin; and for sensory signal mediators such as retinal photopigments and olfactory stimulatory molecules. The structure of these highly conserved receptors consists of seven hydrophobic transmembrane regions, cysteine disulfide bridges between the second and third s extracellular loops, an extracellular N-terminus, and a cytoplasmic C-terminus. The N-terminus interacts with ligands, the disulfide bridges interact with agonists and antagonists, and the large third intracellular loop interacts with G proteins to activate second messengers such as cyclic AMP, phospholipase C, inositol triphosphate, or ion channels. (Reviewed in Watson, S. and Arkinstall, S.
(1994) The G protein Linked Receptor Facts Book, Academic Press, San Diego CA, pp. 2-6; and to Bolander, F.F. (1994) Molecular Endocrinolo~y, Academic Press, San Diego CA, pp. 162-176.) Other types of receptors include cell. surface antigens identified on leukocytic cells of the immune system. These antigens have been identified using systematic, monoclonal antibody (mAb)-based "shot gun" techniques. These techniques have resulted in the production of hundreds of mAbs directed against unknown cell surface leukocytic antigens. These antigens have been grouped into 15 "clusters of differentiation" based on common immunocytochemical,localization patterns in various differentiated and undifferentiated leukocytic cell types. Antigens in a given cluster are presumed to identify a single cell surface protein and are assigned a "cluster of differentiation" or "CD"
designation. Some of the genes encoding proteins identified by CD antigens have been cloned and verified by standard molecular biology techniques. CD antigens have been characterized as both 2 0 transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing.glycolipids such as glycosylphosphatidylinositol (GPI). (Reviewed in Barclay, A.N. et al. (1995) The Leucocvte Antigen Facts Book, Academic Press, San Diego CA, pP. 17-20.) Matrix proteins (MPs) are transmembrane and extracellular proteins which function in 2 s formation, growth, remodeling, and maintenance of tissues and as important mediators and regulators of the inflammatory response. The expression, and balance of MPs may be perturbed by biochemical changes that result from congenital, epigenetic, or infectious diseases. In addition, MPs affect leukocyte migration, proliferation, differentiation, and activation in the immune response. MPs are frequently characterized by the presence of one or more domains which may include collagen-like s o domains, EGF-like domains, immunoglobulin-like domains, and fibronectin-like domains. In addition, MPs may be heavily glycosylated and may contain an Arginine-Glycine-Aspartate (RGD) tripeptide motif which may play a role in adhesive interactions. MPs include extracellular proteins such as fibronectin, collagen, galectin, vitronectin and its proteolytic derivative somatomedin B; and cell adhesion receptors such as cell adhesion molecules (CAMs), cadherins, and integrins. (Reviewed in Ayad, S. et al. (1994) The Extracellular Matrix Facts Book, Academic Press, San Diego CA, pp. 2-16; Ruoslahti, E. (1997) Kidney Int. 51:1413-1417; Sjaastad, M.D. and Nelson, W.J. (1997) BioEssays 19:47-55.) ' s Cytokines are secreted by hematopoietic cells in response to injury or infection. Interleukins, neurotrophins, growth factors, interferons, and chemokines all define cytokine families that work in conjunction with cellular receptors to regulate cell proliferation and differentiation. In addition, cytokines effect activities such as leukocyte migration and function, hematopoietic cell proliferation, temperature regulation, acute response to infection, tissue remodeling, and apoptosis.
to Chemokines, in particular, are small chemoattractant cytokines involved in inflammation, leukocyte proliferation and migration, angiogenesis and angiostasis, regulation of hematopoiesis, HIV
infectivity, and stimulation of cytokine secretion. Chemokines generally contain 70-100 amino acids and are subdivided into four subfamilies based on the presence of conserved cysteine-based motifs.
(Callard, R. and Gearing, A. (1994) The Cytokine Facts Book, Academic Press, New York NY, pp.
is 181-190, 210-213, 223-227.) Growth and differentiation factors are secreted proteins which function in intercellular communication. Some factors require oligomerization or association with MPs for activity. Complex interactions among these factors and their receptors trigger intracellular signal transduction pathways that stimulate or inhibit cell division, cell differentiation, cell signaling, and cell motility. Most growth ~ o and differentiation factors. act on cells in their local environment (paracrine signaling). There are three broad classes of growth and differentiation factors. The first class includes the large polypeptide growth factors such as epidermal growth factor, fibroblast growth factor, transforming growth factor, insulin-like growth factor, and platelet-derived growth factor. The second class includes the hematopoietic growth factors such as the colony stimulating factors (CSFs).
Hematopoietic growth 25 factors stimulate the proliferation and differentiation of blood cells such as B-lymphocytes, T-lymphocytes, erythrocytes, platelets, eosinophils, basophils~ neutrophils, macrophages, and their stem.
cell precursors. The third class includes small peptide factors such as bombesin, vasopressin, oxytocin, endothelin, transferrin, angiotensin II, vasoactive intestinal peptide, and bradykinin which function as hormones to regulate cellular functions other than proliferation.

3 o Growth and differentiation factors play critical roles in neoplastic transformation of cells in vitro and in tumor progression in vivo. Inappropriate expression of growth factors by tumor cells may contribute to vascularization and metastasis of tumors. During hematopoiesis, growth factor misregulation can result in anemias, leukemias, and lymphomas. Certain growth factors such as interferon are cytotoxic to tumor cells both in vivo and in vitro. Moreover, some growth factors and growth factor receptors are related both structurally and functionally to oncoproteins. In addition, growth factors affect transcriptional regulation of both proto-oncogenes and oncosuppressor genes.
(Reviewed in Pimentel, E. (1994) Handbook of Growth Factors, CRC Press, Ann Arbor MI, pp. 1-9.) s Proteolytic enzymes or proteases either activate or deactivate proteins by hydrolyzing peptide bonds. Proteases are found in the cytosol, in membrane-bound compartments, and in the extracellular space. The major families are the zinc, serine, cysteine, thiol, and carboxyl proteases.
Ion channels, ion pumps, and transport proteins mediate the transport of molecules across cellular membranes. Transport can occur by a passive, concentration-dependent mechanism or can to be linked to an energy source such as ATP hydrolysis. Symporters and antiporters transport ions and small molecules such as amino acids, glucose, and drugs. Symporters transport molecules and ions unidirectionally, and antiporters transport molecules and ions bidirectionally. Transporter superfamilies include facilitative transporters and active ATP-binding cassette transporters which are involved in multiple-drug resistance and the targeting of antigenic peptides to MHC Class I molecules. These 15 transporters bind to a specific ion or other molecule and undergo a conformational change in order to transfer the ion or molecule across the membrane. (Reviewed in Alberts, B. et al. (1994) Molecular Biolo~y of The Cell, Garland,Publishing, New York NY, pp. 523-546.) Ion channels are foimed by transmembrane proteins which create a lined passageway across the membrane through which water and ions, such as Na+, K+, Ca2+, and Cf, enter and exit the cell.
a o For example, chloride channels are involved in the regulation of the membrane electric potential as . .
well as absorption and secretion of ions across the membrane. Chloride channels also regulate the internal pH of membrane-bound organelles.
Ion pumps are ATPases which actively maintain membrane gradients. Ion pumps are classified as P, V, or F according to their structure and function. All have one or more binding sites 25 for ATP in their cytosolic domains. The P-class ion pumps include Ca2+
ATPase and Na+/K+ ATPase and function in transporting H+, Na+, K+, and Ca2+ ions. P-class pumps consist of two a and two (3 transmembrane subunits; The V- and F-class ion pumps have similar structures but transport only H+.
F class H+ pumps mediate transport across the membranes of mitochondria and chloroplasts, while V-class H+ pumps regulate acidity inside lysosomes, endosomes, and plant vacuoles.
s o A family of structurally related intrinsic membrane proteins known as facilitative glucose transporters catalyze the movement of glucose and other selected sugars across the plasma membrane. The proteins in this family contain a highly conserved, large transmembrane domain comprised of 12 a-helices, and several weakly conserved, cytoplasmic and exoplasmic domains.

(Pessin, J.E. and Bell, G.I. (1992) Annu. Rev. Physiol. 54:911-930.) Amino acid transport is mediated by Na+ dependent amino acid transporters.
These transporters are involved in gastrointestinal and renal uptake of dietary and cellular amino acids and in neuronal reuptake of neurotransmitters. Transport of cationic amino acids is mediated by the system s y+ family and the cationic amino acid transporter (CAT) family. Members of the CAT family share a high degree of sequence homology, and each contains 12-14 putative transmembrane domains. (Ito, K. and Groudine, M. (1997) J. Biol. Chem. 272:26780-26786.) Hormones are secreted molecules that travel through the circulation and bind to specific receptors on the surface of, or within, target cells. Although they have diverse biochemical to compositions and mechanisms of action, hormones can be grouped into two categories. One category includes small lipophilic hormones that diffuse through the plasma membrane of target cells, bind to cytosolic or nuclear receptors, and form a complex that alters gene expression. Examples of these molecules include retinoic acid, thyroxine, and the cholesterol-derived steroid hormones such as progesterone, estrogen, testosterone, cortisol, and aldosterone. The second category includes is hydrophilic hormones that function by binding to cell surface receptors that transduce signals across the plasma membrane. Examples of such hormones include amino acid derivatives such as catecholamines and peptide hormones such as glucagon, insulin, gastrin, secretin, cholecystokinin, adrenocorticotropic hormone, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, and vasopressin. (See, for example, Lodish et al. (1995) Molecular Cell Biology, Scientific, 2 o American Books Inc., New York NY, pp. 856-864.) Neuropeptides and vasomediators (NP/VM) comprise a large family of endogenous signaling molecules. Included in this family are neuropeptides and neuropeptide hormones such as bombesin, neuropeptide Y, neurotensin, neuromedin N, melanocortins, opioids, galanin, somatostatin, tachykinins, urotensin II and related peptides involved in smooth muscle stimulation, vasopressin, vasoactive a s intestinal peptide, and circulatory system-borne signaling molecules such as angiotensin, complement, calcitonin, endothelins, formyl-methionyl peptides, glucagon, cholecystokinin and gastrin. NP/VMs can transduce signals directly, modulate the activity or release of other neurotransmitters and hormones, and act as catalytic enzymes in cascades. The effects of NP/VMs range from extremely brief to long-lasting. (Reviewed in Martin, C.R. et al. (1985) Endocrine Physioloey, Oxford University Press, 3 o New York, NY, pp. 57-62.) The discovery of new secretory molecules satisfies a need in the art by providing new compositions which are useful in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, cell signaling and the expression of secretory molecules.
SUMMARY OF THE INVENTION
The present invention relates to nucleic acid sequences comprising human polynucleotides s encoding secretory polypeptides that contain signal peptides andlor transmembrane domains. These human polynucleotides (sptm) as presented in the Sequence Listing uniquely identify partial or full length genes encoding structural, functional, and regulatory polypeptides involved in cell signaling.
The invention provides an isolated polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID
to N0:1-184; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90%
identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-184; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In one alternative, the polynucleotide comprises a polynucleotide sequence selected from the group consisting of SEQ
1D NO:1-184. In is another alternative, the polynucleotide comprises at least 30 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-184; b) a polynucleotide comprising a naturally occurring polynucleotide comprising a polynucleotide sequence at least 90%
identical to a polynucleotide sequence'selected~from the group consisting of SEQ III NO:1-184; c) a polyriucleotide .
2 o complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In another alternative, the polynucleotide comprises at least 60 contiguous nucleotides.of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID
NO:l-184; b) a polynucleotide comprising a naturally occurring polynucleotide comprising a 25 polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ~ NO:1-184; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA
equivalent of a) through d).
The invention further provides a composition for the detection of expression of secretory polynucleotides comprising at least one isolated polynucleotide comprising a polynucleotide selected s o from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-184; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-184; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA
equivalent of a) through d);
and a detectable label.
The invention also provides a method for detecting a target polynucleotide in a sample, said target polynucleotide having a polynucleotide sequence of a polyneucleotide selected from the group s consisting of a) a polynucleotide comprising a polynucleotide sequence of a polynucleotide selected from the group consisting of SEQ ID N0:1-184; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-184; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA
equivalent of a) through d).
to The method comprises a) amplifying said target polynucleotide or fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof.
The invention also provides a method for detecting a target polynucleotide in a sample, said target polynucleotide having a polynucleotide sequence of a polynucleotide selected from the group is consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-184; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-184; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). The method.
2o comprises a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample; and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide, and b) detecting the presence or absence of said hybridization complex, and, optionally, if present, the amount thereof. In one alternative, the 2 s invention provides a composition comprising a target polynucleotide of the method, wherein said probe comprises at least 30 contiguous nucleotides. In one alternative, the invention provides a composition comprising a target polynucleotide of the method, wherein said probe comprises at least 60 contiguous nucleotides.
The invention further provides a recombinant polynucleotide comprising a promoter sequence 3 0 operably linked to an isolated polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ
ID N0:1-184; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-184;
c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA equivalent of a) through d). In one alternative, the invention provides a cell transformed with the recombinant polynucleotide. In another alternative, the invention provides a transgenic organism comprising the recombinant polynucleotide.
The invention also provides a method for producing a secretory polypeptide, the method comprising a) culturing a cell under conditions suitable for expression of the secretory polypeptide, wherein said cell is transformed with a recombinant polynucleotide, said recombinant polynucleotide comprising an isolated polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ
ID N0:1-184; ii) a so polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-184;
iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv), and b) recovering the secretory polypeptide so expressed. The invention additionally provides a method wherein the polypeptide has an amino acid , is sequence selected from the group consisting of SEQ ID N0:185-369.
The invention also provides an isolated secretory polypeptide (SPTM) encoded by at least one polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ~ID
NO:1-184. The invention further provides a method of screening for a test compound that specifically binds to the polypeptide having an amino acid sequence selected from the group consisting of SEQ ID
a o N0:185-369. The method comprises a) combining the polypeptide having an amino acid sequence=, selected from the group consisting of SEQ ID N0:185-369 with at least one test compound under suitable conditions, and b) detecting binding of the polypeptide having an amino acid sequence selected from the group consisting of.SEQ ID N0:185-369 to the test compound, thereby identifying a compound that specifically binds to the polypeptide having an amino acid sequence selected from the 25 group consisting of SEQ ID N0:185-369.
The invention further provides a microarray wherein at least one element of the microarray is an isolated polynucleotide comprising at least 30 contiguous nucleotides of a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-184; b) a polynucleotide comprising a naturally occurnng s o polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ E3 N0:1-184; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA
equivalent of a) through d).
The invention also provides a method for generating a transcript image of a sample which contains polynucleotides. The method comprises a) labeling the polynucleotides of the sample, b) contacting the elements of the microarray with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample.
s Additionally, the invention provides a method for screening a compound for effectiveness in altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide selected from the group consisting of a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-184; b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence so selected from the group consisting of SEQ ID NO:1-184; c) a polynucleotide complementary to the polynucleotide of a); d) a polynucleotide complementary to the polynucleotide of b); and e) an RNA
equivalent of a) through d). The method comprises a) exposing a sample comprising the target polynucleotide to a compound, b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the is compound and in the absence of the compound.
The invention further provides a method for assessing toxicity of a test compound, said method comprising a) treating a biological sample containing nucleic acids with the test compound; b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide selected from the group consisting of i) a polynucleotide 2 o comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-184; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ff~ NO:1-184; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv). . Hybridization occurs under conditions whereby a 25 specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence of a polynucleotide selected from the group consisting of i) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ )D NO:1-184; ii) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from s o the group consisting of SEQ ID NO:1-184; iii) a polynucleotide complementary to the polynucleotide of i); iv) a polynucleotide complementary to the polynucleotide of ii); and v) an RNA equivalent of i) through iv), and alternatively, the target polynucleotide comprises a polynucleotide sequence of a fragment of a polynucleotide selected from the group consisting of i-v above;
c) quantifying the amount of hybridization complex; and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound.
The invention further provides an isolated polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID
N0:185-369, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90%
identical to an amino acid sequence selected from the group consisting of SEQ
ID NO:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group to consisting of SEQ ID N0:185-369, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from.the group consisting of SEQ ID N0:185-369. In one alternative, the invention provides an isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ 1D N0:185-369.
The invention further provides an isolated polynucleotide encoding a polypeptide selected from 15 the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ 1D N0:185-369, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ.
ID N0:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ff~ N0:185-369, and d) an immunogenic fragment of a 2 o polypeptide having an amino acid sequence selected from the group consisting of SEQ ID N0:185-369. In one alternative, the polynucleotide encodes a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID N0:185-369. In another alternative, the polynucleotide comprises a polynucleotide sequence selected from the group consisting of SEQ
ID NO:1-184.
Additionally, the invention provides an isolated antibody which specifically binds to a 2s polypeptide selected from the group consisting of a) apolypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:185-369, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID N0:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID N0:185-369, and d) an s o immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID N0:185-369.
The invention further provides a composition comprising a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting to of SEQ ID N0:185-369, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ 1D N0:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ 1D N0:185-369, and d) an immunogenic fragment of a polypeptide having s an amino acid sequence selected from the group consisting of SEQ ID NO 185-369, and a pharmaceutically acceptable excipient. In one embodiment, the composition comprises a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID
N0:185-369. The invention additionally provides a method of treating a disease or condition associated with decreased expression of functional SPTM, comprising administering to a patient in need of such treatment the to composition.
The invention also provides a method for screening a compound for effectiveness as an agonist of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID N0:185-369, b) a polypeptide comprising a naturally occurring amino acid sequence at least ~90% identical to an amino acid sequence selected 15 from the group consisting of SEQ ID N0:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID
N0:185;369~ and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369. The method comprises a) exposing a sample comprising the polypeptide to a compound, and b) detecting agonist activity in the sample. In one alternative, the 2 o invention provides a composition comprising an agonist compound identified by the method and a pharmaceutically acceptable excipient. In another alternative, the invention provides a method of treating a disease or condition associated with 'decreased expression of functional SPTM, comprising administering to a patient in need of such treatment the composition.
Additionally, the invention provides a method for screening a compound for effectiveness as a s an antagonist of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID N0:185-369 b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ )D N0:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID
s o NO:l 85-369, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ 11~ N0:185-369. The method comprises a) exposing a sample comprising the polypeptide to a compound, and b) detecting antagonist activity in the sample.
In one alternative, the invention provides a composition comprising an antagonist compound identified by the method and a pharmaceutically acceptable excipient. In another alternative, the invention provides a method of treating a disease or condition associated with overexpression of functional SPTM, comprising administering to a patient in need of such treatment the composition.
The invention further provides a method of screening for a compound that modulates the s activity of a polypeptide selected from the group consisting of a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID N0:185-369, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO
185-369, and d) an to immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID N0:185-369. The method comprises a) combining the polypeptide with at least one test compound under conditions permissive for the activity of the polypeptide, b) assessing the activity of the polypeptide in the presence of the test compound, and c) comparing the activity of the polypeptide in the presence of the test compound with the activity of the polypeptide in the absence of 15 the test compound, wherein a change in the activity of the polypeptide in the presence of the test compound is indicative of a compound that modulates the activity of the polypeptide.
DESCRIPTION OF THE 'TABLES
Table 1 shows the sequence identification numbers (SEQ ID NOa) and template identification 2 o numbers (template mss) corresponding to the polynucleotides of the present invention, along with they.
sequence identification numbers (SEQ ID NOa) and open reading frame identification numbers (ORF
IDs) corresponding to polypeptides encoded by the template ID.
Table 2 shows the sequence identification numbers (SEQ ID NOa) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with 2 s polynucleotide segments of each template sequence as defined by the indicated "start" and "stop"
nucleotide positions. The reading frames of the polynucleotide segments are shown, and the polypeptides encoded by the polynucleotide segments constitute either signal peptide (SP) or transmembrane (TM) domains, as indicated. The membrane topology of the encoded polypeptide sequence is indicated, the N-terminus (N) listed as being oriented to either the cytosolic (N in) or non-s o cytosolic (N out) side of the cell membrane or organelle.
Table 3 shows the sequence identification numbers (SEQ ID NOa) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with component sequence identification numbers (component IDs) corresponding to each template. The component sequences, which were used to assemble the template sequences, are defined by the indicated "start" and "stop" nucleotide positions along each template.
Table 4 shows the tissue distribution profiles for the templates of the invention.
Table 5 shows the sequence identification numbers (SEQ ID NOa) corresponding to the s polypeptides of the present invention, along with the reading frames used to obtain the polypeptide segments, the lengths of the polypeptide segments, the "start" and "stop"
nucleotide positions of the polynucleotide sequences used to define the encoded polypeptide segments, the GenBank hits (GI
Numbers), probability scores, and functional annotations corresponding to the GenBank hits.
Table 6 summarizes the bioinformatics tools which are useful for analysis of the so polynucleotides of the present invention. The first column of Table 6 lists analytical tools, programs, and algorithms, the second column provides brief descriptions thereof, the third column presents appropriate references, all of which are incorporated by reference herein in their entirety, and the fourth column presents, where applicable, the scores, probability values, and other parameters used to evaluate the strength of a match between two sequences (the higher the score, the greater the is homology between two sequences).
DETAILED DESCRIPTION OF THE INVENTION
Before the nucleic acid sequences and methods are presented, it is to be understood that this invention is not limited to the particular machines, methods, and materials described. Although 2 o particular embodiments are described, machines, methods, and materials similar or equivalent to these embodiments may be used to practice the invention. The preferred machines, methods, and materials set forth are not intended to limit the scope of the invention which is limited only by the appended claims.
The singular forms "a", "an", and "the" include plural reference unless the context clearly 25 dictates otherwise. All technical and scientific terms have the meanings commonly understood by one of ordinary skill in the art. All publications are incorporated by reference for the purpose of describing and disclosing the cell lines, vectors, and methodologies which are presented and which might be used in connection with the invention. Nothing in the specification is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention.
Definitions As used herein, the lower case "sptm" refers to a nucleic acid sequence, while the upper case "SPTM" refers to an amino acid sequence encoded by sptm. A "full-length" sptm refers to a nucleic acid sequence containing the entire coding region of a gene endogenously expressed in human tissue.
"Adjuvants" are materials such as Freund's adjuvant, mineral gels (aluminum hydroxide), and surface active substances (lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, and dinitrophenol) which may be administered to increase a host's immunological s ~ response.
"Allele" refers to an alternative form of a nucleic acid sequence. Alleles result from a "mutation," a change or an alternative reading of the genetic code. Any given gene may have none, one, or many allelic forms. Mutations which give rise to alleles include deletions, additions, or substitutions of nucleotides. Each of these changes may occur alone, or in combination with the so others, one or more times in a given nucleic acid sequence. The present invention encompasses allelic sptm "Amino acid sequence" refers to a peptide, a polypeptide, or a protein of either natural or synthetic origin. The amino acid sequence is not limited to the complete, endogenous amino acid sequence and may be a fragment, epitope, variant, or derivative of a protein expressed by a nucleic is acid sequence.
"Amplification" refers to the production of additional copies of a sequence and is earned out.
using polymerase chain reaction (PCR) technologies well known in the art.
"Antibody" refers to intact molecules as well as to fragments thereof, such as Fab, F(ab')2, and Fv fragments, which are capable of binding the epitopic determinant.
Antibodies that bind SPTM
2 o polypeptides can be prepared using intact polypeptides or using fragments containing small peptides of interest as the immunizing antigen. The polypeptide or peptide used to immunize an animal (e:g., a mouse, a rat, or a rabbit) can be derived from the translation of RNA, or synthesized chemically, and can be conjugated to a'carrier protein if desired. Commonly used carriers that are chemically coupled to peptides include bovine serum albumin, thyroglobulin, and keyhole limpet hemocyanin (KLI~. The 2 s coupled peptide is then used to immunize the animal.
"Antisense sequence" refers to a sequence capable of specifically hybridizing to a target sequence. ,The antisense sequence may include DNA, RNA, or any nucleic acid mimic or analog such as peptide nucleic acid (PNA); oligonucleotides having modified backbone linkages such as phosphorothioates, methylphosphonates, or benzylphosphonates; oligonucleotides having modified s o sugar groups such as 2'-methoxyethyl sugars or 2'-methoxyethoxy sugars; or oligonucleotides having modified bases such as 5-methyl cytosine, 2'-deoxyuracil, or 7-deaza-2'-deoxyguanosine.
"Antisense sequence" refers to a sequence capable of specifically hybridizing to a target sequence. The antisense sequence can be DNA, RNA, or any nucleic acid mimic or analog.

l "Antisense technology" refers to any technology which relies on the specific hybridization of an antisense sequence to a target sequence.
A "bin" is a portion of computer memory space used by a computer program for storage of data, and bounded in such a manner that data stored in a bin may be retrieved by the program.
s "Biologically active" refers to an amino acid sequence having a structural, regulatory, or biochemical function of a naturally occurring amino acid sequence.
"Clone joining" is a process for combining gene bins based upon the bins' containing sequence information from the same clone. The sequences may assemble into a primary gene transcript as well as one or more splice variants.
to "Complementary" describes the relationship between two single-stranded nucleic acid sequences that anneal by base-pairing (5'-A-G-T-3' pairs with its complement 3'-T-C-A-5').
A "component sequence" is a nucleic acid sequence selected by a computer program such as PHRED and used to assemble a consensus or template sequence from one or more component sequences.
15 A "consensus sequence" or "template sequence" is a nucleic acid sequence which has been . assembled from overlapping sequences, using a computer program for fragment assembly such as the GELVIEW fragment assembly system (Genetics Computer Group (GCG), Madison WI) or using a relational database rrianagement system (RDMS).
"Conservative amino acid substitutions" are those substitutions that, when made, least a o .interfere with the properties of the original protein, i.e., the structure and especially the function of the protein is conserved and not significantly changed by such substitutions. The table below shows amino acids which may be substituted for an original amino acid in a protein and which are regarded as conservative substitutions.
25 Original Residue Conservative Substitution Ala Gly, Ser Arg His, Lys Asn Asp, Gln, His Asp Asn, Glu 3 o Cys Ala, Ser Gln Asn, Glu, His Glu Asp, Gln, His Gly Ala ' His Asn, Arg, Gln, Glu 3 5 Ile Leu, Val Leu Ile, Val Lys Arg, Gln, Glu Met Leu, Ile Phe His, Met, Leu, Trp, Tyr Ser Cys, Thr 'Thr Ser, Val s Trp Phe, Tyr Tyr His, Phe, Trp Val Ile, L,eu, Thr to Conservative substitutions generally maintain (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a beta sheet or alpha helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain.
"Deletion" refers to a change in either a nucleic or amino acid sequence in which at least one nucleotide or amino acid residue, respectively, is absent.
is "Derivative" refers to the chemical modification of a nucleic acid sequence, such as by replacement of hydrogen by an alkyl, acyl, amino, hydroXyl, or other group.
"Differential expression" refers to increased or upregulated; or decreased, downregulated, or absent gene ox protein expression, determined by comparing at least two different samples. Such comparisons may be carried out between, for example, a treated and an untreated sample, or a 2 o diseased and a normal sample.
The terms "element" and "array element" refer to a polynucleotide, polypeptide, or other chemical compound having a unique and defined position on a microarray.
"E-value" refers to the statistical probability that a match between two sequences occurred by.
chance.
25 "Exon shuffling" refers to the recombination of different coding regions (exons). Since an exon may represent a structural or functional domain of the encoded protein, new proteins may be assembled through the novel reassortment of stable substructures, thus allowing acceleration of the evolution of new protein functions.
A "fragment" is a unique portion of sptm or SPTM which is identical in sequence to but 3 o shorter in length than the parent sequence. A fragment may comprise up to the entire length of the defined sequence, minus one nucleotide/amino acid residue. For example, a fragment may comprise from 10 to 1000 contiguous amino acid residues or nucleotides. A fragment used as a probe, primer, antigen, therapeutic molecule, or for other purposes, may be at least 5, 10, 15, 16, 20, 25, 30, 40, 50, 60, 75, 100, 150, 250 or at least S00 contiguous amino acid residues or nucleotides in length. Fragments 35 may be preferentially selected from certain regions of a molecule. For example, a polypeptide fragment may comprise a certain length of.contiguous amino acids selected from the first 250 or 500 amino acids (or first 25% or 50%) of a polypeptide as shown in a certain defined sequence. Clearly these lengths are exemplary, and any length that is supported by the specification, including the Sequence Listing and the figures, may be encompassed by the present embodiments.
A fragment of sptm comprises a region of unique polynucleotide sequence that specifically s identifies sptm, for example, as distinct from any other sequence in the same genome. A fragment of sptm is useful, for example, in hybridization and amplification technologies and in analogous methods that distinguish sptm from related polynucleotide sequences. The precise length of a fragment of sptm and the region of sptm to which the fragment corresponds are routinely determinable by one of ordinary skill in the ait based on the intended purpose for the fragment.
to A fragment of SPTM is encoded by a fragment of sptm. A fragment of SPTM
comprises a region of unique amino acid sequence that specifically identifies SPTM. For example, a fragment of SPTM is useful as an immunogenic peptide for the development of antibodies that specifically recognize SPTM. The precise length of a fragment of SPTM and the region of SPTM to which the fragment corresponds are routinely determinable by one of ordinary skill in the art based on the is intended purpose for the fragment.
A "full length" nucleotide sequence is one containing at least a start site for translation to a protein sequence, followed liy an open reading frame and a stop site, and encoding a "full length"
polypeptide.
"Hit" refers to a sequence whose annotation will be used to describe a given template.
~ o Criteria for selecting the top hit are as follows: if the template has one or more exact nucleic acid matches, the top hit is the exact match with highest percent identity. If the template has no exact matches but has significant protein hits, the top hit is the protein hit with the lowest E-value. If the template has no significant protein hits, but does have significant non-exact nucleotide hits, the top hit is the nucleotide hit with the lowest E-value.
2 s "Homology" refers to sequence similarity either between a reference nucleic acid sequence and at least a fragment of an sptm or between a reference amino acid sequence and a fragment of an SPTM.
"Hybridization" refers to the process by which a strand of nucleotides anneals with a complementary strand through base pairing. Specific hybridization is an indication that two nucleic s o acid sequences share a high degree of identity. Specific hybridization complexes form under defined annealing conditions, and remain hybridized after the "washing" step. The defined hybridization conditions include the annealing conditions and the washing step(s), the latter of which is particularly important in determining the stringency of the hybridization process, with more stringent conditions allowing less non-specific binding, i.e., binding between pairs of nucleic acid probes that are not perfectly matched. Permissive conditions for annealing of nucleic acid sequences are routinely determinable and may be consistent among hybridization experiments, whereas wash conditions may be varied among experiments to achieve the desired stringency.
s Generally, stringency of hybridization is expressed with reference to the temperature under which the wash step is carried out. Generally, such wash temperatures are selected to be about 5°C
to 20°C lower than the thermal melting point (T"~ for the specific sequence at a defined ionic strength and pH. The Tm is the temperature (under defined ionic strength and pH) at which 50% of the target sequence hybridizes to a perfectly matched probe. An equation for calculating Tm and conditions for to nucleic acid hybridization is well known and can be found in Sambrook et al., 1989, Molecular Cloning:
A Laborator~Manual, 2°d ed., vol. 1-3, Cold Spring Harbor Press, Plainview NY; specifically see volume 2, chapter 9.
High stringency conditions for hybridization between polynucleotides of the present invention include wash conditions of 68°C in the presence of about 0.2 x SSC and about 0.1 % SDS, for 1. hour.
15 Alternatively, temperatures of about 65°C, 60°C, or 55°C may be used. SSC concentration may be varied from about 0.2 to 2 x SSC, with SDS being present at about 0.1 %.
Typically, blocking reagents are used to block non-specific hybridization. Such blocking reagents include, for instance, denatured salmon sperm DNA at about 100-200 ~g/ml. Useful variations on these conditions will be readily .
apparent to those skilled in the art. Hybridization, particularly under high stringency conditions, may be 2 o suggestive of evolutionary similarity between the nucleotides. Such similarity is strongly indicative of a similar role for the nucleotides and their resultant proteins:
Other parameters, such as temperature, salt concentration, and detergent concentration may be varied to achieve the desired stringency. Denaturants, such as formamide at a concentration of about 35-50% v/v, may also be used under particular circumstances, such as RNA:DNA
2s hybridizations. Appropriate hybridization conditions are routinely determinable by one of ordinary skill in the art.
"Immunologically active" or "immunogenic" describes the potential for a natural, recombinant, or synthetic peptide, epitope, polypeptide, or protein to induce antibody production in appropriate animals, cells, or cell lines.
3 0 "Insertion" or "addition" refers to a change in either a nucleic or amino acid sequence in which at least one nucleotide or residue, respectively, is added to the sequence.
"Labeling" refers to the covalent or noncovalent joining of a polynucleotide, polypeptide, or antibody with a reporter molecule capable of producing a detectable or measurable signal.

"Microarray" is any arrangement of nucleic acids, amino acids, antibodies, etc., on a substrate. The substrate may be a solid support such as beads, glass, paper, nitrocellulose, nylon, or an appropriate membrane.
"Linkers" are short stretches of nucleotide sequence which may be added to a vector or an s sptm to create restriction endonuclease sites to facilitate cloning.
"Polylinkers" are engineered to incorporate multiple restriction enzyme sites and to provide for the use of enzymes which leave 5' or 3' overhangs (e.g., BamHI, EcoRI, and HindlTl) and those which provide blunt ends (e.g., EcoRV, SnaBI, and Stul).
"Naturally occurring" refers to an endogenous polynucleotide or polypeptide that may be to , isolated from viruses or prokaryotic or eukaryotic cells.
"Nucleic acid sequence" refers to the specific order of nucleotides joined by phosphodiester bonds in a linear, polymeric arrangement. Depending on the number of nucleotides, the nucleic acid sequence can be considered an oligomer, oligonucleotide, or polynucleotide.
The nucleic acid can be DNA, RNA, or any nucleic acid analog, such as PNA, may be of genomic or synthetic origin, may be is either double-stranded or single-stranded, and can represent either the sense or antisense (complementary) strand.
"Oligomer" refers to a nucleic acid sequence of at least about 6 nucleotides and as many as about 60 nucleotides, preferably about 15 to 40 nucleotides, and most preferably between about 20 and 30, nucleotides, that may be used in hybridization or amplification technologies. Oligomers may be 2 o used as, e.g., primers for PCR, and are usually chemically synthesized.
"Operably linked" refers to the situation in which a first nucleic acid sequence is placed in a functional relationship with the second nucleic acid sequence. For instance, a promoter is operably linked to a coding sequence if the promoter affects the transcription or expression of the coding sequence. Generally, operably linked DNA sequences may be in close proximity or contiguous and, 2 s where necessary to join two protein coding regions, in the same reading frame.
"Peptide nucleic acid" (PNA) refers to a DNA mimic in which nucleotide bases are attached to a pseudopeptide backbone to increase stability. PNAs, also designated antigene agents, can prevent gene expression by targeting complementary messenger RNA.
The phrases "percent identity" and "% identity", as applied to polynucleotide sequences, refer 3 o to the percentage of residue matches between at least two polynucleotide sequences aligned using a standardized algorithm. Such an algorithm may insert, in a standardized and reproducible way, gaps in the sequences being compared in order to optimize alignment between two sequences, and therefore achieve a more meaningful comparison of the two sequences.

Percent identity between polynucleotide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEGALIGN
version 3.12e sequence alignment program. This program is part of the LASERGENE software package, a suite of molecular biological analysis programs (DNASTAR, Madison WI). CLUSTAL V is described in s Higgins, D.G. and Sharp, P.M. '(1989) CABIOS 5:151-153 and in Higgins, D.G.
et al. (1992) CABIOS
8:189-191. For pairwise alignments of polynucleotide sequences, the default parameters are set as follows: Ktuple=2, gap penalty=5, window=4, and "diagonals saved"=4. The "weighted" residue weight table is selected as the default. Percent identity is reported by CLUSTAL V as the "percent similarity" between aligned polynucleotide sequence pairs.
to Alternatively, a suite of commonly used and freely available sequence comparison algorithms is provided by the National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST) (Altschul, S.F. et al. (1990) J. Mol. Biol. 215:403-410), which is available from several sources, including the NCBI, Bethesda, MD, and on the Internet at http://www.ncbi.nlm.nih.govBLAST/. The BLAST software suite includes various sequence analysis 15 programs including "blastn," that is used to determine alignment between a known polynucleotide sequence and other sequences on a variety of databases. Also available is a tool called "BLAST 2 Sequences" that is used for direct pairwise comparison of two nucleotide sequences. "BLAST 2 .
Sequences" can be accessed and.used interactively at http:l/www.ncbi.nlm.nih.gov/gorf/b12/. The "BLAST 2 Sequences" tool can be used for both blastn and blastp (discussed below). BLAST
2 o programs are commonly used with gap and other parameters set to default settings. For example, to compare two nucleotide sequences, one may use blastn with the "BLAST 2 Sequences'' tool Version 2Ø9 (May-07-1999) set at default parameters. Such default parameters may be, for example:
Matrix: BLOSUM62 Reward for match: 1 2 s Penalty for mismatch: -2, Opera Gap: S afad Extensiota Gap: 2 penalties Gap x drop-off 50 Expect: 10 Word Size: 11 3 o Filter: on Percent identity may be measured over the length of an entire defined sequence, for example, as defined by a particular SEQ ID number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined sequence, for instance, a fragment of at least 20, at least 30, at least 40, at least 50, at least 70, at least 100, or at least 200 contiguous nucleotides. Such lengths are exemplary only, and it is understood that any fragment lengthsupported by the sequences shown herein, in figures or Sequence Listings, may be used to describe a length over which percentage identity may be measured.
s Nucleic acid sequences that do not show a high degree of identity may nevertheless encode similar amino acid sequences due to the degeneracy of the genetic code. It is understood that changes in nucleic acid sequence can be made using this degeneracy to produce multiple nucleic acid sequences that all encode substantially the same protein.
The phrases "percent identity" and "% identity", as applied to polypeptide sequences, refer to to the percentage of residue matches between at least two polypeptide sequences aligned using a standardized algorithm. Methods of polypeptide sequence alignment are well-known. Some alignment methods take into account conservative amino acid substitutions. Such conservative substitutions, explained in more detail above, generally preserve the hydrophobicity and acidity of the substituted residue, thus preserving the structure (and therefore function) of the folded polypeptide.
15 Percent identity between polypeptide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEGALIGN
version 3.12e sequence alignment program (described and referenced above). For pairwise alignments of ..
polypeptide sequences using CLUSTAL V, the default parameters are set as follows: Ktuple=1, gap penalty=3, window=5, and "diagonals saved"=5. The PAM250 matrix is selecfed as the default 2 o residue weight table. As with polynucleotide alignments, the percent identity is reported by CLUSTAL V as the "percent similarity" between aligned polypeptide sequence pairs.
Alternatively the NCBI BLAST software suite may be used. For example, for a pairwise comparison of two polypeptide sequences, one may use the "BLAST 2 Sequences'' tool Version 2Ø9 (May-07-1999) with blastp set at default parameters. Such default parameters may be, for example:
25 Matrix: BLOSUM62 Open Gap: 11 arad Exte~asion Gap: 1 penalty Gap x drop-off 50 Expect: l0 Word Size: 3 s o Filter: on Percent identity may be measured over the length of an entire defined polypeptide sequence, for example, as defined by a particular SEQ 117 number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined polypeptide sequence, for instance, a fragment of at least 15, at least 20, at least 30, at least 40, at least 50, at least 70 or at least 150 contiguous residues. Such lengths are exemplary only, and it is understood that any fragment length supported by the sequences shown herein, in figures or Sequence Listings, may be used to describe a length over which percentage identity may be measured.
"Post-translational modification" of an SPTM may involve lipidation, glycosylation, phosphorylation, acetylation, racemization, proteolytic cleavage, and other modifications known in the art. These processes may occur synthetically or biochemically. Biochemical modifications will vary by cell type depending on the enzymatic milieu and the SPTM.
"Probe" refers to sptm or fragments thereof, which are used to detect identical, allelic or to related nucleic acid sequences. Probes are isolated oligonucleotides or polynucleotides attached to a detectable label or reporter molecule. Typical labels include radioactive isotopes, ligands, chemiluminescent agents, and enzymes. "Primers" are short nucleic acids, usually DNA
oligonucleotides, which may be annealed to a target polynucleotide by complementary base-pairing.
The primer may then be extended along the target DNA strand by a DNA
polymerise enzyme.
15 Primer pairs can be used for amplification (and identification) of a nucleic acid sequence, e.g., by the polymerise chain reaction (PCR).
Probes and primers as used in the present invention typically comprise at least 15 contiguous nucleotides of a known sequence. In order to enhance specificity, longer probes and primers may also be employed, such as probes and primers that comprise ~at least 20, 30, 40, 50, 60, 70, 80, 90, 100, or at z o least 150 consecutive nucleotides of the disclosed nucleic acid sequences.
Probes and primers may be considerably longer than these examples, and it is understood that any length supposed by the specification, including the figures and Sequence Listing, may be.used.
Methods for preparing and using probes and primers are described in the references, for example Sambrook et al., 1989, Molecular Clanin~: A Laboratory Manual, 2°d ed., vol. 1-3, Cold a5 Spring Harbor Press, Plainview NY; Ausubel et a1.,1987, Current Protocols in Molecular Biolo~y, Greene Publ. Assoc. & Wiley-Intersciences, New York NY; Innis et al., 1990, PCR Protocols, A
Guide to Methods and Applications, Academic Press, San Diego CA. PCR primer pairs can be derived from a known sequence, for example, by using computer programs intended for that purpose such as Primer (Version 0.5, 1991, Whitehead Institute for Biomedical Research, Cambridge MA).
s o Oligonucleotides for use as primers are selected using software known in the art for such purpose. For example, OLIGO 4.06 software is useful for the selection of PCR
primer pairs of up to 100 nucleotides each, and for the analysis of oligonucleotides and larger polynucleotides of up to 5,000 nucleotides from an input polynucleotide sequence of up to 32 kilobases.
Similar primer selection programs have incorporated additional features for expanded capabilities. For example, the PrimOU
primer selection program (available to the public from the Genome Center at University of Texas South West Medical Center, Dallas TX) is capable of choosing specific primers from megabase sequences and is thus useful for designing primers on a genome-wide scope. The Primer3 primer s selection program (available to the public from the Whitehead Institute/MIT
Center for Genome Research, Cambridge MA) allows the user to input a "mispriming library," in which sequences to avoid as primer binding sites are user-specified. Primer3 is useful, in particular, for the selection of oligonucleotides for microarrays. (The source code for the latter two primer selection programs may also be obtained from their respective sources and modified to meet the user's specific needs.) The to PrimeGen program (available to the public from the UK Human Genome Mapping Project Resource Centre, Cambridge UK) designs primers based on multiple sequence alignments, thereby allowing selection of primers that hybridize to either the most conserved or least conserved regions of aligned nucleic acid sequences. Hence, this program is useful for identification of both unique and conserved oligonucleotides and polynucleotide fragments. The oligonucleotides and polynucleotide fragments 15 , identified by any of the above selection methods are useful in hybridization technologies, for example, as PCR or sequencing primers, microarray elements, or specific probes to identify fully or partially complementary polynucleotides in a sample of nucleic acids. Methods of oligonucleotide selection are not limited to those described above.
"Purified" refers to molecules, either polynucleotides or polypeptides that are isolated or 2o separated from their natural environment and are at least 60% free, preferably at least 75% free, and , most preferably at least 90% free from other compounds with which they are naturally associated.
A "recombinant nucleic acid" is a sequence that is not naturally occurring or has a sequence that is made by an artificial combination of two or more otherwise separated segments of sequence.
This artificial combination is often accomplished by chemical synthesis or, more commonly, by the 25 artificial manipulation of isolated segments of nucleic acids, e.g., by genetic engineering techniques such as those described in Sambrook, su ra. The term recombinant includes nucleic acids that have been altered solely by addition, substitution, or deletion of a portion of the nucleic acid. Frequently, a recombinant nucleic acid may include a nucleic acid sequence operably linked to a promoter sequence.
Such a recombinant~nucleic acid may be part of a vector that is used, for example, to transform a cell.
3 o Alternatively, such recombinant nucleic acids may be part of a viral vector, e.g., based on a vaccinia virus, that could be use to vaccinatea mammal wherein the recombinant nucleic acid is expressed, inducing a protective immunological, response in the mammal.

"Regulatory element" refers to a nucleic acid sequence from nontranslated regions of a gene, and includes enhancers, promoters, introns, and 3' untranslated regions, which interact with host proteins to carry out or regulate transcription or translation.
"Reporter" molecules are chemical or biochemical moieties used for labeling a nucleic acid, an amino acid, or an antibody. They include radionuclides; enzymes; fluorescent, chemiluminescent, or chromogenic agents; substrates; cofactors; inhibitors; magnetic particles; and other moieties known in the art.
An "RNA equivalent," in reference to a DNA sequence, is composed of the same linear sequence of nucleotides as the reference DNA sequence with the exception that all occurrences of to the nitrogenous base thymine are replaced with uracil, and the sugar backbone is composed of ribose instead of deoxyribose.
"Sample" is used in its broadest sense. Samples may contain nucleic or amino acids, antibodies, or other materials, and may be derived from any source (e.g., bodily fluids including, but not limited to, saliva, blood, and urine; chromosome(s), organelles, or membranes isolated from a cell;
is genomic DNA, RNA, or cDNA in solution or bound to a substrate; and cleared cells or tissues or blots or imprints from such cells or tissues).
"Specific binding" or "specifically binding" refers to the interaction between a protein or peptide and its agonist, antibody, antagonist, or other binding partner. The interaction is dependent upon the presence of a particular structure of the protein, e.g., the antigenic determinant or epitope, 2 o recognized by the binding molecule. For example, if an antibody is specific for epitope "A," the presence of a polypeptide containing epitope A, or the presence of free unlabeled A, in a reaction containing free labeled A and the antibody will reduce the amount of labeled A
that binds to the antibody.
"Substitution" refers to the replacement of at least one nucleotide or amino acid by a different 2 s nucleotide or amino acid.
"Substrate" refers to any suitable rigid or semi-rigid support including, e.g., membranes, filters, chips, slides, wafers, fibers, magnetic or nonmagnetic beads, gels, tubing, plates, polymers, microparticles or capillaries. The substrate can have a variety of surface forms, such as wells, trenches, pins, channels and pores, to which polynucleotides or polypeptides are bound.
3 o A "transcript image" refers to the collective pattern of gene expression by a particular tissue or cell type under given conditions at a given time.
"Transformation" refers to a process by which exogenous DNA enters a recipient cell.
Transformation may occur under natural or artificial conditions using various methods well known in the art. Transformation may rely on any known method for the insertion of foreign nucleic acid sequences into a prokaryotic or eukaryotic host cell. The method is selected based on the host cell being transformed.
"Transformants" include stably transformed cells in which the inserted DNA is capable of s replication either as an autonomously replicating plasmid or as part of the host chromosome, as well as cells which transiently express inserted DNA or RNA.
A "transgenic organism," as used herein, is any organism, including but not limited to animals and plants, in which one or more of the cells of the organism contains heterologous nucleic acid introduced by way of human intervention, such as by transgenic techniques well known in the art. The so nucleic acid is introduced into the cell, directly or indirectly by introduction into a precursor of the cell, by way of deliberate genetic manipulation, such as by microinjection or by infection with a recombinant virus. The term genetic manipulation does.not include classical cross-breeding, or in vitro fertilization, but rather is directed to the introduction of a recombinant DNA
molecule. The transgenic organisms contemplated in accordance with the present invention include bacteria, cyanobacteria, is fungi, and plants and animals. The isolated DNA of the present invention can be introduced into the host by methods known in the art, for example infection, transfection, transformation or transconjugation. Techniques for transferring the DNA of the.present invention into such organisms w are widely known and provided in references such as Sambrook et al. (1989), supra.
A "variant" of a parkicular nucleic acid sequence~is defined as a nucleic acid sequence having 2 o at least 25% sequence identity to the particular nucleic acid sequence over a certain length of one of the nucleic acid sequences using blastn with the "BLAST 2 Sequences" tool Version 2Ø9 (May-07-1999) set at default parameters. Such a pair of nucleic acids may show, for example, at least 30%, at least 50%~ at least 60%, at least 70%, at least 80%, at least 90%, at least 91 %, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% or greater 25 sequence identity over a certain defined length. The variant may result in "conservative" amino acid changes which do not affect structural and/or chemical properties. A variant may be described as, for example, an "allelic" (as defined above), "splice," "species," or "poiymorphic" variant. A splice variant may have significant identity to a reference molecule, but will generally have a greater or lesser number of polynucleotides due to alternate splicing of exons during mRNA processing. The s o corresponding polypeptide may possess additional functional domains or lack domains that are present in the reference molecule. Species variants are polynucleotide sequences that vary from one species to another. The resulting polypeptides generally will have significant amino acid identity relative to each other. A polymorphic variant is a variation in the polynucleotide sequence of a particular gene between individuals of a given species. Polymorphic variants also may encompass "single nucleotide polymorphisms" (SNPs) in which the polynucleotide sequence varies by one base.
The presence of SNPs may be indicative of, for example, a certain population, a disease state, or a propensity for a disease state.
In an alternative, variants of the polynucleotides of the present invention may be generated through recombinant methods. One possible method is a DNA shuffling technique such as MOLECULARBREEDING (Maxygen Inc., Santa Clara CA; described in U.S. Patent Number 5,837,458; Chang, C.-C. et al. (1999) Nat. Biotechnol. 17:793-797; Christians, F.C. et al. (1999) Nat.
Biotechnol. 17:259-264; and Crameri, A. et al. (1996) Nat: Biotechnol. 14:315-319) to alter or improve to the biological properties of SPTM, such as its biological or enzymatic activity or its ability to bind to other molecules or compounds. DNA shuffling is a process by which a library of gene variants is produced using PCR-mediated recombination of gene fragments. The library is then subjected to selection or screening procedures that identify those gene variants with the desired properties. These preferred variants may then be pooled and further subjected to recursive rounds of DNA shuffling and is selectionlscreening. Thus, genetic diversity is created through "artificial" breeding and rapid molecular evolution. For example, fragments of a single gene containing random point mutations may be recombined, screened, and then reshuffled until the desired properties are optimized. Alternatively, fragments of a given gene may be recombined with fragments of homologous genes in the same gene family, either from the same or different species thereby maximizing the genetic diversity of multiple 2o naturally occurring genes in a.directed and controllable manner.
A "variant" of a particular polypeptide sequence is defined as a polypeptide sequence having at least 40-% sequence identity to the particular polypeptide sequence over a certain length of one of the, polypeptide sequences using blastp with the "BLAST 2 Sequences" tool Version 2Ø9 (May-07-1999) set at default parameters. Such a pair of polypeptides may show, for example, at least 50%, at 25 least 60%, at least 70%, at least 80%, A "variant" of a particular polypeptide sequence is defined as a polypeptide sequence having at least 40% sequence identity to the particular polypeptide sequence over a certain length of one of the polypepdde sequences using blastp with the "BLAST 2 Sequences"
tool Version 2Ø9 (May-07-1999) set at default parameters. Such a pair of polypeptides may show, for example, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at Ieast 91 %, at least so 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% or greater sequence identity over a certain defined length of one of the polypeptides.
sequence identity over a certain defined length of.one of the polypeptides.

THE INVENTION
In a particular embodiment, cDNA sequences derived from human tissues and cell lines were aligned based on nucleotide sequence identity and assembled into "consensus"
or "template"
sequences which are designated by the template identification numbers (template IDs) in column 2 of s Table 2. The sequence identification numbers (SEQ ID NOa) corresponding to the template IDs are shown in column 1. Segments of the template sequences are defined by the "start' and "stop"
nucleotide positions listed in columns 3 and 4. These segments, when translated in the reading frames indicated in column 5, have similarity to signal peptide (SP) or transmembrane (TM) domain consensus sequences, as indicated in column 6.
to The invention incorporates the nucleic acid sequences of these templates as disclosed in the Sequence Listing and the use of these sequences in the diagnosis and treatment of disease states characterized by defects in cell signaling. The invention further utilizes these sequences in hybridization and amplification technologies, and in particular, in technologies which assess gene expression patterns correlated with specific cells or tissues and their responses in vivo or in vitro to is pharmaceutical agents, toxins, and other treatments. In this manner, the sequences of the present invention are used to develop a transcript image for a particular cell or tissue.
Derivation of Nucleic Acid Sequences cDNA was isolated from libraries constructed using RNA derived from normal and diseased a o human tissues and cell lines. The human tissues and cell lines used for cDNA library construction were selected from a broad range of sources to provide a diverse population of cDNAs representative of gene transcription throughout the human body. Descriptions of the human tissues and cell lines used for cDNA library construction are provided in the LIFESEQ database (Incyte Genomics, Inc.
(Incyte), Palo Alto CA). Human tissues were broadly selected from, for example, cardiovascular;
25 dermatologic, endocrine, gastrointestinal, hematopoietic/immune system, musculoskeletal, neural, reproductive, and urologic sources.
Cell lines used for cDNA library construction were derived from, for example, leukemic cells, teratocarcinomas, neuroepitheliomas, cervical carcinoma, lung fibroblasts, and endothelial cells. Such cell lines include, for example, THP-1, Jurkat, HUVEC, hNT2,, WI38, HeLa, and other cell lines 3 o commonly used and available from public depositories (American Type Culture Collection, Manassas VA). Prior to mRNA isolation, cell lines were untreated, treated with a pharmaceutical went such as 5'-aza-2'-deoxycytidine, treated with an activating agent such as lipopolysaccharide in the case of leukocytic cell lines, or, in the case of endothelial cell lines, subjected to shear stress.

Sequencing of the cDNAs Methods for DNA sequencing are well known in the art. Conventional enzymatic methods employ the Klenow fragment of DNA polymerase I, SEQUENASE DNA polymerase (U.S.
s Biochemical Corporation, Cleveland OH), Taq polymerase (Applied Biosystems, Foster City CA), thermostable T7 polymerase (Amersham Pharmacia Biotech, Inc. (Amersham Pharmacia Biotech), Piscataway NJ), or combinations of polymerases and proofreading exonucleases such as those found in the ELONGASE amplification system (Life Technologies Inc. (Life Technologies), Gaithersburg MD), to extend the nucleic acid sequence from an oligonucleotide primer annealed to the DNA
to template of interest. Methods have been developed for the use of both single-stranded and double-stranded templates. Chain termination reaction products may be electrophoresed on urea-polyacrylamide gels and detected either by autoradiography (for radioisotope-labeled nucleotides) or by fluorescence (for fluorophore-labeled nucleotides). Automated methods for mechanized reaction preparation; sequencing, and analysis using fluorescence detection methods have been developed.
is Machines used to prepare cDNAs for sequencing can include the MICROLAB 2200 liquid transfer system (Hamilton Company (Hamilton), Reno N~, Pettier thermal cycler (PTC200;
MJ Research, Inc. (MJ Research), Watertown MA), and ABI CATALYST 800 thermal eycler (Applied Biosystems). Sequencing can be carried out using, for example, the ABI 373 or 377 (Applied Biosystems) or MEGABACE 1000 (Molecular Dynamics, Inc. (Molecular Dynamics), Sunnyvale 2 o CA) DNA sequencing systems, or other automated and manual sequencing systems well known in the art.
The nucleotide sequences of the Sequence Listing have been prepared by current, state-of the-art, automated methods and, as such, may contain occasional sequencing errors or unidentified nucleotides. Such unidentified nucleotides are designated by an N. These infrequent unidentified a s bases do not represent a hindrance to practicing the invention for those skilled in the art. Several methods employing standard recombinant techniques maybe used to correct errors and complete the missing sequence information. (See, e.g., those described in Ausubel, F.M. et al. (1997) Short Protocols in Molecular Biolo~y, John Wiley & Sons, New York NY; and Sambrook, J. et al. (1989) Molecular Cloning, A Laboratory Manual, Cold Spring 'Harbor Press, Plainview NY.) Assembly of cDNA Seguences Human polynucleotide sequences may be assembled using programs or algorithms well known in the art. Sequences to be assembled are related, wholly or in part, and may be derived from a single or many different transcripts. Assembly of the sequences can be performed using such programs as PHRAP (Phils Revised Assembly Program) and the GELVIEW fragment assembly system (GCG), or other methods known in the art.
Alternatively, cDNA sequences are used as "component" sequences that are assembled into s "template" or "consensus" sequences as follows. Sequence chromatograms are processed, verified, and quality scores are obtained using PHRED. Raw sequences are edited using an editing pathway known as Block 1 (See, e.g., the LIFESEQ Assembled User Guide, Incyte Genomics, Palo Alto, CA).
A series of BLAST comparisons is performed and low-information segments and repetitive elements (e.g., dinucleotide repeats, Alu repeats, etc.) are replaced by "n's", or masked, to prevent spurious to matches. Mitochondria) and ribosomal RNA sequences are also removed. The processed sequences are then loaded into a relational database management system (RDMS) which assigns edited sequences to existing templates, if available. When additional sequences are added into the RDMS, a process is initiated which modifies existing templates or creates new templates from works in progress (i.e., nonfmal assembled sequences) containing queued sequences or the sequences themselves.
is After the new sequences have been assigned to templates, the templates can be merged into bins. If ,multiple templates exist in,one bin, the bin can be split and the templates reannotated.
Once gene bins have been generated based upon sequence alignments, bins are "clone joined"
based upon clone information. Clone joining occurs when the 5' sequence of one clone is present in one bin and the 3' sequence from the same clone is present in a different bin, indicating that the two 2 o bins should be merged into a single bin. Only bins which share at least two different clones are merged.
A resultant template sequence may contain either a partial or a full length open reading frame, or all or part of a genetic regulatory element. This variation is due in part to the fact that the full length cDNAs of many genes are several hundred, and sometimes several thousand, bases in length.
25 With current technology, cDNAs comprising the coding regions of large genes cannot be cloned because of vector limitations, incomplete reverse transcription of the mRNA, or incomplete "second strand" synthesis. Template sequences may be extended to include additional contiguous sequences derived from the parent RNA transcript using a variety of methods known to those of skill in the art.
Extension may thus be used to achieve the full length coding sequence of a gene.
Analysis of the cDNA Sequences The cDNA sequences are analyzed using a variety of programs and algorithms which are well known in the art. (See, e.g., Ausubel, 1997, supra, Chapter 7.7; Meyers, R.A. (Ed.) (1995) Molecular Biology and Biotechnology, Wiley VCH, New York NY> pp. 856-853; and Table 6.) These analyses comprise both reading frame determinations, e.g., based on triplet codon periodicity for particular organisms (Fickett, J.W. (1982) Nucleic Acids Res. 10:5303-5318);
analyses of potential start and stop codons; and homology searches.
Computer programs known to those of skill in the art for performing computer-assisted searches for amino acid and nucleic acid sequence similarity, include, for example, Basic Local Alignment Search Tool (BLAST; Altschul, S.F. (1993) J. Mol. Evol. 36:290-300;
Altschul, S.F. et al.
(1990) J. Mol. Biol. 215:403-410). BLAST is especially useful in determining exact matches and comparing two sequence fragments of arbitrary but equal lengths, whose alignment is locally maximal to and for which the alignment score meets or exceeds a threshold or cutoff score set by the user (Karlin, S. et al. (1988) Proc. Nat!. Acad. Sci. USA 85:841-845). Using an appropriate search tool (e.g., BLAST or HMM), GenBank, SwissProt, BLOCKS, PFAM and other databases may be searched for sequences containing regions of homology to a query sptm or SPTM
of the present invention.
Other approaches to the identification, assembly, storage, and display of nucleotide and polypeptide sequences are provided in "Relational Database for Storing Biomolecule Information,"
U.S.S.N. 08/947,845, filed October 9, 1997; "Project-Based Full-Length Biomolecular Sequence Database," U.S.S.N. 08/811,758, filed March 6, 1997; and "Relational Database and System for Storing Information Relating to Biomolecular Sequences," U.S.S.N. 09/034,807, filed:March 4; 1998, 2 o all of which are incorporated by reference herein in their entirety.
Protein hierarchies can be assigned to the putative encoded polypeptide based ori, e.g., motif, BLAST, or biological analysis. Methods for assigning these hierarchies are described, for example, in "Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data," U.S.S.N. 08/812,290, filed March 6, 1997, incorporated herein by reference.
Human Secretor's Sequences The sptm of the present invention may be used for a variety of diagnostic ,and therapeutic purposes. For example, an sptm may be used to diagnose a particular condition, disease, or disorder associated with cell signaling. Such conditions, diseases, and disorders include, but are not limited to, a 3 o cell proliferative disorder such as actinic keratosis, arteriosclerosis, atherosclerosis, bursitis, cirrhosis, hepatitis, mired connective tissue disease (MCTD), myelofibrosis, paroxysmal nocturnal hemoglobinuria, polycythemia vera, psoriasis, primary thrombocythemia, and cancers including adenocarcinoma, leukemia, lymphoma, melanoma, myeloma, sarcoma, teratocarcinoma, and, in particular, a cancer of the adrenal gland, bladder, bone, bone marrow, brain, breast, cervix, gall bladder, ganglia, gastrointestinal tract, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, and uterus; an immune system disorder such as such as inflammation, actinic keratosis, acquired immunodeficiency syndrome s (AIDS), Addison's disease, adult respiratory distress syndrome, allergies, ankylosing spondylitis, amyloidosis, anemia, arteriosclerosis, asthma, atherosclerosis, autoimmune hemolytic anemia, autoimmune thyroiditis, bronchitis, bursitis, cholecystitis, cirrhosis, contact dermatitis, Crohn's disease, atopic dermatitis, dermatomyositis, diabetes mellitus, emphysema, erythroblastosis fetalis, erythema nodosum, atrophic gastritis, glomerulonephritis, Goodpasture's syndrome, gout, Graves' disease, to Hashimoto's thyroiditis, paroxysmal nocturnal hemoglobinuria, hepatitis, hypereosinophilia, irritable bowel syndrome, episodic lymphopenia with lymphocytotoxins, mixed connective tissue disease (MCTD), multiple sclerosis, myasthenia gravis, myocardial or pericardial inflammation, myelofibrosis, osteoarthritis, osteoporosis, pancreatitis, polycythemia vera, polymyositis, psoriasis, Reiter's syndrome, rheumatoid arthritis, scleroderma, Sjogren's syndrome, systemic anaphylaxis, systemic lupus 15 erythematosus, systemic sclerosis, primary thrombocythemia, thrombocytopenic purpura, ulcerative colitis, uveitis, Werner syndrome, complications of cancer, hemodialysis, and extracorporeal circulation, trauma, and hematopoietic cancer including lymphoma, leukemia, and myeloma; and a neurological disorder such as epilepsy, ischemic cerebrovascular disease, stroke, cerebral neoplasms, Alzheimer's disease, Pick's disease, Huntington's disease, dementia, Parkinson's disease and other 2 o extrapyramidal disorders, amyotrophic lateral sclerosis and other motor neuron disorders, progressive neural muscular atrophy, retinitis pigmentosa, hereditary ataxias, multiple sclerosis and other demyelinating diseases; bacterial and viral meningitis, brain abscess, subdural empyema, epidural abscess, suppurative intracranial thrombophlebitis, myelitis and radiculitis, viral central nervous system disease, prion diseases including kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler-Scheinker 2 s syndrome, fatal familial insomnia, nutritional and metabolic diseases of the nervous system, neurofibromatosis, tuberous sclerosis, cerebelloretinal hemangioblastomatosis, encephalotrigeminal syndrome, mental retardation and other developmental disorder of the central nervous system, cerebral palsy, a neuroskeletal disorder, an autonomic nervous system disorder, a cranial nerve disorder, a spinal cord disease, muscular dystrophy and other neuromuscular disorder, a peripheral nervous s o system disorder, dermatomyositis and polymyositis, inherited, metabolic, endocrine, and toxic myopathy, myasthenia gravis, periodic paralysis, a mental disorder including mood, anxiety, and schizophrenic disorder, seasonal affective disorder (SAD), akathesia, amnesia, catatonia,' diabetic neuropathy, tardive dyskinesia, dystonias, paranoid psychoses, postherpetic neuralgia, and Tourette's disorder. The sptm can be used to detect the presence of, or to quantify the amount of, an sptm-related polynucleotide in a sample. This information is then compared to information obtained from appropriate reference samples, and a diagnosis is established. Alternatively, a polynucleotide complementary to a given sptm can inhibit or inactivate a therapeutically relevant gene related to the s sptm.
Analysis of sptm Expression Patterns The expression of sptm may be routinely assessed by hybridization-based methods to determine, for example, the tissue-specificity, disease-specificity, or developmental stage-specificity of to sptm expression. For example, the level of expression of sptm may be compared among different cell types or tissues, among diseased and normal cell types or tissues, among cell types or tissues at different developmental stages, or among cell types or tissues undergoing various treatments. This type of analysis is useful, for example, to assess the relative levels of sptm expression in fully or partially differentiated cells or tissues; to determine if changes in sptm expression levels are correlated is with the development or progression of specific disease states, and to assess the response of a cell or tissue to a specific therapy, for example, in pharmacological or toxicological studies. Methods for the analysis of sptm expression are based on hybridization and amplification technologies and include .
membrane-based procedures such as northern blot analysis, high-throughput procedures that utilize, for example, microarrays, and PCR-based procedures.
Hybridization and Genetic Analysis The sptm, their fragments; or complementary sequences, may be used to identify the presence of andlor to determine the degree of similarity between two (or more) nucleic acid sequences. The sptm may be hybridized to naturally occurring or recombinant nucleic acid sequences under appropriately selected temperatures and salt concentrations. Hybridization with a probe based on the nucleic acid sequence of at least one of the sptm allows for the detection of nucleic acid sequences, including genomic sequences, which are identical or related to the sptm of the Sequence Listing. , Probes may be selected from non-conserved or unique regions of at least one of the polynucleotides of SEQ ID N0:~1-184 and tested for, their ability to identify or amplify the target nucleic acid sequence 3 o using standard protocols.
Polynucleotide sequences that are capable of hybridizing, in particular, to those shown in SEQ
ID NO:1-184 and fragments thereof, can be identified using various conditions of stringency. (See, e.g., Wahl, G.M. and S.L. Berger (1987) Methods Enzymol. 152:399-407; Kimmel, A:R. (1987) Methods Enzymol. 152:507-51 l.) Hybridization conditions are discussed in "Definitions."
A probe for use in Southern or northern hybridization may be derived from a fragment of an sptm sequence, or its complement, that is up to several hundred nucleotides in length and is either single-stranded or double-stranded. Such probes may be hybridized in solution to biological materials s such as plasmids, bacterial, yeast, or human artificial chromosomes, cleared or sectioned tissues, or to artificial substrates containing sptm. Microarrays are particularly suitable for identifying the presence of and detecting the level of expression for multiple genes of interest by examining gene expression correlated with, e.g., various stages of development, treatment with a drug or compound, or disease progression. An array analogous to a dot or slot blot may be used to arrange and link polynucleotides to to the surface of a substrate using one or more of the following:
mechanical (vacuum), chemical, thermal, or UV bonding procedures. Such an array may contain any number of sptm and may be produced by hand or by using available devices, materials, and machines.
Microarrays may be prepared, used, and analyzed using methods known in the art. (See, e.g., Brennan, T.M. et al. (1995) U.S. Patent No. 5,474,796; Schena, M. et al.
(1996) Proc. Natl. Acad.
15 Sci. USA 93:10614-10619; Baldeschweiler et al. (1995) PCT application WO95/251116; Shalom D. et al. (1995) PCT application W095/35505; Heller, R.A. et al. (1997) Proc. Natl.
Acad. Sci. USA
94:2150-2155; and Heller, M.J. et al. (1997) U.S. Patent No. 5,605,662.) Probes may be labeled by either PCR or enzymatic techniques using a variety of commercially available reporter molecules. For example, commercial kits are available for radioactive 2 o and chemiluminescent labeling (Amersham Pharmacia Biotech) and for alkaline phosphatase labeling (Life Technologies). Alternatively, sptm may be cloned into commercially available vectors for the production of RNA probes. Such probes may be transcribed in the presence of at least one labeled nucleotide (e.g., 32P-ATP, Amersham Pharmacia Biotech).
Additionally the polynucleotides of SEQ ID N0:1-1 S4 or suitable fragments thereof can be a s used to isolate full length cDNA sequences utilizing hybridization and/or amplification procedures well known in the art, e.g., cDNA library screening, PCR amplification, etc. The molecular cloning of such full length cDNA sequences may employ the method of cDNA library screening with probes using the , hybridization, stringency, washing, and probing strategies described above and in Ausubel, supra, Chapters 3, 5,' and 6. These procedures may also be employed with genomic libraries to isolate s o genomic sequences of sptm in order to analyze, e.g., regulatory elements.
Genetic Mapping Gene identification and mapping are important in the investigation and treatment of almost all conditions, diseases, and disorders. Cancer, cardiovascular disease, Alzheimer's disease, arthritis, diabetes, and mental illnesses are of particular interest. Each of these conditions is more complex than the single gene defects of sickle cell anemia or cystic fibrosis, with select groups of genes being predictive of predisposition for a particular condition, disease, or disorder.
For example, s cardiovascular disease may result from malfunctioning receptor molecules that fail to clear cholesterol from the bloodstream, and diabetes may result when a particular individual's immune system is activated by an infection and attacks the insulin-producing cells of the pancreas. In.some studies, Alzheimer's disease has been linked to a gene on chromosome 21; other studies predict a different gene and location. Mapping of disease genes is a complex and reiterative process and generally to proceeds from genetic linkage analysis to physical mapping.
As a condition is noted among members of a family, a genetic linkage map traces parts of chromosomes that are inherited in the same pattern as the condition.
Statistics link the inheritance of particular conditions to particular regions of chromosomes, as defined by RFLP
or other markers.
(See, for example, Larder, E. S. and Botstein, D. (1986) Proc. Natl. Acad.
Sci. USA 83:7353-7357.) 15 Occasionally, genetic markers and their locations are known from previous studies. More often, however, the markers are simply stretches of DNA that differ among individuals. Examples of genetic linkage maps can be found in various scientific journals or at the Online Mendelian Inheritance in Man (OMIM) World Wide Web site.
In another embodiment of the invention, sptm sequences may be used to generate 2 o hybridization probes useful in chromosomal mapping of naturally occurring genomic sequences. Either coding or noncoding sequences of sptm may be used, and in some instances, noncoding sequences may be preferable over coding sequences. For example, conservation of an sptm coding sequence among members of a multi-gene family may potentially cause undesired cross hybridization during chromosomal mapping. The sequences may be mapped to a particular chromosome, to a specific 25 region of a chromosome, or to artificial chromosome constructions, e.g., human artificial chromosomes (HACs), yeast artificial chromosomes (YACs), bacterial artificial chromosomes (BACs), bacterial P1 constructions, or single chromosome cDNA libraries. (See, e.g:, Harrington, J.J. et al. (1997) Nat.
Genet. 15:345-355; Price, C.M. (1993) Blood Rev. 7:127-134; and Trask, B.J.
(1991) Trends Genet.

7:149-154.) s o Fluorescent in situ hybridization (FISH) may be correlated with other physical chromosome mapping techniques and genetic map data. (See, e.g., Meyers, supra, pp. 965-968.) Correlation between the location of sptm on a physical chromosomal map and a specific disorder, or a predisposition to a specific disorder, may help define the region of DNA
associated with that disorder.

