CA2418496A1 - Secretory polypeptides and corresponding polynucleotides - Google Patents

Abstract

The present invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM
antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.

Description

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SECRETORY MOLECULES
TECHNICAL FIELD
The present invention relates to secretory molecules and to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, cell signaling and the expression of secretory molecules.
BACKGROUND OF THE INVENTION
Protein transport and secretion are essential for cellular function. Protein transport is mediated i o by a signal peptide located at the amino terminus of the protein to be transported or secreted. The signal peptide is comprised of about ten to twenty hydrophobic amino acids which target the nascent protein from the ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Proteins targeted to the ER may either proceed through the secretory pathway or remain in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that ~ transit through the secretory pathway are either secreted into the extracellular space or retained in the plasma membrane. Proteins that are retained in the plasma membrane contain one or more transmembrane domains, each comprised of about 20 hydrophobic amino acid residues. Proteins that are secreted from the cell are generally synthesized as inactive precursors that are activated by post-translational processing events during transit through the secretory pathway.
Such events include 2 o glycosylation, proteolysis, and removal of the signal peptide by a signal peptidase. Other events that may occur during protein transport include chaperone-dependent unfolding and folding of the nascent protein and interaction of the protein with a receptor or pore complex.
Examples of secretory proteins with amino terminal signal peptides are discussed below and include proteins with important roles in cell-to-cell signaling. Such proteins include transmembrane receptors and cell surface markers, 2 s extracellular matrix molecules, cytokines, hormones, growth and differentiation factors, neuropeptides, vasomediators, ion channels, transporters/pumps, and proteases. (Reviewed in Alberts, B. et al. (1994) Molecular Bioloey of The Cell, Garland Publishing, New York NY, pp. 557-560, 582-592.) G-protein coupled receptors (GPCRs) comprise a superfamily of integral membrane proteins which transduce extracellular signals. Not all GPCRs contain N-terminal signal peptides. GPCRs 3 o include receptors for biogenic amines such as dopamine, epinephrine, histamine, glutamate (metabotropic-type), acetylcholine (muscarinic-type), and serotonin; for lipid mediators of inflammation such as prostaglandins, platelet activating factor, and leukotrienes; for peptide hormones such as calcitonin, C5a anaphylatoxin, follicle stimulating hormone, gonadotropin releasing hormone, neurokinin, oxytocin, and thrombin; and for sensory signal mediators such as retinal photopigments and 3 5 olfactory stimulatory molecules. The structure of these highly conserved receptors consists of seven hydrophobic transmembrane regions, cysteine disulfide bridges between the second and third extracellular loops, an extracellular N-terminus, and a cytoplasmic C-terminus. The N-terminus interacts with ligands, the disulfide bridges interact with agonists and antagonists, and the large third intracellular loop interacts with G proteins to activate second messengers such as cyclic AMP, s phospholipase C, inositol triphosphate, or ion channels. (Reviewed in Watson, S. and Arkinstall, S.
(1994) The G-protein Linked Receptor Facts Book, Academic Press, San Diego CA, pp. 2-6; and Bolander, F.F. (1994) Molecular Endocrinolo~y, Academic Press, San Diego CA, pp. 162-176.) Other types of receptors include cell surface antigens identified on leukocytic cells of the immune system. These antigens have been identified using systematic, monoclonal antibody (mAb)-1 o based "shot gun" techniques. These techniques have resulted in the production of hundreds of mAbs directed against unknown cell surface leukocyte antigens. These antigens have been grouped into "clusters of differentiation" based on common immunocytochemical localization patterns in various differentiated and undifferentiated leukocytic cell types. Antigens in a given cluster are presumed to~
identify a single cell surface protein and are assigned a "cluster of differentiation" or "CD"
1 s designation. Some of the genes encoding proteins identified by CD antigens have been cloned and verified by standard molecular biology techniques. CD antigens have been characterized as both transmembrane proteins and cell surface proteins anchored to the plasma membrane via covalent attachment to fatty acid-containing glycolipids such as glycosylphosphatdylinositol (GPI). (Reviewed in Barclay, A.N. et al. (1995) The Leueocyte Ant yen Facts Book, Academic Press, San Diego CApp:
20 17-20.) Matrix proteins (MPs) are transmembrane and extracellular proteins which functon in formation, growth, remodeling, and maintenance of Issues and as important mediators and regulators of the inflammatory response. The expression and balance of MPs may be perturbed by biochemical changes that result from congenital, epigenetc, or infectous diseases. In additon, MPs affect 2 s leukocyte migraton, proliferaton, differentaton, and actvaton in the immune response. MPs are frequently characterized by the presence of one or more domains which may include collagen-like domains, EGF-like domains, immunoglobulin-like domains, and fibronectn like domains. In additon, MPs may be heavily glycosylated and may contain an Arginine-Glycine-Aspartate (RGD) tripeptde motf which may play a role in adhesive interactons. MPs include extracellular proteins such as 3 o fibronectn, collagen, galectn, vitronectn and its proteolytic derivative somatomedin B; and cell adhesion receptors such as cell adhesion molecules (CAMs), cadherins, and integrins. (Reviewed in Ayad, S. et al. (1994) The Extracellular Matrix Facts Book, Academic Press, San Diego CA, pp. 2-16;
Ruoslaht, E. (1997) Kidney Int. 51:1413-1417; Sjaastad, M.D. and Nelson, W.J.
(1997) BioEssays 19:47-55.) 3 s Cytokines are secreted by hematopoietc cells in response to injury or infection. Interleukins, neurotrophins, growth factors, interferons, and chemokines all define cytokine families that work in conjunction with cellular receptors to regulate cell proliferation and differentiation. In addition, cytokines effect activities such as leukocyte migration and function, hematopoietic cell proliferation, temperature regulation, acute response to infection, tissue remodeling, and apoptosis.
Chemokines, in particular, are small chemoattractant cytokines involved in inflammation, leukocyte proliferation and migration, angiogenesis and angiostasis, regulation of hematopoiesis, HIV
infectivity, and stimulation of cytokine secretion. Chemokines generally contain 70-100 amino acids and are subdivided into four subfamilies based on the presence of conserved cysteine-based motifs.
(Canard, R. and Gearing, A. (1994) The Cvtokine Facts Book, Academic Press, New York NY, pp.
l0 181-190, 210-213, 223-227.) Growth and differentiation factors are secreted proteins which function in intercellular communication. Some factors require ongomerization or association with MPs for activity. Complex interactions among these factors and their receptors trigger intracellular signal transduction pathways that stimulate or inhibit cell division, cell differentiation, cell signaling, and cell motility. Most growth 1 s and differentiation factors act on cells in their local environment (paracrine signaling). There are three broad classes of growth and differentiation factors. The first class includes the large polypeptide growth factors such as epidermal growth factor, fibroblast growth factor, transforming growth factor, insulin-like growth factor, and platelet-derived growth factor. The second class includes the hematopoietic growth factors such as the colony stimulating factors (CSFs).
Hematopoietic growth 2 o factors stimulate the proliferation and differentiation of blood cells such as B-lymphocytes, T-lymphocytes, erythrocytes, platelets, eosinophils, basophils, neutrophils, macrophages, and their stem cell precursors. The third class includes small peptide factors such as bombesin, vasopressin, oxytocin, endothenn, transferrin, angiotensin II, vasoactive intestinal peptide, and bradykinin which function as hormones to regulate cellular functions other than proliferation.
2 s Growth and differentiation factors play critical roles in neoplastic transformation of cells in vitro and in tumor progression in vivo. Inappropriate expression of growth factors by tumor cells may contribute to vascularization and metastasis of tumors. During hematopoiesis, growth factor misregulation can result in anemias, leukemias, and lymphomas. Certain growth factors such as interferon are cytotoxic to tumor cells both in vivo and in vitro. Moreover, some growth factors and 3 o growth factor receptors are related both structurally and functionally to oncoproteins. In addition, growth factors affect transcriptional regulation of both proto-oncogenes and oncosuppressor genes.
(Reviewed in Pimentel, E. (1994) Handbook of Growth Factors, CRC Press, Ann Arbor MI, pp. 1-9.) Proteolytic enzymes or proteases either activate or deactivate proteins by hydrolyzing peptide bonds. Proteases are found in the cytosol, in membrane-bound compartments, and in the extracellular 3 5 space. The major famines are the zinc, serine, cysteine, thiol, and carboxyl proteases.

Ion channels, ion pumps, and transport proteins mediate the transport of molecules across cellular membranes. Transport can occur by a passive, concentration-dependent mechanism or can be linked to an energy source such as ATP hydrolysis. Symporters and antiporters transport ions and small molecules such as amino acids, glucose, and drugs. Symporters transport molecules and ions s unidirectionally, and antiporters transport molecules and ions bidirectionally. Transporter superfamilies include facilitative txansporters and active ATP-binding cassette transporters which are involved in multiple-drug resistance and the targeting of antigenic peptides to MHC Class I molecules.
These transporters bind to a specific ion or other molecule and undergo a conformational change in order to transfer the ion or molecule across the membrane. (Reviewed in Alberts, B. et al. (1994) s o Molecular Biolo~y of The Cell, Garland Publishing, New York NY, pp. 523-546.) Ion channels are formed by txansmembrane proteins which create a lined passageway across the membrane through which water and ions, such as Na+, K+, Ca2+, and Cl-, enter and exit the cell. For example, chloride channels are involved.in the regulation of the membrane electric potential as well as absorption and secretion of ions across the membrane. Chloride channels also regulate the internal pH
is of membrane-bound organelles.
Ion pumps are ATPases which actively maintain membrane gradients. Ion pumps are classified as P, V, or F according to their structure and function. All have one or more binding sites for ATP in their cytosolic domains. The P-class ion pumps include Ca2+ ATPase and Na+/K+
ATPase and function in transporting H+, Nat, Kt, and Ca2~ ions. P-class pumps consist of two a and two (3 transmembrane 2 o subunits. The V- and F-class ion pumps have similar structures but transport only H+. F class H~
pumps mediate transport across the membranes of mitochondria and chloroplasts, while V-class H+
pumps regulate acidity inside lysosomes, endosomes, and plant vacuoles.
A family of structurally related intrinsic membrane proteins known as facilitative glucose transporters catalyze the movement of glucose and other selected sugars across the plasma membrane.
2 5 The proteins in this family contain a highly conserved, large transmembrane domain comprised of 12 a-helices, and several weakly conserved, cytoplasmic and exoplasmic domains.
(Pessin, J.E. and Bell, G.I. (1992) Annu. Rev. Physiol, 54:911-930.) Amino acid transport is mediated by Nay dependent amino acid transporters.
These transporters are involved in gastrointestinal and renal uptake of dietary and cellular amino acids and in s o neuronal reuptake of neurotransmitters. Transport of cationic amino acids is mediated by the system y+ family and the cationic amino acid transporter (CAT) family. Members of the CAT family share a high degree of sequence homology, and each contains 12-14 putative transmembrane domains. (Ito, K.
and Groudine, M, (1997) J. Biol. Chem. 272:26780-26786.) Hormones are secreted molecules that travel through the circulation and bind to speciFic 3 s receptors on the surface of, or within, target cells. Although they have diverse biochemical compositions and mechanisms of action, hormones can be grouped into two categories. One category includes small lipophilic hormones that diffuse through the plasma membrane of target cells, bind to cytosolic or nuclear receptors, and form a complex that alters gene expression. Examples of these molecules include retinoic acid, thyroxine, and the cholesterol-derived steroid hormones such as progesterone, s estrogen, testosterone, cortisol, and aldosterone. The second category includes hydrophilic hormones that function by binding to cell surface receptors that transduce signals across the plasma membrane.
Examples of such hormones include amino acid derivatives such as catecholamines and peptide hormones such as glucagon, insulin, gastrin, secretin, cholecystokinin, adrenocorticotropic hormone, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, and vasopressin. (See, to for example, Lodish et al. (1995) Molecular Cell Biolo~y, Scientific American Books Inc., New York NY, pp. 856-864.) Neuropeptides and vasomediators (NP/VM) comprise a large family of endogenous signaling molecules. Included in this family are neuropeptides and neuropeptide hormones such as bombesin, neuropeptide Y, neurotensin, neuromedin N, melanocortins, opioids, galanin, somatostatin, tachykinins, s s urotensin IT and related peptides involved in smooth muscle stimulation, vasopressin, vasoactive intestinal peptide, and circulatory system-borne signaling molecules such as angiotensin, complement, calcitonin, endothelins, formyl-methionyl peptides, glucagon, cholecystokinin and gastrin. NP/VMs can transduce signals directly, modulate the activity or release of other neurotransmitters and hormones, and act as catalytic enzymes in cascades. The effects of NP/VMs range from extremely brief to long-2 0 lasting. (Reviewed in Martin, C.R. et al. (1985) Endocrine Physiolo~y, Oxford University Press, New York, NY, pp. 57-62.) The discovery of new secretory molecules satisfies a need in the art by providing new compositions which are useful in the diagnosis, study, prevention, and treatment of diseases associated with, as well as effects of exogenous compounds on, cell signaling and the expression of secretory 2 5 molecules.
SUMMARY OF THE INVENTION
The present invention relates to nucleic acid sequences comprising human polynucleotides encoding secretory polypeptides that contain signal peptides and/or txansmembrane domains. These 3 o human polynucleotides (sptm) as presented in the Sequence Listing uniquely identify partial or full length genes encoding structural, functional, and regulatory polypeptides involved in cell signaling.
The invention provides an isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-79; b) a naturally occurring polynucleotide sequence having at least 90% sequence 3 s identity to a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-79; c) a polynucleotide sequence complementary to a); d) a polynucleotide sequence complementary to b); and e) an RNA equivalent of a) through d). In one alternative, the polynucleotide comprises a polynucleotide sequence selected from the group consisting of SEQ ID NO:I-79.
In another alternative, the polynucleotide comprises at least 60 contiguous nucleotides of a polynucleotide sequence selected s from the group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID
NO:1-79; b) a naturally occurring polynucleotide sequence having at least 90%
sequence identity to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-79;
c) a polynucleotide sequence complementary to a); d) a polynucleotide sequence complementary to b); and e) an RNA
equivalent of a) through d). The invention further provides a composition for the detection of 1 o expression of secretory polynucleotides comprising at least one isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-79; b) a naturally occurring polynucleotide sequence having at least 90% sequence identity to a polynucleotide sequence selected from the group consisting of SEQ
. ID N0:1-79; c) a polynucleotide sequence complementary to a); d) a polynucleotide sequence 1 s complementary to b); and e) an RNA equivalent of a) through d); and a detectable label.
The invention also provides a method for detecting a target polynucleotide in a sample, said target polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID NO:l-79;
b) a naturally occurring polynucleotide sequence having at least 90% sequence identity to a polynucleotide sequence 2 o selected from the group consisting of SEQ ID N0:1-79; c) a polynucleotide sequence complementary to a); d) a polynucleotide sequence complementary to b); and e) an RNA equivalent of a) through d). The method comprises a) amplifying said target polynucleotide or a fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof.
2 s The invention also provides a method fox detecting a target polynucleotide in a sample, said target polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID NO:I-79;
b) a naturally occurring polynucleotide sequence having at least 90% sequence identity to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-79; c) a polynucleotide sequence complementary to 3 o a); d) a polynucleotide sequence cpmplementary to b); and e) an RNA
equivalent of a) through d). The method comprises a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide, and b) detecting the presence or absence of 3 s said hybridization complex, and, optionally, if present, the amount thereof. In one alternative, the probe comprises at least 30 contiguous nucleotides. In another alternative, the probe comprises at least 60 contiguous nucleotides.
The invention further provides a recombinant polynucleotide comprising a promoter sequence operably linked to an isolated polynucleotide comprising a polynucleotide sequence selected from the s group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID NO:1 79; b) a naturally occurring polynucleotide sequence having at least 90%
sequence identity to a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-79;
c) a polynucleotide sequence complementary to a); d) a polynucleotide sequence complementary to b); and e) an RNA
equivalent of a) through d). In one alternative, the invention provides a cell transformed with the 1 o recombinant polynucleotide. In another alternative, the invention provides a transgenic organism comprising the recombinant polynucleotide. In a further alternative, the invention provides a method for producing a secretory polypeptide, the method comprising a) culturing a cell under conditions suitable for expression of the secretory polypeptide, wherein said cell is transformed with the recombinant polynucleotide, and b) recovering the secretory ~polypeptide so expressed.
~. s The invention also provides a purified secretory polypeptide (SPTM) encoded by at least one polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID
NO:1-79. Additionally, the invention provides an isolated antibody which specifically binds to the secretory polypeptide. The invention further provides a method of identifying a test compound which specifically binds to the secretory polypeptide, the method comprising the steps of a) providing a test 2 o compound; b) combining the secretory polypeptide with the test compound for a sufficient time and under suitable conditions for binding; and e) detecting binding of the secretory polypeptide to the test compound, thereby identifying the test compound which specifically binds the secretory polypeptide.
The invention further provides a microarray wherein at least one element of the microarray is an isolated polynucleotide comprising at least 60 contiguous nucleotides of a polynucleotide comprising 2 s a polynucleotide sequence selected from the group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID NO:l-79; b) a naturally occurring polynucleotide sequence having at least 90% sequence identity to a polynucleotide sequence selected from the group consisting of SEQ
ID N0:1-79; c) a polynucleotide sequence complementary to a); d) a polynucleotide sequence complementary to b); and e) an RNA equivalent of a) through d). The invention also provides a method 3 o for generating a transcript image of a sample which contains polynucleotides. The method comprises a) labeling the polynucleotides of the sample, b) contacting the elements of the microarray with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample.
Additionally, the invention provides a method for screening a compound for effectiveness in 3 s altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide sequence selected from the group consisting of a) a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-79; b) a naturally occurring polynucleotide sequence having at least 90% sequence identity to a polynucleotide sequence selected from the group consisting of SEQ
ID NO:1-79; c) a polynucleotide sequence complementary to a); d) a polynucleotide sequence s complementary to b); and e) an RNA equivalent of a) through d). 'The method comprises a) exposing a sample comprising the target polynucleotide to a compound, and b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the compound and in the absence of the compound.
The invention further provides a method for assessing toxicity of a test compound, said method s o comprising a) treating a biological sample containing nucleic acids with the test compound; b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide comprising a polynucleotide sequence selected from the group consisting of i) a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-79; ii) a naturally occurring polynucleotide sequence having at least 90%
sequence identity to a 15 polynucleotide sequence selected from the group consisting of SEQ ID NO:1-79; iii) a polynucleotide sequence complementary to i), iv) a polynucleotide sequence complementary to ii), and v) an RNA
equivalent of i)-iv). Hybridization occurs under conditions whereby a specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence selected from the group consisting of i) a 2 o polynucleotide sequence selected from the group consisting of SEQ ID N0:1-79; ii) a naturally occurring polynucleotide sequence having at least 90% sequence identity to a polynucleotide sequence selected from the group consisting of SEQ ID N0:1-79; iii) a polynucleotide sequence complementary to i), iv) a polynucleotide sequence complementary to ii), and v) an RNA equivalent of i)-iv), and alternatively, the target polynucleotide comprises a fragment of a polynucleotide sequence 2 5 selected from the group consisting of i-v above; c) quantifying the amount of hybridization complex;
and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound.
DESCRIPTION OF THE TABLES
3 o Table 1 shows the sequence identification numbers (SEQ ID NOa) and template identification numbers (template IDs) corresponding to the polynucleotides of the present invention, along with polynucleotide segments of each template sequence as defined by the indicated "start" and "stop"
nucleotide positions. The reading frames of the polynucleotide segments are shown, and the polypeptides encoded by the polynucleotide segments constitute either signal peptide (SP) or 3 5 transmembrane (T1VI) domains, as indicated. The membrane topology of the encoded polypeptide sequence is indicated, the N-terminus (N) listed as being oriented to either the cytosolic (in) or non-cytosolic (out) side of the cell membrane or organelle.
Table 2 shows the sequence identification numbers (SEQ ID NOa) corresponding to the polynucleotides of the present invention, along with component sequence identification numbers s (component IDs) corresponding to each template. The component sequences, wluch were used to assemble the template sequences, are defined by the indicated "start" and "stop" nucleotide positions along each template.
Table 3 shows the tissue distribution profiles for the templates of the invention.
Table 4 summarizes the bioinformatics tools which are useful for analysis of the 1 o polynucleotides of the present invention. The first column of Table 4 lists analytical tools, programs, and algorithms, the second column provides brief descriptions thereof, the third column presents appropriate references, all of which are incorporated by reference herein in their entirety, and the fourth column presents, where applicable, the scores, probability values, and other parameters used to evaluate the strength of a match between two sequences (the higher the score, the greater the homology between 15 two seduences).
DETAILED DESCRIPTION OF THE INVENTION
Before the nucleic acid sequences and methods are presented, it is to be understood that this invention is not limited to the particular machines, methods, and materials described. Although 2 o particular embodiments are described, machines, methods, and materials similar or equivalent to these embodiments may be used to practice the invention. The preferred machines, methods, and materials set forth are not intended to limit the scope of the invention which is limited only by the appended claims.
The singular forms "a", "an", and "the" include plural reference unless the context clearly 2 5 dictates otherwise. All technical and scientific terms have the meanings commonly understood by one of ordinary skill in the art. All publications are incorporated by reference for the purpose of describing and disclosing the cell Lines, vectors, and methodologies which are presented and which might be used in connection with the invention. Nothing in the specification is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention.
Definitions As used herein, the lower case "sptm" refers to a nucleic acid sequence, while the upper case "SPTM" refers to an amino acid sequence encoded by sptm. A "full-length" sptm refers to a nucleic acid sequence containing the entire coding region of a gene endogenously expressed in human tissue.
3 5 "Adjuvants" are materials such as Freund's adjuvant, mineral gels (aluminum hydroxide), and surface active substances (lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, and dinitrophenol) which may be administered to increase a host's immunological response.
"Allele" refers to an alternative form of a nucleic acid sequence, Alleles result from a s "mutation," a change or an alternative reading of the genetic code. Any given gene may have none, one, or many allelic forms. Mutations which give rise to alleles include deletions, additions, or substitutions of nucleotides. Each of these changes may occur alone, or in combination with the others, one or more times in a given nucleic acid sequence. The present invention encompasses allelic sptm.
"Amino acid sequence" refers to a peptide, a polypeptide, or a protein of either natural or 1 o synthetic origin. The amino acid sequence is not limited to the complete, endogenous amino acid sequence and may be a fragment, epitope, variant, or derivative of a protein expressed by a nucleic acid sequence.
"Amplification" refers to the production of additional copies of a sequence and is carried out using polymerase chain reaction (PCR) technologies well known in the art.
15 "Antibody" refers to intact molecules as well as to fragments thereof, such as Fab, F(ab')2, and Fv fragments, which are capable of binding the epitopic determinant.
Antibodies that bind SPTM
polypeptides can be prepared using intact polypeptides or using fragments containing small peptides of interest as the immunizing antigen. The polypeptide or peptide used to immunize an animal (e.g., a mouse, a rat, or a rabbit) can be derived from the translation of RNA, or synthesized chemically, and 2 o can be conjugated to a carrier protein if desired. Commonly used carriers that are chemically coupled to peptides include bovine serum albumin, thyroglobulin, and keyhole limpet hemocyanin (KLH). The coupled peptide is then used to immunize the animal.
"Antisense sequence" refers to a sequence capable of specifically hybridizing to a target sequence. The antisense sequence may include DNA, RNA, or any nucleic acid mimic or analog such 2 s as peptide nucleic acid (PNA); oligonucleotides having modified backbone linkages such as phosphorothioates, methylphosphonates, or benzylphosphonates; oligonucleotides having modified sugar groups such as 2'-methoxyethyl sugars or 2'-methoxyethoxy sugars; or oligonucleotides having modified bases such as 5-methyl cytosine, 2'-deoxyuracil, or 7-deaza-2'-deoxyguanosine.
"Antisense sequence" refers to a sequence capable of specifically hybridizing to a target 3 o sequence. The antisense sequence can be DNA, RNA, or any nucleic acid mimic or analog.
"Antisense technology" refers to any technology which relies on the specific hybridization of an antisense sequence to a taxget sequence.
A "bin" is a portion of computer memory space used by a computer program for storage of data, and bounded in such a manner that data stored in a bin may be retrieved by the program.
3 5 "Biologically active" refers to an amino acid sequence having a structural, regulatory, or biochemical function of a naturally occurring amino acid sequence.
"Clone joining" is a process for combining gene bins based upon the bins' containing sequence information from the same clone. The sequences may assemble into a primary gene transcript as well as one or more splice variants.
s "Complementary" describes the relationship between two single-stranded nucleic acid sequences that anneal by base-pairing (5'-A-G-T-3' pairs with its complement 3'-T-GA-5').
A "component sequence" is a nucleic acid sequence selected by a computer program such as PHRED and used to assemble a consensus or template sequence from one or more component sequences.
~ o A "consensus sequence" or "template sequence" is a nucleic acid sequence which has been assembled from overlapping sequences, using a computer program for fragment assembly such as the GELVIEW fragment assembly system (Genetics Computer Group (GCG), Madison WI) or using a relational database management system (RDMS).
"Conservative amino acid substitutions" are those substitutions that, when made, least interfere s s with the properties of the original protein, i. e., the structure and especially the function of the protein is conserved and not significantly changed by such substitutions. The table below shows amino acids which may be substituted for an original amino acid in a protein and which are regarded as conservative substitutions.
2 o Original Residue Conservative Substitution Ala Gly, Ser Arg His, Lys Asn Asp, Gln, His Asp Asn, Glu Cys Ala, Ser Gln Asn, Glu, His Glu Asp, Gln, His Gly Ala His Asn, Arg, Gln, Glu 3 o Ile Leu, Val Leu Ile, Val Lys Arg, Gln, Glu Met Leu, Ile Phe His, Met, Leu, Trp, Tyr 3 5 Ser Cys, Thr Thr Ser, Val Trp Phe, Tyr Tyr His, Phe, Trp Val Ile, Leu, Thr Conservative substitutions generally maintain (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a beta sheet or alpha helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain.
"Deletion" refers to a change in either a nucleic or amino acid sequence in which at Ieast one nucleotide or amino acid residue, respectively, is absent.
"Derivative" refers to the chemical modification of a nucleic acid sequence, such as by replacement of hydrogen by an alkyl, acyl, amino, hydroxyl, or other group.
The terms "element" and "array element" refer to a polynucleotide, polypeptide, or other chemical compound having a unique and defined position on a microaxray.
"E-value" refers to the statistical probability that a match between two sequences occurred by chance.
A "fragment" is a unique portion of sptm or SPTM which is identical in sequence to but shorter in length than the parent sequence. A fragment may comprise up to the entire length of the defined sequence, minus one nucleotide/amino acid residue. For example, a fragment may comprise from 10 to 1000 contiguous amino acid residues or nucleotides. A fragment used as a probe, pximer, antigen, therapeutic molecule, or for other purposes, may be at least S, 10, 1S, 16, 20, 2S, 30, 40, 50, 60, 75, 100, 150, 2S0 or at least S00 contiguous amino acid residues ox nucleotides in length. Fragments may be preferentially selected from certain regions of a molecule. For example, a polypeptide fragment may comprise a certain length of contiguous amino acids selected from the first 2S0 or S00 amino acids (or 2 o first 25 % or SO%) of a polypeptide as shown in a certain defined sequence. Clearly these lengths are exemplary, and any length that is supported by the specification, including the Sequence Listing and the figures, may be encompassed by the present embodiments.
A fragment of sptm comprises a region of unique polynucleotide sequence that specifically identifies sptm, fox example, as distinct from any other sequence in the same genome. A fragment of 2 s sptm is useful, for example, in hybridization and amplif canon technologies and in analogous methods that distinguish sptm from related polynucleotide sequences. The precise length of a fragment of sptm and the region of sptm to which the fragment corresponds are routinely determinable by one of ordinary skill in the art based on the intended purpose for the fragment.
A fragment of SPTM is encoded by a fragment of sptm. A fragment of SPTM
comprises a 3 o region of unique amino acid sequence that specifically identifies SPTM.
For example, a fragment of SPTM is useful as an immunogenic peptide for the development of antibodies that specifically recognize SPTM. The precise length of a fragment of SPTM and the region of SPTM to which the fragment corresponds are routinely determinable by one of ordinary skill in the art based on the intended purpose for the fragment.

A "full length" nucleotide sequence is one containing at least a start site for translation to a protein sequence, followed by an open reading frame and a stop site, and encoding a "full length"
polypeptide.
"Hit" refers to a sequence whose annotation will be used to describe a given template. Criteria s for selecting the top hit are as follows: if the template has one or more exact nucleic acid matches, the top hit is the exact match with highest percent identity. If the template has no exact matches but has significant protein hits, the top hit is the protein hit with the lowest E-value. If the template has no significant protein hits, but does have significant non-exact nucleotide hits, the top hit is the nucleotide hit with the lowest E-value.
"Homology" refers to sequence similarity either between a reference nucleic acid sequence and at least a fragment of an sptm or between a reference amino acid sequence and a fragment of an SPTM.
"Hybridization" refers to the process by which a strand of nucleotides anneals with a complementary strand through base pairing. Specific hybridization is an indication that two nucleic acid sequences share a high degree of identity. Specific hybridization complexes form under defined annealing conditions, and remain hybridized after the "washing" step. The defined hybridization conditions include the annealing conditions and the washing step(s), the latter of which is particularly important in determining the stringency of the hybridization process, with more stringent conditions allowing less non-specific binding, i.e., binding between pairs of nucleic acid probes that are not perfectly matched. Permissive conditions for annealing of nucleic acid sequences are routinely 2 o determinable and may be consistent among hybridization experiments, whereas wash conditions may be varied among experiments to achieve the desired stringency.
Generally, stringency of hybridization is expressed with reference to the temperature under which the wash step is carried out. Generally, such wash temperatures are selected to be about 5°C to 20°C lower than the thermal melting point (T,~ for the specific sequence at a defined ionic strength and 2 s pH. The Tm is the temperature (under defined ionic strength and pH) at which 50% of the target sequence hybridizes to a perfectly matched probe. An equation for calculating Tm and conditions for nucleic acid hybridization is well known and can be found in Sambrook et al., 1989, Molecular Cloning: A Laboratory Manual, 2nd ed., vol. 1-3, Cold Spring Harbor Press, Plainview NY; specifically see volume 2, chapter 9.
3 o High stringency conditions for hybridization between polynucleotides of the present invention include wash conditions of 68°C in the presence of about 0.2 x SSC and about 0.1 % SDS, for 1 hour.
Alternatively, temperatures of about 65°C, 60°C, or 55°C
may be used. SSC concentration may be varied from about 0.2 to 2 x SSC, with SDS being present at about 0.1 %.
Typically, blocking reagents are used to block non-specific hybridization. Such blocking reagents include, for instance, denatured 3 s salmon sperm DNA at about 100-200 ~ g/znl. Useful variations on these conditions will be readily apparent to those skilled in the art. Hybridization, particularly under high stringency conditions, may be suggestive of evolutionary similarity between the nucleotides. Such similarity is strongly indicative of a similar role for the nucleotides and their resultant proteins.
Other parameters, such as temperature, salt concentration, and detergent concentration may be s varied to achieve the desired stringency. Denaturants, such as formamide at a concentration of about 35-50% vlv, may also be used under particular circumstances, such as RNA:DNA
hybridizations.
Appropriate hybridization conditions are routinely determinable by one of ordinary skill in the art.
"Immunogenic" describes the potential for a natural, recombinant, or synthetic peptide, epitope, polypeptide, or protein to induce antibody production in appropriate animals, cells, or cell lines.
"Insertion" or "addition" refers to a change in either a nucleic or amino acid sequence in which at least one nucleotide or residue, respectively, is added to the sequence.
"Labeling" refers to the covalent or noncovalent joining of a polynucleotide, polypeptide, or antibody with a reporter molecule capable of producing a detectable or measurable signal.
"Microarray" is any arrangement of nucleic acids, amino acids, antibodies, etc., on a substrate.
~ s The substrate may be a solid support such as beads, glass, paper, nitrocellulose, nylon, or an appropriate membrane.
"Linkers" are short stretches of nucleotide sequence which may be added to a vector or an sptm to create restriction endonuclease sites to facilitate cloning. "Polylinkers"
are engineered to incorporate multiple restriction enzyme sites and to provide for the use of enzymes which leave 5' or 3' overhangs (e.g., BamHI, EcoRI, and HindIII) and those which provide blunt ends (e.g., EcoRV, SnaBI, and StuI).
"Naturally occurring" refers to an endogenous polynucleotide or polypeptide that may be isolated from viruses or prokaryotic or eukaryotic cells.
"Nucleic acid sequence" refers to the specific order of nucleotides joined by phosphodiester bonds in a linear, polymeric arrangement. Depending on the number of nucleotides, the nucleic acid sequence can be considered an oligomer, oligonucleotide, or polynucleotide.
The nucleic acid can be DNA, RNA, or any nucleic acid analog, such as PNA, may be of genomic or synthetic origin, may be either double-stranded or single-stranded, and can represent either the sense or antisense (complementary) strand.
"Oligomer" refers to a nucleic acid sequence of at least about 6 nucleotides and as many as 3 o about 60 nucleotides, preferably about 15 to 40 nucleotides, and most preferably between about 20 and nucleotides, that may be used in hybridization or amplification technologies.
Oligomers may be used as, e.g., primers for PCR, and are usually chemically synthesized.
"Operably linked" refers to the situation in which a first nucleic acid sequence is placed in a functional relationship with the second nucleic acid sequence. For instance, a promoter is operably 3 5 linked to a coding sequence if the promoter affects the transcription or expression of the coding sequence. Generally, operably linked DNA sequences may be in close proximity or contiguous and, where necessary to join two protein coding regions, in the same reading frame.
"Peptide nucleic acid" (PNA) refers to a DNA mimic in which nucleotide bases are attached to a pseudopeptide backbone to increase stability. PNAs, also designated antigene agents, can prevent gene expression by targeting complementary messenger RNA.
The phrases "percent identity" and "% identity", as applied to polynucleotide sequences, refer to the percentage of residue matches between at least two polynucleotide sequences aligned using a standardized algorithm. Such an algorithm may insert, in a standardized and reproducible way, gaps in the sequences being compared in order to optimize alignment between two sequences, and therefore 1 o achieve a more meaningful comparison of the two sequences.
Percent identity between polynucleotide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEGALIGN
version 3.12e sequence alignment program. This program is part of the LASERGENE software package, a suite of molecular biological analysis programs (DNASTAR, Madison WI). CLUSTAL V is described in Higgins, D. G.
and Sharp, P.M. (1989) CABIOS 5:151-153 and in Higgins, D.G. et al. (1992) CABIOS 8:189-191.
For pairwise alignments of polynucleotide sequences, the default parameters are set as follows:
Ktuple=2, gap penalty=5, window=4, and "diagonals saved"=4. The "weighted"
residue weight table is selected as the default. Percent identity is reported by CLUSTAL V as the "percent similarity" between aligned polynucleotide sequence pairs.
2 o Alternatively, a suite of commonly used and freely available sequence comparison algorithms is provided by the National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST) (Altschul, S.F. et al. (1990) J. Mol. Biol. 215:403-410), which is available from several sources, including the NCBI, Bethesda, MD, and on the Internet at http://www.ncbi.nlm.nih.gov/BLAST/. The BLAST software suite includes vaxious sequence analysis 2 5 programs including "blastn," that is used to determine alignment between a known polynucleotide sequence and other sequences on a variety of databases. Also available is a tool called "BLAST 2 Sequences" that is used for direct pairwise comparison of two nucleotide sequences. "BLAST 2 Sequences" can be accessed and used interactively at http:/lwww.ncbi.nlm.nih.gov/gorf/b12/. The "BLAST 2 Sequences" tool can be used for both blastn and blastp (discussed below). BLAST
3 o programs are commonly used with gap and other parameters set to default settings. For example, to compare two nucleotide sequences, one may use blastn with the "BLAST 2 Sequences" tool Version 2Ø9 (May-07-1999) set at default parameters. Such default parameters may be, for example:
Matrix: BLOSUM62 Reward for rytatch: 1 35 Peftalty for ntisntatcla: -2 Opera Gap: 5 and Extension Gap: 2 penalties Gap x drop-off. 50 Expect: 10 Word Size: 1l s Filter: on Percent identity may be measured over the length of an entire defined sequence, for example, as defined by a particular SEQ ID number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined sequence, for instance, a fragment of at least 20, at least 30, at least 40, at least 50, at least 70, at least 100, or at least 200 contiguous nucleotides. Such lengths are exemplary only, and it is understood that any fragment length supported by the sequences shown herein, in figures or Sequence Listings, may be used to describe a length over which percentage identity may be measured.
Nucleic acid sequences that do not show a high degree of identity may nevertheless encode similar amino acid sequences due to the degeneracy of the genetic code. It is understood that changes in nucleic acid sequence can be made using this degeneracy to produce multiple nucleic acid sequences that all encode substantially the same protein.
The phrases "percent identity" and "% identity", as applied to polypeptide sequences, refer to the percentage of residue matches between at least two polypeptide sequences aligned using a standardized algorithm. Methods of polypeptide sequence alignment are well-known. Some alignment 2 o methods take into account conservative amino acid substitutions. Such conservative substitutions, explained in more detail above, generally preserve the hydrophobicity and acidity of the substituted residue, thus preserving the structure (and therefore function) of the folded polypeptide.
Percent identity between polypeptide sequences may be determined using the default parameters of the CLUSTAL V algorithm as incorporated into the MEGALIGN version 3.12e sequence alignment 2 5 program (described and referenced above). For pairwise alignments of polypeptide sequences using CLUSTAL V, the default parameters are set as follows: Ktuple=1, gap penalty=3, window=5, and "diagonals saved"=5. The PAM250 matrix is selected as the default residue weight table. As with polynucleotide alignments, the percent identity is reported by CLUSTAL V as the "percent similarity"
between aligned polypeptide sequence pairs.
3 o Alternatively the NCBI BLAST software suite may be used. For example, for a pairwise comparison of two polypeptide sequences, one may use the "BLAST 2 Sequences"
tool Version 2Ø9 (May-07-1999) with blastp set at default parameters. Such default parameters may be, for example:
Matrix: BLOSUM62 Open Gap: 11 and Extension Gap: 1 penalty 3 5 Gap x drop-off.- 50 Expect: 10 Word Size: 3 Filter-: on Percent identity may be measured over the length of an entire defined polypeptide sequence, for s example, as defined by a particular SEQ ID number, or may be measured over a shorter length, for example, over the length of a fragment taken from a larger, defined polypeptide sequence, for instance, a fragment of at least 15, at least 20, at least 30, at least 40, at least 50, at least 70 or at least 150 contiguous residues. Such lengths are exemplary only, and it is understood that any fragment length supported by the sequences shown herein, in figures ar Sequence Listings, may be used to describe a length over which percentage identity may be measured.
"Post-translational modification" of an SPTM may involve lipidation, glycosylation, phosphorylation, acetylation, racemization, proteolytic cleavage, and other modifications known in the art. These processes may occur synthetically or biochemically. Biochemical modifications will vary by cell type depending on the enzymatic milieu and the SPTM.
"Probe" refers to sptm or fragments thereof, which are used to detect identical, allelic or related nucleic acid sequences. Probes are isolated oligonucleotides or polynucleotides attached to a detectable label or reporter molecule. Typical labels include radioactive isotopes, ligands, chemiluminescent agents, and enzymes. "Primers" are short nucleic acids, usually DNA
oligonucleotides, which may be annealed to a target polynucleotide by complementary base-pawing. The primer may then be extended 2 o along the target DNA strand by a DNA polymerase enzyme. Primer pairs can be used for amplification (and identification) of a nucleic acid sequence, e.g., by the polymerase chain reaction (PCR).
Probes and primers as used in the present invention typically comprise at least 15 contiguous nucleotides of a known sequence. In order to enhance specificity, longer probes and primers may also be employed, such as probes and primers that comprise at least 20, 30, 40, 50, 60, 70, 80, 90, 100, or 2 s at least 150 consecutive nucleotides of the disclosed nucleic acid sequences. Probes and primers may be considerably longer than these examples, and it is understood that any length supported by the specification, including the figures and Sequence Listing, may be used.
Methods for preparing and using probes and primers are described in the references, for example Sambrook et al., 1989, Molecular Cloning: A Laborator~Manual, 2°d ed., vol. 1-3, Cold 3 o Spring Harbor Press, Plainview NY; Ausubel et a1.,1987, Current Protocols in Molecular Biolo~y, Greene Publ. Assoc. & Wiley-Intersciences, New York NY; Innis et al., 1990, PCR Protocols, A Guide to Methods and Applications, Academic Press, San Diego CA. PCR primer pairs can be derived from a known sequence, for example, by using computer programs intended for that purpose such as Primer (Version 0.5, 1991, Whitehead Institute for Biomedical Research, Cambridge MA).

Oligonucleotides for use as primers are selected using software known in the art for such purpose. For example, OLIGO 4.06 software is useful for the selection of PCR
primer pairs of up to 100 nucleotides each, and for the analysis of oligonucleotides and larger polynucleotides of up to 5,000 nucleotides from an input polynucleotide sequence of up to 32 kilobases.
Similar primer selection s programs have incorporated additional features for expanded capabilities.
For example, the PrimOU
primer selection program (available to the public from the Genome Center at University of Texas South West Medical Center, Dallas TX) is capable of choosing specific primers from megabase sequences and is thus useful for designing primers on a genome-wide scope. The Primer3 primer selection program (available to the public from the Whitehead Institute/MIT Center for Genome Research, 1 o Cambridge MA) allows the user to input a "mispriming library," in which sequences to avoid as primer binding sites are user-specified. Primer3 is useful, in particular, for the selection of oligonucleotides for microarrays. (The source code for the latter two primer selection programs may also be obtained from their respective sources and modified to meet the user's specific needs.) The PrimeGen program (available to the public from the UK Human Genome Mapping Project Resource Centre, Cambridge 15 UK) designs primers based on multiple sequence alignments, thereby allowing selection of primers that hybridize to either the most conserved or least conserved regions of aligned nucleic acid sequences.
Hence, this program is useful for identification of both unique and conserved oligonucleotides and polynucleotide fragments. The oligonucleotides and polynucleotide fragments identified by any of the above selection methods are useful in hybridization technologies, for example, as PCR or sequencing 2 o primers, microarray elements, or specific probes to identify fully or partially complementary polynucleotides in a sample of nucleic acids. Methods of oligonucleotide selection are not limited to those described above.
"Purified" refers to molecules, either polynucleotides or polypeptides that are isolated or separated from their natural environment and are at least 60% free, preferably at least 75 % free, and 2 s most preferably at least 90% free from other compounds with which they are naturally associated.
A "recombinant nucleic acid" is a sequence that is not naturally occurring or has a sequence that is made by an artifcial combination of two or more otherwise separated segments of sequence.
This artificial combination is often accomplished by chemical synthesis or, more commonly, by the artificial manipulation of isolated segments of nucleic acids, e.g., by genetic engineering techniques 3 o such as those described in Sambrook, supra. The term recombinant includes nucleic acids that have been altered solely by addition, substitution, or deletion of a portion of the nucleic acid. Frequently, a recombinant nucleic acid may include a nucleic acid sequence operably linked to a promoter sequence.
Such a recombinant nucleic acid may be part of a vector that is used, for example, to transform a cell.

Alternatively, such recombinant nucleic acids may be part of a viral vector, e.g., based on a vaccinia virus, that could be use to vaccinate a mammal wherein the recombinant nucleic acid is expressed, inducing a protective immunological response in the mammal.
"Regulatory element" refers to a nucleic acid sequence from nontranslated regions of a gene, s and includes enhancers, promoters, introns, and 3' untranslated regions, which interact with host proteins to carry out or regulate transcription or translation.
"Reporter" molecules are chemical or biochemical moieties used for labeling a nucleic acid, an amino acid, or an antibody. They include radionuclides; enzymes; fluorescent, chemiluminescent, or chromogenic agents; substrates; cofactors; inhibitors; magnetic particles; and other moieties known in 1 o the art.
An "RNA equivalent," in reference to a DNA sequence, is composed of the same linear sequence of nucleotides as the reference DNA sequence with the exception that all occurrences of the nitrogenous base thymine are replaced with uracil, and the sugar backbone is composed of ribose instead of deoxyribose.
15 "Sample" is used in its broadest sense. Samples may contain nucleic or amino acids, antibodies, or other materials, and may be derived from any source (e.g., bodily fluids including, but not limited to, saliva, blood, and urine; chromosome(s), organelles, or membranes isolated from a cell;
genomic DNA, RNA, or cDNA in solution or bound to a substrate; and cleared cells or tissues or blots or imprints from such cells or tissues).
2 0 "Specific binding" or ''specifically binding" refers to the interaction between a protein or peptide and its agonist, antibody, antagonist, or other binding partner. The interaction is dependent upon the presence of a particular structure of the protein, e.g., the antigenic determinant or epitope, recognized by the binding molecule. For example, if an antibody is specific for epitope "A," the presence of a polypeptide containing epitope A, or the presence of free unlabeled A, in a reaction 2 s containing free labeled A and the antibody will reduce the amount of labeled A that binds to the antibody.
"Substitution" refers to the replacement of at least one nucleotide or amino acid by a different nucleotide or amino acid.
"Substrate" refers to any suitable rigid or semi-rigid support including, e.g., membranes, filters, 3 o chips, slides, wafers, fibers, magnetic or nonmagnetic beads, gels, tubing, plates, polymers, microparticles or capillaries. The substrate can have a variety of surface forms, such as wells, trenches, pins, channels and pores, to which polynucleotides or polypeptides are bound.
A "transcript image" refers to the collective pattern of gene expression by a particular tissue or cell type under given conditions at a given time.

"Transformation" refers to a process by which exogenous DNA enters a recipient cell.
Transformation may occur under natural or artificial conditions using various methods well known in the art.. Transformation may rely on any known method for the insertion of foreign nucleic acid sequences into a prokaryotic or eukaryotic host cell. The method is selected based on the host cell being transformed.
"Transformants" include stably transformed cells in which the inserted DNA is capable of replication either as an autonomously replicating plasmid or as part of the host chromosome, as well as cells which transiently express inserted DNA or RNA.
A "transgenic organism," as used herein, is any organism, including but not limited to animals 1 o and plants, in which one or more of the cells of the organism contains heterologous nucleic acid introduced by way of human intervention, such as by transgenic techniques well known in the art. The nucleic acid is introduced into the cell, directly or indirectly by introduction into a precursor of the cell, by way of deliberate genetic manipulation, such as by microinjection or by infection with a recombinant virus., mhe term genetic manipulation does not include classical cross-breeding, or in vitro fertilization, but rather is directed to the introduction of a recombinant DNA molecule. The transgenic organisms contemplated in accordance with the present invention include bacteria, cyanobacteria, fungi, and plants and animals. The isolated DNA of the present invention can be introduced into the host by methods known in the art, for example infection, transfection, transformation or transconjugation. Techniques for transferring the DNA of the present invention into such organisms are widely known arid provided in 2 o references such as Sambrook et al. (1989), supra.
A "variant" of a particular nucleic acid sequence is defined as a nucleic acid sequence having at least 25 % sequence identity to the particular nucleic acid sequence over a certain length of one of the nucleic acid sequences using blastn with the "BLAST 2 Sequences" tool Version 2Ø9 (May-07-1999) set at default parameters. Such a pair of nucleic acids may show, for example, at least 30%, at least 2s 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%
or even at least 98% or greater sequence identity over a certain defined length. The variant may result in "conservative" amino acid changes which do not affect structural andlor chemical properties. A
variant may be described as, for example, an "allelic" (as defined above), "splice," "species," or "polymorphic" variant. A splice variant may have significant identity to a reference molecule, but will generally have a greater or lesser 3 o number of polynucleotides due to alternate splicing of exons during mRNA
processing. The corresponding polypeptide may possess additional functional domains or lack domains that are present in the reference molecule. Species variants are polynucleotide sequences that vary from one species to another. The resulting polypeptides generally will have significant amino acid identity relative to each other. A polymorphic variant is a variation in the polynucleotide sequence of a particular gene between 3 s individuals of a given species. Polymorphic variants also may encompass "single nucleotide polymorphisms" (SNPs) in which the polynucleotide sequence varies by one base.
The presence of SNPs may be indicative of, for example, a certain population, a disease state, or a propensity for a disease state.
In an alternative, variants of the polynucleotides of the present invention may be generated s through recombinant methods. One possible method is a DNA shuffling technique such as MOLECULARBREEDING (Maxygen Inc., Santa Clara CA; described in U.S. Patent Number 5,837,458; Chang, C.-C. et al. (1999) Nat. Biotechnol. 17:793-797; Christians, F.C. et al. (1999) Nat.
Biotechnol. 17:259-264; and Crameri, A. et al. (1996) Nat. Biotechnol. 14:315-319) to alter or improve the biological properties of SPTM, such as its biological or enzymatic activity or its ability to bind to ~. o other molecules or compounds. DNA shuffling is a process by which a library of gene variants is produced using PCR-mediated recombination of gene fragments. The library is then subjected to selection or screening procedures that identify those gene variants with the desired properties. These preferred variants may then be pooled and further subjected to recursive rounds of DNA shuffling and selection/screening. Thus, genetic diversity is created through "artificial"
breeding and rapid molecular s s evolution. For example, fragments of a single gene containing random point mutations may be recombined, screened, and then reshuffled until the desired properties are optimized. Alternatively, fragments of a given gene may be recombined with fragments of homologous genes in the same gene fanuly, either from the same or different species, thereby maximizing the genetic diversityof multiple naturally occurring genes in a directed and controllable manner.
2 o A "variant" of a particular polypeptide sequence is defined as a polypeptide sequence having at least 40% sequence identity to the particular polypeptide sequence over a certain length of one of the polypeptide sequences using blastp with the "BLAST 2 Sequences" tool Version 2.0:9 (May-07 1999) set at default parameters. Such a pair of polypeptides may show, for example, at least SO%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, or at least 98% or greater sequence 2 s identity over a certain defined length of one of the polypeptides.
THE INVENTTON
In a particular embodiment, cDNA sequences derived from human tissues and cell lines were aligned based on nucleotide sequence identity and assembled into "consensus"
or "template" sequences 3 o which are designated by the template identification numbers (template IDs) in column 2 of Table 1.
The sequence identification numbers (SEQ ID NOa) corresponding to the template IDs are shown in column 1. Segments of the template sequences are defined by the "start" and "stop" nucleotide positions listed in columns 3 and 4. These segments, when translated in the reading frames indicated in column 5, have similarity to signal peptide (SP) or transmembrane (TM) domain consensus sequences, 3 s as indicated in column 6.