The sptm sequences may also be used to detect polymorphisms that are genetically linked to the inheritance of a particular condition, disease, or disorder.
In situ hybridization of chromosomal preparations and genetic mapping techniques, such as linkage analysis using established chromosomal markers, may be used for extending existing genetic s maps. Often the placement of a gene on the chromosome of another mammalian species, such as mouse, may reveal associated markers even if the number or arm of the corresponding human chromosome is not known. These new marker sequences can be mapped to human chromosomes and may provide valuable information to investigators searching for disease genes using positional cloning or other gene discovery techniques. Once a disease or syndrome has been crudely correlated to by genetic linkage with a particular genomic region, e.g., ataxia-telangiectasia to 11q22-23, any sequences mapping to that area may represent associated or regulatory genes for further investigation.
(See, e.g., Gatti, R.A. et al. (1988) Nature 336:577-580.) The nucleotide sequences of the subject invention may also be used to detect differences in chromosomal architecture due to translocation, inversion, etc., among normal, carrier, or affected individuals.
15 Once a disease-associated gene is mapped to a chromosomal region, the gene must be cloned in order to identify mutations or other alterations (e.g., translocations or inversions) that may be correlated with disease. This process requires a physical map of the chromosomal region containing the disease-gene of interest along with associated markers. A physical map is necessary for determining the nucleotide sequence of and order of marker genes on a particular chromosomal 2 o region. Physical mapping techniques are well known in the art and require the generatibn of overlapping sets of cloned DNA fragments from a particular organelle, chromosome, or genome.
These clones are analyzed to reconstruct and catalog their order. Once the position of a marker is determined, the DNA from that region is obtained byconsulting the catalog and selecting clones from that region. The gene of interest is located through positional cloning techniques using hybridization or 2s similar methods.
Diagnostic Uses The sptm of the present invention may be used to design probes useful in diagnostic assays.
Such assays, well known to those skilled in the art, may be used to detect or confirm conditions, 3 o disorders, or diseases associated with abnormal levels of sptm expression.
Labeled probes developed from sptm sequences are added to a sample under hybridizing conditions of desired stringency. In some instances, sptm, or fragments or oligonucleotides derived from sptm, may be used as primers in amplification steps.prior to hybridization. The amount of hybridization complex formed is quantified and compared with standards for that cell or tissue. If sptm expression varies significantly from the standard, the assay indicates the presence of the condition, disorder, or disease. Qualitative or quantitative diagnostic methods may include northern, dot blot, or other membrane or dip-stick based technologies or multiple-sample format technologies such as PCR, enzyme-linked immunosorbent s assay (ELISA)-like, pin, or chip-based assays.
The probes described above may also be used to monitor the progress of conditions, disorders, or diseases associated with abnormal levels of sptm expression, or to evaluate the efficacy of a particular therapeutic treatment. The candidate probe may be identified from the sptm that are specific to a given human tissue and have not been observed in GenBank or other genome databases.
to Such a probe rnay be used in animal studies, preclinical tests, clinical trials, or in monitoring the treatment of an individual patient. In a typical process, standard expression is established by methods well known in the art for use as a basis of comparison, samples from patients affected by the disorder or disease are combined with the probe to evaluate any deviation from the standard profile, and a therapeutic agent is administered and effects are monitored to generate a treatment profile. Efficacy is is evaluated by determining whether the expression progresses toward or returns to the standard normal pattern. Treatment profiles may be generated over a period of several days or several months.
Statistical methods well known to those skilled in the art may be use to determine the significance of such therapeutic agents.
The polynucleotides are also useful for identifying individuals from minute biological samples;
2 o for example, by matching the RFLP pattern of a sample's~DNA to that of an individual's DNA. The polynucleotides of the present invention can also be used to determine the actual base-by-base DNA ..
sequence of selected portions-of an individual's genome. These sequences can be used to prepare PCR primers for amplifying and isolating such selected DNA, which can then be sequenced. Using this technique, an individual can be identified through a unique set of DNA
sequences. Once a unique 25 )D database is established for an individual, positive identification of that individual can be made from extremely small tissue samples.
In a particular aspect, oligonucleotide primers derived from the sptm of the invention may be used to detect single nucleotide polymorphisms (SNPs). SNPs are substitutions, insertions and deletions .:hat are a frequent cause of inherited or acquired genetic disease in humans. Methods of a o SNP detection include, but are not limited to, single.-stranded conformation polymorphism (SSCP) and fluorescent SSCP (fSSCP) methods. In SSCP, oligonucleotide primers derived from sptm are used to amplify DNA using the polymerase chain reaction (PCR). The DNA may be derived, for example, from diseased or normal tissue, biopsy samples, bodily fluids, and the like.
SNPs in the DNA cause differences in the secondary and tertiary structures of PCR products in single-stranded form, and these differences are detectable using gel electrophoresis in non-denaturing gels. In fSCCP, the oligonucleotide primers are fluorescently labeled, which allows detection of the amplimers in high-throughput equipment such as DNA sequencing machines. Additionally, sequence database analysis s methods, termed in silico SNP (isSNP), are capable of identifying polymorphisms by comparing the sequences of individual overlapping DNA fragments which assemble into a common consensus sequence. These,computer-based methods filter out sequence variations due to laboratory preparation of DNA and sequencing errors using statistical models and automated analyses of DNA sequence chromatograms. In the alternative, SNPs may be detected and characterized by mass spectrometry to using, for example, the high throughput MASSARRAY system (Sequenom, Inc., San Diego CA).
DNA-based identification techniques are critical in forensic technology. DNA
sequences taken from very small biological samples such as tissues, e.g., hair or skin, or body fluids, e.g., blood, saliva, semen, etc., can be amplified using, e.g., PCR, to identify individuals. (See, e.g., Erlich, 'H.
(1992) PCR Technolo~y, Freeman and Co., New York, NY). Similarly, polynucleotides of the present is invention can be used as polymorphic markers.
There is also a need for reagents capable of identifying the source of a particular tissue.
Appropriate reagents can comprise, for example, DNA probes or primers prepared from the sequences of the present invention that are specific for particular tissues.
Panels of such reagents can identify tissue by species and/or by organ type. In a similar fashion, these reagents can be used to 2 o screen tissue cultures for contamination.
The polynucleotides of the present invention can also be used as molecular weight markers on nucleic acid gels or Southern blots, as diagnostic probes for the presence of a specific mRNA in a particular cell type, in the creation of subtracted cDNA libraries which aid in the discovery of novel polynucleotides, in selection and synthesis of oligomers for attachment to an array or other support, 25 and as an antigen to elicit an immune response.
Disease Model Systems Using sntm The polynucleotides encoding SPTM or their mammalian homologs may be "knocked out" in an animal model system using homologous recombination in embryonic stem (ES) cells. Such s o techniques are well known in the art and are useful for the generation of animal models of human disease. (See, e.g., U.S. Patent Number 5,175,353 and U.S. Patent Number 5,767,337.) For example, mouse ES cells, such as the mouse 129/SvJ cell lined are derived from the early mouse embryo and grown in culture. The ES cells are transformed with a vector containing the gene of interest disrupted by a marker gene, e.g., the neomycin phosphotransferase gene (neo; Capecchi, M.R.~(1989) Science 244:1288-1292). The vector integrates into the corresponding region of the host genome by homologous recombination. Alternatively, homologous recombination takes place using the Cre-loxP
system to knockout a gene of interest in a tissue- or developmental stage-specific manner (March, J.D.
s (1996) Clin. Invest. 97:1999-2002; Wagner, K.U. et al. (1997) Nucleic Acids Res. 25:4323-4330).
Transformed ES cells are identified and microinjected into mouse cell blastocysts such as those from the C57BL/6 mouse strain. The blastocysts are surgically transferred to~pseudopregnant dams, and the resulting chimeric progeny are genotyped and bred to produce heterozygous or homozygous strains. Transgenic animals thus generated may be tested with potential therapeutic or toxic agents.
so The polynucleotides encoding SPTM may also be manipulated in vitro in ES
cells derived from human blastocysts. Human ES cells have the potential to differentiate into at least eight separate cell lineages including endoderm, mesoderm, and ectodermal cell types. These cell lineages differentiate into, for example, neural cells, hematopoietic lineages, and cardiomyocytes (Thomson, J.A. et al.
(1998) Science 282:1145-1147).
15 The polynucleotides encoding SPTM of the invention can also be used to create "knockin"
humanized animals (pigs) or transgenic animals (mice or rats) to model human disease. With knockin ..
technology, a region of sptm is injected into animal ES cells, and the injected sequence integrates into the animal cell genome. Transformed cells are injected into blastulae, and the blastulae are implanted as described above. Transgenic progeny or inbred lines are studied and treated with potential 2 o pharmaceutical agents to obtain information on treatment of a human disease. Alternatively, a mammal inbred to overexpress sptm, resulting, e.g., in the secretion of SPTM
in its milk, may also serve as a convenient source of that protein (Janne, J. et al. (1998) Biotechnol. Annu. Rev. 4:55-74).
Screening Assays 25 SPTM encoded by polynucleotides of the present invention may be used to screen for molecules that bind to or are bound by the encoded polypeptides. The binding of the polypeptide and the molecule may activate (agonist), increase, inhibit (antagonist), or decrease activity of the polypeptide or the bound molecule. Examples of such molecules include antibodies, oligonucleotides, proteins (e.g., receptors) or small molecules.
3 o Preferably, the molecule is closely related to the natural ligand of the polypeptide, e.g., a ligand or fragment thereof, a natural substrate, or a structural or functional mimetic. (See, Coligan et al., (1991) Current Protocols in Immunolo~y 1 (2): Chapter 5.) Similarly, the molecule can be closely related to the natural receptor to which the polypeptide binds, or to at least a fragment of the receptor, e.g., the active site. In, either case, the molecule can be rationally designed using known techniques.
Preferably, the screening for these molecules involves producing appropriate cells which express the polypeptide, either as a secreted protein or on the cell membrane. Preferred cells include cells from mammals, yeast, Drosophila, or E. coli. Cells expressing the polypeptide or cell membrane fractions s which contain the expressed polypeptide are then contacted with a test compound and binding, stimulation, or inhibition of activity of either the polypeptide or the molecule is analyzed.
An assay may simply test binding of a candidate compound to the polypeptide, wherein binding is detected by a fluorophore, radioisotope, enzyme conjugate, or other detectable label. Alternatively, the assay may assess binding in the presence of a labeled competitor.
to Additionally, the assay can be carried out using cell-free preparations, polypeptide/molecule affixed to a solid support, chemical libraries, or natural product mixtures.
The assay may also simply comprise the steps of mixing a candidate compound with a solution containing a polypeptide, measuring polypeptide/molecule activity or binding, and comparing the polypeptide/molecule activity or binding to a standard.
15 Preferably, an ELISA assay using, e.g., a monoclonal or polyclonal antibody, can measure polypeptide level in a sample. The antibody can measure polypeptide level by either binding, directly or indirectly, to the.polypeptide or by competing with the polypeptide for a substrate. -All of the above assays can be used in a diagnostic or prognostic context. The molecules discovered using these assays can be used to treat disease or to bring about a particular result in a 2o patient (e.g., blood vessel growth) by activating or inhibiting the polypeptide/molecule. Moreover, the assays can discover agents which may inhibit or enhance the production of the polypeptide from suitably manipulated cells or tissues.
Transcript Ima~in~ and Toxicological Testing 2 s Another embodiment relates to the use of sptm to develop a transcript image of a tissue or cell type. A transcript image represents the global pattern of gene expression by a particular tissue or cell type. Global gene expression patterns are analyzed by quantifying the number of expressed genes and their relative abundance under given conditions and at a given time. (See Seilhamer et al., "Comparative Gene Transcript Analysis," U.S. Patent Number 5,840,484, expressly incorporated by s o reference herein.) Thus a transcript image may be generated by hybridizing the polynucleotides of the present invention or their complements to the totality of transcripts or reverse transcripts of a particular tissue or cell type. In one embodiment, the hybridization takes place in high-throughput _ format, wherein the polynucleotides of the present invention or their complements comprise a subset of a plurality of elements on a microarray. The resultant transcript image would provide a profile of gene acti~rity pertaining to cell signaling.
Transcript images which profile sptm expression may be generated using transcripts isolated from tissues, cell lines, biopsies, or other biological samples. The transcript image may thus reflect s sptm expression iri vivo, as in the case of a tissue or biopsy sample, or in vitro, as in the case of a cell line.
Transcript images which profile sptm expression may also be used in conjunction with in vitro model systems and preclinical evaluation of pharmaceuticals, as well as toxicological testing of industrial and naturally-occurring environmental compounds. All compounds induce characteristic to gene expression patterns, frequently termed molecular fingerprints or toxicant signatures, which are indicative of mechanisms of action and toxicity (Nuwaysir, E. F. et al. (1999) Mol. Carcinog. 24:153-159; Steiner, S. and Anderson, N. L. (2000) Toxicol. Lett. 112-113:467-71, expressly incorporated by reference herein). If a test compound has a signature similar to that of a compound with known toxicity, it is likely to share those toxic properties. These fingerprints or signatures are most useful and 15 refined when they contain expression information from a large number of genes and gene families.
Ideally, a genome-wide measurement of expression provides the highest quality signature. Even genes whose expression is not altered by any tested compounds are important as well, as the levels of expression of these genes are used to normalize the rest of the expression data. The normalization procedure is useful for comparison of expression data after treatment with different compounds.
a o While the assignment of gene function to elements of a toxicant signature aids in interpretation of toxicity mechanisms, knowledge of gene function is not necessary for the statistical matching of signatures which leads to prediction of toxicity. (See, for example, Press Release 00-02 from the National Institute of Environmental Health Sciences, released February 29, 2000, available at http://www.niehs.nih.gov/oc/news/toxchip.htm.) Therefore, it is important and desirable in 2s toxicological screening using toxicant signatures to include all expressed gene sequences.
In one embodiment, the toxicity of a test compound is assessed by treating a biological sample containing nucleic acids with the test compound. Nucleic acids that are expressed in the treated biological sample are hybridized with one or more probes specific to the polynucleotides of the present invention, so that transcript levels corresponding to the polynucleotides of the present invention may be 3 o quantified. The transcript levels in the treated biological sample are compared with levels in an untreated biological sample. Differences in the transcript levels between the two samples are indicative of a toxic response caused by the test compound in the treated sample.
Another particular embodiment relates to the use of SPTM encoded by polynucleotides of the present invention to analyze the proteome of a tissue or cell type. The term proteome refers to the global pattern of protein expression in a particular tissue or cell type. Each protein component of a proteome can be subjected individually to further analysis. Proteome expression patterns or profiles, are analyzed by quantifying the number of expressed proteins and their relative abundance under s given conditions and at a given time. A profile of a cell's proteome may thus be generated by separating and analyzing the polypeptides of a particular tissue or cell type.
In one embodiment, the separation is achieved using two-dimensional gel electrophoresis, in which proteins from a sample are separated by isoelectric focusing in the first dimension, and then according to molecular weight by sodium dodecyl sulfate slab gel electrophoresis in the second dimension (Steiner and Anderson, to , supra). The proteins are visualized in the gel as discrete and uniquely positioned spots, typically by staining the gel with an agent such as Coomassie Blue or silver or fluorescent stains. The optical density of each protein spot is generally proportional to the level of the protein in the sample. The optical densities of equivalently positioned protein spots from different samples, for example, from biological samples either treated or untreated with a test compound or therapeutic agent, are is compared to identify' any changes in protein spot density related to the treatment. The proteins in the spots are partially sequenced using, for example, standard methods employing chemical or enzymatic:
cleavage followed by mass spectrometry. The identity of the protein in a spot may be determined by .
comparing its partial sequence, preferably of at least 5 contiguous amino acid residues, to the polypeptide sequences of the present invention. In some cases, further sequence data may be 20 obtained for definitive protein identification.
A proteoriiic profile may also be generated using antibodies specific for SPTM
to quantify the levels of SPTM expression. In one embodiment, the antibodies are used as elements on a microarray, and protein expression levels are quantified by exposing the microarray to the sample and detecting the levels of protein bound to each array element (Lueking, A. et al. (1999) Anal. Biochem. 270:103-x5 11; Mendoze, L. G. et al. (1999) Biotechniques 27:778-88). Detection may be performed by a variety of methods known in the art, for example, by reacting the proteins in the sample with a thiol- or amino-reactive fluorescent compound and detecting the amount of fluorescence bound at each array element.
Toxicant signatures at the proteome level are also useful for toxicological screening, and 3 o should be analyzed in parallel with toxicant signatures at the transcript level. There is a poor correlation between transcript and protein abundances for some proteins in some tissues (Anderson, N. L. and Seilhamer, J. (1997) Electrophoresis 18:533-537), so proteome toxicant signatures may be useful in the analysis of compounds which do not significantly affect the transcript image, but which alter the proteomic profile. In addition, the analysis of transcripts in body fluids is difficult, due to rapid degradation of mRNA, so proteomic profiling may be more reliable and informative in such cases.
In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins that are expressed in the treated s biological sample are separated so that the amount of each protein can be quantified. The amount of each protein is compared to the amount of the corresponding protein in an untreated biological sample.
A difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample. Individual proteins are identified by sequencing the amino acid residues of the individual proteins and comparing these partial sequences to the SPTM encoded by to polynucleotides of the present invention.
In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins from the biological sample are incubated with antibodies specific to the SPTM encoded by polynucleotides of the present invention. The amount of protein recognized by the antibodies is quantified. The amount of protein in the treated 15 biological sample is compared with the amount in an untreated biological sample. A difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample.
Transcript images may be used to profile sptm expression in distinct tissue types. This process can be used to determine cell signaling activity in a particular tissue type relative to this a o activity in a different tissue type. Transcript images may be used to generate a profile of sptm expression characteristic of diseased issue. Transcript images of tissues before and. after treatment may be used for diagnostic purposes, to monitor the progression of disease, and to monitor the efficacy of drug treatments for diseases which affect cell signaling activity.
Transcript images of cell lines can be used to assess cell signaling activity and/or to identify a s cell lines that lack or misregulate this activity. Such cell lines may then be treated with pharmaceutical agents, and a transcript image following treatment may indicate the efficacy of these agents in restoring desired levels of this ,activity. A similar approach may be used to assess the toxicity of pharmaceutical agents as reflected by undesirable changes in cell signaling activity. Candidate pharmaceutical agents may be evaluated by comparing their associated transcript images with those of 3 o pharmaceutical agents of known effectiveness.
Antisense Molecules The polynucleotides of the present invention are useful in antisense.technology. Antisense technology or therapy relies on the modulation of expression of a target protein through the specific binding of an antisense sequence to a target sequence encoding the target protein or directing its expression. (See, e.g., Agrawal, S., ed. (1996) Antisense Therapeutics, Humana Press Inc., Totawa NJ; Alama, A. et al. (1997) Pharmacol. Res. 36(3):171-178; Crooke, S.T. (1997) Adv. Pharmacol.
s 40:1-49; Sharma, H.W. and R. Narayanan (1995) Bioessays 17(12):1055-1063;
and Lavrosky, Y. et al. (1997) Biochem. Mol. Med. 62(1):11-22.) An antisense sequence is a polynucleotide sequence capable of specifically hybridizing to at least a portion of the target sequence. Antisense sequences bind to cellular mRNA and/or genomic DNA, affecting translation and/or transcription. Antisense sequences can be DNA, RNA, or nucleic acid mimics and analogs. (See, e.g., Rossi, J.J. et al. (1991) to Antisense Res. Dev. 1 (3):285-288; Lee, R. et al. (1998) Biochemistry 37(3):900-1010; Pardridge, W.M, et al. (1995) Proc. Natl. Acad. Sci. USA 92(12):5592-5596; and Nielsen, P. E. and Haaima, G.
(1997) Chem. Soc. Rev. 96:73-78.) Typically, the binding which results in modulation of expression occurs through hybridization or binding of complementary base pairs. Antisense sequences can also bind~to DNA duplexes through specific interactions in the major groove of the double helix.
15 The polynucleotides of the present invention and fragments thereof can be used as antisense sequences to modify the expression of the polypeptide encoded by sptm. The antisense sequences can be produced ex vivo, such as by using any of the ABI nucleic acid synthesizer series (Applied Biosystems) or other automated systems known in the art. Antisense sequences can also be produced .
biologically, such as by transforming an appropriate host cell with an expression vector containing the 2 o sequence of interest. (See, e.g., Agrawal, supra.) In therapeutic use, any gene delivery system suitable for introduction of the antisense sequences into appropriate target cells can be used. Antisense sequences can be delivered intracellularly in the form of an expression plasmid which, upon transcription, produces a sequence complementary to at least a portion of the cellular sequence encoding the target protein. (See, e.g., 25 Slater, J.E., et al. (1998) J. Allergy Clin. Immunol. 102(3):469-475; and Scanlon, I~.J., et al. (1995) 9(13):1288-1296.) Antisense sequences can also be introduced intracellularly through the use of viral vectors, such as retrovirus and adeno-associated virus vectors. (See, e.g., Miller, A.D. (1990)Blood 76:271; Ausubel, F.M. et al. (1995) Current Protocols in Molecular Biolo~y, John Wiley & Sons, New York NY; Uckert~ W. and W. Walther (1994) Pharmacol. Ther. 63(3):323-347.) Other gene delivery 3 o mechanisms include liposome-derived systems, artificial viral envelopes, and other systems known in the art. (See, e.g., Rossi, J.J. (1995) Br..Med. Bull. 51(1):217-225; Boado, R.J. et al. (1998) J. Pharm.
Sci. 87(11):1308-1315; and Morris, M.C. et al. (1997) Nucleic Acids Res.
25(14):2730-2736.) Expression In order to express a biologically active SPTM, the nucleotide sequences encoding SPTM or fragments thereof may be inserted into an appropriate expression vector, i.e., a vector which contains the necessary elements for transcriptional and translational control of the inserted coding sequence in s a suitable host. Methods which are well known to those skilled in the art may be used to construct expression vectors containing sequences encoding SPTM and appropriate transcriptional and translational control elements. These methods include in vitro recombinant DNA
techniques, synthetic techniques, and in vivo genetic recombination. (See, e.g., Sambrook, supra, Chapters 4, 8, 16, and 17;
and Ausubel, supra, Chapters 9, 10, 13, and 16.) to A variety of expression vector/host systems may be utilized to contain and express sequences encoding SPTM. These include, but are not limited to, microorganisms such as bacteria transformed with recombinant bacteriophage, plasmid, or cosmid DNA expression vectors;
yeast transformed with yeast expression vectors; insect cell systems infected with viral expression vectors (e.g., baculovirus);
plant cell systems transformed with viral expression vectors (e.g., cauliflower mosaic virus, CaMV, or 15 tobacco mosaic virus, TMV) or with bacterial expression vectors (e.g., Ti or pBR322 plasmids); or animal (mammalian) cell systems. (See, e.g., Sambrook, supra; Ausubel, 1995, supra, Van Heeke, G.
and S.M. Schuster (1989) J. Biol. Chem. 264:5503-5509; Bitter, G.A. et al.
(1987) Methods Enzymol.
153:516-544; Scorer, C.A. et al. (1994) Bio/Technology 12:181-184; Engelhard, E.K. et al. (1994) Proc. Natl. Acad. Sci. USA 91:3224-3227; Sandig, V. et al. (1996) Hum. Gene Ther. 7:1937-1945;
2o Takamatsu, N. (1987) EMBO J. 6:307-311; Coruzzi, G. et al. (1984) EMBO J.
3:1671-1680; Brogue, R. et al. (1984) Science 224:838-843; Winter, J. et al. (1991) Results Probl.
Cell Differ. 17:85-105;
The McGraw HillYearbook of Science and Technolo~y (1992) McGraw Hill, New York NY, pp.
191-196; Logan, J. and T. Shenk (1984) Proc. Natl. Acad. Sci. USA 81:3655-3659; and Harrington, J.J. et al. (1997) Nat. Genet. 15:345-355.) Expression vectors derived from retroviruses, as adenoviruses, or herpes or vaccinia viruses, or from various bacterial plasmids, may be used for delivery of nucleotide sequences to the targeted organ, tissue, or cell population. (See,.e.g., Di Nicola, M. et al. (1998) Cancer Gen. Ther. 5(6):350-356; Yu, M. et al., (1993) Proc.
Natl. Acad. Sci. USA
90(13):6340-6344; Butler, R.M. et al. (1985) Nature 317(6040):813-815;
McGregor, D.P, et al. (1994) Mol. Immunol: 31(3):219-226; and Verma, LM. and N. Somia (1997) Nature 389:239-242.) The s o invention is not limited by the host cell employed.
For long term production of recombinant proteins in mammalian systems, stable expression of SPTM in cell lines is preferred. For example, sequences encoding SPTM can be transformed into cell lines using expression vectors which may contain viral origins of replication and/or endogenous expression elements and a selectable marker gene on the same or on a separate vector. Any number of selection systems may be used to recover transformed cell lines. (See, e.g., Wigler, M. et al.
(1977) Cell 11:223-232; Lowy, I. et al. (1980) Cell 22:817-823.; Wigler, M. et al. (1980) Proc. Natl.
Acad. Sci. USA 77:3567-3570; Colbere-Garapin, F. et al. (1981) J. Mol. Biol.
150:1-14; Hartman, S.C.
s and R.C.Mulligan (1988) Proc. Natl. Acad. Sci. USA 85:8047-8051; Rhodes, C.A. (1995) Methods Mol. Biol. 55:121-131.) Therapeutic Uses of sptm The polynucleotides encoding SPTM of the invention may be used for somatic or germline to gene therapy. Gene therapy may be performed to (i) correct a genetic deficiency (e.g., in the cases of severe combined immunodeficiency (SCID)-Xl disease characterized by X-linked inheritance (Cavazzana-Calvo, M. et al. (2000) Science 288:669-672), severe combined immunodeficiency syndrome associated with an inherited adenosine deaminase (ADA) deficiency (Blaese, R.M. et al.
(1995) Science 270:475-480; Bordignon, C. et al. (1995) Science 270:470-475), cystic fibrosis (Zabner, 15 J. et al. (1993) Cell 75:207-216; Crystal, R.G. et al. (1995) Hum. Gene Therapy 6:643-666; Crystal, R.G. et al. (1995) Hum. Gene Therapy 6:667-703), thalassemias, familial hypercholesterolemia, and hemophilia resulting from Factor VIII or Factor IX deficiencies (Crystal, R.G.
(1995) Science 270:404-410; Verma~ LM. and Somia, N. (1997) Nature 389:239-242)), (ii) express a conditionally lethal gene product (e.g., in the case of cancers which result from unregulated cell proliferation), or 20 (iii) express a protein which affords protection against intracellular parasites (e.g., against human retroviruses, such as human immunodeficiency virus (HIV) (Baltimore, D. (1988) Nature 335:395-396; Poeschla, E..et al. (1996) Proc. Natl. Acad. Sci. USA. 93:11395-11399), hepatitis B or C virus (HBV, HCV); fungal parasites, such as Candida alliicans and Paracoccidioides brasiliensis; and protozoan parasites such as Plasmodium falciparum and Tr<rpanosoma cruzi). In the case where a 25 genetic deficiency in sptm expression or regulation causes disease, the expression of sptm from an appropriate population of transduced cells may alleviate the clinical manifestations caused by the genetic deficiency.
In a further embodiment of the invention, diseases or disorders caused by deficiencies in sptm are treated by constructing mammalian expression vectors comprising sptm and introducing these s o vectors by mechanical means into sptm-deficient cells. Mechanical transfer technologies for use with cells in vivo or ex vitro include (i) direct DNA microinjection into individual cells, (ii) ballistic gold particle delivery, (iii) liposome-mediated transfection, (iv) receptor-mediated gene transfer, and (v) the use of DNA transposons (Morgan, R.A. and Anderson, W.F. (1993) Annu. Rev.
Biochem. 62:191-217; Ivics, Z. (1997) Cell 91:501-510; Boulay, J-L. and Recipon, H. (1998) Curr. Opin. Biotechnol.
9:445-450).
Expression vectors that may be effective for the expression of sptm include, but are not limited to, the PCDNA 3.1, EPITAG, PRCCMV2, PREP, PVAX vectors (Invitrogen, Carlsbad CA), s PCMV-SCRIPT, PCMV-TAG, PEGSH/PERV (Stratagene, La Jolla CA), and PTET-OFF, PTET-ON, PTRE2, PTRE2-LUC, PTK-HYG (Clontech, Palo Alto CA). The sptm of the invention may be expressed using (i) a constitutively active promoter, (e.g., from cytomegalovirus (CMV), Rous sarcoma virus (RSV), SV40 virus, thymidine kinase (TK), or (3-actin genes), (ii) an inducible promoter (e.g., the tetracycline-regulated promoter (Gossen, M. and Bujard, H. (1992) Proc. Natl. Acad. Sci.
to U.S.A. 89:5547-5551; Gossen, M. et al., (1995) Science 268:1766-1769;
Rossi, F.M.V. and Blau, H.M. (1998) Curr. Opin. Biotechnol. 9:451-456), commercially available in the T-REX plasmid (Invitrogen); the ecdysone-inducible promoter (available in the plasmids PVGRXR and PIND;
Invitrogen); the FK506/rapamycin inducible promoter; or the RU486/mifepristone inducible promoter (Rossi, F.M.V. and Blau, H.M. suQra), or (iii) a tissue-specific promoter or the native promoter of the is endogenous gene encoding SPTM from a normal individual.
Commercially available liposome transformation kits (e.g., the PERFECT LIPID
TRANSFECTION KIT, available from Invitrogen) allow one with ordinary skill in the art to deliver polynucleotides to target cells in culture and require minimal effort to optimize experimental .r parameters. In the alternative, transformation is performed using the calcium phosphate method 20 (Graham, F.L. and Eb, A.J. (1973) Virology 52:456-467), or by electroporation (Neumann, E. et al.
(1982) EMBO J. 1:841-845). The introduction of DNA to primary cells requires modification of these standardized mammalian transfection protocols.
In another embodiment of the invention, diseases or disorders caused by genetic defects with respect to sptm expression are treated by constructing a retrovirus vector consisting of (i) sptm under 25 the control of an independent promoter or the retrovirus long terminal repeat (LTR) promoter, (ii) appropriate RNA packaging signals, and (iii) a Rev-responsive element (RRE) along with additional retrovirus cis-acting RNA sequences and coding sequences required for efficient vector propagation.
Retrovirus vectors (e.g., PFB and PFBNEO) are commercially available (Stratagene) and are based on published data (Riviere, I. et al. (1995) Proc. Natl. Acad. Sci. U.S.A.
92:6733-6737), incorporated 3 o by reference herein. The vector is propagated in an appropriate vector producing cell fine (VPCL) that expresses an envelope gene with a tropism for receptors on the target cells or a promiscuous envelope protein such as VSVg (Armentano, D. et al. (1987) J. Virol. 61:1647-1650; Bender, M.A. et al. (1987) J. Virol. 61:1639-1646; Adam, M.A. and Miller, A.D. (1988) J.
Virol. 62:3802-3806; Dull, T.

et al. (1998) J. Virol. 72:8463-8471; Zufferey, R. et al. (1998) J. Virol.
72:9873-9880). U.S. Patent Number 5,910,434 to Rigg ("Method for obtaining retrovirus packaging cell lines producing high transducing efficiency retroviral supernatant") discloses a method for obtaining retrovirus packaging cell lines and is hereby incorporated by reference. Propagation of retrovirus vectors, transduction of a s population of cells (e.g., CD4+ T-cells), and the return of transduced cells to a patient are procedures well known to persons skilled in the art of gene therapy and have been well documented (Ranga, U. et al. (1997) J. Virol. 71:7020-7029; Bauer, G. et al. (1997) Blood 89:2259-2267;
Bonyhadi, M.L. (1997) J. Virol. 71:4707-4716; Ranga, U. et al. (1998) Proc. Natl. Acad. Sci. U.S.A.
95:1201-1206; Su, L.
(1997) Blood 89:2283-2290).
to In the alternative, an adenovirus-based gene therapy delivery system is used to deliver sptm to cells which have one or more genetic abnormalities with respect to the expression of sptm. The construction and packaging of adenovirus-based vectors are well known to those with ordinary skill in the art. Replication defective adenovirus vectors have proven to be versatile for importing genes encoding immunoregulatory proteins into intact islets in the pancreas (Csete, M.E. .et al. (1995) 15 Transplantation 27:263-268). Potentially useful adenoviral vectors are described in U.S. Patent Number 5,707,618 to Armentano ("Adenovirus vectors for gene therapy"), hereby incorporated by reference. For adenoviral vectors, see also Antinozzi, P.A: et al. (1999) Annu. Rev. Nutr. 19:511-544:e and Verma, LM. and Somia, N. (1997) Nature 18:389:239-242, both incorporated by reference herein.' In another alternative a herpes-based, gene therapy delivery system is used to deliver sptm to 20 target cells which have one or more genetic abnormalities with respect to the expression of sptm. The:
use of herpes simplex virus (HSV)-based vectors may be especially valuable for introducing sptm to cells of the central nervous system, for which HSV has a tropism. The construction and packaging of herpes-based vectors are well known to those with ordinary skill in the art. A
replication-competent herpes simplex virus (HSV) type 1-based vector has been used to deliver a reporter gene to the eyes 2s of primates (Liu, X. et al. (1999) Exp. Eye Res.169:385-395). The construction of a HSV-1 virus vector has also been disclosed in detail in U.S. Patent Number 5,804,413 to DeLuca ("Herpes simplex virus strains for gene transfer"), which is hereby incorporated by reference.
U.S. Patent Number 5,804,413 teaches the use of recombinant HSV d92 which consists of a genome containing at least one exogenous gene to be transferred to a cell under the control of the appropriate promoter for s o purposes including human gene therapy. Also taught by this patent are the construction and use of recombinant HSV strains deleted for ICP4, ICP27 and ICP22. For HSV vectors, see also Goins, W.
F. et al. 1999 J. Virol. 73:519-532 and Xu, H. et al., (1994) Dev. Biol.
163:152-161, hereby incorporated by reference. The manipulation of cloned herpesvirus sequences, the generation of recombinant virus following the transfection of multiple plasmids containing different segments of the large herpesvirus genomes, the growth and propagation of herpesvirus, and the infection of cells with herpesvirus are techniques well known to those of ordinary skill in the art.
In another alternative, an alphavirus (positive, single-stranded RNA virus) vector is used to s deliver sptm to target cells. The biology of the prototypic alphavirus, Semliki Forest Virus (SFV), has been studied extensively and gene transfer vectors have been based on the SFV
genome (Garoff, H.
and Li, K-J. (1998) Curr. Opin. Biotech. 9:464-469). During alphavirus RNA
replication, a subgenomic RNA is generated that normally encodes the viral capsid proteins.
This subgenomic RNA
replicates to higher levels than the full-length genomic RNA, resulting in the overproduction of capsid to proteins relative to the viral proteins with enzymatic activity (e.g., protease and polymerase).
Similarly, inserting sptm into the alphavirus genome in place of the capsid-coding region results in the production of a large number of sptm RNAs and the synthesis of high levels of SPTM in vector transduced cells. While alphavirus infection is typically associated with cell lysis within a few days, the ability to establish a persistent infection in hamster normal kidney cells (BHK-21 ) with a variant of is Sindbis virus (SIN) indicates that the lytic replication of alphaviruses can be altered to suit the needs of the gene therapy application (Dryga, S.A. et al. (1997) Virology 228:74-83).
The wide host range of alphaviruses will allow the introduction of sptm into a variety of cell types.
The specific transduction .
of a subset of cells in a population may require the sorting of cells prior to transduction. The methods of manipulating infectious cDNA clones of alphaviruses~ performing alphavirus cDNA and RNA
2 o transfections, and performing alphavirus infections, are well known to those with ordinary skill in the art.
Antibodies Anti-SPTM antibodies may be used to analyze protein expression levels. Such antibodies as include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, and Fab fragments. For descriptions of and protocols of antibody technologies, see, e.g., Pound J.D.
(1998) Immunochemical Protocols, Humana Press, Totowa, NJ.
The amino acid sequence encoded by the sptm of the Sequence Listing may be analyzed by appropriate software (e.g., LASERGENE NAVIGATOR software, DNASTAR) to determine s o regions of high immunogenicity. The optimal sequences for immunization are selected from the C-terminus, the N-terminus, and those intervening, hydrophilic regions of the polypeptide which are likely to be exposed to the external environment when the polypeptide is in its natural conformation.
Analysis used to select appropriate epitopes is also described by Ausubel (1997, supra, Chapter 11.7).

Peptides used for antibody induction do not need to have biological activity;
however, they must be antigenic. Peptides used to induce specific antibodies may-have an amino acid sequence consisting of at least five amino acids, preferably at least 10 amino acids, and most preferably at least 15 amino acids. A peptide which mimics an antigenic fragment of the natural polypeptide may be fused with s another protein such as keyhole limpet hemocyanin (KLH; Sigma, St. Louis MO) for antibody production. A peptide encompassing an antigenic region may be expressed from an sptm, synthesized as described above, or purified from human cells.
Procedures well known in the art may be used for the production of antibodies.
Various hosts including mice, goats, and rabbits, may be immunized by injection with a peptide. Depending on the to host species, various adjuvants may be used to increase immunological response.
In one procedure, peptides about 15 residues in length may be synthesized using an ABI 431A
peptide synthesizer (Applied Biosystems) using fmoc-chemistry and coupled to KI,H (Sigma) by reaction with M-maleimidobenzoyl-N-hydroxysuccinimide ester (Ausubel, 1995, supra). Rabbits are immunized with the peptide-I~LH complex in complete Freund's adjuvant. The resulting antisera are 15 tested for antipeptide activity by binding the peptide to plastic, blocking with 1 % bovine serum albumin (BSA), reacting with rabbit antisera; washing, and reacting with radioiodinated goat anti-rabbit IgG.
Antisera with antipeptide activity are tested- for anti-SPTM activity using protocols well known in the art, including ELISA, radioimmunoassay (RIA), and immunoblotting.
In another procedure, isolated and purified peptide may be used to immunize mice (about 100 ao ~g of peptide) or rabbits (about 1 mg of peptide). Subsequently, the peptide is radioiodinated and used to screen the immunized animals' B-lymphocytes for production of antipeptide antibodies. Positive cells are then used to produce hybridomas using standard techniques. About 20 mg of peptide is sufficient for labeling and screening several thousand clones. Hybridomas of interest are detected by screening with radioiodinated peptide to identify those fusions producing peptide-specific monoclonal 2s antibody. In a typical protocol, wells of a mufti-well plate (FAST, Becton-Dickinson, Palo Alto, CA) are coated with affinity-purified, specific rabbit-anti-mouse (or suitable anti-species IgG) antibodies at mg/ml. The coated wells are blocked with 1 % BSA and washed and exposed to supernatants from hybridomas. After incubation, the wells are exposed to radiolabeled peptide at 1 mg/ml.
Clones producing antibodies bind a quantity of labeled peptide that is detectable above a o background. Such clones are expanded and subjected to 2 cycles of cloning.
Cloned hybridomas are injected into pristane-treated mice to produce ascites, and monoclonal antibody is purified from the ascitic fluid by affinity chromatography on protein A (Amersham Pharmacia Biotech). Several procedures for the production of monoclonal antibodies, including in vitro production, are described in Pound su ra). Monoclonal antibodies with antipeptide activity are tested for anti-SPTM activity using protocols well known in the art, including ELISA, RIA, and immunoblotting.
Antibody fragments containing specific binding sites for an epitope may also be generated.
For example, such fragments include, but are not limited to, the F(ab~2 fragments produced by pepsin s digestion of the antibody molecule, and the Fab fragments generated by reducing the disulfide bridges of the F.(ab~2 fragments. Alternatively, construction of Fab expression libraries in filamentous bacteriophage allows rapid and easy identification of monoclonal fragments with desired specificity (Pound, supra, Chaps. 45-47). Antibodies generated against polypeptide encoded by sptm can be used to purify and characterize full-length SPTM protein and its activity, binding partners, etc.
Assays Using Antibodies Anti-SPTM antibodies may be used in assays to quantify the amount of SPTM
found in a particular human cell. Such assays include methods utilizing the antibody and a label'to detect expression level under normal or disease conditions. The peptides and antibodies of the invention may be used with or without modification or labeled by joining them, either covalently or noncovalently, with a reporter molecule.
Protocols for detecting and measuring protein expression using either polyclonal or monoclonal antibodies are well known in the art. Examples include ELISA, RIA, and fluorescent activated cell sorting (FACS). Such immunoassays typically involve the formation of complexes between the SPTM
2 o and its specific antibody and the measurement of such complexes. These and other assays are described in Pound su ra).
Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent: The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not liinitative of the remainder of the disclosure in any way whatsoever.
The disclosures of all patents, applications, and publications mentioned above and below, including U.S: Ser. No. 60/230,517, U.S. Ser. No. 60/230,599, U.S. Ser.
No. 60/230,514, U.S.
U.S. Ser. No. 60/230,988, U.S. Ser. No. 60/230,518, U.S. Ser. No. 60/230,515, U.S. Ser. No.
60/229,751, U.S. Ser. No. 60/230,016, U.S. Ser. No. 60/230,610, U.S. Ser. No.
60/229,749, U.S. Sex.
3o No. 60/229,750, U.S. Ser. No. 60/230,597, U.S. Ser. No. 60/230,505, U.S.
Ser. No. 60/231,163, U.S.
Ser. No. 60/229,747, U.S. Ser. No. 60/229,748, U.S. Ser. No. 60/230,583, U.S.
Ser. No. 60/230,519, U.S. Ser. No. 60/230,595, U.S. Ser. No. 60/230,896, U.S. Ser. No. 60/230,990, U.S. Ser. No.
60/230,865, U.S. Ser. No. 60/230,989, U.S. Ser. No. 60/230,897, U.S. Ser. No.
60/231,832, U.S. Sex.

No. 60/230,596, U.S. Ser. No. 60/230,864, and U.S. Ser. No. 60/230,951 are hereby expressly incorporated by reference.
EXAMPLES
s I. Construction of cDNA Libraries RNA was purchased from CLONTECH Laboratories, Inc. (Palo Alto CA) or isolated from various tissues. Some tissues were homogenized and lysed in guanidinium isothiocyanate, while others were homogenized and lysed in phenol or in a suitable mixture of denaturants, such as TRIZOL (Life Technologies), a monophasic solution of phenol and guanidine isothiocyanate.
The resulting lysates to were centrifuged over CsCI cushions or extracted with chloroform. RNA was precipitated with either isopropanol or sodium acetate and ethanol, or by other routine methods.
Phenol extraction and precipitation of RNA were repeated as necessary to increase RNA
purity. In most cases, RNA was treated with DNase. For most libraries, poly(A+) RNA was isolated using oligo d(T)-coupled paramagnetic particles (Promega Corporation (Promega), Madison WI), . is OLIGOTEX latex particles (QIAGEN, Inc. (QIAGEN), Valencia CA), or an OLIGOTEX mRNA
purification kit (QIAGEN). Alternatively, RNA was isolated directly from tissue lysates using other RNA isolation kits, e.g., the POLY(A)PURE mRNA purification kit (Ambion, Inc., Austin TX).
In some cases, Stratagene was provided with RNA and constructed the corresponding cDNA
libraries. 'Otherwise, cDNA was synthesized arid cDNA libraries were constructed with the 2 o UNIZAP vector system (Stratagene Cloning Systems, Inc. (Stratagene), La Jolla CA) or SUPERSCRIPT plasmid system (Life Technologies), using the recommended procedures or similar methods known in.the art. (See, e.g., Ausubel, 1997, supra, Chapters 5.1 through 6.6.) Reverse transcription was initiated using oligo d(T) or random primers. Synthetic oligonucleotide adapters were ligated to double stranded cDNA, and the cDNA was digested with the appropriate restriction 2s enzyme or enzymes. For most libraries, the cDNA was size-selected (300-1000 bp) using SEPHACRYL 51000, SEPHAROSE CL2B, or SEPHAROSE CL4B column chromatography (Amersham Pharmacia Biotech) or preparative agarose gel electrophoresis. cDNAs were ligated into compatible restriction enzyme sites of the polylinker of a suitable plasmid, e.g., PBLUESCRIPT
plasmid (Stratagene), PSPORT1 plasmid (Life Technologies), PCDNA2.1 plasmid (Invitrogen, s o Carlsbad CA), PBK-CMV plasmid (Stratagene), or pINCY (Incyte Genomics, Palo Alto CA), or derivatives thereof. Recombinant plasmids were transformed into competent E.
coli. cells including XLl-Blue, XLl-BIueMRF, or SOLR from Stratagene or DHSa, DH10B, or ElectroMAX

from Life Technologies. _ II. Isolation of cDNA Clones Plasmids were recovered from host cells by in vivo excision using the UNIZAP
vector system (Stratagene) or by cell lysis. Plasmids were purified using at least one of the following: the Magic or WIZARD Minipreps DNA purification system (Promega); the AGTC Miniprep purification kit (Edge BioSystems, Gaithersburg MD); and the QIAWELL 8, QIAWELL 8 Plus, and QIAWELL 8 Ultra plasmid purification systems or the R.E.A.L. PREP 96 plasmid purification kit (QIAGEN). Following precipitation, plasmids were resuspended in 0.1 ml of distilled water and stored, with or without lyophilization, at 4°C.
Alternatively, plasmid DNA was amplified from host cell lysates using direct link PCR in a to high-throughput format. (Rao, V.B. (1994) Anal. Biochem. 216:1-14.) Host cell lysis and thermal cycling steps were carried out in a single reaction mixture. Samples were processed and stored in 384-well plates, and the concentration of amplified plasmid DNA was quantified fluorometrically using PICOGREEN dye (Molecular Probes, Inc. (Molecular Probes), Eugene OR) and a FLUOROSKAN
II fluorescence scanner (Labsystems Oy, Helsinki, Finland).
III. Sequencing and Analysis cDNA sequencing reactions were processed using standard methods or high-throughput instrumentation such as the ABI CATALYST 800 thermal cycler (Applied Biosystems) or the PTC- ' 200 thermal cycler (MJ Research) in conjunction with the HYDRA microdispenser (Robbins 2 o Scientific Corp., Sunnyvale CA) or the MICROLAB 2200 liquid transfer system (Hamilton). cDNA
sequencing reactions were prepared using reagents provided by Amersham Pharmacia Biotech or supplied in ABI sequencing kits such as the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems). Electrophoretic separation of cDNA
sequencing reactions and detection of labeled polynucleotides were carried out using the MEGABACE

sequencing system (Molecular Dynamics); the ABI PRISM 373 or 377 sequencing system (Applied Biosystems) in conjunction with standard ABI protocols and base calling software; or other sequence analysis systems known in the art. Reading frames within the cDNA sequences were identified using standard methods (reviewed in Ausubel, 1997, supra, Chapter 7.7). Some of the cDNA sequences were selected for extension using the techniques disclosed in Example VIII.
IV. Assembly and Analysis of Sequences Component sequences from chromatograms were subject to PHRED analysis and assigned a quality score. The sequences having at least a required quality score were subject to various pre-processing editing pathways to eliminate, e.g., low quality 3' ends, vector and linker sequences, polyA
tails, Alu repeats, mitochondrial and ribosomal sequences, bacterial contamination sequences, and sequences smaller than 50 base pairs. In particular, low-information sequences and repetitive elements (e.g., dinucleotide repeats, Alu repeats, etc.) were replaced by "n's", or masked, to prevent s spurious matches.
Processed sequences were then subject to assembly procedures in which the sequences were assigned to gene bins (bins). Each sequence could only belong to one bin.
Sequences in each gene bin were assembled to produce consensus sequences (templates). Subsequent new sequences were added to existing bins using BLASTn (v.1.4 WashLl) and CROSSHATCH. Candidate pairs were to identified as all BLAST hits having a quality score greater than or equal to 150. Alignments of at least 82% local identity were accepted into the bin. The component sequences from each bin were assembled using a version of PHRAP. Bins with several overlapping component sequences were assembled using DEEP PHRAP. The orientation (sense or antisense) of each assembled template was determined based on the number and orientation of its component sequences Template 15 sequences as disclosed in the sequence listing correspond to sense strand sequences (the "forward"
reading frames), to the best determination. The complementary (antisense) strands are inherently disclosed herein. The component sequences which were used to assemble each template consensus sequence are listed in Table 3 along with their positions along the template nucleotide sequences:
Bins were compared against each other and those having local similarity of at least 82% were ao combined and reassembled. Reassembled bins having templates of insufficient overlap (less than 95%
local identity) were re-split. Assembled templates were also subject to analysis by STITCHER/EXON MAPPER algorithms which analyze the probabilities of the presence of splice variants, alternatively spliced exons, splice junctions, differential expression of alternative spliced genes across tissue types or disease states, etc. These resulting bins were subject to several rounds as of the above assembly procedures.
Once gene bins were generated based upon sequence alignments, bins were clone joined based upon clone information. If the 5' sequence of one clone was present in one bin and the 3' sequence from the same clone was present in a different bin, it was likely that the two bins actually belonged together in a single bin. The resulting combined bins underwent assembly procedures to 3 o regenerate the consensus sequences.
The final assembled.templates were subsequently annotated using the following procedure.
Template sequences were analyzed using BLASTn (v2.0, NCBn versus gbpri (GenBank version 124). "Hits" were defined as an exact match having from 95% local identity over 200 base pairs through 100% local identity over 100 base pairs, or a homolog match having an E-value, i.e. a probability score, of < 1 x 10-8. The hits were subject to frameshift FASTx versus GENPEPT
(GenBank version 124). (See Table 6). In this analysis, a homolog match was defined as having an E-value of <_ 1 x 10-8. The assembly method used above was described in "System and Methods for s Analyzing Biomolecular Sequences," U.S.S.N. 09/276,534, filed March 25, 1999, and the LIFESEQ
Gold user manual (Incyte) both incorporated by reference herein.
Following assembly, template sequences were subjected to motif, BLAST, and functional analyses, and categorized in protein hierarchies using methods described in, e.g., "Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data," U.S.S:N.
l0 08/812,290, filed March 6, 1997; "Relational Database for Storing Biomolecule Information," U.S.S.N.
08/947,845, filed October 9, 1997; "Project-Based Full-Length Biomolecular Sequence Database,"
U.S.S.N. 08/811,758, filed March 6, 1997; and "Relational Database and System for Storing Information Relating to Biomolecular Sequences," U.S.S.N. 09/034,807, filed March 4, 1998, all of which are incorporated by reference herein.
15 The template sequences were further analyzed by translating each template in all three forward reading frames and searching each translation against the Pfam database of hidden Markov model-based protein families and domains using the HMMER software package (available to the public from Washington University School of Medicine, St. Louis MO). (See also World Wide Web site http://pfam.wustl.edu/ for detailed- descriptions of Pfam protein domains and families.) 2 o Additionally, the template sequences were translated in all three forward reading frames, and each translation was searched against hidden Markov models for signal peptides using the HMMER
software~package. Construction of hidden Markov models and their usage in sequence analysis has been described. (See, for example, Eddy, S.R. (1996) Curr. Opin. Str. Biol.
6:361-365.) Only those signal peptide hits with a cutoff score of 11 bits or.greater are reported. A
cutoff score of 11 bits or 2s greater corresponds to at least about 91-94% true-positives in signal peptide prediction. Template sequences were also translated in all three forward reading frames, and each translation was searched against TMAP,, a program that uses weight matrices to delineate transmembrane segments on protein sequences. and determine orientation, with respect to the cell cytosol (Persson, B. and Argot, P. (1994) J. Mol. Biol. 237:182-192, and Persson, B. and Argos, P.
(1996) Protein Sci. 5:363-3 0 371.) Regions of templates which, when translated, contain similarity to signal peptide or transmembrane consensus sequences are reported in Table 2.
Template sequences are further analyzed using the bioinformatics tools listed in Table 6, or using sequence analysis software known in the art such as MACDNASIS PRO
software (Hitachi Software Engineering, South San Francisco CA) and LASERGENE software (DNASTAR).
Template sequences may be further quexied against public databases such as the GenBank rodent, mammalian, vertebrate, prokaryote, and eukaryote databases.
The template sequences were translated to derive the corresponding longest open reading s frame as presented by the polypeptide sequences as reported in Table 1.
Alternatively, a polypeptide of the invention may begin at any of the methionine residues within the full length translated polypeptide. Polypeptide sequences were subsequently analyzed by querying against the GenBank protein database' (GENPEPT, (GenBank version 124)). Full length polynucleotide sequences are also analyzed using MACDNASIS PRO software (Hitachi Software Engineering, South San Francisco 1 o CA) and LASERGENE software (DNASTAR). PolynucIeotide and polypeptide sequence alignments are generated using default parameters specified by the CLUSTAL algorithm as incorporated into the MEGALIGN muItisequence alignment program (DNASTAR), which also calculates the percent identity between aligned sequences.
Table 5 shows sequences with homology to the polypeptides of the invention as identified by 15 BLAST analysis against the GenBank protein (GENPEPT) database. Column 1 shows the polypeptide sequence identification number (SEQ >D NO:) for the polypeptide segments of the invention. Column 2 shows the reading frame used in the translation of the polynueleotide sequences encoding the polypeptide segments. Column 3 shows the length of the translated polypeptide segments. Columns 4 and 5 show the start and stop nucleotide positions of the polynucleotide 2 o sequences encoding the polypeptide segments. Column 6 shows the GenBank identification number (GI Number) of the nearest GenBank homolog. Column 7 shows the probability score for the match between each polypeptide and its GenBank homolog. Column 8 shows the annotation of the GenBank homolog.
2 s V. Analysis of Polynacleotide Expression Northern analysis is a laboratory technique used to detect the presence of a transcxipt of a gene and involves the hybridization of a labeled nucleotide sequence to a membrane on which RNAs from a particular cell type or tissue have been bound. (See, e.g., Sambrook, su~a, ch. 7; Ausubel, 1995, supra, ch. 4 and 16.) 3 o Analogous computer techniques applying BLAST were used to search for identical or related molecules in cDNA databases such as GenBank or LIFESEQ (Incyte Genomics)~.
This analysis is much faster than multiple membrane-based hybridizations. In addition, the sensitivity of the computer search can be modified to determine whether any particular match is categorized as exact or similar.

The basis of the search is the product score, which is defined as:
BLAST Score x Percent IdentiW
Xminimum {length(Seq. 1), length(Seq. 2)}

The product score takes into account both the degree of similarity between two sequences and the length of the sequence match. The product score is a normalized value between 0 and 100, and is calculated as follows: the BLAST score is multiplied by the percent nucleotide identity and the product is divided by (5 times the length of the shorter of the two sequences). The BLAST score is t o calculated by assigning a score of +5 for every base that matches in a high-scoring segment pair (HSP), and -4 for every mismatch. Two sequences may share more than one HSP
(separated by gaps). If there is more than one HSP, then the pair with the highest BLAST
score is used to calculate the product score. . The product score represents a balance between fractional overlap and quality in a BLAST alignment. For example, a product score of 100 is produced only for 100%
identity over the entire length of the shorter of the two sequences being compared. A product score of 70 is produced either by 100% identity and 70% overlap at one end, or by 88% identity and 100% overlap at the other. A product score of 50 is produced either by 100% identity and 50%
overlap at one end, or 79%
identity and 100% overlap.
Alternatively, polynucleotide sequences encoding SPTM are analyzed with respect to the 2 0 tissue sources from which they were derived. Polynucleotide sequences encoding SPTM were assembled, at least in part, withoverlapping Incyte cDNA sequences. Each cDNA
sequence is derived from a cDNA library constructed from a human tissue. Each human tissue is classified into one of the following organ/tissue categories: cardiovascular system;
connective tissue; digestive system; embryonic structures; endocrine system; exocrine glands; genitalia, female; genitalia, male;
germ cells; heroic and immune system; liver; musculoskeletal system; nervous system; pancreas;
respiratory system; sense organs; skin; stomatognathic system;
unclassified/mixed; or urinary tract.
The number of libraries in each category for each polynucleotide sequence encoding SPTM is counted and divided by the total number of libraries across all categories for each polynucleotide sequence encoding SPTM. Similarly, each human tissue is classified into one of the following disease/condition s o categories: cancer, cell line, developmental, inflammation, neurological, trauma, cardiovascular, pooled, and other, and the number of libraries in each category for each polynucleotide sequence encoding SPTM is counted and divided by the total number of libraries across all categories for each polynucleotide sequence encoding SPTM. The resulting percentages reflect the tissue-specific and disease-specific expression of cDNA encoding SPTM. Percentage values of tissue-specific expression are reported in Table 4. cDNA sequences and cDNA library/tissue information are found in the LIFESEQ GOLD database (Incyte Genomics, Palo Alto CA).
s VI. Tissue Distribution Profiling A tissue distribution profile is determined for each template by compiling the cDNA library tissue classifications of its component cDNA sequences. Each component sequence, is derived from a cDNA library constructed from a human tissue. Each human tissue is classified into one of the following categories: cardiovascular system; connective tissue; digestive system; embryonic to structures; endocrine system; exocrine glands; genitalia, female;
genitalia, male; germ cells; heroic and immune system; liver; musculoskeletal system; nervous system; pancreas;
respiratory system; sense organs; skin; stomatognathic system; unclassified/mixed; or urinary tract.
Template sequences, component sequences, and cDNA library/tissue information are found in the LIFESEQ GOLD
database (Incyte Genomics, Palo Alto CA).
15 Table 4 shows the tissue distribution profile for the templates of the invention. For each template, the three most frequently observed tissue categories are shown in column 2, .along with the percentage of component sequences belonging to each category. Only tissue categories with percentage values of > 10% are shown. A tissue distribution of "widely distributed'' in column 2 indicates percentage values of <10% in all tissue categories.
VII. Transcript Image Analysis Transcript 'images are generated as described in Seilhamer et al., "Comparative Gene Transcript Analysis," U.S. Patent Number 5,840,484, incorporated herein by reference.
a s VIII. Extension of Polynucleotide Sequences and Isolation of a Full-length cDNA
Oligonucleotide primers designed using an sptm of the Sequence Listing are used to extend the nucleic acid sequence. One primer is synthesized to initiate 5' extension of the template, and the other primer, to initiate 3' extension of the template. The initial primers may be designed using OLIGO
4.06 software (National Biosciences, Inc. (National Biosciences), Plymouth MN), or another 3 o appropriate program, to be about 22 to 30 nucleotides in length, to have a GC content of about 50% or more, and to anneal to the target sequence at temperatures of about 68°C to about 72°C. Any stretch of nucleotides which would result in hairpin structures and primer-primer dimerizations are avoided. Selected human cDNA libraries are used to extend the sequence. If more than one extension is necessary or desired, additional or nested sets of primers are designed.
High fidelity amplification is obtained by PCR using methods well known in the art. PCR is performed in 96-well plates using the PTC-200 thermal cycler (MJ Research).
The reaction mix contains DNA template, 200 nmol of each primer, reaction buffer containing Mg2+, (NH4)ZS04, and 13-mercaptoethanol, Taq DNA polymerise (Amersham Pharmacia Biotech), ELONGASE
enzyme (Life Technologies), and Pfu DNA polymerise (Stratagene), with the following parameters for primer pair PCI A and PCI B: Step 1: 94°C, 3 min; Step 2: 94°C, 15 sec; Step 3: 60°C, 1 min; Step 4: 68°C, 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68°C, 5 min;
Step 7: storage at 4°C. In the alternative, the parameters for primer pair T7 and SK+ are as follows: Step 1:
94°C, 3 min; Step 2:
94 ° C, 15 sec; Step 3: 57 ° C, 1 min; Step 4: 68 ° C, 2 min; Step 5: Steps 2, 3, and 4 repeated 20 times;
Step 6: 68°C, 5 min; Step 7: storage at 4°C.
The concentration of DNA in each well is determined by dispensing 100 ~1 PICOGREEN
quantitation reagent (0.25% (v/v); Molecular Probes) dissolved in 1X Tris-EDTA
(TE) and 0.5 ~1 of undiluted PCR product into each well of an opaque fluorimeter plate (Corning Incorporated (Corning), Corning NY), allowing the DNA to bind to the reagent. The plate is scanned in a FLUOROSKAN II
(Labsystems Oy) to measure the fluorescence of the sample and to quantify the concentration of DNA. A 5 ~l to 10 ~l aliquot of the reaction mixture is analyzed by electrophoresis on a 1 % agarose mini-gel to determine which reactions are successful in extending the sequence.
The extended nucleotides are desalted and concentrated, transferred to 384-well plates, 2 o digested with CviJI cholera virus endonuclease (Molecular Biology Research, Madison WI), and sonicated or sheared prior to religation into pUC 18 vector (Amersham Pharmacia Biotech). For shotgun sequencing, the digested nucleotides are separated on low concentration (0.6 to 0.8%) agarose gels, fragments are excised, and agar digested with AGAR ACE
(Promega). Extended clones are religated using T4 lipase (New England Biolabs, Inc., Beverly MA) into pUC 18 vector (Amersham Pharmacia Biotech), treated with Pfu DNA polymerise (Stratagene) to fill-in restriction site overhangs, and transfected into competent E. coli cells. Transformed cells are selected on antibiotic-containing media, individual colonies are picked and cultured overnight at 37°C in 384-well plates in LB/2x carbenicillin liquid media.
The cells are lysed, and DNA is amplified by PCR using Taq DNA polymerise (Amersham s o Pharmacia Biotech) and Pfu DNA polymerise (Stratagene) with the following parameters: Step 1:
94°C, 3 min; Step 2: 94°C, 15 sec; Step 3: 60°C, 1 min;
Step 4: 72°C, 2 min; Step 5: steps 2, 3, and 4 repeated 29 times; Step 6: 7.2°C, 5 min; Step 7: storage at 4°C.
DNA is quantified by PICOGREEN
reagent (Molecular Probes) as described above. Samples with low DNA recoveries are reamplified using the same conditions as described above. Samples are diluted with 20%
dimethysulfoxide (1:2, vlv), and sequenced using DYENAMIC energy transfer sequencing primers and the DYENAMIC
DIRECT kit (Amersham Pharmacia Biotech) or the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems).
In like manner, the sptm is used to obtain regulatory sequences (promoters, introns, and enhancers) using the procedure above, oligonucleotides designed for such extension, and an appropriate genomic library.
IX. Labeling of Probes and Southern Hybridization Analyses to Hybridization probes derived from the sptm of the Sequence Listing are employed for screening cDNAs, mRNAs, or genomic DNA. The labeling of probe nucleotides between 100 and 1000 nucleotides in length is specifically described, but essentially the same procedure may be used with larger cDNA fragments. Probe sequences are labeled at room temperature for 30 minutes using a T4 polynucleotide kinase, y32P-ATP, and O.SX One-Phor-All Plus (Amersham Pharmacia Biotech) 15 buffer and purified using a ProbeQuant G-50 Microcolumn (Amersham Pharmacia Biotech).. The probe mixture is diluted to 10' dpm/~g/ml hybridization buffer and used in a typical membrane-based hybridization analysis.
The DNA is digested with a restriction endonuclease such as Eco RV and is electrophoresed through a 0.7% agarose gel: The DNA fragments are transferred from the agarose to nylon 20 membrane (NYTRAN Plus, Schleicher & Schuell, Inc., Keene NH) using procedures specified by the manufacturer of the membrane. Prehybridization is carried out for three or more hours at 68 °C, and hybridization is carried out overnight at 68 °C. To remove non-specific signals, blots are sequentially washed at room temperature under increasingly stringent conditions, up to O.lx saline sodium citrate (SSC) and 0.5% sodium dodecyl sulfate. After the blots are placed in a PHOSPHORIMAGER .
as cassette (Molecular Dynamics) or are exposed to autoradiography film, hybridization patterns of standard and experimental lanes are compared. Essentially the same procedure is employed when screening RNA.
X. Chromosome Mapping of sptm s o The cDNA sequences which were used to assemble SEQ ID NO:1-184 are compared with sequences from the Incyte LIFESEQ database and public domain databases using BLAST and other implementations of the Smith-Waterman algorithm. Sequences from these databases that match SEQ
B7 N0:1-184 are assembled into clusters of contiguous and overlapping sequences using assembly algorithms such as PHRAP (Table 6). Radiation hybrid and genetic mapping data available from public resources such as the Stanford Human Genome Center (SHGC), Whitehead Institute for Genome Research (WIGR)~ and Genethon are used to determine if any of the clustered sequences have been previously mapped. Inclusion of a mapped sequence in a cluster will result in the s assignment of all sequences of that cluster, including its particular SEQ ID
NO:, to that map location.
The genetic map locations of SEQ ID NO:l-184 are described as ranges, or intervals, of human chromosomes. The map position of an interval, in centiMorgans, is measured relative to the terminus of the chromosome's p-arm. (The centiMorgan (cM) is a unit of measurement based on recombination frequencies between chromosomal markers. On average, 1 cM is roughly equivalent to so 1 megabase (Mb) of DNA in humans, although this can vary widely due tohot and cold spots of recombination.) The cM distances are based on genetic markers mapped by Genethon which provide boundaries for radiation hybrid markers whose sequences were included in each of the clusters.
XI. Microarray Analysis 15 Probe Preparation from Tissue or Cell Samples Total RNA is isolated from tissue samples using the guanidinium thiocyanate method arid polyA+ RNA is purified using the oligo (dT) cellulose method. Each polyA+ RNA
sample is reverse transcribed using MMLV reverse-transcriptase, 0.05 pg/~1 oligo-dT primer (2lmer), 1X first strand buffer, 0.03 units/~1 RNase inhibitor; 500 ~M dATP, 500 ~M dGTP, 500 ~M dTTP, 40 ~M dCTP, 40 2o pM dCTP-Cy3 (BDS) or dCTP-Cy5 (Amersham Pharmacia Biotech). The reverse transcription reaction is performed in a 25 ml volume containing 200 ng polyA+ RNA with GEMBRIGHT kits (Incyte). Specific control polyA+ RNAs are synthesized by in vitro transcription from non-coding yeast genomic DNA (W. Lei, unpubfished). As quantitative controls, the control mRNAs at 0.002 ng, 0.02 ng, 0.2 ng, and 2 ng are diluted into reverse transcription reaction at ratios of 1:100,000, '1:10,000, 25 1:1000, 1:100 (w/w) to sample mRNA respectively. The control mRNAs are diluted into reverse transcription reaction at ratios of 1:3, 3:1, 1:10, 10:1, 1:25, 25:1 (w/w) to sample mRNA differential expression patterns. After incubation at 37° C for 2 hr, each reaction sample (one with Cy3 and another with Cy5 labeling) is treated with 2.5 ml of 0.5M sodium hydroxide and incubated for 20 minutes at 85° C to the stop the reaction and degrade the RNA. Probes are purified using two s o successive CHROMA SPIN 30 gel filtration spin columns (CLONTECH
Laboratories, Inc.
(CLONTECH), Palo Alto CA) and after combining, both reaction samples are ethanol precipitated using 1 ml of glycogen (1 mg/ml), 60 ml sodium acetate, and 300 ml of 100%
ethanol. The probe is then dried to completion using a SpeedVAC (Savant Instruments Inc., Holbrook NY) and resuspended in 14 ~1 SX SSC/0.2% SDS.
Microarray Preparation Sequences of the present invention are used to generate array elements. Each array element s is amplified from bacterial cells containing vectors with cloned cDNA
inserts. PCR amplification uses primers complementary to the vector sequences flanking the cDNA insert. Array elements are amplified in thirty cycles of PCR from an initial quantity of 1-2 ng to a final quantity greater than 5 ~ g.
Amplified array elements are then purified using SEPHACRYL-400 (Amersham Pharmacia Biotech).
Purified array elements are immobilized on polymer-coated glass slides. Glass microscope 1 o slides (Corning) are cleaned by ultrasound in 0.1 % SDS and acetone, with extensive distilled water washes between and after treatments. Glass slides are etched in 4%
hydrofluoric acid (VWR
Scientific Products Corporation (VWR), West Chester, PA), washed extensively in distilled water, and coated with 0.05% aminopropyl silane (Sigma) in 95% ethanol. Coated slides are cured in a 110°C
oven.
15 Array elements are applied to the coated glass substrate using a procedure described in US
Patent No. 5,807,522, incorporated herein by reference. 1 p1 of the array element DNA,. at an average concentration of 100 ng/~1, is loaded into the open capillary printing element by a high-speed robotic apparatus. The apparatus then deposits about 5 n1 of array element sample per slide.
Microarrays are UV-crosslinked using a STRATALINI~ER UV-crosslinker (Stratagene). .
2 o Microarrays are washed at room temperature once in 0.2% SDS and three times in distilled water..
Non-specific binding sites are blocked by incubation of microarrays in 0.2%
casein in phosphate buffered, saline (PBS) (Tropix, Inc., Bedford, MA) for 30 minutes at 60° C followed by washes in 0.2% SDS and distilled water as before.
2 s Hybridization Hybridization reactions contain 9 ~ul of probe mixture consisting of 0.2 yg each of Cy3 and Cy5 labeled cDNA synthesis products in SX SSC, 0.2% SDS hybridization buffer. The probe mixture is heated to 65° C for 5 minutes and is aliquoted onto the microarray surface and covered with an 1.8 cm2 coverslip. The arrays are transferred to a waterproof chamber having a cavity just slightly larger s o than a microscope slide. The chamber is kept at 100% humidity internally by the addition of 140 p l of Sx SSC in a corner of the chamber. The chamber containing the arrays is incubated for about 6.5 hours at 60° C. The arrays are washed for 10 min at 45° C in a first wash buffer (IX SSC, 0.1 %
SDS), three times for 10 minutes each at 45° C in a second wash buffer (0.1X SSC), and dried. .

Detection Reporter-labeled hybridization complexes are detected with a microscope equipped with an Innova 70 mixed gas 10 W laser (Coherent, Inc., Santa Clara CA) capable of generating spectral lines at 488 nm for excitation of Cy3 and at 632 nm for excitation of CyS. The excitation laser light is s focused on the array using a 20X microscope objective (Nikon, Inc., Melville NY). The slide containing the array is paced on a computer-controlled X-Y stage on the microscope and raster-scanned past the objective. The 1.8 cm x 1.8 cm array used in the present example is scanned with a resolution of 20 micrometers.
In two separate scans, a mixed gas multiline laser excites the two fluorophores sequentially.
to Emitted light is split, based on wavelength, into two photomultiplier tube detectors (PMT 81477, Hamamatsu Photonics Systems, Bridgewater NJ) corresponding to the two fluorophores. Appropriate filters positioned between the array and the photomultiplier tubes are used to filter the signals. The emission maxima of the fluorophores used are 565 nm for Cy3 and 650 nm for CyS. Each array is typically scanned twice, one scan per fluorophore using the appropriate filters at the laser source, is although the apparatus is capable of recording the spectra from both fluorophores simultaneously.
The sensitivity of the scans is typically calibrated using the signal intensity generated by a cDNA control species added to the probe mix at a known concentration. A
specific location on the array contains a complementary DNA sequence, allowing the intensity of the signal at that location to be correlated with a weight ratio of hybridizing species of 1:200,000. When two probes from different a o sources (e.g., representing test and control cells), each labeled with a different fluorophore, are hybridized to a single array for the purpose of identifying genes that are differentially expressed, the calibration is done by labeling samples of the calibrating cDNA with the two fluorophores and adding identical amounts of each to the hybridization mixture.
The output of the photomultiplier tube is digitized using a 12-bit RTI-835H
analog-to-digital as (A/D) conversion board (Analog Devices, Inc., Norwood, MA) installed in an IBM-compatible PC
computer. The digitized data are displayed as an image where the signal intensity is mapped using a linear 20-color transformation to a pseudocolor scale ranging from blue (low signal) to red (high signal). The data is also analyzed quantitatively. Where wo different fluorophores are excited and measured simultaneously, the data are first corrected for optical crosstalk (due to overlapping emission 3 o spectra) between the fluorophores using each fluorophore's emission spectrum.
A grid is superimposed over the fluorescence signal image such that the signal from each spot is centered in each element of the grid. The fluorescence signal within each element is then integrated to obtain a numerical value corresponding to the average intensity of the signal. The software used for signal analysis is the GEMTOOLS gene expression analysis program (Incyte).
XII. Complementary Nucleic Acids Sequences complementary to the sptm are used to detect, decrease, or inhibit expression of s the naturally occurring nucleotide. The use of oligonucleotides comprising from about 15 to 30 base pairs is typical in the art. However, smaller or larger sequence fragments can also be used.
Appropriate oligonucleotides are designed from the sptm using OLIGO 4.06 software (National Biosciences) or other appropriate programs and are synthesized using methods standard in the art or ordered from a commercial supplier. To inhibit transcription, a complementary oligonucleotide is to designed from the most unique 5' sequence and used to prevent transcription factor binding to the promoter sequence. To inhibit translation, a complementary oligonucleotide is designed to prevent ribosomal binding and processing of the transcript.
XIII. Expression of SPTM
15 Expression and purification of SPTM is accomplished using bacterial or virus-based expression systems. For expression of SPTM in bacteria, cDNA is subcloned into an appropriate vector containing an antibiotic resistance gene and an inducible promoter that directs high levels of cDNA transcription. Examples of such promoters include, but are not limited to, the trp-lac (tac) hybrid promoter and the TS or T7 bacteriophage promoter in conjunction with the lac operator 2o regulatory element. .Recombinant vectors are transformed into suitable bacterial hosts, e.g., BL21 (DE3). Antibiotic resistant bacteria express SPTM upon induction with isopropyl beta-D- ' thiogalactopyranoside (IPTG). Expression of SPTM in eukaryotic cells is achieved by infecting insect or mammalian cell lines with recombinant Auto~raphica californica nuclear polyhedrosis virus (AcMNPV), commonly known as baculovirus. The nonessential.polyhedrin gene of baculovirus is a s replaced with cDNA encoding SPTM by either homologous recombination or bacterial-mediated transposition involving transfer plasmid intermediates. Viral infectivity is maintained and the strong polyhedrin promoter drives high levels of cDNA transcription. Recombinant baculovii~us is used to infect Spodoptera fru~iperda (Sf9) insect cells in most cases, or human hepatocytes, in some cases.
Infection of the latter requires additional genetic modifications to baculovirus. (See e.g., Engelhard, s o supra; and Sandig, supra.) In most expression systems, SPTM is synthesized as a fusion protein with, e.g., glutathione S-transferase (GST) or a peptide epitope tag, such as FLAG or 6-His, permitting rapid, single-step, affinity-based purification of recombinant fusion protein from crude cell lysates. GST, a 26-kilodalton enzyme from Schistosoma japonicum, enables the purification of fusion proteins on immobilized glutathione under conditions that maintain protein activity and antigenicity (Amersham Pharmacia Bioteeh). Following purification, the GST moiety can be proteolytically cleaved from SPTM at specifically engineered sites. FLAG, an 8-amino acid peptide, enables immunoaffinity purification s using commercially, available monoclonal and polyclonal anti-FLAG antibodies (Eastman Kodak Company, Rochester NY). 6-His, a stretch of six consecutive histidine residues, enables purification on metal-chelate resins (QIAGEN). Methods for protein expression and purification are discussed in Ausubel (1995, supra, Chapters 10 and 16). Purified SPTM obtained by these methods can be used directly in the following activity assay.
XIV. Demonstration of SPTM Activity An assay for SPTM activity measures the expression of SPTM on the cell surface. cDNA
encoding SPTM is subcloned into an appropriate mammalian expression vector suitable for high levels of eDNA expression. The resulting construct is transfected into a nonhuman cell line such as NIH3T3. Cell surface proteins are labeled with biotin using methods known in the art.
Immunoprecipitations are performed using SPTM-specific antibodies, and immunoprecipitated samples are analyzed using SDS-PAGE and immunoblotting techniques. The ratio of labeled immunoprecipitant to unlabeled immunoprecipitant is proportional to the amount of SPTM expressed on the cell surface.
2 o Alternatively, an assay for SPTM activity measures the amount of SPTM in secretory, membrane-bound organelles: Transfected cells as described above are harvested and lysed. The lysate is fractionated using methods known to those of skill in the art, for example, sucrose gradient ultracentrifugation. Such methods allow the isolation of subcellular components such as the Golgi apparatus, ER, small membrane-bound vesicles, and other secretory organelles.
Immunoprecipitations as from fractionated and total cell lysates are performed using SPTM-specific antibodies, and immunoprecipitated samples are analyzed using SDS-PAGE and immunoblotting techniques: The concentration of SPTM in secretory organelles relative to SPTM in total cell lysate is proportional to the amount of SPTM in transit through the secretory pathway.
3 o XV. Functional Assays SPTM function is assessed by expressing sptm at physiologically elevated levels in mammalian cell culture systems. cDNA is subcloned into a mammalian expression vector containing a strong promoter that drives high levels of cDNA expression. 'Vectors of choice include pCMV

SPORT (Life Technologies) and pCR3.1 (Invitrogen Corporation, Carlsbad CA), both of which contain the cytomegalovirus promoter. 5-10 ~ g of recombinant vector are transiently transfected into a human cell line, preferably of endothelial or hematopoietic origin, using either liposome formulations or electroporation. 1-2 ~ g of an additional plasmid containing sequences encoding a marker protein s are co-transfected.
Expression of a marker protein provides a means to distinguish transfected cells from nontransfected cells and is a reliable predictor of cDNA expression from the recombinant vector.
Marker proteins of choice include, e.g., Green Fluorescent Protein (GFP;
CLONTECH), CD64, or a CD64-GFP fusion protein. Flow cytometry (FCM), an automated laser optics-based technique, is to used to identify transfected cells expressing GFP or CD64-GFP and to evaluate the apoptotic state of the cells and other cellular properkies.
FCM detects and quantifies the uptake of fluorescent molecules that diagnose events preceding or coincident with cell death. These events include changes in nuclear DNA content as .
measured by staining of DNA.with propidium iodide; changes in cell size and granularity as measured 15 by forward light scatter and 90 degree side light scatter; down-regulation of DNA synthesis as measured by decrease in bromodeoxyuridine uptake; alterations in expression of cell surface and intracellular proteins as measured by reactivity with specific antibodies; and alterations in plasma membrane composition as measured by the binding of fiuorescein-conjugated Annexin V protein to the cell surface. Methods. in flow cytometry are discussed in OrW erod, M. G.
(1994) Flow Cytometr~, 2 o Oxford, New York NY.
The influence of SPTM on gene expression' can be assessed using highly purified populations of cells transfected with sequences encoding SPTM and either CD64 or CD64-GFP.
CD64 and CD64-GFP are expressed on the surface of transfected cells and bind to conserved regions of human immunoglobulin G (IgG). Transfected cells are efficiently separated from nontransfected cells using as magnetic beads coated with either human IgG or antibody against CD64 (DYNAL, Inc., Lake Success NY). mRNA can be purified from the cells using methods well known by those of skill in the art. Expression of mRNA encoding SPTM and other genes of interest can be analyzed by northern analysis or microarray techniques.
3 o XVI. Production of Antibodies SPTM substantially purified using polyacrylamide gel electrophoresis (PAGE;
see, e.g., Harrington, M.G. (1990) Methods Enzymol. 182:488-495), or other purification techniques, is used to immunize rabbits and to produce antibodies using standard protocols.