The invention incorporates the nucleic acid sequences of these templates as disclosed in the Sequence Listing and the use of these sequences in the diagnosis and treatment of disease states characterized by defects in cell signaling. The invention further utilizes these sequences in hybridization and amplification technologies, and in particular, in technologies which assess gene expression patterns correlated with specific cells or tissues and their responses in vivo or in vitro to pharmaceutical agents, toxins, and other treatments. In this manner, the sequences of the present invention are used to develop a transcript image for a particular cell or tissue.
Derivation of Nucleic Acid Seauences s o cDNA was isolated from libraries constructed using RNA derived from normal and diseased human tissues and cell lines. The human tissues and cell lines used for cDNA
library construction were selected from a broad range of sources to provide a diverse population of cDNAs representative of gene transcription throughout the human body. Descriptions of the human tissues and cell lines used for cDNA library construction are provided in the LIFESEQ database (Incyte Genomics, Inc. (Incyte), Palo Alto CA). Human tissues were broadly selected from, for example, cardiovascular, dermatologic, endocrine, gastrointestinal, hematopoieticlimmune system, musculoskeletal, neural, reproductive, and urologic sources.
Cell lines used for cDNA library construction were derived from, for example, leukemic cells, teratocarcinomas, neuroepitheliomas, cervical carcinoma, lung fibroblasts, and endothelial cells. Such 2 o cell lines include, for example, THP-1, Jurkat, HUVEC, hNT2, WI38, HeLa, and other cell lines commonly used and available from public depositories (American Type Culture Collection, Manassas VA). Prior to mRNA isolation, cell lines were untreated, treated with a pharmaceutical agent such as 5'-aza-2'-deoxycytidine, treated with an activating agent such as lipopolysaccharide in the case of leukocytic cell lines, or, in the case of endothelial cell lines, subjected to shear stress.
Seguencin~ of the cDNAs Methods for DNA sequencing are well known in the art. Conventional enzymatic methods employ the HIenow fragment of DNA polymerise I, SEQUENASE DNA polymerise (U.S.
Biochemical Corporation, Cleveland OH), Taq polymerise (Applied Biosystems, Foster City CA), 3 o thermostable T7 polymerise (Amersham Pharmacia Biotech, Inc. (Amersham Pharmacia Biotech), Piscataway NJ), or combinations of polymerises and proofreading exonucleases such as those found in the ELONGASE amplification system (Life Technologies Inc. (Life Technologies), Gaithersburg MD), to extend the nucleic acid sequence from an oligonucleotide primer annealed to the DNA template of interest. Methods have been developed for the use of both single-stranded and double-stranded 3 5 templates. Chain termination reaction products may be electrophoresed on urea-polyacrylamide gels and detected either by autoradiography (fox radioisotope-labeled nucleotides) or by fluorescence (for fluorophore-labeled nucleotides). Automated methods for mechanized reaction preparation, sequencing, and analysis using fluorescence detection methods have been developed.
Machines used to prepare cDNAs for sequencing can include the MICROLAB 2200 liquid transfer system (Hamilton Company s (Hamilton), Reno N~, Peltier thermal cycler (PTC200; MJ Research, Inc. (MJ
Research), Watertown MA), and ABI CATALYST 800 thermal cycler (Applied Biosystems). Sequencing can be carried out using, for example, the ABI 373 or 377 (Applied Biosystems) or MEGABACE 1000 (Molecular Dynamics, Inc. (Molecular Dynamics), Sunnyvale CA) DNA sequencing systems, or other automated and manual sequencing systems well known in the art.
1 o The nucleotide sequences of the Sequence Listing have been prepared by current, state-of the-art, automated methods and, as such, may contain occasional sequencing errors or unidentified nucleotides. Such unidentified nucleotides are designated by an N. These infrequent unidentified bases do not represent a hindrance to practicing the invention for those skilled in the art. Several methods ' employing standard recombinant techniques may be used to correct errors and complete the missing is sequence information. (See, e.g., those described in Ausubel, F.M. et al.
(1997) Short Protocols in Molecular Bioloay, John Wiley & Sons, New York NY; and Sambrook, J. et al.
(1989) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Press, Plainview NY.) Assembly of cDNA Secauences , 2 o Human polynucleotide sequences may be assembled using programs or algorithms well known in the art. Sequences to be assembled are related, wholly or in part, and may be derived from a single or many different transcripts. Assembly of the sequences can be performed using such programs as PHRAP (Phils Revised Assembly Program) and the GELVIEW fragment assembly system (GCG), or other methods known in the art.
z s Alternatively, cDNA sequences are used as "component" sequences that are assembled into "template" or "consensus" sequences as follows. Sequence chromatograms are processed, verified, and quality scores are obtained using PHRED. Raw sequences are edited using an editing pathway known as Block I (See, e.g., the LIFESEQ Assembled User Guide, Incyte Genomics, Palo Alto, CA). A series of BLAST comparisons is performed and low-information segments and repetitive elements (e.g., 3 o dinucleotide repeats, Alu repeats, etc.) are replaced by "n's", or masked, to prevent spurious matches.
Mitochondria) and ribosomal RNA sequences are also removed. The processed sequences are then loaded into a relational database management system (RDMS) which assigns edited sequences to existing templates, if available. When additional sequences are added into the RDMS, a process is initiated which modifies existing templates or creates new templates from works in progress (i.e., 3 s nonfinal assembled sequences) containing queued sequences or the sequences themselves. After the new sequences have been assigned to templates, the templates can be merged into bins. If multiple templates exist in one bin, the bin can be split and the templates reannotated.
Once gene bins have been generated based upon sequence alignments, bins are "clone joined"
based upon clone information. Clone joining occurs when the 5' sequence of one clone is present in one bin and the 3' sequence from the same clone is present in a different bin, indicating that the two bins should be merged into a single bin. Only bins which share at least two different clones are merged.
A resultant template sequence may contain either a partial or a full length open reading frame, or all or part of a genetic regulatory element. This variation is due in part to the fact that the full length cDNAs of many genes are several hundred, and sometimes several thousand, bases in length. With 1 o current technology, cDNAs comprising the coding regions of large genes cannot be cloned because of vector limitations, incomplete reverse transcription of the mRNA, or incomplete "second strand"
synthesis. Template sequences may be extended to include additional contiguous sequences derived from the parent RNA transcript using a variety of methods known to those of skill in the art. Extension may thus be used to achieve the full length coding sequence of a gene.
Analysis of the cDNA Sequences The cDNA sequences are analyzed using a variety of programs and algorithms which are well known in the art. (See, e.g., Ausubel, 1997, supra, Chapter 7.7; Meyers, R.A.
(Ed.) (1995) Molecular Biolo~y and Biotechnology, Wiley VCH, New York NY, pp. 856-853; and Table 4.) These analyses 2 o comprise both reading frame determinations, e.g., based on triplet codon periodicity for particular organisms (Fickett, J.W. (1982) Nucleic Acids Res. 10:5303-5318); analyses of potential start and stop codons; and homology searches.
Computer programs known to those of skill in the art for performing computer-assisted searches for amino acid and nucleic acid sequence similarity, include, for example, Basic Local 2s Alignment Search Tool (BLAST; Altschul, S.F. (1993) J. Mol. Evol. 36:290-300; Altschul, S.F. et al.
(1990) J. Mol. Biol. 215:403-410). BLAST is especially useful in determining exact matches and comparing two sequence fragments of arbitrary but equal lengths, whose alignment is locally maximal and for which the alignment score meets or exceeds a threshold or cutoff score set by the user (Karlin, S. et al. (1988) Proc. Natl. Acid. Sci. USA 85:841-845). Using an appropriate search tool (e.g., 3 o BLAST or HMM), GenBank, SwissProt, BLOCKS, PFAM and other databases may be searched for sequences containing regions of homology to a query sptm or SPTM of the present invention.
Other approaches to the identification, assembly, storage, and display of nucleotide and polypeptide sequences are provided in "Relational Database for Storing Biomolecule Information,"
U.S.S.N. 081947,845, filed October 9, 1997; "Project-Based Full-Length Biomolecular Sequence 3 5 Database," U.S,S.N. 08/811,758, filed March 6, 1997; and "Relational Database and System for Storing Information Relating to Biomolecular Sequences," U.S.S.N. 09/034,807, filed March 4, 1998, all of which are incorporated by reference herein in their entirety.
Protein hierarchies can be assigned to the putative encoded polypeptide based on, e.g., motif, BLAST, or biological analysis. Methods for assigning these hierarchies are described, for example, in s "Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data,"
U.S.S.N. 08/812,290, filed March 6, 1997, incorporated herein by reference.
Human Secretory Seguences The sptm of the present invention may be used for a variety of diagnostic and therapeutic purposes. For example, an sptm may be used to diagnose a particular condition, disease, or disorder 1 o associated with cell signaling. Such conditions, diseases, and disorders include, but are not limited to, a cell proliferative disorder such as actinic keratosis, arteriosclerosis, atherosclerosis, bursitis, cirrhosis, hepatitis, mixed connective tissue disease (MCTD), myelofibrosis, paroxysmal nocturnal hemoglobinuria, polycythemia vera, psoriasis, primary thrombocythemia, and cancers including adenocarcinoma, leukemia, lymphoma, melanoma, myeloma, sarcoma, teratocarcinoma, and, in 1 s particular, a cancer of the adrenal gland, bladder, bone, bone marrow, brain, breast, cervix, gall bladder, ganglia, gastrointestinal tract, heart, kidney, liver, lung, muscle, ovary, pancreas, parathyroid, penis, prostate, salivary glands, skin, spleen, testis, thymus, thyroid, and uterus; an immune system disorder such as such as inflammation, actinic keratosis, acquired immunodeficiency syndrome (AIDS), Addison's disease, adult respiratory distress syndrome, allergies, ankylosing spondylitis, 2 o amyloidosis, anemia, arteriosclerosis, asthma, atherosclerosis, autoimmune hemolytic anemia, autoimmune thyroiditis, bronchitis, bursitis, cholecystitis, cirrhosis, contact dermatitis, Crohn's disease, atopic dermatitis, dermatomyositis, diabetes mellitus, emphysema, erythroblastosis fetalis, erythema nodosum, atrophic gastritis, glomerulonephritis, Goodpasture's syndrome, gout, Graves' disease, Hashimoto's thyroiditis, paroxysmal nocturnal hemoglobinuria, hepatitis, hypereosinophilia, 2 5 irritable bowel syndrome, episodic lymphopenia with lymphocytotoxins, mixed connective tissue disease (MCTD), multiple sclerosis, myasthenia gravis, myocardial or pericardial inflammation, myelofibrosis, osteoarthritis, osteoporosis, pancreatitis, polycythemia vera, polymyositis, psoriasis, Reiter's syndrome, rheumatoid arthritis, scleroderma, Sjogren's syndrome, systemic anaphylaxis, systemic lupus erythematosus, systemic sclerosis, primary thrombocythemia, thrombocytopenic 3 o purpura, ulcerative colitis, uveitis, Werner syndrome, complications of cancer, hemodialysis, and extracorporeal circulation, trauma, and hematopoietic cancer including lymphoma, leukemia, and myeloma; and a neurological disorder such as epilepsy, ischemic cerebrovascular disease, stroke, cerebral neoplasms, Alzheimer's disease, Pick's disease, Huntington's disease, dementia, Parkinson's disease and other extrapyramidal disorders, amyotrophic lateral sclerosis and other motor neuron 3 5 disorders, progressive neural muscular atrophy, retinitis pigmentosa, hereditary ataxias, multiple sclerosis and other demyelinating diseases, bacterial and viral meningitis, brain abscess, subdural empyema, epidural abscess, suppurative intracranial thrombophlebitis, myelitis and radiculitis, viral central nervous system disease, prion diseases including kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia, nutritional and metabolic diseases s of the nervous system, neurofibromatosis, tuberous sclerosis, cerebelloretinal hemangioblastomatosis, encephalotrigeminal syndrome, mental retardation and other developmental disorder of the central nervous system, cerebral palsy, a neuroskeletal disorder, an autonomic nervous system disorder, a cranial nerve disorder, a spinal cord disease, muscular dystrophy and other neuromuscular disorder, a peripheral nervous system disorder, dermatomyositis and polymyositis, inherited, metabolic, endocrine, s o and toxic myopathy, myasthenia gravis, periodic paralysis, a mental disorder including mood, anxiety, and schizophrenic disorder, seasonal affective disorder (SAD), akathesia, amnesia, catatonia, diabetic neuropathy, tardive dyskinesia, dystonias, paranoid psychoses, postherpetic neuralgia, and Tourette's disorder. The sptm can be used to detect the presence of, or to quantify the amount of, an sptm-related polynucleotide in a sample. This information is then compared to information obtained from appropriate s s reference samples, and a diagnosis is established. Alternatively, a polynucleotide complementary to a given sptm can inhibit or inactivate a therapeutically relevant gene related to the sptm.
Analysis of sptm Expression Patterns The expression of sptm may be routinely assessed by hybridization-based methods to 2 o determine, for example, the tissue-specificity, disease-specificity, or developmental stage-specificity of sptm expression. For example, the level of expression of sptm may be compared among different cell types or tissues, among diseased and normal cell types or tissues, among cell types or tissues at different developmental stages, or among cell types or tissues undergoing various treatments. This type of analysis is useful, for example, to assess the relative levels of sptm expression in fully or partially 2 s differentiated cells or tissues, to determine if changes in sptm expression levels are correlated with the development or progression of specific disease states, and to assess the response of a cell or tissue to a specific therapy, for example, in pharmacological or toxicological studies.
Methods for the analysis of sptm expression are based on hybridization and amplification technologies and include membrane-based procedures such as northern blot analysis, high-throughput procedures that utilize, for example, 3 o microarrays, and PCR-based procedures.
Hybridization and Genetic Analysis The sptm, their fragments, or complementary sequences, may be used to identify the presence of and/or to determine the degree of similarity between two (or more) nucleic acid sequences. The sptm a 5 may be hybridized to naturally occurring or recombinant nucleic acid sequences under appropriately selected temperatures and salt concentrations. Hybridization with a probe based on the nucleic acid sequence of at least one of the sptm allows for the detection of nucleic acid sequences, including genomic sequences, which are identical or related to the sptm of the Sequence Listing. Probes may be selected from non-conserved or unique regions of at least one of the polynucleotides of SEQ ID NO:1-79 and tested for their ability to identify or amplify the target nucleic acid sequence using standard protocols.
Polynucleotide sequences that are capable of hybridizing, in particular, to those shown in SEQ
ID NO:l-79 and fragments thereof, can be identified using various conditions of stringency. (See, e.g., Wahl, G.M. and S.L. Berger (1987) Methods Enzymol. 152:399-407; Kimmel, A.R.
(1987) Methods so Enzymol. 152:507-511.) Hybridization conditions are discussed in "Definitions."
A probe for use in Southern or northern hybridization may be derived from a fragment of an sptm sequence, or its complement, that is up to several hundred nucleotides in length and is either single-stranded or double-stranded. Such probes may be hybridized in solution to biological materials such as plasmids, bacterial, yeast, or human artificial chromosomes, cleared or sectioned tissues, or to s s artificial substrates containing sptm. Microarrays are particularly suitable for identifying the presence of and detecting the level of expression for multiple genes of interest by examining gene expression correlated with, e.g., various stages of development, treatment with a drug or compound, or disease progression. An array analogous to a dot or slot blot may be used to arrange and link polynucleotides to the surface of a substrate using one or more of the following: mechanical (vacuum), chemical, 2 o thermal, or UV bonding procedures. Such an array may contain any number of sptm and may be produced by hand or by using available devices, materials, and machines.
Microarrays may be prepared, used, and analyzed using methods known in the art. (See, e.g., Brennan, T.M, et al. (1995) U.S. Patent No. 5,474,796; Schena, M. et al.
(1996) Proc. Natl. Acad. Sci.
USA 93:10614-10619; Baldeschweiler et al. (1995) PCT application W095/251116;
Shalom D. et al.
2s (1995) PCT application W095/35505; Heller, R.A. et al. (1997) Proc. Natl.
Acad. Sci. USA 94:2150-2155; and Heller, M.J. et al. (1997) U.S. Patent No. 5,605,662.) Probes may be labeled by either PCR or enzymatic techniques using a variety of commercially available reporter molecules. For example, commercial kits are available for radioactive and chemiluminescent labeling (Amersham Pharmacia Biotech) and for alkaline phosphatase labeling (Life 3 o Technologies). Alternatively, sptm may be cloned into commercially available vectors for the production of RNA probes. Such probes may be transcribed in the presence of at least one labeled nucleotide (e.g., 32P-ATP, Amersham Pharmacia Biotech).
Additionally the polynucleotides of SEQ ID N0:1-79 or suitable fragments thereof can be used to isolate full length cDNA sequences utilizing hybridization and/or amplification procedures well a s known in the art, e.g., cDNA library screening, PCR amplification, etc.
The molecular cloning of such full length cDNA sequences may employ the method of cDNA library screening with probes using the hybridization, stringency, washing, and probing strategies described above and in Ausubel, supra, Chapters 3, 5, and 6. These procedures may also be employed with genomic libraries to isolate genomic sequences of sptm in order to analyze, e.g., regulatory elements.
Genetic Mapping Gene identification and mapping are important in the investigation and treatment of almost all to conditions, diseases, and disorders. Cancer, cardiovascular disease, Alzheimer's disease, arthritis, diabetes, and mental illnesses are of particular interest. Each of these conditions is more complex than the single gene defects of sickle cell anemia or cystic fibrosis, with select groups of genes being predictive of predisposition for a particular condition, disease, or disorder.
For example;
cardiovascular disease may result from malfunctioning receptor molecules that fail to clear cholesterol s s from the bloodstream, and diabetes may result when a particular individual's immune system is activated by an infection and attacks the insulin-producing cells of the pancreas. In some studies, Alzheimer's disease has been linked to a gene on chromosome 21; other studies predict a different gene and location. Mapping of disease genes is a complex and reiterative process and generally proceeds from genetic linkage analysis to physical mapping.
2 o As a condition is noted among members of a family, a genetic linkage map traces parts of chromosomes that are inherited in the same pattexn as the condition.
Statistics link the inheritance of particular conditions to particular regions of chromosomes, as defined by RFLP
or other markers.
(See, for example, Lander, E. S. and Botstein, D. (1986) Proc. Natl. Acad.
Sci. USA 83:7353-7357.) Occasionally, genetic markers and their locations are known from previous studies, More often, 2 s however, the markers are simply stretches of DNA that differ among individuals. Examples of genetic linkage maps can be found in various scientific journals or at the Online Mendelian Inheritance in Man (OMIM) World Wide Web site.
In another embodiment of the invention, sptm sequences may be used to generate hybridization probes useful in chromosomal mapping of naturally occurring genomic sequences.
Either coding or 3 o noncoding sequences of sptm may be used, and in some instances, noncoding sequences may be preferable over coding sequences. For example, conservation of an sptm coding sequence among members of a multi-gene family may potentially cause undesired cross hybridization during chromosomal mapping. The sequences may be mapped to a particular chromosome, to a specific region of a chromosome, or to artificial chromosome constructions, e.g., human artificial chromosomes 35 (HACs), yeast artificial chromosomes (YACs), bacterial artificial chromosomes (BACs), bacterial P1 constructions, or single chromosome cDNA libraries. (See, e.g., Harrington, J.J. et al. (1997) Nat.
Genet. 15:345-355; Price, C.M. (1993) Blood Rev. 7:127-134; and Trask, B.J.
(1991) Trends Genet.
7:149-154.) Fluorescent in situ hybridization (FISH) may be correlated with other physical chromosome s mapping techniques and genetic map data. (See, e.g., Meyers, supra, pp. 965-968.) Correlation between the location of sptm on a physical chromosomal map and a specific disorder, or a predisposition to a specific disorder, may help define the region of DNA
associated with that disorder.
The sptm sequences may also be used to detect polymorphisms that are genetically linked to the inheritance of a particular condition, disease, or disorder.
~ o In situ hybridization of chromosomal preparations and genetic mapping techniques, such as linkage analysis using established chromosomal markers, may be used for extending existing genetic maps. Often the placement of a gene on the chromosome of another mammalian species, such as mouse, may reveal associated markers even if the number or arm of the corresponding human chromosome is not known. These new marker sequences can be mapped to human chromosomes and s s may provide valuable information to investigators sear ching for disease genes using positaonal cloning or other gene discovery techniques. Once a disease ox syndrome has been crudely correlated by genetic linkage with a particular genomic region, e.g., ataxia-telangiectasia to 11q22-23, any sequences mapping to that area may represent associated or regulatory. genes for further investigation. (See, e.g., Gatti, R.A. et al. (1988) Nature 336:577-580.) The nucleotide sequences of the subject invention may 2 o also be used to detect differences in chromosomal architecture due to translocation, inversion, etc., among normal, carrier, or affected individuals.
Once a disease-associated gene is mapped to a chromosomal region, the gene must be cloned in order to identify mutations or other alterations (e.g., translocations or inversions) that may be correlated with disease. This process requires a physical map of the chromosomal region containing the disease-2 s gene of interest along with associated markers. A physical map is necessary for determining the nucleotide sequence of arid order of marker genes on a particular chromosomal region. Physical mapping techniques are well known in the art and require the generation of overlapping sets of cloned DNA fragments from a particular organelle, chromosome, or genome. These clones are analyzed to reconstruct and catalog their order. Once the position of a marker is determined, the DNA from that 3 o region is obtained by consulting the catalog and selecting clones from that region. The gene of interest is located through positional cloning techniques using hybridization or similar methods.
Diagnostic Uses The sptm of the present invention may be used to design probes useful in diagnostic assays.
3 5 Such assays, well known to those skilled in the art, may be used to detect or confirm conditions, disorders, or diseases associated with abnormal levels of sptm expression.
Labeled probes developed from sptm sequences are added to a sample under hybridizing conditions of desired stringency. In some instances, sptm, or fragments or oligonucleotides derived from sptm, may be used as primers in amplification steps prior to hybridization. The amount of hybridization complex formed is quantified s and compared with standards for that cell or tissue. If sptm expression varies significantly from the standard, the assay indicates the presence of the condition, disorder, or disease. Qualitative or quantitative diagnostic methods may include northern, dot blot, or other membrane or dip-stick based technologies or multiple-sample format technologies such as PCR, enzyme-linked immunosorbent assay (ELISA)-like, pin, or chip-based assays.
~ o The probes described above may also be used to monitor the progress of conditions, disorders, or diseases associated with abnormal levels of sptm expression, or to evaluate the efficacy of a particular therapeutic treatment. The candidate probe may be identified from the sptm that are specific to a given human tissue and have not been observed in GenBank or other genome databases. Such a probe may be used in animal studies, preclinical tests, clinical trials, or in monitoring the treatment of 15 an individual patient. In a typical process, standard expression is established by methods well known in the art for use as a basis of comparison, samples from patients affected by the disorder or disease are combined with the probe to evaluate any deviation from the standard profile, and a therapeutic agent is administered and effects are monitored to generate a treatment profile.
Efficacy is evaluated by determining whether the expression progresses toward or returns to the standard normal pattern.
2 o Treatment profiles may be generated over a period of several days or several months. Statistical methods well known to those skilled in the art may be use to determine the significance of such therapeutic agents.
The polynucleotides are also useful for identifying individuals from minute biological samples, for example, by matching the RFLP pattern of a sample's DNA to that of an individual's DNA. The 2 5 polynucleotides of the present invention can also be used to determine the actual base-by-base DNA
sequence of selected portions of an individual's genome. These sequences can be used to prepare PCR
primers for amplifying and isolating such selected DNA, which can then be sequenced. Using this technique, an individual can be identified through a unique set of DNA
sequences. Once a unique ID
database is established for an individual, positive identification of that individual can be made from 3 o extremely small tissue samples.
In a particular aspect, oligonucleotide primers derived from the sptm of the invention may be used to detect single nucleotide polymorphisms (SNPs). SNPs are substitutions, insertions and deletions that are a frequent cause of inherited or acquired genetic disease in humans. Methods of SNP
detection include, but are not limited to, single-stranded conformation polymorphism (SSCP) and 3 5 fluorescent SSCP (fSSCP) methods. In SSCP, oligonucleotide primers derived from sptm are used to amplify DNA using the polymerase chain reaction (PCR). The DNA may be derived, for example, from diseased or normal tissue, biopsy samples, bodily fluids, and the like.
SNPs in the DNA cause differences in the secondary and tertiary structures of PCR products in single-stranded form, and these differences are detectable using gel electrophoresis in non-denaturing gels.
In fSCCP, the s oligonucleotide primers are fluorescently labeled, which allows detection of the amplimers in high-throughput equipment such as DNA sequencing machines. Additionally, sequence database analysis methods, termed in silico SNP (isSNP), are capable of identifying polymorphisms by comparing the sequences of individual overlapping DNA fragments which assemble into a common consensus sequence. These computer-based methods filter out sequence variations due to laboratory preparation s o of DNA and sequencing errors using statistical models and automated analyses of DNA sequence chromatograms. In the alternative, SNPs may be detected and characterized by mass spectrometry using, for example, the high throughput MASSARRAY system (Sequenom, Inc., San Diego CA).
DNA-based identification techniques are critical in forensic technology. DNA
sequences taken from very small biological samples such as tissues, e.g., hair or skin, or body fluids, e.g., blood, saliva, 15 semen, etc., can be amplified using, e.g., PCR, to identify individuals.
(See, e.g., Erlich, H. (1992) PCR Technolo~y, Freeman and Co., New York, NY). Similarly, polynucleotides of the present invention can be used as polymorphic markers.
There is also a need for reagents capable of identifying the source of a particular tissue.
Appropriate reagents can comprise, fox example, DNA probes or primers prepared from the sequences 2 0 of the present invention that are specific for particular tissues. Panels of such reagents can identify tissue by species and/or by organ type. In a similar fashion, these reagents can be used to screen tissue cultures for contamination.
The polynucleotides of the present invention can also be used as molecular weight markers on nucleic acid gels or Southern blots, as diagnostic probes for the presence of a specific mRNA in a 2 s particular cell type, in the creation of subtracted cDNA libraries which aid in the discovery of novel polynucleotides, in selection and synthesis of oligomers for attachment to an array or other support, and as an antigen to elicit an immune response.
Disease Model Systems Using s~tm The polynucleotides encoding SPTM or their mammalian homologs may be "knocked out" in 3 o an animal model system using homologous recombination in embryonic stem (ES) cells. Such techniques are well known in the art and are useful for the generation of animal models of human disease. (See, e.g., U.S. Patent Number 5,175,383 and U.S. Patent Number 5,767,337.) For example, mouse ES cells, such as the mouse 12,9/SvJ cell line, are derived from the early mouse embryo and grown in culture. The ES cells are transformed with a vector containing the gene of interest disrupted 35 by a marker gene, e.g., the neomycin phosphotransferase gene (neo;
Capecchi, M.R. (1989) Science 244:1288-1292). The vector integrates into the corresponding region of the host genome by homologous recombination. Alternatively, homologous recombination takes place using the Cre-loxP
system to knockout a gene of interest in a tissue- or developmental stage-specific manner (March, J.D.
(1996) Clin. Invest. 97:1999-2002; Wagner, K.U. et al. (1997) Nucleic Acids Res. 25:4323-4330).
s Transformed ES cells are identified and microinjected into mouse cell blastocysts such as those from the C57BL/6 mouse strain. The blastocysts are surgically transferred to pseudopregnant dams, and the resulting chimeric progeny are genotyped and bred to produce heterozygous or homozygous strains.
Transgenic animals thus generated may be tested with potential therapeutic or toxic agents.
The polynucleotides encoding SPTM may also be manipulated in vitro in ES cells derived from s o human blastocysts. Human ES cells have the potential to differentiate into at least eight separate cell lineages including endoderm, mesoderm, and ectodermal cell types. These cell lineages differentiate into, for example, neural cells, hematopoietic lineages, and cardiomyocytes (Thomson, J.A. et al. (1998) Science 282:1145-1147).
The polynucleotides encoding SPTM of the invention can also be used to create "knockin"
15 humanized animals (pigs) or transgenic animals (mice or rats) to model human disease. With knockin technology, a region of sptm is injected into animal ES cells, and the injected sequence integrates into the animal cell genome. Transformed cells are injected into blastulae, and the blastulae are implanted as described above. Transgenic progeny or inbred lines are studied and treated with potential pharmaceutical agents to obtain information on treatment of a human disease.
Alternatively, a mammal 2 o inbred to overexpress sptm, resulting, e.g., in the secretion of SPTM in its milk, may also serve as a convenient source of that protein (Janne, J. et al. (1998) Biotechnol. Annu.
Rev. 4:55-74).
Screening Assays SPTM encoded by polynucleotides of the present invention may be used to screen for molecules 2 s that bind to or are bound by the encoded polypeptides. The binding of the polypeptide and the molecule may activate (agonist), increase, inhibit (antagonist), or decrease activity of the polypeptide or the bound molecule. Examples of such molecules include antibodies, oligonucleotides, proteins (e.g., receptors), or small molecules.
Preferably, the molecule is closely related to the natural ligand of the polypeptide, e.g., a ligand 3 0 or fragment thereof, a natural substrate, or a structural or functional mimetic. (See, Coligan et al., (1991) Current Protocols in Immunology 1(2): Chapter 5.) Similarly, the molecule can be closely related to the natural receptor to which the polypeptide binds, or to at least a fragment of the receptor, e.g., the active site. In either case, the molecule can be rationally designed using known techniques.
Preferably, the screening for these molecules involves producing appropriate cells which express the 3 5 polypeptide, either as a secreted protein or on the cell membrane.
Preferred cells include cells from mammals, yeast, Drosophila, or E. coli. Cells expressing the polypeptide or cell membrane fractions which contain the expressed polypeptide are then contacted with a test compound and binding, stimulation, or inhibition of activity of either the polypeptide or the molecule is analyzed.
An assay may simply test binding of a candidate compound to the polypeptide, wherein binding s is detected by a fluorophore, radioisotope, enzyme conjugate, or other detectable label. Alternatively, the assay may assess binding in the presence of a labeled competitor.
Additionally, the assay can be carried out using cell-free preparations, polypeptide/molecule affixed to a solid support, chemical libraries, or natural product mixtures.
The assay may also simply comprise the steps of mixing a candidate compound with a solution containing a polypeptide, measuring 2 o polypeptide/molecule activity or binding, and comparing the polypeptide/molecule activity or binding to a standard.
Preferably, an ELISA assay using, e.g., a monoclonal or polyclonal antibody, can measure polypeptide level in a sample. The antibody can measure polypeptide level by either binding, directly or indirectly, to the polypeptide or by competing with the polypeptide for a substrate.
15 All of the above assays can be used in a diagnostic or prognostic context.
The molecules discovered using these assays can be used to treat disease or to bring about a particular result in a patient (e.g., blood vessel growth) by activating or inhibiting the polypeptide/molecule. Moreover, the assays can discover agents which may inhibit or enhance the production of the polypeptide from suitably maiupulated cells or tissues.
Transcript Imaging and Toxicological Testing Another embodiment relates to the use of sptm to develop a transcript image of a tissue or cell type. A transcript image represents the global pattern of gene expression by a particular tissue or cell type. Global gene expression patterns are analyzed by quantifying the number of expressed genes and 2 5 their relative abundance under given conditions and at a given time. (See Seilhamer et al., "Comparative Gene Transcript Analysis," U.S. Patent Number 5,840,484, expressly incorporated by reference herein.) Thus a transcript image may be generated by hybridizing the polynucleotides of the present invention or their complements to the totality of transcripts or reverse transcripts of a particular tissue or cell type. In one embodiment, the hybridization takes place in high-throughput format, 3 o wherein the polynucleotides of the present invention or their complements comprise a subset of a plurality of elements on a microarray. The resultant transcript image would provide a profile of gene activity pertaining to cell signaling.
Transcript images which profile sptm expression may be generated using transcripts isolated from tissues, cell lines, biopsies, or other biological samples. The transcript image may thus reflect sptm expression in vivo, as in the case of a tissue or biopsy sample, or in vitro, as in the case of a cell line.
Transcript images which profile sptm expression may also be used in conjunction with in vitro model systems and preclinical evaluation of pharmaceuticals, as well as toxicological testing of s industrial and naturally-occurring environmental compounds. All compounds induce characteristic gene expression patterns, frequently termed molecular fingerprints or toxicant signatures, which are indicative of mechanisms of action and toxicity (Nuwaysir, E. F. et al. (1999) Mol. Carcinog. 24:153-159; Steiner, S. and Anderson, N. L. (2000) Toxicol. Lett. 112-213:467-71, expressly incorporated by reference herein). If a test compound has a signature similar to that of a compound with known s o toxicity, it is likely to share those toxic properties. These fingerprints or signatures are most useful and refined when they contain expression information from a large number of genes and gene families.
Ideally, a genome-wide measurement of expression provides the highest quality signature. Even genes whose expression is not altered by any tested compounds are important as well, as the levels of expression of these genes are used to normalize the rest of the expression data. The normalization 15 procedure is useful for comparison of expression data after treatment with different compounds. While the assignment of gene function to elements of a toxicant signature aids in interpretation of toxicity mechanisms, knowledge of gene function is not necessary for the statistical matching of signatures which leads to prediction of toxicity. (See, for example, Press Release 00-02 from the National Institute of Environmental Health Sciences, released February 29, 2000, available at 2o http://www.niehs.nih.gov/oc/news/toxchip.htm.) Therefore, it is important and desirable in toxicological screening using toxicant signatures to include all expressed gene sequences.
In one embodiment, the toxicity of a test compound is assessed by treating a biological sample containing nucleic acids with the test compound. Nucleic acids that are expressed in the treated biological sample are hybridized with one or more probes specific to the polynucleotides of the 2 s present invention, so that transcript levels corresponding to the polynucleotides of the present invention may be quantified. The transcript levels in the treated biological sample are compared with levels in an untreated biological sample. Differences in the transcript levels between the two samples are indicative of a toxic response caused by the test compound in the treated sample.
Another particular embodiment relates to the use of SPTM encoded by polynucleotides of the 3 o present invention to analyze the proteome of a tissue or cell type. The term proteome refers to the global pattern of protein expression in a particular tissue or cell type. Each protein component of a proteome can be subjected individually to further analysis. Proteome expression patterns, or profiles, are analyzed by quantifying the number of expressed proteins and their relative abundance under given conditions and at a given time. A profile of a cell's proteome may thus be generated by separating and 3 s analyzing the polypeptides of a particular tissue or cell type. In one embodiment, the separation is achieved using two-dimensional gel electrophoresis, in which proteins from a sample are separated by isoelectric focusing in the first dimension, and then according to molecular weight by sodium dodecyl sulfate slab geI electrophoresis in the second dimension (Steiner and Anderson, supra). The proteins are visualized in the gel as discrete and uniquely positioned spots, typically by staining the gel with an s agent such as Coomassie Blue or silver or fluorescent stains. The optical density of each protein spot is generally proportional to the level of the protein in the sample. The optical densities of equivalently positioned protein spots from different samples, for example, from biological samples either treated or untreated with a test compound or therapeutic agent, are compared to identify any changes in protein spot density related to the treatment. The proteins in the spots are partially sequenced using, for s o example, standard methods employing chemical or enzymatic cleavage followed by mass spectrometry.
The identity of the protein in a spot may be determined by comparing its partial sequence, preferably of at least 5 contiguous amino acid residues, to the polypeptide sequences of the present invention. In some cases, further sequence data may be obtained for definitive protein identification.
A proteomic profile may also be generated using antibodies specific for SPTM
to quantify the ~ s levels of SPTM expression. In one embodiment, the antibodies are used as elements on a microarray, and protein expression levels are quantified by exposing the microarray to the sample and detecting the levels of protein bound to each array element (Lueking, A. et al. (1999) Anal.
Biochem. 270:103-11;
Mendoze, L. G. et al. ( 1999) Biotechniques 27:778-88). Detection may be performed by a variety of methods known in the art, for example, by reacting the proteins in the sample with a thiol- or amino-2 o reactive fluorescent compound and detecting the amount of fluorescence bound at each array element.
Toxicant signatures at the proteome level are also useful for toxicological screening, and should be analyzed in parallel with toxicant signatures at the transcript level.
There is a poor correlation between transcript and protein abundances for some proteins in some tissues (Anderson, N. L. and Seilhamer, J. (1997) Electrophoresis 18:533-537), so proteome toxicant signatures may be useful in the z s analysis of compounds which do not significantly affect the transcript image, but which alter the proteomic profile. In addition, the analysis of transcripts in body fluids is difficult, due to rapid degradation of mRNA, so proteomic profiling may be more reliable and informative in such cases.
In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins that are expressed in the treated biological 3 o sample are separated so that the amount of each protein can be quantified.
The amount of each protein is compared to the amount of the corresponding protein in an untreated biological sample. A difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample. Individual proteins are identified by sequencing the amino acid residues of the individual proteins and comparing these partial sequences to the SPTM encoded by polynucleotides of 3 5 the present invention.

In another embodiment, the toxicity of a test compound is assessed by treating a biological sample containing proteins with the test compound. Proteins from the biological sample are incubated with antibodies specific to the SPTM encoded by polynucleotides of the present invention. The amount of protein recognized by the antibodies is quantified. The amount of protein in the treated biological s sample is compared with the amount in an untreated biological sample. A
difference in the amount of protein between the two samples is indicative of a toxic response to the test compound in the treated sample.
Transcript images may be used to profile sptm expression in distinct tissue types. This process can be used to determine cell signaling activity in a particular tissue type relative to this activity in a ~. o different tissue type. Transcript images may be used to generate a profile of sptm expression characteristic of diseased tissue. Transcript images of tissues before and after treatment may be used for diagnostic purposes, to monitor the progression of disease, and to monitor the efficacy of drug treatments for diseases which affect cell signaling activity.
Transcript images of cell lines can be used to assess cell signaling activity and/or to identify 1 s cell lines that lack or misregulate this activity. Such Bell lines may then be treated with pharmaceutical agents, and a transcript image following treatment may indicate the efficacy of these agents in restoring desired levels of this activity. A similar approach may be used to assess the toxicity of pharmaceutical agents as reflected by undesirable changes in cell signaling activity.
Candidate pharmaceutical agents may be evaluated by comparing their associated transcript images with those of pharmaceutical agents 2 0 of known effectiveness.
Antisense Molecules The polynucleotides of the present invention are useful in antisense technology. Antisense technology or therapy relies on the modulation of expression of a target protein through the specific 2 s binding of an antisense sequence to a target sequence encoding the target protein or directing its expression. (See, e.g., Agrawal, S., ed. (1996) Antisense Therapeutics, Humana Press Inc., Totawa NJ; Alama, A. et al. (1997) Pharmacol. Res. 36(3):171-178; Crooke, S.T. (1997) Adv. Pharmacol.
40:1-49; Sharma, H.W. and R. Narayanan (1995) Bioessays 17(12):1055-1063; and Lavrosky, Y, et al. (1997) Biochem. Mol. Med. 62(1):11-22.) An antisense sequence is a polynucleotide sequence 3 o capable of specifically hybridizing to at least a portion of the target sequence. Antisense sequences bind to cellular mRNA and/or genomic DNA, affecting translation and/or transcription. Antisense sequences can be DNA, RNA, or nucleic acid mimics and analogs. (See, e.g., Rossi, J.J. et al. (1991) Antisense Res. Dev. 1(3):285-288; Lee, R. et al. (1998) Biochemistry 37(3):900-1010; Pardridge, W.M. et al. (1995) Proc. Natl. Acad. Sci. USA 92(12):5592-5596; and Nielsen, P. E. and Haaima, G.
3 5 (1997) Chem. Soc. Rev. 96:73-78.) Typically, the binding which results in modulation of expression occurs through hybridization or binding of complementary base pairs. Antisense sequences can also bind to DNA duplexes through specific interactions in the major groove of the double helix.
The polynucleotides of the present invention and fragments thereof can be used as antisense sequences to modify the expression of the polypeptide encoded by sptm. The antisense sequences can s be produced ex vivo, such as by using any of the ABI nucleic acid synthesizer series (Applied Biosystems) or other automated systems known in the art. Antisense sequences can also be produced biologically, such as by transforming an appropriate host cell with an expression vector containing the sequence of interest. (See, e.g., Agrawal, supra.) In therapeutic use, any gene delivery system suitable for introduction of the antisense sequences ~ o into appropriate target cells can be used. Antisense sequences can be delivered intracellularly in the form of an expression plasmid which, upon transcription, produces a sequence complementary to at least a portion of the cellular sequence encoding the target protein. (See, e.g., Slater, J.E., et al. (1998) J. Allergy Clin. Immunol. 102(3):469-475; and Scanlon, K.J., et al. (1995) 9(13):1288-1296.) Antisense sequences can also be introduced intracellularly through the use of viral vectors, such as s5 retrovirus and adeno-associated virus vectors. (See, e.g., Miller, A.D.
(1990) Blood 76:271; Ausubel, F.M. et al. (1995) Current Protocols in Molecular Biolo~y, John Wiley & Sons, New York NY; Uckert, W. and W. Walther (1994) Pharmacol. Ther. 63(3):323-347.) Other gene delivery mechanisms include liposome-derived systems, artificial viral envelopes, and other systems known in the art. (See, e.g., Rossi, J.J. (1995) Br. Med. Bull. 51(1):217-225; Boado, R.J. et al: (1998) J.
Pharm. Sci.' 87(11):1308-20 1315; and Morris, M.C. et al, (1997) Nucleic Acids Res. 25(14):2730-2736.) Expression In order to express a biologically active SPTM, the nucleotide sequences encoding SPTM or fragments thereof may be inserted into an appropriate expression vector, i.e., a vector which contains 25 the necessary elements for transcriptional and translational.control of the inserted coding sequence in a suitable host. Methods which are well known to those skilled in the art may be used to construct expression vectors containing sequences encoding SPTM and appropriate transcriptional and txanslational control elements. These methods include in vitro recombinant DNA
techniques, synthetic techniques, and in vivo genetic recombination. (See, e.g., Sambrook, su ra, Chapters 4, 8, 16, and 17;
3 o and Ausubel, supra, Chapters 9, 10, 13, and 16.) A variety of expression vector/host systems may be utilized to contain and express sequences encoding SPTM. These include, but are not limited to, microorganisms such as bacteria transformed with recombinant bacteriophage, plasmid, or cosmid DNA expression vectors;
yeast transformed with yeast expression vectors; insect cell systems infected with viral expression vectors (e.g., baculovirus);
3 s plant cell systems transformed with viral expression vectors (e.g., cauliflower mosaic virus, CaMV, or tobacco mosaic virus, TMV) or with bacterial expression vectors (e.g., Ti or pBR322 plasmids); or animal (mammalian) cell systems. (See, e.g., Sambrook, supra; Ausubel, 1995, su ra, Van Heeke, G.
and S.M. Schuster (1989) J. Biol. Chem. 264:5503-5509; Bitter, G.A. et al.
(1987) Methods Enzymol.
153:516-544; Scorer, C.A. et al. (1994) Bio/Technology 12:181-184; Engelhard, E.K. et al. (1994) s Proc. Natl. Acad. Sci. USA 91:3224-3227; Sandig, V. et al. (1996) Hum. Gene Ther. 7:1937-1945;
Takamatsu, N. (1987) EMBO J. 6:307-311; Coruzzi, G. et al. (1984) EMBO J.
3:1671-1680; Brogue, R. et al. (1984) Science 224:838-843; Winter, J. et al. (1991) Results Probl.
Cell Differ. 17:85-105;
The McGraw Hill Yearbook of Science and Technolo~y (1992) McGraw Hill, New York NY, pp.
191-196; Logan, J. and T. Shenk (1984) Proc. Natl. Acad. Sci. USA 81:3655-3659; and Harrington, 1 o J.J. et al. (1997) Nat. Genet. 15:345-355.) Expression vectors derived from retroviruses, adenoviruses, or herpes or vaccinia viruses, or from various bacterial plasmids, may be used fox delivery of nucleotide sequences to the targeted organ, tissue, or cell population. (See, e.g., Di Nicola, M. et al. (1998) Cancer Gen. Ther. 5(6):350-356; Yu, M. et al., (1993) Proc. Natl. Acad. Sci.
USA 90(13):6340-6344;
Buller, R,M. et a1. (1985) Nature 317(6040):813-815; McGregor, D.P. et al.
(1994) Mol. Immunol.
s5 31(3):219-226; and Verma, LM. and N. Somia (1997) Nature 389:239-242.) The invention is not limited by the host cell employed.
For long term production of recombinant proteins in mammalian systems, stable expression of SPTM in cell lines is preferred. For example, sequences encoding SPTM can be transformed into cell lines using expression vectors which may contain viral origins of replication and/or endogenous 2 o expression elements and a selectable marker gene on the same or on a separate vector. Any number of selection systems may be used to recover transformed cell lines. (See, e.g., Wigler, M. et al. (1977) Cell 11:223-232; Lowy, I. et al. (1980) CeII 22:817-823.; Wigler, M. et al.
(1980) Proc. Natl. Acad.
Sci. USA 77:3567-3570; Colbere-Garapin, F. et al. (1981) J. Mol. Biol. 150:1-14; Hartman, S.C. and R.C.Mulligan (1988) Proc. Natl. Acad. Sci. USA 85:8047-8051; Rhodes, C.A.
(1995) Methods Mol.
2 s Biol, 55:121-131.) Therapeutic Uses of sptm The polynucleotides encoding SPTM of the invention may be used for somatic or germline gene therapy. Gene therapy may be performed to (i) correct a genetic deficiency (e.g., in the cases of severe 3 o combined immunodeficiency (SCID)-X1 disease characterized by X-linked inheritance (Cavazzana-Calvo, M. et al. (2000) Science 288:669-672), severe combined immunodeficiency syndrome associated with an inherited adenosine deaminase (ADA) deficiency (Blaese, R.M, et al.
(1995) Science 270:475-480; Bordignon, C. et al. (1995) Science 270:470-475), cystic fibrosis (Zabner, J. et al. (1993) Cell 75:207-216; Crystal, R.G. et al. (1995) Hum. Gene Therapy 6:643-666; Crystal, R.G. et al. (1995) 3 5 Hum. Gene Therapy 6:667-703), thalassemias, familial hypercholesterolemia, and hemophilia resulting from Factor VIII or Factor IX deficiencies (Crystal, R.G. (1995) Science 270:404-410; Verma, LM.
and Somia, N. (1997) Nature 389:239-242)), (ii) express a conditionally lethal gene product (e.g., in the case of cancers which result from unregulated cell proliferation), or (iii) express a protein which affords protection against intracellular parasites (e.g., against human retroviruses, such as human s immunodeficiency virus (HIV) (Baltimore, D. (1988) Nature 335:395-396;
Poeschla, E. et al. (1996) Proc. Natl. Acad. Sci. USA. 93:11395-11399), hepatitis B or C virus (HBV, HCV); fungal parasites, such as Candida albicans and Paracoccidioides brasiliensis; and protozoan parasites such as Plasmodium falciparum and Trypanosoma cruzi). In the case where a genetic deficiency in sptm expression or regulation causes disease, the expression of sptm from an appropriate population of ~ o transduced cells may alleviate the clinical manifestations caused by the genetic deficiency.
In a further embodiment of the invention, diseases or disorders caused by deficiencies in sptm are treated by constructing mammalian expression vectors comprising sptm and introducing these vectors by mechanical means into sptm-deficient cells. Mechanical transfer technologies for use with cells in vivo or ex vitro include (i) direct DNA microinjection into individual cells, (ii) ballistic gold 15 particle delivery, (iii) liposome-mediated transfection, (iv) receptor-mediated gene transfer, and (v) the use of DNA transposons (Morgan, R.A. and Anderson, W.F. (1993) Annu. Rev.
Biochem. 62:191-217;
Ivics, Z. (1997) Cell 91:501-510; Boulay, J-L, and Recipon, H. (1998) Curr.
Opin. Biotechnol. 9:445-450).
Expression vectors that may be effective for the expression of sptm include, but are not limited 2o to, the PCDNA 3.1, EPITAG, PRCCMV2, PREP, PVAX vectors (Invitxogen, Carlsbad CA), PCMV-SCRIPT, PCMV-TAG, PEGSH/PERV (Stratagene, La Jolla CA), and PTET-OFF, PTET-ON, PTRE2, PTRE2-LUC, PTK-HYG (Clontech, Palo Alto CA). The sptm of the invention may be expressed using (i) a constitutively active promoter, (e.g., from cytomegalovirus (CMV), Rous sarcoma virus (RSV), SV40 virus, thymidine kinase (TK), ox (3-actin genes), (ii) an inducible promoter 2s (e.g., the tetracycline-regulated promoter (Gossen, M. and Bujard, H.
(1992) Proc. Natl. Acad. Sci.
U.S.A. 89:5547-5551; Gossen, M. et al., (1995) Science 268:1766-1769; Rossi, F.M.V. and Blau, H.M. (1998) Curr. Opin. Biotechnol, 9:451-456), commercially available in the T-REX plasmid (Invitrogen); the ecdysone-inducible promoter (available in the plasmids PVGRXR and PIND;
Invitxogen); the FK506/rapamycin inducible promoter; or the RU486lmifepristone inducible promoter 3 0 (Rossi, F.M.V. and Blau, H.M. supra), or (iii) a tissue-specific promoter or the native promoter of the endogenous gene encoding SPTM from a normal individual.
Commercially available liposome transformation kits (e.g., the PERFECT LIPID
TRANSFECTION KIT, available from Invitrogen) allow one with ordinary skill in the art to deliver polynucleotides to target cells in culture and require minimal effort to optimize experimental 3 5 parameters. In the alternative, transformation is performed using the calcium phosphate method (Graham, F.L. and Eb, A.J. (1973) Virology 52:456-467), or by electroporation (Neumann, E. et al.
(1982) EMBO J. 1:841-845). The introduction of DNA to primary cells requires modification of these standardized mammalian transfection protocols.
In another embodiment of the invention, diseases or disorders caused by genetic defects with s respect to sptm expression are treated by constructing a retrovirus vector consisting of (i) sptm under the control of an independent promoter or the retrovirus long terminal repeat (LTR) promoter, (ii) appropriate RNA packaging signals, and (iii) a Rev-responsive element (RRE) along with additional retrovirus cis-acting RNA sequences and coding sequences required for efficient vector propagation.
Retrovirus vectors (e.g., PFB and PFBNEO) are commercially available (Stratagene) and are based on s o published data (Riviere, I. et al. (1995) Proc. Natl. Acad. Sci. U.S.A.
92:6733-6737), incorporated by reference herein. The vector is propagated in an appropriate vector producing cell line (VPCL) that expresses an envelope gene with a tropism for receptors on the target cells or a promiscuous envelope protein such as VSVg (Armentano, D. et al. (1987) J. Virol. 61:1647-1650;
Bender, M.A. et al. (1987) J. Virol. 61:1639-1646; Adam, M.A. and Miller, A.D. (1988) J. Virol. 62:3802-3806; Dull, T. et al.
15 (1998) J. Virol. 72:8463-8471; Zufferey, R, et al. (1998) J. Virol. 72:9873-9880). U.S. Patent Number 5,910,434 to Rigg ("Method for obtaining retrovirus packaging cell lines producing hightransducing efficiency retroviral supernatant") discloses a method for obtaining retrovirus packaging cell lines and is hereby incorporated by reference. Propagation of retrovirus vectors, transduction of a population of cells (e.g., CD4+ T-cells), and the return of transduced cells to a patient are procedures well known to 2 o persons skilled in the art of gene therapy and have been well documented (Ranga, U. et al. (1997) J.
Virol. 71:7020-7029; Bauer, G. et al. (1997) Blood 89:2259-2267; Bonyhadi, M.L. (1997) J. Virol.
71:4707-4716; Ranga, U. et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95:1201-1206; Su, L. (1997) Blood 89:2283-2290).
In the alternative, an adenovirus-based gene therapy delivery system is used to deliver sptm to 2 s cells which have one or more genetic abnormalities with respect to the expression of sptm. The construction and packaging of adenovirus-based vectors are well known to those with ordinary skill in the art. Replication defective adenovirus vectors have proven to be versatile for importing genes encoding immunoregulatory proteins into intact islets in the pancreas (Csete, M.E. et al. (1995) Transplantation 27:263-268). Potentially useful adenoviral vectors are described in U.S. Patent 3 o Number 5,707,618 to Armentano ("Adenovirus vectors for gene therapy"), hereby incorporated by reference. For adenoviral vectors, see also Antinozzi, P.A. et al. (1999) Annu. Rev. Nutr. 19:511-544 and Verma, LM. and Somia, N. (1997) Nature 18:389:239-242, both incorporated by reference herein.
In another alternative, a herpes-based, gene therapy delivery system is used to deliver sptm to target cells which have one or more genetic abnormalities with respect to the expression of sptm. The 3 s use of herpes simplex virus (HSV)-based vectors may be especially valuable for introducing sptm to cells of the central nervous system, for which HSV has a tropism. The construction and packaging of herpes-based vectors are well known to those with ordinary skill in the art. A
replication-competent herpes simplex virus (HSV) type 1-based vector has been used to deliver a reporter gene to the eyes of primates (Liu, X. et al. (1999) Exp. Eye Res.169:385-395). The construction of a HSV-1 virus vector s has also been disclosed in detail in U.S. Patent Number 5,804,413 to DeLuca ("Herpes simplex virus strains for gene transfer"), which is hereby incorporated by reference. U.S.
Patent Number 5,804,413 teaches the use of recombinant HSV d92 which consists of a genome containing at least one exogenous gene to be transferred to a cell under the contxol of the appropriate promoter for purposes including human gene therapy. Also taught by this patent are the construction and use of recombinant HSV
to strains deleted for ICP4, ICP27 and ICP22. For HSV vectors, see also Goins, W. F. et a1. 1999 J.
Virol. 73:519-532 and Xu, H. et al., (1994) Dev. Biol. 163:152-161, hereby incorporated by reference.
The manipulation of cloned herpesvirus sequences, the generation of recombinant virus following the transfection of multiple plasmids containing different segments of the large herpesvirus genomes, the growth and propagation of herpesvirus, and the infection of cells with herpesvirus are techniques well 15 known to those of ordinary skill in the art.
In another alternative, an alphavirus (positive, single-stranded RNA virus) vector is used to deliver sptm to target cells. The biology of the prototypic alphavirus, Semliki Forest Virus (SFV), has been studied extensively and gene transfer vectors have been based on the SFV
genome (Garoff, H. and Li, K-J. (1998) Curr. Opin. Biotech. 9:464-469). During alphavirus RNA
replication, a subgenomic z o RNA is generated that normally encodes the viral capsid proteins. This subgenomic RNA replicates to higher levels than the full-length genomic RNA, resulting in the overproduction of capsid proteins relative to the viral proteins with enzymatic activity (e.g., protease and polymerase). Similarly, inserting sptm into the alphavirus genome in place of the capsid-coding region results in the production of a large number of sptm RNAs and the synthesis of high levels of SPTM in vector transduced cells.
2 s While alphavirus infection is typically associated with cell lysis within a few days, the ability to establish a persistent infection in hamster normal kidney cells (BHK-21) with a variant of Sindbis virus (SIN) indicates that the lytic replication of alphaviruses can be altered to suit the needs of the gene therapy application (Dryga, S.A. et al. (1997) Virology 228:74-83). The wide host range of alphaviruses will allow the introduction of sptm into a variety of cell types.
The specific transduction 3 0 of a subset of cells in a population may require the sorting of cells prior to transduction. The methods of manipulating infectious cDNA clones of alphaviruses, performing alphavirus cDNA and RNA
transfections, and performing alphavirus infections, are well known to those with ordinary skill in the art.
3 5 Antibodies Anti-SPTM antibodies may be used to analyze protein expression levels. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, and Fab fragments. For descriptions of and protocols of antibody technologies, see, e.g., Pound J.D.
(1998) Immunochemical Protocols, Humana Press, Totowa, NJ.
s The amino acid sequence encoded by the sptm of the Sequence Listing may be analyzed by appropriate software (e.g., LASERGENE NAVIGATOR software, DNASTAR) to determine regions of high immunogenicity. The optimal sequences for immunization are selected from the C-terminus, the N-terminus, and those intervening, hydrophilic regions of the polypeptide which are likely to be exposed to the external environment when the polypeptide is in its natural conformation. Analysis used to select 1 o appropriate epitopes is also described by Ausubel (1997, suQra, Chapter 11.7). Peptides used for antibody induction do not need to have biological activity; however, they must be antigenic. Peptides used to induce specific antibodies may have an amino acid sequence consisting of at least five amino acids, preferably at least 10 amino acids, and most preferably at least 15 amino acids. A peptide which mimics an antigenic fragment of the natural polypeptide may be fused with another protein such as 15 keyhole limpet hemocyanin (KLH; Sigma, St. Louis MO) for antibody production. A peptide encompassing an antigenic region may be expressed from an sptm, synthesized as described above, or purified from human cells.
Procedures well known in the art may be used for the production of antibodies.
Various hosts including mice, goats, and rabbits, may be immunized by injection with a peptide. Depending on the 2 o host species, various adjuvants may be used to increase immunological response.
In one procedure, peptides about 15 residues in length may be synthesized using an ABI 431 A
peptide synthesizer (Applied Biosystems) using fmoc-chemistry and coupled to KLH (Sigma) by reaction with M-maleimidobenzoyl-N-hydroxysuccinimide ester (Ausubel, 1995, suQra). Rabbits are immunized with the peptide-KLH complex in complete Freund's adjuvant. The resulting antisera are 2 5 tested for antipeptide activity by binding the peptide to plastic, blocking with 1 % bovine serum albumin (BSA), reacting with rabbit antisera, washing, and reacting with radioiodinated goat anti-rabbit IgG.
Antisera with antipeptide activity are tested for anti-SPTM activity using protocols well known in the art, including ELISA, radioimmunoassay (RIA), and immunoblotting.
Tn another procedure, isolated and purified peptide may be used to immunize mice (about 100 3 0 ~ g of peptide) or rabbits (about 1 mg of peptide). Subsequently, the peptide is radioiodinated and used to screen the immunized animals' B-lymphocytes for production of antipeptide antibodies. Positive cells are then used to produce hybridomas using standard techniques. About 20 mg of peptide is sufficient for labeling and screening several thousand clones. Hybridomas of interest are detected by screening with radioiodinated peptide to identify those fusions producing peptide-specific monoclonal 3 s antibody. In a typical protocol, wells of a mufti-well plate (FAST, Becton-Dickinson, Palo Alto, CA) are coated with affinity-purified, specific rabbit-anti-mouse (or suitable anti-species IgG) antibodies at m~ml. The coated wells are blocked with 1 % BSA and washed and exposed to supernatants from hybridomas. After incubation, the wells are exposed to radiolabeled peptide at 1 mg/ml.
Clones producing antibodies bind a quantity of labeled peptide that is detectable above s background. Such clones are expanded and subjected to 2 cycles of cloning.
Cloned hybridomas are injected into pristane-treated mice to produce ascites, and monoclonal antibody is purified from the ascitic fluid by affinity chromatography on protein A (Amersham Pharmacia Biotech). Several procedures for the production of monoclonal antibodies, including in vitro production, are described in Pound su ra). Monoclonal antibodies with antipeptide activity are tested for anti-SPTM activity using s o protocols well known in the art, including ELISA, RIA, and immunoblotting.
Antibody fragments containing specific binding sites for an epitope may also be generated. For example, such fragments include, but are not limited to, the F(ab~2 fragments produced by pepsin digestion of the antibody molecule, and the Fab fragments generated by reducing the disulfide bridges of the F(ab~2 fragments. Alternatively, construction of Fab expression libraries in filamentous ~. s bacteriophage allows rapid and easy identification of monoclonal fragments with desired specificity (Pound, supra, Chaps. 45-47). Antibodies generated against polypeptide encoded by sptm can be used to purify and characterize full-length SPTM protein and its activity, binding partners, etc.
Assays Using Antibodies 2 o Anti-SPTM antibodies may be used in assays to quantify the amount of SPTM
found in a particular human cell. Such assays include methods utilizing the antibody and a label to detect expression level under normal or disease conditions. The peptides and antibodies of the invention may be used with or without modification or labeled by joining them, either covalently or noncovalently, with a reporter molecule.
2 s Protocols for detecting and measuring protein expression using either polyclonal or monoclonal antibodies are well known in the art. Examples include ELISA, RIA, and fluorescent activated cell sorting (FACS). Such immunoassays typically involve the formation of complexes between the SPTM
and its specific antibody and the measurement of such complexes. These and other assays are described in Pound su ra).
3 o Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.
The disclosures of all patents, applications, and publications mentioned above and below, 35 including U.S. Sex. No. 60/205,287, U.S. Ser. No. 60/205,324, U.S. Ser. No.
60/205,286, U.S. Ser.

No. 60/205,323, U.S. Ser. No. 60/185,215, U.S. Ser. No. 60/185,216, and U.S.
Ser. No. 60/205,232, are hereby expressly incorporated by reference.
EXAMPLES
s I. Construction of cDNA Libraries RNA was purchased from CLONTECH Laboratories, Inc. (Palo Alto CA) or isolated from various tissues. Some tissues were homogenized and lysed in guanidinium isothiocyanate, while others were homogenized and lysed in phenol or in a suitable mixture of denaturants, such as TRIZOL (Life Technologies), a monophasic solution of phenol and guanidine isothiocyanate.
The resulting lysates 1 o were centrifuged over CsCl cushions or extracted with chloroform. RNA was precipitated with either isopropanol or sodium acetate and ethanol, or by other routine methods.
Phenol extraction and precipitation of RNA were repeated as necessary to increase RNA
purity. In most cases, RNA was treated with DNase. For most libraries, poly(A+) RNA was isolated using oligo d(T)-coupled paramagnetic particles (Promega Corporation (Promega), Madison WI), 15 OLIGOTEX latex particles (QIAGEN, Inc. (QIAGEN), Valencia CA), or an OLIGOTEX mRNA
purification kit (QIAGEN). Alternatively, RNA was isolated directly from tissue lysates using other RNA isolation kits, e.g., the POLY(A)PURE mRNA purification kit (Ambion, Inc., Austin TX).
In some cases, Stratagene was provided with RNA and constructed the corresponding cDNA
libraries. Otherwise, cDNA was synthesized and cDNA libraries were constructed with the UNIZAP
2 o vector system (Stratagene Cloning Systems, Inc. (Stratagene), La Jolla CA) or SUPERSCRIPT
plasmid system (Life Technologies), using the recommended procedures or similar methods known in the art. (See, e.g., Ausubel, 1997, su ra, Chapters 5.1 through 6.6.) Reverse transcription was initiated using oligo d(T) or random primers. Synthetic oligonucleotide adapters were ligated to double stranded cDNA, and the cDNA was digested with the appropriate restriction enzyme or enzymes. For 2 s most libraries, the cDNA was size-selected (300-1000 bp) using SEPHACRYL S
1000, SEPHAROSE
CL2B, or SEPHAROSE CL4B column chromatography (Amersham Pharmacia Biotech) or preparative agarose gel electrophoresis. cDNAs were ligated into compatible restriction enzyme sites of the polylinker of a suitable plasmid, e.g., PBLUESCRIPT plasmid (Stratagene), PSPORT1 plasmid (Life Technologies), PCDNA2.1 plasmid (Invitrogen, Carlsbad CA), PBK-CMV
plasmid (Stratagene), 3 0 or pINCY (Incyte Genomics, Palo Alto CA), or derivatives thereof.
Recombinant plasmids were transformed into competent E, coli cells including XL1-Blue, XLl-BlueMRF, or SOLR from Stratagene or DHSa, DH10B, or ElectroMAX DH10B from Life Technologies.
II. Isolation of cDNA Clones Plasmids were recovered from host cells by in vivo excision using the UNIZAP
vector system (Stratagene) or by cell lysis. Plasmids were purified using at least one of the following: the Magic or WIZARD Minipreps DNA purification system (Promega); the AGTC Miniprep purification kit (Edge BioSystems, Gaithersburg MD); and the QIAWELL 8, QIAWELL 8 Plus, and QIAWELL 8 Ultra s plasmid purification systems or the R.E.A.L. PREP 96 plasmid purification kit (QIAGEN). Following precipitation, plasmids were resuspended in 0.1 ml of distilled water and stored, with or without lyophilization, at 4°C.
Alternatively, plasmid DNA was amplified from host cell lysates using direct link PCR in a high-throughput format. (Rao, V.B. (1994) Anal. Biochem. 216:1-14.) Host cell lysis and thermal ~ o cycling steps were carried out in a single reaction mixture. Samples were processed and stored in 384-well plates, and the concentration of amplified plasmid DNA was quantified fluorometrically using PICOGREEN dye (Molecular Probes, Inc. (Molecular Probes), Eugene OR) and a FLUOROSKAN II
fluorescence scanner (Labsystems Oy, Helsinki, Finland).
15 III. Sequencing and Analysis cDNA sequencing reactions were processed using standard methods or high-throughput instrumentation such as the ABI CATALYST 800 thermal cycler (Applied Biosystems) or the PTC-200 thermal cycler (MJ Research) in conjunction with the HYDRA microdispenser (Robbins Scientific Corp., Sunnyvale CA) or the MICROLAB 2200 liquid transfer system (Hamilton).
cDNA sequencing 2 o reactions were prepared using reagents provided by Amersham Pharmacia Biotech or supplied in ABI
sequencing kits such as the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems). Electrophoretic separation of cDNA sequencing reactions and detection of labeled polynucleotides were carried out using the MEGABACE 1000 DNA
sequencing system (Molecular Dynamics); the ABI PRISM 373 or 377 sequencing system (Applied Biosystems) in 2 s conjunction with standard ABI protocols and base calling software; or other sequence analysis systems known in the art. Reading frames within the cDNA sequences were identified using standard methods (reviewed in Ausubel, 1997, su ra, Chapter 7.7). Some of the cDNA sequences were selected for extension using the techniques disclosed in Example VIII.
3 o IV. Assembly and Analysis of Sequences Component sequences from chromatograms were subject to PHRED analysis and assigned a quality score. The sequences having at least a required quality score were subject to various pre-processing editing pathways to eliminate, e.g., low quality 3' ends, vector and linker sequences, polyA
tails, Alu repeats, mitochondrial and ribosomal sequences, bacterial contamination sequences, and 3 s sequences smaller than 50 base pairs. In particular, low-information sequences and repetitive elements (e.g., dinucleotide repeats, Alu repeats, etc.) were replaced by "n's", or masked, to prevent spurious matches.
Processed sequences were then subject to assembly procedures in which the sequences were assigned to gene bins (bins). Each sequence could only belong to one bin.
Sequences in each gene bin s were assembled to produce consensus sequences (templates). Subsequent new sequences were added to existing bins using BLASTn (v.1.4 Washl~ and CROSSMATCH. Candidate pairs were identified as all BLAST hits having a quality score greater than or equal to 150. Alignments of at least 82% local identity were accepted into the bin. The component sequences from each bin were assembled using a version of PHRAP. Bins with several overlapping component sequences were assembled using DEEP
1 o PHRAP. The orientation (sense or antisense) of each assembled template was determined based on the number and orientation of its component sequences. Template sequences as disclosed in the sequence listing correspond to sense strand sequences (the "forward" reading frames), to the best determination.
The complementary (antisense) strands are inherently disclosed herein. The component sequences which were used to assemble each template consensus sequence are listed in Table 2 along with their 15 positions along the template nucleotide sequences.
Bins were compared against each other and those having local similarity of at least 82% were combined and reassembled. Reassembled bins having templates of insufficient overlap (less than 95 %
local identity) were re-split. Assembled templates were also subject to analysis by STITCHERlEXON
MAPPER algorithms which analyze the probabilities of the presence of splice variants, alternatively 2 o spliced exons, splice junctions, differential expression of alternative spliced genes across tissue types or disease states, etc. These resulting bins were subject to several rounds of the above assembly procedures.
Once gene bins were generated based upon sequence alignments, bins were clone joined based upon clone information. If the 5' sequence of one clone was present in one bin and the 3' sequence from 2 s the same clone was present in a different bin, it was likely that the two bins actually belonged together in a single bin. The resulting combined bins underwent assembly procedures to regenerate the consensus sequences.
The final assembled templates were subsequently annotated using the following procedure.
Template sequences were analyzed using BLASTn (v2.0, NCBI) versus gbpri (GenBank version 120).
3 0 "Hits" were defined as an exact match having from 95 % local identity over 200 base pairs through 100% local identity over 100 base pairs, or a homolog match having an E-value, i.e. a probability score, of s 1 x 10-g. The hits were subject to frameshift FASTx versus GENPEPT
(GenBank version 120). (See Table 4). In this analysis, a homolog match was defined as having an E-value of s 1 x 10-8.
The assembly method used above was described in "System and Methods for Analyzing Biomolecular Sequences," U.S.S.N. 09/276,534, filed March 25, 1999, and the LIFESEQ Gold user manual (Incyte) both incorporated by reference herein.
Following assembly, template sequences were subjected to motif, BLAST, and functional analyses, and categorized in protein hierarchies using methods described in, e.g., "Database System Employing Protein Function Hierarchies for Viewing Biomolecular Sequence Data," U.S.S.N.
08/812,290, filed March 6, 1997; "Relational Database for Storing Biomolecule Information,"
U.S.S.N. 081947,845, filed October 9, 1997; "Project-Based Full-Length Biomolecular Sequence Database," U.S.S.N. 08/811,758, filed March 6, 1997; and "Relational Database and System for Storing Information Relating to Biomolecular Sequences," U.S.S.N. 09/034,807, filed March 4, 1998, s o all of which are incorporated by reference herein.
The template sequences were further analyzed by translating each template in all three forward reading frames and searching each translation against the Pfam database of hidden Markov model-based protein families and domains using the HMMER software package (available to the public from Washington University School of Medicine, St. Louis MO). (See also World Wide Web site http://pfam.wustl.edu/ for detailed descriptions of Pfam protein domains and families.) Additionally, the template sequences were translated in alI three forward reading frames, and each translation was searched against hidden Markov models for signal peptides using the HMMER
software package. Construction of hidden Markov models and their usage in sequence analysis has been described. (See, for example, Eddy, S.R. (1996) Curr. Opin. Str. Biol.