Alternatively, the SPTM amino acid sequence is analyzed using LASERGENE
software (DNASTAR) to determine regions of high immunogenicity, and a corresponding peptide is synthesized and used to raise antibodies by means known to those of skill in the art.
Methods for selection of appropriate epitopes, such as those near the C-terminus or in hydrophilic regions are well described in s the art. (See, e.g., Ausubel, 1995, supra, Chapter 11.) Typically, peptides 15 residues in length are synthesized using an ABI 431A
peptide synthesizer (Applied Biosystems) using fmoc-chemistry and coupled to I~LH
(Sigma) by reaction with N-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) to increase immunogenicity. (See, e.g.;
Ausubel, supra.) Rabbits are immunized with the peptide-KLH complex in complete Freund's to adjuvant. Resulting antisera are tested for antipeptide activity by, for example, binding the peptide to plastic, blocking with 1 % BSA, reacting with rabbit antisera, washing, and reacting with radio-iodinated goat anti-rabbit IgG. Antisera with antipeptide activity are tested for anti-SPTM activity using protocols well known in the art, including ELISA, RIA, and immunoblotting.
15 XVII. Purification of Naturally Occurring SPTM Using Specific Antibodies Naturally occurring or recombinant SPTM is substantially purified by immunoaffinity chromatography using antibodies specific for SPTM. An immunoaffinity column is constructed by covalently coupling anti-SPTM antibody to an activated chromatographic resin, such as CNBr=activated SEPHAROSE (Amersham Pharmacia Biotech). After the coupling, the resin is 2 o blocked and washed according to the manufacturer's instructions.
Media containing SPTM are passed over the immunoaffinity column, and the column is washed under conditions that allow the preferential absorbance of SPTM (e.g., high ionic strength buffers in the presence of detergent). The column is eluted under conditions that disrupt antibody/SPTM binding (e.g., a buffer of pH 2 to pH 3, or a high concentration of a chaotrope, such as 2 s urea or thiocyanate ion), and SPTM is collected.
XVIII. Identification of Molecules Which Interact with SPTM
SPTM, or biologically active fragments thereof, are labeled with lzsI Bolton-Hunter reagent.
(See, e.g., Bolton, A.E. and W.M. Hunter (1973) Biochem. J. 133:529-539.) Candidate molecules 3 o previously arrayed in the wells of a multi-well plate are incubated with the labeled SPTM, washed, and any wells with labeled SPTM complex are assayed. Data obtained using different concentrations of SPTM are used to calculate values for the number, affinity, and association of SPTM with the candidate molecules.

Alternatively, molecules interacting with SPTM are analyzed using the yeast two-hybrid system as described in Fields, S. and O. Song (1989) Nature 340:245-246, or using commercially available kits based on the two-hybrid system, such as the MATCHMAKER system (CLONTECH).
SPTM may also be used in the PATHCALLING process (CuraGen Corp., New Haven CT) s which employs the yeast two-hybrid system in a high-throughput manner to determine all interactions between the proteins encoded by two large libraries of genes (Nandabalan, K.
et al. (2000) U.S.
Patent No. 6,057,101).
All publications and patents mentioned in the above specification are herein incorporated by to reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention.
Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the is invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims.

SEQ ID Template ID SEQ ID ORF ID
NO; NO:

1 LG:983076.3:2000SEP08185 LG:983076.3.orf3:2000SEP08 2 LG:1382987.7:2000SEP08186 LG;1382987.7.orf2:2000SEP08 3 LG:235557.15:2000SEP08187 LG:235557.15,orf2;2000SEP08 4 LG;018494.1:2000SEP08188 LG:018494.1.orf2:2000SEP08 LG;980494.1:2000SEP08189 LG:980494.1.orf3:2000SEP08 b LG;984457.2:2000SEP08190 LG:984457.2.orf1:2000SEP08 7 LG;406758.1;2000SEP08191 LG;40b758.1.orf1;2000SEP08 8 LG;902957.17;2000SEP08192 LG;902957.17.orf3:2000SEP08 9 LG:333 T 79. T 193 LG:333179. T .ort3;2000SEP08 ;2000SEP08 LG;4065b8.1:2000SEP08194 LG;4065b8.1.orf2:2000SEP08 11 LG;353203.1:2000SEP08195 LG:353203.1.orf1:2000SEP08 12 LG;061277.1;2000SEP08196 LG;ObI 277.1.orf3;2000SEP08 13 LG:170666.1:2000SEP08197 LG:170b66.1.orf2:2000SEP08 14 LG:311197.1:2000SEP08198 LG;311197.1.orf2;2000SEP08 LG:220655.4:2000SEP08199 LG:220b55.4.orf2:2000SEP08 T 6 LG;1001893.1;2000SEP08200 LG; i 00 T 893, i .orf2:2000SEP08 17 LG:004335.1:2000SEP08201 LG:004335.1.orf1:2000SEP08 18 LG:213092.6:2000SEP08202 LG:213092.b.orf2:2000SEP08 19 LG:407570.5;2000SEP08203 LG:407570.5.orf3;2000SEP08 LG;337835.8:2000SEP08204 LG;337835.8.orf1;2000SEP08 21 LG;1099283.1;2000SEP08205 LG:1099283.1.orf2;2000SEP08 22 LG;401274.2;2000SEP08206 LG;401274.2.orf2;2000SEP08 23 LG;222880.1:2000SEP08207 LG;222880.1.orf3;2000SEP08 24 LG:406389.1:2000SEP08208 LG;406389.1.orf1:2000SEP08 LG:055461.7 ;2000SEP08209 LG:055467.1.orf2:2000SEP08 26 LG:979059.5:2000SEP08210 LG:979059.5.orf1:2000SEP08 27 LG;399238.1;2000SEP08211 LG;399238.1.orf1:2000SEP08 28 LG:1382945.7;2000SEP08212 LG:1382945.7.orf1:2000SEP08 29 LG:1383b10.3;2000SEP08213 LG:1383610.3.orf2:2000SEP08 LG:1384030.1;2000SEP08214 LG;1384030.1.orf3;2000SEP08 31 LG:390475.1:2000SEP08215 LG;390475.1.orf1:2000SEP08 32 LG;229105.3:2000SEP08216 LG:229105.3.orf2;2000SEP08 33 LG:232578.3;2000SEP08217 LG;232578.3.orf1:2000SEP08 34 LG;1166387.9:2000SEP08218 LG:1166387.9.orf1:2000SEP08 LG:351357.1;2000SEP08219 LG:351357.1.orf1:2000SEP08 36 LG:465592.1:2000SEP08220 LG;465592.1.orf1:2000SEP08 37 LG:OOb848.5:2000SEP08221 LG:OOb848.5.orf1;2000SEP08 38 LG;198450.2;2000SEP08222 LG:198450.2.orf2:2000SEP08 39 LG:1008175.1:2000SEP08223 LG:1008175.1.orf1;2000SEP08 LG:437981.11:2000SEP08224 LG;437981.11.orf2;2000SEP08 41 LG;1025549.1;2000SEP08225 LG:1025549.1.orf3:2000SEP08 42 LG;327226.16:2000SEP08226 LG:327226.1 b.orfl ;2000SEP08 43 LG:1387394.5;2000SEP08227 LG:1387394.5.orf3;2000SEP08 44 LG:445188.3:2000SEP08228 LG;445i88.3.ort3;2000SEP08 LG;898864.11:2000SEP08229 LG;898864.11.orf3:2000SEP08 46 LG:0T8739.2:2000SEP08230 LG:018739.2.orf1;2000SEP08 ' 47 LG:302915.6:2000SEP08231 LG:302915.b.orf3:2000SEP08 48 LG:404418.3;2000SEP08232 LG;404418.3.orf1;2000SEP08 49 LG:374853.2:2000SEP08233 LG;374853.2.orf1:2000SEP08 LG:228930.1:2000SEP08234 LG:228930.1.ort2:2000SEP08 SEQ ID Template ID SEQ ID ORF ID
NO; NO:

51 LG:273593.6;2000SEP08235 LG:273593.b.orf1;2000SEP08 52 LG:008215.1;2000SEP08236 LG;008215.1.orf3;2000SEP08 53 LG:337160.1:2000SEP08237 LG;337160.1.orf1:2000SEP08 54 LG:3950b3.1;2000SEP08238 LG:3950b3, l .orf3:2000SEP08 55 LG;979069.4:2000SEP08239 LG:979069.4.orf1:2000SEP08 56 LG:346663.5:2000SEP08240 LG;346663.5.orf3:2000SEP08 57 LG:347b15.1:2000SEP08241 LG:347615.1.orf3:2000SEP08 58 LG:1397067.1;2000SEP08242 LG:1397067, l .orf1;2000SEP08 59 LG:120b75.1:2000SEP08243 LG;120675.1.orf1;2000SEP08 b0 LG;420050.18;2000SEP08244 LG;420050.18.orf3;2000SEP08 61 LG:220495.3;2000SEP08245 LG;220495.3.orf1:2000SEP08 b2 LG;274551.1:2000SEP08246 LG:274551.l .orf1;2000SEP08 63 LG:429658.27:2000SEP08247 LG;429658.27.orf2:2000SEP08 64 LG;246194.18:2000SEP08248 LG;246194.18.orf1;2000SEP08 65 LG:000874.1:2000SEP08249 LG:000874, l .orf1;2000SEP08 bb LG:2399b7.7:2000SEP08250 LG:239967.7.orf1:2000SEP08 67 LG:238388.1:2000SEP08~ 251 LG:238388.1.orf3;2000SEP08 b8 LG:233674.4:2000SEP08252 LG:233674.4.orf1:2000SEP08 69 LG;411327.2:2000SEP08253 LG:411327.2.orf3;2000SEP08 70 LG:1327310.1:2000SEP08254 LG;1327310, l .orf1:2000SEP08 71 LG;242019.13:2000SEP08255 LG:242019.13.orf2;2000SEP08 72 LG:012432.12;2000SEP08256 LG:012432.12.orf1;2000SEP08 73 LG;257088.9:2000SEP08257 LG:257088.9.orf3;2000SEP08 74 LG;997505.5:2000SEP08258 LG:997505.5.orf2;2000SEP08 75 LG:48143b.2:2000SEP08259 LG:481436.2.orf3:2000SEP08 76 LG:247776.14:2000SEP08260 LG;24777b.14.orf1:2000SEP08 77 LG;008606.14;2000SEP08261 LG:008606.14.orf2:2000SEP08 78 LG:985092.3:2000SEP082b2 LG:985092.3.orf2:2000SEP08 79 LG;236649.7;2000SEP08263 LG:236649.7.orf2:2000SEP08 80 LG:245014.2:2000SEP08264 LG;245014.2.orf1:2000SEP08 81 LG:170754.4:2000SEPOB265 LG:170754.4.orf2;2000SEP08 82 LG;988028.1;2000SEP08266 LG;988028.1.orfl :2000SEP08 83 LG:427997.6:2000SEP082b7 LG;427997,b.orf3;2000SEP08 84 LG;464206.1:2000SEP08268 LG;464206.1.orf2;2000SEP08 85 LG:1400108.1:2000SEP08269 LG;1400108.1.orf3:2000SEP08 86 LG:254531.1:2000SEP08270 LG:254531.1.orf1:2000SEP08 87 LG:I 101317.1;2000SEP08271 LG:1101317.l .orf1;2000SEP08 88 LG;1074728.6;2000SEP08272 LG;1074728.6.orf1;2000SEP08 89 LG:1081684.1:2000SEP08273 LG;1081684. l .orf3:2000SEP08 90 LG:1076520.1:2000SEP08274 LG;1076520.1.orf1;2000SEP08 91 LG:1079477.1:2000SEP08275 LG:1079477.1.orf2:2000SEP08 92 LG;1076269.1:2000SEP08276 LG;1076269.1.orf2;2000SEP08 93 LG:1087195.1;2000SEP08277 LG;1087195.1.orf3:2000SEP08 94 LG:002588.7:2000SEP08278 LG;002588.7.orf2;2000SEP08 95 LG:1079470.6:2000SEP08279 LG:1079470.6.orf1;2000SEP08 96 LG;345705.3;2000SEP08280 LG:345705.3.orf1:2000SEP08 97 LG:1083654.1;2000SEP08281 LG:1083654.1.orfl ;2000SEP08 98 LG:198782.3;2000SEP08282 LG;198782.3.orfl ;2000SEP08 99 LG:981076.2:2000SEP08283 LG:981076.2.orf1:2000SEP08 100 LG:212023.3:2000SEP08284 LG;212023.3.orf3:2000SEP08 SEQ ID Template ID SEQ ID ORF ID
NO: NO:

101 LG:977929.3:2000SEP08285 LG:977929.3.orf3;2000SEP08 102 LG:201936.b:2000SEP08286 LG:201936.b.ort2:2000SEP08 103 LG:205b42.1;2000SEP08287 LG:205642.1.orf3;2000SEP08 104 LG:339653.b:2000SEP08288 LG:339653.b.orf3:2000SEP08 105 LG:978587.4:2000SEP08289 LG:978587.4.orf1:2000SEP08 106 LG:216848.17:2000SEP08290 LG:216848.17.ort1:2000SEP08 107 LG;219502.1:2000SEP08291 LG:219502.1.orf2:2000SEP08 108 LI:334211.1;2000SEP08292 LI:334211.1.orf2:2000SEP08 109 LI:231024.2:2000SEP08293 LI:231024.2.orf3:2000SEP08 110 LI;228425.5;2000SEP08294 LI:228.425.5.orf2:2000SEP08 1 i 1 LI:034493.1;2000SEP08295 LI:034493.1.orf3:2000SEP08 112 LI:33b218.1;2000SEP08296 LI;33b218.1.orf2;2000SEP08 113 LI:235891.3:2000SEP08297 LI:235891.3.orf1;2000SEP08 114 LI:344094.1;2000SEP08298 LI:344094.1.orf2:2000SEP08 115 LI:399945.2:2000SEP08299 LI;399945.2.orf3;2000SEP08 116 LI;051849.1:2000SEP08300 LI:051849.1.orf1:2000SEP08 117 LI:238379.3:2000SEP08301 LI;238379.3.orf2:2000SEP08 118 LI;352190.8:2000SEP08302 LI:352190.8.orfi3;2000SEP08 119 LI;432120.1;2000SEP08303 LI;432120.1.orf2;2000SEP08 120 LI;0554b1.1:2000SEP08304 LI:0554b1.1.orf2:2000SEP08 121 LI:197433.5:2000SEP08305 LI;197433.5.orf1:2000SEP08 122 LI:170b04.1;2000SEP08306 LI:170b04.1.orf2;2000SEP08 123 LI:205057.3:2000SEP08307 LI:205057.3.orf2;2000SEP08 124 LI:233795.1:2000SEP08308 LI:233795, l .orf1;2000SEP08 125 LI;311197.1;2000SEP08309 LI;3i 1197.1.orf2:2000SEP08 126 LI:441364.1;2000SEP08310 LI:4413b4.1.orf3;2000SEP08 127 LI:2103b7.6:2000SEP08311 LI;210367.b.orf3;2000SEP08 128 LI:238194.5;2000SEP08312 LI:238194.5.ort3:2000SEP08 129 LI;039258.5:2000SEP08313 LI:039258.5.orf1;2000SEP08 130 LI:1071842.1:2000SEP08314 LI:1071842.1.orf2;2000SEP08 131 LI;481356.3;2000SEP08315 LI;481356.3.orf2:2000SEP08 132 LI;103474.1:2000SEP08316 LI:103474.1.orf3;2000SEP08 133 LI;1073020.10:2000SEP08317 LI:1073020.10.orf2:2000SEP08 134 LI;000874.1:2000SEP08318 LI:000874.1.orf1;2000SEP08 135 LI:037298.2;2000SEP08319 LI:037298.2.orf1;2000SEP08 136 LI;422901.1;2000SEP08320 LI:422901.l .orf1:2000SEP08 137 LI;345815.1;2000SEP08321 LI:345815.1.orf2:2000SEP08 138 LI:1072014.2:2000SEP08322 LI:1072014.2.orf3:2000SEP08 139 LI:333138,3;2000SEP08323 LI:333138.3.orf3;2000SEP08 140 LI:414253.1:2000SEP08324 LI:414253.1.orf3;2000SEP08 141 LI;406389.1;2000SEP08325 LI:406389.1.orf1;2000SEP08 142 LI:108b171.1:2000SEP08326 LI:108b171.l.orf1;2000SEP08 143 LI:198782.4:2000SEP08327 LI:198782.4.orf3:2000SEP08 144 LI:2030279.1:2000SEP08328 LI:2030279.1.orf2;2000SEP08 145 LI;1 Ol 8424.3:2000SEP08329 LI:1 Ol 8424.3.orf2;2000SEP08 146 LI:1309b9.1;2000SEP08330 LI:1309b9.1.orf3:2000SEP08 147 LI:28b246.2;2000SEP08331 LI:28b246.2.orf1;2000SEP08 148 LI:001527.1;2000SEP08332 LI:001527.1.orf2:2000SEP08 149 LI;395063.1:2000SEP08333 LI:395063.1.orf1:2000SEP08 150 LI:1064460,1:2000SEP08334 LI:10644b0.1.orf1:2000SEP08 TABLE T
SEQ ID Template ID SEQ ID ORF ID
NO: NO;

151 LI:344b90.2:2000SEP08335 LI:344b90.2,orf1:2000SEP08 152 LI:061585.4:2000SEP08336 LI:Ob1585.4.orf3;2000SEP08 153 LI:378428.1:2000SEP08337 LI:378428.1.orf1:2000SEP08 154 LI:474108.2;2000SEP08338 LI:474108,2,orf3;2000SEP08 155 LI:23071 T ,2:2000SEP08339 LI:23071 T ,2.orf1:2000SEP08 156 LI;008942.1:2000SEP08340 LI:008942.1,orf1;2000SEP08 157 LI:732479.1:2000SEP08341 LI:732479.1.orf3:2000SEP08 158 LI:1190250,1:2000SEP08342 LI:1190250,1.orf3;2000SEP08 159 LI;1013717.1:2000SEP08343 LI:1013717.l .orf1:2000SEP08 160 LI:2049T25,2:2000SEP08344 LI;2049125,2.orf1:2000SEP08 161 LI:1092360.1:2000SEP08345 LI:1092360.1.orf3:2000SEP08 162 LI:791524,1;2000SEP08346 LI:791524.1,orf2;2000SEP08 163 LI;1084555.3:2000SEP08347 LI:1084555,3,orf1;2000SEP08 164 LI:815418,2:2000SEP08348 LI:815418.2,orf1:2000SEP08 165 LI:416766.1:2000SEP08349 LI:41 6766. l .orf1:2000SEP08 166 Ll: l T 71008.2:2000SEP08350 LI:1171008.2.orf1:2000SEP08 167 LI:1169888,3:2000SEP08351 LI:1169888.3,orf2:2000SEP08 1 b8 LI:412592.1:2000SEP08352 LI;412592.1,orf3:2000SEP08 169 LI;349808,1:2000SEP08353 LI:349808.1.orf3:2000SEP08 170 LI:349164.2:2000SEP08354 LI:349164,2.ort3:2000SEP08 171 LI;205413,1:2000SEP08' 355 LI;205413.1,orf2:2000SEP08 172 LI:2051508,2:2000SEP08356 LI:2051508.2.orf1:2000SEP08 173 LI:34b242,2;2000SEP08357 LI;346242,2,orf2;2000SEP08 174 LI:2052717,1;2000SEP08358 LI;2052717.1,orf2:2000SEP08 175 LI:40bb68,2:2000SEP08359 LI;4066b8.2,ort2:2000SEP08 175 LI:406668.2:2000SEP08360 LI:40b668,2.orf3:2000SEP08 176 LI;1178352,1:2000SEP08361 LI:1178352. l .orf1;2000SEP08 177 LI:8140T4,7:2000SEP08362 LI:814014.7.orf1;2000SEP08 i 78 Li;1170624,1:2000SEP08363 LI: i 170b24,1.orf2:2000SEP08 179 LI:1183171,1;2000SEP08364 LI;1183171. l ,orf3:2000SEP08 180 LI:1093491,1:2000SEP08365 LI;1093491.1.orfl :2000SEP08 181 LI:046515.5:2000SEP08366 LI;046515.5,orf2;2000SEP08 182 LI;400171.2:2000SEP08367 LI;400171,2.orf3;2000SEP08 183 LI:3309T9,b:2000SEP08368 LI:3309i9,6,orf3;2000SEP08 184 LI;219502,1:2000SEP08369 LI;219502.1,orf3:2000SEP08 SEQ ID Template ID StartStop Frame Domain TypeTopology NO:

1 LG:983076.3:2000SEP08775 861 forwardTM N out 1 LG;983076.3:2000SEP08479 565 forwardTM N in 1 LG;983076.3:2000SEP08707 793 forwardTM N in 1 LG:983076.3:2000SEP08114 200 forwardTM N out 1 LG;98307b.3:2000SEP08261 317 forwardTM N out 1 LG:983076.3:2000SEP08501 587 forwardTM N out 1 LG;983076.3:2000SEP08738 794 forwardTM N out 2 LG;1382987.7:2000SEP0828 102 forwardTM N out 3 LG:235557.15:2000SEP0855 141 forwardTM N in 3 LG;235557.15;2000SEP0856 118 forwardTM N in 3 LG:235557.15:2000SEP08149 211 forwardTM N in 3 LG:235557.15:2000SEP0833 95 forwardTM N in 3 LG:235557.15:2000SEP08135 197 forwardTM N in 4 LG:018494.1;2000SEP08175 243 forwardTM N in 4 LG:018494.1:2000SEP08298 360 forwardTM N in 4 LG;018494.1:2000SEP08370 432 forwardTM N in 4 LG:018494.1:2000SEP08460 546 forwardTM N in 4 LG;018494.1;2000SEP0829 115 forwardTM N out 4 LG:018494.1;2000SEP08188 274 forwardTM N out 4 LG:018494.1:2000SEP08347 409 forwardTM N out 4 LG:018494.1:2000SEP08.446508 forwardTM N out 4 LG;018494.1:2000SEP0824 101 forwardTM N in 4 LG:018494.1;2000SEP08345 431 forwardTM N in 4 LG;018494.1:2000SEP08453 509 forwardTM N in 4 LG;018494.1;2000SEP08567 653 forwardTM N in LG:980494.1;2000SEP08304 357 forwardTM N in 5 LG:980494.1:2000SEP0812671335 forwardTM N in 5 LG:980494.1:2000SEP0813391410 forwardTM N in 5 LG;980494.1;2000SEP0814531524 forwardTM N in 5 LG:980494.1:2000SEP0815641611 forwardTM N in ' 1 5 LG:980494.1;2000SEP08563 628 forwardTM N out 5 LG:980494.1:2000SEP0813641450 forwardTM N out 5 LG:980494.1:2000SEP0815 101 forwardTM N in 5 LG:980494.1:2000SEP08855 941 forwardTM N in 5 LG:980494.1:2000SEP0812511337 forwardTM N in 5 LG:980494.1;2000SEP0813741424 forwardTM N in 5 LG:980494.1:2000SEP0814701523 forwardTM N in 6 LG;984457.2:2000SEP08418 504 forwardTM N out b LG:984457.2:2000SEP08658 738 forwardTM N out b LG:984457.2:2000SEP08889 975 forwardTM N out 6 LG:984457.2:2000SEP0811261188 forwardTM N out 6 LG;984457.2:2000SEP08765 836 forwardTM N in 7 LG:406758.1;2000SEP0810721146 forwardTM N out 7 LG:406758.1:2000SEP0812281314 forwardTM N out 7 LG:40b758.1:2000SEP08767 847 forwardTM N in 7 LG:40b758.1:2000SEP0866 119 forwardTM N out 7 LG:406758.1;2000SEP08753 824 forwardTM N out 7 LG:406758.1;2000SEP08849 911 forwardTM N out _ -~ . 3 __ SEQ ID Template ID StartStop Frame Domain TypeTopology NO;

7 LG:40b758.1:2000SEP08T T forwardTM N out T

8 LG;902957.17:2000SEP08145 216 forwardTM N out 8 LG:902957.17;2000SEP08lbl 232 forwardTM N out 8 LG;902957.17;2000SEP0818 77 forwardTM N out 8 LG:902957.17;2000SEP08132 218 forwardTM N out 9 LG:333179.1:2000SEP08109 171 forwardTM N out 9 LG:333179.1:2000SEP08211 273 forwardTM N out 9 LG;333179.1:2000SEP08334 381 forwardTM N out 9 LG;333179.1;2000SEP08600 647 forwardTM N out LG:40b568.1:2000SEP0819342017 forwardTM N out 10 LG;406568.1:2000SEP0820932173 forward~ TM N out 10 LG:406568.1;2000SEP08T 59 forwardTM N out 10 LG;4065b8.1:2000SEP08498 557 forwardTM N out 10 LG;406568.1;2000SEP081740.T826forwardTM N out 10 LG:4065b8.1;2000SEP0818331907 forwardTM N out 10 LG:406568.1:2000SEP0819262012 forwardTM N out 11 LG:353203.1:2000SEP0895 151 forwardTM N in 12 LG;Ob1277.1:2000SEP08217 303 forwardTM N out 13 LG:170666.1;2000SEP0884 134 forwardTM N out 14 LG:311197.1:2000SEP08241 315 forwardTM N in 14 LG;311197.1:2000SEP08527 613 forwardTM N out LG;220655.4:2000SEP08200 2b8 forwardTM N in 15 LG:220b55.4:2000SEP08341 403 forwardTM N in 15 LG:220655.4;2000SEP08198 284 forwardTM N out 15 LG;220b55.4;2000SEP08675 722 forwardTM N out 16 LG:1001893.1:2000SEP08370 447 forwardTM N out 16 LG:1001893.1:2000SEP08463 534 forwardTM N out 16 LG:1001893.1:2000SEP08405 491 forwardTM N in 16 LG:1001893.1;2000SEP08666 752 forwardTM N in 17 LG:004335.1:2000SEP08607 660 forwardTM N in 17 LG:004335.1;2000SEP08877 9b3 forwardTM N in T 7 LG;004335.1:2000SEP0814021485 forwardTM N in 17 LG:004335.1:2000SEP0814921578 forwardTM N in T 7 LG;004335.1;2000SEP0817831839 forwardTM N in 17 LG:004335.1:2000SEP0821672253 forwardTM N in 17 LG;004335.1;2000SEP0812981384 forwardTM N in 17 LG:004335.1:2000SEP0814151486 forwardTM N in 17 LG:004335.1;2000SEP0823002386 forwardTM N in 17 LG:004335.1:2000SEP0811851241 forwardTM N out 17 LG;004335.1;2000SEP0814161502 forwardTM N out 17 LG:004335.1;2000SEP0816201685 forwardTM N out 17 LG;004335.1:2000SEP0818421925 forwardTM N out 17 LG;004335.1;2000SEP0823162393 forwardTM N out 18 LG:213092.b;2000SEP08217 303 forwardTM N out 19 LG:407570.5:2000SEP08433 519 forwardTM N in 19 LG;407570.5:2000SEP0811 85 forwardTM N out 19 LG;407570.5;2000SEP08440 493 forwardTM N out 19 LG:407570.5:2000SEP08569 625 forwardTM N out - _ _ 2 .-. _ SEQ ID Template ID StartStopFrame Domain Topology NO: Type 19 LG;407570.5:2000SEP08414 500 forwardTM N out 20 LG:337835.8:2000SEP0870 141 forwardTM N out 21 LG:1099283.1:2000SEP0856 133 forwardTM N in 21 LG:1099283.1:2000SEP08173 259 forwardTM N in 22 LG;401274.2:2000SEP08292 348 forwardTM N in 23 LG:222880.1:2000SEP08211 297 forwardTM

23 LG:222880.1:2000SEP081714 1788forwardTM

23 LG;222880.1:2000SEP081813 1899forwardTM

23 LG:222880.1:2000SEP081930 2013forwardTM

23 LG;222880.1:2000SEP082068 2133forwardTM

23 LG:222880.1;2000SEP081b67 1753forwardTM N out 23 LG;222880.1;2000SEP081805 18b7forwardTM N out 23 LG:222880.1;2000SEP081910 1972forwardTM N out 23 LG:222880.1:2000SEP082273 2320forwardTM N out 23 LG:222880.1;2000SEP08423 485 forwardTM N in 23 LG:222880.1:2000SEP08504 566 forwardTM N in 23 LG:222880.1;2000SEP08609 689 forwardTM N in 23 LG:222880.1;2000SEP08696 782 forwardTM N in 23 LG:222880.1:2000SEP08873 959 forwardTM N in 23 LG:222880.1:2000SEP081014 1076forwardTM N in 23 LG:222880.1:2000SEP081104 1166forwardTM N in 23 LG:222880.1:2000SEP081542 1628forwardTM N in 23 LG:222880.1;2000SEP081689 1772forwardTM N in 23 LG:222880.1:2000SEP081938 2024forwardTM N in 23 LG;222880,1;2000SEP082313 2393forwardTM N in 24 LG:406389.1:2000SEP0897 171 forwardTM N in 24 LG;40b389.1;2000SEP08481 5b7 forwardTM N in 24 LG:406389.1:2000SEP08574 660 forwardTM N in 24 LG:40b389.1;2000SEP081517 1585forwardTM N out 24 LG:406389.1:2000SEP08690 758 forwardTM N in 24 LG:40b389.1:2000SEP081485 1565forwardTM N in 25 LG:055461.1:2000SEP08322 408 forwardTM N in 25 LG:055461.1:2000SEP08131 193 forwardTM N out 25 LG:055461.1:2000SEP08227 289 forwardTM N out 25 LG:055461.1:2000SEP08650 709 forwardTM N out 25 LG:055461.1:2000SEP081400 1462forwardTM N out 25 LG;055461.1:2000SEP08117 200 forwardTM N out 25 LG:055461.1:2000SEP08324 383 forwardTM N out 25 LG:055461.1;2000SEP081326 1397forwardTM N out 26 LG:979059.5:2000SEP08448 522 forwardTM N out 27 LG:399238.1:2000SEP08280 342 forwardTM N in 27 LG:399238.1:2000SEP08370 432 forwardTM N in 27 LG;399238.1;2000SEP08469 531 forwardTM N in 27 LG:399238.1:2000SEP08550 612 forwardTM N in 27 LG;399238,1:2000SEP08658 744 forwardTM N in 27 LG:399238.1;2000SEP081559 1645forwardTM N out 27 LG:399238.1:2000SEP08177 230 forwardTM

27 LG;399238.1;2000SEP081551 1637forwardTM

SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 28 LG:1382945.7:2000SEP0873 159 forwardTM N in ) 28 LG;1382945.7;2000SEP08229 303 forwardTM N in 28 LG:1382945.7:2000SEP0877 139 forwardTM N out 28 LG;1382945.7;2000SEP08152 214 forwardTM N out 28 LG:1382945.7:2000SEP08251 319 forwardTM N out 28 LG;1382945.7;2000SEP0866 152 forwardTM N out 28 LG:1382945.7:2000SEP08237 296 forwardTM N out 29 LG:1383b10.3:2000SEP08565 624 forwardTM N out 29 LG:1383b10.3:2000SEP08916 993 forwardTM N out 29 LG;1383610.3:2000SEP081126 1197forwardTM N out 29 LG:1383610.3:2000SEP081471 1557forwardTM N out 29 LG;1383610.3:2000SEP081861 1923forwardTM N out 29 LG;1383610.3:2000SEP081969 2031forwardTM N out 29 LG:1383610.3:2000SEP082053 2121forwardTM N out 29 LG:1383b10.3;2000SEP082185 2247forwardTM N out 29 LG;1383610.3;2000SEP082275 2337forwardTM N out 29 LG:1383610.3:2000SEP082365 2427forwardTM N out 29 LG:1383610.3:2000SEP081460 1546forwardTM

29 LG:1383610.3:2000SEP081658 1744forwardTM

29 LG;1383610.3:2000SEP081832 1918forwardTM

29 LG:1383610.3;2000SEP081934 1996forwardTM

29 LG:1383610.3:2000SEP082021 2083forwardTM

29 LG:1383610.3;2000SEP082153 2239forwardTM

29 LG:1383610.3:2000SEP082309 2371forwardTM

29 LG:1383610.3;2000SEP082399 2461forwardTM

29 LG:1383610.3:2000SEP08192 278 forwardTM N out 29 LG:13836 i 0.3;2000SEP08i i forwardTM N out 29 LG;1383b10.3:2000SEP081824 1889forwardTM N out 29 LG:1383610.3;2000SEP081926 2012forwardTM N out 29 LG:1383610.3:2000SEP082067 2153forwardTM N out 29 LG;1383610.3;2000SEP082187 2273forwardTM N out 29 LG;1383610.3:2000SEP082319 2405forwardTM N out 30 LG:1384030.1:2000SEP08370 420 forwardTM N out 30 LG:1384030. i 820 870 forwardTM N out ;2000SEP08 1 30 ~LG:1384030.1;2000SEP081069 1155forwardTM N out 30 LG:1384030.1:2000SEP081252 1308forwardTM N out 30 LG:1384030.1:2000SEP081396 1470forwardTM N out 30 LG:1384030.1;2000SEP081561 1632forwardTM N out 30 LG:1384030.1:2000SEP081810 1896forwardTM N out 30 LG:1384030.1;2000SEP082203 2286forwardTM N out 30 LG:1384030. i 83 1 forwardTM N in :2000SEP08 b0 2 30 LG;1384030.1:2000SEP081046 1120forwardTM N in 30 LG:1384030.1:2000SEP081145 1219forwardTM N in 30 LG;1384030.1;2000SEP081376 1462forwardTM N in 30 LG:1384030.1:2000SEP081796 1882forwardTM N in 30 LG;1384030.1;2000SEP082003 2089forwardTM N in 30 LG:1384030.1:2000SEP08924 1007forwardTM

30 LG:1384030.1:2000SEP081083 1169forwardTM
_ . 3 __-_ SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 30 LG:1384030.1:2000SEP081185 1271forwardTM

30 LG;1384030.1;2000SEP081419 1505forwardTM

30 LG:1384030.1:2000SEP081572 1658forwardTM

30 LG:1384030.1;2000SEP081878 19b4forwardTM

30 LG;1384030.1:2000SEP082079 2144forwardTM

31 LG:390475.1;2000SEP08559 621 forwardTM N in 31 LG:390475.1;2000SEP081648 1704forwardTM N in 31 LG;390475.1;2000SEP08542 592 forwardTM N out 31 LG:390475.1;2000SEP08935 1021forwardTM N out 31 LG:390475.1;2000SEP081217 1291forwardTM N out 31 LG;390475.1:2000SEP08600 686 forwardTM

31 LG;390475.1:2000SEP081053 1103forwardTM

31 LG:390475.1;2000SEP081182 1268forwardTM

32 LG:229i05.3:2000SEP08592 642 forwardTM N out 32 LG;229105.3;2000SEP08578 664 forwardTM N out 33 LG:232578.3:2000SEP081 228 forwardTM N in b3 1 33 LG:232578.3;2000SEP08226 276 forwardTM N in 33 LG:232578.3;2000SEP08295 375 forwardTM N in 33 LG;232578.3:2000SEP081042 1119forwardTM N in 33 LG;232578.3:2000SEP08155 241 forward' TM N in 33 LG:232578.3;2000SEP08308 376 forwardTM N in 33 LG:232578.3:2000SEP08599 685 forwardTM N in 33 LG:232578.3:2000SEP08704 781 forwardTM N in 33 LG;232578.3:2000SEP08998 1084forwardTM N in 33 LG:232578.3:2000SEP081154 1240forwardTM N in 33 LG:232578.3:2000SEP081 239 forwardTM N in b5 3 33 LG:232578.3;2000SEP08327 398 forwardTM N in 33 LG:232578.3;2000SEP08597 647 forwardTM N in 33 LG;232578.3;2000SEP08720 770 forwardTM N in 33 LG;232578.3;2000SEP081008 1094forwardTM N in 33 LG:232578.3;2000SEP081128 1214forwardTM N in 34 LG:1166387.9;2000SEP08565 615 forwardTM N out 34 LG;1166387.9;2000SEP08129 188 forwardTM

35 LG:351357.1:2000SEP08310 396 forwardTM

35 LG;351357.1;2000SEP08467 529 forwardTM N in 35 LG;351357.1:2000SEP08557 619 forwardTM N in 35 LG:351357.1:2000SEP08674 736 forwardTM N in 35 LG:351357.1:2000SEP08761 823 forwardTM N in 35 LG:351357.1:2000SEP08941 1021forwardTM N in 35 LG;351357.1:2000SEP08186 257 forwardTM N in 35 LG;351357.1:2000SEP081119 1199forwardTM N in 36 LG:4b5592.1;2000SEP08163 225 forwardTM N in 36 LG:465592.1;2000SEP08247 309 forwardTM N in 36 LG:465592.1:2000SEP08409 480 forwardTM N in 36 LG;4b5592.1;2000SEP0844 94 forwardTM N in 36 LG;465592.1;2000SEP08221 301 forwardTM N in 36 LG:465592.1;2000SEP0836 104 forwardTM N in 37 LG:OOb848.5:2000SEP08628 b90 forwardTM N out SEQ ID Template ID StartStopFrame Domain Topology NO: Type 38 LG;198450.2;2000SEP08245 331 forward TM N out 38 LG;198450.2:2000SEP08416 469 forward TM N out 38 LG:198450.2:2000SEP08803 889 forward TM N out 38 LG;198450.2;2000SEP08750 818 forward TM N in 39 LG:1008175.1:2000SEP0825 87 forward TM N out 39 LG:1008175.1:2000SEP08115 177 forward TM N out 39 LG;1008175.1;2000SEP08220 297 forward TM N out 39 LG:1008175.1:2000SEP08352 438 forward TM N out 39 LG;1008175.1;2000SEP08478 564 forward TM N out 39 LG:1008175.1:2000SEP08649 705 forward TM N out 39 LG;1008175.1;2000SEP08844 900 forward TM N out 39 LG:1008175.1:2000SEP08407 475 forward TM N in 39 LG:1008175.1;2000SEP08114 200 forward TM N out 39 LG:1008175.1:2000SEP08309 392 forward TM N out 40 LG;437981.1 i 17 79 forward TM N out ;2000SEP08 2 40 LG:437981.11;2000SEP0895 157 forward TM N out 40 LG;437981.11:2000SEP08381 467 forward TM

41 LG;1025549.1;2000SEP08161 241 forward TM N out 41 LG:1025549.1:2000SEP08468 530 forward TM N out 41 LG;1025549.1;2000SEP08540 602 forward TM N out 42 LG;327226.16:2000SEP08178 246 forward TM N in 42 LG;327226.16:2000SEP08256 312 forward TM N in 42 LG:327226.16:2000SEP08325 387 forward TM N in 42 LG:327226.16;2000SEP08403 465 forward TM N in 42 LG;327226.16:2000SEP08224 301 forward TM N in 42 LG:327226.16:2000SEP08353 439 forward TM N in 42 LG:327226.16:2000SEP08252 311 forward TM N in 43 LG:1387394.5:2000SEP08475 5b1 forward TM N in 43 LG:1387394.5:2000SEP08619 705 forward TM N in 43 LG;1387394.5:2000SEP08591 653 forward TM N in 43 LG:1387394.5;2000SEP086b9 731 forward TM N in 44 LG:445188.3;2000SEP08124 177 forward TM N out 44 LG;445188.3;2000SEP08196 258 forward TM N out 44 LG:445188.3:2000SEP08271 333 forward TM N out 44 LG;445188.3:2000SEP08346 408 forward TM N out 44 LG:445188.3;2000SEP08i 187 forward TM N in 44 LG:445188.3:2000SEP08467 526 forward TM N in 44 LG:445188.3;2000SEP08102 188 forward TM N in 44 LG:445188.3:2000SEP08195 281 forward TM N in 44 LG:445188.3;2000SEP08285 350 forward TM N in 44 LG;445188.3:2000SEP08390 476 forward TM N in 45 LG;8988b4.11:2000SEP08i06 192 forward TM N out 45 LG;8988b4.11:2000SEP0850 133 forward TM N out 46 LG:018739.2;2000SEP08124 189 forward TM N in 46 LG:018739.2:2000SEP08454 516 forward TM N in 46 LG:018739.2:2000SEP08553 615 forward TM N in T

46 LG:018739.2;2000SEP08128 208 forward TM

46 LG:018739.2:2000SEP08536 598 forward TM

SEQ ID Template ID StartStop Frame Domain Topology NO; Type 46 LG:018739.2:2000SEP08623 685 forwardTM

46 LG:018739.2:2000SEP08234 305 forwardTM N out 46 LG;018739.2:2000SEP08402 488 forwardTM N out 46 LG:018739.2;2000SEP08555 641 forwardTM N out 47 LG;302915.b:2000SEP08127 207 forwardTM N in 47 LG;302915.b;2000SEP08330 404 forwardTM N out 47 LG:302915.6:2000SEP08501 575 forwardTM N out 47 LG:302915.6:2000SEP08630 716 forwardTM N out 48 LG:404418.3:2000SEP086l 702 forwardTM N out b 1 48 LG:404418.3;2000SEP08479 565 forwardTM N out 48 LG:404418.3:2000SEP08626 682 forwardTM N out 49 LG;374853.2:2000SEP08235 312 forwardTM N out 49 LG:374853.2:2000SEP08913 999 forwardTM N out 49 LG;374853.2;2000SEP0812761362 forwardTM N out 49 LG:374853.2:2000SEP0813841437 forwardTM N out 49 LG:374853.2;2000SEP0816061692 forwardTM N out 49 LG;374853.2:2000SEP08122 208 forwardTM N in 49 LG:374853.2:2000SEP08371 439 forwardTM N in 49 LG;374853.2:2000SEP0811211183 forwardTM N in 49 LG:374853.2;2000SEP0812081270 forwardTM N in 49 LG:374853.2;2000SEP08198 284 forwardTM N in 49 LG:374853.2:2000SEP08381 467 forwardTM N in 49 LG;374853.2;2000SEP0813111397 forward' TM N in 50 LG;228930.1:2000SEP08697 750 forwardTM N out 50 LG;228930.1:2000SEP08111 170 forwardTM N in 50 LG;228930.1;2000SEP08564 650 forwardTM N in 50 LG;228930.1:2000SEP08858 941 forwardTM N in 51 LG:273593.b;2000SEP08343 429 forwardTM

51 LG:273593.b:2000SEP08707 763 forwardTM N out 52 LG;008215.1;2000SEP08181 267 forwardTM N out 52 LG:008215.1:2000SEP08583 663 forwardTM N out 52 LG:008215.1;2000SEP0811231209 forwardTM N out 52 LG:008215.1:2000SEP0814041466 forwardTM N out 53 LG:337160.1:2000SEP08844 930 forwardTM N out 53 LG:337160.1:2000SEP08928 990 forwardTM N out 53 LG:337160.1:2000SEP0810751143 forwardTM N out 53 LG:337160.1:2000SEP0813541437 forwardTM N out 53 LG:337160.1:2000SEP08119 193 forwardTM N in 53 LG:3371b0.1:2000SEP08275 346 forwardTM N in 53 LG;337160.1:2000SEP08491 577 forwardTM N in 53 LG:337160.1:2000SEP0810371120 forwardTM N in 53 LG;337160.1;2000SEP0810141100 forwardTM N out 54 LG:395063.1:2000SEP08331 387 forwardTM N in 54 LG:395063.1:2000SEP08517 603 forwardTM N in 54 LG;395063.1;2000SEP08748 834 forwardTM N in 54 LG:395063.1;2000SEP08850 912 forwardTM N in 54 LG;395063.1;2000SEP08982 1068 forwardTM N in 54 LG:3950b3.1;2000SEP0811111197 forwardTM N in _ - 1 _ _- ._ 78~

SEQ ID Template ID StartStopFrame Domain TypeTopology NO:

54 LG;395063.1:2000SEP081882 1929forwardTM N in 54 LG;395063.1:2000SEP082752 2838forwardTM N in 54 LG:3950b3.1:2000SEP08338 424 forwardTM N out 54 LG;395063.1;2000SEP08464 526 forwardTM N out 54 LG:395063.1;2000SEP08557 619 forwardTM N out 54 LG:395063.1:2000SEP08683 769 forwardTM N out 54 LG:395063.1;2000SEP08860 931 forwardTM N out 54 LG:395063.1;2000SEP081121 1207forwardTM N out 54 LG;395063.1:2000SEP081265 1351forwardTM N out 54 LG:3950b3.1:2000SEP081439 1519forwardTM N out 54 LG:395063.1;2000SEP081571 1657forwardTM N out 54 LG:395063.1:2000SEP081901 1987forwardTM N out 54 LG;395063.1;2000SEP082240 2290forwardTM N out 54 LG:395063.1:2000SEP082405 2491forwardTM N out 54 LG:395063.1;2000SEP081122 1199forwardTM

54 LG:3950b3.1;2000SEP081446 1532forwardTM

54 LG:395063.1;2000SEP081590 1676forwardTM

54 LG:3950b3.1;2000SEP081800 1883forwardTM

54 LG:395063.1;2000SEP082382 2465forwardTM

54 LG:395063.1:2000SEP082796 2846forwardTM

55 LG:979069.4:2000SEP0810 78 forwardTM N in 55 LG:979069.4;2000SEP08196 279 forwardTM N in 55 LG:9790b9.4:2000SEP08889 969 forwardTM N in 55 LG:979069.4;2000SEP081015 1086forwardTM N in 55 LG:979069.4:2000SEP081093 1179forwardTM N in 55 LG;9790b9.4;2000SEP081441 1515forwardTM N in 55 LG;979069.4;2000SEP081783 1860forwardTM N in 55 LG;979069.4:2000SEP08602 664 forwardTM N out 55 LG:979069.4;2000SEP08680 742 forwardTM N out 55 LG;979069.4:2000SEP081424 1492forwardTM N out 55 LG:9790b9.4;2000SEP081757 1843forwardTM N out 55 LG;9790b9.4:2000SEP081871 1957forwardTM N out 55 LG:9790b9.4:2000SEP08339 419 forwardTM N out 55 LG;979069.4;2000SEP08429 491 forwardTM N out 55 LG;9790b9.4;2000SEP08507 569 forwardTM N out 55 LG:979069.4:2000SEP08594 674 forwardTM N out 55 LG:979069.4;2000SEP081422 1472forwardTM N out 55 LG;9790b9.4:2000SEP081863 19i forwardTM N out 56 LG;34bbb3.5;2000SEP08457 513 forwardTM

57 LG;347615.1:2000SEP0852 123 forwardTM

57 LG;347615.1:2000SEP08144 216 forwardTM

58 LG:1397067.1;2000SEP08401 484 forwardTM N in 58 LG:1397067.1:2000SEP08456 524 forwardTM N out 58 LG:1397067.1;2000SEP08660 746 forwardTM N out 59 LG:120675.1;2000SEP08301 372 forwardTM N in 59 LG:120b75.1;2000SEP08559 630 forwardTM N in 1~

59 LG;120b75.1:2000SEP08668 754 forwardTM

59 LG:120b75.1:2000SEP08758 841 forwardTM
_____. 2 _ - _______ _ .

SEQ ID Template iD Start Frame Domain TypeTopology NO: Stop 59 LG;120675.1;2000SEP081316 1372forwardTM

60 LG:420050.18;2000SEP08112 198 forwardTM N out 60 LG;420050.18:2000SEP08205 291 forwardTM ~ N out 60 LG:420050.18:2000SEP08155 241 forwardTM N out 60 LG:420050.18;2000SEP08413 472 forwardTM N out 60 LG:420050.18:2000SEP08210 290 forwardTM N out 6l LG;220495.3;2000SEP08208 294 forwardTM N out 6l LG:220495.3:2000SEP08502 582 forwardTM N out 61 LG;220495.3;2000SEP08631 717 forwardTM N out 61 LG:220495.3:2000SEP08790 846 forwardTM N out 61 LG;220495.3;2000SEP08865 930 forwardTM N out 61 LG:220495.3;2000SEP081432 1518forwardTM N out 6l LG:220495.3:2000SEP081663 1749forwardTM N out 6l LG;220495.3;2000SEP081801 1866forwardTM N'out 61 LG:220495.3:2000SEP081918 1977forwardTM N out 6l LG;220495.3;2000SEP08956 1030forwardTM N out 6l LG;220495.3:2000SEP081439 1501forwardTM N out 61 LG:220495.3:2000SEP081526 1588forwardTM N out 6l LG:220495.3:2000SEP081631 1699forwardTM N out 61 LG:220495.3:2000SEP081760 1843forwardTM N out 6l LG:220495.3:2000SEP081862 1945forwardTM N out 61 LG;220495.3:2000SEP08486 536 forwardTM

6l LG:220495.3:2000SEP08618 677 forwardTM

61 LG;220495.3;2000SEP08702 779 forwardTM

6i LG;220495.3:2000SEP08843 926 forwardTM

61 LG:220495.3;2000SEP08984 1070forwardTM

6l LG;220495.3:2000SEP081449 1499forwardTM

61 LG;220495,3:2000SEP081545 1619forwardTM

61 LG:220495.3;2000SEP081866 1928forwardTM

62 LG;274551.1:2000SEP0881 152 forwardTM N out 62 LG:274551.1:2000SEP08216 269 forwardTM N out 63 LG:429b58.27;2000SEP08373 432 forward~ TM N out 63 LG:429658.27:2000SEP08197 259 forwardTM N out 63 LG;429b58.27;2000SEP08368 430 forwardTM N out 64 LG:246194.18;2000SEP08718 804 forwardTM N out 64 LG;246194.18:2000SEP081816 1890forwardTM N out 64 LG;246194.18;2000SEP08716 763 forwardTM N in ' 2 64 LG:246194.18:2000SEP081793 1879forwardTM N in 64 LG;246194.18:2000SEP08726 782 forwardTM N in 64 LG;24b194.18;2000SEP081830 1883forwardTM N in 65 LG:000874.1:2000SEP08151 237 forwardTM N in 65 LG;000874.1:2000SEP081738 1824forwardTM N in 65 LG:000874.1:2000SEP081849 1935forwardTM N in 65 LG;000874.1:2000SEP08170 256 forwardTM N out 65 LG;000874.1:2000SEP081991 2047forwardTM N out 65 LG;000874.1:2000SEP082078 2155forwardTM N out 65 LG;000874.1:2000SEP08168 233 forwardTM N in 65 LG:000874.1:2000SEP08627 713 forwardTM N in _ _ _ 3 ____ g0 SEQ ID Template ID Start Frame Domain Topology NO; Stop Type 65 LG:000874.1;2000SEP081383 1469forwardTM N in 65 LG:000874.1:2000SEP082109 2162forwardTM N in 66 LG:239967.7:2000SEP08136 189 forwardTM N out 67 LG;238388.1:2000SEP08544 618 forwardTM N out 67 LG:238388.1:2000SEP081477 1536forwardTM N out 67 LG;238388.1:2000SEP081975 2028forwardTM N out 67 LG:238388.1:2000SEP082029 2100forwardTM N out 67 LG:238388.1;2000SEP082275 2346forwardTM N out 67 LG;238388.1:2000SEP082377 2463forwardTM N out 67 LG;238388.1:2000SEP082734 2790forwardTM N out 67 LG:238388.1:2000SEP082803 2889forwardTM N out 67 LG:238388.1;2000SEP082998 3084forwardTM N out 67 LG:238388.1:2000SEP083118 3204forwardTM N out 67 LG:238388.1:2000SEP083265 3351forwardTM N out 67 LG:238388.1:2000SEP083415 3489forwardTM N out 67 LG:238388.1:2000SEP083550 3612forwardTM N out 67 LG:238388.1;2000SEP083664 3726forwardTM N out 67 LG:238388.1;2000SEP081337 1399forwardTM N out 67 LG:238388.1:2000SEP081727 1804forwardTM N out 67 LG:238388.1;2000SEP081883 1969forwardTM N out 67 LG:238388.1:2000SEP082003 2065forwardTM N out 67 LG;238388.1:2000SEP082084 2146forwardTM N out 67 LG:238388.1;2000SEP082459 2545forwardTM N out 67 LG:238388.1:2000SEP082600 2686forwardTM N out 67 LG;238388.1:2000SEP082714 2785forwardTM N out 67 LG:238388.1:2000SEP082837 2923forwardTM N out 67 LG;238388.1:2000SEP082945 3031forwardTM N out 67 LG:238388.1;2000SEP083176 3256forwardTM N out 67 LG:238388.1:2000SEP083308 3394forwardTM N out 67 LG:238388.1:2000SEP083545 3622forwardTM N out 67 LG:238388.1:2000SEP081473 1553forwardTM

b7 LG:238388.1:2000SEP081755 1805forwardTM

67 LG:238388.1;2000SEP081860 1928forwardTM

b7 LG;238388.1;2000SEP082232 2318forwardTM

67 LG:238388.1;2000SEP082634 2720forwardTM

67 LG:238388.1;2000SEP082766 2834forwardTM

67 LG:238388.1:2000SEP082877 2951forwardTM

67 LG:238388.1;2000SEP083021 3092forwardTM

b7 LG:238388.1:2000SEP083369 3452forwardTM

67 LG:238388.1:2000SEP083636 3719forwardTM

68 LG:233b74.4:2000SEP083175 3261forwardTM N in 68 LG:233674.4:2000SEP083526 3612forwardTM N in 68 LG:233674.4:2000SEP081826 1885forwardTM N out 68 LG:233674.4:2000SEP083285 3365forwardTM N out 68 LG:233674.4;2000SEP083474 3560forwardTM N out 69 LG:411327.2:2000SEP08226 312 forwardTM N out 69 LG:411327.2:2000SEP081327 1407forwardTM N out 69 LG:411327.2:2000SEP08239 322 forwardTM N out SEQ ID Template ID Start Frame Domain TypeTopology NO. Stop 69 ~ LG;411327.2;2000SEP08794 865forward TM N out 69 LG:411327.2:2000SEP08588 650forward TM N in 69 LG:411327.2:2000SEP08666 728forward TM N in 69 LG;411327.2;2000SEP08744 806forward TM N in 69 LG;411327.2:2000SEP08828 914forward TM N in 69 LG;411327.2:2000SEP081557 1643forward TM N in 69 LG:411327.2:2000SEP081749 1829forward TM N in 69 ' LG:411327.2;2000SEP081842 1925forward TM N in 70 LG:1327310.1:2000SEP08193 258forward TM N in 71 LG:242019.13;2000SEP08367 453forward TM N out 71 LG:242019.13:2000SEP08402 452forward TM N out 72 LG:012432.12:2000SEP08319 405forward TM N in 72 LG:O T 2432. T 526 612forward TM N in 2:2000SEP08 1 72 LG:012432.12:2000SEP08290 376forward TM N in 72 LG;Oi2432.T2:2000SEP08506 565forward TM N in 72 LG:012432.12;2000SEP08677 757forward TM N in 72 LG;012432.12:2000SEP08642 695forward TM N out 73 LG:257088.9;2000SEP081231 1302forward TM N out T

73 LG;257088.9;2000SEP081339 1425forward TM N out 73 LG:257088.9:2000SEP08152 229forward TM

73 LG:257088.9:2000SEP08656 739forward TM

73 LG:257088.9:2000SEP0872 143forward TM

73 LG;257088.9;2000SEP08630 692forward TM

73 LG:257088.9:2000SEP08939 1010forward TM

74 LG;997505.5;2000SEP081036 1089forward TM N out 74 LG:997505.5:2000SEP081092 1142forward TM N in 74 LG:997505.5;2000SEP081224 1271forward TM N in 75 LG:481436.2;2000SEP0810 60 forward TM N out 75 LG;481436.2;2000SEP08256 324forward TM N out 75 LG:481436.2:2000SEP08430 516forward TM N out 75 LG;481436.2;2000SEP08562 648forward TM N out 75 LG:48143b.2:2000SEP08775 834forward TM N out 75 LG;481436.2:2000SEP081060 1122forward TM N out 75 LG:481436.2:2000SEP08T 1209forward TM N out 75 LG;481436.2:2000SEP081414 1500forward TM N out 75 LG:481436.2:2000SEP081522 1608forward TM N out 75 LG;481436.2;2000SEP08230 316forward TM N in 75 LG:481436.2;2000SEP08359 436forward TM N in 75 LG:481436.2:2000SEP08536 607forward TM N in 75 LG;481436.2;2000SEP08635 697forward TM N in 75 LG:481436.2:2000SEP08710 772forward TM N in 75 LG;481436.2;2000SEP08785 847forward TM N in 75 LG:481436.2:2000SEP081385 1471forward TM N in 75 LG:481436.2;2000SEP081502 1570forward TM N in 75 LG;481436.2:2000SEP08276 353forward TM

75 LG:481436.2;2000SEP08522 608forward TM

75 LG;481436.2:2000SEP08840 926forward TM

75 LG:481436.2;2000SEP081383 1469forward TM
- ____ 3 __._ _ g2 SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 75 LG;481436.2:2000SEP081500 1586forwardTM

76 LG:247776.i4:2000SEP08932 985 forwardTM N out 77 LG:008606.14:2000SEP08414 500 forwardTM N in 77 LG:008606.14:2000SEP08540 587 forwardTM N in 77 LG:008606.14:2000SEP081146 1199forwardTM N in 78 LG;985092.3;2000SEP0824 110 forwardTM N out 79 LG;236b49.7:2000SEP08370 456 forwardTM N in 79 LG:236649.7;2000SEP08377 463 forwardTM N out 79 LG;236649.7:2000SEP08366 440 forwardTM N in 80 LG:245014.2:2000SEP081345 1407forwardTM N in 80 LG:245014.2;2000SEP081426 1488forwardTM N in 80 LG:245014.2:2000SEP08464 541 forwardTM N in 80 LG:245014.2;2000SEP08599 655 forwardTM N in 80 LG;245014.2:2000SEP08731 817 forwardTM N in 80 LG:245014.2:2000SEP081325 1408forwardTM N in 80 LG:245014.2;2000SEP08252 338 forwardTM N out 80 LG;245014.2:2000SEP081335 1421forwardTM N out 81 LG:170754.4:2000SEP08244 330 forwardTM N out 81 LG:170754.4;2000SEP0871 157 forwardTM N in 81 LG:170754.4:2000SEP08206' 292 forwardTM N in 81 LG;170754.4:2000SEP08585 635 forwardTM N in 82 LG:988028.1:2000SEP08268 354 forwardTM N out 83 LG;427997.b:2000SEP08148 222 forwardTM ' N out 83 LG;427997.b:'2000SEP08739 822 forwardTM N out 83 LG:427997.b:2000SEP08859 939 forwardTM N aut 83 LG;427997.b:2000SEP08i 1395forwardTM N out 83 LG:427997.b:2000SEP081609 1695forwardTM N out 83 LG:427997.b:2000SEP081726 1812forwardTM N out 83 LG;427997.b;2000SEP082107 2187forwardTM N out 83 LG:427997.b:2000SEP08134 220 forwardTM N in 83 LG;427997.6:2000SEP08752 829 forwardTM N in 83 LG;427997.6:2000SEP081229 1309forwardTM N in 83 LG;427997.b:2000SEP081487 1540forwardTM N in 83 LG:427997.b;2000SEP081619 1687forwardTM N in 83 LG:427997.b:2000SEP081715 1789forwardTM N in 83 LG:427997.b:2000SEP08150 236 forwardTM N out 83 LG:427997.b:2000SEP08681 743 forwardTM N out 83 LG:427997.b:2000SEP08759 821 forwardTM N out 83 LG;427997.b:2000SEP081074 1142forwardTM N out 83 LG:427997.b;2000SEP081 1256forwardTM N out i 3 83 LG:427997.b:2000SEP081449 1520forwardTM N out 83 LG:427997.b:2000SEP081740 1826forwardTM N out 84 LG:464206.1;2000SEP084 81 forwardTM N out 84 LG:464206.1:2000SEP0811 82 forwardTM N out 84 LG;464206.1:2000SEP08105 170 forwardTM N out 85 LG:1400108.1:2000SEP08283 351 forwardTM N out 85 LG:1400108.1;2000SEP08373 447 forwardTM N out 85 LG:1400108.1:2000SEP08598 684 forwardTM N out SEQ ID Template ID StartStopFrame Domain TypeTopology NO;

85 LG:1400108.1:2000SEP08724 786 forwardTM N out 85 LG:1400108.1:2000SEP08802 864 forwardTM N out 85 LG:1400108.1:2000SEP08871 948 forwardTM N out 85 LG;1400108.1:2000SEP0892 175 forwardTM N out 85 LG:1400108.1:2000SEP08293 355 forwardTM N out 85 LG:1400108.1:2000SEP08368 430 forwardTM N out 85 LG:1400108.1:2000SEP08587 649 forwardTM N out 85 LG:1400108.1:2000SEP08662 724 forwardTM N out 85 LG;1400108.1:2000SEP08785 862 forwardTM N out 85 LG:1400108.1;2000SEP08884 970 forwardTM N out 85 LG:1400108, i 300 37 forwardTM N out :2000SEP08 i 3 85 LG:1400108.1;2000SEP08393 446 forwardTM N out 85 LG:1400108.1:2000SEP08651 737 forwardTM N out 85 LG:1400108.1;2000SEP08765 827 forwardTM N out 85 LG:1400108.1:2000SEP08852 914 forwardTM N out 86 LG:254531.1;2000SEP0831 111 forwardTM N in 86 LG;254531.1:2000SEP08277 327 forwardTM N in 86 LG:254531.1:2000SEP0853 133 forwardTM N out 86 LG:254531.1:2000SEP08548 634 forwardTM N out 86 LG;254531.1;2000SEP0860 110 forwardTM N in 86 LG;25453 i , i 231 305 forwardTM N in :2000SEP08 3 86 LG:254531.1;2000SEP08495 581 forwardTM N in 86 LG:254531.1;2000SEP08687 761 forwardTM N in 87 LG;1101317.1:2000SEP08607 678 forwardTM N out 87 LG:1101317.1:2000SEP081186 1236forwardTM N out 87 LG;1101317.1:2000SEP082482 2568forwardTM N out 87 LG;1101317.1:2000SEP082825 2899forwardTM N out 87 LG:1101317.1;2000SEP081023 1091forwardTM N out 87 LG;1101317.1;2000SEP081194 1271forwardTM N out 88 LG:1074728.6:2000SEP081 250 forwardTM N in b4 2 88 LG: T 074728.6;2000SEP08437 523 forwardTM N in 89 LG:1081684.1:2000SEP08124 210 forwardTM

89 LG:1081684.1:2000SEP08256 330 forwardTM

89 LG;1081684.1;2000SEP08361 423 forwardTM

89 LG:1081 b84.1:2000SEP08460 522 forwardTM

89 LG:1081684.1:20005EP08179 265 forwardTM N in 89 LG:1081684.1;2000SEP08626 673 forwardTM N in 89 LG;1081684.1;2000SEP08147 233 forwardTM N out 89 LG;1081684.1:2000SEP08273 341 forwardTM N out 89 LG:1081684.1:2000SEP08438 509 forwardTM N out 90 LG:1076520.1:2000SEP0870 132 forwardTM N out 90 LG;107b520.1:2000SEP08151 213 forwardTM N out 90 LG:1076520.1;2000SEP08232 294 forwardTM N out 90 LG:1076520.1:2000SEP08310 378 forwardTM N out 90 LG: i 076520.1:2000SEP08550 636 forwardTM N out 90 LG:1076520.1;2000SEP08760 828 forwardTM N out 91 LG:1079477.1:2000SEP0810 75 forwardTM N out 91 LG:1079477.1:2000SEP08115 189 forwardTM N out _ _ 1 _ g4 SEQ ID Template !D Start Frame Domain TypeTopology NO; Stop 91 LG:1079477.1:2000SEP0826 88 forwardTM N out 91 LG:T079477.1:2000SEP08122 184 forwardTM N out 91 LG:1079477.1:2000SEP0827 92 forwardTM N in 92 LG:107b2b9.1:2000SEP08299 358 forwardTM N out 92 LG:1076269.1:2000SEP08443 520 forwardTM N out 93 LG; T 087195.1;2000SEP08974 1045forwardTM N in 93 LG:1087195.1:2000SEP08945 1031forwardTM N out 93 LG:1087195.1:2000SEP08T 1271forwardTM N out 94 LG:002588.7:2000SEP0828 114 forwardTM N out 94 LG:002588.7:2000SEP08130 186 forwardTM N out 94 LG:002588.7:2000SEP08349 432 forwardTM N out 94 LG:002588.7:2000SEP08436 522 forwardTM N out 94 LG:002588.7:2000SEP08613 690 forwardTM N out 94 LG:002588.7:2000SEP0838 100 forwardTM N out 94 LG:002588.7:2000SEP08T T forwardTM N out 94 LG;002588.7:2000SEP08374 436 forwardTM N out 94 LG;002588.7;2000SEP08458 520 forwardTM N out 94 LG:002588.7;2000SEP08542 604 forwardTM N out 94 LG;002588.7:2000SEP08623 709 forwardTM N out 94 LG:002588.7:2000SEP0830 11 forwardTM N out b 3 94 LG;002588.7;2000SEP08150 224 forwardTM N out 94 LG:002588.7;2000SEP08423 494 forwardTM N out 94 LG:002588.7;2000SEP08546 632 forwardTM N out 94 LG;002588.7;2000SEP08759 842 forwardTM N out 95 LG:1079470.6:2000SEP0825 111 forwardTM N in 95 LG;1079470.b;2000SEP08208 294 forwardTM N in . 1 95 LG;1079470.b:2000SEP08448 531 forwardTM N in 95 LG;1079470.6;2000SEP081021 1107forwardTM N in 95 LG;1079470.6;2000SEP0856 142 forwardTM N out 95 LG:1079470.6:2000SEP08209 295 forwardTM N out 95 LG:1079470.6;2000SEP08389 442 forwardTM N out 95 LG;1079470.b:2000SEP086T 691 forwardTM N out 95 LG;1079470.b:2000SEP08863 946 forwardTM N out 95 LG:1079470.6:2000SEP081016 1078forwardTM N out 95 LG;1079470.6;2000SEP081097 1159forwardTM N out 95 LG:1079470.b:2000SEP08378 440 forwardTM N out 95 LG;1079470.b;2000SEP08474 536 forwardTM N out 95 LG;1079470.6:2000SEP08744 824 forwardTM N out 96 LG;345705.3;2000SEP08187 270 forwardTM N in 97 LG:1083654.1;2000SEP081066 1152forwardTM N out 97 LG;1083b54.1;2000SEP082836 2898forwardTM N out 97 LG:1083b54.1:2000SEP082917 2979forwardTM N out 97 LG:1083b54.1:2000SEP083337 3423forwardTM N out 97 LG:1083b54.1:2000SEP08197 283 forwardTM N out 97 LG;1083b54.1:2000SEP08650 736 forwardTM N out 97 LG:1083b54.1:2000SEP081049 1135forwardTM N out 97 LG:1083b54.1:2000SEP082681 2767forwardTM N out 97 LG; T 083b54.1:2000SEP082975 3061forwardTM N out SJ

SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 97 LG:1083654.1:2000SEP0831613247forward TM N out 97 LG:1083654.1:2000SEP08765 827 forward TM N in 97 LG:1083654.1:2000SEP0810471133forward TM N in 97 LG:1083654.1:2000SEP0825922666forward TM N in 97 LG:1083654.1:2000SEP0827332819forward TM N in 97 LG:1083b54,1:2000SEP0829253011forward TM N in 97 LG:1083b54.1:2000SEP0831293215forward TM N in 98 LG:198782,3:2000SEP08814 900 forward TM

98 LG:198782.3:2000SEP0813391392forward TM

98 LG:198782,3:2000SEP0816781764forward TM

98 LG:198782.3:2000SEP08233 283 forward TM N in 98 LG:198782.3:2000SEP08830 892 forward TM N in , 2 98 LG:198782,3:2000SEP0816551741forward TM N in 98 LG:198782.3:2000SEP0820752137forward TM N in 98 LG:198782,3:2000SEP0826392695forward TM N in 98 LG:198782,3:2000SEP08792 878 forward TM N in 98 LG:198782.3:2000SEP0820402111forward TM N in 98 LG:198782,3:2000SEP0825772651forward TM N in 99 LG:981076.2:2000SEP0819 81 forward TM N out 99 LG:981076.2:2000SEP08409 495 forward TM N out 99 LG:981076,2:2000SEP08538 603 forward TM N out 99 LG:981076.2:2000SEP08437 523 forward TM N in 99 LG:981076.2:2000SEP08387 449 forward TM N in 100 LG:212023.3:2000SEP08265 342 forward TM N out 100 LG:212023,3:2000SEP0811291215forward TM N out 100 LG:212023.3:2000SEP08497 583 forward TM N in 100 LG:212023,3:2000SEP0811811231forward TM N in 100 LG:212023,3:2000SEP08501 587 forward TM N in 100 LG:212023.3:2000SEP08627 698 forward TM N in 100 LG:212023.3:2000SEP08732 794 forward TM N in 100 LG:212023,3:2000SEP08822 884 forward TM N in 100 LG:212023.3:2000SEP0810111064forward TM N in 101 LG:977929.3:2000SEP08115 177 forward TM N out 101 LG:977929.3:2000SEP08196 258 forward TM N out 102 LG:201936.b:2000SEP08445 519 forward TM N out 102 LG:201936,6:2000SEP0892 178 forward TM N out 102 LG:201936.6:2000SEP08449 511 forward TM N out 102 LG:201936.6:2000SEP08521 583 forward TM N out 102 LG:207 93b.6:2000SEP08641 709 forward TM N out 102 LG:201936,b:2000SEP08719 802 forward TM N out 102 LG:20193b,b:2000SEP08279 326 forward TM N out 103 LG:205642.1:2000SEP08172 237 forward TM N in 103 LG:205642.1:2000SEP08674 751 forward TM N out 103 LG:205642.1:2000SEP08752 832 forward TM N out 103 LG:205642.1:2000SEP08935 1021forward TM N out 103 LG:205642.1:2000SEP08117 197 forward TM N in 103 LG:205642.1:2000SEP08717 797 forward TM N in 104 LG:339653.b:2000SEP0828 105 forward TM N in SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 105 LG:978587.4;2000SEP08394 474 forwardTM N out 105 LG:978587.4;2000SEP0811 64 forwardTM N out 105 LG:978587.4:2000SEP08506 592 forwardTM N out 105 LG;978587.4:2000SEP0812 68 forwardTM N out 106 LG;21 b848, i 309 395 forwardTM N in 7:2000SEP08 3 107 LG;219502.1:2000SEP08109 195 forwardTM N out i 07 LG:219502, i ;2000SEP082 289 forwardTM
. i 2 107 LG;219502,1:2000SEP08740 802 forwardTM

107 LG;2i9502.1;2000SEP08228 293 forwardTM N out 107 LG:219502,1:2000SEP08378 431 forwardTM N out 108 LI:334211.1;2000SEP0879 141 forwardTM N out 108 LI:334211.1:2000SEP0880 142 forwardTM N out 108 LI:334211.1;2000SEP08686 739 forwardTM N out 108 LI;334211,1:2000SEP0890 146 forwardTM N out 108 LI:334211.1;2000SEP0810831133 forwardTM N out 109 LI;231024,2;2000SEP08304 357 forwardTM

109 LI;231024.2;2000SEP0813601446 forwardTM

109 LI:231024.2;2000SEP085b3 628 forwardTM N in 109 LI;231024,2:2000SEP08851 937 forwardTM N in 109 LI;231024.2;2000SEP0812471333 forwardTM N in 109 LI;231024.2;2000SEP0813701420 forwardTM N in 109 LI:231024,2:2000SEP0814661519 forwardTM N in 109 LI;231024,2:2000SEP0815 101 forwardTM N in 109 LI;231024.2;2000SEP0812811349 forwardTM N in 109 LI;231024.2;2000SEP0813531424 forwardTM N in 109 LI;231024.2;2000SEP0814671538 forwardTM N in 109 LI;231024,2:2000SEP0815781625 forwardTM N in 110 LI:228425.5;2000SEP08178 255 forwardTM N out 110 L1:228425,5;2000SEP08385 435 forwardTM N out 110 LI;228425.5;2000SEP08778 864 forwardTM N out 110 LI;228425,5;2000SEP08401 487 forwardTM N in 110 LI:228425.5;2000SEP08644 715 forwardTM N in 110 LI:228425.5;2000SEP08770 850 forwardTM N in i 10 Li;228425,5:2000SEP08147 233 forwardTM N in 110 LI:228425,5;2000SEP08267 338 forwardTM N in 110 LI:228425.5;2000SEP08381 467 forwardTM N in 110 LI:228425,5;2000SEP08624 680 forwardTM N in 111 LI;034493,1:2000SEP08319 381 forwardTM N in 111 LI;034493.1:2000SEP08421 483 forwardTM N in 111 LI:034493.1:2000SEP08323 391 forwardTM N out 111 LI:034493,1;2000SEP08410 493 forwardTM N out 11 i LI:034493.1:2000SEP08617 703 forwardTM N out i 11 LI:034493, i ;2000SEP08285 3b8 forwardTM N in 111 LI:034493.1;2000SEP08408 470 forwardTM N in 11 i LI;034493.1:2000SEP08492 554 forwardTM N in 111 LI:034493.1;2000SEP08576 638 forwardTM N in i 11 LI:034493,1:2000SEP08759 82i forwardTM N in 111 LI:034493.1;2000SEP08858 920 forwardTM N in _ ~ _ 3 _ _ _-g7 SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 112 LI:336218.1:2000SEP0829 85 forwardTM N in 112 LI:336218.1:2000SEP08143 229 forwardTM N in 112 LI:33b218,1:2000SEP08278 349 forwardTM N in 113 LI:235891.3:2000SEP08380 436 forward, TM N out 114 LI:344094.1:2000SEP0837 123 forwardTM N in 114 LI:344094.1:2000SEP08223 306 forwardTM N in 114 LI:344094,1:2000SEP08493 579 forwardTM N in 114 LI:344094.1:2000SEP08631 717 forwardTM N in 114 LI:344094,1:2000SEP0844 1 forwardTM
Ob 2 114 LI:344094,1:2000SEP08122 184 forwardTM