6:361-365.) Only those 2 o signal peptide hits with a cutoff score of 11 bits or greater are reported. A cutoff score of 11 bits or greater corresponds to at least about 91-94% true-positives in signal peptide prediction. Template sequences were also translated in all three forward reading frames, and each translation was searched against TMAP, a program that uses weight matrices to delineate transmembrane segments on protein sequences and determine orientation, with respect to the cell cytosol (Persson, B, and Argos, P. (1994) 2 5 J. Mol. Biol. 237:182-192, and Persson, B. and Argos, P. (1996) Protein Sci. 5:363-371.) Regions of templates which, when translated, contain similarity to signal peptide or transmembrane consensus sequences are reported in Table 1.
Template sequences are further analyzed using the bioinformatics tools listed in Table 4, or using sequence analysis software known in the art such as MACDNASIS PRO
software (Hitachi 3 o Software Engineering, South San Francisco CA) and LASERGENE software (DNASTAR). Template sequences may be further queried against public databases such as the GenBank rodent, mammalian, vertebrate, prokaryote, and eukaryote databases.
V. Analysis of Polynucleotide Expression Northern analysis is a laboratory technique used to detect the presence of a transcript of a gene and involves the hybridization of a labeled nucleotide sequence to ~a membrane on which RNAs from a particular cell type or tissue have been bound. (See, e.g., Sambrook, supra, ch. 7; Ausubel, 1995, supra, ch. 4 and 16.) . Analogous computer techniques applying BLAST were used to search for identical or related molecules in cDNA databases such as GenBank or LIFESEQ (Incyte Genomics). This analysis is much faster than multiple membrane-based hybridizations. In addition, the sensitivity, of the computer search can be modified to determine whether any particular match is categorized as exact or similar.
The basis of the search is the product score, which is defined as:
BLAST Score x Percent Identity 5 x minimum {length(Seq. 1), length(Seq. 2)}
The product score takes into account both the degree of similarity between two sequences and the length 1 s of the sequence match. The product score is a normalized value between 0 and 100, and is calculated as follows: the BLAST score is multiplied by the percent nucleotide identity and the product is divided by (5 times the length of the shorter of the two sequences). The BLAST score is calculated by assigning a score of +5 for every base that matches in a high-scoring segment pair (HSP), and -4 for every mismatch. Two sequences may share more than one HSP (separated by gaps).
If there is more 2 o than one HSP, then the pair with the highest BLAST score is used to calculate the product score. The product score represents a balance between fractional overlap and quality in a BLAST alignment. For example, a product score of 100 is produced only for 100% identity over the entire length of the shorter of the two sequences being compared. A product score of 70 is produced either by 100% identity and 70% overlap at one end, or by 88% identity and 100% overlap at the other. A
product score of 50 is 2 s produced either by 100% identity and 50% overlap at one end, or 79%
identity and 100% overlap.
Alternatively, polynucleotide sequences encoding SPTM are analyzed with respect to the tissue sources from which they were derived. Polynucleotide sequences encoding SPTM
were assembled, at least in part, with overlapping Incyte cDNA sequences. Each cDNA sequence is derived from a cDNA
library constructed from a human tissue. Each human tissue is classified into one of the following 3 0 organ/tissue categories: cardiovascular system; connective tissue;
digestive system; embryonic structures; endocrine system; exocrine glands; genitalia, female; genitalia, male; germ cells; heroic and immune system; liver; musculoskeletal system; nervous system; pancreas;
respiratory system; sense organs; skin; stomatognathic system; unclassified/mixed; or urinary tract. The number of libraries in each category for each polynucleotide sequence encoding SPTM is counted and divided by the total 3 s number of libraries across all categories for each polynucleotide sequence encoding SPTM. Similarly, each human tissue is classified into one of the following disease/condition categories: cancer, cell line, developmental, inflammation, neurological, trauma, cardiovascular, pooled, and other, and the number of libraries in each category for each polynucleotide sequence encoding SPTM
is counted and divided by the total number of libraries across all categories for each polynucleotide sequence encoding SPTM.
s The resulting percentages reflect the tissue-specific and disease-specific expression of cDNA encoding SPTM. Percentage values of tissue-specific expression are reported in Table 3.
cDNA sequences and cDNA library/tissue information are found in the LIFESEQ GOLD database (Incyte Genomics, Palo Alto CA).
VI. Tissue Distribution Profiling s o A tissue distribution profile is determined for each template by compiling the cDNA library tissue classifications of its component cDNA sequences. Each component sequence, is derived from a cDNA library constructed from a human tissue. Each human tissue is classified into one of the following categories: cardiovascular system; connective tissue; digestive system; embryonic structures;
endocrine system; exocrine glands; genitalia, female; genitalia, male; germ cells; heroic and immune is system; liver; musculoskeletal system; nervous system; pancreas;
respiratory system; sense organs;
skin; stomatognathic system; unclassified/mixed; or urinary tract. Template sequences, component sequences, and cDNA library/tissue information are found in the LIFESEQ GOLD
database (Incyte Genomics, Palo Alto CA).
Table 3 shows the tissue distribution profile for the templates of the invention. For each 2 o template, the three most frequently observed tissue categories are shown in column 2, along with the percentage of component sequences belonging to each category. Only tissue categories with - percentage values of >_ 10% are shown. A tissue distribution of "widely distributed" in column 2 indicates percentage values of <10% in all tissue categories.
2 s VII. Transcript Image Analysis Transcript images are generated as described in Seilhamer et al., "Comparative Gene Transcript Analysis," U.S. Patent Number 5,840,484, incorporated herein by reference.
VTII. Extension of Polynucleotide Sequences and Isolation of a Full-length cDNA
3 o Oligonucleotide primers designed using an sptm of the Sequence Listing are used to extend the nucleic acid sequence. One primer is synthesized to initiate 5' extension of the template, and the other primer, to initiate 3' extemion of the template. The initial primers may be designed using OLIGO 4.06 software (National Biosciences, Inc. (National Biosciences), Plymouth MN), or another appropriate program, to be about 22 to 30 nucleotides in length, to have a GC content of about 50% or more, and to 3 s anneal to the target sequence at temperatures of about 68 °C to about 72°C. Any stretch of nucleotides which would result in hairpin structures and primer-primer dimerizations are avoided. Selected human cDNA libraries are used to extend the sequence. If more than one extension is necessary or desired, additional or nested sets of primers are designed.
High fidelity amplification is obtained by PCR using methods well known in the art. PCR is performed in 96-well plates using the PTC-200 thermal cycler (MJ Research).
The reaction mix contains DNA template, 200 nmol of each primer, reaction buffer containing Mg2+, (NH4)ZS O4, and 13-mercaptoethanol, Taq DNA polymerase (Amersham Pharmacia Biotech), ELONGASE
enzyme (Life Technologies), and Pfu DNA polymerase (Stratagene), with the following parameters for pximer pair PCI A and PCI B: Step 1: 94°C, 3 min; Step 2: 94°C, 15 sec; Step 3: 60°C, 1 min; Step 4: 68 °C, 2 1o min; Step 5: Steps 2, 3, and 4 repeated 20 times; Step 6: 68°C, 5 min; Step 7: storage at 4°C. In the alternative, the parameters for primer pair T7 and SK+ are as follows: Step 1:
94 °C, 3 min; Step 2:
94°C, IS sec; Step 3: 57°C, I min; Step 4: 68°C, 2 min;
Step S: Steps 2, 3, and 4 repeated 20 times;
Step 6: 68 ° C, 5 min; Step 7: storage at 4 ° C.
The concentration of DNA in each well is determined by dispensing 100 ~1 PICOGREEN
quantitation reagent (0.25% (v/v); Molecular Probes) dissolved in 1X Tris-EDTA
(TE) and 0.5 ~1 of undiluted PCR product into each well of an opaque fluorimeter plate (Corning Incorporated (Corning), Corning NY), allowing the DNA to bind to the reagent. The plate is scanned in a FLUOROSKAN II
(Labsystems Oy) to measure the fluorescence of the sample and to quantify the concentration of DNA.
A 5 p1 to 10 p1 aliquot of the reaction mixture is analyzed by electrophoresis on a 1 % agarose mini-gel 2 o to determine which reactions are successful in extending the sequence.
The extended nucleotides are desalted and concentrated, transferred to 384-well plates, digested with CviJI cholera virus endonuclease (Molecular Biology Research, Madison WI), and sonicated or sheared prior to religation into pUC 18 vector (Amersham Pharmacia Biotech). For shotgun sequencing, the digested nucleotides are separated on low concentration (0.6 to 0.8%) agarose 2 5 gels, fragments are excised, and agar digested with AGAR ACE (Promega).
Extended clones are relegated using T4 ligase (New England Biolabs, Inc., Beverly MA) into pUC 18 vector (Amersham Pharmacia Biotech), treated with Pfu DNA polymerase (Stratagene) to fill-in restriction site overhangs, and transfected into competent E. coli cells. Transformed cells are selected on antibiotic-containing media, individual colonies are picked and cultured overnight at 37 ° C
in 384-well plates in LB/2x 3 o carbenicillin liquid media.
The cells are lysed, and DNA is amplified by PCR using Taq DNA polymerase (Amersham Phaxmacia Biotech) and Pfu DNA polymerase (Stratagene) with the following parameters: Step 1:
94 ° C, 3 min; Step 2: 94 ° C, 15 sec; Step 3 : 60 ° C, 1 min; Step 4: 72 ° C, 2 min; Step 5 : steps 2, 3, and 4 repeated 29 times; Step 6: 72°C, 5 min; Step 7: stoxage at 4°C.
DNA is quantified by PICOGREEN
3 5 reagent (Molecular Probes) as described above. Samples with low DNA
recoveries are reamplified using the same conditions as described above. Samples are diluted with 20%
dimethysulfoxide (1:2, v/v), and sequenced using DYENAMIC energy transfer sequencing primers and the DYENAMIC
DIRECT kit (Amersham Pharmacia Biotech) or the ABI PRISM BIGDYE Terminator cycle sequencing ready reaction kit (Applied Biosystems).
In like manner, the sptm is used to obtain regulatory sequences (promoters, introns, and enhancers) using the procedure above, oligonucleotides designed for such extension, and an appropriate genomic library.
IX. Labeling of Probes and Southern Hybridization Analyses 1 o Hybridization probes derived from the sptm of the Sequence Listing are employed for screening cDNAs, mRNAs, or genomic DNA. The labeling of probe nucleotides between 100 and 1000 nucleotides in length is specifically described, but essentially the same procedure may be used with larger cDNA fragments. Probe sequences are labeled at room temperature for 30 minutes using a T4 polynucleotide kinase, Ysap-ATP, and O.SX One-Phor-Atl Plus (Amersham Pharmacia Biotech) 1 s buffer and purified using a ProbeQuant G-SO Microcolumn (Amersham Pharmacia Biotech). The probe mixture is diluted to 10' dpm/~~ml hybridization buffer and used in a typical membrane-based hybridization analysis.
The DNA is digested with a restriction endonuclease such as Eco RV and is electrophor esed through a 0.7% agarose gel. The DNA fragments are transferred from the agarose to nylon membrane 2 0 (NYTRAN Plus Schleicher & Schuell, Inc., Keene NH) using procedures specified by the manufacturer of the membrane. Prehybridization is carried out for three or more hours at 68 ° C, and hybridization is carried out overnight at 68 °C. To remove non-specific signals, blots are sequentially washed at room temperature under increasingly stringent conditions, up to 0.
lx saline sodium citrate (SSC) and 0.5% sodium dodecyl sulfate. After the blots are placed in a PHOSPHORIMAGER cassette 2 5 (Molecular Dynamics) or are exposed to autoradiography film, hybridization patterns of standard and experimental lanes are compared. Essentially the same procedure is employed when screening RNA.
X. Chromosome Mapping of sptm The cDNA sequences which were used to assemble SEQ ID NO:1-79 are compared with 3 o sequences from the Incyte LIFESEQ database and public domain databases using BLAST and other implementations of the Smith-Waterman algorithm. Sequences from these databases that match SEQ
ID NO:1-79 are assembled into clusters of contiguous and overlapping sequences using assembly algorithms such as PHRAP (Table 4). Radiation hybrid and genetic mapping data available from public resources such as the Stanford Human Genome Center (SHGC), Whitehead Institute for Genome 3 5 Research (WIGR), and Genethon are used to determine if any of the clustered sequences have been previously mapped. Inclusion of a mapped sequence in a cluster will result in the assignment of all sequences of that cluster, including its particular SEQ ID NO:, to that map location. The genetic map locations of SEQ ID NO:l-79 are described as ranges, or intervals, of human chromosomes. The map position of an interval, in centiMorgans, is measured relative to the terminus of the chromosome's p-arm. (The centiMorgan (cM) is a unit of measurement based on recombination frequencies between chromosomal markers. On average, 1 cM is roughly equivalent to 1 megabase (Mb) of DNA in humans, although this can vary widely due to hot and cold spots of recombination.) The cM distances are based on genetic markers mapped by Genethon which provide boundaries for radiation hybrid markers whose sequences were included in each of the clusters.
XI. Microarray Analysis Probe Preparation from Tissue or Cell Samples Total RNA is isolated from tissue samples using the guanidinium thiocyanate method and polyA+ RNA is purified using the oligo (dT) cellulose method. Each polyA+ RNA
sample is reverse transcribed using MMLV reverse-transcriptase, 0.05 pgl~l oligo-dT primer (2lmer), 1X first strand buffer, 0.03 units/~1 RNase inhibitor, 500 ~M dATP, 500 ~M dGTP, 500 ~M dTTP, 40 ~M dCTP, 40 ~M dCTP-Cy3 (BDS) or dCTP-Cy5 (Amersham Pharmacia Biotech). The reverse transcription reaction is performed in a 25 ml volume containing 200 ng polyA+ RNA with GEMBRIGHT kits (Incyte). Specific control polyA+ RNAs are synthesized by in vitro transcription from non-coding yeast 2 o genomic DNA (W. Lei, unpublished). As quantitative controls, the control mRNAs at 0.002 ng, 0.02 ng, 0.2 ng, and 2 ng are diluted into reverse transcription reaction at ratios of 1:100,000, 1:10,000, 1:1000, 1:100 (w/w) to sample mRNA respectively. The control mRNAs are diluted into reverse transcription reaction at ratios of 1:3, 3:1, 1:10, 10:1, 1:25, 25:1 (w/w) to sample mRNA differential expression patterns. After incubation at 37° C for 2 hr, each reaction sample (one with Cy3 and another 2 s with Cy5 labeling) is treated with 2.5 ml of O.SM sodium hydroxide and incubated for 20 minutes at 85° C to the stop the reaction and degrade the RNA. Probes are purified using two successive CHROMA SPIN 30 gel filtration spin columns (CLONTECH Laboratories, Inc.
(CLONTECH), Palo Alto CA) and after combining, both reaction samples are ethanol precipitated using 1 ml of glycogen (1 mg/ml), 60 ml sodium acetate, and 300 ml of 100% ethanol. The probe is then dried to completion 30 ~ using a SpeedVAC (Savant Instruments Inc., Holbrook NY) and resuspended in 14 ~1 SX SSC/0.2%
SDS.
Microarray Preparation Sequences of the present invention are used to generate array elements. Each array element is 3 s amplified from bacterial cells containing vectors with cloned cDNA
inserts. PCR amplification uses primers complementary to the vector sequences flanking the cDNA insert. Array elements are amplified in thirty cycles of PCR from an initial quantity of 1-2 ng to a final quantity greater than 5 fig.
Amplified array elements are then purified using SEPHACRYL-400 (Amersham Pharmacia Biotech).
Purified array elements are immobilized on polymer-coated glass slides. Glass microscope s slides (Corning) are cleaned by ultrasound in 0.1 % SDS and acetone, with extensive distilled water washes between and after treatments. Glass slides are etched in 4%
hydrofluoric acid (VWR Scientific Products Corporation (VWR), West Chester, PA), washed extensively in distilled water, and coated with 0.05 % aminopropyl silane (Sigma) in 95 % ethanol. Coated slides are cured in a 110°C oven.
Array elements are applied to the coated glass substrate using a procedure described in US
to Patent No. 5,807,522, incorporated herein by reference. 1 ~I of the array element DNA, at an average concentration of 100 ng/~1, is loaded into the open capillary printing element by a high-speed robotic apparatus. The apparatus then deposits about 5 n1 of array element sample per slide.
Microarrays are UV-crosslinked using a STRATALINI~ER UV-crosslinker (Stratagene).
Microarrays are washed at room temperature once in 0.2% SDS and three times in distilled water.
15 Non-specific binding sites are blocked by incubation of microarrays in 0.2%
casein in phosphate buffered saline (PBS) (Tropix, Inc., Bedford, MA) for 30 minutes at 60°
C followed by washes in 0.2%
SDS and distilled water as before.
Hybridization 2 o Hybridization reactions contain 9 ~ 1 of probe mixture consisting of 0.2 ~
g each of Cy3 and Cy5 labeled cDNA synthesis products in SX SSC, 0.2% SDS hybridization buffer.
The probe mixture is heated to 65° C for 5 minutes and is aliquoted onto the microarray surface and covered with an 1.8 cm2 coverslip. The arrays are transferred to a waterproof chamber having a cavity just slightly larger than a microscope slide. The chamber is kept at 100% humidity internally by the addition of 140 ~1 of 2 s Sx SSC in a corner of the chamber. The chamber containing the arrays is incubated for about 6.5 hours at 60° C. The arrays are washed for 10 min at 45° C in a first wash buffer (1X SSC, 0.1 % SDS), three times for 10 minutes each at 45° C in a second wash buffer (0.1X
SSC), and dried.
Detection 3 o Reporter-labeled hybridization complexes are detected with a microscope equipped with an Innova 70 mixed gas 10 W laser (Coherent, Inc., Santa Clara CA) capable of generating spectral lines at 488 nm for excitation of Cy3 and at 632 nm for excitation of CyS. The excitation laser light is focused on the array using a 20X microscope objective (Nikon, Inc., Melville NY). The slide containing the array is placed on a computer-controlled X-Y stage on the microscope and raster-scanned past the objective. The 1.8 cm x 1.8 cm array used in the present example is scanned with a resolution of 20 micrometers.
In two separate scans, a mixed gas multiline laser excites the two fluorophores sequentially.
Emitted light is split, based on wavelength, into two photomultiplier tube detectors (PMT 81477, s Hamamatsu Photonics Systems, Bridgewater NJ) corresponding to the two fluorophores. Appropriate filters positioned between the array and the photomultiplier tubes are used to filter the signals. The emission maxima of the fluorophores used are 565 nm for Cy3 and 650 nm for CyS. Each array is typically scanned twice, one scan per fluorophore using the appropriate filters at the laser source, although the apparatus is capable of recording the spectra from both fluorophores simultaneously.
1 o The sensitivity of the scans is typically calibrated using the signal intensity generated by a cDNA control species added to the probe mix at a known concentration. A
specific location on the array contains a complementary DNA sequence, allowing the intensity of the signal at that location to be correlated with a weight ratio of hybridizing species of 1:100,000. When two probes from different sources (e.g., representing test and control cells), each labeled with a different fluorophore, are 15 hybridized to a single array for the purpose of identifying genes that are differentially expressed, the calibration is done by labeling samples of the calibrating cDNA with the two fluorophores and adding identical amounts of each to the hybridization mixture.
The output of the photomultiplier tube is digitized using a 12-bit RTI-835H
analog-to-digital (A/D) conversion board (Analog Devices, Inc., Norwood, MA) installed in an IBM-compatible PC
2 o computer. The digitized data are displayed as an image where the signal intensity is mapped using a linear 20-color transformation to a pseudocolor scale ranging from blue (low signal) to red (high signal). The data is also analyzed quantitatively. Where two different fluorophores are excited and measured simultaneously, the data are first corrected for optical crosstalk (due to overlapping emission spectra) between the fluorophores using each fluorophore's emission spectrum.
2 s A grid is superimposed over the fluorescence signal image such that the signal from each spot is centered in each element of the grid. The fluorescence signal within each element is then integrated to obtain a numerical value corresponding to the average intensity of the signal.
The software used for signal analysis is the GEMTOOLS gene expression analysis program (Incyte).
3 o XII. Complementary Nucleic Acids Sequences complementary to the sptm are used to detect, decrease, or inhibit expression of the naturally occurring nucleotide. The use of oligonucleotides comprising from about 15 to 30 base pairs is typical in the art. However, smaller or larger sequence fragments can also be used. Appropriate oligonucleotides are designed from the sptm using OLIGO 4.06 software (National Biosciences) or 3 s other appropriate programs and are synthesized using methods standard in the art or ordered from a commercial supplier. To inhibit transcription, a complementary oligonucleotide is designed from the most unique 5' sequence and used to prevent transcription factor binding to the promoter sequence. To inhibit translation, a complementary oligonucleotide is designed to prevent ribosomal binding and processing of the transcript.
XIII. Expression of SPTM
Expression and purification of SPTM is accomplished using bacterial or vinzs-based expression systems. For expression of SPTM in bacteria, cDNA is subcloned into an appropriate vector containing an antibiotic resistance gene and an inducible promoter that directs high levels of 1 o cDNA transcription. Examples of such promoters include, but are not limited to, the trp-lac (tic) hybrid promoter and the TS or T7 bacteriophage promoter in conjunction with the lac operator regulatory element. Recombinant vectors are transformed into suitable bacterial hosts, e.g., BL21 (DE3). Antibiotic resistant bacteria express SPTM upon induction with isopropyl beta-D-thiogalactopyranoside (IPTG). Expression of SPTM in eukaryotic cells is achieved by infecting insect s s or mammalian cell lines with recombinant Autog-raphica californica nuclear polyhedrosis virus (AcMNPV), commonly known as baculovirus. The nonessential polyhedrin gene of baculovirus is replaced with cDNA encoding SPTM by either homologous recombination or bacterial-mediated transposition involving transfer plasmid intermediates. Viral infectivity is maintained and the strong polyhedrin promoter drives high levels of cDNA transcription. Recombinant baculovirus is used to z o infect Spodoptera fru~iperda (Sf9) insect cells in most cases, or human hepatocytes, in some cases.
Infection of the latter requires additional genetic modifications to baculovirus. (See e.g., Engelhard, supra; and Sandig, supra.) In most expression systems, SPTM is synthesized as a fusion protein with, e.g., glutathione S-transferase (GST) or a peptide epitope tag, such as FLAG or 6-His, permitting rapid, single-step, 2 s affinity-based purification of recombinant fusion protein from crude cell lysates. GST, a 26-kilodalton enzyme from Schistosoma iaponicum, enables the purification of fusion proteins on immobilized glutathione under conditions that maintain protein activity and antigenicity (Amersham Pharmacia Biotech). Following purification, the GST moiety can be proteolytically cleaved from SPTM at specifically engineered sites. FLAG, an 8-amino acid peptide, enables immunoaffinity purification 3 o using commercially available monoclonal and polyclonal anti-FLAG
antibodies (Eastman Kodak Company, Rochester N~. 6-His, a stretch of six consecutive histidine residues, enables purification on metal-chelate resins (QIAGEN). Methods for protein expression and purification are discussed in Ausubel (1995, supra, Chapters 10 and 16). Purified SPTM obtained by these methods can be used directly in the following activity assay.

XIV. Demonstration of SPTM Activity An assay for SPTM activity measures the expression of SPTM on the cell surface. cDNA
encoding SPTM is subcloned into an appropriate mammalian expression vector suitable for high levels of cDNA expression. The resulting construct is transfected into a nonhuman cell line such as NIH3T3.
s Cell surface proteins are labeled with biotin using methods known in the art. Immunoprecipitations are performed using SPTM-specific antibodies, and immunoprecipitated samples are analyzed using SDS-PAGE and immunoblotting techniques. The ratio of labeled immunoprecipitant to unlabeled immunoprecipitant is proportional to the amount of SPTM expressed on the cell surface.
Alternatively, an assay for SPTM activity measures the amount of SPTM in secretory, 1 o membrane-bound organelles. Transfected cells as described above are harvested and lysed. The lysate is fractionated using methods known to those of skill in the art, for example, sucrose gradient ultracentrifugation. Such methods allow the isolation of subcellular components such as the Golgi apparatus, ER, small membrane-bound vesicles, and other secretory organelles.
Immunoprecipitations from fractionated and total cell lysates are performed using SPTM-specific antibodies, and 1 s immunoprecipitated samples are analyzed using SDS-PAGE arid immunoblotting techniques. The concentration of SPTM in secretory organelles relative to SPTM in total cell lysate is proportional to the amount of SPTM in txansit through the secretory pathway.
XV. Functional Assays 2 o SPTM function is assessed by expressing sptm at physiologically elevated levels in mammalian cell culture systems. cDNA is subcloned into a mammalian expression vector containing a strong promoter that drives high levels of cDNA expression. Vectors of choice include pCMV SPORT (Life Technologies) and pCR3.1 (Invitrogen Corporation, Carlsbad CA), both of which contain the cytomegalovirus promoter. 5-10 ~ g of recombinant vector are transiently transfected into a human cell 2 s line, preferably of endothelial or hematopoietic origin, using either liposome formulations or electroporation. 1-2 ~g of an additional plasmid containing sequences encoding a marker protein are co-transfected.
Expression of a marker protein provides a means to distinguish transfected cells from nontransfected cells and is a reliable predictor of cDNA expression from the recombinant vector.
a o Marker proteins of choice include, e.g., Green Fluorescent Protein (GFP;
CLONTECH), CD64, or a CD64-GFP fusion protein. Flow cytometry (FCM), an automated laser optics-based technique, is used to identify transfected cells expressing GFP or CD64-GFP and to evaluate the apoptotic state of the cells and other cellular properties.
FCM detects and quantiFies the uptake of fluorescent molecules that diagnose events preceding 3 s or coincident with cell death. These events include changes in nuclear DNA
content as measured by staining of DNA with propidium iodide; changes in cell size and granularity as measured by forward light scatter and 90 degree side light scatter; down-regulation of DNA
synthesis as measured by decrease in bromodeoxyuridine uptake; alterations in expression of cell surface and intracellular proteins as measured by reactivity with specific antibodies; and alterations in plasma membrane s composition as measured by the binding of fluorescein-conjugated Annexin V
protein to the cell surface. Methods in flow cytometry axe discussed in Ormerod, M. G. (1994) Flow Cytometry, Oxford, New York NY.
The influence of SPTM on gene expression can be assessed using highly purified populations of cells transfected with sequences encoding SPTM and either CD64 or CD64-GFP.
CD64 and CD64-~. o GFP are expressed on the surface of txansfected cells and bind to conserved regions of human immunoglobulin G (IgG). Transfected cells are efficiently separated from nontransfected cells using magnetic beads coated with either human IgG or antibody against CD64 (DYNAL, Inc., Lake Success NY). mRNA can be purified from the cells using methods well known by those of skill in the art.
Expression of mRNA encoding SPTM and other genes of interest can be analyzed by northern analysis z s or microarray techniques.
XVI. Production of Antibodies SPTM substantially purified using polyacrylamide gel electrophoresis (PAGE;
see, e.g., Harrington, M.G. (1990) Methods Enzymol. 182:488-495), or other purification techniques, is used to immunize rabbits and to produce antibodies using standard protocols.
2 o Alternatively, the SPTM amino acid sequence is analyzed using LASERGENE
software (DNASTAR) to determine regions of high immunogenicity, and a corresponding peptide is synthesized and used to raise antibodies by means known to those of skill in the art.
Methods for selection of appropriate epitopes, such as those near the C-terminus or in hydrophilic regions are well described in the art. (See, e.g., Ausubel, 1995, supra, Chapter 11.) 2 s Typically, peptides 15 residues in length axe synthesized using an ABI
431A peptide synthesizer (Applied Biosystems) using fmoc-chemistry and coupled to KLH
(Sigma) by reaction with N-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) to increase immunogenicity. (See, e.g., Ausubel, supra.) Rabbits axe immunized with the peptide-I~LH complex in complete Freund's adjuvant. Resulting antisera are tested for antipeptide activity by, for example, binding the peptide to 3 o plastic, blocking with 1 % BSA, reacting with rabbit antisera, washing, and reacting with radio-iodinated goat anti-rabbit IgG. Antisera with antipeptide activity are tested for anti-SPTM activity using protocols well known in the art, including ELISA, RIA, and immunoblotting.
XVII. Purification of Naturally Occurring SPTM Using Specific Antibodies Naturally occurring or recombinant SPTM is substantially purified by immunoaffinity chromatography using antibodies specific for SPTM. An immunoaffinity column is constructed by covalently coupling anti-SPTM antibody to an activated chromatographic resin, such as CNBr-activated SEPHAROSE (Amersham Pharmacia Biotech). After the coupling, the resin is blocked and washed according to the manufacturer's instructions.
Media containing SPTM are passed over the immunoaffinity column, and the column is washed under conditions that allow the preferential absorbance of SPTM (e.g., high ionic strength buffers in the presence of detergent). The column is eluted under conditions that disrupt antibody/SPTM binding (e.g., a buffer of pH 2 to pH 3, or a high concentration of a chaotrope, such as urea or thiocyanate ion), s o and SPTM is collected.
XVIII. Identification of Molecules Which Interact with SPTM
SPTM, or biologically active fragments thereof, are labeled with lzsl Bolton-Hunter reagent.
(See, e.g., Bolton, A.E, and W.M. Hunter (1973) Biochem. J. 133:529-539.) Candidate molecules previously arrayed in the wells of a multi-well plate are incubated with the labeled SPTM, washed, and any wells with labeled SPTM complex are assayed. Data obtained using different concentrations of SPTM are used to calculate values for the number, affinity, and association of SPTM with the candidate molecules.
Alternatively, molecules interacting with SPTM are analyzed using the yeast two-hybrid system 2 o as described in Fields, S. and O. Song (1989) Nature 340:245-246, or using commercially available kits based on the two-hybrid system, such as the MATCHMAKER system (CLONTECH).
SPTM may also be used in the PATHCALLING process (CuraGen Corp., New Haven CT) which employs the yeast two-hybrid system in a high-throughput manner to determine all interactions between the proteins encoded by two large libraries of genes (Nandabalan, K.
et al. (2000) U.S. Patent No.6,057,101).
All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention.
3 o Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should riot be unduly limited to such specific embodiments.
Indeed, various modifications of the above-described modes for carrying out the invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims.