114 LI:344094.1;2000SEP08218 280 forwardTM

114 LI:344094.1:2000SEP08521 607 forwardTM

114 LI:344094,1:2000SEP0824 110 forwardTM N in 114 LI:344094.1:2000SEP08210 287 forwardTM N in 114 LI:344094.1:2000SEP08534 620 forwardTM N in 115 LI:399945.2:2000SEP08546 605 forwardTM

116 LI:051849,1:2000SEP08175 261 forwardTM N out 117 LI:238379,3:2000SEP08450 524 forwardTM N in 118 LI:352190.8:2000SEP08194 241 forwardTM N out 119 LI:432120.1:2000SEP08681 767 forwardTM

120 LI:055461.1:2000SEP08349 435 forwardTM N in 120 LI:055461,1:2000SEP0813451407 forwardTM N in 120 LI:055461.1:2000SEP08146 208 forwardTM N out 120 LI:055461.1:2000SEP08242 304 forwardTM N out 120 LI:055461,1:2000SEP08662 724 forwardTM N out 120 LI:055461.1:2000SEP0813791450 forwardTM N out 121 LI:197433.5:2000SEP0819 81 forwardTM N out 121 LI:197433.5:2000SEP08100 162 forwardTM N out 121 LI:197433,5:2000SEP08175 261 forwardTM N out 121 LI:197433.5:2000SEP08355 417 forwardTM N out 121 LI:197433,5:2000SEP08442 504 forwardTM ~ N
1 out 121 LI:197433.5:2000SEP08529 591 forwardTM N out 7 22 LI:170b04.1:2000SEP08439 516 forwardTM N out 122 LI:170b04,1:2000SEP08429 515 forwardTM N out 123 LI:205057.3:2000SEP0810 72 forwardTM N in 123 LI:205057.3:2000SEP08139 210 forwardTM N in 123 LI:205057,3:2000SEP08437 499 forwardTM N in 123 LI:205057.3:2000SEP08512 574 forwardTM N in 123 LI:205057.3:2000SEP0812 98 forwardTM N out 123 LI:205057.3:2000SEP08150 236 forwardTM N out 124 LI:233795.1:2000SEP0892 1 forwardTM N in b6 2 124 LI:233795.1:2000SEP08108 161 forwardTM N out 125 LI:311197.1:2000SEP08241 318 forwardTM

125 LI:311197.1:2000SEP08604 690 forwardTM

i 25 LI:311 i 97, i 530 592 forwardTM N out :2000SEP08 2 125 LI:311197.1:2000SEP08614 676 forwardTM N out 125 LI:311197.1:2000SEP08621 701 forwardTM N in 126 LI:441364.1:2000SEP08321 377 forwardTM N in SEQ ID Template ID StartStopFrame Domain TypeTopology NO:

i 27 LI:2i 03b7.b:2000SEP08330 4i forward TM' N in 128 LI:238194.5:2000SEP08457 543 forward TM N in 129 LI;039258.5:2000SEP08396 482 forward TM N in 130 LI:1071842.1:2000SEP08439 486 forward TM N out 130 LI:1071842.1;2000SEP08504 575 forward TM N out 131 LI:481356.3:2000SEP08580 663 forward TM N out 132 Ll: ) 03474.1:2000SEP0810 90 forward TM N out 132 LI:103474.1:2000SEP08100 1 forward TM N out b8 1 132 LI:103474.1:2000SEP08412 462 forward TM N out 132 LI;103474.1:2000SEP0811 76 forward TM N out 132 LI:103474.1:2000SEP0815 101 forward TM N out 132 LI:103474.1:2000SEP08117 185 forward TM N out 132 LI;103474.1:2000SEP082b7 353 forward TM ~ N
3 out 133 LI:1073020.10:2000SEP086i3 699 forward TM N out i 133 LI;1073020.10:2000SEP0811 97 forward TM N out 133 LI:1073020.10:2000SEP08818 880 forward TM N out 133 LI;1073020.10:2000SEP0812591330forward TM N out 133 LI;1073020.10;2000SEP08270 353 forward TM N in 133 LI:1073020.10:2000SEP0810081094forward TM N in 134 LI:000874.1;2000SEP08151 237 forward TM N in 134 LI;000874.1:2000SEP0817381824forward TM N in 134 LI:000874.1:2000SEP0818491935forward TM N in 134 LI:000874.1:2000SEP0821042157forward TM N in 134 LI:000874.1:2000SEP08170 256 forward TM N in 134 LI:000874.1;2000SEP08168 233 forward TM N in 134 LI;000874.1:2000SEP08627 713 forward TM N in 134 Li;000874.1:2000SEP0813831469forward TM N in 134 LI:000874.1;2000SEP0820372093forward TM N in 134 LI:000874.1:2000SEP0821242201forward TM N in 135 LI:037298.2;2000SEP08373 441 forward TM N in 135 LI:037298.2;2000SEP084b0 540 forward TM N in 135 LI;037298.2:2000SEP08b25 675 forward TM N in 135 LI:037298.2;2000SEP08715 777 forward TM N in 135 LI:037298.2:2000SEP08793 855 forward TM N in 135 LI;037298.2:2000SEP08889 951 forward TM N in 135 LI:037298.2:2000SEP08997 1059forward TM N in 135 LI;037298.2:2000SEP0811171203forward TM N in 135 LI:037298.2;2000SEP0812731344forward TM N in 135 LI:037298.2:2000SEP0815071578forward TM N in 135 LI:037298.2:2000SEP0817831869forward TM N in 135 LI:037298.2:2000SEP0810671141forward TM N in 135 LI:037298.2:2000SEP0814751561forward TM N in 135 LI:037298.2:2000SEP0825042590forward TM N in 135 . LI:037298.2:2000SEP08471 551 forward TM

135 LI:037298.2;2000SEP0810621133forward TM

135 LI:037298.2:2000SEP0815181583forward TM

135 LI:037298.2:2000SEP0817791862forward TM

135 LI:037298.2;2000SEP0824842537forward TM
_ 3 _ SEQ ID Template ID Start Frame DomainType Topology NO; Stop 136 LI:422901.1:2000SEP0867 132 forward TM N in 136 LI:422901.1:2000SEP08256 336 forward TM N in 136 LI:422901.1:2000SEP08550 612 forward TM N in 136 LI;422901.1;2000SEP08625 687 forward TM N in 136 LI:422901.1;2000SEP08700 762 forward TM N in 136 LI;422901.1;2000SEP08413 466 forward TM N out 136 LI;422901.1:2000SEP08617 700 forward TM N out 136 LI;422901.1:2000SEP0811721249forward TM N out 137 LI:345815.1:2000SEP08580 666 forward TM N in 137 LI;345815.1;2000SEP0812161278forward TM N in 137 LI:345815.1:2000SEP0815041590forward TM N in 137 LI;345815.1:2000SEP0817891875forward TM N in 137 LI;345815.1:2000SEP08221 289 forward TM N in 137 LI:345815.1:2000SEP08320 367 forward TM N in 137 LI:345815.1:2000SEP08413 499 forward TM N in 137 LI;345815.1:2000SEP08665 727 forward TM N in 137 LI:345815.1:2000SEP08740 802 forward TM N in 137 LI;345815.1;2000SEP08878 949 forward TM N in 137 LI;~345815.1;2000SEP0810581138forward TM N in 137 LI:345815.1:2000SEP0817931879forward TM N in 137 LI:345815.1;2000SEP08372 428 forward TM N in 137 LI;345815.1:2000SEP08585 671 forward TM N in 137 LI:345815.1:2000SEP08813 899 forward TM N in 137 LI:345815.1;2000SEP0811401199forward TM N in 137 LI:345815.1:2000SEP0812901376forward TM N in 137 LI;345815.1:2000SEP0814761562forward TM N in 137 LI;345815.1:2000SEP0816681754forward TM N in 137 LI;345815.1:2000SEP0817761853forward TM N in 138 LI;1072014.2;2000SEP08674 760 forward TM N in 139 L1:333138.3:2000SEP0819 96 forward TM N out 139 LI;333138.3:2000SEP08116 181 forward TM N out 139 LI:333138.3:2000SEP08272 331 forward TM N out 140 LI:414253.1:2000SEP08115 201 forward TM N out 140 LI:414253.1:2000SEP0822722358forward TM N out 140 LI:414253.1:2000SEP08107 193 forward TM N in 140 LI;414253.1:2000SEP0817271777forward TM N in 140 LI:414253.1;2000SEP0822852365forward TM N in 140 LI:414253.1:2000SEP0824112464forward TM N in 140 LI;414253.1:2000SEP08108 182 forward TM N out 140 LI:414253.1:2000SEP0823462429forward TM N out 141 LI;406389.1;2000SEP08106 180 forward TM

141 LI:406389.1:2000SEP08490 576 forward TM

141 LI;406389.1:2000SEP08595 681 forward TM

141 LI:406389.1;2000SEP08709 780 forward TM

142 LI:108b171.1;2000SEP08226 312 forward TM

142 LI:1086171.1;2000SEP08218 304 forward TM N out 142 LI:1086171.1:2000SEP08240 311 forward TM N out 142 LI:108b171.1:2000SEP08420 _479forward TM N out SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 143 LI;198782.4;2000SEP08235 285 forwardTM N in 143 LI;198782.4:2000SEP08838 924 forwardTM N in 143 LI:198782.4:2000SEP0816901776 forwardTM N in 143 LI:198782.4:2000SEP0820892175 forwardTM N in 143 LI:198782.4:2000SEP0826772739 forwardTM N in 143 LI:198782.4:2000SEP0829052988 forwardTM N in 143 LI;198782.4:2000SEP0831033186 forwardTM N in 143 LI:198782.4:2000SEP0832623348 forwardTM N in 143 L1:198782.4:2000SEP0836853747 forwardTM N in 143 LI:198782.4:2000SEP0837693831 forwardTM N in 143 LI;198782.4;2000SEP0838533915 forwardTM N in 143 LI:198782.4;2000SEP0842104275 forwardTM N in 143 LI:198782.4:2000SEP0844834569 forwardTM N in 143 LI:198782.4;2000SEP0847564842 forwardTM N in 143 LI;198782.4;2000SEP0848914977 forwardTM N in 143 LI;198782.4;2000SEP08809 895 forwardTM N out 143 LI;198782.4;2000SEP08i T forwardTM N out 143 LI:198782.4:2000SEP0825672653 forward~ TM N out 143 LI:198782.4:2000SEP0826602725 forwardTM N out 143 LI:198782.4:2000SEP0827382797 forwardTM N out 143 LI:198782.4;2000SEP0829182974 forwardTM N out 143 LI:198782.4:2000SEP0837403802 forwardTM N out 143 LI:198782.4;2000SEP0838303892 forwardTM N out 143 LI:198782.4:2000SEP0842774363 forwardTM N out 2' 143 LI:198782.4:2000SEP0844754561 forwardTM N out 143 LI;198782.4;2000SEP0847304816 forwardTM' N out 143 LI:198782.4:2000SEP0848534939 forwardTM N out 143 LI:198782.4:2000SEP08816 899 forwardTM N in 143 LI;198782.4;2000SEP0812691355 forwardTM N in T 43 LI;198782.4;2000SEP0823282408 forwardTM N in 143 LI:198782.4:2000SEP0826762756 forwardTM N in 143 LI:198782.4:2000SEP0837383800 forwardTM N in 143 LI:198782.4:2000SEP0838223884 forwardTM N in 143 LI;198782.4:2000SEP0841734238 forwardTM N in 143 LI:198782.4:2000SEP0842694337 forwardTM N in 143 LI:198782.4:2000SEP0848544940 forwardTM N in 143 LI:198782.4;2000SEP0849565036 forwardTM N in 144 LI:2030279.1:2000SEP08193 279 forwardTM N out 144 LI:2030279.1:2000SEP08496 558 forwardTM N out 144 LI:2030279. T 577 639 forwardTM N out ;2000SEP08 1 144 LI;2030279.1:2000SEP08649 723 forwardTM N out 144 LI:2030279. T 29 79 forwardTM N in :2000SEP08 2 144 LI:2030279.1;2000SEP0898 157 forwardTM N in 144 LI:2030279.1:2000SEP08179 265 forwardTM N in T 44 LI:2030279. T 374 436 forwardTM N in ;2000SEP08 2 144 LI;2030279.1:2000SEP08449 511 forwardTM N in 144 LI:2030279.1;2000SEP08662 739 forwardTM N in 144 LI;2030279.1:2000SEP081118_1204 forwardTM N in SEQ ID Template ID StartStop Frame Domain TypeTopology NO:

144 LI:2030279.1:2000SEP08177 263 forwardTM N in 144 LI:2030279.1:2000SEP08288 374 forwardTM N in 144 LI:2030279.1:2000SEP08456 518 forwardTM N in 144 LI;2030279.1;2000SEP08534 596 forwardTM N in 144 LI:2030279.1:2000SEP086i5 701 forwardTM N in 144 LI:2030279.1:2000SEP0811401190 forwardTM N in 144 LI:2030279.1:2000SEP0813561424 forwardTM N in 145 LI:1018424.3:2000SEP08107 175 forwardTM N out 146 LI:130969.1:2000SEP08973 1044 forwardTM N out 146 LI:130969.1;2000SEP0826 91 forwardTM N out 146 LI:1309b9.1:2000SEP08458 544 forwardTM N out 146 LI;130969.1:2000SEP08108 167 forwardTM N out 147 LI:286246.2:2000SEP08373 447 forwardTM N in 147 LI:286246.2:2000SEP0817 1185 forwardTM N in 147 LI:286246.2;2000SEP0810971156 forwardTM N out 147 LI:28b246.2:2000SEP0815141576 forwardTM N out 147 LI:28b246.2;2000SEP0824262512 forwardTM N out 147 LI:286246.2:2000SEP08345 431 forwardTM N out 147 LI:28b246.2;2000SEP08528 590 forwardTM N out 147 LI:28b246.2:2000SEP0811641217 forwardTM N out 148 LI:001527.1:2000SEP08658 744 forwardTM N out 148 LI:001527.1;2000SEP08916 993 forwardTM N out 148 . LI:001527.1;2000SEP08335 421 forwardTM N out 148 LI:001527.7:2000SEP08566 652 forwardTM N out 148 LI:001527.1;2000SEP08686 766 ~ forwardTM N out 148 LI:001527.1:2000SEP08860 946 forwardTM N out 148 LI:001527.1:2000SEP08968 1054 forwardTM N out 148 LI;001527.1;2000SEP08405 491 forwardTM N out 148 LI:001527.1:2000SEP08705 791 forwardTM N out 148 LI:001527.1;2000SEP08936 986 forwardTM N out 148 LI;001527.1:2000SEP08984 1070 forwardTM N out 149 LI:395063.1:2000SEP08331 387 forwardTM N in 149 LI;395063.1:2000SEP08517 603 forwardTM N in 149 LI:395063.1:2000SEP08748 834 forwardTM N in 149 LI:395063.1;2000SEP08850 912 forwardTM N in 149 LI:395063.1;2000SEP08982 1068 forwardTM N in 149 LI:3950b3.1;2000SEP0811111197 forwardTM N in 149 LI;395063.1:2000SEP0815281614 forwardTM N in 149 LI:395063.1;2000SEP081,6151677 forwardTM N in 149 LI:395063.1:2000SEP0827762862 forwardTM N in 149 LI;395063.1:2000SEP08338 424 forwardTM N out 149 LI:395063.1:2000SEP08464 526 forwardTM N out 149 LI:395063.1:2000SEP08557 619 forwardTM N out 149 LI:3950b3.1:2000SEP08683 769 forwardTM N out 149 LI:395063.1:2000SEP08860 931 forwardTM N out 149 LI:395063.1:2000SEP0811211207 forwardTM N out 149 LI:395063.1;2000SEP0812591345 forwardTM N out 149 LI:395063.1:2000SEP0818261888 forwardTM N out SEQ ID Template iD Start Frame Domain Topology NO: Stop Type 149 LI:3950b3.1:2000SEP0822642314forward TM N out 149 LI:3950b3.1:2000SEP0824292515forward TM N out 149 LI:3950b3.1:2000SEP0811221199forward TM N in 149 LI:3950b3,1:2000SEP0816411727forward TM N in 149 LI:3950b3,1:2000SEP0824272513forward TM N in 149 LI:395063.1:2000SEP0828172867forward TM N in 150 LI:lOb4460.1:2000SEP08376 444 forward TM N out 150 LI:1064460.1:2000SEP08487 549 forward TM N out 150 LI:1064460.1:2000SEP08574 636 forward TM N out 150 LI:1064460.1:2000SEP08116 190 forward TM N out 150 LI:1064460.1:2000SEP08362 424 forward TM N out 150 LI:1064460.1:2000SEP08437 499 forward TM N out 150 LI: l Ob4460,1:2000SEP0854 116 forward TM N in 150 LI:1064460.1:20DOSEP08132 194 forward TM N in 150 LI:1064460.1:2000SEP08210 272 forward TM N in 150 LI:1064460.1:2000SEP08297 365 forward TM N in 150 LI:1064460.1:2000SEP08441 527 forward TM N in 150 LI:1064460.1:2000SEP08618 704 forward TM N in 150 LI:I 064460.1:2000SEP08750 836 forward TM N in 151 LI:344690,2:2000SEP08277 348 forward TM N out 151 LI:344b90,2:2000SEP08131 199 forward TM N in 151 LI:344690.2:2000SEP08284 337 forward TM N in 151 LI:344b90,2:2000SEP08129 215 forward TM N in 151 LI:344b90.2:2000SEP08465 524 forward TM N in 152 LI:061585,4:2000SEP08349 417 forward TM N out 152 LI:061585.4:2000SEP08628 714 forward TM N out 152 LI:061585,4:2000SEP08404 490 forward TM N in 152 LI:Ob1585,4:2000SEP08623 709 forward TM N in 152 LI:061585.4:2000SEP08953 1033forward TM N in 152 LI:061585.4:2000SEP08609 668 forward TM N in 152 LI:061585,4:2000SEP08882 962 forward TM N in 153 LI:378428.1:2000SEP0819572043forward TM N in 153 LI:378428,1:2000SEP0822332310forward TM N in 153 LI:378428.1:2000SEP08704 790 forward TM N in 153 LI:378428.1:2000SEP0822672353forward TM N in 153 LI:378428.1:2000SEP0813591445forward TM N out 153 LI:378428.1:2000SEP0816501715forward TM N out 153 LI:378428,1:2000SEP0819652027forward TM N out 154 LI:474108,2:2000SEP08982 1068forward TM N out 154 LI:474108,2:2000SEP0811321215forward TM N out 154 LI:474108.2:2000SEP0829022964forward TM N out 154 LI:474108,2:2000SEP0829923054forward TM N out 154 LI:474108.2:2000SEP0832593321forward TM N out 154 LI:474108,2:2000SEP0833943480forward TM N out 154 LI:474108.2;2000SEP0835803654forward TM N out 154 LI:474108,2:2000SEP0838593918forward TM N out 154 LI:474108.2:2000SEP0839464032foi~nrardTM N out 154 LI:474108.2:2000SEP0844504536forward TM N out SEQ ID Template ID StartStop Frame Domain TypeTopology NO;

154 LI:474108.2:2000SEP0846214707 forwardTM N out 154 LI:474108.2:2000SEP0847684854 forwardTM N out 154 LI;474108.2:2000SEP0811421219 forwardTM N out 154 LI:474108.2:2000SEP0812801360 forwardTM N out 154 LI:474108.2:2000SEP0815081570 forwardTM N out 154 LI:474108.2;2000SEP0815801666 forwardTM N out 154 LI;474108.2:2000SEP0818411909 forwardTM N out 154 LI;474108.2:2000SEP0820452101 forwardTM N out 154 LI:474108.2:2000SEP0824232506 forwardTM N out 154 LI;474108.2:2000SEP0826482734 forwardTM N out 154 LI:474108.2;2000SEP0829062992 forwardTM N out 154 LI:474108.2:2000SEP0833743460 forwardTM N out 154 LI:474108.2;2000SEP0835033565 forwardTM N out 154 LI:474108.2:2000SEP0835783640 forwardTM N out 154 LI;474108.2;2000SEP0838033889 forwardTM N out 154 LI;474108.2:2000SEP0843194372 forwardTM N out 154 LI:474108.2:2000SEP0845684654 forwardTM N out 154 LI;474108.2;2000SEP0851175179 forwardTM N out 154 LI:474108.2:2000SEP0830 116 forward~ TM N out 154 LI:474108.2:2000SEP0814191478 forwardTM N out 154 LI:474108.2;2000SEP0816021664 forwardTM N out 154 LI;474108.2:2000SEP0816801742 forwardTM N out 154 LI:474108.2;2000SEP0820882174 forwardTM N out 154 LI:474108.2:2000SEP0829012987 forwardTM N out 154 LI:474108.2;2000SEP0830933179 forwardTM N out i54 LI:474108.2:2000SEP0834i 3497 forwardTM N out 154 LI;474108.2:2000SEP0835613647 forwardTM N out 154 LI:474108.2;2000SEP0842694325 forwardTM N out 154 LI;474108.2:2000SEP0845844637 forwardTM N out 154 LI:474108.2:2000SEP0847584844 forwardTM N out 154 LI;474108.2:2000SEP0852055276 forwardTM N out 155 LI:230711.2:2000SEP0872T 795 forwardTM N in 155 LI:230711.2;2000SEP08880 963 forwardTM N in 155 LI;230711.2:2000SEP0816961767 forwardTM N in 155 LI;230711.2:2000SEP08863 949 forwardTM

155 LI:230711.2:2000SEP0810851168 forwardTM

155 LI;230711.2:2000SEP08147 233 forwardTM N out 155 LI:230711.2:2000SEP08720 803 forwardTM N out 155 LI:230711.2:2000SEP0810801142 forwardTM N out 155 LI:230711.2:2000SEP0811551217 forwardTM N out 155 LI;230711.2;2000SEP0816201706 forwardTM N out 155 LI:230711.2:2000SEP0818151874 forwardTM N out 156 LI;008942.1:2000SEP08253 324 forwardTM N out 156 LI:008942.1;2000SEP0813091371 forwardTM N out 156 LI:008942.1:2000SEP0813931455 forwardTM N out 156 LI;008942.1;2000SEP08359 445 forwardTM N out 156 LI;008942.1:2000SEP08797 871 forwardTM N out 156 LI:008942.1:2000SEP0813551441 forwardTM N out _ 2 _ .___ SEQ ID Template ID StartStop Frame Domain TypeTopology NO:

156 LI:008942,1:2000SEP08696 776 forwardTM N in 156 LI:008942,1:2000SEP0813711442 forwardTM N in 156 LI:008942,1:2000SEP0819141997 forwardTM N in 157 LI:732479.1:2000SEP08649 723 forwardTM N out 157 LI:732479.1:2000SEP08721 807 forwardTM N out 157 LI:732479.1:2000SEP08829 909 forwardTM N out 157 LI:732479,1:2000SEP081084i forwardTM N out 157 LI:732479.1:2000SEP0812611323 forwardTM N out 157 LI:732479.1:2000SEP0814231509 forwardTM N out 157 LI:732479.1:2000SEP08869 928 forwardTM N in 157 LI:732479.1:2000SEP0812201306 forwardTM N in 157 LI:732479.1:2000SEP08534 605 forwardTM N in 157 LI:732479.1:2000SEP08846 902 forwardTM N in 157 LI:732479.1:2000SEP0815061568 forwardTM N in 158 LI:1190250,1:2000SEP08570 629 forwardTM N out 159 LI:1013717.1:2000SEP0825 87 forwardTM N out 159 LI:1013717,1:2000SEP08115 177 forwardTM N out i 59 LI: i 0 i 3717.1:2000SEP08220 297 forwardTM N out 159 LI:1013717,1:2000SEP08352 438 forwardTM N out 159 LI:1013717,1:2000SEP08511 582 forwardTM N out 159 LI:1013717,1:2000SEP08407 478 forwardTM N in 159 LI:1013717,1:2000SEP08617 673 forwardTM N in 159 LI:1013717,1:2000SEP08812 868 forwardTM N in 159 LI:1013717.1:2000SEP08114 200 forwardTM N out 159 LI:1013717,1:2000SEP08309 392 forwardTM N out 1 b0 LI:2049125.2:2000SEP08129 215 forwardTM

161 LI:1092360,1:2000SEP0843 114 forwardTM N out 161 LI:1092360,1:2000SEP08400 474 forwardTM N out lbl LI:1092360.1:2000SEP0865 118 forwardTM N out 161 LI:1092360.1:2000SEP08444 530 forwardTM N out 162 LI:791524,1:2000SEP0810 75 forwardTM N out 162 LI:791524.1:2000SEP08115 189 forwardTM N out 162 LI:791524.1:2000SEP0826 88 forwardTM N out 162 LI:79i 524,1:2000SEP08122 184 forwardTM N out 162 LI:791524,1:2000SEP0827 92 forwardTM N in 163 LI:1084555.3:2000SEP0837 123 forwardTM N in 1 b3 LI:1084555.3:2000SEP08176 256 forwardTM N in 163 LI:1084555,3:2000SEP08332 415 forwardTM N in 163 LI:1084555,3:2000SEP08' 158 forwardTM N out 1 b4 LI:8,15418,2:2000SEP0819852071 forwardTM N out 1 b4 LI:815418.2:2000SEP0819532039 forwardTM N in 165 LI:41 6766,1:2000SEP08259 318 forwardTM N in 1 b5 LI:416766.1:2000SEP08343 405 forwardTM N in 165 LI:416766.1:2000SEP08418 480 forwardTM N in 165 LI:416766.1:2000SEP0813121398 forwardTM N in 165 LI:416766.1:2000SEP0829563030 forwardTM N in 165 LI:416766,1:2000SEP0830973183 forwardTM N in 165 LI:416766.1:2000SEP0832773333 forwardTM N in ___- 1 9j SEQ ID Template ID StartStop Frame Domain Topology NO: Type 165 LI:416766,1;2000SEP08626 694 forwardTM N in 165 LI:416766.1:2000SEP08989 1051 forwardTM N in 165 LI:41b76b.1;2000SEP0812861372 forwardTM N in 1 b5 LI:4167bb.1;2000SEP0829723034 forwardTM N in 165 LI;416766,1:2000SEP0830623124 forwardTM N in 1 b5 LI:416766.1:2000SEP08375 455 forwardTM N in 165 LI;416766.1:2000SEP0812901376 forwardTM N in 1 b5 LI;41 6766,1:2000SEP0829403026 forwardTM N in 165 LI:416766.1;2000SEP0832343305 forwardTM N in 166 LI;1171008,2:2000SEP0861 117 forwardTM N in 1 b7 LI:11 b9888.3;2000SEP0879 165 forwardTM

1 b7 LI:1169888.3:2000SEP08286 372 forwardTM

i67 LI:1169888,3;2000SEP08505 591 forwardTM
i 1 b7 LI:1169888.3:2000SEP08781 864 forwardTM

1 b7 LI:1169888.3:2000SEP08913 999 forwardTM
i 167 LI:11b9888.3;2000SEP0898 178 forwardTM N in 1 b7 LI:1169888.3;2000SEP08290 352 forwardTM N in 1b7 LI:11b9888,3:2000SEP08374 436 forwardTM N in 167 LI;1169888.3:2000SEP08518 604 forwardTM N in 167 LI:11 b9888.3:2000SEP08704 754 forwardTM N in 167 LI;1169888.3:2000SEP08758 832 forwardTM N in 167 LI;1169888.3:2000SEP08866 952 forwardTM N in 1 b7 LI:1169888,3;2000SEP0893 155 forwardTM N out 1 b7 LI:11 b9888,3:2000SEP08186 248 forwardTM N out 1 b7 LI;1169888.3:2000SEP08402 473 forwardTM N out 1 b7 LI:1169888.3;2000SEP08519 581 forwardTM N out 1 b7 LI;1169888.3:2000SEP08591 653 forwardTM N out 1 b7 LI:1169888.3;2000SEP08813 893 forwardTM N out 1 b7 LI;11 b9888.3:2000SEP08963 1013 forwardTM N out 1 b8 LI;412592,1:2000SEP08145 225 forwardTM

1 b8 LI;412592,1;2000SEP0811381224 forwardTM

T 69 LI:349808.1:2000SEP0822 108 forwardTM N out 1 b9 LI:349808,1;2000SEP0825482613 forwardTM N out 169 LI:349808,1:2000SEP0826742730 forwardTM N out T

1 b9 LI;349808,1;2000SEP0821382224 forwardTM N in 169 LI:349808,1:2000SEP0819021961 forwardTM N in 1 b9 LI:349808,1:2000SEP0827122765 forwardTM N in 170 LI:3491 b4,2:2000SEP08139 21 forwardTM N out b 1 170 LI:349164.2:2000SEP082i4 300 forwardTM N out 170 LI:3491 b4.2;2000SEP08325 411 forwardTM N out 170 LI:349164.2:2000SEP08442 489 forwardTM N out 170 LI:349164,2;2000SEP08125 211 forwardTM N out 170 LI:349164.2:2000SEP08344 430 forwardTM N out 170 LI:349164,2:2000SEP08515 601 forwardTM N out 2 ~

170 LI;349164.2:2000SEP08998 1057 forwardTM N out 170 LI:3491 b4.2;2000SEP0812 68 forwardTM N out 170 LI:349164.2:2000SEP0896 182 forwardTM N out 170 LI:349164.2:2000SEP08315 401 forwardTM N out SEQ ID Template ID Start Frame Domain TypeTopology NO: Stop 170 LI:349164.2:2000SEP08543 611forward TM N out 171 LI;20541 3.1;2000SEP082194 2280forward TM N in 171 LI:205413.1:2000SEP082171 2233forward TM N in 171 LI;205413.1:2000SEP082600 2680forward TM N in 172 LI;2051508.2;2000SEP08268 354forward TM N out 173 LI;34b242.2:2000SEP08983 1042forward TM N out 173 LI;346242.2:2000SEP08882 9b8forward TM N in 173 LI;34b242.2;2000SEP081488 1574forward TM N in 174 LI;2052717.1:2000SEP081396 1470forward TM N in 174 LI:2052717.1;2000SEP081513 1575forward TM N in 174 LI:2052717.1:2000SEP081609 1671forward TM N in 174 LI;2052717.1:2000SEP081463 1534forward TM N out 174 LI:2052717.1:2000SEP081532 1615forward TM N out 174 LI;2052717.1:2000SEP081635 1700forward TM N out 175 LI;4066b8.2:2000SEP081474 1545forward TM N in 1 75 Li:406668.2:2000SEP081888 1 forward TM N in 175 LI:406668.2;2000SEP082191 2277forward TM N in 175 LI;406668.2:2000SEP081871 1957forward TM N in 175 LI:40bb68.2;2000SEP082228 2290forward TM N in 175 LI;406668.2:2000SEP082109 2192forward TM N in 1 76 LI:1178352.1;2000SEP08568 654forward TM N in 176 LI:1178352.1;2000SEP081279 1365forward TM N in 176 LI:1178352.1:2000SEP081654'1716forward TM N in 176 LI;1178352.1:2000SEP081741 1803forward TM N in 176 LI:1178352.1;2000SEP082077 2148forward TM N in 17b LI;1178352.1:2000SEP0868 154forward TM N out 176 LI;1178352.1;2000SEP08359 442forward TM N out 176 LI:1178352.1:2000SEP081643 1729forward TM N out 176 LI:I 178352.1;2000SEP0821 107forward TM N out 176 LI:1178352.1:2000SEP08534 596forward TM N out 176 LI:I 178352.1:2000SEP08627 689forward TM N out 1 76 LI:1178352.1;2000SEP08705 782forward TM N out 176 LI:1178352.1;2000SEP08852 905forward TM N out 177 LI;814014.7:2000SEP08607 b69forward TM N out 177 LI:814014.7:2000SEP08599 685forward TM N out 177 L1:814014.7:2000SEP081 1193forward TM N out 178 LI:I 170624.1:2000SEP08299 358forward TM N out 178 LI:1 1 70624.1;2000SEP08443 520forward TM N out 179 LI;1183171.1:2000SEP08166 237forward TM

179 LI:1183171.1:2000SEP0829 115forward TM N out 179 L1:1183171.1;2000SEP081 218forward TM N out b8 3 180 LI:1093491.1;2000SEP08154 207forward TM N in 180 LI:1093491.1;2000SEP08562 648forward TM N in 180 LI; 1 093491.1:2000SEP08649 702forward TM N in 180 LI:1093491.1;2000SEP0873b 807forward TM N in 180 LI;1093491.1:2000SEP08575 655forward TM N in 180 LI;1093491.1;2000SEP08695 748forward TM N in 180 LI:1093491.1:2000SEP08618 _689forward TM N in ~ 3 SEQ ID Template ID Start Frame Domain Topology NO. Stop Type 181 LI;04b515.5;2000SEP084b0 546 forward TM N in 181 LI:046515.5:2000SEP0817 82 forward TM N out 181 LI;046515.5:2000SEP08314 388 forward TM N out 181 LI:04b5T5.5:2000SEP08515 571 forward TM N out 181 LI:04b515.5:2000SEP08141 209 forward TM N out 181 LI;046515.5;2000SEP08351 419 forward TM N out 181 LI:04b515.5:2000SEP08447 533 forward TM N out T 82 LI:400T 71.2:2000SEP08511 597 forward TM N out T

182 LI:400171.2:2000SEP08567 653 forward TM N out 183 LI:330919.6:2000SEP0870 150 forward TM N out 183 LI:330919.b;2000SEP08151 219 forward TM N out 183 LI;330919.b:2000SEP08256 309 forward TM N out 183 LI;330919.b;2000SEP08313 399 forward TM N out 183 LI;330919.b:2000SEP0856 130 forward TM N out 183 LI:330919.b:2000SEP08128 208 forward TM N out 183 LI:330919.6;2000SEP08311 358 forward TM N out 183 LI;330919.b;2000SEP0863 113 forward TM N in 183 LI:330919.b:2000SEP08135 194 forward TM N in 183 LI:330919.b:2000SEP08297 353 forward TM N in 184 LI:219502.1;2000SEP08316 402 forward TM N out 184 LI;219502.1:2000SEP08487 540 forward TM N out 184 LI:219502.1:2000SEP08233 319 forward TM N in 184 LI:219502.1:2000SEP08324 410 forward TM

184 LI:219502.1;2000SEP08861 923 forward TM

SEQ ID Template ID Component Start Stop NO: ID

1 LG:983076,3:2000SEP087763237)1 782 1359 1 LG:983076.3:2000SEP087763237H1 527 1177 1 LG:983076,3:2000SEP086816661 J 303 880 1 LG:983076.3:2000SEP086816661 H 1 424 2 LG:1382987,7:2000SEP087221401H1 71 612 2 LG:1382987.7:2000SEP085539617H2 697 902 2 LG:1382987.7:2000SEP086911289) 188 790 2 LG:1382987,7:2000SEP087039246H1 1 489 3 LG:235557.15:2000SEP087013257H1 1 267 3 LG:235557,15:2000SEP083190036R6 1 267 3 LG:235557.15:2000SEP083190036H1 1 164 3 LG:235557.15:2000SEP083974159H1 140 380 3 LG:235557,15:2000SEP087714837) 197 291 3 LG:235557.15:2000SEP087714836H1 197 261 4 LG:O 7 8494.1:2000SEP08g5878576 358 801 4 LG:018494.1:2000SEP082875821 H1 665 800 4 LG:018494,1:2000SEP082875821 Fb 664 800 4 LG:018494.1:2000SEP08144378076 315 761 4 LG:018494.1:2000SEP08433194779 106 698 4 LG:O i 8494. i 433192079 150 671 :2000SEP08 4 LG:018494.1:2000SEP087267178H2 103 605 4 LG:018494.1:2000SEP08g6397885 133 294 4 LG:018494.1:2000SEP084676232H1 1 264 4 LG:018494.1:2000SEP082868107H1 665 805 LG:980494.1:2000SEP08g5541169 1219 1543 5 LG:980494.1:2000SEP08g2958236 1226 1414 5 LG:980494,1:2000SEP081 6l 875676 1247 1841 5 LG:980494,1:2000SEP087618177) 1629 21 O1 5 LG:980494,1:2000SEP081943565H1 1698 1877 5 LG:980494.1:2000SEP08g3331178 1075 1412 5 LG:980494,1:2000SEP086713531 H 11 b9 1537 5 LG:980494.1:2000SEP087683622H1 949 1454 5 LG:980494,1:2000SEP087682580H1 949 1455 5 LG:980494,1:2000SEP081784942H 957 1189 5 LG:980494.1:2000SEP08g6451273 1050 1412 5 LG:980494,1:2000SEP087684929H 949 1476 5 LG:980494.1:2000SEP08g3092119 930 1415 5 LG:980494,1:2000SEP08g2726574 947 11 b7 5 LG:980494,1:2000SEP084291592H 790 942 5 LG:980494,1:2000SEP084145168H 829 1119 5 LG:980494.1:2000SEP084125405H1 872 1148 5 LG:980494.1:2000SEP082078150H 742 1002 5 LG:980494,1:2000SEP08g 1785426 748 1188 5 LG:980494,1:2000SEP082430567H1 755 1007 5 LG:980494.1:2000SEP084576269F6 770 1374 5 LG:980494.1:2000SEP084291692H 788 881 5 LG:980494,1:2000SEP082214403H1 627 874 5 LG:980494.1:2000SEP084713559H1 499 750 ~_._ SEQ ID Template ID Component Start Stop NO: ID

LG:980494.1;2000SEP082214403F6 627 1059 5 LG:980494.1:2000SEP082212765H 1 627 881 5 LG:980494.1:2000SEP085515783H1 703 959 5 LG:980494.1;2000SEP084290144H1 738 996 5 LG:980494.1;2000SEP086725205H1 1 614 5 LG:980494.1;2000SEP08596464379 122 634 5 LG:980494.1:2000SEP08g2783200 342 848 5 LG;980494.1:2000SEP081618504H1 447 671 5 LG;980494.1;2000SEP081618756F6 447 854 5 LG:980494.1;2000SEP081618749H 1 447 649 5 LG:980494.1;2000SEP081686804H 1 450 670 5 LG:980494.1;2000SEP081785019H1 450 698 5 LG;980494.1:2000SEP08g2835145 474 737 6 LG:984457.2:2000SEP086784190H1 435 952 b LG:984457.2:2000SEP086715771 H 454 976 b LG:984457.2:2000SEP083368817F6 534 1083 6 LG:984457.2;2000SEP083368817H1 534 807 b LG:984457.2;2000SEP087353082H1 560 1130 b LG:984457.2;2000SEP085754149H1 750 1273 b LG;984457.2:2000SEP08249056976 1 546 6 LG:984457.2;2000SEP08379946776 25 358 6 LG:984457.2;2000SEP083413777H1 321 565 6 LG;984457.2;2000SEP087674559J1 396 946 7 LG:406758.1:2000SEP08g711128 930 1174 7 LG:406758.1:2000SEP082270260H1 803 1065 7 LG:406758.1;2000SEP083203437F6 518 1024 7 LG:406758.1;2000SEP085768790H 1 439 1013 7 LG;40b758.1;2000SEP082573541 H1 555 809 7 LG:406758.1;2000SEP083203437H1 520 770 7 LG:40b758.1;2000SEP086777565H1 1 634 7 LG;406758.1:2000SEP087690831 J 229 618 7 LG:406758.1:2000SEP085047721 R6 37 350 7 LG:406758.1;2000SEP087338496H1 867 1358 7 LG:406758.1;2000SEP083249541 H 1040 1354 7 LG;406758.1;2000SEP085690615H1 1042 1310 7 LG;40b758.1:2000SEP08g696761 930 1277 7 LG:40b758.1;2000SEP08g734852 930 1228 7 LG;406758.1;2000SEP08409935579 1518 1663 7 LG;40b758.1;2000SEP08g718527 1446 1656 7 LG;406758.1;2000SEP08g734770 1392 1647 7 LG:406758.1:2000SEP08g696594 1443 1647 7 LG:40b758.1;2000SEP08320343776 1124 1645 7 LG:40b758.1;2000SEP08424320876 1340 1645 7 LG:406758.1;2000SEP08g4451158 1390 1645 7 LG:406758.1:2000SEP08g4564394 1365 1645 7 LG;40b758.1:2000SEP08g3679317 1324 1645 7 LG;40b758.1;2000SEP08g2838157 1304 1645 7 LG:40b758.1:2000SEP08133437876 1315 1645 SEQ ID Template ID Component Start Stop NO: ID

7 LG;406758.1:2000SEP087747262H1 1271 1645 7 LG;406758.1;2000SEP083343574Th 1206 1645 7 LG:406758.1:2000SEP081334378Fb 1156 1517 7 LG;406758.1:2000SEP081334378H 1156 1410 8 LG:902957.17:2000SEP085742915H1 1 294 9 LG:333179.1;2000SEP08g703579 183 475 9 LG;333179.1:2000SEP08g713006 183 4b4 9 LG;333179.1;2000SEP086026950H1 1 275 9 LG:333179.1;2000SEP085800088H 1 625 9 LG;333179.1:2000SEP081746609H1 5 2b1 9 LG;333179.1:2000SEP081746609Fb 5 555 9 LG:333179.1:2000SEP082006872H 6 148 9 LG:333179.1;2000SEP082473167F6 b 4b9 9 LG:333179.1:2000SEP082473167H 6 239 9 LG;333179.1:2000SEP08033784H1 27 298 9 LG:333179.1:2000SEP085282372H2 27 207 9 LG:333179.1:2000SEP084997b89H 33 287 9 LG:333179.1:2000SEP08g2034987 39 323 9 LG:333179.1;2000SEP08030695H 1 39 241 9 LG:333179.1:2000SEP08g2154206 61 161 9 LG;333179.1:2000SEP084995956H1 79 340 9 LG;333179.1:2000SEP086246345H1 1 526 9 LG:333179.1;2000SEP08g1924106 1 369 9 LG;333179.1;2000SEP08171289H 1 1 230 9 LG:333179.1:2000SEP08007672H 1 195 4b3 9 LG:333179.1;2000SEP084400180H 203 308 9 LG;333179.1:2000SEP084198119H1 221 473 9 LG:333179.1;2000SEP08gb697567 328 786 9 LG;333179.1:2000SEP08g4735257 332 784 9 LG;333179.1;2000SEP08g6661884 338 782 9 LG;333179.1;2000SEP08g4739770 351 786 9 LG;333179.1;2000SEP0883400569 360 .792 9 LG:333179.1;2000SEP081975405H1 370 556 9 LG;333179.1:2000SEP0883144451 371 782 9 LG:333179.1;2000SEP0884125056 375 791 9 LG:333179.1:2000SEP0885804179 381 786 9 LG;333179.1;2000SEP0884741035 384 785 9 LG:333179.1:2000SEP088280b047 387 787 9 LG;333179.1:2000SEP08864627b9 387 785 9 LG;333179.1:2000SEP0885765850 414 790 9 LG:333179.1:2000SEP0882821034 422 787 9 LG:333179.1;2000SEP0885631640 453 783 9 LG;333179.1;2000SEP0883737203 454 608 9 LG:333179.1:2000SEP0885393676 478 785 9 LG;333179.1:2000SEP0883118453 485 785 9 LG:333179.1;2000SEP0883162475 487 785 9 LG:333179.1:2000SEP08gb5b7793 503 787 9 LG;333179.1;2000SEP082010119H1 534 642 SEQ ID Template ID Component Start Stop NO: ID

9 LG;333179.1;2000SEP082473167Th 613 739 9 LG:333179.1:2000SEP08g703479 648 933 9 LG:333179.1:2000SEP08g723722 674 921 LG:406568.1;2000SEP082324266H1 1336 1578 10 LG;406568.1;2000SEP083011865F6 1339 1760 10 LG:406568.1:2000SEP083576519H1 1338 1494 10 LG:406568. i ;2000SEP085176829H 1347 1599 l 10 LG:4065b8.1;2000SEP083873606H1 1350 1660 10 LG:406568.1;2000SEP084852614H 1362 1586 10 LG:406568.1;2000SEP087753572) 1376 1936 10 LG:406568. i :2000SEP083958442H 1376 1473 i 10 LG:406568.1:2000SEP083016113F6 1375 1646 10 LG;406568.1;2000SEP08058529H1 1375 1521 10 LG:406568.1;2000SEP085276870H1 1375 1534 10 LG:406568.1:2000SEP083011865H 1375 1458 10 LG:406568.1:2000SEP083578346H1 1381 1633 10 LG:406568.1:2000SEP083016113H 1382 1668 10 LG;406568.1;2000SEP086337413H 1389 1506 10 LG:406568.1:2000SEP086338013H1 1389 1880 10 LG;406568.1:2000SEP086335720H 1389 l 882 10 LG:406568.1:2000SEP083688195H1 1397 1694 10 LG;406568.1;2000SEP084151882H 1400 1640 10 LG:4065b8.1:2000SEP083874704Hi 1438 1713 10 LG;406568.1;2000SEP085169119H 1475 1609 10 LG:406568.1:2000SEP085278359H1 1474 1704 10 LG:40b568.1:2000SEP083685458H1 1485 1782 10 LG;40b568.1:2000SEP086332978H i 486 198 1 i 10 LG:406568.1:2000SEP085531678H 1494 1623 10 LG;40b5b8.1:2000SEP08g5395484 1512 1853 10 LG:406568.1;2000SEP083693626H 1511 1803 10 LG;4065b8.1:2000SEP084152946H1 1519 1791 10 LG:40b568.1;2000SEP083890704H 1547 1841 10 LG:40b568.1:2000SEP083875504H1 1548 1850 10 LG:406568.1:2000SEP084466716H1 1581 1838 10 LG:40b568.1:2000SEP08g395449 1590 1922 10 LG;40b5b8.1;2000SEP085i67337H1 1591 1799 10 LG:406568.1:2000SEP08g6836605 1592 1891 10 LG;4065b8.1:2000SEP08920392H 1 1610 1922 10 LG:406568.1;2(~OOSEP083011865Th 1617 ~ 1971 10 LG:406568. i :2000SEP08301 b i 13Th1673 2154 10 LG;406568.1:2000SEP085277911 H1 1696 1934 10 LG:406568.1:2000SEP083874759H 1 295 10 LG;406568.1;2000SEP083685395H1 3 270 10 LG:406568.1:2000SEP08g311 6688 4 442 10 LG:406568.1;2000SEP083692640H1 4 269 10 LG:40b568.1:2000SEP083692640F6 4 341 10 LG:406568.1:2000SEP083445829H2 6 263 10 LG:406568.1:2000SEP08306745H 1 13 385 SEQ ID Template ID Component Start Stop NO: ID

LG:40b568,1:2000SEP08945423H 1 11 292 10 LG:4065b8.1:2000SEP087752844H1 21 658 10 LG:406568.1:2000SEP087369625H 40 556 10 LG:40b568,1:2000SEP0898824881 178 382 10 LG:406568.1:2000SEP08988248H1 178 290 10 LG:40b5b8.1:2000SEP084454887H1 249 518 10 LG:406568.1:2000SEP087753572H 272 808 10 LG:406568,1:2000SEP083877090H1 349 618 10 LG:40b568.1:2000SEP086901148H 367 824 10 LG:4065b8.1:2000SEP083028782F6 504 840 10 LG:406568.1:2000SEP083028782Hi 504 806 10 LG:406568.1:2000SEP087752949)1 532 1080 10 LG:4065b8,1:2000SEP087416011 Tl 548 952 10 LG:406568.1:2000SEP087754049H1 569 1211 10 LG:40b568.1:2000SEP081005592H1 598 888 10 LG:406568.1:2000SEP087754049) 639 1265 10 LG:406568.1:2000SEP087752949H1 683 1175 10 LG:40b5b8, l :2000SEP087753382) 726 1 i 10 LG:406568.1:2000SEP087752844)1 800 1346 10 LG:40b568.1:2000SEP084646393H1 800 1060 10 LG:40b568,1:2000SEP085278286H1 911 1124 10 LG:40b568.1:2000SEP082521969F6 949 1353 10 LG:40b568.1:2000SEP08983403H 1 1062 1334 10 LG:406568.1:2000SEP0898340386 1063 1314 10 LG:406568.1:2000SEP08188949H 1 1105 1305 10 LG:406568.1:2000SEP08983403T6 1122 1346 10 LG:406568.1:2000SEP08988925H 1 1125 1348 10 LG:40b568.1:2000SEP082521969H1 1128 1353 10 LG:406568. i :2000SEP082639257H 1176 1338 10 LG:406568.1:2000SEP08983273H1 1240 1543 10 LG:406568.1:2000SEP083692640T6 1246 1831 10 LG:406568.1:2000SEP084013213H1 1307 1597 10 LG:406568.1:2000SEP084010336H 1327 1610 10 LG:4065b8.1:2000SEP083877453H1 1330 1613 10 LG:406568,1:2000SEP083013979H 1876 21 b8 10 LG:406568.1:2000SEP08921802H1 1887 2213 10 LG:40b568.1:2000SEP08920885H1 1887 2203 10 LG:406568.1:2000SEP085278931 H1 1995 2213 10 LG:4065b8.1:2000SEP08058768H1 1997 2200 10 LG:40b568.1:2000SEP083045908H1 2012 2280 10 LG:406568,1:2000SEP08g2787073 2047 2206 10 LG:4065b8.1:2000SEP08979691 H1 1835 2119 10 LG:406568.1:2000SEP08g434193 1851 2025 7 0 LG:4065b8.1:2000SEP085803204H 1825 2023 10 LG:406568.1:2000SEP082636153H1 1699 1928 10 LG:406568.1:2000SEP081567405H 1705 1888 10 LG:406568.1:2000SEP0846251386 1705 2043 10 LG:406568,1:2000SEP08462513H1 1705 1930 .

~0J

SE6~ Template ID Component Start Stop ID NO: ID

LG:4065b8.1:2000SEP083877471 H1 1720 1989 10 LG;406568.1:2000SEP085277625H1 1722 1972 10 LG:40b568.1:2000SEP083016674H1 1738 2023 10 LG:406568.1:2000SEP083045188H1 1738 2024 10 LG:406568.1:2000SEP085299216H 1 1760 2000 10 LG;4065b8.1:2000SEP0897760571 1763 2178 10 LG:40b568.1:2000SEP08977605R1 1763 2142 10 LG:406568.1:2000SEP08977605H1 1763 2074 10 LG;4065b8.1:2000SEP083487465H1 1764 2053 10 LG:40b568.1:2000SEP08302878276 1766 2193 10 LG:4065b8.1:2000SEP08462261 H 1 1816 2013 10 LG:406568.1;2000SEP083683935H 1 1822 2108 10 LG:406568.1:2000SEP085170457H1 1822 2010 17 LG:353203.1:2000SEP08590602679 1 549 11 LG:353203.1:2000SEP085906026H1 7 299 11 LG;353203.1:2000SEP085906026F6 1 609 ~

i 1 LG:353203.1:2000SEP085906026F8 7 277 11 LG:353203.1:2000SEP084569921 H 36 297 12 LG:061277.1:2000SEP081796939H 1 1 211 12 LG:061277.1:2000SEP081796939F6 1 504 12 LG:061277.1:2000SEP08g2934541 130 504 13 LG:170666.1:2000SEP083443916H1 88 361 13 LG:170666.1:2000SEP083443916F6 88 378 13 LG:170666.1;2000SEP08g4620823 258 606 13 LG:1706bb.1;2000SEP08g 1277971 1 191 13 LG;170666.1:2000SEP085834873F9 1 436 13 LG:170666.1:2000SEP085834873F8 1 470 13 LG:170666.1:2000SEP086327011 H 1 197 13 LG:170666.1;2000SEP086327111 H 1 282 13 LG:170b66.1;2000SEP086327111 F6 1 386 14 LG:311197.1;2000SEP086803514H1 503 984 14 LG:311197.1:2000SEP086803514) 1 242 823 14 ~ LG:311197.1:2000SEP086286909H2 316 799 14 LG:311197.1:2000SEP08g4568721 260 .685 14 LG:311 i 97.1:2000SEP08g3742689 209 684 14 LG:311197.1;2000SEP08g5365250 586 679 i 4 LG:311197, i :2000SEP08g5676607 451 679 14 LG:311197.1:2000SEP08g41 T 1591 263 679 14 LG:311197.1:2000SEP08g2539496 299 678 14 LG:3 i 1197,1;2000SEP08g5769156 224 677 14 LG:311197.1:2000SEP08g5232991 277 675 14 LG:311197.1:2000SEP08g3090059 202 676 14 LG:311197.1:2000SEP08g3751723 261 676 14 LG:311197.1:2000SEP08g4299176 248 676 14 LG;311197.1:2000SEP08g5630519 273 675 14 LG:311197.1:2000SEP08574367477 354 545 14 LG;311197.1;2000SEP085743674H1 1 297 14 LG;311197.1:2000SEP084127943H1 1 246 _ - __ _ ___ SEQ iD Template ID Component Start Stop NO: ID

14 LG;311197.1;2000SEP08574367487 1 183 15 LG:220655.4:2000SEP086054260H1 1 534 15 LG:220655.4;2000SEP086053961 H 1 609 15 LG:220655.4:2000SEP087397741 H 417 i 004 16 LG:1001893.1:2000SEP086339672F8 1 624 16 LG:1001893.1:2000SEP086339672H1 1 590 1 b LG;1001893.1:2000SEP08633967278 483 868 17 LG:004335.1:2000SEP08824343H 1 193 T . 2213 17 LG;004335.1;2000SEP0882434386 1931 2448 17 LG:004335.1:2000SEP08261633776 1936 2505 17 LG;004335.1;2000SEP08745151771 1961 2473 17 LG:004335.1;2000SEP08589995476 1988 2499 17 LG:004335.1;2000SEP086866173H1 2014 2149 17 LG:004335.1:2000SEP086866273H 2014 2381 17 LG;004335.1;2000SEP08g1163587 1907 2156 17 LG:004335.1:2000SEP085895088H1 1910 2161 17 LG;004335.1:2000SEP08569738578 1925 2345 17 LG:004335.1;2000SEP085899954F6 1404 1958 17 LG:004335.1:2000SEP085897061H1 1404 1695 17 LG:004335.1:2000SEP085899922H 1404 1668 17 LG;004335.1:2000SEP084821288H1 1485 1757 17 LG;004335.1:2000SEP085602937H1 1497 1759 17 LG;004335.1:2000SEP08g4194776 1578 2040 17 LG:004335.1;2000SEP085697385F9 1627 1777 17 LG:004335.1:2000SEP087608724) i 738 230 1 i 17 LG;004335.1:2000SEP08g457371 b 1771 2190 17 LG:004335.1:2000SEP08g4573707 1771 2190 17 LG;004335.1;2000SEP086566503H1 1793 2347 17 LG:004335.1:2000SEP086211870H1 1797 2076 17 LG;004335.1;2000SEP087158924H1 1801 2071 17 LG;004335.1:2000SEP087037342H1 1807 1980 17 LG:004335.1:2000SEP08569738579 1889 2470 17 LG:004335.1;2000SEP086431671 H1 1907 2436 17 LG:004335.1:2000SEP083936275H1 6l 329 17 LG:004335.1:2000SEP086392874H1 99 369 17 LG;004335.1:2000SEP084726741H1 187 433 17 LG:004335.1:2000SEP084726741 F6 187 741 17 LG;004335.1:2000SEP08695i945H1 334 909 17 LG:004335.1;2000SEP085678094H1 477 738 17 LG:004335.1:2000SEP087082061H1 483 991 17 LG;004335.1:2000SEP086923277H1 512 1037 17 LG:004335.1:2000SEP084064256H1 708 944 17 LG:004335.1:2000SEP084064256F6 708 969 17 LG:004335.1:2000SEP087608724H 743 1204 17 LG:004335.1;2000SEP086426967H1 793 1368 17 LG;004335. i ;2000SEP086886093) 821 i 401 i 7 LG:004335.1:2000SEP082616337F6 846 1256 i7 LG:004335.1:200OSEP082616337H1 846 1099 10~

SEQ ID Template ID Component Start Stop NO; ID

17 LG:004335.1:2000SEP087088351H1 927 1460 17 LG;004335.1;2000SEP086340018H1 931 1404 17 LG;004335.1;2000SEP084900977H1 976 1182 17 LG;004335.1:2000SEP084900977F9 991 1508 17 LG:004335.1:2000SEP086536713H 1 1019 1506 17 LG:004335.1:2000SEP085899231H1 1404 1686 17 LG:004335.1;2000SEP086872178H 1 1 274 17 LG;004335.1:2000SEP08g2784563 24 396 17 LG:004335.1;2000SEP086886093H 1 1 501 17 LG;004335.1:2000SEP08g2810592 1 176 17 LG:004335.1;2000SEP08g2896627 1 324 17 LG:004335.1:2000SEP08g3924468 ) 78 17 LG:004335.1;2000SEP08g4852361 1 260 17 LG;004335.1;2000SEP08g5233752 1 140 17 LG:004335.1;2000SEP082127851 H 2041 2307 17 LG;004335.1;2000SEP086436591 H 2054 2436 17 LG:004335.1:2000SEP08567809476 2073 2500 17 LG;004335.1:2000SEP08g5369879 2085 2545 17 LG;004335.1:2000SEP08g4684665 2087 2515 17 LG;004335.1;2000SEP08g3307962 2100 2544 17 LG;004335.1;2000SEP0882434376 2104 2511 17 LG:004335.1:2000SEP08g3841316 2116 2545 17 LG;004335.1;2000SEP087338633H1 2134 2538 17 LG:004335. i :2000SEP08g3162182 2 i 32 2545 17 LG:004335.1:2000SEP08g5530735 2142 2545 17 LG;004335.1;2000SEP08490097779 2175 2422 17 LG:004335.1:2000SEP08g6838724 2183 2545 17 LG:004335.1;2000SEP08g4983820 2188 2547 17 LG:004335.1;2000SEP08g4971326 2227 2543 17 LG:004335.1;2000SEP084726741 T6 2254 2512 17 LG;004335.1:2000SEP081799046H1 2259 2489 17 LG:004335.1:2000SEP08g5437793 2376 2546 17 LG:004335.1:2000SEP085878314H 1 2390 2544 18 LG:213092.b:2000SEP087394750H1 1 393 19 LG:407570.5;2000SEP082929935H1 1 288 19 LG:407570.5:2000SEP082929935F6 1 243 19 LG:407570.5;2000SEP083002522F6 19 306 19 LG:407570.5:2000SEP083002522H 1 20 329 19 LG:407570.5;2000SEP08195134976 137 634 19 LG:407570.5:2000SEP08165883876 148 531 19 LG;407570.5:2000SEP081658838F6 148 676 19 LG:407570.5;2000SEP081658838H1 148 376 20 LG:337835.8:2000SEP08g2079164 1 421 20 LG:337835.8;2000SEP084576482H1 1 119 20 LG:337835.8:2000SEP082817432H1 6 276 20 LG:337835.8:2000SEP085567451 H 10 227 20 LG:337835.8:2000SEP084631941 H1 10 271 20 LG;337835.8;2000SEP08_2444616F6 22 442 _ _ ___ lOG

SEQ ID Template ID Component Start Stop NO: ID

20 LG:337835.8:2000SEP082444b16H1 22 ~ 245 20 LG:337835.8;2000SEP083535844H1 26 307 20 LG:337835.8:2000SEP0837370bOH1 27 193 20 LG:337835.8:2000SEP085293950H2 26 155 20 LG:337835.8;2000SEP086855696H1 50 654 20 LG:337835.8:2000SEP086955392H1 69 598 20 LG:337835.8:2000SEP08g 1984989 78 309 20 LG:337835.8;2000SEP084323489H1 111 339 20 LG:337835.8;2000SEP08517888H1 119 345 20 LG:337835.8;2000SEP0863177b4H1 160 443 20 LG;337835.8;2000SEP086317732H1 160 441 20 LG:337835.8;2000SEP086317796N 1 1 bb 443 20 LG:337835.8;2000SEP08g5231782 507 975 20 LG:337835.8;2000SEP08g56b4130 522 976 20 LG:337835.8:2000SEP081439187Fb 614 988 20 LG:337835.8;2000SEP081439187H1 614. 804 20 LG:337835.8:2000SEP08g46b43b5 700 9b9 20 LG:337835.8;2000SEP08323242H1 783 984 21 LG:1099283.1:2000SEP087415b54T2 1 470 21 LG:1099283.1;2000SEP08307b753H 1 4 2b2 21 LG:1099283.1:2000SEP084018474H1 16 233 21 LG;1099283.1;2000SEP084023162H 1 14 292 21 LG:1099283.1:2000SEP084023196H 1 15 291 21 LG:1099283.1;2000SEP083825381 H 120 401 21 LG:1099283.1:2000SEP084023549H T 133 442 21 LG:1099283.1:2000SEP085107901 H1 237 468 21 LG:1099283.1:2000SEP083073301 H 2b7 356 21 LG:1099283.1:2000SEP082346304F6 1 320 21 LG:1099283.1:2000SEP08591880H1 47 228 21 LG:1099283.1;2000SEP084017491 H 67 327 21 LG:1099283.1;2000SEP084020384H1 74 357 21 LG:1099283.1:2000SEP08593233H 1 47 223 21 LG:1099283.1:2000SEP085374682H 1 70 247 22 LG:401274,2:2000SEP087004550H1 1 548 22 LG:401274.2:2000SEP08gbb1242 10 108 23 LG;222880.1;2000SEP087081513H1 1 525 23 LG:222880.1:2000SEP087757 T 59N 188 788 23 LG:222880.1:2000SEP082509720H1 252 480 23 LG:222880.1:2000SEP0873b3062H1 332 912 23 LG:222880.1:2000SEP083242083H1 367 617 23 LG:222880.1;2000SEP083644b04H T 371 666 23 LG:222880.1;2000SEP083b44604Fb 3b9 627 23 LG;222880.1;2000SEP085741818H1 407 602 23 LG:222880.1:2000SEP087082116H1 438 981 23 LG:222880.1:2000SEP08957b45R6 1748 1887 23 LG:222880.1;2000SEP08957b45Tb 1748 1844 23 LG:222880.1:2000SEP08g2930525 1757 2092 23 LG:222880.1:2000SEP08_ _77b4378H1 582 1187 SEQ ID Template ID Component Start Stop NO: ID

23 LG;222880.1:2000SEP082060770H1 626 870 23 LG;222880.1:2000SEP085113293H1 709 974 23 LG;222880, i ;2000SEP08g i 89 i 7 i 4 1 O

23 LG:222880.1:2000SEP086479360H 822 1303 23 LG:222880.1:2000SEP085784355H1 851 1113 23 LG:222880.1:2000SEP085794459H 851 1146 23 LG;222880.1:2000SEP085784455H 851 1086 23 LG:222880.1;2000SEP085784355F6 856 1391 23 LG:222880.1:2000SEP083734 i 22H 874 11 b0 23 LG;222880.1;2000SEP086832370H 874 1477 23 LG;222880.1;2000SEP086836219H 946 . 1257 23 LG;222880.1:2000SEP085104159H1 960 1199 .

23 LG;222880.1;2000SEP087757159)1 1009 1639 23 LG;222880.1;2000SEP084512707H1 1005 1260 23 LG;222880.1:2000SEP081836548H1 1055 1111 23 LG:222880.1:2000SEP081006724H 1061 1308 23 LG;222880.1;2000SEP08523339H 1 1125 1370 23 LG;222880.1:2000SEP08630148H1 1155 1437 23 LG;222880.1;2000SEP085897974H 1197 1466 23 LG;222880.1;2000SEP08459407H 1 1220 1503 23 LG:222880.1:2000SEP081930289F6 1290 1795 23 LG:222880.1;2000SEP081930289H1 1290 1560 23 LG;222880.1:2000SEP08193028976 1294 1818 23 LG;222880.1:2000SEP08578435576 1319 1729 23 LG:222880.1:2000SEP08365961876 1333 1821 23 LG:222880.1:2000SEP082762471 H 1354 1597 23 LG;222880.1:2000SEP083400826H1 1374 1601 23 LG;222880.1;2000SEP0883647867 1386 1793 23 LG:222880.1;2000SEP0884302533 1431 1885 .