Table 1 SEQ
ID Template - Domain N0:ID StartStop Frame Type Topology 1 LG:223939.1:2000FEB18202 288 forward2 TM N in 2 LG:397140.1:2000FEB18508 588 forward1 TM

2 LG:397140.1:2000FEB18236 319 forward2 TM N out 2 LG:397140.1:2000FEB18377 463 forward2 TM N out 2 LG:397240.1:2000FEB18288 374 forward3 TM

2 LG:397140.1:2000FEB18480 566 forward3 TM

3 LG:1094205.1:2000FEB18826 912 forward1 TM N in 3 LG:1094205.1:2000FEB18867 953 forward3 TM N out 4 LG:482361.5:2000FEB18215 201 forward1 TM N out 4 LG:481361.5:2000FEB18295 354 forward1 TM N out 4 LG:481361.5:2000FEB18373 459 forward1 TM N out 4 LG:481361.5:2000FEB18101 187 forward2 TM N out 4 LG:482361.5:2000FEB18369 443 forward3 TM N out LG:981170.1:2000FEB1810 78 forward1 TM N out 5 LG:981170.1:2000FEB18598 648 forward1 TM N out 5 LG:981170.1:2000FEB18790 876 forward1 TM N out 5 LG:982170.1:2000FEB181057 2143 forward1 TM N out 5 LG:981170.1:2000FEB181372 1458 forward1 TM N out 5 LG:981170.1:2000FEB181678 1764 forward1 TM N out 5 LG:981170.1:2000FEB181885 1959 forward1 TM N out 5 LG:981170.1:2000FEB1811 82 forward2 TM N out 5 LG:981170.1:2000FEB18731 817 forward2 TM N out 5 LG:981170.1:2000FEB181025 1105 forward2 TM N out 5 LG:981170.1:2000FEB181364 1450 forward2 TM N out 5 LG:981170.1:2000FEB181643 1696 forward2 TM N out 5 LG:981170.1:2000FEB181895 1954 forward2 TM N out 5 LG:981170.1:2000FEB1824 110 forward3 TM N out 5 LG:981170.2:2000FEB18843 899 forward3 TM N out 5 LG:981170.1:2000FEB281068 1136 forward3 TM N out 5 LG:981170.1:2000FEB181599 1655 forward3 TM N out 5 LG:981170.1:2000FEB181707 1793 forward3 TM N out 5 LG:981170.1:2000FEB181875 1961 forward3 TM N out 6 LI:197623.1:2000FEB01140 226 forward2 TM N out 6 LI:197613.1:2000FEB01269 355 forward2 TM N out 7 LI:902682.1:2000FEB01225 311 forward3 TM N out 8 LI:212029.1:2000FEB012087 2149 forward2 TM N out 8 LI:212029.1:2000FEB012162 2224 forward2 TM N out 9 LI:249170.1:2000FEB01208 282 forward2 TM N in LI:813218.1:2000FEB01466 552 forward1 TM N out 10 LI:813218.1:2000FEB01137 202 forward2 TM N out 10 LI:823218.1:2000FEB01356 436 forward2 TM N out 10 LI:813218.1:2000FEB01452 520 forward2 TM N out 11 LI:902522.3:2000FEB0199 158 forward3 TM N out 22 LI:474304.1:2000FEB0164 147 forward1 TM N in 12 LI:474304.1:2000FEB01217 285 forward1 TM N in 12 LI:474304.1:2000FEB01298 372 forward1 TM N in 22 LI:474304.1:2000FEB0126 88 forward2 TM N out 12 LI:474304.1:2000FEB01110 172 forward2 TM N out 12 LI:474304.2:2000FEB01200 271 forward2 TM N out 12 LI:474304.1:2000FEB01332 418 forward2 TM N out 12 LI:474304.1:2000FEB01890 952 forward2 TM N out 12 LI:474304.1:2000FEB0172 158 forward3 TM N out 12 LI:474304.2:2000FEB01273 332 forward3 TM N out 12 LI:474304.1:2000FEB01330 383 forward3 TM N out 12 LI:474304.1:2000FEB01606 674 forward3 TM N out 13 LI:027320.1:2000FEB01544 603 forward2 TM N out 13 L2:027320.1:2000FEB01694 768 forward1 TM N out Table (cont.) 13 LI:027320.1:2000FEB011102 1182 forward1 TM N out 13 LI:027320.1:2000FEB011280 1236 forward1 TM N out 13 LI:027320.1:2000FEB01545 604 forward2 TM

13 LI:027320.1:2000FEB01851 913 forward2 TM

l3 LI:027320.1:2000FEB01932 994 forward2 TM

13 LI:027320.1:2000FEB021013 1075 forward2 TM

13 LI:027320.1:2000FEB011172 1228 forward2 TM

13 LI:027320.1:2000FEB01579 665 forward3 TM N in 13 LI:027320.1:2000FEB01720 806 forward3 TM N in 13 LI:027320.1:2000FEB01828 908 forward3 TM N in 13 LI:027320.1:2000FEB011020 1103 forward3 TM N in 13 LI:027320.1:2000FEB011116 1202 forward3 TM N in 14 LI:228319.1:2000FEB0176 162 forward1 TM N out 14 LI:228319.1:2000FEB01119 187 forward2 TM N in 14 LI:228319.1:2000FEB01506 592 forward2 TM N in 14 LI:228319.1:2000FEB0163 149 forward3 TM N in 14 LI:228319.1:2000FEB01369 455 forward3 TM N in 14 LI:228319.1:2000FEB01708 770 forward3 TM N in 14 LI:228319.1:2000FEB01786 848 forward3 TM N in 15 LG:197267.2:2000MAY1911 88 forward2 TM N in 15 LG:197267.2:2000MAY19200 271 forward2 TM N in 16 LG:403332.1:2000MAY19352 417 forward1 TM N in 16 LG:403332.1:2000MAY19490 552 forward1 TM N in 16 LG:403332.1:2000MAY19562 624 forward1 TM N in 16 LG:403332.1:2000MAY19721 783 forward1 TM N in 16 LG:403332.1:2000MAY19796 858 forward1 TM N in 16 LG:403332.1:2000MAY19871 948 forward1 TM N in 16 LG:403332.1:2000MAY191012 1098 forward1 TM N in 16 LG:403332.1:2000MAY191138 1188 forward1 TM N in 16 LG:403332.1:2000MAY191192 1278 forward1 TM N in 16 LG:403332.1:2000MAY191453 1530 forward1 TM N in 16 LG:403332.1:2000MAY19365 427 forward2 TM N in 16 LG:403332~.1:2000MAY19521 607 forward2 TM N in 16 LG:403332.1:2000MAY19644 727 forward2 TM N in 16 LG:403332.1:2000MAY19800 886 forward2 TM N in 16 LG:403332.1:2000MAY19911 973 forward2 TM N in 16 LG:403332.1:2000MAY19986 1048 forward2 TM N in 16 LG:403332.1:2000MAY191211 1297 forward2 TM N in 16 LG:403332.1:2000MAY191445 1504 forward2 TM N in 16 LG:403332.1:2000MAY19375 462 forward3 TM

16 LG:403332.1:2000MAY19495 557 forward3 TM

16 LG:403332.1:2000MAY19594 656 forward3 TM

16 LG:403332.1:2000MAY19681 767 forward3 TM

16 LG:403332.1:2000MAY19990 1052 forward3 TM

16 LG:403332.1:2000MAY191077 1139 forward3 TM

16 LG:403332.1:2000MAY191203 1274 forward3 TM

16 LG:403332.1:2000MAY191332 1385 forward3 TM

17 LG:983076.3:2000MAY19479 565 forward2 TM N in 17 LG:983076.3:2000MAY19704 790 forward2 TM N in 17 LG:983076.3:2000MAY19114 200 forward3 TM N out 17 LG:983076.3:2000MAY19261 317 forward3 TM N out 17 LG:983076.3:2000MAY19501 587 forward3 TM N out 17 LG:983076.3:2000MAY19738 794 forward3 TM N out 18 LG:216612.3:2000MAY19120 206 forward3 TM N in 18 LG:216612.3:2000MAY19234 284 forward3 TM N in 18 LG:216612.3:2000MAY19327 413 forward3 TM N in 18 LG:216612.3:2000MAY19444 530 forward3 TM N in 18 LG:216612.3:2000MAY29810 887 forward3 TM N in 19 LG:322465.1:2000MAY19239 319 forward2 TM N out 19 LG:322465.1:2000MAY19276 329 forward3 TM N out Table (cont.) 20 LG:093477.1:2000MAY1925 111 forward1 TM N out 20 LG;093477.1:2000MAY1911 85 forward2 TM N out 20 LG:093477.1:2000MAY19242 295 forward2 TM N out 20 LG:093477.1:2000MAY1924 110 forward3 TM N in 20 LG:093477.1:2000MAY19657 719 forward3 TM N in 22 LG:222880.1:2000MAY19211 297 forward1 TM

21 LG:222880.1:2000MAY191663 1749 forward1 TM

21 LG:222880.1:2000MAY191801 1863 forward1 TM

21 LG:222880.1:2000MAY191906 1968 forward1 TM

21 LG:222880.1:2000MAY192269 2316 forward1 TM

21 LG:222880.1:2000MAY19425 487 forward2 TM N in 21 LG:222880.1:2000MAY19506 568 forward2 TM N in 21 LG:222880.1:2000MAY19611 691 forward2 TM N in 21 LG:222880.2:2000MAY19698 784 forward2 TM N in 21 LG:222880.1:2000MAY19875 961 forward2 TM N in 21 LG:222880.1:2000MAY191016 1078 forward2 TM N in 21 LG:222880.1:2000MAY191106 1168 forward2 TM N in 21 LG:222880.1;2000MAY191544 1630 forward2 TM N in 21 LG:222880.1:2000MAY191691 1774 forward2 TM N in 21 LG:222880.1:2000MAY191940 2026 forward2 TM N in 21 LG:222880.1:2000MAY192315 2395 forward2 TM N in 21 LG:222880.1:2000MAY191710 1784 forward3 TM N out 21 LG:222880.1:2000MAY191809 1895 forward3 TM N out 21 LG:222880.1:2000MAY191926 2009 forward3 TM N out 21 LG:222880.1:2000MAY192064 2129 forward3 TM N out 22 LG:898320.3:2000MAY19151 237 forward1 TM N out 22 LG:898320.3:2000MAY19478 534 forward1 TM N out 22 LG:898320.3:2000MAY19736 822 forward1 TM N out 22 LG:898320.3:2000MAY191528 1599 forward1 TM N out 22 LG:898320.3:2000MAY191663 1710 forward1 TM N out 22 LG:898320.3:2000MAY292017 2088 forward1 TM N out 22 LG:898320.3:2000MAY192131 2184 forward1 TM N out 22 LG:898320.3:2000MAY19719 796 forward2 TM N in ~

22 LG:898320.3:2000MAY191334 1420 forward2 TM N in 22 LG:898320.3:2000MAY191598 1681 forward2 TM N in 22 LG:898320.3:2000MAY191733 1819 forward2 TM N in 22 LG:898320.3:2000MAY191919 1984 forward2 TM N in 22 LG:898320.3:2000MAY192078 2140 forward2 TM N in 22 LG:898320.3:2000MAY192159 2245 forward2 TM N in 22 LG:898320.3:2000MAY1990 176 forward3 TM N out 22 LG:898320.3:2000MAY19411 485 forward3 TM N out 22 LG:898320.3:2000MAY19501 578 forward3 TM N out 22 LG:898320.3:2000MAY19600 686 forward3 TM N out 22 LG:898320.3:2000MAY19783 854 forward3 TM N out 22 LG:898320.3:2000MAY19912 989 forward3 TM N out 22 LG:898320.3:2000MAY191023 1097 forward3 TM N out 22 LG:898320.3:2000MAY191164 1226 forward3 TM N out 22 LG:898320.3:2000MAY191236 1298 forward3 TM N out 22 LG:898320.3:2000MAY191335 1421 forward3 TM N out 2? LG:898320.3:2000MAY192016 2093 forward3 TM N out 22 LG:898320.3:2000MAY192151 2237 forward3 TM N out 23 LG:1327047.1:2000MAY19466 552 forward2 TM N out 23 LG:1327047,2:2000MAY19137 202 forward2 TM N out 23 LG:1327047.1:2000MAY19356 436 forward2 TM N out 23 LG:1327047.1:2000MAY19452 520 forward2 TM N out 23 LG:1327047.1:2000MAY191131 1217 forward3 TM

24 LG:235157.21:2000MAY1911 91 forward2 TM N out 24 LG:235157.21:2000MAY19161 247 forward2 TM N out 24 LG:235157.21:2000MAY19467 529 forward2 TM N out 24 LG:235157.21:2000MAY19551 613 forward2 TM N out Table (cons.) 24 LG:235157.21:2000MAY19686 760 forward2 TM N out 24 LG:235157.21:2000MAY19785 862 forward2 TM N out 25 LG:085713.1:2000MAY1997 183 forward1 TM N out 25 LG:085723.1:2000MAY191489 1575 forward1 TM N out 25 LG:085713.1:2000MAY191786 1854 forward1 TM N out 25 LG:085713.1:2000MAY192275 2361 forward1 TM N out 25 LG:085713.1:2000MAY192407 2493 forward1 TM N out 25 LG:085713.1:2000MAY19134 211 forward2 TM N in 25 LG:085713.1:2000MAY191481 1528 forward2 TM N in 25 LG:085713.1:2000MAY192099 2164 forward2 TM N in 25 LG:085713.1;2000MAY192387 2449 forward2 TM N in 25 LG:085713.1;2000MAY192474 2536 forward2 TM N in 25 LG:085713.1:2000MAY1972 158 forward3 TM N out 25 LG:085713.1:2000MAY191488 1574 forward3 TM N out 25 LG:085713.1:2000MAY192037 2108 forward3 TM N out 25 LG:085713.1:2000MAY192184 2270 forward3 TM N out 25 LG:085713.1:2000MAY192346 2432 forward3 TM N out 26 LG:482421.1:2000MAY19385 456 forward1 TM N out 26 LG:482421.1:2000MAY19715 777 forward1 TM N out 26 LG:482421.1:2000MAY19841 909 forward1 TM N out 26 LG:482421.1:2000MAY19970 1056 forward1 TM N out 26 LG:482421.1:2000MAY191222 1284 forward1 TM N out 26 LG:482421.1:2000MAY191423 1491 forward1 TM N out 26 LG:482421.1:2000MAY192185 2271 forward1 TM N out 26 LG:482421.1:2000MAY192518 2604 forward1 TM N out 26 LG:482421.1:2000MAY192674 2760 forward1 TM N out 26 LG:482421.1:2000MAY1911 64 forward2 TM N out 26 LG:482421.1:2000MAY19260 346 forward2 TM N out 26 LG:482421.1:2000MAY19416 502 forward2 TM N out 26 LG:482421.1:2000MAY19506 586 forward2 TM N out 26 LG:482421.1:2000MAY19857 943 forward2 TM N out 26 LG:482421.1:2000MAY19965 1021 forward2 TM N out 26 LG:482421.1:2000MAY191934 1987 forward2 TM N out 26 LG:482421.1:2000MAY192120 2206 forward2 TM N out 26 LG:482421.1:2000MAY192549 2635 forward2 TM N out 26 LG:482421.1:2000MAY192693 2773 forward2 TM N out 26 LG:482421.1:2000MAY1912 65 forward3 TM N out 26 LG:482421.1:2000MAY19258 332 forward3 TM N out 26 LG:482421.1:2000MAY19603 689 forward3 TM N out 26 LG:482421.1:2000MAY19690 773 forward3 TM N out 26 LG:482421.1:2000MAY19822 905 forward3 TM N out 26 LG:482421.1:2000MAY19972 1028 forward3 TM N out 26 LG:482421.1:2000MAY191074 1130 forward3 TM N out 26 LG:482421.1:2000MAY192403 2489 forward3 TM N out 26 LG:482421.1:2000MAY192550 2636 forward3 TM N out 26 LG:482421.1:2000MAY192673 2753 forward3 TM N out 27 LG:330944.4:2000MAY19389 475 forward2 TM N out 28 LI:223060.1:2000MAY01433 519 forward1 TM N in 28 LI;223060.1:2000MAY011267 1353 forward1 TM N in ;?8LI:223060.1:2000MAY011639 1704 forward1 TM N in 28 LI:223060.1:2000MAY011759 1842 forward1 TM N in 28 LI:223060.1:2000MAY01260 334 forward2 TM N out 28 LI:223060.1:2000MAY01938 1003 forward2 TM N out 28 LI:223060.1:2000MAY011553 1639 forward2 TM N out 28 LI:223060.1:2000MAY011428 1514 forward3 TM N out 29 LI:213087.1:2000MAY01732 818 forward3 TM N in 30 LI:405330.1:2000MAY01103 165 forward1 TM

30 LI:405330.1:2000MAY01406 492 forward1 TM

30 LI:405330.1:2000MAY011276 1362 forward1 TM

30 LI:405330.1:2000MAY011396 1449 forward1 TM

Table (coat.) 30 LI:405330.1:2000MAY011615 1674 forward1 TM

30 LI:405330.1:2000MAY011864 1917 forward1 TM

30 LI:405330.1:2000MAY011966 2016 forward1 TM

30 LI:405330.1:2000MAY012017 2097 forward1 TM

30 LI:405330.1:2000MAY012257 2319 forward1 TM

30 LI:405330.1:2000MAY012329 2397 forwardl TM

30 LI:405330.1:ZOOOMAY012416 2478 forward1 TM

30 LI:405330.1:2000MAY01485 550 forward2 TM N out 30 LI:405330.1:2000MAY01671 757 forward2 TM N out 30 LI:405330.1:2000MAY011283 1357 forward2 TM N out 30 LI:405330.1:2000MAY012511 1579 forward2 TM N out 30 LI:405330.1:2000MAY011877 1933 forward2 TM N out 30 LI:405330.1:2000MAY012339 2395 forward2 TM N out 30 LI:405330.1:2000MAY012411 2473 forward2 TM N out 30 LI;405330.1:2000MAY01249 320 forward3 TM N in 30 LI:405330.1:2000MAY01678 764 forward3 TM N in 30 LI;405330.1:2000MAY01990 1070 forward3 TM N in 30 LI:405330.2:2000MAY011650 1721 forward3 TM N in 30 LI:405330.1:2000MAY012265 2351 forward3 TM N in 30 LI:405330.1:2000MAY012433 2513 forward3 TM N in 31 LI:350243.2:2000MAY013799 3852 forward1 TM

31 LI:350243.2:2000MAY014453 4533 forward1 TM

31 LI:350243.2:2000MAY015392 5460 forward1 TM

31 LI:350243.2:2000MAY015944 6030 forward1 TM

31 LI:350243.2:2000MAY016256 6333 forward1 TM

31 LI:350243.2:2000MAY017003 7071 forward1 TM

31 LI:350243,2:2000MAY017333 7398 forward1 TM

31 LI:350243.2:2000MAY017552 7626 forward1 TM

31 LI:350243.2:2000MAY017780 7845 forward1 TM

31 LI:350243.2:2000MAY017867 7923 forward1 TM

31 LI:350243.2:2000MAY017954 8025 forward1 TM

31 LI:350243.2:2000MAY018407 8490 forward1 TM

31 LI:350243.2:2000MAY014361 4447 forward2 TM N out 31 LI:350243.2:2000MAY014724 4807 forward2 TM N out 31 LI:350243.2:2000MAY015402 5488 forward2 TM N out 31 LI:350243.2:2000MAY015618 5668 forward2 TM N out 31 LT:350243.2:2000MAY015687 5767 forward2 TM N out 31 LI:350243.2:2000MAY016263 6334 forward2 TM N out 31 LI:350243.2:2000MAY016488 6574 forward2 TM N out 31 LI:350243.2:2000MAY017610 7696 forward2 TM N out 32 LI:350243.2;2000MAY027814 7900 forward2 TM N out 31 LI:350243.2:2000MAY017991 8047 forward2 TM N out 31 LI:350243.2:2000MAY018501 8587 forward2 TM N out 31 LI:350243.2:2000MAY018699 8785 forward2 TM N out 31 LI:350243.2:2000MAY013975 4052 forward3 TM N in 31 LI:350243.2:2000MAY015037 5108 forward3 TM N in 31 LI:350243.2:2000MAY016090 6155 forward3 TM N in 31 LI:350243.2:2000MAY016276 6338 forward3 TM N in 31 LI:350243.2:2000MAY016357 6419 forward3 TM N in 31 LI:350243.2:2000MAY016492 6557 forward3 TM N in 31 LI:350243.2:2000MAY017005 7055 forward3 TM N in 31 LI:350243.2:2000MAY017185 7271 forward3 TM N in 31 LI:350243.2:2000MAY017365 7439 forward3 TM N in 31 LI:350243.2:2000MAY017650 7727 forward3 TM N in 31 LI:350243.2:2000MAY017818 7868 forward3 TM N in 31 LI:350243.2:2000MAY017881 7949 forward3 TM N in 31 LI:350243.2:2000MAY018445 8507 forward3 TM N in 31 LI:350243.2:2000MAY018526 8585 forward3 TM N in 32 LI:445188.1:2000MAY0110 63 forward1 TM N in 32 LI:445188.1:2000MAY01169 240 forward1 TM N in Table (cont.) 32 LI:445188,1:2000MAY01337 408 forward1 TM N in 32 LI:445188.1:2000MAY01406 471 forward1 TM N in 32 LI:445188,1:2000MAY01796 861 forward1 TM N in 32 LI:445188.1:2000MAY01967 1041 forward1 TM N in 32 LI:445188.1:2000MAY011135 1209 forward1 TM N in 32 LI:445188.1:2000MAY011228 1314 forward1 TM N in 32 LI:445188.1:2000MAY011396 1473 forward1 TM N in 32 LI:445188.1:2000MAY01131 217 forward2 TM N in 32 LI:445188.1:2000MAY01335 421 forward2 TM N in 32 LI:445188.1:2000MAY01980 1042 forward2 TM N in 32 LI:445188.1:2000MAY011136 1189 forward2 TM N in 32 LI:445188.1:2000MAY011445 1522 forward2 TM N in 32 LI:445188.1:2000MAY0112 59 forward3 TM N out 32 LI:445188.1:2000MAY01135 221 forward3 TM N out 32 LI:445188.1:2000MAY01258 344 forward3 TM N out 32 LI:445188.1:2000MAY01351 431 forward3 TM N out 32 LI:445188.1:2000MAY01573 650 forward3 TM N out 32 LI:445188.1:2000MAY01819 893 forward3 TM N out 32 LI:445188.1:2000MAY011008 1094 forward3 TM N out 32 LI:445188.1:2000MAY011149 1235 forward3 TM N out 32 LI:445188.1:2000MAY011695 1763 forward3 TM N out 33 LI:244378.1:2000MAY0128 114 forward1 TM N out 33 LI:244378.1:2000MAY01403 462 forward1 TM N out 33 LI:244378.1:2000MAY01466 549 forward1 TM N out 33 LI:244378.1:2000MAY011972 2058 forward1 TM N out 33 LI:244378.1:2000MAY0111 76 forward2 TM N in 33 LI:244378.1:2000MAY01401 487 forward2 TM N in 33 LI:244378.1:2000MAY01533 619 forward2 TM N in 33 LI:244378.1:2000MAY011313 1369 forward2 TM N in 33 LI:244378.1:2000MAY011985 2035 forward2 TM N in 33 LI:244378.1:2000MAY0124 86 forward3 TM N out 33 LI:244378.1:2000MAY01108 170 forward3 TM N out 33 LI:244378.1:2000MAY011980 2045 forward3 TM N out 34 LI:236574.15:2000MAY011 81 forward1 TM N out 34 LI:236574.15:2000MAY0197 183 forward1 TM N out 34 LI:236574.15:2000MAY0195 166 forward2 TM N out 34 LI:236574.15:2000MAY01239 325 forward2 TM N out 34 LI:236574.15:2000MAY0193 155 forward3 TM N in 35 LI:010100.20:2000MAY0143 96 forward1 TM N in 35 LI:010100.20:2000MAY01169 255 forward1 TM N in 35 LI:010100.20:2000MAY01328 399 forward1 TM N in 35 LI:010100.20:2000MAY01658 720 forward1 TM N in 35 LI:010100.20:2000MAY01742 804 forward1 TM N in 35 LI:010100.20:2000MAY01910 996 forward1 TM N in 35 LI:020100.20:2000MAY011117 1203 forward1 TM N in 35 LI:010100.20:2000MAY011240 1317 forward1 TM N in 35 LI:010100.20:2000MAY011528 1611 forward1 TM N in 35 LI:010100.20:2000MAY011822 1908 forward1 TM N in 35 LI:010100.20:2000MAY012206 2280 forward1 TM N in 35 LI:010100.20:2000MAY012671 2754 forward1 TM N in 35 LI:010100.20:2000MAY012899 2973 forward2 TM N in 35 LI:010100.20:2000MAY013037 3123 forward1 TM N in 35 LI:010100.20:2000MAY013349 3435 forward1 TM N in 35 LI:010100.20:2000MAY0126 109 forward2 TM N in 35 LI:010100.20:2000MAY01146 232 forward2 TM N in 35 LI:010100.20:2000MAY01530 592 forward2 TM N in 35 LI:010100.20:2000MAY01743 796 forward2 TM N in 35 LI:010100.20:2000MAY01953 1039 forward2 TM N in 35 LI:010100.20:2000MAY011154 1207 forward2 TM N in 35 LI:010100.20:2000MAY011274 1360 forward2 TM N in Table (cont.) 35 LI:010100.20:2000MAY011364 1435 forward2 TM N in 35 LI:010100.20:2000MAY011544 1630 forward2 TM N in 35 LI:010100.20:2000MAY011748 1822 forward2 TM N in 35 LI:010100.20:2000MAY011922 2008 forward2 TM N in 35 LI:010100.20:2000MAY012354 2440 forward2 TM N in 35 LI:010100.20:2000MAY012663 2731 forward2 TM N in 35 LI:010100.20:2000MAY012732 2818 forward2 TM N in 35 LI:010100.20:2000MAY013287 3373 forward2 TM N in 35 LI:010100.20:2000MAY013386 3472 forward2 TM N in 35 LI:010100.20:2000MAY01141 227 forward3 TM