23 LG:222880.1;2000SEP08954028H1 1437 1705 23 LG;222880.1;2000SEP0886398856 1471 1887 23 LG:222880.1;2000SEP0885368595 1475 1929 23 LG:222880.1;2000SEP0885662921 1485 1927 23 LG;222880.1;2000SEP0882279246 1492 _ 1887 23 LG;222880.1:2000SEP0883432804 1496 1929 23 LG:222880.1;2000SEP0883927268 1500 1897 23 LG;222880.1:2000SEP0883751389 1533 1886 23 LG:222880. i :2000SEP083028225H 1537 1818 i 23 LG:222880.1;2000SEP0883244749 1547 1892 23 LG:222880.1;2000SEP08169624176 1548 1868 23 LG:222880.1;2000SEP081696241 H 1555 1798 23 LG;222880.1:2000SEP081696241 F6 1555 1908 23 LG:222880.1;2000SEP0886471216 1558 1865 23 LG;222880.1:2000SEP0885110284 1566 2015 23 LG:222880.1:2000SEP0884373194 1573 1929 23 LG;222880. i ;2000SEP0885664143 1578 1927 23 LG:222880.1:2000SEP082293651 H 1577 1807 23 LG;222880.1;2000SEP0883 1586 1928 _ _ SE6~ Template ID Component Start Stop ID NO: ID

23 LG;222880.1;2000SEP08725947H1 1586 1829 23 LG:222880.1:2000SEP08g24013b3 1590 1887 23 LG:222880.1:2000SEP086773275) 1 1593 2143 23 LG:222880.1;2000SEP08g 1156118 1607 1887 23 LG:222880.1:2000SEP087341844H 1 1648 1888 23 LG;222880.1;2000SEP08g1892265 1660 1926 23 LG;222880.1:2000SEP08g4242906 1678 18b1 23 LG:222880.1;2000SEP085399b80H 1 1685 1882 23 LG;222880.1:2000SEP08g7b4351 1721 1940 23 LG;222880.1;2000SEP08g2716497 1722 2099 23 LG;222880.1:2000SEP08g2804847 1744 2085 23 LG:222880.1;2000SEP08957645H 1 1748 1853 23 LG;222880.1:2000SEP0895764571 1748 1844 23 LG;222880.1:2000SEP08825718H1 1893 2188 23 LG:222880.1;2000SEP083169276Fb 1906 2316 23 LG;222880.1:2000SEP083169276H1 1907 ~ 2175 23 LG;222880.1:2000SEP084880539H1 2030 2263 23 LG;222880.1:2000SEP08551186H1 2089 2335 23 LG;222880.1:2000SEP085223525H1 2144 2295 23 LG:222880.1:2000SEP087734877H1 2168 2574 23 LG:222880.1:2000SEP08g 1959837 2259 2562 23 LG:222880.1:2000SEP08331447bF6 2281 2592 23 LG:222880.1:2000SEP083314476H1 2281 2531 23 LG:222880.1:2000SEP086773275H1 2282 2747 23 LG:222880.1;2000SEP08316927676 2501 2592 23 LG:222880.1:2000SEP082134443H 1 2501 2592 24 LG:406389.1:2000SEP08g42b4177 1 472 24 LG:406389.1;2000SEP086768921 J 1 570 24 LG:406389.1:2000SEP0867676b8) 1 1 462 24 LG:406389.1:2000SEP083787648H1 382 660 24 LG:406389.1;2000SEP08g709143 395 708 24 LG:40b389.1:2000SEP08g570324 4T 1 737 24 LG:40b389.1:2000SEP08gb94218 507 733 24 LG:406389.1:2000SEP083574983H1 642 930 24 LG:406389.1:2000SEP08g 1809833 642 903 24 LG:40b389.1:2000SEP084766304H 1 690 961 24 LG;406389.1;2000SEP084766304F6 690 1 Ob2 24 LG:406389.1:2000SEP08921701 H1 920 1242 24 LG;406389.1:2000SEP087091595H1 922 1457 24 LG:40b389.1:2000SEP0847b630476 1123 1508 24 LG;406389.1:2000SEP08g3308722 1139 1550 24 LG:406389.1:2000SEP086870105H1 1141 157b 24 LG:406389.1:2000SEP086870968H 1 1145 1 bbl 24 LG:40b389.1:2000SEP08g3805b40 1178 1554 24 LG:406389.1:2000SEP08g5b1297 1217 1550 24 LG;406389.1:2000SEP08g795551 1242 1560 24 LG:40b389. T :2000SEP088683370 12b6 1550 24 LG:40b389.1:2000SEP0882141803 1393 1554 SEQ ID Template ID Component Start Stop NO: ID

24 LG;406389.1;2000SEP08478862776 1442 1509 25 LG:055461.1;2000SEP084592590H1 1 154 25 LG:0554b1.1:2000SEP084592590F8 1 566 25 LG:05546i.1:2000SEP082457736F6 14 468 25 LG:055461.1;2000SEP084194633H1 83 395 25 LG:0554b1.1:2000SEP084194633F7 87 672 25 LG:055461.1;2000SEP082073295H1 116 371 25 LG:055461.1;2000SEP082073295F6 116 472 25 LG;055461.1:2000SEP082895870H1 171 456 25 LG;055461.1;2000SEP08491179H1 219 482 25 LG;055461.1;2000SEP081400739H 280 523 25 LG;055461.1:2000SEP08228621 bRb 408 803 25 LG;0554b1.1:2000SEP082286216H1 408 591 25 LG;055461.1:2000SEP084670223H1 422 675 25 LG;055461.1;2000SEP087091663H1 710 1060 25 LG:055461.1:2000SEP084172005N 739 1009 25 LG:055461.1;2000SEP084172005F6 740 1250 25 LG;055461.1:2000SEP084054692H1 740 1019 25 LG:05546 i .1;2000SEP08240724076 i O 14 i 498 25 LG;055461.1;2000SEP08g6198775 1113 1514 25 LG:055461.1:2000SEP08g3118198 1149 1514 25 LG:0554b1.1:2000SEP081600869H1 1268 1516 25 LG;0554b1.1;2000SEP08g4329308 1292 1518 25 LG:055461.1:2000SEP08207329576 1409 1613 26 LG:979059.5:2000SEP087700332) 1 658 2b LG:979059.5:2000SEP081964843H 105 373 26 LG;979059.5:2000SEP081966204R6 112 354 26 LG:979059.5;2000SEP081966137H1 112 344 26 LG:979059.5;2000SEP081966137R6 112 570 26 LG:979059.5;2000SEP08g953428 112 , 303 26 LG:979059.5:2000SEP082542469H1 158 386 26 LG:979059.5:2000SEP08g766126 205 288 27 LG:399238.1:2000SEP08g4850653 1552 1974 27 LG:399238.1:2000SEP08g6475403 1800 1970 27 LG:399238.1:2000SEP08g3330309 1536 1967 27 LG;399238.1:2000SEP08g770433 1715 1963 27 LG:399238.1:2000SEP08g3888972 1717 1960 27 LG:399238.1:2000SEP08g4393908 1681 1961 27, LG:399238.1:2000SEP08g3843053 1681 1960 27 LG:399238.1;2000SEP081926452H 1899 1959 27 LG:399238.1:2000SEP08g3077521 1498 1959 27 LG:399238.1;2000SEP08g5877902 1486 1959 27 LG;399238.1:2000SEP08g3069392 1602 1956 27 LG:399238.1;2000SEP08g3109645 1544 1956 27 LG:399238.1:2000SEP08g2411261 1794 1956 27 LG:399238.1:2000SEP08g4083704 1511 1956 27 LG:399238.1:2000SEP08g3214844 1516 1956 27 LG:399238.1:2000SEP08g3077207 1505 1956 SE62 Template ID Component Start Stop ID NO; ID

27 LG:399238.1;2000SEP08g4394965 1568 1954 27 LG:399238.1:2000SEP08g2715285 1646 1954 27 LG;399238,1:2000SEP08g5848683 1501 1953 27 LG;399238,1;2000SEP08g4153404 1608 1952 27 LG:399238.1;2000SEP08g4901426 1490 1951 27 LG;399238,1:2000SEP087336114H1 1453 1950 27 LG:399238,1;2000SEP08g4664620 1645 1950 27 LG:399238.1;2000SEP08g3888242 1533 1950 27 LG:399238.1:2000SEP08g4682808 1494 1950 27 LG:399238.1;2000SEP08g4111172 1531 1950 27 LG;399238,1:2000SEP08g5369024 1493 1950 27 LG;399238,1:2000SEP08g5589837 1492 1950 27 LG:399238.1:2000SEP08g4394945 1492 1950 27 LG:399238.1:2000SEP08g4148390 i 53 T 1950 27 LG;399238.1:2000SEP08g3174652 1473 1949 27 LG:399238,1;2000SEP08g3095707 1756 1941 27 LG:399238.1:2000SEP083930103T6 1409 1924 27 LG;399238.1:2000SEP08g2992787 1636 1914 27 LG;399238, 7 :2000SEP082102303T6 1318 1912 27 LG:399238.1:2000SEP082673478T6 1598 1912 27 LG:399238.1:2000SEP0828 T 60 T 1574 1866 27 LG;399238.1:2000SEP08g4311150 1479 1826 27 LG:399238.1;2000SEP087102476H1 1528 ~ 1776 27 LG:399238.1:2000SEP08g201 6852 1442 1727 27 LG;399238.1;2000SEP083431253H1 1392 1641 27 ~ LG:399238.1;2000SEP083554944H 1 1352 1633 27 LG:399238,1:2000SEP083222446H 1 1282 1579 27 LG:399238.1:2000SEP08210230386 T 206 T 53 T

27 LG:399238.1:2000SEP082100380H1 1238 1511 27 LG:399238,1:2000SEP081213990H 1 1230 1454 27 LG;399238,1;2000SEP085005692H1 1148 1400 27 LG:399238.1:2000SEP082673478F6 1077 1383 27 LG:399238.1;2000SEP08g49911 b5 910 1367 27 LG:399238,1;2000SEP08g3151254 1094 1367 27 LG:399238.1:2000SEP084717584Th 954 1362 27 LG:399238.1:2000SEP084739746Th 1034 1362 27 LG;399238,1:2000SEP083930187F8 813 1357 27 LG;399238,1:2000SEP082102303H 1 1194 1351 27 LG:399238,1:2000SEP082673478H 1 1077 1331 27 LG:399238,1:2000SEP087625076) 1 653 1175 27 LG:399238,1;2000SEP08g770134 993 1170 27 LG:399238,1:2000SEP086316289H 1 997 11 b8 27 LG:399238.1:2000SEP086551645H1 577 1164 27 LG;399238.1:2000SEP083930103F6 813 1152 27 LG:399238.1:2000SEP083784920H1 804 1113 27 LG:399238.1:2000SEP086802648) 1 486 1080 27 LG:399238.1:2000SEP08137215H1 832 1017 27 LG;399238,1:2000SEP083930103H1 813 929 SEQ ID Template ID Component Start Stop NO; ID

27 LG;399238.1:2000SEP087625076H1 1 650 27 LG;399238.1;2000SEP084717584F6 135 522 27 LG:399238.1:2000SEP086802648H 2 310 27 LG;399238.1:2000SEP083454431 H2 30 282 27 LG:399238.1;2000SEP083293457H1 8 273 27 LG:399238.1:2000SEP084717584H1 135 213 28 LG: l 382945.7:2000SEP086006836H 185 471 28 LG:1382945.7:2000SEP084642496T8 1 453 28 LG;1382945.7:2000SEP08464249679 116 572 ~

29 LG:i3836i0.3:2000SEP083552107H1 1469 1615 29 LG;1383610.3:2000SEP086815380H 291 707 29 LG:1383610.3:2000SEP083321944F6 431 931 29 LG;1383610.3:2000SEP083321944H 431 651 29 LG:1383610.3:2000SEP082857659H 434 553 29 LG:1383610.3:2000SEP08279555H1 459 518 29 LG:1383610.3;2000SEP08g672824 478 659 29 LG:1383610.3:2000SEP08g672823 478 659 29 LG:1383610.3:2000SEP087035734H 494 640 29 LG;1383610.3:2000SEP083925445H 522 718 29 LG;1383610.3:2000SEP083925445F6 522 1030 29 LG:1383610.3:2000SEP08682691 H 573 754 29 LG:1383610.3:2000SEP084586429H 581 801 l 29 LG:1383610.3;2000SEP085883541 H1 584 859 29 LG:1383610.3:2000SEP08' 5881487H1 584 844 29 LG;1383610.3;2000SEP085890387H1 585 829 29 LG:1383610.3:2000SEP085157959H1 659 928 29 LG;1383b10.3:2000SEP081789327H1 680 927 29 LG:1383610.3:2000SEP086819005H1 742 849 29 LG;1383610.3:2000SEP082569594H 676 928 29 LG;1383610.3;2000SEP084691317H1 693 951 29 LG:1383610.3:2000SEP08236264086 737 1258 29 LG;1383610.3:2000SEP082362640Hi 693 934 29 LG:1383610.3;2000SEP084617404H1 700 948 29 LG;1383610.3:2000SEP086964192H1 749 837 29 LG;1383610.3:2000SEP086964292H 741 1138 29 LG:138361 0.3:2000SEP085888984H 829 992 29 LG:1383610.3:2000SEP085559661H1 765 870 29 LG:1383610.3:2000SEP081368378H1 765 886 29 LG:1383610.3:2000SEP086307006H 766 987 29 LG:1383610.3:2000SEP082939651 H 828 926 l 29 LG:1383610.3;2000SEP08164944576 1317 1573 29 LG:1383610.3:2000SEP08539686671 1318 1596 29 LG:1383610.3;2000SEP08g2819781 1326 1624 29 LG: l 383610.3:2000SEP083129583H 1328 1 6l 29 LG;1383610.3:2000SEP08g2178818 1352 1617 29 LG;1383610.3:2000SEP08g6993030 1388 1615 29 LG;1383610.3:2000SEP08141412576 1 500 1 577 29 LG:1383610.3:2000SEP081414125H 1501 1554 SEQ ID Template ID Component Start Stop NO: ID

29 LG;1383610.3:2000SEP081414125F6 1501 1615 29 LG;1383610.3;2000SEP085679149H1 1502 1775 29 LG:1383610.3;2000SEP08g 1264772 1528 1619 29 LG:1383b10.3;2000SEP082760888H1 1698 1919 29 LG:1383610.3;2000SEP08276088886 1699 1949 29 LG:1383b10.3;2000SEP085726387H1 1805 1872 29 LG:1383b10.3:2000SEP08276088876 1848 2434 29 LG;1383610.3;2000SEP08g817671 2235 2485 29 LG:1383610.3:2000SEP0809386586 2363 2638 29 LG;1383610.3;2000SEP08g5175836 2448 2600 29 LG:1383610.3:2000SEP083418916H1 291 526 29 LG;1383610.3;2000SEP08g4243476 1300 1 6l 29 LG:1383610.3:2000SEP085038137F6 1 429 29 LG;1383610.3;2000SEP085038i37H1 1 236 29 LG:1383b10.3;2000SEP081639525H1 1146 1339 29 LG:1383610.3;2000SEP08g5435989 1223 1622 29 LG:1383610.3;2000SEP085792723H1 1223 1519 29 LG:1383b10.3:2000SEP08g3923642 1240 1622 29 LG;1383610.3;2000SEP08266860876 1251 1578 29 LG;1383b10.3:2000SEP08g1055507 1279 1617 29 LG;1383b10.3:2000SEP08g3095471 1296 1622 29 LG:1383b10.3;2000SEP081639525F6 1204 1598 29 LG:1383610.3;2000SEP08g2617139 1469 1615 29 LG:1383610.3:2000SEP08g2553584 1145 1583 29 LG:1383610.3;2000SEP08'5487273H1 1143 1389 29 LG:13836i0.3;2000SEP08043657H1 1087 1391 29 LG:1383610.3:2000SEP0899019371 l 1 b0 1577 29 LG:1383610.3;2000SEP083959408H1 1163 1451 29 LG;1383b10.3:2000SEP08g2824450 1174 1621 29 LG:1383610.3;2000SEP08g4136922 1175 1618 29 LG:1383610.3;2000SEP08g1727608 1180 1618 29 LG:1383b10.3;2000SEP08503813776 1180 1732 29 LG;1383610.3:2000SEP08g3933824 1181 1623 29 LG:1383610.3;2000SEP08163952576 1197 1578 29 LG:1383610.3:2000SEP08g2265436 1555 1615 29 LG;1383610.3:2000SEP085175102F6 838 1322 29 LG;1383610.3;2000SEP085175102H1 838 966 29 LG:1383610.3:2000SEP085613424H1 817 1058 29 LG:1383610.3:2000SEP084638701 H 820 1082 29 LG;1383610.3;2000SEP083904031 H 828 1112 29 LG:1383610.3:2000SEP084229042H1 863 1129 29 LG;1383610.3:2000SEP086817269H 914 1315 29 LG;1383610.3:2000SEP083164238H 925 1188 29 LG:1383610.3:2000SEP084443014H 927 1203 29 LG;1383610.3:2000SEP084856855H 928 1183 29 LG:1383610.3:2000SEP084081134H 939 1183 29 LG:1383610.3:2000SEP086717283H1 999 1496 29 LG:1383610.3:2000SEP08332194476 1007 1564 SEQ ID Template ID Component Start Stop NO: ID

29 LG;1383610.3:2000SEP086352656H 953 1239 29 LG:1383b10.3:2000SEP086315818H1 1061 1320 29 LG:1383610.3:2000SEP08357758H 1 984 1229 29 LG: T 3836 T 0.3:2000SEP084369314H 950 1155 T

29 LG:1383b10.3;2000SEP08476559H1 998 1274 29 LG:1383610.3:2000SEP083902993H1 1033 1296 29 LG:1383b10.3:2000SEP08259131 F1 1034 1615 29 LG:13836T0.3;2000SEP086067265H1 1038 1589 29 LG;1383610.3:2000SEP08904451 H 1006 1276 29 LG:1383b10.3;2000SEP082668608F6 1054 1545 29 LG;1383610.3;2000SEP084320682H1 1002 1261 29 LG:1383610.3;2000SEP085287774H1 1004 1258 29 LG:1383610.3:2000SEP08236264076 1066 1573 29 LG;1383610.3:2000SEP08g 1423037 1011 1325 29 LG:1383610.3;2000SEP08938741 R1 1073 1587 29 LG;1383610.3:2000SEP08938741 T1 1073 1571 29 LG;1383610.3:2000SEP08938741 H 1015 1297 29 LG:1383610.3:2000SEP08g2030629 1015 1351 29 LG;1383b10.3;2000SEP085741851H1 1017 1302 29 LG;1383610.3:2000SEP084460572H1 1017 1278 29 LG;1383610.3:2000SEP081923660H1 1022 1297 29 LG;1383610.3;2000SEP08192366076 1080 1576 29 LG:1383610.3;2000SEP08192366086 1080 1585 29 LG;13836T0.3;2000SEP085730070H1 7082 1615 29 LG:1383b10.3:2000SEP083483646H1 1132 1447 29 LG:1383b10.3:2000SEP08225790786 1087 1577 29 LG;1383610.3;2000SEP082257907H1 1087 1323 29 LG;1383610.3:2000SEP081238605H 1031 1178 29 LG:1383b10.3:2000SEP081792952H1 1033 1307 29 LG:1383610.3;2000SEP08156151276 1096 1564 29 LG:1383610.3:2000SEP082409081H1 1052 1294 29 LG;1383610.3:2000SEP08517510276 1117 1605 29 LG:1383610.3:2000SEP08g2553606 1124 161 b 29 LG:1383610.3:2000SEP08225790776 1132 1593 29 LG;1383610.3:2000SEP083369566H1 1079 1359 29 LG:1383b10.3:2000SEP08g2958446 1143 1624 29 LG:1383610.3:2000SEP086053157) 798 1369 29 LG:1383610.3;2000SEP082745126H1 794 1024 29 LG;1383610.3:2000SEP087620203) 813 1367 29 LG:1383610.3:2000SEP084717276H1 767 845 29 LG;1383610.3:2000SEP086739535H 736 7299 29 LG;1383610.3:2000SEP082235421H1 1540 1615 29 LG:1383610.3:2000SEP08g2725931 1476 1615 29 LG:1383610.3:2000SEP086405358H1 1547 1615 29 LG;1383b10.3;2000SEP082234402H1 1540 1615 29 LG:1383610.3:2000SEP082241280H1 1540 1615 30 LG:1384030.1:2000SEP086777156H 365 873 30 LG:1384030.1;2000SEP086456081 H 378 945 SEQ ID Template ID Component Start Stop NO: ID

30 LG;1384030.1:2000SEP08g813592 521 841 30 LG: i 384030.1:2000SEP081241458H 623 859 30 LG:1384030.1:2000SEP083232547H1 636 856 30 LG:1384030.1;2000SEP087740771 J bbl 1204 30 LG;1384030,1:2000SEP084226494H1 1925 2192 30 LG:1384030.1:2000SEP08279281776 1610 2152 30 ~LG:1384030.1;2000SEP08g1156926 1945 2192 30 LG;1384030.1;2000SEP08228462376 1975 2440 30 LG:1384030,1;2000SEP083084794H1 2008 2284 30 LG:1384030.1:2000SEP08g3149789 2021 2489 30 LG;1384030.1:2000SEP082685272H1 2048 2192 30 LG:1384030,1;2000SEP08g2955029 1752 2063 30 LG:1384030.1;2000SEP08g3962206 1755 2198 30 LG:1384030,1:2000SEP08766404H 1 1763 2008 30 LG:1384030.1:2000SEP08g2786198 1767 2198 30 LG:1384030,1:2000SEP086365044H1 1794 2063 30 LG;1384030,1:2000SEP08g2215615 1823 2192 30 LG:1384030,1:2000SEP08g 1948592 1370 1648 30 LG:1384030.1:2000SEP08g 1948812 1399 1675 30 LG:1384030.1:2000SEP086442338H1 1434 1968 30 LG:1384030,i;2000SEP08744753672 1486 2085 30 LG:1384030,1;2000SEP086777364H 80 303 30 LG;1384030.1:2000SEP083855585F6 98 610 30 LG;1384030,1;2000SEP08741974H 1 153 300 30 LG:1384030.1:2000SEP086777364J 80 303 30 LG;1384030.1;2000SEP083341227H 155 405 30 LG;1384030,1;2000SEP083341227F6 156 777 30 LG:1384030.1:2000SEP086906377H1 357 857 30 LG:1384030.1:2000SEP086778372H 365 946 30 LG:1384030.1;2000SEP084228325H1 1925 2192 30 LG;1384030,1:2000SEP08744925472 1501 2113 30 LG;i384030,1;2000SEP083822349H1 1563 1841 30 LG:1384030.1:2000SEP086159726H1 1600 1799 30 LG:1384030,1:2000SEP08334122776 1608 2057 30 LG;1384030.1:2000SEP085173885H1 1097 1347 30 LG;1384030.1:2000SEP085926007H1 1098 1398 30 LG:1384030.1;2000SEP086839205H1 1103 1632 30 LG:1384030.i:2000SEP084953785H1 1250 1497 30 LG;1384030.1;2000SEP087607682J1 1279 1820 30 LG;1384030,1;2000SEP086051418J1 1328 1823 30 LG:1384030.1:2000SEP086051418H1 1328 1795 30 LG;1384030.1:2000SEP085266960H1 1363 1625 30 LG:1384030,1:2000SEP08g2022434 667 903 30 LG:1384030,1:2000SEP08g892844 685 1082 30 LG;1384030.1;2000SEP08g4265266 703 1132 30 LG:1384030,1:2000SEP08g2838388 753 1199 30 LG:1384030.1:2000SEP082792817F6 794 1342 30 LG:1384030.1:2000SEP08g2215668 819 1227 SEQ ID Template ID Component Start Stop NO: ID

30 LG:1384030.1:2000SEP083250390H 926 1239 30 LG:1384030.1:2000SEP086777156J1 790 1387 30 LG:1384030.1;2000SEP082792817H1 793 1083 ~

30 LG:1384030.1;2000SEP087225486H 27 527 30 LG:1384030.1:2000SEP081648239H1 28 249 30 LG:1384030.1;2000SEP086482181 H1 63 537 30 LG:1384030.1;2000SEP087607682H 67 401 30 LG:1384030.1:2000SEP087236586H 77 459 30 LG:1384030.1;2000SEP08g6199353 1945 2196 30 LG:1384030.1:2000SEP08g3230137 i 744 2196 30 LG;1384030.1:2000SEP081601902H1 2095 2294 30 LG:1384030.1;2000SEP081601960F6 2095 2462 30 LG:1384030.1;2000SEP081601960H1 2095 2295 30 LG:1384030.1;2000SEP08281324176 2200 2428 30 LG;1384030.1:2000SEP082813241F6 2207 2466 30 LG:1384030.1:2000SEP082813241H1 2207 2420 30 LG:1384030.1;2000SEP082813110H1 2207 2415 30 LG:1384030.1:2000SEP08160196076 2285 2420 30 LG:1384030.1:2000SEP08g5706950 2073 2473 30 LG:1384030.1;2000SEP08' 1648239F6 28 404 30 LG:1384030. i :2000SEP08486891 H 30 278 30 LG;1384030.1;2000SEP083984662H 44 175 30 LG;1384030.1;2000SEP08~ 1839976H 45 215 30 LG:1384030.1;2000SEP087345515H1 50 582 30 LG:1384030.1:2000SEP083984662F7 b0 619 30 LG:1384030.1;2000SEP08g4005994 1825 2192 30 LG:1384030.1:2000SEP08g5177997 1829 2192 30 LG;1384030.1:2000SEP08g2873855 1828 2192 30 LG:1384030.1;2000SEP08g 1110202 1831 2192 30 LG:1384030.1:2000SEP08g 1 O 14137 1840 2187 30 LG:1384030.1:2000SEP08g4095889 1856 2192 30 LG; i 384030.1:2000SEP08g224 i 937 1862 2191 30 LG:1384030.1;2000SEP08g892736 1884 2208 30 LG:1384030.1:2000SEP08g2541551 1883 2178 30 LG;1384030.1:2000SEP08265663H1 b3 248 30 LG:1384030.1:2000SEP08291443H1 1045 . 1342 30 LG:1384030.1:2000SEP087740771H1 1074 1709 30 LG:1384030.1;2000SEP08279627476 1632 2144 30 LG:1384030.1:2000SEP08228462386 1635 2025 30 LG;1384030.1:2000SEP082284623H1 1635 ~ 1869 30 LG;1384030.1:2000SEP08781773H 1 1711 1953 30 LG;1384030.1;2000SEP08519946H1 1715 1951 30 LG:1384030. i :2000SEP08164823976 1720 2155 30 LG;1384030.1:2000SEP08385558576 1734 2144 30 LG:1384030.1:2000SEP08g3797322 1739 2192 30 LG: i 384030.1:2000SEP08g813504 1916 220 i 30 LG:1384030.1:2000SEP084352811H1 1888 2113 30 LG:1384030.1:2000SEP08__ 2832028H2 1 260 SEQ ID Template ID Component Start Stop NO: ID

30 LG;1384030.1:2000SEP085480213H1 23 206 30 LG:1384030.1:2000SEP085478431 H 23 275 31 LG:390475.1:2000SEP08373158H 1 1425 1612 31 LG:390475.1:2000SEP08802683H1 1432 1636 31 LG;390475.1:2000SEP08467131H1 1461 1661 31 LG:390475.1;2000SEP08374250H 1 1424 1672 31 LG;390475.1:2000SEP08468011 H 1455 1688 31 LG;390475.1;2000SEP085680194H1 1523 1715 31 LG:390475.1;2000SEP082005982H1 1465 1658 31 LG;390475.1:2000SEP08g1203616 1490 1690 31 LG;390475.1:2000SEP081942223H1 1461 1697 31 LG:390475.1:2000SEP081875616H1 1509 1682 31 LG:390475.1:2000SEP081562493H1 1468 1694 31 LG;390475.1:2000SEP083321585H2 1490 1572 31 LG:390475.1:2000SEP08430766H1 1475. 1679 31 LG:390475.1:2000SEP08467859H1 1532 1630 31 LG:390475.1:2000SEP083916709H 1638 1931 31 LG;390475.1:2000SEP08g4457738 527 669 31 LG;390475.1;2000SEP08g1384862 537 684 31 LG;390475.1;2000SEP08g1242860 382 665 31 LG:390475.1:2000SEP08g766144 383 634 31 LG;390475.1:2000SEP08067238H1 392 551 31 LG;390475.1:2000SEP08633651 H 399 653 31 LG:390475.1:2000SEP081403384H1 399 604 31 LG;390475.1;2000SEP082209992H1 402 510 31 LG:390475.1;2000SEP08g787869 412 660 31 LG;390475.1:2000SEP08g2835653 418 663 31 LG:390475.1:2000SEP08043054H 1 424 709 31 LG;390475.1:2000SEP08g1274002 428 962 31 LG:390475.1:2000SEP08g3677757 443 671 31 ~ LG:390475.1:2000SEP08g3743491 250 438 31 LG:390475.1:2000SEP082923096H 251 474 1 v 31 LG:390475.1:2000SEP083249704H 291 431 31 LG:390475.1:2000SEP081338497H1 309 441 31 LG:390475.1;2000SEP083494313H1 325 467 31 LG:390475.1;2000SEP08g2820741 335 701 31 LG;390475.1;2000SEP084714287H1 365 607 31 LG;390475.1:2000SEP08511973H1 372 566 31 LG;390475.1:2000SEP083955111 H1 1182 1456 31 LG:390475.1:2000SEP08275438H1 1239 1434 31 LG:390475.1:2000SEP084539568H 1190 1442 31 LG:390475.1;2000SEP083919091 H 1195 1434 31 LG:390475.1:2000SEP082840455H 1203 1482 31 LG:390475.1:2000SEP08276868H 1 1238 1467 31 LG:390475.1;2000SEP08778666H1 1155 1385 31 LG:390475.1;2000SEP08024765H1 1156 1346 31 LG:390475.1;2000SEP08g723508 1169 1314 31 LG:390475.1:2000SEP08805277H1 1169 1391 SEQ ID Template ID Component Start Stop NO; ID

31 LG:390475.1;2000SEP08g844491 1173 1495 31 LG:390475.1;2000SEP08g735070 1173 1416 31 LG:390475.1:2000SEP082290953H 1 1 1 73 1395 31 LG:390475. 1 :2000SEP084295636H 1 1126 1241 31 LG;390475.1:2000SEP086964476H1 1124 1272 31 LG;390475.1;2000SEP0842957 1 5H 1125 1373 31 LG;390475.1;2000SEP086519762H1 1150 1246 31 LG:390475.1;2000SEP08g 1357998 1143 1722 31 LG;390475.1:2000SEP082263032H1 1155 1393 31 LG:390475.1; 2000SEP08g6 1 7641 1 68 414 31 LG;390475.1:2000SEP082044802H1 185 354 31 LG;390475.1;2000SEP08g1958504 199 404 31 LG:390475.1:2000SEP08540922H1 223 442 3 1 LG:390475.1;2000SEP082770791 H 248 479 31 LG:390475.1;2000SEP08g 1873997 1 177 .

31 LG:390475.1:2000SEP084084288H1 8 189 31 LG:390475.1:2000SEP082174238H1 8 159 31 LG:390475.1;2000SEP081446053H1 9 264 31 LG:390475.1:2000SEP085298475H 1 9 246 31 LG;390475.1:2000SEP084341605H1 17 234 31 LG:390475.1:2000SEP084145764H 1 18 214 31 LG:390475.1:2000SEP0847 1 3341 19 141 31 LG;390475.1;2000SEP086441361 H 28 1 69 31 LG:390475.1:2000SEP081001468H1 40 276 31 LG:390475.1:2000SEP082723346H1 42 281 31 LG:390475.1:2000SEP081450049H 1 58 259 3i LG;390475.1:2000SEP081839414H1 59 293 31 LG;390475.1;2000SEP08g1364559 73 403 31 LG:390475.1;2000SEP08907971 H1 66 283 31 LG:390475.1:2000SEP08g3182476 8b 319 31 LG:390475.1:2000SEP082475265H1 86 306 31 LG:390475.1;2000SEP085965283H 1 109 264 31 LG:390475.1;2000SEP083580918H1 120 403 31 LG;390475.1;2000SEP083296172H1 1 176 3i LG:390475.1;2000SEP082130474H1 1 246 31 LG:390475.1:2000SEP083369963H1 1 237 31 LG:390475.1:2000SEP082494290H1 1 258 31 LG:390475.1;2000SEP083470236H 1 1 2l 1 31 LG:390475.1:2000SEP081839015H 1 1 117 31 LG;390475.1:2000SEP08630829H1 1 262 31 LG;390475.1:2000SEP083051970H1 1 242 31 LG;390475.1:2000SEP083961074H2 1 224 31 LG:390475.1:2000SEP082947052H2 1 215 31 LG:390475.1:2000SEP081 322474H 1 194 31 LG:390475.1:2000SEP081466377H1 1 157 31 LG;390475.1:2000SEP081561545H1 1 1b2 31 LG:390475.1:2000SEP083685341 Hi 1 246 31 LG:390475.1;2000SEP08g1336967 811 1059 IlS

SEQ ID Template ID Component Start Stop NO: ID

31 LG;390475. i :2000SEP08g 1303305 812 929 31 LG:390475.1;2000SEP08795097H1 764 930 31 LG;390475.1:2000SEP08499861 H 1 553 671 31 LG:390475.1:2000SEP082857203H1 556 642 31 LG:390475.1:2000SEP08g 1146853 562 700 31 LG:390475.1:2000SEP0834661 32H 578 692 1 ~

31 LG;390475.1:2000SEP08452754H1 1095. 1326 31 LG:390475.1:2000SEP086962745H1 1091 1286 31 LG:390475, 1 :2000SEP08g 1983447 1272 T 512 31 LG:390475.1:2000SEP08302583H1 1272 1511 31 LG;390475.1:2000SEP082279888H1 1271 1517 31 LG:390475.1:2000SEP084354187H1 1267 1504 31 LG:390475.1:2000SEP081225050H 1 1269 1507 31 LG:390475.1:2000SEP08869885H T 1241 T 478 31 LG:390475.1:2000SEP08g918854 1262 1679 31 LG:390475.1;2000SEP082007247H1 1256 1422 3 1 LG:390475.1:2000SEP08g 1025808 1263 1493 31 LG;390475.1;2000SEP085218231 H 1267 1502 31 LG:390475.1:2000SEP08674150H1 1240 1497 31 LG;390475.1;2000SEP083877381 N 1307 1 508 31 LG:390475.1;2000SEP087650404H2 ~ .1309 1910 31 LG:390475.1:2000SEP082761640H 1 1319 1541 3 1 LG:390475.1:2000SEP081 21 b 133H 1349 1507 31 LG;390475.1:2000SEP083208733H1 1336 1591 31 LG:390475.1:2000SEP082489552N 1 1339 1 546 31 LG:390475.1:2000SEP082591840H1 1353 1590 31 LG;390475.1:2000SEP08146677H1 1286 1414 31 LG:390475.1:2000SEP08l9bOb80H1 1288 1487 31 LG:390475.1:2000SEP082298738H1 1297 1548 3l LG; 390475. T 4976830H 1 1294 1451 :2000SEP08 31 LG:390475.1:2000SEP081289679H T 1292 1536 31 LG:390475. 1 :2000SEP082480383H 1 1 1 b8 31 LG:390475.1:2000SEP083697730H1 2 228 31 LG:390475. 1 :2000SEP0824421 O1 H 1 164 31 LG:390475.1:2000SEP083267911 N 1 190 3i LG:390475.1;2000SEP08g1801609 1 258 31 LG:390475.1:2000SEP082304464H1 1 213 31 LG:390475.1;2000SEP083348740H1 1 201 31 LG:390475.1:2000SEP08g 1395505 1281 1442 31 LG:390475.1:2000SEP08552037H 1 1283 1 510 31 LG:390475. 1 :2000SEP08321116N 1 1 281 1518 31 LG:390475.1;2000SEP084652332N 1 1273 1489 31 LG:390475.1:2000SEP08g 1576768 1274 1437 31 LG;390475.1:2000SEP082532160H1 1279 1530 31 LG:390475.1:2000SEP081413859H1 1276 1527 31 LG:390475.1:2000SEP083992247H1 826 1100 31 LG:390475.1:2000SEP086443848H 1 880 1408 31 LG:390475.1:2000SEP08g 1640782 823 970 _ ___ _ _ .

SEQ ID Template ID Component Start Stop NO: ID

31 LG;390475.1;2000SEP087254474H1 926 1362 31 LG:390475.1;2000SEP086967258H 1 926 i 060 31 LG:390475.1:2000SEP08696231 6H 926 1321 31 LG:390475.1; 2000SEP086961986H 1 926 1392 31 LG:390475.1:2000SEP08431342H 1 971 1206 31 LG:390475.1:2000SEP083534814H1 1018 1188 31 LG:390475.1:2000SEP082288879H 1 1041 1278 31 LG:390475.1:2000SEP082410736H1 1070 1303 31 LG:390475.1:2000SEP08g395465 1081 1409 31 LG:390475.1:2000SEP082727033H1 1086 1317 31 LG:390475.1:2000SEP08g 1295586 1414 1 bbl , 31 LG:390475.1:2000SEP08g 1312999 1415 1672 31 LG:390475.1:2000SEP08530963N i 1406 1624 31 LG:390475.1;2000SEP08855339H1 1396 1634 31 LG:390475.1:2000SEP085962214N 1 1363 1526 31 LG:390475.1:2000SEP08452967H1 1366 1583 31 LG:390475.1:2000SEP081421903H1 1372 1545 32 LG;229105.3:2000SEP087435272Hi 1 596 32 LG;229105.3:2000SEP085835361H1 323 592 32 LG:229105.3:2000SEP087435218H1 1 596 32 LG;229105.3:2000SEP085835361 F6 323 712 33 LG:232578.3:2000SEP08g6663427 1120 1412 33 LG:232578.3:2000SEP08g3279586 i 080 i 417 33 LG;232578.3:2000SEP08g1384308 1026 1417 33 LG:232578.3;2000SEP08g1224514 1068 1416 33 LG:232578.3:2000SEP08g1365326 905 1417 33 LG;232578.3:2000SEP08g3674482 965 1417 33 LG:232578.3:2000SEP08g2810626 1034 1416 33 LG:232578.3:2000SEP08g2901324 957 1416 33 LG;232578.3:2000SEP08g6073460 1272 1417 33 LG;232578.3:2000SEP08g 151 b 131 11 b7 141 b 33 LG:232578.3:2000SEP08g 1390751 1093 1418 33 LG:232578.3:2000SEP08g2583395 970 141 b 33 LG:232578.3;2000SEP08g1712889 1123 ~ 1419 33 LG;232578.3:2000SEP08g3182153 1076 1419 33 LG:232578.3:2000SEP08g 1388644 1126 14 i 33 LG:232578.3:200DSEP08g3331087 1162 1418 33 LG:232578.3:2000SEP08g6041357 1120 1418 33 LG:232578.3:2000SEP08g4457829 1310 1419 33 LG:232578.3:2000SEP08g333 i 089 1058 1418 33 LG:232578.3:2000SEP08g4080845 1013 1424 33 LG:232578.3:2000SEP08g5450749 1028 1423 33 LG:232578.3:2000SEP08g3842825 1201 1420 33 LG:232578.3:2000SEP08g5527989 1022 1419 33 LG:232578.3:2000SEP08g5858042 1024 1420 33 LG:232578.3;2000SEP08g2540076 1086 1420 33 LG:232578.3:2000SEP083838381H1 827 1089 33 LG:232578.3:2000SEP084640194H 1 845 1077 SEQ ID Template ID Component Start Stop NO: ID

33 LG;232578.3:2000SEP082342771 H 849 1063 33 LG:232578.3;2000SEP08386912bH1 814 1030 33 LG:232578.3:2000SEP08557 05686 615 1006 33 LG:232578.3:2000SEP08551056H 1 580 788 33 LG:232578.3:2000SEP08g 1978109 458 764 33 LG;232578.3;2000SEP083475224H1 319 650 33 LG:232578.3;2000SEP085523539H1 569 643 33 LG:232578.3;2000SEP08g2818319 132 489 33 LG:232578.3:2000SEP08725294bH 1 381 33 LG:232578.3;2000SEP087252946) 1 381 33 LG:232578.3:2000SEP08i 44b4bOH 46 288 33 LG:232578.3:2000SEP08g897273 i 167 1400 33 LG:232578.3;2000SEP08181975776 860 1399 33 LG:232578.3;2000SEP08g3178b43 912 1383 33 LG:232578.3;2000SEP08279342876 85b 1378 33 LG:232578.3:2000SEP08g2432b83 960 1371 33 LG;232578.3:2000SEP0837288b4H1 1062 1368 33 LG;232578.3:2000SEP08191534bH ' 1106 13b7 33 LG:232578.3:2000SEP08542238378 834 1176 33 LG:232578.3;2000SEP08744755372 690 1334 33 LG:232578.3:2000SEP08278007H i 1004 1334 33 LG;232578.3:2000SEP085980881H1 1003 1317 33 LG:232578.3:2000SEP082048520H 1045 i 301 33 LG:232578.3:2000SEP082b21273H 1022 1268 i 33 LG;232578.3;2000SEP08275474H1 1006 1224 33 LG:232578.3:2000SEP08286329576 880 1140 33 LG:232578.3:2000SEP08g 1425453 1093 1409 33 LG:232578.3:2000SEP08549352F1 903 1412 33 LG:232578.3:2000SEP08g3037b24 1243 1409 33 LG;232578.3:2000SEP08g5392b54 1303 1403 33 LG:232578.3:2000SEP08g607b333 1122 1416 33 LG:232578.3;2000SEP08g3754744 1083 1416 33 LG:232578.3:2000SEP08g 1729139 1047 1415 33 LG:232578.3;2000SEP08g45650b8 1341 1416 33 LG;232578.3;2000SEP08g6451170 1159 1416 33 LG;232578.3:2000SEP08g i 425344 1 i 27 1416 33 LG;232578.3:2000SEP08g4074741 1010 1415 33 LG:232578.3:2000SEP082847751 H 1218 1402 33 LG;232578.3;2000SEP08g5813374 1000 1087 33 LG:232b78.3:2000SEP08891702H1 9b2 1223 33 LG:232578.3;2000SEP08g6228941 951 1106 33 LG:232578.3:2000SEP086323b71 T8 885 1311 34 LG:1166387.9:2000SEP087684091 H1 1 490 34 LG:116b387.9:2000SEP087682011 H2 1 655 34 LG:1166387.9:2000SEP087207248H 1 608 34 LG:1166387.9:2000SEP08' 6963062H1 1 44i 34 LG;11 b6387.9:2000SEP086961001 H 1 312 34 LG:1166387.9:2000SEP08721035 i 1 626 H i _ _ _ , 121- __ _ SEQ ID Template ID Component Start Stop NO; ID

34 LG;1166387.9:2000SEP086966266H 1 1 513 34 LG;1166387.9:2000SEP08720721 OH 1 607 34 LG;1166387.9:2000SEP087211091 H 1 586 34 LG:1166387.9:2000SEP086289389H2 1 171 34 LG:1166387.9:2000SEP087208863H 1 1 556 34 LG:1166387,9;2000SEP087209326Hi 1 573 34 LG: ) 166387.9:2000SEP083580915H 1 36 324 34 LG:1166387.9:2000SEP087207309H 1 104 588 34 LG:1166387.9:2000SEP084759262F6 136 458 34 LG:116b387.9;2000SEP084759262H1 189 457 34 LG;116b387.9:2000SEP085664088H 1 381 648 34 LG;1166387.9:2000SEP082733526H 1 501 772 34 LG:1166387.9:2000SEP082763906H 1 625 862 35 LG:351357.1:2000SEP0883078297 743 1080 35 LG:351357,1:2000SEP087677606J 1 996 1463 35 LG:351357.1:2000SEP0882577431 9 341 35 LG;351357,1:2000SEP087369934H1 13 605 35 LG:351357.1;2000SEP087370474H1 12 598 35 LG:351357.1:2000SEP0885440203 173 592 35 LG;351357,1;2000SEP087463274H1 291 871 35 LG:351357.1:2000SEP0885440947 1 429 35 LG:351357.1:2000SEP0882553543 2 443 35 LG;351357.1;2000SEP0882590051 6 433 35 LG:351357,1:2000SEP087677606H 1 1 587 35 LG:351357.1;20005EP0881989041 1118 1417 36 LG:465592,1:2000SEP084567709H1 1 272 36 LG;465592,1:2000SEP081897368H 1 i 239 36 LG:4b5592,1;2000SEP084567709F6 82 307 36 LG;465592.1:2000SEP084551518H 1 161 4i 2 36 LG:465592.1;2000SEP0885111406 229 703 36 LG:465592.1:2000SEP084779885H1 5 297 36 LG:465592,1;2000SEP084779885F7 5 501 36 LG:465592,1:2000SEP085207964T6 648 749 36 LG:465592.1;2000SEP08g 1005124 393 656 37 LG:OOb848.5:2000SEP0886462516 353 731 37 LG:OOb848.5:2000SEP085184275H1 626 732 37 LG:006848.5:2000SEP086311035H1 1 579 37 LG:OOb848,5;2000SEP086308035H1 1 489 37 LG;006848.5:2000SEP085824936H1 418 732 37 LG:OOb848.5:2000SEP08550415Th 449 697 37 LG:OOb848.5:2000SEP083715678H1 455 729 37 LG:OOb848.5:2000SEP087679392) 1 361 464 37 LG:006848.5:2000SEP0886036344 343 732 37 LG:006848.5:2000SEP087171363H1 386 732 38 LG:198450.2:2000SEP083765347H 1 1 286 38 LG:198450.2:2000SEP082881536F6 23 509 38 LG:198450.2;2000SEP082881536H1 23 287 38 LG:198450.2:2000SEP083692305H l 226 529 _ . ~2.~__ SEQ ID Template ID Component Start Stop NO: iD

38 LG:198450,2;2000SEP082119916Th 467 1024 39 LG:1008175.1:2000SEP086798057F8 1 565 39 LG:1008175,1:2000SEP086798057H1 1 529 39 LG:1008175.1;2000SEP08679805778 490 1065 40 LG:437981,11:2000SEP087401501 H 1 569 40 LG:437981.11;2000SEP083254083H 37 260 41 LG;1025549.1;2000SEP08679b976H 1 253 41 LG:1025549,1:2000SEP086796976F8 45 582 41 LG;1025549,1;2000SEP08679697678 217 776 42 LG:327226.16:2000SEP08551971 H1 1 121 42 LG;327226.16;2000SEP083019718H1 1 281 42 LG:327226,16:2000SEP083479389H1 26 211 42 LG:32722b.16;2000SEP081696849Th 46 535 42 LG:327226.16:2000SEP0832289827b 273 546 42 LG;327226.16:2000SEP082948548H1 478 588 43 LG:I 387394,5:2000SEP086825507) 1 647 43 LG;1387394,5:2000SEP08673356H1 80 226 43 LG:1387394.5;2000SEP087b1227bJ1 151 694 43 LG;1387394,5:2000SEP086825507H1 309 818 44 LG;445188,3;2000SEP085434427H1 1 210 44 LG:445188.3:2000SEP085434427F9 T T 62 44 LG:445188,3;2000SEP087234208H1 40 323 44 LG:445188,3:2000SEP087689303)1 b7 612 44 LG;445188.3;2000SEP082588419H1 106 336 44 LG:445188,3:2000SEP082588419Fb 106 323 44 LG:445188,3:2000SEP081465708H1 21 235 44 LG:445188.3:2000SEP087234146H 39 323 44 LG;445188.3;2000SEP08233146486 20 608 44 LG:445188,3;2000SEP0823314b4H1 20 237 44 LG;445188,3:2000SEP087658611 H 15 324 44 LG:445188.3:2000SEP085802042H1 7 325 44 LG;445188,3:2000SEP0879408b3H1 1 323 45 LG;898864.11:2000SEP084179195Fb 1 506 45 LG:8988b4,11:2000SEP087734109H2 167 570 45 LG;898864.11;2000SEP08g3401261 321 750 45 LG;898864,11;2000SEP083323281 H 379 632 45 LG;898864,11:2000SEP083790088H 386 675 45 LG;898864.11;2000SEP0832 T 3979H 527 673 T

45 LG:898864,11:2000SEP084179195H1 1 267 46 LG:018739.2;2000SEP08143b493H 1163 1424 46 LG:018739.2:2000SEP08159249H 1 1444 1643 46 LG;018739.2;2000SEP08793 T T 11 1 484 46 LG:018739,2:2000SEP083522778H1 341 576 46 LG;018739.2:2000SEP0882883522 840 1191 46 LG:018739.2:2000SEP084333260F6 710 1141 46 LG;018739.2:2000SEP085203041 Fb 407 877 46 LG:OT8739,2:2000SEP08819b3365 1077 1572 46 LG:OI 8739.2:2000SEP085042285H 979 127 SEQ ID Template ID Component Start Stop NO: ID

46 LG;018739.2:2000SEP083402768H1 994 1247 46 LG:018739.2:2000SEP084344137H1 1032 1305 46 LG:018739.2:2000SEP084333260N 1 865 1141 47 LG:302915.b;2000SEP086949968H1 193 786 47 LG:302915.6:2000SEP084217462H 1 512 767 47 LG:302915.6:2000SEP084217462F6 512 832 47 LG:302915.b;2000SEP087316858Hi 107 387 47 LG:302915.6:2000SEP085044773H1 1 274 47 LG:3029i5.b:2000SEP085044773F8 1 426 48 LG;404418.3:2000SEP087607614J1 215 804 48 LG:404418.3:2000SEP086009830H 1 233 520 48 LG;404418.3:2000SEP087607614H1 1 541 48 LG:404418.3;2000SEP087714061J1 127 689 48 LG:404418.3:2000SEP085515579H 1 2b7 423 48 LG:404418.3:2000SEP087714061H1 380 923 48 LG:4044i8.3:2000SEP0883231516 446 758 49 LG:374853.2:2000SEP083559850F6 1 530 49 LG:374853.2:2000SEP083559850H1 2 304 49 LG:374853.2;2000SEP088316550 i 93 475 49 LG:374853.2;2000SEP088713154 303 392 49 LG:374853.2:2000SEP087080736H 1 437 939 49 LG:374853.2:2000SEP08694901588 515 1137 49 LG:374853.2;2000SEP086326129H1 533 789 49 LG;374853.2:2000SEP08433967H1 655 862 49 LG:374853.2;2000SEP084891603H1 1049 1144 49 LG;374853.2:2000SEP086933322Hi 1349 1856 49 LG:374853.2;2000SEP081685549Th 1403 1872 49 LG:374853.2;2000SEP083286591 H2 893 1135 49 LG:374853.2:2000SEP083284066H1 895 1140 49 LG:374853.2:2000SEP081685549F6 1024 1499 49 LG:374853.2:2000SEP081685549H 1 1024 1144 49 LG:374853.2:2000SEP081685137H1 1024 1144 50 LG:228930.1:2000SEP083802974H 1 1027 1307 50 LG:228930.1;2000SEP087626122J1 541 1178 50 LG:228930.1:2000SEP084753733H 1 121 279 50 LG:228930, i :2000SEP084753733F8 122 b 13 50 LG:228930.1:2000SEP087065882H1 183 679 50 LG:228930.1:2000SEP0885676063 251 722 50 LG:228930.1;2000SEP081576986F6 270 661 50 LG:228930.1;2000SEP081576986H 1 270 349 50 LG:228930.1:2000SEP081576986Th 275 683 50 LG;228930.1:2000SEP0883843718 364 724 50 LG:228930.1:2000SEP0883750491 408 722 50 LG:228930.1:2000SEP083604635N1 409 584 50 LG:228930.1;2000SEP087738302J1 518 1130 50 LG:228930.1:2000SEP086991066H1 1 190 51 LG:273593.b:2000SEP086772637H1 1 466 51 LG:273593.6:2000SEP083459140H 1 35 283 SEQ ID Template ID Component Start Stop NO: ID

51 LG;273593.6:2000SEP083459140F7 58 579 51 LG;273593.b:2000SEP081957812F6 413 838 51 LG:273593.6:2000SEP081957812H1 413 688 51 LG;273593.b;2000SEP081871603H1 511 636 51 LG;273593.6:2000SEP08~3939407H1 626 730 52 LG:008215.1;2000SEP08506018479 906 1498 52 LG;008215.1:2000SEP08506018478 1024 1488 52 LG:008215.1:2000SEP081263165N 1 1204 1346 52 LG;008215.1:2000SEP086357347F8 103 759 52 LG;008215.1:2000SEP086357347H 1 103 301 52 LG:008215.1:2000SEP08635734778 183 726 52 LG:008215.1:2000SEP083916841 H 415 704 52 LG:008215.1:2000SEP086860554H 1 11 290 52 LG:008215.1:2000SEP085089859H1 11 300 52 LG:008215.1;2000SEP086780977) 1 1 418 52 LG;008215.1;2000SEP086595552H2 1 448 52 LG:008215.1:2000SEP08g2112516 731 1225 52 LG:008215.1;2000SEP081319927H 1 788 1020 52 LG:008215.1;2000SEP081319927F6 788 1220 52 LG:008215.1;2000SEP085060184H1 848 1130 52 LG:008215.1;2000SEP087090761 H 445 971 52 LG;008215.1;2000SEP083916841 F8 433 954 ' 53 LG:337160.1;2000SEP08g3239640 1313 1541 53 LG:337160.1:2000SEP08g2080803 1320 1544 53 LG:337160.1:2000SEP08g4269757 1330 1534 53 LG;337160.1:2000SEP08g1421937 1280 1537 53 LG:337160.1:2000SEP083749493F6 6 343 53 LG:337160.1:2000SEP08g 1925336 11 448 53 LG;337160.1:2000SEP08g2106751 105 561 53 LG:337160.1:2000SEP083457353F6 1. 483 53 LG:337160.1:2000SEP083457353H1 1 247 53 LG:337160.1:2000SEP083749493H1 6 294 53 LG:337160.1:2000SEP08g6439253 1077 1540 53 LG;337160.1:2000SEP08g3596807 1110 1534 53 LG:3371 b0.1:2000SEP08g5526629 1109 1539 53 LG:337160.1:2000SEP08g5232677 1075 1539 53 LG;337160.1:2000SEP084402877F6 140 733 53 LG:337160.1;2000SEP084402877H1 135 389 53 LG;337160.1:2000SEP085923530H1 108 394 53 LG:337160.1;2000SEP083664104H1 440 732 53 LG:3371 b0.1;2000SEP08g 1164166 349 674 53 LG:337160.1:2000SEP085189449F8 1 b2 723 53 LG:337160.1:2000SEP08g6837258 1034 1541 53 LG:337160.1;2000SEP08g752491 609 905 53 LG;337160.1:2000SEP08g1422034 686 1027 53 LG:337160.1:2000SEP085490664H1 696 990 53 LG;337160.1:2000SEP08374949376 916 1492 53 LG:337160.1;2000SEP08518944979 973 1433 __ ___ _ SEQ ID Template ID Component Start Stop NO; ID

53 LG;337160.1;2000SEP0851673b8Hi 563 803 53 LG:337160.1;2000SEP0883593694 1073 1447 53 LG;337160.1:2000SEP088752492 1196 1539 53 LG:337160.1:2000SEP0885633598 1272 1538 53 LG:337160.1:2000SEP0884153397 1272 . 1538 53 LG:337160.1:2000SEP083457353T6 1110 1489 54 LG;3950b3.1;2000SEP0883849737 2713 2998 54 LG:395063.1:2000SEP084073057H T 2689 2978 54 LG;3950b3.1:2000SEP084073057F6 2688 2756 54 LG:395063.1:2000SEP084668484H 1 2671 2919 54 LG;395063.1:2000SEP083535582F6 2636 3182 54 LG:395063.1;2000SEP083535582H1 2636 29i 54 LG:3950b3.1;2000SEP083b9b54bTb 1915 2460 54 LG:395063.1:2000SEP083484210H1 2476 2809 54 LG;395063.i;2000SEP087093324F8 1378 1771 54 LG:395063.1:2000SEP086785022H 1 36 ~ 340 54 LG:395063. i :2000SEP083699565H 1 T 285 54 LG;395063.1;2000SEP0885054669 2128 2493 54 LG;3950b3.1:2000SEP0883181305 2249 2493 54 LG:3950b3.1:2000SEP082866136H1 2004 2248 54 LG:3950b3.1;2000SEP087093763F8 1397 1771 54 LG;395063.1:2000SEP082674222H1 1886 2108 54 LG:395063. i ;2000SEP083486280H 1 1566 1661 54 LG:395063.1:2000SEP087401964H 1 1654 2194 54 LG:3950b3.1:2000SEP086828352) 1 67 594 54 LG:3950b3. l :2000SEP084i 80711 H 54 201 54 LG:395063.1:2000SEP086788461 H 40 474 i 54 LG:3950b3.1;2000SEP087700096H i 254 855 54 LG:395063.1;2000SEP08031180H 1 206 365 54 LG;395063.1;2000SEP08030545H1 141 365 54 LG:3950b3.1:2000SEP087610103H 1 75 603 54 LG;3950b3.1:2000SEP083b9b54bFb 810 1323 54 LG:395063.1;2000SEP086828352H 1 619 i 1 b5 54 LG:395063.1:2000SEP087086817H1 402 950 54 LG:395063.1:2000SEP08~ 1426382H i 240 1511 54 LG:3950b3.1:2000SEP087093763H1 1378 1771 54 LG:395063.1:2000SEP085732526H 1 1047 1322 54 LG:3950b3.1:2000SEP083696546H 1 812 1096 54 LG:3950b3, i :2000SEP084668004H i 2426 2525 55 CG:9790b9.4:2000SEP083988928H 1 11 b8 1356 55 LG:979069.4;2000SEP08398892886 1168 1654 55 LG:9790b9.4:2000SEP084320977Hi 1238 1523 55 LG:979069.4:2000SEP083436719H 1 1300 1538 ~

55 LG:979069.4;2000SEP083988928T6 1414 1924 55 LG:979069.4:2000SEP084822576H 1 1868 2130 55 LG:979069.4:2000SEP087664878H1 925 1423 55 LG:979069.4:2000SEP088839595 1022 1258 55 LG:9790b9.4:2000SEP085390613H1 1 259 SEQ ID Template ID Component Start Stop NO; ID

55 LG:9790b9.4:2000SEP085390613F8 1 555 55 LG;9790b9.4;2000SEP087664878J1 364 998 65 LG;979069.4:2000SEP08424877986 543 993 55 LG:979069.4:2000SEP081681947H1 600 814 55 LG:9790b9.4:2000SEP08g2022820 722 1061 56 LG:346663.5:2000SEP083421067H1 127 327 56 LG;34b663.5:2000SEP085088677H 85 337 56 LG;346663.5:2000SEP08211828486 1 370 56 LG;346b63.5:2000SEP084616708H1 1b8 331 56 LG:34b663.5;2000SEP08g2241506 172 611 56 LG:346663.5;2000SEP08g2054215 202 587 56 LG:346663.5;2000SEP08g2882171 226 6l b 56 LG:346663.5;2000SEP08g6086765 236 615 56 LG:346663.5:2000SEP08g5547339 241 615 56 LG;346663.5;2000SEP08g3753350 243 615 56 LG;346b63.5:2000SEP08g2054056 253 616 56 LG:346663.5:2000SEP08g6477039 271 618 56 LG:346663.5;2000SEP08g2806480 332 612 56 LG;3466b3.5:2000SEP08053836H1 381 606 56 LG;346663.5:2000SEP08261802H1 88 258 56 LG:346663.5;2000SEP082118284H1 1 266 56 LG:346663.5;2000SEP08857738H1 54 354 56 LG:346663.5:2000SEP086844557H1 89 619 57 LG:3476i 5.1;2000SEP083532722H 1 184 57 LG:347615.1:2000SEP083532722F6 1 259 57 LG;347b15.1:2000SEP08353272276 40 560 58 LG:1397067.1:2000SEP08g6568429 39 440 58 LG: i 397067, i 7606974H i 417 :2000SEP08 i 58 LG:1397067.1:2000SEP084112486H1 547 812 58 LG:13970b7.1:2000SEP082207794F6 436 998 58 LG:1397067.1:2000SEP082207794H1 436 705 58 LG: i 3970b7.1:2000SEP082432882H 60 289 i 58 LG:13970b7.1;2000SEP084790250H 243 ' 506 58 LG:13970b7.1;2000SEP085095324H1 794 1055 58 LG:1397067.1;2000SEP087002940H1 754 961 59 LG:120675.1:2000SEP08399139386 20 532 59 LG:120675.1:2000SEP085356838H1 1 207 59 LG;120b75.1:2000SEP083191083H1 390 715 59 LG;120675.1:2000SEP08319108386 390 966 59 LG:120675.1:2000SEP083343664H 324 587 59 LG:120675. i ;2000SEP08166952H 1 111 413 59 LG;120b75.1:2000SEP086917760H1 137 619 59 LG:120675.1:2000SEP087143843H1 286 867 59 LG:120675.1:2000SEP083274716H1 571 817 59 LG:120675.1:2000SEP08g 1963587 434 837 59 LG:120b75.1:2000SEP08~ g2105985 623 1074 59 LG:120675.1:2000SEP087040182H1 623 1145 59 LG; i 20675.1:2000SEP087674849H2 605 1197 ~ . ____________ __-_ __ 127 SE6~ Template ID Component Start Stop ID NO: ID

59 LG;i20675.T:2000SEP082866547F6 1100 1490 59 LG;120675.1;2000SEP082908672H 804 1071 1~

59 LG:120b75.1:2000SEP08T 257063H 941 1 T

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61 LG:220495.3:2000SEP085099033H i 310 1579 6l LG:220495.3:2000SEP084147460H1 1316 1507 b 1 LG:220495.3:2000SEP08314260376 i 365 1823 61 LG:220495,3:2000SEP083689942H1 1402 1b79~

61 LG:220495.3:2000SEP08g4394682 1427 1869 61 LG:220495.3:2000SEP08g3418148 1429 1868 61 LG:220495.3:2000SEP08g 1398292 1439 1845 61 ~ LG:220495,3:2000SEP086197152H1 1448 1883 61 LG:220495.3:2000SEP08263096076 1458 1827 61 LG:220495.3:2000SEP08g3424422 1492 1866 b 1 LG:220495.3:2000SEP08g 1139137 836 1180 61 LG:220495.3:2000SEP082555307H1 956 1207 61 LG:220495,3:2000SEP082554584H1 956 1205 6l LG:220495.3:2000SEP08g781616 1019 1303 6l LG:220495.3:2000SEP086937534H1 1045 1646 61 LG:220495,3:2000SEP086092295H1 1104 1361 6l LG:220495.3:2000SEP08g4435582 1 380 6l LG:220495.3:2000SEP086073452H1 72 231 61 LG:220495,3:2000SEP08~7204038H1 148 663 61 LG:220495.3:2000SEP086981431H1 294 824 61 LG:220495,3:2000SEP082630960H1 730 964 61 LG:220495.3:2000SEP082b309bOFb 730 1089 61 LG:220495.3:2000SEP08609082H 1 801 1064 6l LG:220495.3:2000SEP08g564302 804 1002 61 LG:220495.3:2000SEP086572570) 1 436 61 LG:220495.3:2000SEP08744778572 1788 2239 b1 LG:220495.3:2000SEP083242659H1 1893 2113.

6l LG:220495,3:2000SEP08g823764 2038 2374 62 LG:274551.1:2000SEP08g4325750 1 103 62 LG:27455 i .1:2000SEP084290049H 1 124 62 LG:274551.1:2000SEP08' 4290049F6 1 353 62 LG:274551.1:2000SEP085493752H 172 444 63 LG:429658.27:2000SEP08g5110045 203 646 63 LG:429658,27:2000SEP08g5665175 196 645 63 LG:429658,27:2000SEP08g3700373 299 642 63 LG:429658.27:2000SEP08g300i5i4 414 640 b3 LG:429658.27:2000SEP08g3835002 361 639 b3 LG:429b58.27:2000SEP08g 1367049 263 638 63 LG:429b58.27:2000SEP08g2i 10578 472 639 63 LG:429b58.27:2000SEP08g 1367140 292 625 63 LG:429658,27:2000SEP085825096H1 202 557 63 LG:429b58.27:2000SEP0894389481 1 539 63 LG:429658,27:2000SEP085825196H1 202 521 b3 LG:429b58.27:2000SEP08g1502057 260 460 b3 LG:429658.27:2000SEP08g3118005 249 457 b3 LG:429b58.27:2000SEP08g3041363 195 457 b3 LG:429658,27:2000SEP08g3048788 190 457 b3 LG:429b58.27:2000SEP08943894H 1 1 302 _ -129 SE62 Template (D Component Start Stop ID NO: ID

b4 LG:246194.18:2000SEP086944445H 702 1175 64 LG;246194.18:2000SEP085028768H1 723 995 64 LG:246i 94.18;2000SEP08i 339502H 750 1023 i 64 LG:246194.18:2000SEP0843i7877H1 751 956 64 LG:246194,18:2000SEP081671388H1 703 782 64 LG:24b194.18:2000SEP081671264H1 703 910 64 LG:246194.18:2000SEP08502877bH1 723 991 b4 LG:246194.18:2000SEP082365229H 767 1007 64 LG:24b194.18:2000SEP08030557H1 7b8 896 64 LG:246194.18:2000SEP0803 i 790H 774 1007 64 LG;246194,18:2000SEP08031792Hi 774 1022 64 LG;246194.18;2000SEP0803194bH1 774 96b b4 LG:246194.18:2000SEP08031427H 1 774 974 64 LG:24b194.18:2000SEP08032531H1 774 1025 64 LG:246194.18:2000SEP08031b08H1 774 995 64 LG:24b194.18:2000SEP08030659H1 774 950 b4 LG;246194. i 8:2000SEP08g 1270439 780 1 i 64 LG;246194.18;2000SEP08g 1241966 798 1082 b4 LG:24b194.18:2000SEP0881990977 798 982 64 LG;246194,18:2000SEP088981948 812 1087 b4 LG:24b194.18:2000SEP084700087H1 820 1076 64 LG:246194.18:2000SEP088749487 838 904 64 LG:24b194.18:2000SEP086744795H1 840 1422 64 LG:246194.18:2000SEP088711338 888 1160 64 LG;246194.18:2000SEP08871b153 898 1195 64 LG:24b194.18:2000SEP082720633H1 931 1164 64 LG:24b194,18:2000SEP08167b222H1 969 1178 64 LG;24b194.18:2000SEP085810107H1 9b9 1253 64 LG:246194.18:2000SEP08l 675139H 9b9 1175 64 LG;246194.18:2000SEP08b1b9319H1 969 1268 b4 LG:246194.18:2000SEP088828043 1033 1288 b4 LG:24b194.18:2000SEP085818587H1 1057 1163 64 LG:246194.18:2000SEP085818729H 1057 i 375 64 LG;246194.18:2000SEP085814910H1 1057 1366 64 LG:24b194.18:2000SEP085813775H1 1057 1359 64 LG:24b194.18;2000SEP085i88360H1 584 856 64 LG:24b194.18:2000SEP0881281006 b74 1140 64 LG:246 i 94. i 8869772 695 1019 8:2000SEP08 b4 LG:246194,18:2000SEP082888196H 1 278 64 LG;24bi94.18:2000SEP08288819bF6 1 5b2 64 LG;24b194.18:2000SEP08173997bRb 2 71 b4 LG:246i94.18:2000SEP081739976H1 3 229 64 LG;246194.18:2000SEP081315b33H1 87 280 64 LG:246194.18:20005EP08079560H 1 b94 852 64 LG:24b194.18:2000SEP084321295H1 699 964 64 LG:246194.18:2000SEP084144711 H1 96 451 64 LG:24b194.18:2000SEP08554b73bH1 2i0 419 64 LG:246194, i 8:2000SEP086450480H 237 805 __ __ _____ SEQ (D Template ID Component Start Stop NO: fD

64 LG:246194.18;2000SEP084502146H1 241 513 64 LG:24b 194,18:2000SEP081945717H 1 276 513 .64 LG:246194.18:2000SEP083614166F6 363 888 64 LG:246194,18:2000SEP083614166H1 364 bbl b4 LG;24b194.18:2000SEP085350605H1 385 629 64 LG:246194.18:2000SEP084752634H1 439 694 b4 LG:246194.18:2000SEP083607954H1 445 638 64 LG:24b194.18:2000SEP085260789H1 478 715 64 LG;246194,18:2000SEP08230783886 488 955 64 LG:24bi94.18:2000SEP082307838H1 488 746 64 LG;246194,18:2000SEP08g983783 554 908 64 LG:246194,18:2000SEP087936779H 1 566 960 64 LG:24b194.18:2000SEP084855732H2 1626 1898 64 LG:246194,18:2000SEP083665761H1 1628 1918 64 LG:246194.18;2000SEP086433267H1 1627 1935 b4 LG;24b194.18;2000SEP084367924H1 1630 1888 b4 LG;24b194.18:2000SEP084368189H1 1630 1875 64 LG;24b194.18;2000SEP081732794Th 1633 2006 b4 LG:246194.18:2000SEP08g718180 1638 1988 64 LG:24b194.18:2000SEP08g5592464 1638 2045 64 LG:246194.18:2000SEP08g4189341 1647 2045 64 LG:246194.18:2000SEP084500190H1 1649 1903 64 LG;246194.18:2000SEP08g1242740 1653 2046 64 LG;24b194,18;2000SEP08g2183532 1656 2043 b4 LG;24b i 94,18:2000SEP08g51 i 0196 1657 2098 64 LG;24bi94.18;2000SEP08g2335977 1659 2046 64 LG:246194.18:2000SEP08g T 267649 1661 2046 64 LG:24b194.18:2000SEP08g5530876 167i 2045 64 LG:24b194.18:2000SEP08g6133595 1674 1935 b4 LG:246194.18:2000SEP08g5529894 1674 2045 64 LG:24b194.1~8;2000SEP08g1226406 1679 2045 b4 LG;24b194.18:2000SEP08g4452780 1683 2045 64 LG:24b194.18:2000SEP08g1024458 1688 2044 b4 LG:24b194.18:2000SEP08g4295379 1692 2045 b4 LG:24b194.18:2000SEP084001495H1 1691 1856 64 LG;246194.18:2000SEP08g982479 1729 2038 b4 LG;246194,18:2000SEP08g3245992 1725 2053 b4 LG:246194,18:2000SEP08g341 6820 1732 2045 64 LG:24b194.18:20DOSEP08g1990978 1738 2045 b4 LG:246194.18:2000SEP08g3412158 1743 2051 64 LG;246194.18:2000SEP08g1027353 1744 2013 b4 LG:24b194.18:2000SEP08g1267651 1746 2046 64 LG:246194.18:2000SEP08g5528370 1763 2045.

b4 LG:246194.18:2000SEP08g6471524 1771 2045 b4 LG:246194.18:2000SEPD81929565Th 1793 2005 64 LG:246194.18:2000SEP08g2819147~ 1799 2045 b4 LG:246194,18:2000SEP08g 1209946 1800 2046 64 LG:24b194.18;2000SEP081929565F6 1804 2043 T!\BLE 3 SEQ ID Terniplate ID Component Start Stop NO: ID

64 LG:246194.18:2000SEP08192942416 1804 2016 b4 LG:246194.18:2000SEP081929565H1 1804 2049 b4 LG:246194.18:2000SEP0883736234 1842 2046 64 LG;246194.18:2000SEP0882433089 1863 2050 b4 LG:246194.18:2000SEP0886398179 1872 2048 b4 LG:246194.18:2000SEP088718977 1881 2045 64 LG:246194.18:2000SEP088869773 1884 2055 64 LG:246194.18:2000SEP088749488 1890 2048 b4 LG:246194.18:2000SEP088734528 1908 2028 b4 LG:246194.18:2000SEP088981893 1921 2039 64 LG:246194.18:2000SEP088821354 1939 2043 b4 LG:246194.18:2000SEP0883422981 1560 1987 64 LG:246194.18:2000SEP0883597381 1590 2045 b4 LG:246194.18:2000SEP0885110713 1603 2045 b4 LG:246194.18:2000SEP085836193H1 1602 1877 b4 LG:246194.18:2000SEP088716154 1615 2037 64 LG:246194.18:2000SEP085763563H1 1612 2045 64 LG:246194.18;2000SEP0884175431 1613 2048 64 LG:246194.18:2000SEP0884327368 1615 1994 64 LG:246194.18:2000SEP08833671 b5 1618 2051 64 LG:246194.18:2000SEP0883446877 1621 2050 64 LG:246194.18:2000SEP0882879096 1622 2045 b4 LG:246194.18:2000SEP0886698474 1622 1986 64 LG:246194.18:2000SEP0839204876 1364 1942 b4 LG:246194.18:2000SEP086728329H1 1372 1979 64 LG:246194.18:2000SEP0827716286 1373 1854 64 LG:24b194.18:2000SEP0882178308 1385 1457 b4 LG:246194.18:2000SEP087242736H1 1431 1989 b4 LG:246194.18:2000SEP0883917453 1477 1935 b4 LG:246194.18:2000SEP087589751H1 1484 2021 b4 LG:246194.18:2000SEP0885886998 1487 1935 b4 LG:246194.18:2000SEP08173271376 1501 2002 b4 LG:246194.18:2000SEP084184039H1 1503 1789 64 LG:246194.18:2000SEP0884188392 1529 1987 b4 LG:246194.18:2000SEP0882189470 1550 1939 b4 LG:246194.18:2000SEP082612692H1 1556 1789 b4 LG:246194.18:2000SEP0883596759 1556 1987 b4 LG:246194.18:2000SEP084664359H1 1675 1921 64 LG:246194.18:2000SEP0882694553 1679 2045 64 LG:246194.18:2000SEP085816073H1 1057 1350 64 LG:246194.18:2000SEP085814685H1 1057 1359 64 LG:246194.18;2000SEP085813026H1 1057 1346 64 LG:246194.18:2000SEP085816684H1 1057 1349 64 LG:246194.18:2000SEP085817065H1 1057 1306 64 LG:24b194.18:2000SEP085818965H1 1057 1301 64 LG:246194.18:2000SEP085814606H1 1057 1366 64 LG:246194.18;2000SEP088718007 1063 1391 64 LG:246194.18:2000SEP085877327H1 1077 1269 SE6~ Template ID Component Start Stop ID NO: ID

b4 LG:24b194,18;2000SEP084553620H1 11 i.5 1383 64 LG:24b194.18;2000SEP085819710H1 1121 1311 64 LG:246194.18:2000SEP08g734631 1153 1269 64 LG;246194.18:2000SEP08g2185031 1168 1304 b4 LG:246194,18;2000SEP085592178H1 1180 1436 64 LG:246194.18:2000SEP081949202H1 1179 1436 b4 LG;246i94,i8;2000SEP084861510H1 1207 1476 b4 LG:246194.18:2000SEP086213288H1 1328 1480 64 LG:246194.18:2000SEP08361416676 1348 2000 65 LG:000874.1:2000SEP08417806476 i 870 2249 65 LG;000874.1:2000SEP08g2836242 1892 2253 b5 LG:000874,1:2000SEP08g4147256 1894 2282 65 LG:000874,1:2000SEP08g3678872 1895 2285 65 LG;000874.1;2000SEP084515055H 1904 2152 b5 LG:000874.1;2000SEP08676441 R6 1983 2282 65 LG:000874.1;2000SEP08676441H1 1983 2256 b5 LG:000874.1;2000SEP0867644176 1983 2241 65 LG;000874,1:2000SEP08672386H 1 1983 2241 65 LG:000874.1;2000SEP08g6043865 2104 2282 b5 LG;000874.1;2000SEP08g5663173 2145 2274 65 LG;000874.1:2000SEP084178064F6 520 1026 65 LG;000874.1:2000SEP086000160H1 968 1466 65 LG:000874.1;2000SEP086308558Hi 967 1528 65 LG:000874,1;2000SEP086558026H 1399 1961 65 LG;000874,1:2000SEP084311435H1 1417 1572 65 LG;000874,1:2000SEP086560545H 1429 1940 b5 LG:000874.1;2000SEP086445251 T8 1627 2176 65 LG;000874.1;2000SEP08346856476 i 858 2234 a.

65 LG:000874,1;2000SEP083468564H1 1865 2137 65 LG:000874.1;2000SEP083468564F6 1865 2218 65 LG;000874,1:2000SEP087073540H1 i 329 65 LG;000874.1:2000SEP087287283H1 82 396 65 LG;000874.1;2000SEP084711204H 92 226 . 1 65 LG:000874,1:2000SEP086444020H1 95 bll 65 LG;000874.1;2000SEP086445251 F8 339 900 65 LG:000874. i ;2000SEP08644525 i 339 460 65 LG;000874.1:2000SEP084178064H1 520 770 66 LG:239967.7;2000SEP084137638H1 67 340 ~

66 LG:239967,7: 1002437H1 1 226 66 LG:239967.7:2000SEP086452421 H2 4 321 66 LG:2399b7.7;2000SEP085699293H1 5 196 67 LG:238388.1;2000SEP08g4114i41 3607 3994 67 LG;238388,1;2000SEP08299608176 3611 3957 b7 LG;238388.1:2000SEP085550244H1 3628 3874 67 LG:238388.1:2000SEP084787718H1 3645 3890 67 LG;238388,1:2000SEP081712082H 3647 3849 67 LG:238388.1:2000SEP085205979H 3673 3911 67 LG:238388.1:2000SEP08865_21971 3741 3961 _ -. _ _ ___ - 1 J j .