35 LT:010100.20:2000MAY01375 452 forward3 TM

35 LI:010100.20:2000MAY01768 824 forward3 TM

35 LT:010100.20:2000MAY01969 1049 forward3 TM

35 LI:010100.20:2000MAY011146 1214 forward3 TM

35 LT:010100.20:2000MAY011281 1367 forward3 TM

35 LI:010100.20:2000MAY011590 1652 forward3 TM

35 LI:010100.20:2000MAY011704 1766 forward3 TM

35 LI:010100.20:2000MAY011908 1976 forward3 TM

35 LI:010100.20:2000MAY012208 2294 forward3 TM

35 LI:010100.20:2000MAY012700 2762 forward3 TM

35 LI:010100.20:2000MAY012781 2843 forward3 TM

35 LI:010100.20:2000MAY012862 2924 forward3 TM

35 LI:010100.20:2000MAY012946 3020 forward3 TM

35 LI:010100.20:2000MAY013051 3131 forward3 TM

35 LI:010100.20:2000MAY013135 3206 forward3 TM

35 LI:010100.20:2000MAY013324 3389 forward3 TM

36 LI:037940.6:2000MAY01163 249 forward1 TM N in 36 LI:037940.6:2000MAY0114 100 forward2 TM

36 LI:037940.6:2000MAY01161 247 forward2 TM

36 LI:037940.6:2000MAY01365 451 forward2 TM

36 LI:037940.6:2000MAY0112 92 forward3 TM N out 36 LT:037940.6:2000MAY01387 473 forward3 TM N out 37 LI:228550.3:2000MAY011537 1602 forward1 TM N in 37 LI:228550.3:2000MAY011603 1680 forward1 TM N in 37 LI:228550.3:2000MAY011846 1899 forward1 TM N in 37 LI:228550.3:2000MAY014165 4239 forward1 TM N in 37 LI:228550.3:2000MAY014549 4629 forward1 TM N in 37 LI:228550.3:2000MAY014651 4737 forward1 TM N in 37 LI:228550.3:2000MAY015371 5430 forward1 TM N in 37 LI:228550.3:2000MAY017300 7362 forward1 TM N in 37 LI:228550.3:2000MAY017408 7470 forward1 TM N in 37 LI:228550.3:2000MAY017582 7659 forward1 TM N in 37 LI:228550.3:2000MAY011622 1678 forward2 TM N in 37 LI:228550.3:2000MAY011718 1804 forward2 TM N in 37 LI:228550.3:2000MAY011841 1927 forward2 TM N in 37 LI:228550.3:2000MAY011976 2038 forward2 TM N in 37 LI:228550.3:2000MAY012066 2128 forward2 TM N in 37 LI:228550.3:2000MAY012150 2236 forward2 TM N in 37 LI:228550.3:2000MAY012546 2608 forward2 TM N in 37 LI:228550.3:2000MAY013746 3829 forward2 TM N in 37 LI:228550.3:2000MAY014457 4543 forward2 TM N in 37 LI:228550.3:2000MAY014724 4810 forward2 TM N in 37 L2:228550.3:2000MAY017229 7303 forward2 TM N in 37 LI:228550.3:2000MAY017637 7723 forward2 TM N in 37 LI:228550.3:2000MAY013978 4031 forward3 TM N in 37 LI:228550.3:2000MAY014362 4424 forward3 TM N in 37 LI:228550.3:2000MAY014440 4502 forward3 TM N in 37 LI:228550.3:2000MAY014575 4637 forward3 TM N in 37 LI:228550.3:2000MAY014671 4733 forwaxd3 TM N in 37 LI:228550.3:2000MAY015070 5135 forward3 TM N in Table (cont.) 37 LI:228550.3:2000MAY016963 7049 forward3 TM N in 37 LI:228550.3:2000MAY027308 7361 forward3 TM N in 37 LI:228550.3:2000MAY017482 7535 forward3 TM N in 37 LI:228550.3:2000MAY017617 7703 forward3 TM N in 38 LI:027320.1:2000MAY01637 723 forward1 TM N in 38 LI:027320.1:2000MAY01796 882 forward1 TM N in 38 LI:027320.2:2000MAY01970 1050 forward2 TM N in 38 LI:027320.1:2000MAY011081 1167 forward1 TM N in 38 LI:027320.1:2000MAY01692 778 forward2 TM N in 38 LI:027320.1:2000MAY01857 928 forward2 TM N in 38 LI:027320.1:2000MAY01932 1012 forward2 TM N in 38 LI:027320.1:2000MAY011079 1165 forward2 TM N in 38 LI:027320.1:2000MAY011220 1306 forward2 TM N in 38 LI:027320.1:2000MAY011032 1118 forward3 TM N out 38 LI:027320.1:2000MAY011128 1190 forward3 TM N out 38 LI:027320.1:2000MAY011242 1292 forward3 TM N out 39 LI:321475.1:2000MAY01610 681 forward1 TM N out 39 LI;321475.1:2000MAY011081 1167 forward1 TM N out 39 LI:321475.1:2000MAY011207 1284 forward1 TM N out 39 LI;321475.1:2000MAY01125 187 forward2 TM N out 39 LI:321475.1:2000MAY01200 262 forward2 TM N out 39 LI:321475.2:2000MAY01356 442 forward2 TM N out 39 LI:321475.1:2000MAY01641 727 forward2 TM N out 39 LI:321475.1:2000MAY01791 877 forward2 TM N out 39 LI:321475.1:2000MAY01920 982 forward2 TM N out 39 LI:321475.1:2000MAY011013 1075 forward2 TM N out 39 LI:321475.1:2000MAY011124 1186 forward2 TM N out 39 LI:321475.1:2000MAY011202 1264 forward2 TM N out 39 LI:321475.1:2000MAY011409 1495 forward2 TM N out 39 LI:321475.1:2000MAY01822 908 forward3 TM N in 39 LI:321475.1:2000MAY011125 1208 forward3 TM N in 40 LI:899552.5:2000MAY01286 351 forward1 TM N in 40 LI:899552.5:2000MAY01970 1056 forward1 TM N in 40 LI:899552.5:2000MAY011114 1176 forward1 TM N in 40 LI:899552.5:2000MAY011900 1947 forward1 TM N in 40 LI:899552.5:2000MAY011079 1165 forward2 TM N in 40 LI:899552.5:2000MAY011691 1765 forward2 TM N in 40 LI:899552.5:2000MAY01834 896 forward3 TM N in 40 LI:899552.5:2000MAY01915 977 forward3 TM N in 40 LI:899552.5:2000MAY01996 1058 forward3 TM N in 41 LI:1071848.1:2000MAY01961 1020 forward1 TM N out 41 LI:1071848.1:2000MAYOl1117 1194 forward1 TM N out 41 LI:1071848.1:2000MAY011058 1144 forward2 TM N out 41 LI:1071848.1:2000MAY01996 1067 forward3 TM N in 41 LI:1071848.1:2000MAY011080 1142 forward3 TM N in 41 LI:1071848.1:2000MAY011155 1217 forward3 TM N in 42 LI:1072337.2:2000MAY0149 135 forward1 TM N out 42 LI:1072337.2:2000MAY01463 525 forward1 TM N out 42 LI:1072337.2:2000MAY01652 726 forward1 TM N out 42 LI:1072337.2:2000MAY012344 2397 forward1 TM N out 42 LI:1072337.2:2000MAY012518 2589 forward1 TM N out 42 LT:1072337.2:2000MAY012614 2667 forward1 TM N out 42 LI:1072337.2:2000MAY012923 3000 forward1 TM N out 42 LI:1072337.2:2000MAY013181 3252 forward1 TM N out 42 LI:1072337.2:2000MAY013577 3657 forward1 TM N out 42 LI:1072337.2:2000MAY014264 4344 forward1 TM N out 42 LI:1072337.2:2000MAY0177 136 forward2 TM N out 42 LI:1072337.2:2000MAY01230 316 forward2 TM N out 42 LI:1072337.2:2000MAY011997 2047 forward2 TM N out 42 LI:1072337.2:2000MAY012057 2125 forward2 TM N out Table (cont.) 42 LI:2072337.2:2000MAY0126092686 forward2 TM N out 42 LI:1072337.2:2000MAY0128612914 forward2 TM N out 42 LI:1072337.2:2000MAY0132423328 forward2 TM N out 42 LI:1072337.2:2000MAY0134403496 forward2 TM N out 42 LI:1072337.2:2000MAY0135873673 forward2 TM N out 42 LI:1072337.2:2000MAY0143914468 forward2 TM N out 42 LI:1072337.2:2000MAY0123822435 forward3 TM N in 42 LI:1072337.2:2000MAY0125292594 forward3 TM N in 42 LI:1072337.2:2000MAY0128772948 forward3 TM N in 42 LI:1072337.2:2000MAY0129943065 forward3 TM N in 42 LI:1072337.2:2000MAY0136183695 forward3 TM N in 42 LI:1072337.2:2000MAY0143864460 forward3 TM N in 43 LI:251489.5:2000MAY01 31 127 forward1 TM N out 43 LI:251489.5:2000MAY01 44 130 forward2 TM N out 44 LI:902018.107:2000MAY01595 681 forward1 TM N out 44 LI:902018.107:2000MAY0114291515 forward1 TM N out 44 LI:902018.107:2000MAY0120982184 forward1 TM N out 44 LI:902018.107:2000MAY0123412409 forward1 TM N out 44 LI:902018.107:2000MAY0128332895 forward1 TM N out 44 LI:902018.107:2000MAY0129262988 forward1 TM N out 44 LI:902018.107:2000MAY0136163666 forward1 TM N out 44 LI:902018.107:2000MAY0137663837 forward1 TM N out 44 LI:902018.107:2000MAY0139373990 forward1 TM N out 44 LI:902018.107:2000MAY0126752761 forward2 TM N in 44 LI:902018.107:2000MAY0136113697 forward2 TM N in 44 LI:902018.107:2000MAY0140434117 forward2 TM N in 44 LI:902018.107:2000MAY0141514237 forward2 TM N in 44 LI:902018.107:2000MAY0130573143 forward3 TM N in 44 LI:902018.107:2000MAY0135553638 forward3 TM N in 44 LI:902018.107:2000MAY0136813734 forward3 TM N in 44 LI:902018.107:2000MAY0139153977 forward3 TM N in 44 LI:902018.107:2000MAY0140024064 forward3 TM N in 44 LI:902018,207:2000MAY0140804160 forward3 TM N in 44 LI:902018.107:2000MAY0142704226 forward3 TM N in 45 LI:220495.1:2000MAY01 91 150 forward1 TM N out 45 LI:220495.1:2000MAY01 205 291 forward1 TM N out 45 LI:220495.1:2000MAY01 499 579 forward1 TM N out 45 LI:220495.1:2000MAY01 637 699 forward1 TM N out 45 LI:220495.1:2000MAY01 718 780 forward1 TM N out 45 LI:220495.1:2000MAY01 853 936 forward1 TM N out 45 LI:220495.1:2000MAY01 994 1080 forward1 TM N out 45 LI:220495.1:2000MAY01 15131590 forward1 TM N out 45 LI:220495.1:2000MAY01 15911671 forward1 TM N out 45 LI:220495.1:2000MAY01 17021788 forward1 TM N out 45 LI:220495.1:2000MAY01 19392022 forward1 TM N out 45 LI:220495.1:2000MAY01 23442430 forward1 TM N out 45 LI:220495.1:2000MAY01 25422592 forward1 TM N out 45 LI:220495.1:2000MAY01 779 832 forward2 TM N in 45 LI:220495.1:2000MAY01 851 916 forward2 TM N in 45 LI:220495.1:2000MAY01 14181504 forward2 TM N in 45 LI;220495.1:2000MAY01 15891642 forward2 TM N in 45 LI:220495.1:2000MAY01 16821768 forward2 TM N in 45 LI:220495.1:2000MAY01 18231885 forward2 TM N in 45 LI:220495.1:2000MAY01 18981960 forward2 TM N in 45 LI:220495.1:2000MAY01 28942974 forward2 TM N in 45 LI:220495.1:2000MAY01 486 536 forward3 TM N in 45 LI:220495.1:2000MAY01 618 677 forward3 TM N in 45 LI:220495.1:2000MAY01 960 1034 forward3 TM N in 45 LT:220495.1:2000MAY01 16921751 forward3 TM N in 45 LI:220495.1:2000MAY01 18121895 forward3 TM N in Table (cont.) 45 LI:220495.1:2000MAY011932 1991 forward3 TM N in 45 LI:220495.1:2000MAY012307 2366 forward3 TM N in 45 LI:220495.1:2000MAY012391 2462 forward3 TM N in 45 LI:220495.1:2000MAY012835 2921 forward3 TM N in 45 LI:220495.1:2000MAY012970 3056 forward3 TM N in 46 LI:399478.1:2000MAY01823 885 forward1 TM N in 46 LI:399478.1:2000MAY01982 1059 forward1 TM N in 46 LI:399478.1:20DOMAY011087 2173 forward1 TM N in 46 LI:399478.1:2000MAY011330 1416 forward1 TM N in 46 LI:399478.1:2000MAY011639 1716 forward1 TM N in 46 LI:399478.1:2000MAY011756 1836 forward1 TM N in 46 LI:399478.1:2000MAY011849 1899 forward1 TM N in 46 LI:399478.1:2000MAY012497 2574 forward1 TM N in 46 LI:399478.1:2000MAY012726 2772 forward1 TM N in 46 LI:399478.1:2000MAY01107 178 forward2 TM N out 46 LT:399478.1:2000MAY011025 1087 forward2 TM N out 46 LI:399478.1:2000MAY011103 1165 forward2 TM N out 46 LI:399478.1:2000MAY011640 1702 forward2 TM N out 46 LI:399478.1:2000MAY011718 1780 forward2 TM N out 46 LI:399478.1:2000MAY012D63 2149 forward2 TM N out 46 LI:399478.1:2000MAY01519 605 forward3 TM N in 46 LI:399478.1:2000MAYOl834 914 forward3 TM N in 46 LI:399478.1:2000MAY011014 1076 forward3 TM N in 46 LI:399478.1:2000MAY011101 1263 forward3 TM N in 46 LI:399478.1;2000MAY011386 1439 forward3 TM N in 46 LI:399478.1:2000MAY011509 1595 forward3 TM N in 46 LI:399478.1;2000MAY011659 1745 forward3 TM N in 46 LI:399478.1:2000MAY011803 1886 forward3 TM N in 46 LI:399478.1:2000MAY012583 2669 forward3 TM N in 47 LI:229648.2:2000MAY01556 606 forward1 TM

47 LI:229648.2:2000MAY011009 1095 forward1 TM

47 LI:229648.2:2000MAY011324 1410 forward1 TM

47 LI:229648.2:2000MAY011633 1719 forward1 TM

47 LI:229648.2:2000MAY011840 1914 forward1 TM

47 LI:229648.2:2000MAY01776 832 forward2 TM N in 47 LI:229648.2:2000MAY01983 1069 forward2 TM N in 47 LI:229648.2:2000MAY011610 1663 forward2 TM N in 47 LI:229648.2:2000MAY011862 1921 forward2 TM N in 47 LI:229648.2:2000MAY01726 812 forward3 TM N in 47 LI:229648.2:2000MAY011002 1088 forward3 TM N in 47 LI:229648.2:2DOOMAY011533 1589 forward3 TM N in 47 LI:229648.2:2000MAY011641 1727 forward3 TM N in 47 LI:229648.2:2000MAY011809 1895 forward3 TM N in 48 LI:025643.2:2000MAY011526 1591 forward2 TM

48 LI:025643.2:2000MAY011542 1598 forward3 TM N out 49 LI:233942.1:2000MAY01184 270 forward1 TM N out 49 LI:233942.1:2000MAY01541 627 forward1 TM N out 49 LI:233942.1:2000MAY01671 745 forward2 TM N out 49 LI:233942.1:2000MAY011352 1438 forward2 TM N out 49 LI:233942.1:2000MAY011715 1768 forward2 TM N out 49 LI:233942.1:2000MAY012021 2104 forward2 TM N out 49 LI:233942.1:2000MAY01138 221 forward3 TM N in 49 LI:233942.1:2000MAY01558 614 forward3 TM N in 49 LI:233942.1:2000MAY01684 758 forward3 TM N in 49 LI:233942.1:2000MAY011179 1256 forward3 TM N in 49 LI:233942.1:2000MAY021986 2057 forward3 TM N in 50 LI:089158.1:2000MAY012443 2526 forward1 TM N out 50 LI:089158.1:2000MAY012602 2652 forward1 TM N out 50 LI:089158.1:2000MAY013772 3858 forward1 TM N out 50 LI:089158.1:20OOMAY011052 1120 forward2 TM N in Table (cont.) 50 LI:089158.1:2000MAY011523 1597 forward2 TM N in 50 LI:089158.1:2000MAY011643 1729 forward2 TM N in 50 LI:089158.1:2000MAY012396 2476 forward2 TM N in 50 LI:089158.1:2000MAY013335 3421 forward2 TM N in 50 LI:089158.1:2000MAY011020 1100 forward3 TM N in 50 LI:089158.1:2000MAY011497 1583 forward3 TM N in 50 LI:089158.1:2000MAY012722 1790 forward3 TM N in 50 LI:089158.1:2000MAY013069 3146 forward3 TM N in 51 LI:101046.1:2000MAY01292 378 forward1 TM N out 51 LT:101046.1:2000MAY01811 897 forward1 TM N out 51 LT:101046.1:2000MAY011261 1308 forward1 TM N out 51 LI:101046.1:2000MAY01368 451 forward2 TM N in 51 LI:101046.1:2000MAY01827 913 forward2 TM N in 51 LI:101046.1:2000MAY012102 2188 forward2 TM N in 51 LI:101046.1:2000MAY01711 785 forward3 TM N out 51 LI:101046.1:2000MAY01873 932 forward3 TM N out 51 LI:101046.1:2000MAY011002 1079 forward3 TM N out 52 LI:368676.2:2000MAY012077 2163 forward1 TM

52 LI:368676.2:2000MAY013079 3165 forward1 TM

52 LI:368676.2:2000MAY012984 3058 forward2 TM N in 52 LI:368676.2:2000MAY012937 3023 forward3 TM

53 LI:238713.1:2000MAY01844 930 forward1 TM

53 LI:238713.2:2000MAY01120 184 forward2 TM N out 53 LI:238713.1:2000MAY01194 256 forward2 TM N out 53 LI:238713.1:2000MAY01728 814 forward2 TM N out 53 LI:238713.1:2000MAY01297 383 forward3 TM N out 53 LI:238713.1:2000MAY01423 485 forward3 TM N out 53 LI:238713.1:2000MAY01570 656 forward3 TM N out 53 LI:238713.1:2000MAY01696 782 forward3 TM N out 53 LI:238713.1:2000MAY012101 1154 forward3 TM N out 53 LI:238713.1:2000MAY011635 1721 forward3 TM N out 54 LI:720928.1:2000MAY01208 264 forward1 TM N out 54 LI:720928.1:2000MAY01637 693 forward1 TM N out 55 LI:221874.1:2000MAY01877 954 forward1 TM N out 55 LI:221874.1:2000MAY012086 2172 forward1 TM N out 55 LI:221874.1:2000MAY011187 1258 forward2 TM N out 55 LI:221874.1:2000MAY012171 2230 forward2 TM N out 55 LI:221874.1:2000MAY01348 434 forward3 TM N in 55 LI:221874.1:2000MAY011116 1190 forward3 TM N in 56 LI:1143545.3:2000MAY01458 523 forward2 TM

56 LI:1143545.3:2000MAY012144 2230 forward2 TM

57 LI:1143605.1:2000MAY01349 435 forward1 TM N in 57 LI:1143605.1:2000MAY01445 528 forward1 TM N in 57 L2:1143605.1:2000MAY01544 624 forward1 TM N in 57 LI:1243605.1:2000MAY01775 861 forward1 TM N in 57 LI:1143605.1:2000MAY011202 1188 forward1 TM N in 57 LI:1143605.1:2000MAY011240 1302 forward1 TM N in 57 LI:1143605.1:2000MAY011378 1464 forward1 TM N in 57 LI:1143605.1:2000MAY011726 1800 forward1 TM N in 57 LI:1143605.1:2000MAY011828 1890 forward1 TM N in 57 LI:1143605.1:2000MAY011918 1980 forward1 TM N in 57 LI:1143605.1:2000MAY0117 82 forward2 TM N out 57 LI:2143605.1:2000MAY01368 445 forward2 TM N out 57 LI:1143605.1:2000MAY01632 718 forward2 TM N out 57 LI:1143605.1:2000MAY01899 958 forward2 TM N out 57 LI:1143605.1:2000MAY011043 1102 forward2 TM N out 57 LI:1143605.1:2000MAY011157 1243 forward2 TM N out 57 LI:1143605.1:2000MAY011607 1681 forward2 TM N out 57 LI:1143605.1:2000MAY011766 1849 forward2 TM N out 57 LI:1143605.1:2000MAY011859 1927 forward2 TM N out Table (cont.) 57 LI:1143605.1:2000MAY011940 1999 forward2 TM N out 57 LI:1143605,1:2000MAY01351 437 forward3 TM N out 57 LI:1143605.2:2000MAY01513 584 forward3 TM N out 57 LI:1143605.1:2000MAY01735 821 forward3 TM N out 57 LI:1143605.1:2000MAY011326 1412 forward3 TM N out 57 LI:1143605.1:2000MAY011446 1526 forward3 TM N out 57 LI:1143605.1:2000MAY011605 1688 forward3 TM N out 57 LI:1143605.1:2000MAY011806 1868 forward3 TM N out 57 LI:1143605.1:2000MAY011893 1955 forward3 TM N out 58 LI:474069.7:2000MAY01706 783 forward1 TM

58 LI:474069.7:2000MAY011366 1428 forward1 TM

58 LI:474069.7:2000MAY011738 1824 forward1 TM

58 LI:474069.7:2000MAY01698 748 forward2 TM N in 58 LI:474069.7:2000MAY01965 1051 forward2 TM N in 58 LI:474069.7:2000MAY011241 1300 forward2 TM N in 58 LI:474069.7:2000MAY011487 1537 forward2 TM N in 58 LI:474069.7:2000MAY012030 2107 forward2 TM N in 58 LI:474069.7:2000MAY0127 92 forward3 TM N in 58 LI:474069.7:2000MAY01699 785 forward3 TM N in 58 LI:474069.7:2000MAY01936 1001 forward3 TM N in 58 LI:474069.7:2000MAY011929 2003 forward3 TM N in 59 L2:245193.3:2000MAY011195 1275 forward1 TM N in 59 LI:245193.3:2000MAY011579 1656 forward1 TM N in 59 LI:245193.3:2000MAY011789 1860 forward1 TM N in 59 LI:245193.3:2000MAY012029 2091 forward1 TM N in 59 LI:245193.3:2000MAY011562 1621 forward2 TM N in 59 LI:245193.3:2000MAY011880 1957 forward2 TM N in 59 LI:245193.3:2000MAY012156 2206 forward2 TM N in 59 LI:245193.3:2000MAY012513 2575 forward2 TM N in 59 LI:245193.3:2000MAY012591 2653 forward2 TM N in 59 LI:245193.3:2000MAY012669 2731 forward2 TM N in 59 LI:245193.3:2000MAY011548 1634 forward3 TM N in 59 LI:245193.3:2000MAY011659 1745 forward3 TM N in 59 LI:245193.3:2000MAY012154 2231 forward3 TM N in 59 LI:245193.3:2000MAY012364 2450 forward3 TM N in 59 LI:245193.3:2000MAY012571 2618 forward3 TM N in 59 LI:245193.3:2000MAY012649 2735 forward3 TM N in 60 LI:403872.1:2000MAY01562 624 forward1 TM

60 LI:403872.1:2000MAY01730 780 forward1 TM

60 LI:403872.1:2000MAY011498 1575 forward1 TM

60 LI:403872.1:2000MAY011648 1722 forward1 TM

60 LI:403872.1:2000MAY012359 2433 forward1 TM

60 LI:403872.1:2000MAY01371 454 forward2 TM N in 60 LI:403872.1:2000MAY01731 781 forward2 TM N in 60 LI:403872.1:2000MAY01956 1012 forward2 TM N in 60 LI:403872.1:2000MAY011106 1192 forward2 TM N in 60 LI:403872.1:2000MAY011541 1600 forward2 TM N in 60 LI:403872.1:2000MAY011661 1747 forward2 TM N in 60 LI:403872.1:2000MAY011994 2050 forward2 TM N in 60 LI:403872.1:2000MAY012261 2332 forward2 TM N in 60 LI:403872.1:2000MAY012357 2443 forward2 TM N in 60 LI:403872.1:2000MAY01543 629 forward3 TM N out 60 LI:403872.1:2000MAY01708 782 forward3 TM N out 60 LI:403872.1:2000MAY011530 1601 forward3 TM N out 60 LI:403872.1:2000MAY011656 1715 forward3 TM N out 60 LI:403872.1:2000MAY011983 2069 forward3 TM N out 60 LI:403872.1:2000MAY012145 2225 forward3 TM N out 60 LI:403872.1:2000MAY012226 2309 forward3 TM N out 60 LI:403872.1:2000MAY012349 2426 forward3 TM N out 61 LI:1086294.1:2000MAY01748 834 forward1 TM N out Table (cont.) 61 LI:1086294.1:2000MAY012278 2352 forward1 TM N out 61 LI:1086294.1:2000MAY012306 2356 forward2 TM N out 62 LI:337514.3:2000MAY011906 1992 forward1 TM N in 62 LT:337514.3:2000MAY011512 1598 forward3 TM N out 63 LI:230711.1:2000MAY01898 978 forward1 TM N out 63 LI:230711.1:2000MAY011327 1389 forward1 TM N out 63 LI:230711.1:2000MAY012059 2145 forward1 TM N out 63 LI:230711.1:2000MAY01134 220 forward2 TM N out 63 LI:230711.1:2000MAY011517 1591 forward2 TM N out 63 LI:230711.1:2000MAY011631 1708 forward2 TM N out 63 LI:230711.1:2000MAY012033 2119 forward2 TM N out 63 LI:230711.1:2000MAY01214 188 forward3 TM N in 63 LI:230711.1:2000MAY01570 620 forward3 TM N in 63 LI:230711.1:2000MAY01648 716 forward3 TM N in 63 LI:230711.1:2000MAY011101 1160 forward3 TM N in 64 LI:040338.2:2000MAY01794 880 forward2 TM N in 64 LI:040338.2:2000MAY01162 233 forward3 TM N out 64 LI:040338.2:2000MAY01708 791 forward3 TM N out 65 LI:399174.2:2000MAY01622 693 forward1 TM

65 LI:399174.2:2000MAY01958 1008 forward1 TM

65 LI:399174.2:2000MAY011027 1080 forward1 TM

65 LI:399174.2:2000MAY011303 1377 forward1 TM

65 LI:399174.2:2000MAY01965 1018 forward2 TM N in 65 LI:399174.2:2000MAY01126 200 forward3 TM N out 66 LI:197275.5:2000MAY01211 285 forward1 TM N out 66 LI:197275.5:2000MAY01761 811 forward2 TM N out 66 LI:197275.5:2000MAY01210 281 forward3 TM N out 66 LI:197275.5:2000MAY01537 623 forward3 TM N out 67 LI:336872.1:2000MAY01175 231 forward1 TM N out 67 LI:336872.1:2000MAY011099 1185 forward1 TM N out 67 LI:336872.1:2000MAY011450 1536 forward1 TM N out 67 LI:336872.1:2000MAY01182 247 forward2 TM N in 67 LI:336872.1:2000MAY011001 1072 forward2 TM N in 67 LI:336872.1:2000MAY011169 1246 forward2 TM N in 67 LI:336872.1:2000MAY011373 1447 forward2 TM N in 67 LI:336872.1:2000MAY01171 224 forward3 TM N out 67 LT:336872.1:2000MAY011089 1175 forward3 TM N out 67 LI:336872.1:2000MAY011302 1364 forward3 TM N out 68 LI:1092901.1:2000MAY01272 258 forward1 TM N out 68 LI:1092901.1:2000MAY01299 379 forward2 TM N out 68 LI:1092901.1:2000MAY01425 511 forward2 TM N out 69 LI:022387.5:2000MAY011195 1281 forward1 TM N out 69 LI:022387.5:2000MAY01710 796 forward2 TM N out 69 LI:022387.5:2000MAY011214 1276 forward2 TM N out 69 LI:022387.5:2000MAY01675 743 forward3 TM N out 69 LI:022387.5:2000MAY011092 1175 forward3 TM N out 69 LI:022387.5:2000MAY011215 1301 forward3 TM N out 70 LI:1188334.1:2000MAY01208 294 forward1 TM N out 70 LI:1188334.1:2000MAY01370 456 forward1 TM N out 70 LI:1188334.1:2000MAY0111 82 forward2 TM N out 70 LI:1188334.1:2000MAY01131 190 forward2 TM N out 70 LI:1188334.1:2000MAY0112 80 forward3 TM N in 70 LI:2188334.1;2000MAY01123 194 forward3 TM N in 71 LI:1188664.1:2000MAY01274 348 forward1 TM N in 71 LI:1188664.1:2000MAY01607 657 forward1 TM N in 71 LI:1188664.1:2000MAY01254 304 forward2 TM N in 71 LI:1188664.1:2000MAY01494 580 forward2 TM N in 72 LI:247388.1:2000MAY011126 1212 forward1 TM N out 72 LI:247388.1:2000MAY01134 220 forward2 TM N in 72 LI:247388.1:2000MAY01389 448 forward2 TM N in Table (cont.) 72 LI:247388.1:2000MAY01968 1033 forward2 TM N in 72 LI:247388.1:2000MAY01741 812 forward3 TM N in 72 LI:247388.1:2000MAY011200 1277 forward3 TM N in 73 LI:816339.4:2000MAY01466 534 forward1 TM N in 73 LI:816339.4:2000MAY01562 648 forward1 TM N in 73 LI:816339.4:2000MAY01937 1017 forward1 TM N in 73 LI:816339.4:2000MAY011162 1248 forward1 TM N in 73 LI:816339.4:2000MAY011306 1368 forward1 TM N in 73 LI:816339.4:2000MAY011390 1452 forward1 TM N in 73 LI;816339.4:2000MAY01407 487 forward2 TM N out 73 LI:816339.4:2000MAY01575 652 forward2 TM N out 73 LI:816339.4:2000MAY01698 784 forward2 TM N out 73 LI:816339.4:2000MAY01950 1012 forward2 TM N out 73 LI:816339.4:2000MAY011043 1105 forward2 TM N out 73 LI:816339.4:2000MAY011136 1198 forward2 TM N out 73 LI:816339.4:2000MAY011244 1306 forward2 TM N out 73 LI:816339.4:2000MAY011334 1396 forward2 TM N out 73 LI:816339.4:2000MAY011424 1486 forward2 TM N out 73 LI:816339.4:2000MAY01468 554 forward3 TM N out 73 LI:816339.4:2000MAY01591 644 forward3 TM N out 73 LI:816339.4:2000MAY01933 1010 forward3 TM N out 73 LI:826339.4:2000MAY011182 2244 forward3 TM N out 73 LI:816339.4:2000MAY011257 1319 forward3 TM N out 74 LI:1188967.1:2000MAY0114 67 forward2 TM N out 74 LI:1188967.1:2000MAY01272 325 forward2 TM N out 75 LI:236230.3:2000MAY021081 1149 forward1 TM N in 75 LI:236230.3:2000MAY011195 1281 forward1 TM N in 75 LI:236230.3:2000MAY011330 2416 forward1 TM N in 75 LI:236230.3:2000MAY01182 253 forward2 TM N out 75 LI:236230.3:2000MAY011016 1102 forward2 TM N out 75 LI:236230.3:2000MAY011154 1240 forward2 TM N out 75 LI:236230.3:2000MAY011346 1432 forward2 TM N out 75 LI:236230.3:2000MAY0163 149 forward3 TM N out 75 LI:236230.3:2000MAY01396 449 forward3 TM N out 75 LI:236230.3:2000MAY01567 644 forward3 TM N out 75 LI:236230.3:2000MAY011107 1181 forward3 TM N out 75 LI:236230.3:2000MAY011320 1382 forward3 TM N out 75 LT:236230.3:2000MAY011410 1472 forward3 TM N out 76 LI:246728.3:2000MAY011633 1695 forward1 TM N out 76 LI:246728.3:2000MAY011783 1854 forward1 TM N out 76 LI:246728.3:2000MAY012492 2566 forward2 TM N out 76 LI:246728.3:2000MAY01792 854 forward3 TM N in 76 LI:246728.3:2000MAY012325 2375 forward3 TM N in 77 LT:1190057.1:2000MAY01646 696 forward1 TM N in 77 LI:1190057.1:2000MAY011195 1263 forward1 TM N in 77 LI:1190057.1:2000MAY011591 1668 forward1 TM N in 77 LI:1190057.1:2000MAY012104 2169 forward1 TM N in 77 LI:1190057.1:2000MAY012233 2295 forward1 TM N in 77 L2:1190057.1:2000MAY012320 2382 forward1 TM N in 77 LI:1190057.1:2000MAY012623 2703 forward1 TM N in 77 LI:1190057.1:2000MAY013124 3207 forward1 TM N in 77 LI:1190057.1:2000MAY011217 1270 forward2 TM N out 77 LI:1190057.1:2000MAY011595 1681 forward2 TM N out 77 LI:1190057.1:2000MAY012267 2353 forward2 TM N out 77 LI:1190057.1:2000MAY012420 2491 forward2 TM N out 77 LI:1190057.1:2000MAY012624 2698 forward2 TM N out 77 LI:1190057.1:2000MAY012720 2785 forward2 TM N out 77 LI:1190057.1:2000MAY013014 3067 forward2 TM N out 77 LT:1190057.1:2000MAY013116 3202 forward2 TM N out 77 LI:1190057.1:2000MZ~Y011905 1991 forward3 TM N in Table (cont.) 77 LI:1190057.1:2000MAY012217 2297 forward3 TM N in 77 L2:1190057.1:2000MAY012601 2657 forward3 TM N in 77 LI:1190057.1:2000MAY013072 3143 forward3 TM N in 78 L2:221836.3:2000MAY01775 846 forward1 TM N out 78 LI:221836.3:2000MAY012050 2106 forward1 TM N out 78 LI:221836.3:2000MAY012197 2265 forward1 TM N out 78 LI:221836.3:2000MAY012539 2613 forward1 TM N out 78 LI:221836.3:2000MAY012216 2302 forward2 TM