SE6~ Template ID Component Start Stop ID NO; ID

67 LG:238388.1;2000SEP08865219H1 3740 3908 b7 LG:238388,1:2000SEP082819356H1 3749 3994 67 LG;238388,1:2000SEP08816218R1 3809 3994 67 LG:238388.1:2000SEP08816218H1 3809 3994 67 LG:238388.1:2000SEP08140689276 3811 3956 67 LG;238388.1:2000SEP081406892F6 3818 3994 67 LG:238388,1:2000SEP081406892H 1 3818 3997 67 LG:238388.1:2000SEP08g2017794 3852 3994 67 LG:238388,1:2000SEP0881621871 3856 3953 67 LG:238388.1:2000SEP08g 1210982 3872 4000 67 LG:238388.1;2000SEP08523420Ni 3936 3994 67 LG:238388,1:2000SEP0823545 l OH 3938 3994 b7 LG:238388,1:2000SEP085769009H1 749 1071 b7 LG;238388.1;2000SEP086772048H1 875 1470 67 LG:238388.1;2000SEP08g 1959595 922 1317 67 LG:238388.1:2000SEP086916395H1 1002 1294 67 LG:238388.1:2000SEP083563552H 1 1004 ~ l 310 67 LG:238388.1:2000SEP086916017H1 1005 1294 67 LG;238388,1;2000SEP087bb1482Hi 1098 1671 b7 LG:238388,1:2000SEP084777952H 1 1260 1531 67 LG:238388,1:2000SEP085431473H1 1426 1691 b7 LG:238388.1:2000SEP085431473F6 1426 1731 67 LG;238388.1;2000SEP087371680H) 1453 1844 67 LG;238388,1:2000SEP08g2825556 1497 2004 67 LG;238388,1:2000SEP08479240H 1 1549 1758 67 LG:238388,1:2000SEP08g5809860 1609 1891 67 LG;238388.1:2000SEP08543147376 1640 2165 b7 LG;238388,1;2000SEP082886276N 1 1656 1928 b7 LG:238388.1:2000SEP083788121 H 1797 2072 67 LG:238388, l :2000SEP084129226H2 1857 2111 67 LG:238388,1;2000SEP08766i 482) 1860 2408 67 LG:238388.1;2000SEP084129490H1 1858 2075 67 LG;238388.1;2000SEP085835769H1 1934 2196 67 LG;238388.1;2000SEP087677342)1 2028 2587 b7 LG;238388,1;2000SEP085727827H l 2057 2563 b7 LG:238388,1:2000SEP085975633H1 2082 2535 b7 LG;238388.1;2000SEP087006547H1 2095 2661 b7 LG;238388. l :2000SEP08g3146134 2211 2487 b7 LG:238388.1;2000SEP086757328H 1 2388 2954 b7 LG:238388.1:2000SEP087737258H1 2481 3065 b7 LG:238388.1:2000SEP082922871 H 2556 2836 l b7 LG;238388,1:2000SEP085412320H 1 2576 2857 b7 LG:238388.1:2000SEP08382 l 375H 2611 2853 b7 . LG:238388.1;2000SEP083821375F6 2612 3062 67 LG;238388.1:2000SEP084337484H 1 2617 2942 67 LG;238388. l :2000SEP08143684676 2629 2852 67 LG:238388.1:2000SEP084219215H 1 2689 2971 b7 LG:238388.1:2000SEP087757483) 1 1 659 _ _ _, -134 _ SEQ ID Template ID Component Start Stop NO: ID

b7 LG:238388,1:2000SEP08g654095 320 576 b7 LG:238388.1:2000SEP087364320H 1 322 678 67 LG:238388,1:2000SEP086818455H 1 361 915 67 LG:238388.1:2000SEP08g6705027 398 887 67 LG:238388.1:2000SEP087757483H1 465 1078 67 LG:238388.1:2000SEP08g654019 668 1002 67 LG:238388.1:2000SEP083769421 H 675 954 67 LG:238388, i :2000SEP087345125H 1 2765 3298 b7 LG:238388.1:2000SEP087748144H1 2765 2975 b7 LG:238388, Z :2000SEP081263237H 1 2807 2976 b7 LG:238388,1:2000SEP087614563H 1 2812 3403 67 LG:238388.1:2000SEP083813395H 1 2812 3071 b7 LG:238388.1:2000SEP086757328) 1 2838 3432 67 LG:238388.1:2000SEP08g2000982 2844 3161 67 LG:238388,1:2000SEP087120315H 1 2846 3275 67 LG:238388.1:2000SEP085798452H1 2693 3156 b7 LG:238388. i :2000SEP08g2505206 2728 2979 67. LG:238388.1:2000SEP08250263676 2895 2976 67 LG:238388.1:2000SEP085561 SbbH 2895 3042 67 LG:238388,1:2000SEP085561335H 1 2900 3144 67 LG:238388.1:2000SEP083775391 H 2904 3188 67 LG:238388.1:2000SEP08g2008372 2970 3240 b7 LG:238388.1:2000SEP082996036H 1 3002 3188 67 LG:238388.1:2000SEP082996081 H 3002 3195 i 67 LG:238388.1:2000SEP082996081 F6 3002 3347 67 LG:238388,1:2000SEP085743469H1 3002 3276 67 LG:238388.1:2000SEP083559545H1 3002 3199 b7 LG:238388,1:2000SEP081213203H1 3021 3275 67 LG:238388.1:2000SEP083901271H1 3070 3340 67 LG:238388,1:2000SEP081481976H 1 3070 3260 67 LG:238388. i :2000SEP081481976F6 3070 3514 67 LG:238388.1:2000SEP085836014H 1 3085 3359 67 LG:238388,1:2000SEP083449721 H 3117 3359 i 67 LG:238388.1:2000SEP083271276H1 3122 3364 b7 LG:238388.1:2000SEP08Ob0887H i 3153 3371 67' LG:238388,1:2000SEP086515184H1 3158 3704 b7 LG:238388.1;2000SEP082020109F6 3241 3680 67 LG:238388,1:2000SEP082020109H 1 3241 3476 67 LG:238388.1:2000SEP082783585H2 3276 3553 67 LG:238388, i :2000SEP08612351 OH 3306 37 i 67 LG:238388.1:2000SEP085817552H 1 3322 3606 67 LG:238388,1:2000SEP085822881 H 3322 3591 67 LG:238388.1:2000SEP083526793H1 3322 3528 b7 LG:238388.1:2000SEP081415243H1 3327 3586 b7 LG:238388.1:2000SEP087329748H1 3343 3949 67 LG:238388.1:2000SEP08009867H1 3346 3668 67 LG:238388.1:2000SEP081808041 H 3351 3612 67 LG:238388.1:2000SEP081808041 Fb 335i 3753 ____.__ ~

_ SEQ ID Template ID Component Start Stop NO: ID

67 LG:238388.1:2000SEP082878474H 3358 3638 67 LG:238388.1;2000SEP083794206H1 3412 3709 67 LG:238388.1:2000SEP082285 i 58H 3418 3580 67 LG;238388.1;2000SEP08304i557H1 3441 3722 67 LG:238388.1;2000SEP082133969H 3456 3710 67 LG:238388.1:2000SEP08382137576 3471 3958 67 LG:238388.1:2000SEP08202010976 3484 3952 67 LG;238388.1;2000SEP085139405H 3487 3752 67 LG:238388.1:20005EP08886271 Hl 3488 3788 b7 LG:238388.1:2000SEP081969228Hi 3496 3771 67 LG:238388.1;2000SEP08196922886 3496 3962 67 LG:238388.1:2000SEP08196922876 3496 3941 67 LG:238388.1:2000SEP084207304H1 3528 3747 67 LG:238388.1;2000SEP08g5i 10635 3531 3995 67 LG:238388.1:2000SEP08g665b8i9 3533 3994 b7 LG:238388.1:2000SEP084200482H 3534 3837 67 LG:238388,1:2000SEP08g3889867 3566 3984 67 LG:238388.1:2000SEP08180804176 3565 3962 67 LG:238388.1:2000SEP08g4850515 3579 3994 67 LG;238388.1:2000SEP08148197676 3593 3932 68 LG:233674,4;2000SEP08g3048238 2946 3414 68 LG:233674.4:2000SEP08g2820354 2909 3415 b8 LG:233674.4;2000SEP08195492476 2910 3380 b8 LG:233674.4:2000SEP087335679H1 2918 3430 68 LG:233674.4:2000SEP08626535H1 2922 3164 68 LG:233b74,4:2000SEP0862653586 2922 3413 68 LG:233674.4:2000SEP086599347H1 2932 3414 68 LG:233674,4;2000SEP08g5593063 2933 3420 68 LG;233674,4:2000SEP08347940H1 2932 3059 68 LG:233674.4;2000SEP08g666613 2948 3412 68 LG:233674.4:2000SEP08g6702571 2942 3414 b8 LG:233b74,4:2000SEP086343858H1 2943 3214 68 LG;233674.4:2000SEP086316286H1 2943 3121 68 LG:233674.4:2000SEP082598676H1 1647 1909 68 LG:233674.4;2000SEP082598676F6 1647 2146 68 LG;233b74.4:2000SEP087711995) 1667 2262 68 LG:233b74.4:2000SEP08g564225 1730 1960 68 LG:233b74.4:2000SEP084346248N 1731 2018 68 LG:233674,4:2000SEP08666846H 1 1757 2030 68 LG:233674,4:2000SEP082749327H1 1769 2023 b8 LG:233b74,4:2000SEP086798844H1 1889 2448 68 LG:233674.4:2000SEP08469885H 1 1890 2050 68 LG:233674.4:2000SEP08g5837868 2954 3425 68 LG:233674.4:2000SEP08g6986716 2960 3414 68 LG:233b74,4:2000SEP08g4311811 2960 3414 68 LG;233674.4;2000SEP08g5177329 2961 3392 68 LG:233674.4:20005EP08g6661879 2962 3418 68 LG:233b74,4;2000SEP085329124H1 2696 2943 _______ X36__ SEQ ID Template ID Component Start Stop NO; ID

68 LG:233b74.4:2000SEP08g866548 2708 3015 b8 LG:233674.4:2000SEP082935b30Hi 2708 2976 68 LG;233674.4;2000SEP08g855143 2708 2983 68 LG:233674.4:2000SEP083854205H1 2725 3021 68 LG:233b74.4;2000SEP082755008H1 2727 2906 68 LG:233b74.4:2000SEP082232604H1 2729 2884 68 LG;233674.4:2000SEP08g1200259 2735 3017 68 LG:233674.4:2000SEP083970611H1 2740 2998 68 LG;233674.4:2000SEP083967950H1 2753 3000 68 LG;233b74.4:2000SEP084542927H1 2757 3019 68 LG;233674.4;2000SEP083967941 H1 2762 3000 68 LG:233674.4;2000SEP08527407079 2781 3319 68 LG;233674.4;2000SEP082831b82Hi 2818 3077 68 LG:233b74.4:2000SEP08211860476 2837 3385 68 LG:233674.4:2000SEP08g667071 2841 3729 68 LG:233674.4;2000SEP084379465H1 2855 3133 68 LG;233b74.4:2000SEP08642755F1 2882 3418 68 LG;233674.4;2000SEP085703055F6 463 677 68 LG:233b74.4;2000SEP086806348F8 472 1133 68 LG;233674.4:2000SEP08642752H1 83 301 68 LG:233b74.4:2000SEP086920944H 1 110 500 68 LG;233b74.4:2000SEP085379362H i 452 714 68 LG;233b74.4:2000SEP085703055H1 463 592 68 LG:233674.4:2000SEP086806348H 1 472 986 68 LG;233674.4:2000SEP084969531H1 495 699 68 LG;233b74.4:2000SEP085972826H1 550 1068 b8 LG;233674.4;2000SEP08g1976170 551 936 68 LG;233b74.4;2000SEP085972826F8 553 1140 68 LG:233b74.4;2000SEP086829707J1 578 1096 68 LG:233674.4:2000SEP08g2254998 3146 3414 b8 LG:233674.4;2000SEP08g21130i6 3158 3414 68 LG:233b74.4:2000SEP08g4326422 3163 3415 68 LG;233b74.4:2000SEP08g4086677 31 b5 3415 b8 LG:233b74.4;2000SEP0862653576 3135 3375 68 LG:233b74.4:2000SEP08g 1940748 3135 3414 68 LG;233b74.4:2000SEP083154259H1 3146 3410 68 LG;233b74.4:2000SEP08550108Hi 3117 3374 68 LG:233674.4:2000SEP086569734H 1 3118 3663 68 LG;233674.4:2000SEP08334525H1 3123 3358 68 LG:233674.4;2000SEP08637277iH1 3132 3405 68 LG;233674.4:2000SEP08g2058783 3135 3404 68 LG:233b74.4:2000SEP084858527H1 2690 2894 b8 LG:233674.4:2000SEP08548931 OH 2696 2980 68 LG:233674.4:2000SEP08g2154333 2681 3090 68 LG:233674.4:2000SEP086325343H 1 2648 2877 68 LG:233674.4:2000SEP081383313H 1 2682 2936 68 LG;233674.4;2000SEP086356947H1 2584 2794 68 LG:233674.4:2000SEP081954924H 1 2486 2708 SEQ ID Template ID Component Start Stop NO: ID

b8 LG:233b74.4:2000SEP086724634H 1 2499 3021 68 LG:233b74.4:2000SEP086309069H 1 2547 3125 68 LG:233b74.4:2000SEP08g 1887548 2564 2919 b8 LG:233674,4:2000SEP081726341 H1 2561 2774 68 LG:233b74.4:2000SEP081726341 Fb 2561 3091 b8 LG:233b74.4:2000SEP081727741H1 2561 2774 68 LG:233b74,4:2000SEP081727741 F6 2561 2979 68 LG:233674.4:2000SEP086155590H 1 2575 2876 68 LG:233b74.4:2000SEP08968911 H 1 3181 3412 b8 LG:233674.4:2000SEP0882904859 3185 3418 68 LG:233674,4:2000SEP0884568372 3203 3413 68 LG:233674.4:2000SEP082743761 T6 3212 3354 68 LG:233674.4:2000SEP0882718646 3274 3436 68 LG:233b74.4:2000SEP0882141561 3279 3410 68 LG:233674.4:2000SEP085b03bbbH1 2466 2723 68 LG:233674.4:2000SEP081954924F6 2486 2808 68 LG:233b74,4:2000SEP084851872H1 2486 2666 b8 LG:233674.4:2000SEP082933230H2 2387 2652 b8 LG:233b74,4:2000SEP084635863H1 2407 2668 b8 LG:233674.4:2000SEP08217483H1 2421 2595 b8 LG:233674,4:2000SEP08218920H1 2421 2650 68 LG:233674.4:2000SEP085395195H 1 2428 2633 b8 LG:233674.4:2000SEP085275658H 1 2432 2628 68 LG:233b74.4:2000SEP084876783H 1 2447 2726 68 LG:233b74.4:2000SEP08031485H1 2453 2625 b8 . LG:233b74,4:20005EP085611850H1 2461 2670 b8 LG:233674.4:2000SEP08i43418H1 2463 2687 b8 LG:233b74,4:2000SEP082201263H1 3092 3352 b8 LG:233674.4:2000SEP0885769561 3093 3429 68 LG:233b74.4:2000SEP0886698727 3091 3414 68 LG:233674.4:2000SEP088866438 3096 3414 68 LG:233b74,4:2000SEP086383782H 1 3100 3359 b8 LG:233674.4:2000SEP0883240885 3101 3422 68 LG:233674,4:2000SEP088855630 3104 3388 68 LG:233b74.4:2000SEP0885446385 3110 3414 68 LG:233b74.4:2000SEP08g 1148830 3111 3418 68 LG:233674,4:2000SEP0882191 69b 3112 3413 68 LG:233b74.4:2000SEP0882874136 3115 3413 68 LG:233b74,4:2000SEP088560291 3i66 3414 b8 LG:233674.4:2000SEP0882053192 31 b9 3418 68 LG:233674.4:2000SEP081322413H1 2212 2449 68 LG:233b74.4:2000SEP082743761H7 2219 2489 b8 LG:233674.4:2000SEP082743761 F6 22 i 9 2764 68 LG:233b74.4:2000SEP085087795H1 2223 2488 68 LG:233b74.4:2000SEP087764777H1 2242 2717 68 LG:233674.4:2000SEP085616170H1 2334 2630 b8 LG:233b74.4:2000SEP085662688H1 2368 2567 68 LG:233674.4:2000SEP083643051 H 2372 2647 ~~s-.

SEQ ID Template iD Component Start Stop NO ID

68 LG:233b74.4:2000SEP0820801 68H 3738 4027 68 LG;233674.4:2000SEP084570665H1 3828 4045 68 LG;233b74.4:2000SEP0884568213 2965 3415 68 LG:233b74.4:20DOSEP0884888371 2968 3419 b8 LG:233674.4;2000SEP083285729Th 2969 3375 68 LG:233674.4:2000SEP0884991299 2970 3406 68 LG:233674.4;2000SEP0885848020 2971 34i 68 LG:233b74.4:2000SEP0883751226 2972 3416 68 LG;233b74.4:2000SEP086307793H 1 2975 3410 b8 LG:233674.4:2000SEP0885362584 2975 3396 68 LG;233674.4:2000SEP0883425044 2976 3421 b8 LG;233674.4;2000SEP085043094H1 2979 3228 68 LG:233674.4:2000SEP0886835931 2980 3418 b8 LG:233b74.4:2000SEP0886663640 2984 3387 68 LG:233674.4:2000SEP08g 1939538 2985 34 i b8 LG;233674.4;2000SEP0882840778 2986 3422 68 LG:233674.4;2000SEP0885236328 2991 3414 68 LG:233b74.4:2000SEP0886199120 2997 3414 68 LG:233674.4;2000SEP0885850520 3001 3414 68 LG:233b74.4:2000SEP0883753765 3002 3414 68 LG:233b74.4:2000SEP08. 539519571 3006 3375 68 LG;233b74.4;2000SEP0884691044 3008 3414 68 LG:233b74.4:2000SEP0884649596 3013 3414 68 LG:233b74.4:2000SEP0886399696 3016 3414 68 LG:233b74.4:2000SEP0885394138 301 b 3414 68 LG:233674.4;2000SEP0886402223 3017 3414 68 LG:233b74.4:2000SEP0883245051 3026 3417 68 LG;233674.4:2000SEP086543018H1 3041 3410 b8 LG:233674.4;2000SEP08192736676 3047 3375 68 LG:233b74.4:2000SEP0885765795 3050 3418 68 LG;233674.4;2000SEP0886035660 3049 3418 68 LG:233b74.4:2000SEP084821838H 1 3050 3336 b8 LG:233674.4:2000SEP082835893F6 3052 3461 68 LG:233674.4:2000SEP082835893H1 3052 3313 68 LG;233674.4:2000SEP0886038394 3057 3426 68 LG:233674.4:2000SEP088290021 b 3055 3413 68 LG:233674.4;2000SEP0882768204 3066 3413 68 LG;233674.4;2000SEP081361188F6 3068 3414 68 LG:233b74.4:2000SEP081361072F1 3068 3414 b8 LG:233674.4:2000SEP081361188H 1 3068 3357 b8 LG:233b74.4:2000SEP08136118876 3075 3371 68 LG:233b74.4:2000SEP0882265459 3086 3418 b8 LG:233674.4:2000SEP0883308781 3086 3391 b8 LG:233674.4;2000SEP088880802 3614 3964 b8 LG:233674.4;2000SEP088831073 3616 3965 b8 LG:233674.4:2000SEP088770919 3626 3964 b8 LG:233674.4:2000SEP088874722 3647 3964 68 . LG:233b74.4:2000SEP0884850701 3287 3406 SEQ ID Template ID Component Stark Stop NO; ID

68 LG:233674.4:2000SEP08g4734601 3289 3406 b8 LG;233674.4:2000SEP084545520H1 3295 3407 68 LG:233b74.4:2000SEP08g2788765 3300 3418 68 LG;233674.4:2000SEP08g1887492 3304 3404 68 LG:233b74.4:2000SEP083349435Hi 3329 3406 68 LG;233b74.4;2000SEP08g6836622 3410 3869 68 LG:233674.4;2000SEP08g4990931 3412 3786 68 LG:233674.4;2000SEP08g315i 731 3412 3801 68 LG:233674.4:2000SEP082735154H 1 3595 3844 68 LG;233674.4;2000SEP082673809H1 3957 4045 68 LG:233674.4:2000SEP082673828H1 3963 4045 68 LG:233674.4:2000SEP086881871H1 3978 4045 68 LG;233674.4;2000SEP084772282F7 1908 2513 68 LG:233674.4:2000SEP084772282H1 1908 2165 68 LG:233674.4:2000SEP084982350H1 1971 2242 68 LG:233b74.4;2000SEP083073533H1 1979 2244 b8 LG:233b74.4:2000SEP087057649N1 2082 2531 68 LG:233b74.4;2000SEP086798844)1 2084 2726 68 LG;233b74.4:2000SEP08g2191282 2108 2416 68 LG;233674.4:2000SEP087239623H1 2203 2496 68 LG:233674.4;2000SEP083285729H1 1309 1566 b8 LG;233b74.4:2000SEP083285729F6 1309 i 891 68 LG:233674.4:2000SEP083599653H 1 1353 1652 ~

68 LG;233674.4:2000SEP085617347H1 1437 1651 68 LG:233b74.4:2000SEP08~ i 893894H 1418 1651 68 LG;233674.4;2000SEP085800444H1 711 1191 b8 LG:233b74.4:2000SEP084051463H 1 1432 1607 b8 LG:233674.4:2000SEP085274070F9 1443 2084 68 LG:233b74.4:2000SEP087711995H1 984 1604 68 LG:233674.4:2000SEP087744971 J 992 1543 68 LG;233b74.4;2000SEP081483611Hi 1106 1351 68 LG:233674.4:2000SEP086197176H1 1302 1815 68 LG;233674.4;2000SEP085274070H1 1443 1685 b8 LG:233b74.4:2000SEP085274070F8 1443 1989 68 LG;233b74.4;2000SEP084051463F8 1444 2021 68 LG:233674.4;2000SEP086534830H1 1525 2050 b8 LG;233674.4:2000SEP087764777)1 1570 2170 68 LG:233674.4;2000SEP086806348)1 1553 2175 68 LG;233674.4:2000SEP087218885H1 1628 2143 68 LG:233674.4:2000SEP086757432F8 1 345 68 LG;233b74.4;2000SEP086757432H1 18 570 68 LG:233674.4:2000SEP083486566H1 49 267 68 LG:233674.4:2000SEP0864275581 83 642 69 LG;411327.2:2000SEP085608336H1 1160 1409 69 LG;411327.2;2000SEP085608336F6 1160 1676 69 LG;411327.2:2000SEP083521640H 1 1285 1457 69 LG:411327.2:2000SEP08352164086 1303 1469 69 LG:411327.2:2000SEP086841761H1 1402 1855 40 -__ SEQ ID Template ID Component Start Stop NO: ID

69 LG:411327.2:2000SEP082417869H 1 1505 1727 69 LG:411327,2:2000SEP082417869F6 1505 1772 69 LG:411327,2:2000SEP086758624)1 1540 2134 69 LG:411327.2:2000SEP081342359F6 1580 2113 69 LG:411327.2:2000SEP087 342359H 1580 1800 69 LG:411327,2:2000SEP08g5848294 1651 2110 b9 LG:411327.2:2000SEP08g864162 1772 2090 69 LG:411327,2:2000SEP08g795684 1834 2099 69 LG:411327.2:2000SEP08g3134525 1842 2142 69 LG:411327.2:2000SEP082829095H 1 415 664 b9 LG:411327.2:2000SEP08800329H i 440 686 69 LG:41i327,2:2000SEP08224003iH1 447 699 69 LG:411327,2:2000SEP087462852H1 470 769 69 LG:411327,2:2000SEP087453938H1 606 1167 69 LG:411327,2:2000SEP087529 T 5H 617 894 69 LG:411327,2:2000SEP085083742H1 700 924 69 LG:411327.2:2000SEP086758624H 1 815 1390 69 LG:411327,2:2000SEP08300057iH1 1021 1312 b9 LG:411327,2:2000SEP087115241 H1 1136 1685 69 LG:411327.2:2000SEP083336908H1 73 304 b9 LG:411327.2:2000SEP0864260886 110 368 69 LG:411327,2:20005EP08642608H1 110 360 69 LG:411327,2:2000SEP08' 7763655H1 120 746 69 LG:411327,2:2000SEP08803330H1 400 642 b9 LG:411327,2:2000SEP086805668) i i 581 69 LG:411327.2:2000SEP08g1928792 1 296 b9 LG:411327,2:2000SEP083760715H 1 65 384 69- LG:411327,2:2000SEP082106453H1 53 344 b9 LG:411327.2:2000SEP08g1481768 66 374 69 LG:417 327.2:2000SEP08210645386 54 475 69 LG:411327.2:2000SEP08g1163559 61 449 69 ' LG:411327.2:2000SEP083473472H1 66 397 70 LG:1327310.1:2000SEP086795864H 1 1 240 70 LG:13273 i 0,1:2000SEP086795864F8 1 589 70 LG:1327310,1:2000SEP086791830H 1 2 403 70 LG:1327310,1:2000SEP08679586478 74 563 71 LG:242019,13:2000SEP084651672H 1 1 244 71 LG:242019.13:2000SEP087713679)2 24 634 72 LG:012432. i 2:2000SEP082227848 i 558 86 i 72 LG:012432.12:2000SEP08223917H1 558 733 72 LG:012432. i 2:2000SEP0822391786 558 863 72 LG:012432.12:2000SEP08g2620512 582 893 72 LG:012432,12:2000SEP087640335H2 182 783 72 LG:OI 2432,12:2000SEP083271885H 1 i 233 72 LG:OI 2432.12:2000SEP085638620H 1 1 184 72 LG:012432.12:2000SEP08g2 i 11772 1 436 72 LG:012432.12:2000SEP087640335)2 439 847 72 LG:012432, i 2:2000SEP085536760H 1 9 267 SEQ ID Template ID Component Starf Stop NO; ID

72 LG;012432.12:2000SEP081484585F6 11 506 72 LG;012432.12:2000SEP081484585H1 11 277 72 LG;012432.12;2000SEP085957017H1 128 642 72 LG:012432.12:2000SEP08222784H1 558 739 73 LG;257088.9;2000SEP08g5542884 1351 1518 73 LG:257088.9:2000SEP08g2840861 1039 1520 73 LG;257088.9:2000SEP082657966Th 567 1061 73 LG;257088.9:2000SEP0881069716 680 1035 73 LG:257088.9;2000SEP084580838H1 772 985 73 LG;257088.9;2000SEP085526482H1 717 964 73 LG;257088.9:2000SEP081705927H1 677 898 73 LG;257088.9:2000SEP0883070773 546 837 73 LG;257088.9;2000SEP082657966H1 531 742 73 LG;257088.9:2000SEP086267885H1 181 688 73 LG;257088.9:2000SEP08bi34084H1 754 964 73 LG:257088.9;2000SEP0883177730 1071 1514 73 LG;257088.9:2000SEP0882782497 1077 1441 73 LG;257088.9:2000SEP0885395430 1052 1432 73 LG;257088.9:2000SEP0881295210 786 1223 73 LG;257088.9;2000SEP086336121H1 563 1076 73 LG;257088.9:2000SEP0885768628 1043 1409 ~

73 LG:257088.9;2000SEP088576705i 1008 1388 73 LG:257088.9;2000SEP0885638685 1008 1284 73 LG;257088.9:2000SEP0877b3642Ji 628 1260 73 LG:257088.9;2000SEP087375784H1 1 270 73 LG;257088.9;2000SEP082657966F6 531 1025 73 LG;257088.9;2000SEP086354333H1 677 1001 ' 73 LG:257088.9:2000SEP086317132H1 677 956 73 LG;257088.9;2000SEP0883094268 1093 1518 74 LG;997505.5;2000SEP081317853H1 1320 1483 74 LG;997505.5;2000SEP085853247H1 1291 1560 74 LG:997505.5:2000SEP084998506H 1 1 173 74 LG:997505.5;2000SEP084998506F9 1 550 74 LG;997505.5;2000SEP084998506F8 24 521 74 LG;997505.5:2000SEP085528150H 1 488 767 74 LG;997505.5;2000SEP083400869H1 723 974 74 LG;997505.5:2000SEP084740562H2 828 1094 74 LG:997505.5;2000SEP086778477J1 899 1521 74 LG:997505.5:2000SEP088878200 1067 1329 74 LG;997505.5;2000SEP088888053 1070 1382 74 LG:997505.5:2000SEP081391708H i 1153 i 370 74 LG;997505.5;2000SEP084534154F8 1175 1701 74 LG:997505.5:2000SEP08453431 OH 1 i 76 i 421 74 LG:997505.5:2000SEP084534310F8 1175 1682 74 LG;997505.5:2000SEP084534154H1 1175 1429 74 LG:997505.5;2000SEP085853215H1 1291 1561 75 LG;481436.2;2000SEP083324046H1 274 573 75 LG:481436.2:2000SEP083635943H 1 16 3 i SEQ ID Template ID Component Start Stop NO: ID

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85 LG:1400108.1;2000SEP087040568H 306 711 85 LG:1400108.1;2000SEP084456536H 587 788 85 LG:1400108.1:2000SEP084303918H1 299 475 86 LG:254531.1:2000SEP08211674586 1 429 86 LG;254531.1;2000SEP08421393776 179 561 86 LG;254531.1:2000SEP08398352476 288 650 86 LG:254531.1;2000SEP08g5513295 318 743 86 LG:254531.1;2000SEP082116745H 1 238 86 LG;254531.1;2000SEP084771743H1 613 753 86 LG;254531.1:2000SEP08477174376 833 899 86 LG:254531.1;2000SEP084771743F6 613 894 86 LG;254531.1;2000SEP08g5678401 420 739 86 LG;254531.1:2000SEP08g4082588 420 740 86 LG;254531.1:2000SEP08g4148835 409 ' 739 86 LG;254531.1:2000SEP08g5369564 327 752 87 LG;1101317.1:2000SEP084111645H1 2107 2376 87 LG:1101317.1:2000SEP081719261H1 2130 2340 87 LG;1101317.1:2000SEP08217174H1 2135 2326 87 LG:1101317.1;2000SEP08234490876 2149 2693 87 LG;1101317.1:2000SEP087356032H1 2156 2648 87 LG:1101317.1:2000SEP081861240H1 1990 2250 87 LG:1101317.1:2000SEP083094796H1 2026 2320 87 LG:1101317.1;2000SEP087216644H1 2079 2650 87 LG:1101317.1:2000SEP08g1961970 2087 2358 87 LG;1101317.1:2000SEP085888913H1 2089 2335 87 LG:1101317.1:2000SEP085884544H1 2089 2350 87 LG:1101317.1;2000SEP08802026H 1 2092 2315 87 LG:1101317.1:2000SEP087243661H1 2103 2462 87 LG;1101317.1:2000SEP08g6402048 481 941 87 LG:1101317.1:2000SEP08'g2064228 489 942 87 LG;1101317.1;2000SEP087401413H 568 1059 87 LG:1101317.1:2000SEP087114194H2 712 1212 87 LG:1101317.1;2000SEP0814346176 738 1212 87 LG;1101317.1:2000SEP084763709H 754 1022 87 LG:1101317.1;2000SEP08223371 R1 1820 2310 87 LG:1101317.1;2000SEP081861240F6 1990 2391 87 LG;1101317.1;2000SEP08229654H 1 1820 2032 87 LG:1101317.1:2000SEP08223371 H 1820 2049 87 LG:1101317.1;2000SEP085604126H1 1845 2063 87 LG;1101317.1;2000SEP081598553H1 1851 2059 87 LG:1101317.1:2000SEP083387636H1 1865 1980 87 LG:1101317.1:2000SEP08907585H1 1866 2020 87 LG:1101317.1:2000SEP0890758582 1866 2433 87 LG:1101317.1:2000SEP086874748H1 1915 2386 87 LG:1101317.1:2000SEP08g1955731 1921 2228 87 LG:1101317.1;2000SEP083696080H1 1977 2259 87 LG:1101317.1:2000SEP08g 1963935 1 474 87 LG;1101317,1:2000SEP086817012H 1 ' 361 _ _ ___ 1 _-_ SEQ ID Template ID Component Start Stop NO: ID

87 LG:1101317.1:2000SEP086823629H1 34 600 87 LG:1101317.1:2000SEP086812964J1 38 681 87 LG:11 O 1317.1:2000SEP086812964H 138 666 87 LG:11 O 1317,1:2000SEP086535644H 234 797 87 LG:1101317,1:2000SEP08143461 H 321 756 87 LG:1101317.1:2000SEP08143461 R6 321 745 87 LG:1101317.1:2000SEP086310047H1 1461 1989 87 LG:1101317.1:2000SEP086823629J1 1486 1952 87 LG:1101317.1:2000SEP082439960H1 1494 ' 1692 87 LG:1101317.1:2000SEP081956487H1 1503 1759 87 LG:1101317.1:2000SEP081452925H1 1724 1986 87 LG:1101317.1:2000SEP081452925F1 1724 2203 87 LG:1101317.1:2000SEP083522982H1 1728 1956 ~

87 LG:1101317.1:2000SEP08g2110490 1734 2149 87 LG:1101317.1:2000SEP08g 126,6352 1743 2126 87 LG:1101317.1:2000SEP086535272H1 1742 2239 87 LG:1101317.1:2000SEP084510157H1 1749 2005 87 LG:1101317,1:2000SEP082915753H1 1761 1960 87 LG:1101317,1:2000SEP084571543H1 1778 2020 87 LG:1101317.1:2000SEP085054191 H 1795 2065 87 LG:1101317.1:2000SEP087609456J1 1539 2035 87 LG:1101317.1:2000SEP086578896H1 1566 2057 87 LG:1101317.1:2000SEP086332835H1 1566 1733 87 LG:1101317.1:2000SEP086578895H1 1571 1938 87 LG:1101317,1:2000SEP086817012J1 1583 2180 87 LG:1101317,1:2000SEP08g2016947 1597 1932 87 LG:1101317.1:2000SEP083785356H1 1654 1946 87 LG:1101317.1:2000SEP086335980H1 1660 2239 87 LG:1101317,1:2000SEP082354693F6 1660 2193 87 LG:1101317.1:2000SEP082354693H1 1660 1884 87 LG:1101317.1:2000SEP081877179H1 1695 1968 87 LG:1101317.1:2000SEP081877179F6 1695 1984 87 LG:1101317,1:2000SEP081620310H1 1697 1938 87 LG:1101317,1:2000SEP08g2059298 2344 2734 87 LG:1101317.1:2000SEP08g3434517 2343 2731 87 LG:1101317.1:2000SEP08g3753098 2346 2731 87 LG:1101317.1:2000SEP08344433H1 2346 2574 87 LG:1101317,1:2000SEP081877179Th 2346 2688 87 LG:1101317.1:2000SEP085512710H1 2351 2570 87 ~ LG:1101317.1:2000SEP08g3701288 2376 2737 87 LG:1101317.1:2000SEP08g2583867 2378 2732 87 LG:1101317.1:2000SEP082607706H1 2379 2639 87 LG:1101317.1:2000SEP08g3741708 2381 2733 87 LG:1101317.1:2000SEP08g3229991 2384 2731 87 LG:1101317,1:2000SEP08g5036157 2390 2726 87 LG:1101317.1:2000SEP085055888H1 2399 2671 87 LG:1101317.1:2000SEP082354693T6 2415 2690 87 LG:1101317.1:2000SEP08g4296980 2419 2727 SEQ ID Template ID Component Start Stop NO: ID

87 LG:1101317.1:2000SEP085297009H1 2447 2718 87 LG:1101317.1:2000SEP085296909H1 2447 2654 87 LG;1101317.1:2000SEP08643900H 1 2475 2718 87 LG:1101317.1:2000SEP0864390086 2475 2731 87 LG:1101317.1;2000SEP0864390076 2475 2693 87 LG:1101317.1:2000SEP08g6640298 2487 2731 87 LG;1101317.1;2000SEP082318777H1 2625 2722 87 LG;1101317.1:2000SEP087074835H1 2633 3063 87 LG:1101317.1:2000SEP08g3148127 2640 2734 87 LG;1101317.1:2000SEP08g2984877 2643 2739 87 LG:1101317.1;2000SEP08g712170 2650 2735 87 LG:1101317.1:2000SEP08g2909104 2663 2741 87 LG;1101317.1;2000SEP082955382H1 2671 2802 87 LG;1101317.1:2000SEP08g 1225713 2310 2730 87 LG:1101317.1:2000SEP08g3203907 2321 2737 87 LG:1101317.1:2000SEP086439019H1 2337 2682 87 LG:1101317.1;2000SEP08g3239341 2298 2732 87 LG;1101317.1;2000SEP08g2675052 2340 2738 87 LG:1101317.1:2000SEP08g4153003 2340 2731 87 LG;1101317.1:2000SEP082945971H1 2182 2482 87 LG;1101317.1;2000SEP082944561H1 2183 2485 87 LG:1101317.1;2000SEP083016776H1 2183 2482 87 LG:1101317.1:2000SEP086191566H1 2194 2502 87 LG;1101317.1;2000SEP086209904H1 2196 2501 87 LG:1101317.1:2000SEP084908028H1 2176 2419 87 LG:1101317.1:2000SEP086190886H1 2201 2376 87 LG:1101317.1:2000SEP08186124076 2252 2707 87 LG;1101317.1;2000SEP08223371 Fl 2252 2731 87 LG:11 O 1317.1;2000SEP08683952H 1 2285 2484 87 LG;1101317.1:2000SEP08164305176 2285 2684 87 LG:1101317.1;2000SEP08g4243434 2286 2734 87 LG:1101317.1:2000SEP083860584H1 2291 2524 87 LG:1101317.1:2000SEP084337054H1 2297 2549 87 LG:1101317.1;2000SEP087439030H1 1225 1748 87 LG;1101317.1:2000SEP081313614H1 1234 1402 87 LG:1101317.1:2000SEP085633301H1 1255 1413 87 LG:1101317.1:2000SEP087932553H1 1296 1903 87 LG:1101317.1:2000SEP086864228H1 1333 1854 87 LG:1101317.1:2000SEP087171990H1 1346 1904 87 LG:1101317.1;2000SEP086316428H1 1362 1642 87 LG:1101317.1:2000SEP082344908F6 1448 1999 87 LG:1101317.1:2000SEP082344908H1 1448 1719 87 LG:1101317.1;2000SEP086303664H1 1461 1748 87 LG:I 101317.1;2000SEP081643051 H1 896 1111 87 LG:1101317.1:2000SEP08g2069483 923 1308 87 LG:1101317.1;2000SEP087762822H 806 1197 87 LG;1101317.1;2000SEP087762822) 806 1197 87 LG:1101317.1:2000SEP087712440) 876 1486 1.52 SEQ ID Template ID Component Start Stop NO: ID

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95 LG:1079470,b:2000SEP083946142F8 658 1195 95 LG:1079470,6:2000SEP0863894286 662 1217 95 LG:1079470.6:2000SEP082550648F6 662 1027 95 LG:1079470,6:2000SEP08638942H1 662 917 95 LG:1079470.b:2000SEP082550648H 662 904 95 LG:1079470.b:2000SEP085219834H2 687 921 95 LG:1079470.6:2000SEP0854374886 480 1034 95 LG:1079470.b:2000SEP085546359H1 484 677 95 LG:1079470,b:2000SEP085219834F7 690 1243 95 LG:1079470,6:2000SEP082318794H1 715 860 95 LG:1079470.6:2000SEP085202357H1 763 985 95 LG:1079470,6:2000SEP083466746H 764 1006 95 LG:1079470,6:2000SEP08g1302678 799 1071 95 LG:1079470.6;2000SEP082050882H1 825 1077 95 LG:1079470,6:2000SEP082733580H 871 1094 95 LG:1079470,6:2000SEP084919329H1 893 1119 95 LG:1079470.b:2000SEP086167338H1 947 1025 95 LG:1079470,b:2000SEP086060464F8 411 1027 95 LG:1079470,6:2000SEP085996080F8 411 937 95 LG:1079470.b:2000SEP081451495F6 448 1072 95 LG:1079470.6:2000SEP081451495F1 448 917 95 LG:1079470,6:2000SEP081451495H1 448 695 95 LG:1079470.6:2000SEP08543748H 1 480 708 95 LG:1079470.b:2000SEP0854374881 480 865 95 LG:1079470,6:2000SEP085761741H1 299 577 95 LG:1079470.6:2000SEP084717311 H 302 535 95 LG:1079470.6:2000SEP08299i334Hi 80 419 95 LG:1079470,6:2000SEP08gb197278 293 750 95 LG:1079470,6:2000SEP085757130F8 296 883 95 LG:1079470.b:2000SEP085757130H1 296 576 95 LG:1079470.6:2000SEP085996080H 411 684 95 LG:1079470.6:2000SEP086541925H1 325 851 95 LG:1079470,6:2000SEP08g965206 353 699 95 LG:1079470,b:2000SEP084717311 F8 325 823 95 LG:1079470.b:2000SEP086779294H 372 944 95 LG:1079470,6:2000SEP082266214H1 382 648 95 LG:1079470.6:2000SEP085996080F7 41 T 9i9 95 LG:1079470,6:2000SEP085992238H1 411 700 96 LG:345705,3:2000SEP086866333H1 1 508 96 LG:345705,3:2000SEP086743970H 78 400 96 LG:345705.3:2000SEP085903130H1 1 270 9b LG:345705.3:2000SEP083134791 H 209 481 97 LG:1083b54,1:2000SEP08296137376 2740 2962 97 LG:1083654.1:2000SEP08243195H 1 2742 2862 97 LG:1083654.1:2000SEP082961373F6 2747 2997 97 LG:1083654.1:2000SEP082961373H 2749 2877 97 LG: 7083654, i 5308958H 2786 3006 :2000SEP08 1 97 LG:1083654.1:2000SEP081251913H 2867 3008 SEQ ID Template ID Component Start Stop NO: ID

97 LG;1083b54.1;2000SEP081251913F6 2873 2951 97 LG:1083654.1:2000SEP08285359176 2884 3294 97 LG:1083654.1;2000SEP08171277876 2965 3407 97 LG:1083b54.1:2000SEP088897183 3094 3370 97 LG:1083654.1:2000SEP087932016H1 3113 3732 97 LG:1083654.1:2000SEP0882057056 2249 2605 97 LG:1083b54.1;2000SEP08655886578 2319 2892 97 LG:1083b54.1:2000SEP081712778H1 2320 2534 97 LG:1083654.1:2000SEP081712778F6 2320 2857 97 LG:1083654.1:2000SEP084787383H1 2530 2781 97 LG:1083b54.1;2000SEP0884629623 2555 3002 97 LG:1083654.1;2000SEP0885512397 2563 3003 97 LG;1083654.1:2000SEP0885661867 2578 3033 97 LG:1083654.1:2000SEP085445604H1 2591 2832 97 LG:1083b54.1:2000SEP0885511864 2593 3003 97 LG;1083654.1:2000SEP0882070577 2641 3010 97 LG:1083b54.1:2000SEP0884334177 2644 3011 97 LG:1083b54.1;2000SEP0882715986 2678 3002 97 LG:1083654.1:2000SEP086513330H1 2735 3027 97 LG:1083b54.1:2000SEP087664249H 250 808 97 LG:1083b54.1;2000SEP087011821 H1 430 863 97 LG:1083654.1;2000SEP0886438877 427 839 97 LG:1,083654.1:2000SEP0883679253 430 886 97 LG:1083b54.1:2000SEP0885231632 430 849 97 LG:1083b54.1;2000SEP0883665440 430 880 97 LG;1083654.1:2000SEP0885554573 430 894 97 LG:1083654.1;2000SEP0886040151 433 870 97 LG:1083654.1;2000SEP08g 1242884 435 770 97 LG:1083654.1:2000SEP0884190333 436 814 97 LG;1083654.1:2000SEP08569484176 481 910 97 LG:1083654.1;2000SEP0882240560 494 973 97 LG:1083654.1;2000SEP08g 1367813 558 1328 97 LG:1083654.1:2000SEP085695241 T8 635 1078 97 LG:1083b54.1;2000SEP08g 1367787 750 1356 97 LG:1083654.1:2000SEP084031856H 991 1223 97 LG;1083654.1:2000SEP0886986275 1015 1569 97 LG:1083654.1:2000SEP086558865F8 1261 1866 97 LG:1083654.1:2000SEP086558865H1 1261 1764 97 LG;1083654.1:2000SEP087664249) 1363 1917 97 LG:1083b54.1;2000SEP085695241F9 1382 1960 97 LG:1083654.1:2000SEP084249967H1 1401 1654 97 LG:1083b54.1:2000SEP084798922H1 1552 1795 97 LG:1083b54.1;2000SEP082853591F6 1617 1985 97 LG:1083b54.1:2000SEP082853591H1 1617 1703 97 LG;1083b54.1:2000SEP085694841F6 1665 1956 97 LG;1083b54.1;2000SEP081962583H 1668 1933 97 LG:1083654.1:2000SEP086843753F8 1691 2211 97 LG:1083654.1:2000SEP086843753H1 1691 2271 SEQ ID Template ID Component Start Stop NO; ID

97 LG:1083b54.1:2000SEP085695241H1 1737 1960 97 LG:1083654.1;2000SEP084245847H1 1748 2009 97 LG;1083654.1:2000SEP084245325H1 1749 2014 97 LG:1083654.1:2000SEP084245361H1 1749 2013 97 LG:1083654.1:2000SEP083515501H1 1837 2080 97 LG:1083654.1:2000SEP082551309H1 2173 2418 97 LG:1083654.1:2000SEP087169394H 1 119 97 LG:1083b54.1:2000SEP08377885978 1 328 97 LG;1083b54.1:2000SEP08377885979 1 362 97 LG:1083b54.1.:2000SEP083778859F8 1 486 97 LG;1083b54.1:2000SEP083778859H 2 309 97 LG:1083654.1;2000SEP083778859F9 1 489 98 LG:198782.3:2000SEP083733962H1 6 299 98 LG;198782.3:2000SEP08g6946984 33 479 98 LG:198782.3:2000SEP081993570H 36 246 98 LG;198782.3:2000SEP081993470H 36 294 98 LG:198782.3:2000SEP081993570F6 36 514 98 LG:198782.3:2000SEP087727533)1 42 271 98 LG:198782.3:2000SEP087727533H1 57 275 98 LG:198782.3;2000SEP083232864H1 72 349 98 LG:198782.3:2000SEP08g2575182 80 444 98 LG;198782.3;2000SEP085375624H1 114 358 98 LG;198782.3:2000SEP085605969H1 181 450 98 LG;198782.3:2000SEP08g4458155 311 756 98 LG:198782.3:2000SER08g 1933416 316 808 98 LG:198782.3:2000SEP08g1924157 365 720 98 LG;198782.3:2000SEP084023516H1 383 688 98 LG:198782.3:2000SEP084165481 H 384 669 98 LG:198782.3;2000SEP084172681H1 383 645 98 LG;198782.3:2000SEP08g2219275 389 791 98 LG:198782.3:2000SEP087184257H1 456 1030 98 LG:198782.3:2000SEP08g 1526024 575 1045 98 LG;198782.3:2000SEP08g 1266311 625 888 98 LG;198782.3:2000SEP08g723408 672 951 98 LG:198782.3;2000SEP08g3070857 730 1203 98 LG:198782.3;2000SEP08g1933415 730 1187 98 LG:198782.3:2000SEP087213803H1 758 1175 98 LG;198782.3:2000SEP082433334H 769 982 98 LG:198782.3:2000SEP08g5854526 775 1200 98 LG;198782.3:2000SEP08g3784943 779 1203 98 LG;198782.3:2000SEP08g 1923460 785 1195 98 LG:198782.3:2000SEP084270541 H 811 1061 98 LG:198782.3:2000SEP08g 1525917 823 1200 98 LG:198782.3:2000SEP087090529H1 828 1374 98 LG;198782.3:2000SEP08g724366 842 1194 98 LG:198782.3:2000SEP08g5233108 862 ~ 1194 98 LG:198782.3:2000SEP08g2357872 906 1193 98 LG:198782.3:2000SEP08g2000179 1932 2187 _ SEQ ID Template ID Component Start Stop NO: ID

98 LG:198782.3:2000SEP08g2000178 1932 2136 98 LG;198782.3;2000SEP086782233H 1820 2357 98 LG:198782.3;2000SEP087740905J1 1943 2550 98 LG:198782.3;2000SEP08g2715455 1696 2034 98 LG;198782.3;2000SEP083094122F6 1710 2122 98 LG;198782.3;2000SEP083094122H1 1710 1980 98 LG;198782.3;2000SEP086943391 H1 1759 2247 98 LG;198782.3;2000SEP087743465H1 1324 1941 98 LG:198782.3;2000SEP087740905H1 1566 ' 2180 98 LG:198782.3:2000SEP083069437F6 1148 1287 98 LG:198782.3;2000SEP083069437H1 1148 1418 98 LG:198782.3;2000SEP087042063H1 1207 1752 98 LG:198782.3:2000SEP08g1481929 1221 1671 98 LG;198782.3;2000SEP083382159H1 1 249 98 LG;198782.3:2000SEP083349345H1 1 218 98 LG;198782.3:2000SEP08g4435439 1 468 98 LG;198782.3:2000SEP086723501 H 2086 2517 98 LG;198782.3:2000SEP087727032H 2138 2554 98 LG:198782.3:2000SEP087591969H1 2241 2667 98 LG:198782.3:2000SEP086782233) 2352 2979 98 LG;198782.3:2000SEP08171482H 1 2396 2606 98 LG:198782.3:2000SEP08g2779400 913 1197 99 LG;981076.2;2000SEP087169509H1 1 476 99 LG;981076.2:2000SEP087409370H1 2 577 99 LG:981076.2;2000SEP086768733H1 57 291 99 LG:981076.2:2000SEP083176620H 65 319 99 LG:981076.2:2000SEP083176620F6 65 550 99 LG:981076.2;2000SEP084613367H1 71 325 99 LG;981076.2;2000SEP083082646H1 122 414 99 LG:981076.2:2000SEP083504115H1 161 476 99 LG:981076.2;2000SEP08g5178468 189 666 99 LG;981076.2:2000SEP08259700H1 1 277 99 LG;981076.2:2000SEP08351753386 331 652 99 LG:981076.2:2000SEP083517533H1 331 620 100 LG:212023.3:2000SEP081438825H1 226 479 100 LG;212023.3:2000SEP081438827H1 226 477 100 LG;212023.3:2000SEP085054201H1 234 536 100 LG:212023.3;2000SEP085054201 F6 239 743 100 LG:212023.3:2000SEP083699764H1 255 442 100 LG:212023.3:2000SEP084871594H1 276 522 100 LG:212023.3:2000SEP08g3215183 314 754 100 LG;212023.3:2000SEP08g2703431 326 761 100 LG:212023.3;2000SEP085654058H1 471 844 100 LG:212023.3:2000SEP082988962H 478 76b 100 LG;212023.3;2000SEP081387482H1 483 712 100 LG:212023.3;2000SEP08g2046330 598 933 100 LG:212023.3:2000SEP08068454H 1 656 808 100 LG;212023.3:2000SEP085654801 H1 693 981 SEQ ID Template ID ' Component Start Stop NO; ID

100 LG:212023.3:2000SEP08g2106581 852 1214 100 LG:212023.3:2000SEP08594131476 994 11 b8 100 LG;212023.3:2000SEP085941314H1 993 1215 100 LG;212023.3:2000SEP081925734H1 1106 1333 100 LG:212023.3:2000SEP08192573476 1106 1316 100 LG:212023.3:2000SEP08192573486 1106 1316 100 LG:212023.3:2000SEP081438827F6 226 653 100 LG:212023.3:2000SEP08614697H1 1 233 100 LG:212023.3:2000SEP081284208F6 70 504 100. LG;212023.3:2000SEP081284208H1 70 255 100 LG:212023.3:2000SEP084828893H 1 115 341 100 LG;212023.3:2000SEP084873560H1 202 426 100 LG;212023.3:2000SEP084872742H1 218 488 1 O1 LG:977929.3:2000SEP086480392H 1 1 496 1 O1 LG:977929.3:2000SEP086480523H 1 1 479 1 O1 LG:977929.3:2000SEP08g 1974709 1 227 101 LG:977929.3:2000SEP08861670H1 8 274 101 LG;977929.3:2000SEP08g1988875 15 300 101 LG;977929.3;2000SEP083350527H1 62 153 102 LG;201936.6:2000SEP085089364F6 1 442 102 LG:201936.6:2000SEP085089364H 1 1 254 102 LG;201936.6;2000SEP085047236H1 283 536 102 LG:201936.6:2000SEP08649419489 413 987 102 LG:201936.6:2000SEP083590431 H ~ 520 836 102 LG;20193b.6:2000SEP085562609H1 585 804 102 LG:201936.6:2000SEP085562609F6 585 1000 102 LG:201936.b:2000SEP085137081 H 688 973 103 LG:205b42.1:2000SEP081787609H1 . 675. 911 103 LG;205642.1;2000SEP08631267678 866 1296 103 LG:205642.1:2000SEP08627470978 881 1354 103 LG:205b42.1:2000SEP08355515276 886 1382 103 LG:205642.1:2000SEP084753183H1 1294 1430 103 LG;205b42.1:2000SEP082120129H1 1 238 103 LG:205b42.1:2000SEP086312676H1 151 686 103 LG;205b42.1;2000SEP086273658F8 407 1073 103 LG;205642.1:2000SEP086274709H2 408 526 103 LG:205642.1:2000SEP083555152F6 497 924 103 LG;205b42.1:2000SEP083555152H1 497 782 104 LG:339653.6:2000SEP086038578H 1 7 301 104 LG;339653.6:2000SEP085957411H1 1 285 104 LG:339653.6:2000SEP086040578H 1 7 319 105 LG:978587.4:2000SEP08259209576 1 318 105 LG:978587.4;2000SEP08g6075351 143 601 105 LG:978587.4:2000SEP085000079H2 264 525 105 LG;978587.4:2000SEP084666688H1 328 521 105 LG:978587.4:2000SEP084666688F6 328 620 105 LG:978587.4:2000SEP084048832H 1 402 701 105 LG:978587.4:2000SEP08g2103012 485 712 SEQ ID Template ID Component Start Stop NO: ID

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109 LI:231024.2:2000SEP082078150H 1 742 1004 109 LI;231024.2;2000SEP08g3092119 932 1417 109 LI:231024.2:2000SEP086725205H1 1 614 109 L1;231024.2:2000SEP08654199178 6b 662 109 LI;231024.2:2000SEP085964b4379 122 634 109 LI:231024.2;2000SEP08g2783200 342 848 109 LI;231024.2:2000SEP08g272b574 949 11 b9 109 Li:231024.2:2000SEP087684929H1 951 1478 109 LI:231024.2:2000SEP087683622H 1 951 1456 109 LI;231024.2:2000SEP087b82580H1 951 1457 109 LI:231024.2;2000SEP086713531H1 1171 1539 109 L1:231024.2:2000SEP08g55411 b9 1221 1545 109 LI:231024.2:2000SEP08g2958236 1228 1416 109 LI:231024.2;2000SEP08161875676 1249 1843 109 LI;231024.2:2000SEP087618177)1 1631 2103 109 LI;231024.2:2000SEP0819435b5H1 1700 1879 109 L1;231024.2:2000SEP0841451 b8H 829 1121 110 LI;228425.5:2000SEP088018076)1 184 780 110 LI:228425.5:2000SEP087589727H1 157 769 110 LI;228425.5;2000SEP087601932H1 425 b92 110 LI;228425.5:2000SEP087601924H1 502 692 110 LI;228425.5:2000SEP087601932)1 425 690 110 LI;228425.5;2000SEP087611327)1 22 658 110 LI:228425.5:2000SEP087743111H1 31 642 110 LI;228425.5:2000SEP088036091 J 123 643 110 LI:228425.5;2000SEP087601924)1 452 607 110 L1:228425.5:2000SEP088025995)2 27 575 110 LI:228425.5:2000SEP087627bO6H 1 1 518 110 LI:228425.5:2000SEP087750637) 1 158 419 110 LI;228425.5;2000SEP087983232H1 268 832 110 LI:228425.5:2000SEP0870942464V1 435 1030 110 L1:228425.5:2000SEP088018642) 1 353 989 110 LI:228425.5:2000SEP087667b52H1 261 836 111 LI:034493.1:2000SEP087016835H1 1 585 111 LI:034493.1;2000SEP08525053H1 35 267 111 LI:034493.1:2000SEP08g1b177b0 129 485 111 LI;034493.1:2000SEP087994078H1 474 996 112 LI;336218.1:2000SEP083154167H1 14 284 112 LI:336218.1:2000SEP085407028H1 14 216 112 LI:336218.1;2000SEP083267888H1 14 250 112 LI:336218.1:2000SEP085715861 H 31 501 112 LI;33b218.1:2000SEP082475067F6 41 400 112 LV:336218.1:2000SEP082475067H1 41 243 112 LI:336218.1:2000SEP083674722H 1 142 432 112 LI:33b218.1;2000SEP0829b4579H1 1b9 445 112 LI:33b218.1:2000SEP0860136174D1 241 424 112 LI;336218.1:2000SEP082475067Th 335 703 112 LI;336218.1;2000SEP087183496H1 8 512 SEQ ID Template ID Component Start Stop NO. ID

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140 LI;414253.1:2000SEP086882657H1 1572 2123 140 LI:414253.1;2000SEP0871022138V1 1579 2095 140 LI;414253.1:2000SEP087T240477VT 1598 1700 140 LI:414253.1;2000SEP085259755H 1 1700 1866 140 LI;414253.1:2000SEP0871020549V1 1732 2152 140 LI:414253.1:2000SEP086894886) 1 1734 2325 140 LI:414253.1:2000SEP0871020631 V 1920 2155 140 LI:414253.1:2000SEP087073747H1 1 544 140 LI:414253.1;2000SEP086765077H1 1900 2426 140 LI;414253.1;2000SEP086894886H1 1905 2510 i40 LI:414253.1:2000SEP0877022463V1 1906 2393 140 LI;414253.1:2000SEP08~71021156V1 1911 2555 140 LI:414253.1;2000SEP0871019356V1 1080 1765 140 LI:414253.1:2000SEP0871022935V1 1103 1573 140 LI;414253.1:2000SEP0871019614V1 1202 1344 140 LI;414253.1:2000SEP087115421H1 1209 1756 140 LI:414253.1:2000SEP087112040H2 1209 1703 140 LI:414253.1:2000SEP087112740H2 1209 1782 140 LI;414253.1:2000SEP0871019475V1 1224 1515 140 LI:414253.1:2000SEP0871021555V1 1224 1515 140 LI:414253.1:2000SEP084707917H1 1257 1525 140 LI:414253.1;2000SEP084692502H 1 1267 1520 140 LI:414253.1;2000SEP0871033330V1 1304 1472 140 LI:414253.1;2000SEP081945748H 1 1323 1553 140 LI;414253.7:2000SEP08g771044 1331 1712 140 LI:414253.1:2000SEP081543574H1 1358 1573 140 LI:414253.1:2000SEP08154357486 1358 1885 140 LI:414253.1:2000SEP087068113H1 1362 1955 140 LI:414253.1:2000SEP0871020257V1 1391 1920 140 LI:414253.1:2000SEP08925902H 1 1392 1585 140 LI:414253.1;2000SEP0871022851 V1 1405 1966 140 LI;414253.1;2000SEP0867580788 1415 1554 140 LI:414253.1:2000SEP08675807H1 1415 1554 140 LI:414253.1:2000SEP0867580786 1415 1554 140 LI;414253.1:2000SEP087292014H1 1052 1524 140 LI:414253.1;2000SEP082039968H1 1069 1346 140 LI:414253.1:2000SEP0871021025V 1072 1573 140 LI:414253.1;2000SEP085683551 F6 1000 1379 140 LI;414253.1;2000SEP0871020667V1 985 1259 140 LI;414253.1:2000SEP0871019368V1 1000 1454 140 LI:414253.1:2000SEP085683551 H 1000 1272 140 LI:414253.1:2000SEP0867580787 1415 1554 140 LI;414253.1:2000SEP0871034573V1 1830 1976 140 LI:414253.1;2000SEP0871237928V1 1842 2370 140 LI:414253.1:2000SEP081397602H1 686 775 140 LI:414253.1;2000SEP087287151 H 750 1231 140 LI:414253.1:2000SEP081417182H 1 536 764 140 LI:414253.1:2000SEP086888331)1 930 1518 SEQ ID Template ID Component Start Stop NO; ID

140 LI:414253.1:2000SEP0871020886V1 1837 2393 140 LI:4i4253.1:2000SEP087997345H1 346 609 140 LI:414253.1:2000SEP08623096T6 1940 2533 140 LI:414253.1;2000SEP084343090H1 1947 2034 140 LI;414253.1;2000SEP085965294F8 1990 2570 140 LI:414253.1;2000SEP081543574Th 2029 2533 140 LI:414253.1:2000SEP082044247H1 2054 2322 140 LI;414253.1:2000SEP08204424786 2054 2393 140 LI;414253.1:2000SEP087060219H1 2077 2569 140 LI:414253.1;2000SEP088315040 2112 2572 140 LI:414253.1:2000SEP0886228972 2113 2569 140 LI;414253.1:2000SEP0871019196V1 2131 2570 140 LI:414253.1;2000SEP0871021676V1 2121 2589 140 LI;414253.1:2000SEP087578441 H2 2137 2324 140 LI;414253.1:2000SEP082043595H1 2214 2393 140 LI:414253.1:2000SEP088872878 2238 2579 140 LI;414253.1;2000SEP088819699 2270 2582 140 LI:414253.1:2000SEP082407286H1 2294 2522 i 40 LI:414253.1;2000SEP086882657) 1 2315 2508 140 LI:414253.1;2000SEP082157543H 1 2430 2526 140 LI:414253.1:2000SEP082157543T6 2431 2532 140 LI:414253.1;2000SEP082157543F6 2430 2569 140 LI:414253.1:2000SEP08674031 6H 2458 2560 141 LI:40b389.1:2000SEP086870105H1 1151 1588 141 LI;40b389.1;2000SEP086870968H l 1155 1673 141 LI:406389.1;2000SEP0883805640 1188 1567 141 LI:406389. i :2000SEP0885b 1297 1227 1562 141 LI:40b389.1;2000SEP088795551 1252 1573 141 LI;406389.1;2000SEP088683370 1276 1562 141 LI:40b389.1;2000SEP088214i 803 1405 1567 141 LI;40b389.1:2000SEP084788627Th 1454 1521 141 LI:406389.1:2000SEP084766304H 1 699 971 141 LI:406389.1:2000SEP08921701H1 930 1252 141 LI:40b389.1:2000SEP087091595H1 932 1469 141 LI:40b389.1:2000SEP084766304Th 1133 1520 141 LI;40b389.1;2000SEP0883308722 1149 1562 141 LI:40b389.1;2000SEP0884264177 1 481 141 LI:40b389.1:2000SEP086768921 J 10 579 141 LI;40b389.1:2000SEP086767668) 1 10 471 141 LI:40b389.1:2000SEP083787648H1 391 669 141 LI:40b389.1;2000SEP088709143 404 717 141 LI:406389.1:2000SEP088570324 420 741 141 LI:40b389.1:2000SEP088694218 516 743 141 LI:40b389.1;2000SEP083574983N 1 651 940 141 LI;406389.1:2000SEP0881809833 651 913 141 LI:40b389.1:2000SEP084766304F6 699 1072 142 LI:1086171.1:2000SEP086796022F8 1 550 142 LI:108b171.1:2000SEP086796022H1 1 575 SEQ ID Template ID Component Start Stop NO: ID

142 LI:108b171.1:2000SEP08679602278 1 463 143 L!;198782.4:2000SEP087753061 J 4352 5049 143 LI:198782.4:2000SEP085778688H1 4358 4623 143 LI;198782.4;2000SEP08626505H1 4364 4633 143 LI;198782.4:2000SEP083620066H1 4365 4655 143 LI:198782.4:2000SEP086206412H1 4377 4941 143 LI:198782.4;2000SEP082969374H1 4386 4695 143 LI:198782.4;2000SEP081208501 R1 4417 4986 143 LI;198782.4:2000SEP081208501 H 4417 4656 143 LI;198782.4;2000SEP0885593068 4436 4933 143 LI;198782.4:2000SEP0872278681 4460 5054 143 LI:198782.4:2000SEP08722786H1 4460 4749 143 LI:198782.4:2000SEP085196343H1 4466 4740 143 LI;198782.4:2000SEP08g 1802558 3537 3893 143 LI:198782.4:2000SEP088124049H1 3532 4154 143 LI: i 98782.4;2000SEP084783988H 1 4687 4927 143 LI:198782.4:2000SEP083434336H 1 4709 4904 143 LI;198782.4;2000SEP087749827) 1 4719 5327 143 LI:198782.4;2000SEP083379948H1 3338 3615 143 LI:198782.4:2000SEP082174420F6 3426 3943 143 LI;198782.4;2000SEP082174420H1 3427 3668 143 LI:198782.4:2000SEP086348086H1 3449 3737 143 LI;198782.4;2000SEP087634241 J 3466 4048 143 LI:198782.4:2000SEP084289769H 1 3503 3763 143 LI;198782.4:2000SEP084174741 H 3506 3806 143 LI:198782.4;2000SEP085980307H1 3522 3822 143 LI;198782.4:2000SEP085088691 H 3529 3784 143 LI:198782.4:2000SEP08407900H1 4804 5045 143 LI:198782.4:2000SEP082972377H1 4812 5119 143 LI:198782.4;2000SEP08220b290Hi 4845 5110 143 LI:198782.4:2000SEP08177338676 4848 5323 143 LI;198782.4:2000SEP08177338686 4849 5361 143 LI;198782.4:2000SEP081916583H 1 4849 5112 143 LI:198782.4;2000SEP0881873598 4853 5354 143 LI:198782.4:2000SEP0885236486 4875 5354 i 43 Ll: i 98782.4;2000SEP0886575406 4888 5354 143 LI;198782.4:2000SEP0885812818 4890 5354 143 LI:198782.4:2000SEP083382159H1 1 251 143 LI:198782.4;2000SEP08" 84435439 1 470 143 LI;198782.4:2000SEP083349345H 1 3 220 143 LI:198782.4:2000SEP08g 1203045 4891 5190 143 LI:198782.4:2000SEP0883596839 4895 5363 143 LI:198782,4:2000SEP0885426010 4898 5354 143 LI:198782.4:2000SEP083620979H1 4899 5185 143 LI:198782.4:2000SEP08290991 OH 4323 4575 143 LI: i 98782.4:2000SEP08g 1982687 4332 4617 143 LI:198782.4:2000SEP08.6361528H2 3566 4075 143 LI:198782.4:2000SEP083687346H1 3633 3907 -SE6~ Template ID Component Start Stop ID NO: ID

143 LI:198782,4:2000SEP084691212H1 3635 3899 143 LI:198782.4:2000SEP082972069H 1 3637 3959 143 LI:198782,4:2000SEP087698932H 1 3722 4404 143 LI:198782,4:2000SEP08g783276 3735 3943 143 LI:198782.4:2000SEP084891359H 1 3793 4054 143 LI:198782,4:2000SEP084780573H1 3803 4015 143 LI: i 98782.4:2000SEP085377536H 1 3827 4061 143 LI:198782,4:2000SEP082813773F6 3837 4403 143 LI:198782,4:2000SEP082813773H 1 3838 4118 143 LI:198782.4:2000SEP082294301 R6 3886 4404 143 L1:198782,4:2000SEP082294301 H 3886 4149 143 LI:198782.4:2000SEP082653851 H1 3901 4196 143 LI.198782.4:2000SEP08662328H1 3944 4198 143 LI:198782,4:2000SEP083529451 H1 3961 4274 143 LI:198782.4:2000SEP081878246F6 3967 4265 i43 LI:198782,4:2000SEP081878246H1 3967 4168 143 LI: i 98782,4:2000SEP082540450H 1 3971 4229 143 LI:198782.4:2000SEP08880264H1 3994 4297 143 LI:198782.4:2000SEP0875397581 4022 4558 143 LI:198782.4:2000SEP086518464H 1 4078 4679 143 LI:198782.4:2000SEP081393486H1 4078 4261 743 LI:198782,4:2000SEP083243025H1 4078 4261 143 LI:198782,4:2000SEP08753975H1 4078 4220 143 LI:198782,4:2000SEP084775758H1 4081 4352 143 L1:198782.4:2000SEP081415015H 1 4122 4397 143 L1:198782.4:2000SEP086309993H1 ~ 4150 4680 143 LI:198782,4:2000SEP08g1873712 4182 4584 143 LI:198782.4:2000SEP081463313H 1 4205 4453 143 LI:198782,4:2000SEP082287535H1 4218 4356 143 LI:198782,4:2000SEP082957618H1 4220 4382 143 LI: i 98782.4:2000SEP084539614H 1 4252 4432 143 LI:198782,4:2000SEP082608763H2 4252 4495 143 LI:198782,4:2000SEP086518447H1 4289 4679 143 LI:198782,4:2000SEP081512393H1 4305 4507 143 LI:198782,4:2000SEP085518530H1 4311 4478 143 LI:198782.4:2000SEP086328279H1 4602 5114 143 L1:198782.4:2000SEP086335657H1 4602 4755 143 LI:198782.4:2000SEP081495153H1 4620 4852 143 LI:198782,4:2000SEP083727136H1 4641 4951 143 LI:198782,4:2000SEP084216627H1 4652 4930 143 LI:198782.4:2000SEP082298651H1 4655 4923 143 LI:198782.4:2000SEP082924824H 1 4658 4936 143 LI:198782,4:2000SEP083733962H1 8 301 143 LI:198782.4:2000SEP08g6946984 35 481 143 LI:198782.4:2000SEP081993570F6 38 517 143 LI: i 98782.4:2000SEP081993470H 1 38 296 143 LI:198782.4:2000SEP08~ 1993570H 38 248 143 LI:198782,4:2000SEP087727533J1 44 273 SEQ ID Template ID Component Start Stop NO: ID

143 LI;198782.4:2000SEP087727533H 1 59 277 143 Ll: i 98782.4:2000SEP083232864H 1 74 351 143 LI:198782.4:2000SEP08g2575182 82 446 143 LI:198782.4:2000SEP085375624H1 116 358 143 LI;198782.4;2000SEP085605969H1 183 452 143 LI:198782.4:2000SEP088024696) 1 227 856 143 LI:198782.4:2000SEP08g4458155 313 761 143 LI;198782.4;2000SEP08g1933416 318 812 143 LI:198782.4:2000SEP08g 1924157 367 724 143 LI:198782.4:2000SEP08402351 6H 385 . 691 143 LI:198782.4:2000SEP084165481 H 386 672 143 LI:198782.4:2000SEP084172681 H 385 648 143 LI:198782.4:2000SEP08g2219275 391 797 143 LI:198782.4:2000SEP087184257H1 458 1043 143 LI:198782.4:2000SEP08g 1526024 578 1058 143 LI:198782.4;2000SEP0881266311 628 897 143 LI;198782.4;2000SEP088723408 675 963 143 LI:198782.4;2000SEP0883070857 735 1217 143 LI;198782.4:2000SEP08g 1933415 735 1201 143 LI:198782.4;2000SEP087213803H1 763 1189 143 LI:198782.4;2000SEP082433334H1 775 995 143 LI:198782.4:2000SEP0885854526 781 1214 143 LI:198782.4:2000SEP0883784943 785 1217 143 LI:198782.4:2000SEP08g 1923460 791 1209 143 LI;198782.4:2000SEP084270541 H 818 1075 143 LI:198782.4;2000SEP0881525917 830 1214 143 LI:198782.4:2000SEP087090529H1 835 1392 143 LI:198782.4:2000SEP088724366 849 1208 143 LI:198782.4:2000SEP0885233108 870 1208 143 LI:198782.4;2000SEP0882357872 916 1207 143 LI;198782.4;2000SEP0882779400 923 1211 143 LI:198782.4:2000SEP083069437H 1 11 b2 1437 143 LI;198782.4:2000SEP083069437F6 1162 1301 143 LI;198782.4:2000SEP087042063H 1 1221 1772 143 LI:198782.4:2000SEP08g 1481929 1235 1691 143 LI:198782.4:2000SEP087743465H1 1338 1963 143 LI:198782.4:2000SEP087740905H 1 1586 2208 143 LI:198782.4:2000SEP0882715455 1716 2058 143 LI:198782.4:2000SEP083094122F6 1730 2149 143 LI:198782.4:2000SEP083094122H1 1730 2002 143 LI:198782.4:2000SEP086943391 H 1779 2275 l 143 LI:198782.4;2000SEP086782233H1 1841 2390 143 LI:198782.4:2000SEP0882000179 1954 2215 143 LI:198782.4:2000SEP0882000178 1954 21 b4 143 LI;198782.4:2000SEP087740905) 1 1965 2586 143 LI:198782.4;2000SEP086723501H1 2114 2553 143 LI: i 98782.4;2000SEP088124509H i 2 i 39 279 i 143 LI:198782.4:2000SEP087727032H1 2166 2590 -SEQ ID Template ID Component Start Stop NO: ID

143 LI:198782.4;2000SEP08759i9b9H1 2274 2703 143 LI:198782.4:2000SEP086782233) 1 2385 3017 143 LI:198782.4:2000SEP08171482H1 2429 2642 143 LI:198782.4:2000SEP088003320H1 2718 3298 143 LI:198782.4;2000SEP088004370H1 2718 3203 143 LI:198782.4:2000SEP086607576H1 2819 3350 143 LI:198782.4:2000SEP087698932) 1 2850 3322 143 LI:198782.4;2000SEP082069005H1 2880 3155 143 LI;198782.4:2000SEP087387576H1 2967 3545 143 LI:198782.4;2000SEP087730026)1 2990 3537 143 LI:198782.4:2000SEP086751302H1 2992 3574 143 LI:198782.4:2000SEP087634241 H 3019 3581 143 LI:198782.4:2000SEP083605946H1 3040 3363 143 LI:198782.4:2000SEP082717553F6 3050 3596 143 LI:198782.4:2000SEP082717553H1 3050 3319 143 LI:198782.4:2000SEP082670755H1 3050 3294 143 LI:198782.4:2000SEP08306943786 3069 3550 143 LI:198782.4;2000SEP08g6438212 3118 3588 143 LI:198782.4:2000SEP0843324b7Hi 3184 3274 143 LI;198782.4;2000SEP082723120H1 3201 3460 143 LI:198782.4:2000SEP087749827H1 3236 3784 143 LI:198782.4;2000SEP086584914H1 3293 3604 143 LI:198782.4:2000SEP08g825991 3338 3744 143 LI:198782.4:2000SEP086172567H1 4733 5040 143 LI;198782.4;2000SEP08281377376 4735 5316 143 LI:198782.4:2000SEP082222943H 1 4757 5024 143 LI:198782.4:2000SEP08271755376 4769 5319 143 LI:198782.4:2000SEP08539612471 4769 5268 i 43 LI: i 98782.4:2000SEP084650454H 1 4769 5047 143 LI.198782.4:2000SEP08g1238470 4772 5001 143 LI:198782.4:2000SEP08g867285 4793 5139 143 LI:198782.4:2000SEP08g789023 4792 5039 143 LI:198782.4:2000SEP0840790086 4804 5101 143 LI:198782.4:2000SEP087345790H1 4482 5102 143 LI;198782.4;2000SEP084139428H1 4480 4798 143 LI:198782.4:2000SEP081910341 H 4543 4796 i 143 LI:198782.4:2000SEP084893581 H 4581 4859 143 LI:198782.4:2000SEP085207501 H1 4581 4768 143 LI:198782.4:2000SEP085153162H1 4592 4710 143 LI:198782.4:2000SEP087753061 H 3542 4095 143 LI:198782.4:2000SEP088124058H1 3532 4141 143 LI:198782.4:2000SEP08g3988960 4901 5362 143 LI:198782.4:2000SEP08309412276 4904 5307 143 LI;198782.4:2000SEP08g5741223 4909 5357 143 LI:198782.4;2000SEP08g3038341 4910 5354 143 LI;198782.4:2000SEP08g3770738 4911 5359 143 LI:198782.4:2000SEP08217442076 4913 5315 143 LI:198782.4:2000SEP08_g38_42608 4923 5354 ___ SEQ ID Template ID Component Start Stop NO: ID

143 LI:198782.4:2000SEP081485957H1 4930 5223 143 LI:198782.4;2000SEP0840790076 4948 5329 143 LI:198782.4:2000SEP0884737776 4954 5354 143 LI:198782.4:2000SEP082294301 T6 4965 5316 143 LI:198782.4:2000SEP0882445541 4968 5361 143 LI;198782.4:2000SEP082569859H 1 4983 5254 143 LI;198782.4:2000SEP0882401656 4986 5354 143 LI:198782.4;2000SEP084314015H1 5000 5319 143 LI:198782.4:2000SEP0882902280 5002 5354 143 LI:198782.4;2000SEP0885862936 5010 5385 143 LI;198782.4:2000SEP081371538H 1 5020 5225 143 LI:198782.4;2000SEP082422265H1 5021 5291 143 LI:198782.4:2000SEP08366679H1 5033 5300 143 LI;198782.4:2000SEP0885546865 5044 5355 143 LI:198782.4:2000SEP0885541555 5059 5361 143 LI;198782.4:2000SEP087734334H2 5133 5354 143 LI:198782.4:2000SEP088867243 5123 5328 143 LI:198782.4:2000SEP088788934 5130 5351 143 LI;198782.4:2000SEP084515811 H 5130 5335 T 43 LI;198782.4:2000SEP082581176H 1 5147 5355 143 LI:198782.4:2000SEP0881192667 5201 5355 143 LI:198782.4:2000SEP088783039 5202 5354 143 ~ LI;198782.4:2000SEP0881481930 5240 ~ 5356 143 LI:198782.4:2000SEP088.6567865 5252 5354 143 LI:198782.4;2000SEP082129634H1 5300 5354 144 LI;2030279.1:2000SEP0884124200 1540 1885 144 LI:2030279.1;2000SEP0885664544 1561 1885 144 LI;2030279.1:2000SEP0885678269 1426 1885 144 LI:2030279.1:2000SEP084097504F8 121 b 1756 144 LI;2030279.1:2000SEP084097583H1 1206 1368 144 LI;2030279.1:2000SEP088819125 993 1354 144 LI;2030279.1;2000SEP088847513 998 1344 144 LI:2030279.1;2000SEP088894561 1133 1326 144 LI:2030279.1:2000SEP08239737076 1127 1322 144 LI;2030279.1:2000SEP088847512 711 1034 144 LI:2030279.1;2000SEP088894605 7 i 1 972 144 LI:2030279. 7 8819124 711 949 ;2000SEP08 144 LI:2030279.1:2000SEP088969809 414 815 144 LI:2030279.1;2000SEP084958864H1 676 810 144 LI:2030279.1:2000SEP087702090H1 686 767 144 LI:2030279.1;2000SEP082397370H1 664 767 144 LI;2030279.1:2000SEP082397370F6 664 767 144 LI:2030279.1;2000SEP083048139H 1 658 767 144 LI:2030279.1:2000SEP088888757 395 681 144 LI:2030279.1:2000SEP088734030 136 566 144 LI;2030279.1;2000SEP088791917 i 81 465 144 LI:2030279.1:2000SEP08g 1013278 223 447 144 LI:2030279.1;2000SEP088838950 1 336 SEQ ID Template ID Component Start Stop NO: ID

144 LI:2030279,1:2000SEP08g6989913 T 648 1887 144 LI:2030279.1:2000SEP08g3752364 1454 1886 145 LI:1 Ol 8424.3:2000SEP0871223752V 1083 1652 145 LI:1018424.3:2000SEP085781891 F6 685 1177 145 LI:1018424.3:2000SEP085781891 H1 685 934 145 LI:1018424.3:2000SEP0871222903V1 685 1288 145 LI:1018424,3:2000SEP083719168H1 933 1218 145 LI:1018424,3:2000SEP0837191 i58Fb 933 1403 145 LI:1018424.3:2000SEP0871223803V1 1083 1500 145 LI:1 Ol 8424.3:2000SEP0871223901 676 1359 i 45 LI:1018424.3:2000SEP087694804) 276 646 145 LI:1018424,3:2000SEP087639804H2 391 989 145 LI:10~18424,3:2000SEP087711179H1 474 935 145 LI:1018424.3:2000SEP085946909H1 480 802 145 LI:1018424,3:2000SEP086857771H1 537 1017 145 LI:1018424.3:2000SEP087383248H 64 468 145 LI:1018424.3:2000SEP087639804)2 b9 684 145 LI:1018424,3:2000SEP087226703H1 156 662 145 LI: T O 18424.3:2000SEP087222639H 1 482 145 LI:1018424.3:2000SEP0870842868V1 1118 1795 i 46 Ll: 7 30969,1:2000SEP084344164H 1895 1989 146 LI:130969.1:2000SEP086470643H1 1967 2601 146 LI:130969.1:2000SEP087720888) 2002 2357 146 LI:130969,1:2000SEP087579533H 2179 2762 146 LI:1309b9.1:2000SEP084874203H 2227 2497 146 LI:1309b9,1:2000SEP081506715H 2251 2520 146 LI:130969.1:2000SEP085334709F8 2355 2918 146 LI:130969.1:2000SEP085334709F6 2355 2643 146 LI:130969,1:2000SEP08524905H 1 467 716 146 LI:130969.1:2000SEP081871804H1 196 450 146 LI:1309b9.1:20DOSEP083661732F8 334 916 146 LI:130969,1:2000SEP087725180) 303 866 146 LI:130969.1:2000SEP08526216H 1 466 714 146 LI:130969,1:2000SEP083661732T8 1 487 146 LI:130969,1:2000SEP08g5544854 153 315 146 LI:1309b9.1:2000SEP087725592H1 720 1367 146 LI:130969,1:2000SEP087318481 H 683 1244 i 46 LI:130969.1:2000SEP086357 i 21 659 800 146 LI:130969.1:2000SEP087660892) 625 1053 146 LI:130969.1:2000SEP083661732H1 633 916 146 LI:130969,1:2000SEP081657839H 583 694 146 LI:130969.1:2000SEP087000424F8 620 1198 146 LI:130969.1:2000SEP08700042488 620 ~ 1198 146 LI:130969.1:2000SEP083788096H 921 1040 146 LI:130969.1:2000SEP087720888H 1092 1679 146 LI:130969,1:2000SEP087000424H 1137 1198 146 LI:130969.1:2000SEP088034483) 1261 1800 146 LI:130969.1:2000SEP087718653) 1555 2210 SEQ ID Template ID Component Start Stop NO; ID

146 LI:1309b9.1;2000SEP087986828H1 ' 1661 2270 146 LI:130969.1:2000SEP087660868H1 1881 2490 146 LI:130969.1:2000SEP083460547H1 2469 2660 146 LI:1309b9.1:2000SEP085334709H 1 2355 2553 146 LI:1309b9.1;2000SEP084874203F7 2426 2760 146 LI:130969.1:2000SEP087726534H 1 737 1285 147 LI;286246.2;2000SEP0871537829V1 735 1233 147 LI:286246.2;2000SEP0870562337V1 1821 2410 147 LI:28b246.2:2000SEP0870843114V1 1565 1808 147 LI;286246.2;2000SEP0871553959V1 2070 2421 147 LI;286246.2:2000SEP0871670404V1 1621 1920 147 LI:28b246.2:2000SEP086152650H 1 2579 2710 147 LI:286246.2:2000SEP081941561H1 2459 2705 147 LI;286246.2:2000SEP0871539112V1 2393 2710 147 LI:28b246.2:2000SEP08003298H 1 2088 2574 147 LI:286246.2:2000SEP0871539117V1 943 1334 147 LI;28b246.2:2000SEP0871045845V1 744 1329 147 LI;28b246.2:2000SEP0871542189V1 1171 1330 147 LI;286246.2;2000SEP0871540655V1 1503 1889 147 LI;28b246.2:2000SEP08753064H1 207 446 147 LI;28b246.2:2000SEP0871554818V1 207 383 147 LI;286246.2;2000SEP084835102H1 70 336 147 LI:286246.2;2000SEP0871543193V1 1373 1761 147 LI:286246.2:2000SEP0871243325V1 1621 1745 147 LI:28b246.2:2000SEP08~ 71540358V1 1706 2207 147 LI:286246.2;2000SEP0870555497V1 1585 2205 147 LI:286246.2:2000SEP0870561143V1 1554 2200 147 LI:28b246.2;2000SEP0871223039V1 1822 1907 147 LI;286246.2;2000SEP0871047689V1 1555 1882 147 LI;286246.2;2000SEP0870561457V1 1427 1720 147 LI;286246.2:2000SEP0871047089V1 1228 1721 147 LI:286246.2;2000SEP0871537608V1 1390 1702 147 LI;286246.2;2000SEP0871246060V1 1629 1702 147 LI;28b246.2;2000SEP0870560146V1 1189 1696 147 LI:28b246.2:2000SEP0871539205V1 1022 1693 147 LI:286246.2;2000SEP0871538958V1 2000 2460 147 LI:28b246.2:2000SEP0870560255V1 1725 1868 147 LI:28b246.2;2000SEP0870561356V1 1408 1867 147 LI:286246.2:2000SEP0871537611V1 1540 1982 147 LI:286246.2;2000SEP0870561842V1 1369 1979 147 LI:28b246.2:2000SEP0871048263V 1221 1950 147 LI:28b246.2;2000SEP0871539434V1 1382 2023 147 LI:28b246.2;2000SEP087123394H1 214 510 147 LI:28b246.2;2000SEP0871045783V1 744 1431 147 LI:286246.2:2000SEP0871051139V1 1724 1913 147 LI;286246.2;2000SEP0871048786V1 1675 2130 147 LI:286246.2:2000SEP0871048066V1 1546 2112 147 LI:28b246.2;2000SEP0870561666V1 1586 2142 IgJ

SEQ ID Template ID Component Start Stop NO: ID

147 LI;286246.2;2000SEP0870560120V1 1459 2096 147 LI:286246.2;2000SEP086274047H1 1495 2090 147 , LI:286246.2;2000SEP0871243756V1 1484 2083 147 LI;286246.2:2000SEP0870561769V1 1533 2141 147 LI:286246.2:2000SEP0871242738V1 1454 2082 147 LI:286246.2;2000SEP0871046929V1 1546 2082 147 LI:286246.2;2000SEP0871243123V1 1443 2078 147 LI:286246.2:2000SEP0871046075V1 1371 2078 147 LI:28b246.2;2000SEP0871054743V1 1868 2071 147 LI:286246.2;2000SEP0871540043V1 1860 2061 147 LI:28b246.2:2000SEP0871540268V1 1327 2060 147 LI:28b246.2;2000SEP0870560467V1 1377 2056 147 LI;28b246.2;2000SEP0871245530V1 2527 2710 147 LI:286246.2:2000SEP0871539404V1 2136 2589 147 LI;28b246.2;2000SEP0871539423V1 2109 2598 147 LI:286246.2;2000SEP08500290279 1992 2587 147 LI:28b246.2:2000SEP0871045716V1 2154 2520 147 LI:28b246.2;2000SEP0871540558V1 860 1321 147 LI:286246.2:2000SEP0871047312V1 2085 2710 147 LI:28b246.2;2000SEP086206414H1 2071 2710 147 LI:28b246.2;2000SEP0871553195V1 1028 1389 147 LI:286246.2:2000SEP0871538629V1 1373 1761 147 LI:28b246.2:2000SEP0871542943V1 1319 1759 147 LI:286246.2;2000SEP0871540253V1 792 1532 147 LI;286246.2;2000SEP0871045637V1 1129 1490 147 LI:28b246.2:2000SEP086271029H2 965 1523 147 LI:28b246.2:2000SEP0870555132V1 922 1520 147 LI:28b246.2;2000SEP0871542566V1 937 1475 147 LI:28b246.2:2000SEP0871242763V1 744 1465 147 LI;286246.2;2000SEP0871244412V1 1129 1454 147 LI:28b246.2:2000SEP0871544889V1 978 1451 147 LI:28b246.2;2000SEP0871538305V1 1111 1452 147 LI:28b246.2:2000SEP0871540285V1 1147 1592 147 LI:286246.2:2000SEP0871540983V1 1083 1593 147 LI:286246.2;2000SEP0871542737V1 1036 1565 147 LI:28b246.2;2000SEP086743680Ni 10i6 1567 147 LI:28b246.2;2000SEP0870559871 Vl 1258 1644 147 LI:28b246.2;2000SEP087123394F8 219 510 147 LI:286246.2:2000SEP087585860H2 1 633 147 LI;286246.2:2000SEP0871244615V1 1676 1872 147 LI:28b246.2;2000SEP0871540204V1 .1382 1632 147 LI:286246.2:2000SEP084122893H1 1970 2202 147 LI;286246.2;2000SEP0871046145V1 1579 2193 147 LI:28b246.2:2000SEP0871052465V1 1753 1913 147 LI;286246.2;2000SEP0871541476V1 1379 1920 147 LI:286246.2:2000SEP0871040490V1 1135 1220 147 LI:286246.2:2000SEP085680372F6 744 1136 147 LI:28b246.2:2000SEP0871545686V1 1545 1883 SEQ ID Template ID Component ' Start Stop NO: ID

147 LI:286246,2:2000SEP0871244339V1 1203 1881 147 LI:286246,2:2000SEP08194156176 2455 267i 147 LI:286246.2:2000SEP0870843645V1 1609 2162 147 LI:28b246,2:2000SEP0871047111V1 1484 2145 147 LI:28b246,2:2000SEP0871244003V1 1235 1796 147 LI:286246.2:2000SEP08g672529 1426 1778 147 LI:28b246,2:2000SEP0870559901 V 1225 1773 147 LI:286246,2:2000SEP0871044921 V1 1336 1761 147 LI:286246.2:2000SEP0871047834V1 2048 2689 147 LI:28b246,2:2000SEP0871045886V1 1259 1848 147 LI:286246,2:2000SEP0871048727V1 1512 1832 147 LI:286246.2:2000SEP0871543038V1 7341 1839 147 LI:286246,2:2000SEP0871048663V1 1283 1821 147 LI:286246,2:2000SEP0870560339V1 1148 1819 147 LI:28b246.2:2000SEP0870561925V1 1988 2388 147 LI:28b246,2:2000SEP0871047478V1 1343 1864 147 LI:286246.2:2000SEP0871539466V1 1138 1866 147 LI:286246,2:2000SEP0871545826V1 1471 1687 147 LI:28b246,2:2000SEP0871540331 V1 931 1667 147 LI:28b246.2:2000SEP0871044926V1 1191 1666 147 LI:28b246,2:2000SEP0871540192V1 1155 1657 147 LI:28b246,2:2000SEP0871242808V1 2120 2727 147 LI:286246.2:2000SEP0871047724V1 2122 2729 147 LI:286246.2:2000SEP0871047489V1 2234 2712 147 LI:28b246,2:2000SEP0871047868V1 2067 2727 147 LI:286246.2:2000SEP0870449628V1 782 1120 147 ~ LI:28b246,2:2000SEP08500290278 1961 2586 147 LI:286246.2:2000SEP08g2410095 2232 2356 147 LI:28b246.2:2000SEP0870555842V1 1640 2314 147 LI:286246.2:2000SEP0871243779V1 1729 2294 147 LI:286246.2:2000SEP0871047027V1 1654 2270 147 L1:286246.2:2000SEP0871048396V1 1229 1882 147 LI:286246,2:2000SEP0871054331 Vl 1388 1889 147 LI:28b246.2:2000SEP0871542747V1 807 1290 147 LI:28b246.2;2000SEP0871542294V1 564 1304 147 LI:28b246,2:2000SEP0871542526V1 535 1289 147 LI:286246.2:2000SEP087 i 538262Vi 973 1289 147 LI:286246,2:2000SEP08g2880816 2281 2711 147 LI:28b246.2:2000SEP0871244177V1 2001 2710 147 LI:286246.2:2000SEP0871243630V1 2085 2710 147 LI:286246.2:2000SEP087192911 H2 2144 2715 147 LI:28b246,2:2000SEP085957753H1 927 1541 147 LI:286246.2:2000SEP0871539504V1 1039 1564 147 LI:28b246.2:2000SEP0871045343V1 1326 1723 147 LI:28b246,2:2000SEP0871044936V1 1104 1722 147 LI:28b246.2:2000SEP0871537853V1 1830 2259 147 LI:28b246,2:2000SEP0870560372V1 1957 2257 147 LI:28b246.2:2000SEP0871042212V1 1897 2252 _ .

1g5 SEQ ID Template ID Component Start Stop NO: ID

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147 LI:28b246.2;2000SEP0871553295V1 1028 1389 147 LI;286246.2:2000SEP0871553334V1 1028 1389 147 LI:28b246.2;2000SEP0871543267V1 1026 1352 147 LI;286246.2:2000SEP0871541778V1 2535 2710 147 LI:286246.2;2000SEP08i941561Rb 2455 2710 147 LI:28b246.2:2000SEP086340283H 1 2219 2710 147 LI:28b246.2:2000SEP08g6991789 2229 2710 147 LI:286246.2:2000SEP0871541225V1 2234 2710 147 LI:286246.2:2000SEP0871547092V1 2240 2366 147 LI;286246.2;2000SEP0871540847V1 2178 2384 147 LI;286246.2:2000SEP0871048693V1 1989 2700 147 LI:28b246.2;2000SEP0871541749V1 735 1261 147 LI:286246.2;2000SEP0871542963V1 1274 1834 147 LI;286246.2:2000SEP0871538861 V1 1834 2598 i47 LI:28b246.2;2000SEP087i539143Vi 1976 2460 147 LI;286246.2:2000SEP0871553879V1 2141 2478 147 LI:28b246.2:2000SEP0871044960V1 1787 2460 148 LI:001527.1:2000SEP08g5877753 987 1301 148 LI:001527.1;2000SEP08g6657300 1129 1301 148 LI:001527.1:2000SEP086341247H1 908 1301 148 LI;001527.1:2000SEP083409462F6 910 1301 148 LI:001527.1:2000SEP083409462H 1 910 11 b4 148 LI;001527.1:2000SEP0871548338V1 151 847 148 LI:001527.1;2000SEP0871548312V1 154 817 148 LI:001527.1:2000SEP084698934H1 504 763 148 LI:001527.1:2000SEP087735666H i 506 1 i 148 LI;001527.1:2000SEP087691689H2 679 1235 148 LI:001527.1;2000SEP08g3961333 791 1162 148 LI:001527.1;2000SEP08798740H1 1 246 148 LI:001527.1;2000SEP084041891 H 13 309 148 LI:001527.1:2000SEP086778992H1 15 534 148 LI:001527.1:2000SEP0871549018V 36 631 148 LI:001527.1:2000SEP083044046F6 36 406 148 LI:001527.1:2000SEP083044046H1 36 286 148 LI:001527.1;2000SEP087925481 H 36 179 148 LI:001527.1:2000SEP086778992F8 60 637 148 LI:001527.1:2000SEP08g2063121 60 410 149 LI;395063.1:2000SEP087093763H1 1378 1781 149 LI:395063.1;2000SEP087093324F8 1378 1781 149 LI;395063.1:2000SEP087093763F8 1398 1781 149 LI:395063.1;2000SEP0870678552V1 1438 2018 i 49 LI;395063.1:2000SEP0870669601 V i 453 T 679 i 149 LI;395063.1:2000SEP0870672059V1 1296 1514 149 LI:3950b3.1:2000SEP0870647192V1 1368 2058 149 LI:3950b3.1;2000SEP0870676346V1 1375 2026 149 LI:3950b3.1:2000SEP08573252678 1151 1651 149 LI;3950b3.1:2000SEP081426382H1 1240 1516 149 LI:3950b3.1:2000SEP085732526H1 1047 1322 SEQ ID Template ID ~ Component Start Stop NO: ID

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154 LI:474108,2:2000SEP087249758H2 1398 1959 154 LI:474108.2:2000SEP081834781 T6 4060 4377 154 LI:474108,2:2000SEP083713858H1 2615 2730 154 LI:474108.2:2000SEP08g7316893 2626 3079 154 LI:474108.2:2000SEP084711425H1 2494 2750 154 LI:474108,2:2000SEP085331713H1 2528 2793 154 LI:474108.2:2000SEP085181291 H 4642 4870 154 LI:474108.2:2000SEP085680433H1 2824 3088 154 LI:474108.2:2000SEP085680401 H 2826 3023 154 L1:474108.2:2000SEP086709569J 1 4414 4866 154 LI:474108.2:2000SEP08g5108937 4444 4867 154 LI:474108,2:2000SEP08g1193841 3977 4169 154 LI:474108.2:2000SEP08g3418917 4035 4414 154 LI:474108.2:2000SEP08g3539298 4035 4422 154 LI:474108,2:2000SEP08gi 190912 4653 4862 154 LI:474108.2:2000SEP085369964H 1 4314 4579 154 LI:474108,2:2000SEP085369955H1 4314 4582 154 LI:474108.2:2000SEP08g 1980043 4321 4601 154 LI:474108.2:2000SEP085388940H1 2032 2286 154 LI:474i08.2:2000SEP087087904H1 1 387 154 LI:474108.2:2000SEP083078492H 1 28 314 154 LI:474108.2:2000SEP087984912H1 31 586 154 LI:474108.2:2000SEP08g2220897 313 700 154 LI:474108,2:2000SEP083317408F6 4444 4863 154 LI:474108.2:2000SEP083317408H 1 4444 4693 154 LI:474108,2:2000SEP084177811 F6 4843 5390 155 LI:230711,2:2000SEP0871594734V1 109 686 155 LI:230711.2:2000SEP0871592650V1 1006 1701 155 LI:230711,2:2000SEP0871596872V1 311 1046 155 LI:230711.2:2000SEP0871596548V1 219 775 155 LI:230711.2:2000SEP0871596601 V 277 928 155 LI:230711.2:2000SEP0871592649V 296 946 155 LI:230711.2;2000SEP0870682403V1 309 861 155 LI:230711,2:2000SEP0870683980V1 309 835 155 LI:230711.2:2000SEP083925359H 1 309 620 155 LI:230711.2:2000SEP083925359F6 309 494 155 LI:230711,2:2000SEP0870682278V1 309 475 155 L1:230711.2:2000SEP08g387128 i i 648 2103 155 LI:230711.2:2000SEP08g5340629 1655 2055 155 LI:230711,2:2000SEP08g5441107 1659 2114 155 LI:230711.2:2000SEP08g6662367 1663 2126 155 LI:230711,2:2000SEP08g2934374 1667 2114 155 LI:230711.2:2000SEP08g7317140 1690 2126 155 LI:230711.2:2000SEP08g5055123 1692 2103 155 LI:230711,2:2000SEP081431377H1 1817 2063 155 LI:230711.2:2000SEP08g3047856 1835 2117 155 LI:230711.2:2000SEP08g4371425 1850 2114 155 LI:230711.2:2000SEP087127851 T8 1872 1932 SEQ ID Template ID Component Start Stop NO: ID

155 LI;230711.2:2000SEP0870686041 V 1877 2038 155 LI:230711.2;2000SEP08g4327870 1893 2114 155 LI:230711,2:2000SEP08g3134381 1893 2114 155 LI:230711.2:2000SEP0871597167V1 341 1092 155 LI:230711,2;2000SEP083531535H1 364 703 155 LI;230711.2:2000SEP0871591783V1 421 1023 155 LI:230711.2;2000SEP0871596281 V1 440 1017 155 L1:230711.2;2000SEP087125750F8 26 563 155 LI;230711.2:2000SEP086452362F8 1 542 155 LI:230711.2;2000SEP0871591870V1 838 1445 155 L1:230711,2:2000SEP0871592920V1 876 1542 155 LI:230711.2:2000SEP0871591585V1 927 1619 155 LI:230711,2:2000SEP0870680431 V1 466 952 155 LI;230711.2:2000SEP0871594480V1 477 1181 155 LI:230711.2:2000SEP0871597256V1 525 1152 155 LI.230711.2:2000SEP0870683177V1 1071 1594 155 LI:230711.2;2000SEP0871592455V1 463 1113 155 LI:230711,2;2000SEP0871592682V1 806 1413 ' 155 LI;230711.2:2000SEP0870708067V1 795 900 155 L1:230711.2:2000SEP0871596835V 824 1530 155 LI;230711,2:2000SEP084071965F6 29 403 155 , L1:230711.2:2000SEP0871592539V1 29 ~ 491 155 LI:230711.2;2000SEP084071965H1 29 335 155 L1;230711,2:2000SEP0870680197V1 1076 1454 155 LI:230711,2;2000SEP0871592442V1 1074 1767 155 LI;230711,2:2000SEP0871594276V1 1077 1824 155 LI:230711.2;2000SEP0871592619V1 1082 1771 155 LI;230711,2;2000SEP0871596528V1 1125 1881 155 LI:230711,2:2000SEP0871592914V1 1085 1786 155 LI:230711.2;2000SEP0871621181V1 1136 1668 155 LI;230711,2;2000SEP08~71597169V1 1146 1756 155 LI;230711,2:20bOSEP0871595423V1 1151 1772 155 LI:230711.2;2000SEP0871592214V1 1182 1807 155 LI;230711.2:2000SEP0871592569V1 1103 1855 155 LI:230711.2;2000SEP0871595077V1 1105 1746 155 LI:230711.2;2000SEP0871594784V1 1118 1930 155 LI;230711,2;2000SEP0870679832V1 1205 1830 155 L1;230711.2:2000SEP0870681040V1 1227 1834 155 LI:230711.2:2000SEP087282455H 1 1240 1845 155 LI:230711.2:2000SEP0871593068V1 1259 1927 155 LI;230711.2:2000SEP0870684191V1 1265 1406 155 LI:230711.2:2000SEP0871592819V1 1296 1986 155 LI;230711.2;2000SEP0871593883V1 1295 1956 155 LI:230711.2:2000SEP0871591755V1 1305 2015 155 LI:230711.2;2000SEP0871597148V1 1307 2018 155 LI;230711,2:2000SEP0870687607V1 1325 1749 155 L1:230711.2:2000SEP0871596350V 1330 1607 155 LI:230711.2:2000SEP0871597474V1 1345 2092 SEQ ID Template ID Component Start Stop NO: ID

155 LI;230711.2;2000SEP0871595132V1 1353 1876 155 LI:230711.2:2000SEP0871593826V1 1357 2068 155 LI:230711.2:2000SEP0870680047V1 1347 2005 155 LI:230711.2:2000SEP0870679818V1 1374 2074 155 LI:230711.2:2000SEP0871595653V1 1385 1998 155 LI:230711.2:2000SEP086543969H 1 1385 1970 155 LI:230711.2:2000SEP084378643F7 1431 2051 155 LI:230711.2;2000SEP084379312F7 1431 1981 155 LI:230711.2:2000SEP084379312H1 1431 1723 155 LI:230711.2:2000SEP084378643H1 1432 1734 155 LI;230711.2;2000SEP0870682506V1 1450 2057 155 LI:230711.2:2000SEP086623832H 1 1450 i 969 155 LI:230711.2;2000SEP0870708640V1 1508 1735 155 LI:230711.2;2000SEP08392535976 1523 2082 155 LI:230711.2;2000SEP08510083979 1546 1866 155 LI:230711.2:2000SEP08437864377 1577 2010 155 LI:230711.2:2000SEP0870682 7 05V 1579 2114 155 LI:230711.2:2000SEP08407196576 1600 2121 155 LI:230711.2:2000SEP0871592368V1 1622 2113 155 LI:230711.2:2000SEP08532801276 1625 2076 155 LI;230711.2;2000SEP085328012F6 1632 2035 155 LI:230711.2:2000SEP085328012H1 1632 1889 155 LI:230711.2:2000SEP087127851 F8 35 683 155 LI;23071 i.2:2000SEP087125750H7 27 439 155 LI:230711.2:2000SEP083699779H 1 539 719 155 LI:230711.2;2000SEP0871596494V1 632 1324 155 LI:230711.2:2000SEP0871595289V1 640 1334 155 LI:230711.2:2000SEP0870681329V1 793 964 155 LI:23071 i .2:2000SEP0871593141 V 646 i 271 i 155 LI;230711.2:2000SEP0871594054V1 661 1250 I

155 LI:230711.2:2000SEP0871597118V1 705 1453 155 LI:230711.2;2000SEP0871592473V1 737 1471 155 LI:230711.2:2000SEP0871595446V1 451 1104 155 LI:230711.2:2000SEP0871597018V1 960 1687 155 LI:230711.2:2000SEP0871597402V1 968 1539 155 LI:230711.2:2000SEP0871596514V1 990 1501 i55 LI;230711.2;2000SEP087159i665V1 29 607 156 LI:008942.1:2000SEP086948684F8 1535 1965 156 LI:008942.1:2000SEP086948684H 1 1535 1758 156 LI:008942.1:2000SEP087281566H1 28 439 156 LI;008942.1:2000SEP087952051 H2 25 700 156 LI:008942.1;2000SEP08729055888 39 692 156 LI:008942.1;2000SEP082505107H1 53 157 156 LI:008942.1:2000SEP088116885H1 4 654 156 LI:008942.1;2000SEP087999428H1 38 663 156 LI;008942.1:2000SEP082779147H1 76 348 156 LI:008942.1:2000SEP08g2825239 90 271 156 LI:008942.1:2000SEP087 i 00462H 127 544 __ __ - _-_.

SEQ ID Template ID Component Start Stop NO: ID

156 LI:008942.1:2000SEP087997486H1 260 901 156 LI:008942,1:2000SEP086376692H1 1237 1428 156 LI:008942.1:2000SEP0870332069D1 11 b9 1428 156 L1:008942.1:2000SEP0870330927D1 1283 1776 156 LI:008942.1:2000SEP0870309464D 1233 1434 156 LI:008942,1:2000SEP0870311281 D1 1283 1798 156 LI:008942,1:2000SEP0870331388D1 1157 1428 156 LI:008942.1:2000SEP0870728082V1 1160 1425 156 LI:008942,1:2000SEP0870310348D1 1358 1803 156 LI:008942,1:2000SEP087966746H 1 1531 2090 156 L1:008942.1:2000SEP082369660H 1 1175 1414 156 LI:008942,1:2000SEP0870330650D1 1231 1426 156 LI:008942,1:2000SEP0870727843V 1175 1427 156 LI:008942.1:2000SEP082372577H1 1175 1423 156 LI:008942.1:2000SEP0870729702V1 1175 1414 156 LI:008942,1:2000SEP0870731634V1 1175 1427 156 LI:008942,1:2000SEP0870801702V 1175 1424 156 LI:008942.1:2000SEP0870729964V1 1175 1427 156 LI:008942.1:2000SEP082369660F6 1175 1428 156 LI:008942.1:2000SEP082372577F6 1175 1428 156 LI:008942.1:2000SEP087700714H1 1820 2410 156 LI:008942,1:2000SEP08'70311066D1 1158 1427 156 LI:008942.1:2000SEP0870730649V 1168 1428 156 LI:008942,1:2000SEP0870310381 D1 1169 1349 156 LI:008942.1:2000SEP0870310610D1 1251 1427 156 LI:008942,1:2000SEP082827340H2 68 362 156 LI:008942.1:2000SEP086918520H1 696 1194 156 Ll:008942,1:2000SEP081423821 Tb 940 1409 156 LI:008942,1:2000SEP087700714) 1 1108 1637 156 LI:008942.1:2000SEP087987293H1 1 572 157 LI:732479. ) :2000SEP086987581 H 1420 1724 157 LI:732479.1:2000SEP087006122H1 1551 1748 157 LI:732479.1:2000SEP081314671 Tb 1 360 157 LI:732479,1:2000SEP081314671 F6 8 398 157 LI:732479,1:2000SEP081314671 H 8 235 157 LI:732479,1:2000SEP08g1966425 56 531 157 LI:732479,1:2000SEP08g6993126 125 538 157 LI:732479.1:2000SEP08g2063478 170 406 157 LI:732479.1:2000SEP085453575H1 276 518 157 LI:732479.1:2000SEP087015239H 1 397 976 157 LI:732479.1:2000SEP086167048F8 798 1309 157 LI:732479.1:2000SEP083727038H1 530 818 157 LI:732479.1:2000SEP088006617H1 498 1153 157 LI:732479.1:2000SEP083727038F9 530 1069 157 LI:732479,1:2000SEP086167048H 1 980 1310 157 LI:732479.1:2000SEP087077449H 1 1214 1706 157 LI:732479,1:2000SEP081434378H 1 1291 1439 157 LI:732479.1:2000SEP086940364H7 869 1396 SEQ ID Template ID Component Starf Stop NO: ID

157 LI:732479.1:2000SEP088112243H1 1 314 157 LI;732479.1:2000SEP087094636H1 789 1287 158 LI;1190250.1:2000SEP086779840H1 9 551 158 LI;1190250.1:2000SEP083386816H 1 1 185 158 LI:1190250.1:2000SEP083888124H 1 4 270 158 LI:1190250.1:2000SEP0870817678V1 294 831 158 LI:1190250,1;2000SEP08195134976 298 805 158 LI:1190250,1;2000SEP086947424H1 304 817 158 LI:1190250.1:2000SEP08g5054158 306 793 158 LI:1190250,1:2000SEP081658838H1 309 541 158 LI:1190250,1:2000SEP0870819393V 180 693 158 LI:1190250.1:2000SEP083002522F6 180 469 158 LI:1190250.1:2000SEP0871218340V1 181 693 158 LI:1190250.1;2000SEP083002522H1 181 ~ 492 158 LI:1190250,1:2000SEP0871218644V 202 417 158 LI:1190250,1;2000SEP08720361888 247 938 158 LI:1190250.1:2000SEP08g895347 1 84 158 LI:1190250,1:2000SEP08' 4005442F6 1 328 158 LI:1190250.1:200DSEP08338681 bFb 1 625 158 LI:1190250.1:2000SEP084005442H1 2 287 158 LI:1190250,1;2000SEP087946358H 1 14 762 158 LI:1190250, 7 6250084H 1 67 596 ; 2000SEP08 158 LI:1190250,1:2000SEP082809974H 1 67 326 158 LI:1190250,1;2000SEP087607592H1 68 bbb i 58 LI;1190250.1:2000SEP083159561 H 58 222 158 LI:1190250.1:2000SEP08412478H1 375 603 158 LI:1190250. 7 2862291 H1 377 656 ;2000SEP08 158 Li:1190250.1;2000SEP08g3934153 378 847 158 LI:1190250,1;2000SEP08g3900180 406 846 i58 LI:1190250.1:2000SEP08391612F1 434 1065 158 LI:1190250,1:2000SEP088040158H 1 442 1055 158 LI:1190250.1:2000SEP08509350H1 107 309 158 LI:1190250.1:2000SEP087946358J2 99 722 158 LI;1190250.1;2000SEP0870821132V1 180 735 158 LI:1190250.1;2000SEP0870822288V1 180 737 158 LI:1190250.1:2000SEP0870818910V1 180 735 158 LI:1190250.1;2000SEP082929935H1 184 470 158 LI:1190250.1:2000SEP082929935F6 184 426 158 LI:1190250.1;2000SEP0870832705V1 719 828 158 LI:1190250.1:2000SEP0841247876 841 1021 158 LI;1190250.1;2000SEP086779840J1 900 1328 158 LI:1190250.1:2000SEP08g2631213 993 1063 158 LI:1190250.1:2000SEP085501816F6 1067 1306 158 LI:1190250.1;2000SEP08550181 bHl 1122 1225 158 LI;1190250.1:2000SEP0855024037H1 471 1049 158 LI:1190250.1:2000SEP08400544276 489 1016 158 LI:1190250.1;2000SEP0870818940V1 508 1082 158 LI;1190250,1:2000SEP0855_024037) 552 1217 _ ._ 1 SEQ ID Template ID Component Start Stop NO; ID

158 LI:1190250.1:2000SEP08g5339250 562 1047 158 LI:1190250.1;2000SEP08059074H1 604 769 158 LI:1190250.1;2000SEP0870821167V1 631 1080 158 LI:1190250.1:2000SEP0870822737V1 647 955 158 LI:1190250.1:2000SEP088040158) 1 693 1219 158 LI:1190250.1:2000SEP083672749H 1 81 366 158 L1:1190250.1:2000SEP08653157H 1 82 3 i 158 LI:1190250.1;2000SEP08g3000968 312 608 158 LI:1190250.1:2000SEP08338681676 339 821 158 LI;1190250.1:2000SEP0839161281 355 904 158 LI:1190250.1:2000SEP0841247886 375 703 159 LI;1013717.1:2000SEP086798057F8 1 566 159 LI:1013717.1:2000SEP086798057H1 1 529 159 Lt: i Oi 3717.1;2000SEP08679805778 490 1066 i 60 LI:2049125.2:2000SEP0852918 i 8H i 259 i 160 LI;2049125.2:2000SEP0870803952V1 1 661 160 LI:2049125.2:2000SEP085542143H1 81 171 160 LI;2049125.2:2000SEP0870801203V1 73 267 T 60 LI:2049125.2;2000SEP086969152U 1 45 453 161 LI:10923b0.1:2000SEP086752529) 1 258 791 161 LI:10923b0.1:2000SEP08675252988 213 791 1 6l LI;10923b0.1:2000SEP086881093F8 1 605 161 LI:1092360.1:2000SEP08g3597108 494 810 161 LI:10923b0.1:2000SEP08g5364506 349 799 161 LI:10923b0.1:2000SEP08g5590217 452 908 161 LI:1092360.1:2000SEP086881093H1 125 605 1 b2 LI:791524.1:2000SEP082998325H 1 148 431 1 b2 LI:791524.1:2000SEP088050221 H 68 671 1 b2 LI:791524.1:2000SEP08299832576 141 606 1 b2 LI:791524. i ; 7752481 H 1 576 ~ 2000SEP08 7 1 b2 LI;791524.1:2000SEP082998325F6 148 570 162 LI:791524.1;2000SEP08g5664125 340 652 1 b3 LI:1084555.3:2000SEP08g2004742 235 515 1 b3 LI:1084555.3:2000SEP086457442H 1 1 511 1 b3 LI:1084555.3:2000SEP086452042H 1 1 566 1 b3 LI:1084555.3:2000SEP084053081 H 103 373 i 64 LI;815418.2:2000SEP081939605H 1 1643 i 921 1 b4 LI:815418.2:2000SEP086079908H 1 1858 2307 164 LI;815418.2:2000SEP088097467H1 9 637 1b4 LI:815418.2;2000SEP087019587H1 2 481 164 LI:815418,2;2000SEP087696123)1 5 371 164 LI:815418.2:2000SEP0871592951 V1 1443 2126 1 b4 LI:815418.2:2000SEP087720648) 1 594 1173 164 LI;815418.2:2000SEP083524549H1 1247 1373 164 LI;815418.2:2000SEP081404445H1 1256 1526 1 b4 LI:815418.2:2000SEP087700830H 1 377 932 1 b4 LI:815418.2:2000SEP087646833H 1 381 1075 164 LI:815418.2;2000SEP087704184H1 379 1038 SEQ ID NO: Template ID Component Start Stop ID

164 LI:815418.2:2000SEP087758306) 1 400 1075 164 LI:815418.2;2000SEP087959989)1 412 1048 164 LI:815418.2;2000SEP08829930H1 1411 1558 1 b4 LI;8 T 5418.2:2000SEP087726033H 1 ' 25 680 164 LI:815418.2:2000SEF087704184) 1 63 656 164 LI:815418.2:2000SEP0871591834V1 1746 2196 164 LI:815418.2:2000SEP085461482H 1 1 243 164 LI:815418.2;2000SEP085513865H1 1 224 164 LI;815418.2:2000SEP085116934H1 1082 1337 164 LI:815418.2:2000SEP087357218H T 1493 1688 164 LI:815418.2:2000SEP0871596065V 1758 2200 164 LI:8 T 5418.2:2000SEP087088412H 1 1733 2038 164 LI;815418.2:2000SEP084111224H1 1247 1495 T 64 LI:8154 T 8.2;2000SEP085440737H 1 T 27 T 1391 164 LI:815418.2:2000SEP087757516) 1 1279 1803 164 LI;8154i8.2:2000SEP083805239H1 1279 1543 1b4 LI;815418.2:2000SEP084432282H1 1279 1532 164 LI:815418.2;2000SEP085119476H1 1279 1528 1b4 LI:815418.2:2000SEP083327962H1 1279 1504 1 b4 LI; 8 T 5418.2;2000SEP085950033H 1 1279 1482 164 LI;815418,2:2000SEP081831675H1 1283 1612 164 LI;815418.2;2000SEP084551031H1 1293 1551 164 LI:815418.2:2000SEP086937361 H1 1279 1819 164 LI;815418.2:2000SEP087726033) T T 289 1929 164 LI:815418.2:2000SEP081638772H1 1292 1527 1 b4 LI:8 T 54 T 8.2; T 638676H 1292 1430 164 LI:815418.2:2000SEP083356985H1 1295 1602 164 LI;815418.2:2000SEP08g2028647 1297 1559 164 LI;815418.2;2000SEP0870714789V1 1300 1916 1 b4 L1:815418.2:2000SEP086494084H 1 1307 1956 164 LI:815418.2;2000SEP085585079H1 1320 1561 164 LI;815418.2;2000SEP08g1887342 1316 1694 164 LI;815418.2:2000SEP0840759086 1323 1912 1 b4 LI:8154 T 8.2:2000SEP083539334H 1 1341 1526 164 LI:8 T 5418.2:2000SEP082434087H T T 463 171 T

1b4 LI:815418.2:2000SEP088033808H1 1 594 1 b4 LI:815418.2:2000SEP08585591778 1578 2176 164 LI;815418.2;2000SEP086543688F8 1519 2180 164 LI:815418.2;2000SEP0870713698V1 1026 1'173 1b4 LI;815418.2;2000SEP081646119H1 1438 1676 164 LI:815418.2:2000SEP084401248H 1 802 1028 1 b4 LI:815418.2:2000SEP087679539) 1 1561 1894 164 LI:815418.2;2000SEP087751992H1 1544 2240 164 LI:815418.2;2000SEP082445350H1 1548 1811 164 LI:815418.2:2000SEP08841793H1 1547 1761 164 LI:815418.2;2000SEP086588605H1 1536 1590 164 LI;815418.2:2000SEP081712775H1 1247 1442 l b4 LI:815418.2:2000SEP087368595H 1 473 1095 SEQ ID Template ID Component Start Stop NO: ID

i64 LI;815418.2;2000SEP087601736)1 798 1004 l b4 LI:815418.2;2000SEP085852466H 1 1410 1727 164 LI;815418.2:2000SEP081635358H1 1594 1808 1 b4 LI:815418.2;2000SEP086129968H 1 1601 1697 1 b4 LI:815418.2;2000SEP083967245H 1 1605 1770 164 LI:815418.2:2000SEP085274225H 1 1618 1886 164 LI:815418.2:2000SEP081623289H 1 1618 1808 164 LI:815418.2;2000SEP082302331 H1 1618 1766 164 LI:8 i 5418.2:2000SEP08787538H 1 1405 1710 164 LI:815418.2:2000SEP085667061 H1 1406 1635 164 LI:815418.2:2000SEP087054622H 1 1410 1658 764 LI:815418.2;2000SEP081479523H1 1352 1602 164 LI:815418.2:2000SEP088010391 H 1 598 164 LI:815418.2:2000SEP082561408H1 1493 ' 1799 1 b4 LI;815418.2:2000SEP087699484H 1 601 1173 164 LI;815418.2:2000SEP08412737078 1897 2187 1 b4 LI:815418.2:2000SEP085162201 F8 13 682 164 LI:815418.2;2000SEP087702057)2 556 1151 i 64 LI:815418.2;2000SEP087369319H 1 1588 2013 164 LI:815418.2:2000SEP0871617263V1 1647 2308 1 b4 Ll;815418.2:2000SEP081255582H 1 1412 1670 164 LI;815418.2:2000SEP08653870578 1896 2184 164 LI:815418.2:2000SEP087632804) 1 905 1530 1b4 LI;815418.2:2000SEP087438620H1 899 1511 164 LI:815418.2;2000SEP08g653173 1783 2062 164 LI:815418.2;2000SEP0871596964V1 1772 2273 164 LI:815418.2:2000SEP085105432H 1 1790 1895 1 b4 LI;815418.2:2000SEP087699484) 1 238 969 164 LI;815418.2:2000SEP087975382H2 312 1037 1b4 LI:815418.2;2000SEP085291313H1 1247 1489 1 b4 LI :815418.2:2000SEP087720601 J 583 1190 164 LI:815418.2:2000SEP085401644H 1 1246 1385 164 LI:815418.2:2000SEP083538879H 1 1247 1554 164 LI:815418.2;2000SEP087987963H1 627 1261 1 b4 LI;815418.2:2000SEP084230039N i 1863 2138 l b4 LI;815418.2:2000SEP083899890H 1 1067 1366 164 LI;815418.2;2000SEP083992872H1 1067 1381 164 LI;815418.2:2000SEP087952270H2 476 1122 164 LI;815418.2:2000SEP0871596167V1 1762 2253 164 LI:815418.2;2000SEP085i 62201 T8 1682 2198 164 LI:8154i 8.2:2000SEP088113755H 1 1 548 1 b4 Li:815418.2:2000SEP084438341 T8 1523 2235 164 LI:815418.2:2000SEP087383380H1 1516 2071 164 LI:815418.2;2000SEP087460571 H1 1531 2186 1 b4 LI:815418.2;2000SEP086124892H 1 1001 i 653 164 LI:815418.2:2000SEP088122761 H 196 599 ~

i b4 LI:815418.2;2000SEP085225160H 1 1409 1681 1 b4 LI:815418.2:2000SEP08" 1461381 1271 1471 _ _-__. H 1 -~00 SEQ ID Template ID Component Start Stop NO: ID

164 LI:815418.2:2000SEP086538705F8 1888 2182 164 LI;815418.2:2000SEP087228045H1 1412 1882 164 LI:815418.2:2000SEP082017950H 1 1633 1949 1 b4 LI:815418.2:2000SEP08800 i 279H 1 535 164 LI:815418.2:2000SEP084855067H1 1410 1683 164 LI:815418.2:2000SEP084773987H 1 1047 1329 164 LI:815418.2;2000SEP08612 T 184H 1001 1682 164 LI:815418.2:2000SEP083843355H1 1037 1139 164 LI:8154i8.2:2000SEP085018048H1 1042 1299 T 64 LI:B T 5418.2;2000SEP084525432H 1 12 105 1 b4 LI:8 T 5418.2:2000SEP081372242H 1 1489 1747 164 LI:815418.2;2000SEP082100808H1 1087 1351 164 Li.8154 T 8.2:2000SEP087426224H 1 i 082 i 669 164 LI:815418.2;2000SEP087646456)1 791 1296 164 LI:815418.2;2000SEP083175396H1 895 1146 T 64 LI:815418.2:2000SEP082354245H 1 2037 2143 164 LI:815418.2:2000SEP08654368818 2021 2219 164 LI :8154 T 8.2:2000SEP0871 625604V 2037 2319 164 LI:815418.2;2000SEP084732632H 1 ~ 1965 2059 1 b4 LI:815418.2;2000SEP086033960H 1 845 1376 1 b4 LI:815418.2:2000SEP088044133) 1 857 1173 164 LI;815418.2:2000SEP088057625)1 844 1523 164 LI;815418.2:2000SEP085070406H1 849 1132 164 LI:815418.2:2000SEP087076001 H 864 1101 1 b4 LI:815418.2;2000SEP087406388H 1 866 1485 164 LI;815418.2:2000SEP087738163)1 864 1479 164 LI;815418.2:2000SEP087644181)1 826 1176 1 b4 LI:815418.2;2000SEP087644181 H1 826 1173 164 LI;815418.2;2000SEP087736390) 1 20 703 1 b4 LI:815418.2:2000SEP087702057H 1 552 1151 164 LI:815418.2:2000SEP0.870715511 V 1439 1 b 164 LI;815418.2:2000SEP088102648H1 812 1485 164 LI:815418.2:2000SEP084399048H2 1270 1525 1b4 LI:815418,2:2000SEP081403839H1 1256 1499 1b4 LI:815418.2;2000SEP08697653H1 1259 1394 164 LI:815418.2:2000SEP08g944425 1268 1668 1 b4 LI:815418.2;2000SEP081259220H 1 1269 1587 1b4 LI;815418.2:2000SEP088001028H1 161 640 164 LI:815418.2:2000SEP087979296H1 1 598 T 64 LI:815418.2:2000SEP08601029H 1 1252 1527 1b4 LI:815418.2;2000SEP087247435H1 1886 2174 1b4 LI:815418.2;2000SEP084457273H1 1494 1801 164 LI:8 T 5418.2:2000SEP08200841 OH 1495 1593 164 LI:815418.2;2000SEP087456389H1 1863 2040 i b4 LI:815418.2:2000SEP087456775H 1 1867 2034 1 b4 LI:815418.2:2000SEP088015933) 1 1552 2034 1 b4 LI:815418.2:2000SEP08622713H 1 1555 1802 164 LI:815418.2:2000SEP088043833) 1 1580 2043 _ -201 SEQ ID Template ID Component Start Stop NO; ID

164 LI:815418.2:2000SEP086314259H1 1557 2047 164 LI;815418.2:2000SEP086115729H1 1562 1846 1 b4 LI:815418.2:2000SEP0824531 O1 H 1560 1704 164 LI:815418.2;2000SEP082238844H1 1565 1827 164 ~ LI:815418.2:2000SEP082238836H1 1565 1827 164 ~ LI:815418.2:2000SEP086040576H1 1570 2034 1 b4 LI:815418.2;2000SEP085101212H 1 1570 1746 1 b4 LI:815418.2:2000SEP086831007) 1 1573 1795 164 LI:815418.2;2000SEP08g651765 1578 1944 164 LI:815418.2:2000SEP088047502H1 1581 2171 164 LI;815418.2:2000SEP083020957H1 1358 1603 1 b4 LI:815418.2:2000SEP081927501 H 1390 1690 164 LI:815418.2;2000SEP082014262H1 1395 1672 164 LI:815418.2:2000SEP087661174)1 1397 1856 164 LI:815418.2:2000SEP083561117H1 1397 1737 1b4 LI:815418.2:2000SEP085991862H1 1397 1701 164 LI;815418.2:2000SEP083373054H1 1400 1693 164 LI:8 i 54 i 8.2:2000SEP083333394H 1 1403 i 7 i 3 1b4 LI;815418.2:2000SEP084106163H1 1405 1703 164 LI:815418.2:2000SEP081906326H1 1364 1556 164 LI;815418.2;2000SEP0871594488V1 1376 1783 164 LI:815418.2;2000SEP081444273H1 1374 1656 164 LI:815418.2;2000SEP083026558H1 1380 1719 1 b4 LI:815418.2:2000SEP08633226H 1 1386 1656 164 LI;815418.2;2000SEP083983144F6 1109 1487 1 b4 LI:815418.2:2000SEP085578114H 1 1426 1682 164 LI:815418.2:2000SEP0871592121 V 1581 2203 164 LI;815418.2:2000SEP087719344)1 6 657 164 LI:815418.2:2000SEP085759255H1 1 295 164 LI:815418.2:2000SEP0871597062V1 1510 2196 1 b4 LI:815418.2:2000SEP081792905H 1 1505 1804 164 LI:815418.2:2000SEP083761879H1 921 1148 1 b4 LI:815418.2:2000SEP082194839H 1 926 1173 1 b4 LI;815418.2:2000SEP08g2009100 ~ 932 1173 164 LI:815418.2:2000SEP081813648H1 951 1169 164 LI;815418.2:2000SEP082464660H1 951 1173 164 LI;815418.2:2000SEP08g1695375 976 1155 1 b4 LI:815418.2:2000SEP08664490H 1 969 1173 1 b4 LI:815418.2:2000SEP084438341 H 982 1173 1 b4 LI:8 i 5418.2;2000SEP084098865H 1 976 1176 164 LI:815418.2;2000SEP086610789)1 973 1614 164 LI:815418.2:2000SEP084849354H1 997 1173 1 b4 LI:815418.2;2000SEP086610789H 1 984 1 b 1 b4 LI:815418.2:2000SEP08g 1963049 1002 1179 164 LI:815418.2:2000SEP085275129H1 1412 1683 1b4 LI;815418.2:2000SEP086196729F8 1772 1895 1 b4 LI:815418.2:2000SEP087700830) 1 1 639 1 b4 LI:815418.2:200OSEP088048312H 1 1752 2185 SEQ ID Template ID Component Start Stop NO: ID

164 LI;815418.2;2000SEP087438277H1 743 1173 1 b4 LI:815418,2:2000SEP088037826) 1 763 1399 164 LI:815418.2;2000SEP087640014)2 767 1352 164 LI:815418.2:2000SEP088044155) 1 777 1173 1 b4 LI;8 i 54i 8.2;2000SEP084999883H 1 891 1 i 1b4 LI;815418,2;2000SEP084770709H1 1247 1509 1 b4 LI;815418.2:2000SEP083795463H 1 1247 1522 164 LI;815418.2;2000SEP087720648H1 158 774 164 LI:815418,2:2000SEP087605501 J 88 734 164 LI;815418.2;2000SEP08775830bHi 147 822 164 LI;815418,2;2000SEP087638818H1 158 637 164 LI;815418,2;2000SEP087959989H1 158 831 1 b4 L1:87 5418.2;2000SEP087646833) 1 158 783 164 LI;815418.2;2000SEP084161355H1 1220 1523 1 b4 LI:815418.2:2000SEP087736390H 1 1230 1966 164 LI;815418,2;2000SEP0855017124)1 499 654 164 LI:815418,2:2000SEP085855917F8 1568 2166 1 b4 LI:815418.2;2000SEP08384335578 1515 2220 164 LI;815418.2;2000SEP087618260H1 1517 2046 164 LI:815418,2;2000SEP085105938H1 1922 2215 164 LI:815418.2;2000SEP08g7037738 1930 2317 164 LI:815418,2;2000SEP08g7156198 1965 2317 164 LI;815418.2;2000SEP085855917H1 2016 2120 1 b4 LI:815418,2:2000SEP087984084H 1 480 976 164 LI:815418.2;2000SEP088033808)1 1588 2324 1 b4 LI:815418,2:2000SEP088008591 H 1 694 164 LI:815418,2;2000SEP086440272H1 1006 1317 1 b4 LI:815418.2:2000SEP087089726H 1 1902 2044 164 LI;815418,2;2000SEP087604808H1 1907 2167 1b4 LI;815418.2:2000SEP08- 7581949H1 1907 2133 164 LI:815418,2:2000SEP082570255H1 1015 1173 164 LI;815418,2;2000SEP083843355F8 1037 1774 164 LI:815418,2;2000SEP087966935H1 1906 2188 1b4 LI:815418.2;2000SEP084296937H1 907 1142 1b4 LI;815418,2:2000SEP086937329H1 626 1184 1 b4 LI:815418.2;2000SEP08g6577230 1916 2321 164 LI:815418.2:2000SEP08692642H 1 1417 1 b 164 LI;815418.2;2000SEP087620414)1 1423 2132 1 b4 LI:815418,2:2000SEP081267495H 1 1118 1359 164 LI:815418.2;2000SEP084672356H1 1213 1493 1b4 LI:815418,2:2000SEP08398314476 1139 1515 164 LI;815418,2:2000SEP0871654110Vi 1750 2273 1 b4 LI;815418.2;2000SEP088001501 H 1 406 164 LI;815418.2:2000SEP087977294H1 1 714 164 LI;815418,2;2000SEP082963978H1 1449 1700 164 LI:815418.2;2000SEP085838520H1 1450 1720 164 LI:815418.2;2000SEP081419517H1 1450 1714 164 LI:BI 5418.2:2000SEP087159_6483V 1735 2196 _ SEQ ID Template ID Component Start Stop NO: ID

164 LI:815418.2:2000SEP081622188H1 1462 1686 1 b4 LI:815418.2;2000SEP084549877H 1 1469 1610 164 LI:815418.2:2000SEP08805118H 1 1473 1671 164 LI:815418.2;2000SEP081905966H1 1475 1763 l b4 LI:815418,2:2000SEP0870 T 130H 1487 1779 1 b4 LI;815418,2:2000SEP084854967H 1 1410 1683 164 LI:815418,2:2000SEP082240255H2 1411 1663 164 LI:815418,2:2000SEP082189166H1 1411 1524 1b4 LI;815418.2;2000SEP0871596336V1 1678 2106 164 LI:8 i 5418,2:2000SEP086476992H i 1692 2302 164 LI;815418,2;2000SEP087437046H1 1755 2318 164 LI;815418,2:2000SEP0871595986V1 1722 2294 1 b4 LI :815418.2:2000SE7676864) 1 1724 1809 164 LI:815418.2:2000SEP087452964H1 647 1173 164 LI:815418,2;2000SEP087453093H1 647 1173 164 LI;815418,2:2000SEP087453048H1 647 1182 164 LI;815418.2:2000SEP087453010H1 647 1173 1b4 LI:815418.2;2000SEP087438496H1 655 1097 1 b4 LI:BI 5418.2:2000SEP087426104H l 675 1187 1 b4 LI:815418,2:2000SEP087455425N 1 727 ~ 1173 1 b4 LI:815418,2;2000SEP087601774) 1 729 1173 1 b4 LI:8154 T 8.2:2000SEP08g2070032 1272 1672 164 LI;815418,2:2000SEP084969651H1 1271 1532 164 LI:815418,2:2000SEP08g2189893 1271 1694 T64 LI;8T5418.2;2000SEP082170391HT 1271 1460 164 LI:815418.2:2000SEP087660291 H1 1282 1894 1 b4 LI:815418.2:2000SEP0871596226V 1989 2179 1 b4 LI;815418,2:2000SEP0871596061 V1 .1991 2179 1 b4 LI:815418,2;2000SEP083234752F6 1978 2356 164 LI:815418.2:2000SEP083234752H1 1957 2022 164 LI:815418,2;2000SEP0871592276V1 1674 2194 1b4 LI;815418.2:2000SEP087646456H1 1469 1846 1 b5 LI:4167bb.1:2000SEP084031856H 1 1252 1486 1b5 LI;4167bb.1:2000SEP086199132H1 1561 2074 165 LI:416766.1:2000SEP0870856083V1 1953 2465 165 LI;416766.1;2000SEP08g4190333 681 1064 1 b5 LI:416766.1:2000SEP08g4334177 2909 3276 165 LI:4 i 6766. i 708551 ObV 2939 35 i :2000SEP08 1 1 165 LI;416766.1:2000SEP08g2715986 2943 3267 1 b5 LI:41 b7bb,1:2000SEP086513330H 1 3000 3292 1 b5 LI:416766, T :2000SEP08g 1242884 680 1022 1 b5 LI:416766.1:2000SEP087211424H 1 2357 2667 1 b5 LI:416766.1:2000SEP085694841 T6 728 1171 165 LI:416766.1:2000SEP08g2240560 741 1234 1 b5 LI;416766,1:2000SEP08g6438877 672 1094 165 LI:416766,1:2000SEP08g2070577 2906 3275 1 b5 LI:41 b766.1;2000SEP08g3665440 675 1140 l 65 LI:4l 6766.1:2000SEP08g5231632 675 17 Ob ~U4 SEQ ID Template ID Component Start Stop NO: ID

165 LI;416766.1;2000SEP08g6040151 678 1130 1 b5 LI;416766.1:2000SEP08243195H 1 3007 3127 165 LI;41676b.1;2000SEP08296137376 3005 3227 165 LI:41 b7bb.1:2000SEP087011821 F8 673 T 20 i 165 LI:41 b7bb.1;2000SEP08g3679253 675 1146 165 LI;416766.1;2000SEP083515501 H 2101 2344 165 LI:41 b7b6.1:2000SEP0871225989V 2357 2930 165 LI:416766.1:2000SEP085695241 T8 884 1339 165 LI:41 b7bb.1;2000SEP08g 1367787 1001 1619 165 LI:41 b7bb,1;2000SEP08g5554573 675 1154 165 LI:41 b7bb.1;2000SEP087011821 H1 675 1121 165 LI;41676b. T :2000SEP0870854872V 2807 3398 T

i 65 LI;41 b7bb.1:2000SEP08g4629623 28 i 9 3267 165 LI:4167b6.1:2000SEP08g5512397 2827 3268 165 LI:41 b7bb.1:2000SEP08g5661867 2843 3298 1b5 LI;4167bb.1:2000SEP08g1367813 806 1584 1 b5 LI:416766.1:2000SEP08g5511864 2858 3268 165 LI;41 b7bb.1;2000SEP085445604H 1 2856 3097 165 LI;4167b6.1:2000SEP081251913H1 3132 3273 165 LI:41 b7bb.1;2000SEP081251913F6 3138 3216 165 LI:416766.1:2000SEP082853591 Tb 3149 3559 1 b5 LI:416766.1:2000SEP08g897183 3359 3638 165 LI;416766.1:2000SEP08g2057056 2513 2870 165 LI;4167b6.1;2000SEP082551309H1 2437 2682 165 LI:4167bb.1:2000SEP0870856882V1 2695 3332 165 LI:416766.1:2000SEP084787383H1 2794 3046 165 LI:416766.1:2000SEP082961373F6 3012 3262 165 LI;4167b6.1:2000SEP082961373H1 3014 3142 165 LI:416766.1:2000SEP085308958H1 3051 3271 1 b5 LI:4167bb.1;2000SEP087169394H 1 1 343 1 b5 LI:416766.1:2000SEP08377885979 212 607 1 b5 LI:4167b6.1;2000SEP08377885978 218 573 1 b5 LI:41 b7bb.1:2000SEP083778859F8 221 733 1 b5 LI:4l 67bb.1:2000SEP083778859F9 223 736 165 LI;41b7b6.1:2000SEP083778859H1 218 554 1 b5 LI:4167bb.1;2000SEP087664249H 1 493 1063 l b5 LI;416766.1;2000SEP086011335681 613 1062 1 bb LI;1171008.2:2000SEP088068537) 1 12 456 1 bb LI;1171008.2:2000SEP08g 1984991 1 260 166 LI:1171008.2:2000SEP08g4187090 1 210 1 b7 LI;1169888.3:2000SEP08g4082551 1 249 1 b7 LI:1169888.3:2000SEP08g6655195 5 260 167 LI:1169888.3;2000SEP083069995F6 54 502 1 b7 LI:11 b9888.3:2000SEP083069995H 1 54 348 1 b7 LI:1169888.3:2000SEP087598547H 1 154 710 1 b7 LI:11 b9888.3:2000SEP085678086H1 170 353 167 LI:1169888.3:2000SEP084731429H1 209 476 167 LI:1169888.3:2000SEP084387033H 1 264 519 _._ - _ -_.

20~

SEQ ID Template ID Component Start Stop NO; ID

1 b7 LI:1169888.3:2000SEP088107619H 1 382 636 1 b7 LI:11 b9888.3;2000SEP082170650H 1 409 655 1 b7 LI:1169888.3:2000SEP085069257H 1 544 834 1 b7 LI: T T b9888.3:2000SEP086883261 F8 550 903 1 b7 LI:1 i b9888.3;2000SEP086883261 H 550 969 1 b7 LI:1169888.3;2000SEP086052251 J 660 1024 167 LI:1169888.3:2000SEP087939216H 1 836 1314 1 b7 LI:1169888.3:2000SEP088107287H 1 853 992 1 b7 LI:11 b9888.3:2000SEP088107287) 1 853 992 167 ' LI:1169888.3:2000SEP08g6656112 1 266 167 LI:11 b9888.3:2000SEP08g4086074 1 249 168 LI;4T 2592.1:2000SEP083722057H 1 805 1116 168 LI:4 T 2592. T 7695603) 1 587 1099 :2000SEP08 1 b8 Ll:4T 2592, i 6704220H 1 698 931 :2000SEP08 1 b8 L1:412592.1:2000SEP085321546F9 768 1275 168 LI;412592.1:2000SEP085302969F8 769 1327 1 b8 LI:412592.1:2000SEP087707755H 1 221 845 1b8 , LI;412592.1:2000SEP087623656H1 216 843 1 b8 LI;412592.1;2000SEP087611095) 1 227 909 ~

1 b8 LI:412592.1;2000SEP08069300H 1 191 307 i 68 LI:412592.1:2000SEP088035862) 1 197 721 1 b8 LI;412592.1:2000SEP087728679) 1 217 842 T 68 LI:412592.1:2000SEP087441308H 1 211 811 T b8 LI:412592. T :2000SEP086907021 H 1 360 1 b8 LI:412592.1:2000SEP082573121 H 1 1 6l 1 b8 LI:412592.1;2000SEP08797431 6H 313 912 1 b8 LI;412592.1:2000SEP087623823H 1 318 809 1 b8 LI:4 T 2592.1;2000SEP087754904H 1 442 763 1 b8 LI;412592.1:2000SEP087696804) 1 543 1107 168 LI:412592.1:2000SEP087707 T 80J 257 927 1 b8 LI:412592.1:2000SEP088084683H 1 271 938 168 LI;412592.1:2000SEP088083727H1 271 958 1 b8 LI:412592.1:2000SEP088085224H 1 271 806 1 b8 LI:412592.1:2000SEP086599039H 1 286 399 1 b8 LI:412592.1:2000SEP087723213H2 309 890 168 LI;412592.1:2000SEP087620469H1 229 816 T 68 LI:412592. T :2000SEP08493 T 878T8 896 1 T

1 b8 L1:412592. i :2000SEP087439217H 1 9 T 9 1501 1 b8 LI:412592.1:2000SEP087743523) 1 1031 1174 169 LI:349808.1:2000SEP086819387H1 1704 2094 169 LI:349808.1:2000SEP086819295H1 1705 2094 169 LI;349808.1:2000SEP083597372H1 1 287 169 LI:349808.1:2000SEP081b27bbOH1 1090 1292 169 LI:349808.1:2000SEP087948057H1 1185 1758 169 LI:349808. T :2000SEP087110908F8 2576 2855 169 L1:349808.1:2000SEP087429309H1 2046 26T

1 b9 LI:349808.1:2000SEP08675535788 2403 2855 1 b9 LI:349808.1;2000SEP083_579765H 22 323 _.__ 1 _ .206 ' --_ SEQ ID Template ID Component Start Stop NO: ID

1 69 Li:349808. T :2000SEP087281181 H 34 136 169 LI:349808.1;2000SEP086604801 H1 1061 1229 1 b9 LI:349808. 1 :2000SEP088035241 J 950 1 632 169 LI;349808, 1 :2000SEP082495529H 1 557 628 169 LI:349808.1:2000SEP087689446) 1 582 1147 169 LI:349808.1;2000SEP087584138H1 601 1169 l b9 LI:349808.1;2000SEP082306387H 1 613 878 169 LI:349808.1;2000SEP088018981 J 793 1402 1 b9 LI;349808, 1 ;2000SEP088035241 H 1415 1994 169 LI:349808.1;2000SEP086914347H 1 1242 1643 169 LI;349808.1;2000SEP081415229H1 1544 1811 169 LI:349808.1;2000SEP08803461 OJ 1896 2588 T

169 LI:349808.1:2000SEP086819387) 1 1705 2094 169 LI:349808.1;2000SEP086819295) 1 1705 2092 169 LI:349808.1:2000SEP08681938788 1705 2086 1 b9 LI:349808.1:2000SEP082653094H 1 1722 1947 169 LI;349808.1:2000SEP086819387F8 1791 2094 169 LI;349808.1:2000SEP086910219)1 1874 2060 169 LI:349808.1;2000SEP083381265H 1 2434 2701 169 LI;349808.1;2000SEP086755357)1 2433 2854 169 LI;349808.1:2000SEP087110908H1 2575 2854 169 LI;349808.1;2000SEP083319124F6 40 566 169 LI;349808.1;2000SEP083319124H1 40 314 169 LI;349808.1;2000SEP08g4080691 56 303 169 LI;349808.1:2000SEP087994037H1 68 646 169 LI;349808.1:2000SEP087253443H1 69 521 169 LI:349808.1;2000SEP08546961 H 1 9 288 1 b9 LI:349808.1;2000SEP081430402F6 477 779 1 b9 LI:349808.1;2000SEP081430402H 1 477 723 169 LI:349808.1;2000SEP087689446H 1 334 595 1 b9 LI:349808.1:2000SEP088034434) 1 348 1007 169 LI:349808.1:2000SEP087405584H1 306 794 169 LI:349808.1;2000SEP088117848H1 77 692 170 LI:3491b4.2:2000SEP087622234H1 1 446 170 LI;349164.2;2000SEP087622884H1 1b2 769 170 LI;349164.2:2000SEP086911488H1 588 1066 170 LI:3491 b4.2:2000SEP086274443H2 352 945 170 LI;349164.2:2000SEP083027742H1 431 716 170 LI;349164.2:2000SEP084301890H1 623 857 170 LI;3491b4.2:2000SEP086906443H1 645 1147 170 LI:3491b4.2;2000SEP0870857325V1 838 1059 170 LI;349164:2:2000SEP084457564H1 938 1178 170 LI:349i64.2:2000SEP084454771H1 944 1197 171 LI:205413.1;2000SEP08g2115617 1734 2232 171 LI:205413.1:2000SEP087950063H1 1730 2205 171 LI:205413.1:2000SEP08g 1548634 1462 1664 171 LI:205413.1:2000SEP08g 1476869 1462 1603 171 LI:20541 3.1:2000SEP082659489H 1 1508 1592 _-207 SEQ ID Template ID Component Start Stop NO; ID

171 LI:205413.1;2000SEP082659489F6 1508 2121 171 LI:205413.1:2000SEP087707719) 1 1544 2120 171 LI:205413.1:2000SEP08g2115614 1729 2232 171 LI:2054 i 3. i 5314004H 1 103 345 :2000SEP08 171 LI;205413.1;2000SEP08g3109828 1738 2124 171 LI:205413.1;2000SEP082505546N 1 i 794 1917 171 LI:205413.1;2000SEP083247411 F6 833 1105 171 LI:205413.1:2000SEP083247411H1 833 931 171 LI;205413. i :2000SEP086541837H 1 462 957 171 LI;205413.1:2000SEP087203862H1 467 751 171 LI:205413.1:2000SEP084541365H1 1165 ~ 1407 171 LI:205413.1:2000SEP083253915Th 974 1429 171 LI:205413.1:2000SEP084291253F6 143 474 171 LI:205413.1:2000SEP084291253H1 145 396 171 LI:205413.1:2000SEP087411467H1 247 792 171 LI;205413.1:2000SEP08195208386 2042 2214 171 LI;205413.1;2000SEP086629950U1 2042 2214 171 LI:205413.1;2000SEP087386810H1 273 874 171 LI:205413.1:2000SEP083024202H1 313 598 171 LI:205413.1:2000SEP087411330H1 576 1117 ~

171 LI:205413.1:2000SEP07950063) 1 1839 2418 171 LI;205413.1;2000SEP087065386H1 1899 2344 171 LI;205413.1:2000SEP085172246H1 1923 2150 171 LI:205413.1:2000SEP086873144H1 1956 2344 171 LI;205413.1;2000SEP082070268H1 553 702 171 LI:205413.1:2000SEP08g 1126720 493 725 171 LI:205413.1:2000SEP08g318198 560 859 171 LI:205413.1:2000SEP08178046H1 1028 1109 171 LI:205413.1:2000SEP087658127H1 992 1522 171 LI;205413.1:2000SEP08g3593212 1028 1336 171 LI:205413.1:2000SEP087707719H1 869 1514 171 LI:205413.1:2000SEP08325391586 956 1417 171 LI:205413.1:2000SEP087274523H1 1220 1625 171 LI:205413.1:2000SEP085996466H1 598 1217 171 LI;205413.1:2000SEP086101305H1 1215 1442 171 LI;205413.1:2000SEP082415b58Hi 2425 2616 171 LI:205413.1:2000SEP084757957H1 2464 2640 171 LI:205413.1:2000SEP084757957F6 2537 2848 171 LI:205413.1:2000SEP08g786768 2564 2857 171 LI;205413.1:2000SEP084757957Th 2704 2864 171 LI:205413.1;2000SEP081952083T6 2706 2762 171 LI:205413.1:2000SEP087073566H1 2718 2848 171 LI;205413.1:2000SEP081733231 Fb 2754 2848 171 LI;205413.1:2000SEP081733231H1 2754 2848 171 LI:205413.1:2000SEP08g812880 1 279 171 LI:205413.1:2000SEP081952083H1 2042 2214 171 LI:205413.1:2000SEP08g824629 2 285 171 LI:205413.1:2000SEP085311859H 1 103 365 _._ SEQ ID Template ID Component Start Stop NO: ID

17i LI:205413.1:2000SEP08g769342 2 234 171 LI:205413.1;2000SEP083253915N 1 956 1228 171 LI:205413.1;2000SEP087360936H 1 1074 1593 171 LI:205413.1:2000SEP087314994H i 1161 1592 171 LI:205413,1:2000SEP08g6299856 1223 1653 171 LI:205413.1;2000SEP08g4457741 1283 1466 171 LI;205413,1:2000SEP08g824868 1385 1759 171 LI:205413.1;2000SEP08g764871 1395 1759 17 i LI;205413. i :2000SEP081412476H 1 1430 1592 171 LI;205413.1:2000SEP08289182876 1174 1430 171 LI;205413.1:2000SEP083331088H1 691 947 171 LI:205413. i ;2000SEP083524383H1 2102 2411 171 LI;205413.1:2000SEP08g1275525 2170 2492 171 LI:205413.1;2000SEP086629920U1 2246 2642 171 LI;205413.1:2000SEP088068036J1 2271 2616 i 71 LI:205413.1;2000SEP087950631 J 2079 2394 171 LI:205413,1:2000SEP087950631 H 2100 2394 171 LI;205413,1:2000SEP086982879H1 1 315 i72 LI:205i508.2:2000SEP085770980H1 1073 1594 172 LI:2051508.2:2000SEP085770980F8 1085 1641 172 LI:2051508,2:2000SEP0877b548bHi 1353 1941 172 LI:2051508,2;2000SEP08gi303480 1368 1608 172 LI:2051508.2;2000SEP086355546H1 1473 1677 172 LI;2051508,2;2000SEP086568067H1 0 1 62 172 LI;2051508.2:2000SEP086267543F8 1 657 i 72 LI:2051508,2;2000SEP086568067F8 1 665 172 LI:2051508,2:2000SEP086267543H1 1 536 i 72 LI:2051508.2:2000SEP08626754378 158 699 172 LI:2051508,2;2000SEP087765486J1 501 1 i50 172 LI:205i 508.2:2000SEP085625452H 1 511 641 172 LI:2051508.2;2000SEP087388455H1 649 1075 7 72 LI:205 i 508.2;2000SEP087330071 H 870 i 307 173 LI:346242.2:2000SEP083679845Hi 1018 1218 173 LI:346242.2:2000SEP08408199378 983 1487 173 LI:346242.2;2000SEP087620566Hi 1003 1637 173 LI:34b242,2;2000SEP087649709H1 1003 1572 173 LI:346242.2:2000SEP087327034H 1 955 1471 173 LI:346242.2:2000SEP088056268) 1 730 1284 173 LI:346242.2:2000SEP0877 i 8357H 841 1325 i 173 LI;346242.2;2000SEP087468459H1 946 1471 173 LI;346242,2:2000SEP087662015)1 1026 1642 i 73 LI:346242.2:2000SEP086906628H 1 1031 14 i 173 LI;346242,2:2000SEP08g1685690 1060 1433 173 LI:34b242.2:2000SEP084180807H1 1118 1412 173 LI;346242.2:2000SEP084180807F6 1 T T i 487 173 t1:34b242.2;2000SEP082720980H1 1265 1373 173 LI;34b242.2;2000SEP087978939H1 1 479 i 73 LI:346242,2:2000SEP087741 i 09H 17 487 i SEQ ID Template ID Component Start Stop NO; ID

173 LI:346242.2:2000SEP088017662) 1 24 630 173 LI:346242.2:2000SEP086780866H 1 178 473 173 LI:346242.2;2000SEP087724708) 1 336 473 173 LI:34b242.2:2000SEP086764336) 1 339 472 173 LI:34b242.2:2000SEP08800b8b4Hi 451 1094 i 73 LI:34b242.2:2000SEP086915577H 1 615 697 173 LI;346242.2;2000SEP086797389H1 691 1241 173 LI:346242.2:2000SEP084052477H 1 702 784 i 73 LI:34b242.2;2000SEP083679845F6 1018 1097 173 LI:34b242.2;2000SEP082720988F6 1265 1373 773 LI;346242.2;2000SEP0871220924Vi 1275 1503 173 LI;346242.2;2000SEP08272098876 1301 1372 174 LI;2052717.1;2000SEP085067091 T9 828 1475 174 LI:2052717.1:2000SEP084894635F6 1126 1550 174 LI;20527i7.1:2000SEP084894635H1 1126 1402 174 LI:2052717. i 258300276 1173 1451 :2000SEP08 174 LI:2052717.1:2000SEP0885540945 1206 1551 174 LI:2052717.1:2000SEP085696575H1 1275 1532 174 LI:2052717.1:2000SEP088273554 624 810 174 LI:2052717.1:2000SEP086595153) 1 1490 1788 174 LI:2052717.1:2000SEP083002561 T7 1603 1729 174 LI:2052717.1:2000SEP083002561 H 1603 1763 174 LI;2052717.1;2000SEP086148958H 1 222 789 174 LI:2052717, i 7714444H 1 233 841 :2000SEP08 i 74 LI:2052717.1;2000SEP085067091 H 520 763 i 74 LI:2052717.1;2000SEP085067091 F9 523 1007 174 LI:2052717.1:2000SEP085063731 F8 543 1081 174 LI;2052717.1:2000SEP083002561 Fb 1603 1763 174 LI:2052717.1;2000SEP08g T 147397 i b 16 17 i i 74 LI:2052717.1;2000SEP0883593657 1697 1808 ' 174 LI;2052717.1;2000SEP0887041600 1703 1808 i 74 LI:2052717.1:2000SEP082583002F6 552 1057 174 LI;2052717.1:2000SEP082583002H1 552 819 174 LI:2052717.1;2000SEP086619463H1 1 57i 175 LI:406b68.2;2000SEP085672240H1 1258 1537 175 LI:40b668.2:2000SEP087002774H 1 i 601 2268 175 LI;406668.2;2000SEP087626312) 1 1261 1948 175 LI:406668.2:2000SEP08g 1718534 1278 1350 175 LI:40b668.2:2000SEP08i 390315H i 186 1449 i 175 LI:4066b8.2:2000SEP083744324F6 1018 1356 175 LI:40b668.2:2000SEP0881779107 1337 1662 175 LI;406668.2:2000SEP085336594H1 1334 1569 175 LI;406668.2:2000SEP084933068H 1 1336 1623 175 LI:406668.2:2000SEP0886703684 1600 2038 175 LI:406668.2:2000SEP087024005H 1 1359 1809 T 75 LI;406668.2:2000SEP081390315F6 1185 1604 175 LI;406668.2:2000SEP0885397998 2262 2362 175 LI:40b668.2;2000SEP08410500H1 2284 2393 _ SEQ ID Template ID Component Starf Stop NO: ID

175 LI:40b668.2;2000SEP085434671H1 2167 2384 175 LI:40b668.2:2000SEP088042801 H 1347 1638 175 LI:406668.2:2000SEP083336387H1 69 296 175 LI:40bb68.2:2000SEP086788039H1 195 340 175 LI:406668.2;2000SEP083336387F6 69 413 175 LI;40b668.2;2000SEP087674468)1 306 806 175 LI:40b668.2:2000SEP088042709) 1 736 1233 175 LI :40b668.2:2000SEP088042801 J 749 1313 175 LI:406668.2:2000SEP084126078H1 906 1084 175 LI:40b668.2:2000SEP084212553H1 1295 1516 175 LI:40b668.2:2000SEP08g 1718535 2092 2395 175 LI:406668.2;2000SEP083723230H1 2092 2392 175 LI:40b668.2:2000SEP08g 1780142 2101 2392 175 LI:40bb68.2:2000SEP082441933H1 2118 2310 175 LI:40bb68.2:2000SEP083744324H 1 1018 1251 175 LI:406668.2;2000SEP086454883H1 11 481 175 LI:406b68.2:2000SEP086569407H 1 34 466 175 LI;406668.2;2000SEP087723868) 1 1 461 175 LI;406668.2;2000SEP087985745H2 1 606 175 LI;406668.2:2000SEP083473241H1 8 259 175 LI:4066b8.2:2000SEP0882347904 1895 2391 175 LI:406668.2:2000SEP08- 82269419 1907 2391 175 LI:406668.2;2000SEP08~ 83149881 1297 1602 175 LI:406668.2;2000SEP0885660211 1936 2356 175 LI:406b68.2;2000SEP0885053468 1908 2391 175 LI;406668.2:2000SEP0884988156 1912 ' 2385 175 LI;406668.2:2000SEP0885440700 1928 2392 T 75 LI:40b668.2:2000SEP08493306876 2001 2340 175 LI:40b668.2;2000SEP085022603F9 1636 2065 175 LI;406b68.2;2000SEP086576919H1 1705 2168 175 LI:40b668.2;2000SEP08374432476 1725 2318 175 LI:406668.2:2000SEP087626312H1 1734 2340 175 LI:406668.2:2000SEP08461495876 1766 1952 175 LI;406668.2:2000SEP086870730H1 1832 2347 175 LI;4066b8.2:2000SEP08502260378 1845 2219 175 LI:40bb68.2:2000SEP087369624H 1 1894 2387 175 LI:4066b8.2;2000SEP085022603H1 1603 1732 175 LI:40b668.2;2000SEP084614958H1 1003 1244 175 LI:4066b8.2;2000SEP08- 4614958F6 1003 1573 175 LI:406668.2:2000SEP08875654H1 921 1167 175 LI:406668.2:2000SEP088042709H1 977 1649 176 LI:1178352.1;2000SEP0870867102V1 1509 1808 176 LI:1178352.1:2000SEP0871229547V1 241 896 176 LI:1178352.1;2000SEP0870868356V1 1129 1765 176 LI:1178352.1;2000SEP0871229578V 236 908 176 LI:1178352.1;2000SEP0870867476V1 1267 1808 176 LI:1178352.1;2000SEP0871300356V 21 O1 2550 176 LI:I 178352.1:2000SEP08_ 71228758V1 1070 1548 SEQ ID Template ID Component Start Stop NO; ID

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<110> INCYTE GENOMICS, INC.
JACKSON, Stuart LINCOLN, Stephen E.
ALTUS, Christina M.
DUFOUR, Gerard E.
CHALUP, Michael S.
HILLMAN, Jennifer L.
JONES, Anissa Lee YU, Jimmy Y.
WRIGHT, Rachel J.
GIETZEN, Darryl LIU, Tommy F.
YAP, Pierre E.
DAHL, Christopher R.
MOMIYAMA, Monika G.
BRADLEY, Diana L.
ROHATGI, Sameer D.
HARRIS, Bernard ROSEBERRY, Ann M.
GERSTIN, Jr., Edward H.
PERALTA, Careyna H.
DAVID, Marie H.
PANZER, Scott R.
FLORES, Vincent DAFFO, Abel MARWAHA, Rakesh CHEN, Alice J.
CHANG, Simon C.
AU, Alan P.
INMAN, Rebekah R.
<120> SECRETORY MOLECULES
<13.0> PT-1184 PCT
<140> To Be Assigned <141> Herewith <150> 60/229,751; 60/230,016; 60/229,749; 60/229,750; 60/229,747;
60/229,748; 60/230,583; 60/230,517; 60/230,599; 60/230,514;
60/230,988; 60/230,518; 60/230,515; 60/230,610; 60/230,597;
60/230,505; 60/230,519; 60/230,595; 60/230,990; 60/230,865;
60/230,989; 60/230,596; 60/230,864; 60/231,163; 60/230,896;
60/230,897; 60/231,832; 60/230,951 <151> 2000-09-05; 2000-09-05; 2000-09-05; 2000-09-05; 2000-09-05;
2000-09-05; 2000-09-05; 2000-09-06; 2000-09-06; 2000-09-06;
2000-09-06; 2000-09-06; 2000-09-06; 2000-09-06; 2000-09-06;
2000-09-06; 2000-09-06; 2000-09-06; 2000-09-06; 2000-09-06;
2000-09-06; 2000-09-06; 2000-09-06; 2000-09-07; 2000-09-07;
2000-09-07; 2000-09-07; 2000-09-07 <160> 369 <170> PERL Program <210> 1 <211> 964 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:983076.3:2000SEP08 <400> 1 aatggaactt aatgtctatt cctcttttct cttttctgtg ttaccaaagg gatctagagc 60 cttatgggta ctacttagaa aatgagcact catacatata caatatctgg aaataccttg 120 aaagtaatca cgaatactcc ttctgtttca cttccatact gctgaattgc ctcttcatct 180 tctgtcacca taacaattgg catcctgtcc tggcagtgat gatagtacca aacagctgcg 240 ttgtatatgc tcctggtctg ccacttctcc atggactctc ctctttcccg tggcagatag 300 cagcattgct ggaattcatt agcaaagaga atgcaatcat gacgcgcatc cttcagcagg 360 tttcgcagtt tgttatactg tctgtgacac ggaggagaaa aataactcta acaaagcagg 420 tactcatcca ctgctatctc ttgctaagga tcaaaaaagg atggggtatt ttagagccaa 480 agattgatta ctttaaacct gaagaacatg tatttatatt ggtctcagtg tgctcagtcc 540 tatcgggctg ctattgtttc tcgattttgc ctgctagaag gtgcttgggc agggcctagt 600 taattagttt gcagatcaat taaactcctt ccctctcctt tccccttcag agacttccag 660 ccattttatt atgtaattat accaccttgc cctgcctagc cccttcttca aagcctgagt 720 gcacggaggc aagcagagag tttagcactt tatttttgga cctcactttg ttctataaat 78D
gtcattaagc attaatacat ttgacttttt gctggcagcc ctagacaaga acatgtaagg 840 taaataagtt tggggattta tctgtgaatt ttatttatgc agccaccctg atttacataa 900 atgagagcta gcctcatctg tcagacaact aacagaaagt tttaaggttt tgtccatcaa 96D
gaga 964 <210> 2 <211> 790 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1382987.7:2000SEP08 <400> 2 , ggctgagcgg tgcccctccc accggcccac cagaggcccc ggctgttagc tgcatgtata 60 cttgtgttcc aggcttgcga actaaaattt cattggttaa ggatgtgaga agcgtcagcg 120 agatgtgtcc ttaacatctc tgaattcagc taaggtatgt gccttgtgaa gaaatctccc 180 acttggaaca cagccccaga agctctccat tcccagagtg gagttggaag caccacaagg 240 cttgctcagg gcaggcggag gagggccata ccatctcaca tccagccagc tcatggttcc 300 aacgggcttc catcaggctg tggagaacct gagggtagat ggtcaggatt ctggaaaagt 360 tctgcagacg gcttctgaaa cgctggtagg caaggtgcac ccacggtaag gaaacctctt 420 cctcgggcgc ttctgacgcc gctttcagtt tcctagtgca ggaccacaga gccatctgca 480 gaaactggga ttcaaacaag cttttagaat atatttttaa attacaaaaa tggtatgttt 540 tccccgtggg aaatccgaac tattggaaaa ccatacaaag aggaaattag aaaccatgtg 600 tgctattctg tcccgtttgc ttctgtccag ttttctatct gcctctcctc ccacgttaag 660 gtcaccgtgt cgtctgggct ttttgccact gaacatgaca tcatgaactt tccctatgac 720 tgagtatact tgaaacacag tggttttaat ggctgctcaa taacccatca tacggccata 780 ctttaatttc 790 <210> 3 <211> 291 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:235557.15:2000SEP08 <400> 3 cctcttttta aaatttctgc taacttgata ggtgaaaaac agtagtttat ttaatctgca 60 tttctctgta tttcagatgc atgctgcctt ttttgtaaat tctagtcttc tttttgttca 120 tttacctttt gggatcttag tttccttatg aatatttgag ctttttagta tgtaaataat 180 aatcatgtgt cattctgtta cagacatact ttccattgtt gctcttaatt ttgtattaac 240 actcagatgc cctgagtctt tcagaggttt ttattttttg agaccgagtc t 291 <210> 4 <211> 805 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:018494.1:2000SEP08 <400> 4 atagatgctg aaaggctaat acacacatat gcacatgtat ttgattgtca aaggtatatt 60 cttaaatttg ggtattattg aaaatatttt ccatgccttg gtgctagcat ataagtttgg 120 aagtttgcca acatcacaat tcatcttgaa aagagctttt ttccctccta ccacatacac 180 cattcttagg gagcaatgag gtaacaggtc tgtgttgtct agatctttgc tttttatccc 240 cctatcagtc cagggcatat actaacctgc aaactgattc tgaatcagga aggtggtaat 300 caataagtat tctggctggg aaagaccgtg ggcccaatga tcaaagtctt cttggtgctg 360 ttcattaatt cttgtgcctt ttggcttgtt ttctagagtt tctgggcttt ggctgctgat 420 actgcctttc ttagactgta atttttatct gcatgcccag tttctgacct atcaacttgg 480 gttttattgt gcactctaac tgagcttgtc ttcataattt tctgtttatt gccctgggct 540 tggatatgtc tcaagacact catgtgaatc atgccacccc aaatcctggc ttatcaagtc 600 ccagactata aattatgaac tcccattagc ttggtactaa catatacttg atgtaggtat 660 ttatggactt gatgatccaa gaatattata ttcttcaaaa tggttaagct ccatggagtt 720 agatgactac acttaatgct attaagttga acttttgaat gtcaactaat ttgcaatcaa 780 ttaaagatac atatgcctag aaaaa 805 <210> 5 <211> 1877 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:980494.1:2000SEP08 <400> 5 cgttcagtgg ttcccggcac gctcagggtg cagtgtaggg tctgaatgtg tgtattgcgg 60 gggtaggggg agtggtgtca gttctaggcc acaggaattc gtggtctggc cccagaggtg 120 cggtgttttt ggccgggaag tcaggcagaa gtctgcagcg tgcaactcgc agcggggcgt 180 gtgtgtgcgt gtgtgcgcgc gcgtgtgcat gtttccggcc cggggtcgcg tgtgtggctg 240 cagcctgtct ccgtgacaag aagatccagg gatctacggg cggcacgggg aagggattaa 300 ggggaacata cttccctacg tcttttctgc ctccttttcc cagggtagca ttctttgctt 360 atccaatgat gcctctttct aacctctccc tctccactta catcccaaac ctgatgcggg 420 tcttctctga ttcggcactc taaggaggac tcagccgccg gctgcgacca ccgtggactc 480 cctctatgga agggaatcct gggagtcccg gccgtcagag gggttcccaa atccaaaggg 540 tccatctcca aggcgtcact ccaggggtcc gcggttcact ttgctgcccc ttgcaggtga 600 tgctgtgatt gttgcctgcg gactgggaag cacgatggct ccaaaaggcc agcggggccg 660 agaagcaggg acagagacca gcatttaagg gatctctggt gggggcctcc ctggagttct 720 ccacatgtaa atatagcgaa aaaagaaaac actacgttac tagaataaac acgtcctaaa 780 atttctgtgc aaaaacacct ttttgaacag caaagatttc acccaccaaa acaaggaagc 840 aagaagcttc cacagtgtgc aggatccgaa acaggaccgg cccggcgttg ggtgagagtg 900 ggggaggggt tgtcggcttc tccatccagc ttgccatgtt ctgtcgtcgg tttcacattt 960 tcagagagac tttaccagat gcaggaaatg aggatgaagg caactctgga aggatgcaaa 1020 gaagggagag caagcactgt acctactgtc tgctgtctaa gagggctggt ctcataacta 1080 aaaggtccag tccctgagat cttgtgtgca accgtcagaa atagttcagg acatcaaatt 1140 gcacagagaa gattcagatg aagggaaaca agaactctgt ggaaaactgt tggggacagt 1200 ggcacgagtt gtcttgcaag gtgatgtctg tcccgtggag ggacacaaga gcgaggacag 1260 catggttcta atggccaggg catgtcttct tattccatgt gacagtggct ggctgagttg 1320 ctagtacgtt tttgaaatat accctttgaa atatgttgat tattctggac atctgtaagg 1380 tgggagattt gaataaaaag acttctgctg tcattattgg cttttatggc tatgattttt 1440 ttcagtcatt attataaatc atgtgaaggt aaaataaatg atcattttag ccattctgtt 1500 ctgcacagaa tgctgttcaa ataaaacatc atctgatatg tttgcctgta ttgttttgtt 1560 tgggggtcac ggaagaggga aagtcggcca aattgattag ggtatcatat aaaagcagag 1620 attaggtccg ggtagatctt ttgagtgtgt gcaggaaaag gcttcattat agaatgctaa 1680 atttaatgtg agatgagaga atcttttact cccgatctcc tgcatttgaa atacaaagga 1740 ttgtaccctt gggctggttc ctggtcctta agtggaagcc taactggaca ctttttttct 1800 ggaggattgt tccctaaatc ctgggaagct ttagaaaata gtcaatggaa tttttgttgc 1860 cctaagataa agtcatt 1877 <210> 6 <211> 1273 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:984457.2:2000SEP08 <400> 6 tcactacagg tcaaaaccaa gagagaatgt gtagttttca aggtcttggc cagaaccttt 60 aggaaagaag acctgtttat acattgaagg aagaaaagaa ggaagcagtt gccttccgga 120 gggggctctg agagaatcta gcctcccctc tgtcctattg gagcaaagat tggagtgagt 180 gttgccacca acaggatttt atcgtttgac tccaatacct gaaattctga cttctctcct 240 gtgcttcaat gagaatgata aattatccta gcaaaggggc ctctggagac catcttgttc 300 cagcctctga agacagttga ggagatcaag cccagcaatg gtggcagaat cttactccac 360 agacttcagc agactagtca tttcaatacc caaagaaaga caagtgacag gggcaatgga 420 tctcaggctc tgagataagt atatcagatg acactggtgg ctctaaggat attgcaatta 480 agcagctacc tgtagccagg tattctgctg ctcttggcct tttcccacgc atcgtctcgt 540 gtcttctccg aaagaccttg gaagataggc ctggaagaga ctgttgatgc cactttgaag 600 aaaagaacac tgagaactag aggagggaac actttgccca agattactca caaagccaag 660 acccagagtc cagcttagag aatagagttg ttcaggctgc caattgcaag ctcattcctc 720.
tacctcatac ttcctctgag gattttgaca aaatggatta attgggtgag ccttggagac 780 atgtgggaaa cacctgcaga cacaaaatga gtagtcatcc tgtctccctt tcaataggga 840 tctgaacagg tgttttgata cttgaaagat gtgcatgtca agtgagggtt tctttctgcg 900 atgttcaact ggaactctcc catcagtagt tacaattaga aatacctact gatggttagt 960 ctgaaggcca ttctcatggt cacctataca gtgtgtttcc ctgtgagcta gcagacacaa 1020 tgaccaggaa aaaacctatg aattccattc ttaggtttcc cagccaattg ctcccttctg 1080 ctttagaagt gactaggtac tgagagtaca aacactccca ctttataatg aaggcgtcat 1140 gtcacccctt cctttacagg tcctggggtc caggagaccc agaatgaagg tgtcagttgg 1200 gcatgaagtg ttatttagtg tccattcttg atccttctga gcacctacag ctggaaacta 1260 agcagatact ggt 1273 <210> 7 <211> 1663 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:406758.1:2000SEP08 <400> 7 agcctgacac atgaggtctt ggttctatga cttgaccaca tcctgagagc aaggtggggc 60 cctcgactgt cttgtatggg ccccaagcct ttcttgctgt gaacagcttc attctcagtc 120 ccctttcctg gctcaaaaat cgagcctagc aaaagaagag gcacgggaag gaaacgcccc 180 tccctcctcc tgcaggcagc cactcagcct gtgccttcag cttggtgccc tggtgatggt 240 tgctatggag atctaaagat agagcaggag tcaggagacc tgggtccctc tcccagcttg 300 tcccactgag cggctgccga tcacggtcca cccaccccag gaacctggca cccctatccc 360 aggaacccag tgcccctggg cagcgcactg cagttaatga attctgcctt caacagcctg 420 ggctctagcg tgctgcacca gcttgggcta gctacaggca gtcccagaat tggaatatta 480 agccatggaa tcttagagtt agacttttat agtcatagaa atgtactctt caccatatca 540 aagctgaaag ttcaggactc taagaaacat acagtgtgac agacttatcg tatacacggg 600 aaactgaagc ccagtgagac taaatgactt gcccagggta aaacagtcca tggcagagcc 660 agcactagaa gcctcctagc ttcaacctca tgtgccaatt ctgcatcagt gattttcgaa 720 ctgcgctcta caggaagcaa gggttctttg catagcagca gtgaaaggac agctccagat 780 ggatccccag tacccccttc aaccagagca gctgcatttt tatcccattc atatattggg 840 gttttgaatt atttttattt gtacaaaagg attttcctag ccactaaaaa aaatggcaac 900 aaatctctct~gctgtgtcac atttaataaa taattgtgac acatagctgg ggggtggtgc 960 tggaggtttc agaccgcctc acaggcagag ttccagggtc agagagcatg gagtactgtg 1020 tgtgaccttc ttccagaagc acgggcacag gagcatgtta aaggccctga aaagaccagt 1080 ggcaaagaaa ctcctttcat tttgtttaat ccagagtttt tcaagcttat ttaactatag 1140 aacacttttc tgtgggtttc gtagcctctt tctagcacag tatagtgagt gggaaaggcc 1200 ctgactgaga gtcaaagatt ctgagcagga accatgatct cttcctgcct agtatgtgac 1260 ttgagcaaga cacttttcct ctccccaggc ctctgaggtc tgcgagtttt cctccaccct 1320 ttcctctccc tcagtttgca catcctattg actcagctcc aaatagcggg ggcctgtcag 1380 gagcctgact ctgttcagac accagggaaa caacagcaca ccaggcagat gcagttatgt 1440 ccatcgggga acttacagcc tagcaaggaa ggcagcaatt caacctgtaa gtctaaaagt 1500 gatgggtgtc atgaaaaggt aagtgcaggg tgctgggaga gtggttggca ggggctttag 1560 cctagtctag ggagagccca ggggcacacc actgccagcg gggatagagg cttcaaaagc 1620 tttgaagtca ctcatattaa gagtgttgcc ggacacggtg get 1663 <210> 8 <211> 294 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:902957.17:2000SEP08 <400> 8 tggatttacc tccactttag taataatgac ataacacatt ctaatgctaa aaaatattca 60 ttattactac actttggctt gggagaggaa ttattttaaa tagacattgg tactttttga 120 acttgatagc taaagattct aaaatgcatg ttttatacta agttttaacc agtcaggaaa 180 attttatgta actagtgata gtttattttt ttgtatgaat tttgtttagg ctgcaatgtt 240 tagcttttgt taactcctca ctcttgctgt cttaagttca ttactatgtt taat 294 <210> 9 <211> 933 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:333179.1:2000SEP08 <220>
<221> unsure <222> 652, 657, 670, 821, 828, 853, 922 <223> a, t, c, g, or other <400> 9 ggaaggtgac tgtgaggaag gtgtgtgtcc accgagcact tggattcagc ttcttcattt 60 ccaacatgga agaaacttac accgactccc tggaccctga gaagctattg caatgcccct 120 atgacaaaaa ccatcaaatc agggcttgca ggtttcctta tcatcttatc aagtgcagaa 180 agaatcatcc tgatgttgca agcaaattgg ctacttgtcc cttcaatgct cgccaccagg 240 ttcctcgagc tgaaattagt catcatatct caagctgtga tgacagaagt tgtattgagc 300 aagatgttgt caaccaaacc aggagcctta gacaagagac tctggctgag agcacttggc 360 agtgccctcc ttgcgatgaa gactgggata aagatttgtg ggagcagacc agcaccccat 420 ttgtctgggg cacaactcac tactctgaca acaacagccc tgcgagcaac atagttacag 480 aacataagaa taacctggct tcaggcatgc gagttcccaa atctctgccg tatgttctgc 540 catggaaaaa caatggaaat gcacagtaac tgaataccta tctcatcaaa tgccagaccc 600 tagaagactg ttgcttcttc ttctaccagt gggttctcat tttcctccta anctaantat 660 agaatggtan actccctgtg actttccaaa ctgacaagca cacttttttc ctcccccctt 720 gaatcctcat ttaatgcaag aaccctcata ctcagaagct tccaaataaa cctttgatac 780 agattgctta atagtttggt caagtacctg cagccccaag ntcagagntc atgtccaatt 840 ccacattaat ganccataat gatttaaagt tttcttaaag gttctaactg aaatagacag 900 gaaacttggg ttagaaaatt tnaaagggaa aaa 933 <210> 10 <211> 2280 <212> DNA
<213> Homo Sapiens <220> .
<221> misc_feature <223> Incyte ID No: LG:406568.1:2000SEP08 <220>
<221> unsure <222> 445, 1360 <223> a, t, c, g, or other <400> 10 cagcctgcca cttgcctccc tgcctgcttc tggctgcctt gaatgcctgg tccttcaagc 60 tccttctggg tctgacaaag cagggaccat gtctaccttt ggctaccgaa gaggactcag 120 taaatacgaa tccatcgacg aggatgaact cctcgcctcc ctgtcagccg aggagctgaa 180 ggagctagag agagagttgg aagacattga acctgaccgc aaccttcccg tggggctaag 240 gcaaaagagc ctgacagaga aaacccccac agggacattc agcagagagg cactgatggc 300 ctattgggaa aaggagtccc aaaaactctt ggagaaggag aggctggggg aatgtggaaa 360 ggttgcagaa gacaaagagg aaagtgagga agagcttatc tttactgaaa gtaacagtga 420 ggtttctgag gaagtgtata cagangagga ggaggaggag tcccaggagg aagaggagga 480 agaagacagt gacgaagagg aaagaacaat tgaaactgca aaagggatta atggaactgt 540 aaattatgat agtgtcaatt ctgacaactc taagccaaag atatttaaaa gtcaaataga 600 gaacataaat ttgaccaatg gcagcaatgg gaggaacaca gagtccccag ctgccattca 660 cccttgtgga aatcctacag tgattgagga cgctttggac aagattaaaa gcaatgaccc 720 tgacaccaca gaagtcaatt tgaacaacat tgagaacatc acaacacaga cccttacccg 780 ctttgctgaa gccctcaagg acaacactgt ggtgaagacg ttcagtctgg ccaacacgca 840 tgccgacgac agtgcagcca tggccattgc agagatgctc aaagtcaatg agcacatcac 900 caacgtaaac gtcgagtcca acttcataac gggaaagggg atcctggcca tcatgagagc 960 tctccagcac aacacggtgc tcacggagct gcgtttccat aaccagaggc acatcatggg 1020 cagccaggtg gaaatggaga ttgtcaagct gctgaaggag aacacgacgc tgctgaggct 1080 gggataccat tttgaactcc caggaccaag aatgagcatg acgagcattt tgacaagaaa 1140 tatggataaa cagaggcaaa aacgtttgca ggagcaaaaa cagcaggagg gatacgatgg 1200 aggacccaat cttaggacca aagtctggca aagaggaaca cctagctctt caccttatgt 1260 atctcccagg cactcaccct ggtcatcccc aaaactcccc aaaaaagtcc agactgtgag 1320 gagccgtcct ctgtctcctg tggccacacc tcctcctccn cgggactcct ccactcccag 1380 agaaaaagct cattaccaga aacattgcag aagtcatcaa acaacaggag agtgcccaac 1440 gggcattaca aaatggacaa aaaaagaaaa aagggaaaaa ggtcaagaaa cagccaaaca 1500 gtattctaaa ggaaataaaa aattctctga ggtcagtgca agagaagaaa atggaagaca 1560 gttcccgacc ttctacccca cagagatcag ctcatgagaa tctcatggaa gcaattcggg 1620 gaagcagcat aaaacagcta aagcgggtgg aagttccaga agccctgcga taaaaacatg 1680 atctttagaa gaggatgcag aactgttcag tggtattaca tgaaatgcat tgtgagatgt 1740 ttctaaaata ccttcttcaa ttcaaaatga tccctgactt taaaaataat ctcacccatt 1800 aattccaaag agaatcttaa gaaacaatca gcatgtttct tctgtaaata tgaaaataaa 1860 tttctttttt atgtcgtgag atttgtattg gcaagaagca gttaatttaa agatgctctt 1920 cctatctgtg gatgtgttgg taactccgag ttgtaatgag ttcatgaaat gtgctgttat 1980 ttttgtaatc tcaataaatg tggattgaag ttttttccct ttttttaaag ccaaactaat 2040 atttttctgt gacttgatac atctgtcaga tttttgtaat ctcgataaat gtgtattgaa 2100 gttttttccc tttttttaaa aagccaaact aatatttttc tgtgagttaa tacatctgtc 2160 aggtgtgtat gtaacattac tggacattaa aaaaaattat tacattctca cccaaaaagg 2220 gtttgggtcc taagcatttg cctttctttg tttcctcttg ttcaagaaaa tctgattaga 2280 <210> 2l <211> 609 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:353203.1:2000SEP08 <400> 11 cgagagggcc ggagcagccg cagtcccggc gatcccgccg ccggtcgcec tcatacttcc 60 tcgtcactgc cttcgtttct ctttccaaca atcaagatga gccgtggcgg tagcgcgggt 120 ggtggtcaaa gttctctggg ttacctcttt ggaagcggtg agccccccaa accagcagtg 180 gcaccagctg taagtgctcc acctgctgct gcaggtgctc cacctgctga gaaaccacct 240 gctgcaaagc ctgatggcac cagtcagatt gctgctgggg ttaccagcca aaccaataac 300 taccacaggg ccgacggtca gaacaccgga aacttcctta cggaccgtcc ttcgaccaag 360 gtccacgctg ctcctggcgg tggctcttcc ctgggatacc tgtttggtgg caactgatgc 420 cgctcaccaa gctatcaccc cccactgtcg ccgcatgctt tttctgaatc gtgaacagac 480 cgttgtcatt tcatgtgtac ccaaacctcc cgtcccgcgt gggcccgtaa gctgcgccta 540 gatttcaggg ctaatcgtgt gcctgaaccc tcatcataag tcgtctctgt acccagcttc 600 tcgtttcgt 609 <210> 12 <211> 504 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:061277.1:2000SEP08 <220>
<221> unsure <222> 475 <223> a, t, c, g, or other <400> 12 attttttgat agacaccatt gcaaaacaac ataaagctgt tttgctcaca ggagagcagg 60 gaactgcaaa aactgtcatg gttaaggcct atttgaaaaa atatgatcct gaagtacagc 120 tatccaaaag tctaaacttt tcatctgcca cagaaccaat gatgtttcag agaacaattg 180 aaagctacgt ggataagcga attggaagca catatgggcc accaggaggg agaaaaatga 240 ctgtatttat tgatgatatt aatatgcctg tgattaatga gtggggagat cagataacta 300 atgagattgt gcgacagatg atggaaatgg aaggaatgta cagcttggac aagcctggag 360 acttcactac tattgttgat gtgcagctca tagcagcaat gatccaccct ggaggtggtc 420 gaaatgatat tccacaacgt ttaaaaagac aatttactgt gtttaattgt acatngcctt 480 caaatgcttc aatagacaaa attt 504 <210> 13 <211> 470 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:170666.1:2000SEP08 <400> 13 gtgaaacaca ttcatcttca tcagaaagag cctcatcttt aattgcataa aacagaaagg 60 ttggctcgca cttccctcgg ttggtgactc cgggcgcgtc gaagatcttg tacctgtcgt 120 tcgcagtggc tcactttccc aagccatggg cagcaggaag aaggaaattg ccctgcaggt 180 caacatcagc acccaagagc tttgggagga aatgctcagt tccaaaggac taactgttgt 240 tgatgtctat caaggctggt gtggcccctg caaacctgtg gtgagcctct tccagaagat 300 gaggatcgag gtcggcctgg accttctgca ctttgcatta gcagaggcag atcgtcttga 360 tgtcctcgaa aagtacagag ggaagtgcga gccaaccttt ctgttttatg caattaaaga 420 tgaggctctt tctgatgaag atgaatgtgt ttcccatgga aagaataatg 470 <210> 14 <211> 984 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:311197.1:2000SEP08 <400> 14 gctctccacg tgcgcgactg cgaggctgga cgctacgggc tcctggaaag gagttaagat 60 gccaaatttg atatctggag cacctggaac cttgcagagt gttttgaaga ggaggttaca 120 atgaaaaaca aaacaaaaaa gaaattttgc tctgcaagtc tactgacaag tcccgtttcc 180 ttcccacatt ccaatctatg tctgcctttg tgttcagcag acaccagcat ttgccacaat 240 gctgtcatcc actgacttta catttgcttc ctgggagctt gtggtccgcg ttgaccatcc 300 caatgaagag cagcagaaag acgtcacact gagagtatct ggagaccttc acgttggagg 360 agtgatgctc aagttagtag aacagatcaa tatatcccaa gactggtcag actttgctct 420 ttggtgggaa cagaagcatt gctggcttct gaaaacccac tggaccctgg acaaatatgg 480 ggtccaggca gatgcaaagc ttctcttcac ccctcagcat aaaatgctgc gccttcgtct 540 gccgaatttg aagatggtga ggttgcgagt cagcttctca gctgtggttt ttaaagctgt 600 cagtgatatc tgcaaaatcc tgaatattag aagatcagaa gagctttcct tgttaaagcc 660 gtctggtgac tattttaaga agaagaagaa aaaagacaaa aataataagg aacccataat 720 tgaagatatt ctaaacctgg agagttctcc aacagcttca ggttcatcag taagtcctgg 780 tttatacagt aaaaccatga cccctatata tgaccccatc aatggaacac cagcatcatc 840 caccatgact tggttcagtg acagcccttt gacggaacaa aactgcagca tcctcgcatt 900 cagccaaccc ccccagtccc cagaagcact tgcggatatg taccagcctc ggtctctggt 960 tgatacagcc aagctcaatg cagg 984 <210> 15 <211> 1004 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:220655.4:2000SEP08 <400> 15 gtcttggtta ccgcggcgtc aggcggggga ggcgctcaca gctggcctaa caggtgaagg 60 acggcgcagg tgggcggagg cctgtccgcc aaggaccgcc gggtccgcct gtgcgctggg 120 aaggcccgcc ccctagcggc cgatctttag agtacggagg gcagccccca aaggcctccc 180 atccctgtcc ccgcccctgg gcccctggac tcactttgat ctcgatctgc tcctccatct 240 ccttgctctt catggctgcg tactccttct ccagcctgca gatcgggagg gccccgtggt 300 tactgtcatg ccctcggggg tccccccttc ctaccagtac cctggttgcc cagcaggcac 360 cgacctcttc atcttcttgg ggttgtactt gacctggtag gctttgagga ccagcttgtc 420 cgggcagctg tcgaactggt gggggatcac tctctggaag tactgtgggg acacagccgg 480 tcacctggtc accaacatgc aggccctgac caccgggggc cgcccgagcc ctgttgccct.540 ggaggggggc aggaacgggt ctgcccgggg tgtcgccatg tcctcaacgc cgtgtcctca 600 gtgtttgtgg agcaatggaa agactgagcg tgaggggagg gaatggggga ctgcctgcag 660 ccaaagcctt agtttccaga agaaaagctg gcagatgctg gatgtggtgg ctcattcata 720 taatcccaat gatttaaaag cctgggacat cccctccatg tccagctgca tcagctccgc 780 ctggttcacc tgcagcaggg cgaggcccac tcggaacacg atctccagcc cctcatacat 840 gaagatgtca aagacccggg tggcgacggg gagtgggaag gtggtcagga acagtgtgag 900 gaaccaggac gaggcataca tggatgtgtg gaagctttgg gaacggaagt gggtgttgag 960 gtctgggagc tgctcctgca gccatgtact cgaactgata gatg 1004 <210> 16 <211> 868 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1001893.1:2000SEP08 <400> 16 caggcctggt cagacatggg caaggagcac aagtcagaga agcacctcta caaagagtat 60 gtggaaaagc ccttgaagct ggtcctcaaa gtaggaggga aagcagttac tgagctctcc 120 acgggcagtt tggagcactg ctccagcctc ttcaaagaca aaaacaatca tgacaaacac 180 aaggacagaa agtggaaaaa gagaaagaaa ggagagaagc cagttctggg ggaagaaaag 240 gggagaaagc agaattgaag aggacaaaaa taagcgagat caagaccatg tggagaatga 300 ggcagaaaaa gacttccagt gtcatgcccc tatgagatta gacttgcctc ctgagaagcc 360 tctcacaagc tgtttatcca aacaagaaga agtagaacag atgtcccttc aagatgtttg 420 tttgtttgag acagggtatt gctctgttgc ttaggctggc atgcagttgc acaatcatat 480 gtgcaattgt agcttgttga gcacccgatt ttattgctgt ttggggcagt acttgtagcc 540 tgcatggacc ttgggagact gaacaaaggg ggtgtaacgc gggaataaaa gacaaagaca 600 aaagagtata attggaagaa ggggtcgggg gcaccttgcc tctagtggac agggtccttg 660 agctttttca gccctctgaa tgtattaggt aaaagagata acgagaaaga gagggtgatt 720 gttgagtaat tatcagtcag cctgtttggt tcacagcagg cttgtgagac tgcatccttc 780 gaacaatagg tgcaggcttg tgagactgca tccttcgaac aataggtgct agatttccca 840 gtagataact tcaaggagcc cagcgcca 868 <210> 17 <211> 2545 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:004335.1:2000SEP08 <400> 17 ctctcttctc gagctctctt ctcgaggttc tagatcgcga cggcggctgc agctggagcc 60 aggcgctcgc ccgtccgccg gttggctcgc cgggacctcg cgcaccggcg gcagagtccc 120 ttgcgtggat tggcaagcga cgccccacct gccccgagct caccattttc tttcgcgctg 180 gctgcagctg acccggcgaa gggagccgac cgggccctgg gctggaggta aaaccccacg 240 gaaagaacat gaggttccct tggaaatcat tcaagaggaa gatggaaggg gctgtttaga 300 agagcttaaa agctacaggc tgtaagactg gggcctgagt gctggcagtg gaaaacactg 360 ttgggctgtg atctctccct gaaaagttcc aggtgccttt ttccttcctg caaaagaaag 420 gaagcgaaag agaagaccat gtccatagcc ctgaagcagg tattcaacaa ggacaagacc 480 ttccgaccca agaggaaatt tgaacctggc acacagaggt ttgagctgca caaacgggct 540 caggcatccc tcaactcggg tgtggacctg aaggcggctg tgcagttgcc cagtggggag 600 gaccagaatg actgggtggc agtacatgtg gtggacttct tcaatcggat caacctcatc 660 tatggcacca tctgtgagtt ctgcaccgag cggacctgtc ctgtgatgtc agggggcccc 720 aaatatgagt atcggtggca ggatgatctc aagtataaga agccaacagc gctgccagct 780 ccccagtaca tgaaccttct tatggattgg attgaggttc agatcaacaa cgaggaaata 840 tttccaacat gcgtgggtgt tcccttccca aagaacttcc ttcagatctg caagaagatc 900 ctgtgccgcc ttttccgggt ctttgtccac gtctatatcc accacttcga ccgggtcatt 960 gtgatgggtg cagaggccca tgtcaacacc tgctacaaac acttctatta ctttgtcaca 1020 gagatgaacc tcatagaccg caaggagcta gagcctttga aagaaatgac gagcaggatg 1080 tgtcactaat gctccacctc accctttgga agaaaggaaa gctgtttcct cctggtgccc 1140 tgagcgggca ggaggtggac caccctggct gaaatgacac acctactccc aggaacagca 1200 gaggtggagg caagcagtga ctcctgagag acattcccca ctcactttgt gtgctcttaa 1260 ccttctgagt gctgctagcc cagacctgtg gacgaggcag accacaacgt gaaagaagga 1320 ccagcccctt gaccgttctg gctggggaat tgtccacgag gaagcctctg cacttccaca 1380 catggcacag ttctgcctgt gacctgccgc ctaagcttta ctggaattca ggttttgaga 1440 ctgagatgcg tgttcgtatt tttccactta tctgtcttgt cagctggccg acttctctgt 1500 gattggtttt ttaagtgccg ggtgaatttt ggacctctgg atgtgcagca agtttttatg 1560 caataagcct tcctttcagg tctctaaaag ctcctgctct gatctgtggt ttaacactgt 1620 gcagggctgt ggagctctga gagacctgaa cccctaccca tcccctgcac ctccctactc 1680 tccctgccga ggcgtccata gcatttccct aataaatagt tttatcaggg acactccatg 1740 gggtggcttg tctctgcccc aaacagggtc ttcacgttct aactgcaggg aagagactgg 1800 ttactagcgt aaagctgaca agttaccagt tcacctgatc agaatgtatt ttttataacc 1860 accatcattc cttgtctctt cagtggaaga tattctttcc tgtttcccag aagagagaaa 1920 taaaagtcct aaataactaa gaatgatcag cgggagcgtt gggcatgatt actgcagtgt 1980 ttgttcttta ttaaagacag ggagtcgtgg ctgtctctac ataatactaa catttcagtg 2040 aaaaaagtac agttggttat ttggtacgtg tagatttaac acccagacgg ctgacttgta 2100 accctcccca ctagccttct gagcatttaa acccagccgt cattctctcc ccactccacg 2160 ctccccactc ctctgccacg ttatgttacg gcacaaaatt aatttctgcc cctgtgattg 2220 ggccacggtt gccaaggtaa cagtggagct ggagctaact tccttctttc atcctttcca 2280 atttttctat tccagaagac agtcagaata atgcattctg tactacatcc tgccttttga 2340 aacctaaatg agttttcgtt gatgaaatgt tgccttctct gattcattca caaaactgtg 2400 gtggttctga ccacctgtga cgaggggggt cataatactt ccagtgatcc ttttaattta 2460 gcaaaatatt tgtcggtgga gggaagtaga taagaatgta ttagtgtatt ttaaagtaat 2520 aatgattaaa gaataactaa atgaa 2545 <210> 18 <211> 393 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:213092.6:2000SEP08 <220>
<221> unsure <222> 30 <223> a, t, c, g, or other <400> 18 catccctggc caggaccccg ggggccccan ggggactgtg ccccaggccc ctccctcgtg 60 gaccgaccgc cttcctcgct tctccttggc ctggagaggt tccttccaat ggccctgagc 120 tgggggagac agacaaatgc gacaaggacg ggaggagcag ctggagggac cgacatttga 180 cttaccaagt agctctttgc gcgccttctt ctgcagcttc agcgtgtccg acgacttctt 240 tttgatctca tgccgggctc gtttgtactc tttcgcgtgg tccttgtcca gctggttggc 300 cgccttcttc cagtcctcga tgcgctcctg cagcgggttg atgaggctct ccagcagtgc 360 gttggtgaac tgccgcagct tggtctcgat get 393 <210> 19 <211> 676 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:407570.5:2000SEP08 <400> 19 agagtcttct ggctgtgctg cctcctctgc ttttaatctt ctgtggatat ttctccgatt 60 tcccccaaaa gcccacagat cctgggggaa gccaccccat tcggccaccg atcatggaag 120 aaagtattac tttttattta ccaaacattt taaagatgtt ggaagatcca tatgctgcct 180 ggaggctgtt gtttctaggg acacaagtat ccagcctata ttgttacaat tttttttcaa 240 gaactgccgt cttctttgcc tgcactaatg gaacatcatc ttcagcgggc tatttcagca 300 cagcaggtgt atggcgagaa gagggataat atggttatac cggtcccaga ggcagaaagt 360 aatattgctt actatgagtc tatatatcct ggggaattta agatgccaaa gcagctcatt 420 cacatacagc gtaagtaatg attctcttaa tgattgtatt ttctatattt ctcttattat 480 gtaacttgac agatttttat ctcttcagga gcgtttttgt tatttgtttc attgaccagc 540 atcagcttaa gagttagtag agtccatttt caacttttaa aatgatattt gagatatctg 600 acaagaaaag atagcattta ttattctaca ttttttgttt cattccagca tacaatctta 660 tgctgcttta gtcaag 676 <210> 20 <211> 988 <212> DNA

<213> Homo Sapiens <220>
<221> misc_feature <2-23> Incyte ID No: LG:337835.8:2000SEP08 <400> 20 cagcagtcag aaaagaggtg caggggcccg ggctgggaca gtgaagagtg ctgggcagtc 60 tgtggtcctc tgtatctcaa ctttttcatc ttaaaaaaac aaatagggtt gtgtgtgtgg 120 ctggtggtca taaggtcctt tctggctcta ataacctgag cttctgttat gaagctggga 180 cccttagagc ctcaggatga tcctctgttt gtttgtgaag ccccaatcag gtgctaagca 240 ccatagtggc acttagctga agctcctctg taactcctgt gggccctgcc ttgcccaccc 300 ccgacagctg ctgcagtgct cctgagcagc acaggcctga tggagcttct ggagaagatg 360 ctggccctca ccttggcaaa ggcagattct cccaggactg cactcctctg ctctgcctgg 420 ctgctcactg cctccttctc tgcccagcag cacaagggca gtttgcagaa ggaccctcta 480 ttgtcccagg cctgtgttgg ctgcctggag gccttgcttg actacctgga tgcccggagc 540 ccagacattg ctctccacgt ggcctcccag ccttggaatc ggttttgctg tttaccctct 600 tggatgctgg agagaattcc ttcctcagac ctgagatttt gaggctcatg accctgctcc 660 agagcatggg acacctggct gaccacagca tggcccagac cctgcaggcc tccttggagg 720 gccttccccc tagcacctcc tcaggccagc cacccctgca ggacatgctc tgcctgggag 780 gggtggctgt atccctgtcc cacatcagaa actgatcctc aggacttgaa ggcccagaag 840 tggagagaga atgagacctg gagacaaagg gcataattgt tggggaaatg gatgacagct 900 gaagctattc atatggagcc atatactcta ttgttgaaat agaataagga aataaaatga 960 tacactcaca taaaaaaaaa aaaaaggg 988 <210> 21 <211> 470 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1099283.1:2000SEP08 <400> 21 gcccggctgg ggacccgcgc acctgcagcg cccgctgctc ggccctgcat cctgcctggg 60 catcctgcgc ccggccatga cggcgcactc attcgccctc ccggtcatca tcttcaccac 120 gttctggggc ctcgtcggca tcgccgggcc ctggttcgtg ccgaagggac ccaaccgcgg 180 agtgatcatc accatgctgg tcgccaccgc cgtctgctgt tacctcttct ggctcatcgc 240 catcctggcg cagctgaacc ccctgttcgg gccccagctg aagaatgaga ccatctggta 300 cgtgcgcttc ctgtgggagt gacccgccgc ccccgaccca ggttcagctc gaagatattt 360 aaaaaccact tgctccatga acctttccat aagatcccag tcttcaatga ttccatgtcg 420 tatcggccac tggaggaaga gacaccagag ttgtcaagcc tcagttcaca 470 <210> 22 <211> 548 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:401274.2:2000SEP08 <400> 22 caggctgggg catcctcgcc ctggctcttt gagcccggac cagacaggtg ctgggaatac 60 agcaaggaat tagaccagtt ccctgctctc tggtatggtg ggacagatac taaaaagaga 120 tgtgataatg gatcatcatg tttctaccat caagcctcga agaatccaaa accaaaatgt 180 cattcaccgt ttggaacgcc ggcggatcag ttcaggcaag gcaggtaccc actggcacca 240 agtccgagtg ttccatcaga atgtcttccc caacttcaca gttgtcaacg ttgaaaagcc 300 tccttgtttc ttgcgtaaat tctcacctga tggacgctac tttattgctt tttcttcaga 360 ccagacatct cttgaaatct atgagtacca gggctgccag gcagcagagg acctactgca 420 gggatacgaa ggagaaatcc tgtccaatgg caatgaccag cggtcagtga atatccgggg 480 ccggctcttt gaacgctttt ttgtcctgct gcacattacc aatgttgcgg ccaatggtga 540 gcacctga 548 <210> 23 <211> 2592 <212> DNA
<213> Homo Sapiens <220>
<221> misc feature <223> Incyte ID No: LG:222880.1:2000SEP08 <400> 23 cgtcgcccaa ggtcgcgggc cgcttgggga gtcagcagcg cgccaggccc cttcgggccc 60 cacacgcatt aggtgccttc tagaagggta cggagtgaac gcgggcggcg gcgggaccga 120 ggcagcgccc agtttgtaac cgccgcgccg cccgtgcccg cgcgcgccac accccagcgc 180 gcttccggcc gggccacgtg accgcgcgtg cacgtgttcc ggcctctccg cttcgccgct 240 ccgaacctcc tcctggtcgt cccggcattc gtccacgcgg agccggcttg ggcggggccc 300 gggaggcggc ggccggagaa gccgcggaga cgcgagcgcc gagcgtcgcg agggagcagg 360 cccgggcagg caatgcggcg gcctccgcca tgaaccccag gggcctgttc caggacttca 420 accccagtaa gtttctcatc tacacctgcc tgctgctctt ctcggtgctg ctgcccctcc 480 gcctggacgg catcatccaa tggagctact gggccgtott tgcccccata tggctgtgga 540 agcttctagt cgtcgcaggc gcctccgtgg gcgcgggcgt ttgggcccgc aaccctcgct 600 accgcaccga gggagaggcc tgtgtggagt tcaaagccat gctgatcgct gtgggcatcc 660 acctgctgct gctcatgttc gaagtcctgg tctgcgacag ggtggagagg ggcacccact 720 tctggctgct ggtcttcatg cctctcttct tcgtgtcccc cgtgtccgtg gctgcctgcg 780 tctggggctt tcgacacgat aggtcgctgg agctggagat cctgtgctcg gtcaacatcc 840 tgcagttcat cttcatcgcc ctaaagctgg acaggattat tcactggccg tggctggtgg 900 tgtttgtgcc cctgtggatc ctcatgtcgt tcctttgcct ggtcgtcctc tattacatcg 960 tctggtccct cctgttcctg cggtccctgg atgtggttgc cgagcagcgg agaacacacg 1020 tgaccatggc tatcagttgg ataacgattg tcgtgcctct gctcactttt gaggtcctgc 1080 tggttcacag attggatggc cacaatacat tctcctacgt ctccatattt gtcccccttt 1140 ggctttcctt actaacttta atggccacaa catttaggcg aaaggggggc aatcattggt 1200 ggtttggcat tcgcagagac ttctgtcagt ttctgcttga aattttccca tttttaagag 1260 aatatgggaa catttcatat gatctccatc acgaagatag tgaagatgct gaagaaacat 1320 cagttccaga agctccgaaa attgctccaa tatttggaaa gaaggccaga gtagttataa 1380 cccagagccc tgggaaatac gttccccccc ctcccaagtt aaatattgat atgccagatt 1440 aaactcctag agaggaccca ggcacacaca gactccactt ggccttcgcc tcttgttcat 1500 tcatcccaaa cctggaaatg gaaacaggct tcaaacactc gtctcacgcc gtgtttgaga 1560 tcaccgcctc atcagtatgc atcatagatg gaggtggttt cagtatgtgg gtgtgtgtgg 1620 tgtgtacctg ggtaagagac ttgctttcca ggttcgcact ttcaggtgta gctgggggca 1680 gtaagtcgaa ttgttttagt aggtcctcaa aaggaataac cacacagctg tttgtttaaa 1740 tgctactgta cctatcaaaa ctattgttta aaaagtattt ttatacactg ctaatctaaa 1800 attgtatttc agattgtgcc tgtcataaca atagcaaatg taaaaagttc tctttcccac 1860 cacttgttta taaacctcat agttgatatt tttagtgttc ctactgttaa aatactctct 1920 ccttgggctt tgctgatact ggtctttaat attctgatag gtgaattttt ctaatggaat 1980 gaacccatgc atatatagta tttatatgaa tattttagca gtgtaatatg ttgaattcta 2040 gttctctgca ttaccattat tacgttaaag tattttttaa agcttaggtg tgaagatatg 2100 tgtctattgc agatgtcctt gaaaactgca taaaacagta tgtgcctggt gtggatctta 2160 ccaaagtact aggcatgaat gtagggactg caaatcccat gggtcttaat atttaggtgt 2220 tagtaaccaa ggtctctggt agtacccgtt agtagaggaa gaggccactg cccttgggaa 2280 cttgtgacag gctctagtgt ggtaccaggc cataaagtga cactgttatt tagcaacttg 2340 aatttttcca cacaggtagt aactgtgtgg aaataagcaa caagtggttt gtccatttct 2400 aagaatctta aactattagt tggctgtagt gtgaagcatt acttgtcatt ggaaagatgg 2460 agagagtggc cttaaccgga agtggtcagt agaagcaggt gtcattttaa gggccaaact 2520 ttaatctgtc agcaataggg aaacaactgt tcaaattatc tttgtagata agaacagtgt 2580 ttcttttttc tt 2592 <210> 24 <211> 1661 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:406389.1:20005EP08 <220>
<221> unsure <222> 677 <223> a, t, c, g, or other <400> 24 gacgcggggc gccagctgcc aactgtgcgc gcgcggagct ccccggcggt gcagtcccgt 60 cccggcggcg cgggcggcat gaagactagc cgccgcggcc gagcgctcct ggccgtggcc 120 ctgaacctgc tggcgctgct gttcgccacc accgctttcc tcaccacgca ctggtgccag 180 ggcacgcagc gggtccccaa gccgggctgc ggccagggcg ggcgcgccaa ctgccccaac 240 tcgggcgcca acgccacggc caacggcacc gccgcccccg ccgccgccgc cgtcgccgac 300 aacgcctcgg ggaacggccc ccctggcggc gcgctctaca gctgggagac cggcgacgac 360 cgcttcctct tcaggaattt ccacaccggc atctggtact cgtgcgagga ggagctcagc 420 gggcttggtg aaaaatgtcg cagcttcatt gacctggccc cggcgtcgga gaaaggggtc 480 ctgtggctgt ctgtggtctc cgaggtgctg tacattctgc tgctggtggt tggcttcagc 540 ctcatgtgtc tcgagctctt ccactccagc aatgtcatcg acgggctcaa gctcaatgcc 600 w ttcgcggctg tcttcacggt gctctcaggc ctcctgggaa tggtcgccca catgatgtac 660 acgcaggtgt tccaggncac cgtgagcctc ggtcctgagg actggagacc ccattcctgg 720 gactacgggt ggtccttctg cctggcgtgg ggctccttta cctgctgcat ggcagcctct 780 gtcaccacgc tcaactccta caccaagacg gtcattgagt tccggcacaa gcgcaaggtc 840 tttgagcagg gctaccggga agagccgacc ttcatagacc ctgaggccat caagtacttc 900 cgggagagga tggagaagag ggacgggagc gaggaggact ttcacttaga ctgccgccac 960 gagagatacc ctgcccgaca ccagccacac atggcggatt cctggccccg gagctccgca 1020 caggaagcac cagagctgaa ccgacagtgc tgggtcttgg ggcactgggt gtgaccaaga 1080 cctcaacctg gcccgcggac ctcaggccat cgctggcacc agcccctgct gcaagaccac 1140 cagagtggtg cccccagaac cctggcctgt gtgccgtgaa ctcagtcagc ctgcgtggga 1200 gatgccaggc ctgtcctgcc catcgctgcc tgggtcccat ggccttggaa atggggccag 1260 ggcaggccca agggaatgca cagggctgca cagagtgact ttgggacagc agccccggac 1320 tcttgccatc atcacatgag ccctgctggg cacagctgcg atgccaggag acacatggcc 1380 actggccact gaatggctgg cacccacaag ccagtcaggt gcccagaggg gcagagccct 1440 ttggggggca gagagtggct tcctgaagga gggggcagtg gcgcaggcac tgcaggggtg 1500 tcacacagca ggcacacagc aggggctcaa taaatgcttg ttgaacttgt tttcttgcgg 1560 tgtatggagg ccagttgctc tgtgggctgt ggctggcctg tcattgaccc aacccattac 1620 tcctcaagga ggctgaaggt gacagcagag actgtgcaga g 1661 <210> 25 <211> 1613 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:055461.1:2000SEP08 <220>
<221> unsure <222> 1554 <223> a, t, c, g, or other <400> 25 tcaacttgaa atgccaagca ttaaatgagc cacaaagatt gaattcccat tatccttgaa 60 tcagagcaag cctgtcgtgc agccatgagt tagtggagaa aaatccggag ttagagaaga 120 ttataaatgg cagagccatt taactgtggt tagctgttgg attctgatac tttcttaaaa 180 atacgttctt gcaccaacat cttcattggg aacagttcag aaaaagcaaa gaggagagcc 240 aacattcaca tttaccatgg ctataccaat aacagtgctt gactgtgacc tcttgctata 300 tggccgtggt caccggacat tggaccgttt taagctggat gatgtgactg atgaatactt 360 gatgtccatg tatgggtttc cacggcagtt catttattac ttggtggagc tcttgggggc 420 gaatctttct aggcctactc agcgatccag ggctattagc ccagagacac aggtccttgc 480 agcattgggt ttttatacct caggttcctt ccagactcgg atgggagatg ccattggaat 540 cagtcaggcg tctatgagtc gttgtgttgc caatgtcact gaagcacttg tggaaagggc 600 ctcacagttc attcgctttc cagctgatga agcctccatt caggctctga aggatgaatt 660 ctatgggttg gcagggatgc catgggtgat gggggtggtt gactgtatcc atgtggccat 720 caaggcacca aatgctgaag acctctccta tgtgaaccga aaaggcctgc attctttaaa 780 ctgcctgatg gtgtgtgaca ttagagggac actaatgacc gtggagacaa actggcccgg 840 cagcctacag gactgtgctg tgctgcagca gtcttccctc agtagtcagt ttgaagcggg 900 tatgcacaaa gatagctggc ttctgggtga cagttccttc tttcttcgaa cctggctcat 960 gaccccactt cacattcctg aaactccagc agaatatcgc tataacatgg cccattctgc 1020 aactcacagt gtgattgaga agactttccg aaccctctgc tcccgattcc gctgcctgga 1080 tggatccaag ggggcactgc agtactcacc agagaaatcc agccatatca tcttggcctg 1140 ttgtgtcctc cacaaacatc tccctggagc atgggatgga tgtttggtcc tctccaatga 1200 caggacccat ggaacagccc ccggaagagg agtatgagca catggagtcc ctggacttag 1260 aggctgaccg tattcgtcag gagctaatgc tcactcattt tagctaatgt agaaggtgga 1320 gaggagggat acttcccagg agttgtgaca gactttcctc ctcatcacct tttacacagt 1380 tccatcatct agcatgactg agtatacaga tacttgtcat aaactgacat ttaatatgtg 1440 tgttttggta aggttggggc tatgccagaa tatcttgatt catttgcata tgcattaatt 1500 aaactgaaac caagacagcg gctccctact atccagtgaa ctctaggttg agtnccacta 1560 atttgaaagc tcagtggttg caaacattta tgactgtgcc tacaaagtca tag 1613 <210> 26 <211> 658 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:979059.5:2000SEP08 <400> 26 gctactgaca tgcagaggaa gagaagcagc gaatgccttg atggcacatt gactccttct 60 gatggacaga gtatggagag agctgagagc cccacaccag gaatggccca gggaatggag 120 ccagatggct acaaggtagt attcgtgcgc cggagcccgc tggtgctagt ggcggtggct 180 cgtacgcggc agtcggcaca agagctggcg caggagctgc tctacatcta ctaccagatc 240 ctaagccttc ttaccggtgc gcagctgagc cacatcttcc agcagaagca gaactatgat 300 ttgcggcgcc tactctcggg ctcagagcgc atcaccgaca acctgctgca gctcatggca 360 cgagacccca gcttcctgat gggggcggca cggtgcctgc ccctggcggc ggccgtgcgc 420 gacactgtga gcgccagcct gcagcaggcg cgtgcgcgca gcctggtctt ctccatcctg 480 ctggcccgca accagctcgt ggcactcgtg cgcgcagcct ggtcttctcc atcctgctgg 540 cccgcaacag ctcgtggcac tcgtgcgccg aaaggacaat ttctgcaccc atcgactgac 600 ctgtcttcac tcattagttc tcctcgtctt tcgcgaggcg agctggagcc gtgtgctg 658 <210> 27 <211> 1950 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:399238.1:2000SEP08 <400> 27 ccgggcgctc gggcaggtat tgtccgtccc tccgggcttt gtagaatcgt cgccggctta 60 cctggccgtg ggcgcgtcct ggccgctgca gcccggagca gggtgcggcg gcggcggcgg 120 cggctgatgg tgtccccggt cactgtggtg aagagtgaag gacccaaact ggtgccgttc 180 ttcaaggcca cctgcgtgta ttttgtgctc tggctgccct catctagccc atcgtgggtc 240 agcaccctca tcaagtgcct gcctatcttc tgcctctggc tcttccttct ggcccatggc 300 ctgggattcc tgctggccca ccccagcgcc acccgcatct ttgtggggct tgtcttctct 360 gctgtaggtg acgccttcct catctggcag gaccaaggat acttcgtgca tggtctgctg 420 atgtttgctg tgacccacat gttctacgcc tcggcctttg gcatgcagcc actggctctt 480 cggacaggtc tggtgatggc agcgctgtcg ggcctgtgct atgccctcct ctacccatgc 540 ctctcaggtg ccttcaccta cctggtgggg gtctatgtgg cccttatcgg cttcatgggc 600 tggcgagcta tggcagggct gcggctggcc ggggcagact ggcgctggac agagctggca 660 gctggcagtg gtgcactctt ctttatcatc tcagacctga ccatcgccct caacaaattc 720 tgttttcctg tgccctactc tcgggcgctt atcatgtcca cctactatgt ggcccagatg 780 ctcgtcgcct tgtcagctgt cgaaagccgg gagcctgtgg aacactacag actgaccaag 840 gccaactgag gtgccagggt ctggtcaccc ctctctcctc ctggggctgg ggcccagatc 900 ctggggacct gcaggagctg gatcaggatg gctgcagtgc cagcctgggg cagcaggtac 960 tgcctgagga atttgcaagt tcgtgtgggg aggctggaaa aggatctccc tagcagaact 1020 cgtggttcag gacaatgctg agagctaaaa gagccagcct aatatcagac tggagccaga 1080 agtagacatc tccccacctc taccctatca ggactttcaa aacccccctg gaaggtgatg 2140 gtgctcagct tcttgacacc cccccaccca cttcccctac caggtggaag agtctgactc 1200 catgtgttat gcctaggacc aatggcagtg ctgggttcac ccactcctcc cctttttcat 1260 ctgcacaaag ttgagggaaa cgggagaatc tgtgctgaga agactcagac ccaggagccc 1320 ctttcacagg cccctagttg ggaagactgg atgagagtgg agcctccgtt tcttttccct 1380 cttctatcct tgttacttga acaatctcag tctctaagtg gtgggtgggg acatgaagag 1440 gtgtgggtcc aggttaggca ggagagagaa cttctttggt ctcggagttt ggggtctcaa 1500 gaattcaagt agccccatct ctctctcggg caagcccaaa gctcaggtcc catacgctac 1560 ccttagatcc tatccccagg gctagggtga accatgccaa aggaaggggc cagcttctct 1620 gtgtgtgtgt gtagcctgtc tcctagtctg cctatgtctt tctctgctat atgtttctgt 1680 cctgctgtct gtcaaaagtc tcacagagag agggcctcag ggagctgctg aggggtgctg 1740 agcctggctc agggagctgg gacccctccc ctccaacaca catactcaca gtgctttcct 1800 ccttgtccct cctacactag gagcaagagg agggggctcc aatgacactc tggggtttta 1860 agacccaagg cacattcaat gcaaggggag caaggatggg acaactccat cttctgctgc 1920 ccatgtgaaa aataataaaa atcaagagcc 1950 <210> 28 <211> 572 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1382945.7:2000SEP08 <400> 28 tatttaattg gaaattttaa ttcgctccca gtgaatcaat agagtgtcat ttaggaggat 60 ttcctaatgc tggctcttta attctagaga tattatatgc ctggtaagtc aagggttgat 120 tttcagaagc tccattattt tataagaatt gtgtgttttt tatttgaaac atagtatata 180 gatcgtttaa atgaaatttc acaaaactat tctttttttc ccatcactca gggttatgtg 240 cttcacatga tcactactgc agcagaatgg tctatgtcat tttccttctt tggttttttc 300 ctgacttaca ttcgtgattt tcagaaaatt tctttacggg tggaagccaa tttacatgga 360 ttaaccctct atgacactgc accttgccct attaacaatg aacgaacacg gctactttcc 420 agagatattt gatgaaagga taaaatattt ctgtaatgat tatgattctc agggattggg 480 gaaaggttca cagaagttgc ttattcattc atcatgaaat atttcaacca cttaatcaag 540 gctgacagta acacatgatg aatgctgata at 572 <210> 29 <211> 2638 <212> DNA
<213> Homo sapiens <220>
<221> misc feature <223> Incyte ID No: LG:1383610.3:2000SEP08 <220>
<221> unsure <222> 1998 <223> a, t, c, g, or other <400> 29 ataattatgg cggccacagt tcattggccc tttcaagtag aaggaatagt ttttgaccat 60 aaaaagtcaa actagaaagc cattaatgtc caacttccag agtagatttt ctgccttgga 120 gcagaagagg tgtgtgccga gttttatgtc tggcaaataa tgttagaggc caaacttggg 180 , .
ccctgcagct ccctcactcc acctggcatt tgccaggtac tgctctgggc tctggggaca 240 ccgcggtaaa caatatcctg gccctcatgg gagccatctt ctactcaggg gaagcattgg 300 ataaacaggt ttcgttgagt gccctaatca gggtactgtg ttagagtagg agggaggaag 360 gcagaaggaa ggatgccacc ttgaatagca tggtcacaga aggcctgtct gaagaggagc 420 aatttgagtg ggaccttgaa ggtgagaagg agccaagggg gcagagctgg gaggacattc 480 caggcagagg gaatcccaag tgcagtcctt aaggtgagga agccagcagg aggtggcgtg 540 tctctagatg aggtcaggga ggtgggcggg caggactcag gcacagaagg ctctgaatag 600 gccatggtgc tctttatatt aatctcgaga acagtgggaa ggagggatct ttaaatgggg 660 agcaacttgt ttggtttgtg tttttaaagc tctctggaga aggaattaca ggcagaaaag 720 ggtagggcca gtggctggag gggagacccc ccaagattta gaggccagca aggaggagag 780 gacaggccaa tagctaggag gaaatccagg agaggatgtg ttaccaaaac gaaaagagga 840 gcttcttcag gaggaggaag tggaccctct gctcagggca acggaactat caaggagggt 900 gagaagagac gtgtccctcc atccttagtt aaatgagtct ggggtgccaa gaattttcat 960 gcatgtttat taatctcaat aacaatcctg tttttttgcc ctcaaaatgt gttcaagata 1020 tttgtagatg tcatcttctt aatccttgta gtatcctgtt tgagtaagtg tcatcttgga 1080 agttaagtaa gttgtcaagg gtcagctcac taggaagtgg tgataccaga atatgaacca 1140 gtttcccgaa gcccagagcc tgaagccatg cgaaagccag cagggtgact cctccggctg 1200 caggcgagtg ggctgtgttt cacccggttt ctccttttct aggttacggc ctccgctgcc 1260 acagggccat catcaccatc tgccggctca ttggcatcaa agacatgtat gccaaggtct 1320 ctgggtccat taatatgctc agcctcaccc agggcctctt ccgtgggctc tccagacagg 1380 aaacccatca acagctggga ggacattcca ggcagaggga atcccaagtg cagtccttaa 1440 ggtgaggaag ccagcaggag gtggcgtgtc tctggccttg tgcagccagt tcctgtgctg 1500 ccctgcacct aggagagact cagcccctca cagcttggga tgttaccttg ccttttgttt 1560 gttttgaggg aagtttaatc tttaaactct ttggaaataa ataattatag ctttcatttg 1620 ttgagcacat gttatatgcc aatgtgatag aacctttaca tacatatctc agttcaagac 1680 tactttaaat attcatccaa agtaacaaaa gtaaatgaat tagggagacg gggttaataa 2740 DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

NOTE : Pour les tomes additionels, veuillez contacter 1e Bureau canadien des brevets JUMBO APPLICATIONS/PATENTS
THIS SECTION OF THE APPLICATION/PATENT CONTAINS MORE THAN ONE
VOLUME

NOTE: For additional volumes, please contact the Canadian Patent Office NOM DU FICHIER / FILE NAME
NOTE POUR LE TOME / VOLUME NOTE:

Claims (60)

What is claimed is:

1. An isolated polynucleotide selected from the group consisting of:
a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1- SEQ ID NO:1-184, b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ
ID NO:1- SEQ ID NO:1-184, c) a polynucleotide complementary to the polynucleotide of a), d) a polynucleotide complementary to the polynucleotide of b), and e) an RNA equivalent of a)-d).

2. An isolated polynucleotide of claim l, selected from the group consisting of SEQ ID NO:1-SEQ ID NO:1-184.

3. An isolated polynucleotide comprising at least 30 contiguous nucleotides of a polynucleotide of claim 1.

4. An isolated polynucleotide comprising at least 60 contiguous nucleotides of a polynucleotide of claim 1.

5. A composition for the detection of expression of secretory polynucleotides comprising at least one of the polynucleotides of claim 1 and a detectable label.

6. A method for detecting a target polynucleotide in a sample, said target polynucleotide having a sequence of a polynucleotide of claim 1, the method comprising:
a) amplifying said target polynucleotide or fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof.

7. A method for detecting a target polynucleotide in a sample, said target polynucleotide having a sequence of a polynucleotide of claim 1, the method comprising:
a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide or fragments thereof, and b) detecting the presence or absence of said hybridization complex, and, optionally, if present, the amount thereof.

8. A method of claim 7, wherein the probe comprises at least 30 contiguous nucleotides.

9. A method of claim 7, wherein the probe comprises at least 60 contiguous nucleotides.

10. A recombinant polynucleotide comprising a promoter sequence operably linked to a polynucleotide of claim 1.

11. A cell transformed with a recombinant polynucleotide of claim 10.

12. A transgenic organism comprising a recombinant polynucleotide of claim 10,

13. A method for producing a secretory polypeptide encoded by a polynucleotide of claim 1, the method comprising:
a) culturing a cell under conditions suitable for expression of the secretory polypeptide, wherein said cell is transformed with a recombinant polynucleotide comprising a promoter sequence operably linked to a polynucleotide of claim 1, and b) recovering the secretory polypeptide so expressed.

14. A method of claim 13, wherein the polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NO:185-369.

15. An isolated secretory polypeptide (SPTM) encoded by at least one of the polynucleotides of claim 2.

16. A method of screening for a test compound that specifically binds to the polypeptide of claim 15, the method comprising:
a) combining the polypeptide of claim 15 with at least one test compound under suitable conditions, and b) detecting binding of the polypeptide of claim 15 to the test compound, thereby identifying a compound that specifically binds to the polypeptide of claim 15.

17. A microarray wherein at least one element of the microarray is a polynucleotide of claim 3.

18. A method for generating a transcript image of a sample which contains polynucleotides, the method comprising:
a) labeling the polynucleotides of the sample, b contacting the elements of the microarray of claim 17 with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample.

19. A method for screening a compound for effectiveness in altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide sequence of a polynucleotide of claim 1, the method comprising:
a) exposing a sample comprising the target polynucleotide to a compound, under conditions suitable for the expression of the target polynucleotide, b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the compound and in the absence of the compound.

20. A method for assessing toxicity of a test compound, said method comprising:
a) treating a biological sample containing nucleic acids with the test compound, b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide of claim 1 under conditions whereby a specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence of a polynucleotide of claim 1 or fragment thereof, c) quantifying the amount of hybridization complex, and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound.

21. An array comprising different nucleotide molecules affixed in distinct physical locations on a solid substrate, wherein at least one of said nucleotide molecules comprises a first oligonucleotide or polynucleotide sequence specifically hybridizable with at least 30 contiguous nucleotides of a target polynucleotide, and wherein said target polynucleotide is a polynucleotide of claim 1.

22. An array of claim 21, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 30 contiguous nucleotides of said target polynucleotide.

23. An array of claim 21, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 60 contiguous nucleotides of said target polynucleotide

24. An array of claim 21, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to said target polynucleotide.

25. An array of claim 21, which is a microarray.

26. An array of claim 21, further comprising said target polynucleotide hybridized to a nucleotide molecule comprising said first oligonucleotide or polynucleotide sequence.

27. An array of claim 21, wherein a linker joins at least one of said nucleotide molecules to said solid substrate.

28. An array of claim 21, wherein each distinct physical location on the substrate contains multiple nucleotide molecules, and the multiple nucleotide molecules at any single distinct physical location have the same sequence, and each distinct physical location on the substrate contains nucleotide molecules having a sequence which differs from the sequence of nucleotide molecules at another distinct physical location on the substrate.

29. An isolated polypeptide selected from the group consisting of:
a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:185-369, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90%
identical to an amino acid sequence selected from the group consisting of SEQ
ID
NO:185-369, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369, and d) an immunogenic fragment of a. polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369.

30. An isolated polypeptide of claim 29, having a sequence selected from the group consisting of SEQ ID NO:185-369.

31. An isolated polynucleotide encoding a polypeptide of claim 29.

32. An isolated polynucleotide encoding a polypeptide of claim 30.

33. An isolated polynucleotide of claim 32, having a sequence selected from the group consisting of SEQ ID NO:1- SEQ ID NO:1-184.

34. Amisolated antibody which specifically binds to a secretory polypeptide of claim 29.

35. A diagnostic test for a condition or disease associated with the expression of SPTM in a biological sample, the method comprising:
a) combining the biological sample with an antibody of claim 34, under conditions suitable for the antibody to bind the polypeptide and form an antibody:polypeptide complex, and b) detecting the complex, wherein the presence of the complex correlates with the presence of the polypeptide in the biological sample.

36. The antibody of claim 34, wherein the antibody is:
a) a chimeric antibody, b) a single chain antibody, c) a Fab fragment, d) a F(ab')2 fragment, or e) a humanized antibody.

37. A composition comprising an antibody of claim 34 and an acceptable excipient.

38. A method of diagnosing a condition or disease associated with the expression of SPTM in a subject, comprising administering to said subject an effective amount of the composition of claim 37.

39. A composition of claim 37, wherein the antibody is labeled.

40. A method of diagnosing a condition or disease associated with the expression of SPTM in a subject, comprising administering to said subject an effective amount of the composition of claim 39.

41. A method of preparing a polyclonal antibody with the specificity of the antibody of claim 34, the method comprising:
a) immunizing an animal with a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369, or an immunogenic fragment thereof, under conditions to elicit an antibody response, b) isolating antibodies from said animal, and c) screening the isolated antibodies with the polypeptide, thereby identifying a polyclonal antibody which binds specifically to a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369.

42. An antibody produced by a method of claim 41.

43. A composition comprising the antibody of claim 42 and a suitable carrier.

44. A method of making a monoclonal antibody with the specificity of the antibody of claim 34, the method comprising:

a) immunizing an animal with a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369, or an immunogenic fragment thereof, under conditions to elicit an antibody response, b) isolating antibody producing cells from the animal, c) fusing the antibody producing cells with immortalized cells to form monoclonal antibody-producing hybridoma cells, d) culturing the hybridoma cells, and e) isolating from the culture monoclonal antibody which binds specifically to a polypeptide having an amino acid sequence selected from the group consisting of SEQ
ID NO:185-369.

45. A monoclonal antibody produced by a method of claim 44.

46. A composition comprising the antibody of claim 45 and a suitable carrier.

47. The antibody of claim 34, wherein the antibody is produced by screening a Fab expression library.

48. The antibody of claim 34, wherein the antibody is produced by screening a recombinant immunoglobulin library.

49. A method of detecting a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO185-369 in a sample, the method comprising:
a) incubating the antibody of claim 34 with a sample under conditions to allow specific binding of the antibody and the polypeptide, and b) detecting specific binding, wherein specific binding indicates the presence of a polypeptide having an amino acid sequence selected from the group consisting of SEQ
ID NO:185-369 in the sample.

50. A method of purifying a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369 from a sample, the method comprising:
a) incubating the antibody of claim 34 with a sample under conditions to allow specific binding of the antibody and the polypeptide, and b) separating the antibody from the sample and obtaining the purified polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:185-369.

51. A composition comprising a polypeptide of claim 29 and a pharmaceutically acceptable excipient.

52. A composition of claim 51, wherein the polypeptide has an amino acid sequence of SEQ
ID NO:185-369.

53. A method for treating a disease or condition associated with decreased expression of functional SPTM, comprising administering to a patient in need of such treatment the composition of claim 51.

54. A method for screening a compound for effectiveness as an agonist of a polypeptide of claim 29, the method comprising:
a) exposing a sample comprising a polypeptide of claim 29 to a compound, and b) detecting agonist activity in the sample.

55. A composition comprising an agonist compound identified by a method of claim 54 and a pharmaceutically acceptable excipient.

56. A method for treating a disease or condition associated with decreased expression of functional SPTM, comprising administering to a patient in need of such treatment a composition of claim 55.

57. A method for screening a compound for effectiveness as an antagonist of a polypeptide of claim 29, the method comprising:
a) exposing a sample comprising a polypeptide of claim 29 to a compound, and b) detecting antagonist activity in the sample.

58. A composition comprising an antagonist compound identified by a method of claim 57 and a pharmaceutically acceptable excipient.

59. A method for treating a disease or condition associated with overexpression of functional SPTM, comprising administering to a patient in need of such treatment a composition of claim 58.

60. A method of screening for a compound that modulates the activity of the polypeptide of claim 29, said method comprising:
a) combining the polypeptide of claim 29 with at least one test compound under conditions permissive for the activity of the polypeptide of claim 29, b) assessing the activity of the polypeptide of claim 29 in the presence of the test compound, and c) comparing the activity of the polypeptide of claim 29 in the presence of the test compound with the activity of the polypeptide of claim 29 in the absence of the test compound, wherein a change in the activity of the polypeptide of claim 29 in the presence of the test compound is indicative of a compound that modulates the activity of the polypeptide of claim 29.