78 LI:221836.3:2000MAY012582 2668 forward2 TM

78 LI:221836.3:2000MAY011899 1976 forward3 TM N out 78 LI:221836.3:2000MAY012034 2120 forward3 TM N out 78 LI:221836.3:2000MAY012199 2261 forward3 TM N out 78 LI:221836.3:2000MAY012283 2345 forward3 TM N out 78 LI:221836.3:2000MAY012490 2564 forward3 TM N out 79 LI:334047.3:2000MAY01115 201 forward1 TM N out 79 LI:334047.3:2000MAY0156 142 forward2 TM N in 79 LI:334047.3:2000MAY01497 577 forward2 TM N in ~W-i d~ N CO
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O M M M O r1 M M N r1 01 d~ r1 N Lf1 M LC7 N N M di M M M M ~ L~ M ~ Lf1 dl CO
M CO M l~ 61 w-1 N N N N N N N N N N r-1 N N N N N N N N N N N N N N N N N N N N N N L~ Lt7 In M l0 L(1 1IW -I lf7 00 O O O M ~ N v-I N Lfl In M N dl 00 Lfl Ol M M Lll O dl M c-I c-I Lfl CO ~ O1 N M LC1 L17 l0 M M OO 01 01 N Lf1 LC1 l0 lD M M L~ 00 d1 N M I-(l L~ M
l0 L~ O~ 01 O lO N l~
L~ L~ l~ CO 00 CO ~ 00 ~ M 00 00 CO 01 01 01 01 41 01 O O O O c-1 c-I c-I w-I
N N N N N M Lf'1 L~ 00 c-I
r-1 c-I c-I c-I w-I v-i v-I w1 u-I c-I u-1 v-1 c-I i-1 i-1 r1 v-1 c-1 ci N N N
N N N N N N N N N N N Ll7 M M Lf7 v-I
r1 r-1 c-I W -1 c~ c-I r-I
~ a xxH~xx~~ xxxx~wxO Nox ~n~ ~x xx~x~x N ~ 01 M 00 O LI1 L~ 01 l0 h N dl di N H CO M O l0 00 O lD L~ lW -I O c-I M d~
l0 61 l0 ,'1', l0 c-I l0 N
01 111 L~ dl t-I L~ N o0 dl N v-1 dl 61 u-1 O 00 ~ N 01 c0 a0 l0 L r1 v-I d~ N
O l0 M O LC1 l0 L~ O l~ L(1 O
r1 ~ dl to 01 O .O l0 l0 M O O LC7 l0 61 l~ CO N c-I M l0 l~ LW -I L~ In ~ Lf7 l~ N d~ O di OO t~ O 01 Lcl dl N M M In O dl M l0 O N N ~ ~ I-(7 l0 L~ L~ Ol ~O ~-I dl dl di M M M M M L~
M L~ 00 ~N M O 111 M
N dl M 01 O c-I O 01 L~ L~ 01 LI1 v-I O I~ O l0 l0 01 CH 01 01 01 N d~ 61 01 N
01 O N dl O O ~ O LC1 L(1 01 N 00 O N LW -I O 00 Lf7 L~ N Ol M L~ O N N w-I 01 e0 O O Lf1 01 O O 01 O N
CO L~ r1 Lll 01 N OO 01 LC7 LW -I L~ Lc~ dl L~ L~ b1 b1 t51 L~ 1.I~ dl l11 O1 v-I w-1 b1 b1 b1 l~ l~ N
X31 L~ L~ L71 L~ lf7 b1 lD 111 L~ 10 b1 l0 b1 l0 Lf7 01 N N l0 L~ L~ l0 l0 CO M CO 01 dl 00 dl ~ M M l0 c-I M v-1 l0 l11 c-I
N Lfl N lf7 CO M 61 l0 Lfl -I r1 d1 Ll7 M N N N M ~-I L t N O1 M tf1 'dl dl CD N M ~ O M O 00 L r1 c-I c-I ~N ~
l0 01 01 l0 ~-1 C~ dl dl v-I O1 v-I N M N N M N N M l0 v-1 l0 lD l0 L~ l0 L~ L~ a0 M ~ 00 00 N M O 01 M N M M M M M M M M M w-I ~-I c-I i-1 c-I c-I c-I r1 r1 v-I v-1 v--I r1 r1 N N
N c-I r1 N N v-I N N N N N
v-I v-I M l0 l0 l~ dl LI7 O N d~ c-I l0 N L~ O l~ O 01 r1 dW -1 Lll l0 l0 M
LC1 lO d~ O L(1 01 00 v-I c-I l~ 01 ~ 00 h 01 O N 111 Ill N d~ 61 lD r1 O M l~ r1 LC1 l0 L~ 01 N l0 v-I v-i d~ to l0 lD O d~ dl Lll 01 l~ l~ L~ L~
p L~ L~ ~ ~ O1 61 01 O r1 v-I w1 N O O O O r1 u--I c-I v-I v-I N N l0 l0 l0 l0 l0 lD L~ L~ L~ L~ L~ L~ L~ L~ L~
N N N N N N N M M M M v-I O1 u-I u-I v--1 c-I u--1 c-I c-I w-I v-I w-I r1 r1 v-I w1 u-1 c-1 v--I r1 c-I v-1 c-1 c-I r1 u--I w-I
N
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LIl Lfl Ol v-I M v-I Ol 01 l0 L~
v-I w1 tIl N 00 L(1 OO C~ N 00 N l0 lO lO 'd~ CO O 01 r1 OO lf1 N r-I N lO O M
O Lf1 O l0 O lf1 M L~ L~ L(1 M
N N O N l0 d~ N N M r-I r1 I~ L~ N 01 l~ 01 Q1 O N N v-1 CO 00 LCl LW -I O M ~
N r1 01 01 d~ dl di O
r1 v-I M M 00 c-I L~ <H W -1 c-I d~ O d~ M O M M d~ ~ dl dl M d1 L~ M d~ I~ d~
Le7 M dl d~ t~ M M c-I N
M M dl LW -I l0 c-I N h C~ N c-1 d~ O O 01 O O O O O O 01 L~ l0 Ol O d~ M O l0 O Lfl O M M I~ M
M M O l0 dWf7 00 w-I l0 l0 M di O u--I r1 N c-I r1 v-I c-1 c-1 r1 O II7 h O v-I 01 M l~ LW -1 N IP O~ N N M
M M N t51 ~1 b1 ~Sl X31 iT ~1 tn r-1 L~ L~ L~ L~ L~ l~ I~ l~ L~ L~ L~ iT ~1 L~
h X71 M ~Sl l0 [W -I 10 v-1 c-1 10 M
LC7 N O1 O1 O1 O N Ll7 d~ d~ L~ Lf1 ~ M Lf7 N M N L~ N ~ N l0 L~ In l~ M N M
l0 O N ~ Ll7 L~ ~O lD 00 L~ l~ OD 10 l0 ~ l0 l0 l0 Lf1 Lf1 L(1 l0 L~ 1f7 l~ M 01 O O M O 00 u--I OD l0 l0 'dl 00 M II7 l~ l~ N LCl O l~ dl M l0 N l0 l0 l0 dl l0 lD l0 ~H dl l0 10 lD M Lf1 O 00 l0 01 00 l0 L~ O CO r1 v-I v-I ~ N M N N O O N O
N N N N N N N N N N N N N N N N N M N N N N N N M N M M M N M M M M M M M M
dl dl L~ Q1 O O l0 N r-1 N 00 OJ l0 117 ~ C~ d~ M M M M M N M L~ N CO L~ M O
l0 ~D LW -I M dl 01 OO
~ L~ L~ L~ 01 01 00 01 01 O O O u-I N N N M v-I v-1 v-i M M M M to L~ OO 01 v-I M W -I M lO \fl lD L~ L~
r1 u-I v-I r1 v-I w-I v-1 c-i w-I N N N N N N N dl II1 tf1 t11 Ll1 tI1 Ll7 t11 Ll1 111 L(7 117 l0 l0 lO L~ L~ l~ L~ t~ L~ L~
N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N
c-I r1 c-I r1 r1 v-I c1 ,W o ~ ,-~ r ~ ~ ~ c-i ,-I ~o ,--W-I ~o ,-~ ,~ r-I N c-i ~ ,--W o ,-i r-I yo ~
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O1 Lh dl L~ N o0 x O O1 l0 C~ l0 00 Ol l0 ~H M M Ill L~ 01 L~ M c-1 1-(7 O!) M M N v-I lfl N c-I N O
00 l0 w-I N M N l0 lIl dl dl r1 M
l0 dl O Lf1 Ln N v-1 dl N cW -i O r1 L~ 01 l0 c-I O O CO u-I r1 LW -I 61 M 10 d~ c-I L~ h l0 L~ 00 N ~ N O
M M M L~ O 01 L~ N 01 01 M M Ol wl 00 N l0 01 01 ~ cr L~ t11 d~ d~ 01 M 01 dl d~ L~ M dl l0 w-1 M r1 N
d~ L M r1 L~ O r-I d~ O O O O O M O' 01 00 N N N O dl d~ O L M 01 If1 O N L(1 OW -I l~ N Ol M d~
Lf1 M c-I d~ N O O c-I O O N N O c-I O Ln M 01 01 01 dl N OO dl N CO O LC7 d~
dl tf1 O d~ Lf7 c-I LC1 M Ol r1 b1 N b1 ~1 L~ l0 b1 L~ L~ 01 01 L~ ~S7 LW H t11 Lf1 L(7 111 N N L(1 N lD d~
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d~ N N 111 01 00 L~ In N In 01 v-I ~O L~ lO O dl M L~ M N lO N M N N M CO c-I
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O dl L~ 00 00 c-I CO
N L~ l~ ~1 X31 ~1 b1 b1 L~ N l0 ~1 l~ l~ l~ L~ c-I LCl In Lll L!1 h t1'1 Lfl L~ L~ ttl L~ L~ ~7 L~ L~ l0 M N N C~ l0 ~ ~ M ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ M
c-I w-I dl O N W -I 0~ N N dl d~ d~ r1 01 v-1 61 01 M ~ M O1 N O r-I M r-I
d~ 01 dl L~ c-I 00 l0 LC7 Lf7 M Ll7 l~ O l0 O d~ l0 M 01 In L~ dW -i M dl CO
00 M h M L!1 CO dW -I d~ c-I l~ 61 l~ lO L~ l0 00 L~ L~ LI7 M M N l0 w-I O O O1 L~ O 01 M 'd~ L~ l0 ~N l0 L~ l0 dl M 01 01 01 01 CO v-1 d~ 01 N
N N N c-I c-1 ~-1 ~-I N r-I ~-I r-I r-I N N N ~-I r1 N r1 r1 ~-1 ~-I N N N N N
d~ CO L~ 01 L~ L~ r ~I ~O of of CO 00 00 M L~ CO LCW -i N l0 M M l0 l0 l0 l0 l0 00 00 w-I CO l0 L~ M l~ O
L~ L~ L~ O N L~ ~ dl L~ CO r1 N h L~ L~ L~ L~ L~ L~ O l0 00 01 lD 61 LC1 d~ N
Ll1 Lc'1 lD N N N Lf1 M C~ N
p M M M 1I7 Lt1 d~ di N O O O ~ dl d~ dl d~ d~ dW N r1 u-I N N N N N N r1 L~
L~ M d~ d~ N N CO Ol N
U N N N v-I u--1 c-i w-1 N c-I w-I v-I c-I v-I v-I v-I ~-I c-1 r1 r1 r1 c-I u--I N N N N w1 N M Il1 L~ 111 tll tll lIl M d~ Lf1 N
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61 01 Ol l0 d~ l0 Lf1 ~ 00 00 OJ O M 00 ~ h M M l0 L11 O M l0 CO d~ ~ I~ M M O
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LI1 01 M l0 CO LI1 L(1 l~ M l0 L(1 C
O O O 01 LP1 c-I 10 01 dW -1 CO 01 tf1 CO ~ 01 Lf1 L~ c-I t11 N 01 10 M II) l0 M L~ 01 M l~ l0 l0 O 61 d~ Lh O
N N N Lf1 O 00 dW -I d~ M l0 l0 L~ N N O1 L~ c-I 0~ O r1 OJ l0 M ~O Ol d~ d~ c-I M c-I M M lO u-1 O M ~O
~ 00 00 00 u-I 00 LC) N O L~ 1~ ~ r1 v-I v-I O r1 O 00 dl N L~ M 01 00 O ~ d~
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01 O1 O1 dl b1 N d~ l0 Lf7 Lf1 N LC7 dl L~ L~ LW N t~ N c-I l0 l0 b1 d~ b1 t~
lO Ln l0 O N r-I c-I N lO r1 l0 N
~ ~ M
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d~ N M ~ L~ M 01 dl 01 N L~ ~ N O LC7 l0 v-I dl M v-1 N l0 N \D l0 I~ d~ ~-I
Ol O L~ 01 LCl 01 00 t11 L~ c-1 M l0 O 00 M LC7 l~ LW -i c-1 O LC7 L~ N Ol L(1 N l0 N O 00 OD W
v-I O M l0 01 r1 M O l~ LCl 00 M CO dl Ill l0 LC1 LC7 Ln ~ 00 L!1 l0 Ill O 01 L~ ~ L~ ~ O O L~ L~ N L~ O c-I
01 c-I r1 N ~H r1 M O dl l~ O
N dl N N N N w-I v-I c-I v--I w-I c-I ~-i N r1 v-I w1 c-1 w1 N N r1 r1 N v-I N
N v-I c-1 r-I c-i a0 v-I a0 v-I LW -I N
Ill -I M 01 v-I c-I ~ l0 r1 00 O O l0 d~ OD c-I L~ M M dl ~O O L~ O d~ Lf1 l0 ~
M d~ 00 N l0 l~ l~ L~ c-1 c-1 N l~ l0 OW -l dl '<H l0 l0 O~ 01 LC1 LC) 01 c-i c-I dl l0 L(1 L(1 l0 <N O M rI -1 L~ M M M 'cH N N N N M M M M M M dl d~ dl dl dl dl d~ Lf1 Lf1 Lf1 l0 l0 v-i OO
Ol Ol Ol L~ L(1 00 l0 lfl v-i N N N N N v--I v-I u-I c-1 c-I c-1 c-I r1 v-I v-i v-I u-1 c-1 v-I w-I r1 v-I c-1 w-I c-I c-I c-I 00 l~ L~ l~ L~ L(1 L~ M c-I r1 ~ ~ ~ ~ ~ ~ ~ ~ 5 ~ ~
d~ x x ~o x M x ~O o ~-I N N x m x M ~o ~-I x x N 01 x x ~-1 ~ ~--i x G4 x ~
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u-I 00 O N l0 c-I L~ O 01 v-1 d~ L(7 dl N l0 L~ O O ~ r1 O ~ L(1 l0 M l0 dl l0 w-I dl ~ OO Lf1 N ~ l0 di Ll7 M 01 c-I d~ N dl d~ 01 M dl N dW -I d~ L~ l!1 di 117 M dl d~ ~ Ll1 M d~ di O
d1 N d~ Lf1 LIl 01 N N dl ~ N
M Ll1 tf7 01 Ill O1 c-I l0 O O c-I ~ 61 O M O O 01 01 O O L~ N Ol N N l0 CO O
L~ N N C~ N L~ O L(1 N
N M M O v-I O dl [~ c-I r-1 1p O 00 r1 d~ L~ c-I l0 O v-I c-I v-I 1l1 O c-I c-1 LC) M l0 L~ lO lO ~ O LC1 Lfl N v-I
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v-I M dl dl O 00 l0 M LCl N M d~ lIl l0 L~ l0 M N N M L~ t51 L7> ~l l0 d~ M lf1 ~ 00 CO ~ O~ CO 00 OD 00 00 ~ 01 Ol Q1 dl N M l0 O L~ O r-I l0 M Ill -1 M O dl ~ N 01 M r1 M ~ dl l0 Ill N O M l0 v-1 N O N ~ dl Ill O
l~ 00 01 00 [~ O 00 01 l0 CO OD v-I N ~D M ~ d~ d~ l~ c-1 LW -I 01 N v-I O~ O
di dl C~ O O O O ~ M L(1 dl M l~ L~ L~ L~ N I~ L~ l0 L~ L~ M t~ di di M d~ M N 01 01 M M M M 01 O N N c-I
c-I N <-I ~-I dl M L~ L~
N N N c-i N N N N N N N N N N N N N N wi ~ N N N N r1 N N N N N N N N N N N N
L(1 l~ M l0 M N v-I ~ ~ 01 L~ L~ dl dl ~ dl 'cN 01 00 Lll L~ l0 L(> 61 61 dl 00 00 00 01 tll N Ln c-I OW -I v-I
61 O O c-I W-I OO l0 L~ d~ LI1 dW -I Ill lIl l0 L~ L~ l0 t~ 01 O d~ di d~ d~
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L~ 01 01 01 01 00 01 01 00 N N N
c-I N N N u-I ~-I N N N N N N N N N N N N c-I w-I v-I w-I ~-1 r-I v-I v-I v-1 r1 r-I v-I r-I w-I u-I r-I v-I N N N
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II) 01 ~ l0 M M r1 Ln ~ L~ tll dl N M M r-I L~ h v-i L(1 M O r1 O ~ O~ O O dl L~ l0 dl 01 lCl CO 01 O 00 L~ to ~ dl N OO CO CO O O O 01 CO 01 01 M l0 l0 N Ll1 l0 Lf1 LCW -I N N O O 01 01 01 fW -I dl l0 l0 lO N
l0 d1 O M l0 OO ~ L(1 IS1 00 O O OJ l0 l0 c-1 OJ 00 l~ 01 L~ N N l0 N N LC1 L~
O1 ~ 'dl dl L~ (~'> L11 00 d~ N
r1 00 L!7 01 M N N ~ c-1 N 01 00 N Lf7 in d~ 01 01 w-1 ~1 N N N 01 01 O1 O 00 OO 00 00 f~1 N ~0 00 O O 01 N M r1 M v-I c-I w1 O 00 M dl Lc'7 r1 O O l0 N N O l0 O r-I r1 O l0 l0 M a0 00 OO CO N L~ O O dl L11 l0 L~ X51 b1 t51 L C~ L~ l~ O1 b1 b1 a0 L N N c-I w-I v-1 L~ Lfl L~ L~ L LW -1 v-I v-I Ill Ll1 LI7 Ill b1 N N L~ N c-I c-I
~ O ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ W M
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SEQ
Table 3 ID NO: Tissue Distribution 1 Unclassified/Mixed - 71%, Endocrine System - 16%
2 Embryonic Structures - 82%, Nervous System - 18%
3 Germ Cells - 62%, Connective Tissue - 17%, Unclassified/Mixed -4 Endocrine System - 71%, Nervous System - 29%
Nervous System - 76%, Endocrine System - 18%
6 Endocrine System - 63%, Liver - 23%
7 Endocrine System - 29%, Hemic and Immune System - 24%, Exocrine Glands - 19%
8 Endocrine System - 42%, Germ Cells - 19%
9 Endocrine System - 66%, Sense Organs - 21%, Nervous System - 11%
Germ Cells - 30%, Sense Organs - 24%, Nervous System - 17%
11 Nervous System - 100%
12 Embryonic Structures - 18%, Pancreas - 17%, Hemic and Immune System - 17% ' 13 Exocrine Glands - 42%, Cardiovascular System - 21%, Respiratory System - 16%
14 Nervous System - 86%
Unclassified/Mixed - 17%, Sense Organs - 12%
16 Unclassified/Mixed - 28%, Embryonic Structures - 20%, Liver - 16%
17 Endocrine System - 100%
18 Digestive System - 57%, Hemic and Immune System - 29%, Nervous System - 14%
19 Unclassified/Mixed - 90%
Exocrine Glands - 50%, Respiratory System - 38%, Nervous System -21 Unclassified/Mixed - 20%, Connective Tissue - 10%
22 Sense Organs - 17%
23 Female Genitalia - 32%, Hemic and Immune System - 24%, Endocrine System - 20%
24 Sense Organs - 15%, Embryonic Structures - 13%
Sense Organs - 43%, Unclassified/Mixed - 11%
26 Unclassified/Mixed - 16%, Embryonic Structures - 13%, Germ Cells -13%
27 Respiratory'System - 43%, Nervous System - 21%, Female Genitalia -28 Liver - 33%, Germ Cells - 12%
29 Endocrine System - 31%, Germ Cells - 25%, Liver - 12%
Exocrine Glands - 29%, Germ Cells - 28%
31 Exocrine Glands - 18%, Cardiovascular System - 10%
32 Sense Organs - 23%, Embryonic Structures - 15%, Endocrine System -33 Sense Organs - 17%, Endocrine System - 11%, Skin - 10%
34 Musculoskeletal System - 86%
35 Connective Tissue - 16%, Embryonic Structures - 14%, Digestive System - 11%
36 Pancreas - 40%, Female Genitalia - 20%, Cardiovascular System -37 Respiratory System - 12%, Urinary Tract - 12%
38 Embryonic Structures - 53%, Digestive System - 17%, Nervous System - 12%
39 Digestive System - 40%, Nervous System - 32%, Nervous System - 28%
40 Exocrine Glands - 47%, Sense Organs - 21%
41 Connective Tissue - 60%, Unclassified/Mixed - 22%
42 Hemic and Immune System - 15%
43 Sense Organs - 21%, Female Genitalia - 13%
44 Hemic and Immune System - 18%, Female Genitalia - 17%
45 Embryonic Structures - 32%, Female Genitalia - 17%
46 Male Genitalia - 49%, Skin - 32%
47 Nervous System - 42%, Nervous System - 40%, Endocrine System - 14%
48 Digestive System - 41%, Nervous System - 15%, Liver - 14%
49 Exocrine Glands - 34%, Unclassified/Mixed - 22%
50 Nervous System - 57%, Unclassified/Mixed - 11%
51 Nervous System - 52%, Digestive System - 25%, Connective Tissue -52 Digestive System - 24%, Germ Cells - 22%, Exocrine Glands - 11%

Table 3 (cont.) 53 Endocrine System - 32%, Digestive System - 19%
54 Embryonic Structures - 58%, Nervous System - 37%
55 Female Genitalia - 18%, Nervous System - 18%, Embryonic Structures - 18%
56 Connective Tissue - 29%, Germ Cells - 22%, Liver - 13%
57 Musculoskeletal System - 15%, Embryonic Structures - 11%
58 Stomatognathic System - 27%, Urinary Tract - 11%
59 Sense Organs - 25%, Endocrine System - 16%
60 Exocrine Glands - 33%, Urinary Tract - 27%, Nervous System - 14%
61 Endocrine System - 16%, Musculoskeletal System - 13%
62 Exocrine Glands - 27%, Skin - 15%, Female Genitalia - 15%
63 Female Genitalia - 36%, Urinary Tract - 22%, Digestive System -64 Germ Cells - 16%, Endocrine System - 11%, Liver - 11%
65 Pancreas - 24%, Unclassif~ed/Mixed - 21%, Male Genitalia - 17%
66 Endocrine System - 43%, Embryonic Structures - 14%, Unclassified/Mixed - 12%
67 Embryonic Structures - 42%, Male Genitalia - 19%, Female Genitalia - 19%
68 Male Genitalia - 67%, Nervous System - 33%
69 Urinary Tract - 50%, Endocrine System - 18%
70 Respiratory System - 100%
71 Skin - 43%, Nervous System - 19%, Nervous System - 19%
72 Cardiovascular System - 35%, Nervous System - 27%, Male Genitalia - 19%
73 Female Genitalia - 12%, Germ Cells - 11%
74 Male Genitalia - 28%
75 Embryonic Structures - 30%, Urinary Tract - 22%, Respiratory System - 16%
76 Musculoskeletal System - 16%, Respiratory System - 12%
77 Nervous System - 35%, Male Genitalia - 31%, Germ Cells - 11%
78 Stomatognathic System - 19%, Liver - 12%, Exocrine Glands - 11%
79 Respiratory System - 38%, Female Genitalia - 38%, Male Genitalia -2 5, %

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<110> INCYTE GENOMICS, INC.
PANZER, Scott R.
SPIRO, Peter A.
BANVILLE, Steven C.
SHAH, Purvi CHALUP, Michael S.
CHANG, Simon C.
CHEN, Alice D'SA, Steven A.
AMSHEY, Stefan DAHL, Christopher R.
DAM, Tam C.
DANIELS, Susan E.
DUFOUR, Gerard E.
FLORES, Vincent FONG, Willy T.
GREENAWALT, Lila B.
HILLMAN, Jennifer L.
JONES, Anissa L.
LIU, Tommy F.
ROSEBERRY, Ann M.
ROSEN, Bruce H.
RUSSO, Frank D.
STOCKDREHER, Theresa K.
DAFFO, Abel WRIGHT, Rachel J.
YAP, Pierre E..
YU, Jlmmy Y.
BRADLEY, Diana L.
BRATCHER, Shawn R.
CHEN, Wensheng COHEN, Howard J.
HODGSON, David M.
LINCOLN, Stephen E.
<120> SECRETORY MOLECULES
<130> PT-1134 PCT
<140> To Be Assigned <141> Herewith <150> 60/185,215; 60/185,216; 60/205,232; 60/205,323; 60/205,287;
60/205,324; 60/205,286 <151> 2000-02-24; 2000-02-24; 2000-05-16; 2000-05-17; 2000-05-17;
2000-05-17; 2000-05-17 <160> 159 <170> PERL Program <210> 1 <211> 608 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:223939.1:2000FEB18 <400> 1 gtgaaataat ggaattagtc ctggtgaaat accagggcaa aaactggaat ggacatttcc 60 gcatacgtga tacactacca gaattctttc ctgtgtgttt ttcttctgac tccacagaag 120 tgacgacagt cgacctgtca gtccacgtca ggagaattgg cagccggatg gtgctgtctg 180 tctttagtcc ctattggtta atcaacaaga ctacccgggt tctccagtat cgttcagaag 240 atattcatgt gaaacatcca gctgatttca gggatattat tttattttct ttcaagaaga 300 agaacatttt tactaaaaat aaggtacaat taaaaatttc aaccagtgcc tggtccagta 360 gtttctcatt ggatacagtg ggaagttatg ggtgtgtgaa gtgtcctgcc aacaatatgg 420 agtacctggt tggtgttagc atcaaaatga gcagtttcaa cctttcacga atagttaccc 480 tgactccctt ttgtaccatt gcaaacaagt catcattaga actagaagtt ggcgagattg 540 catctgatgg ctcaatgcca actaataaat ggaactatat tgcttcttca gagtgccttc 600 cattttgg 608 <210> 2 <211> 755 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:397140.1:2000FEB18 <400> 2 tatggaaatg cactttatat ttatttgcac acatcaagaa tacttttgga aaccaggatt 60 tagaaaaata aaagatattt ctttcctggg gacaaagtga cctgcaaatg attggcttct 120 gtacaatgtt gcaatccctt aatgtcagac tcttaggaaa atgggtggga catctgtgtg 180 tttgtgttgg agtgaatgtg cccataaccc tgtgctccca taagtctgtg tgcccgtgat 240 catatgcata tgggtgaatg tttgtgtgcc catgatttta tgcatatagg tgaatatttg 300 tgtgcccatg agcatatgca tatgggtgaa tgtttgtgtg cccatgagta tatgcatacg 360 ggtgaatgtt tgtgtgccca tgagtatatg catatgggta tatgtttgtg tgcccgtgat 420 tatatgcata tgggtgaatg tttgtgtgcc cgtgattata tgcatgtggg tgaatgttca 480 tgaacaaaca ggtacactcg gagtagaaaa caaatgaagc aaaagtttag catcctctca 540 tgtgtgtcaa cattgtagtt ttacatgtac tttcttctaa tctattaaac ataagtatgg 600 ctccattttt ttagtattac cagaagccct cccaatacgg caatattacc ttctgtgtaa 660 tccacttgcc gacagcatgt tttctgttga aatgggacat caagaatttt gaatccaagg,720 ccatatgctg catgctcatg atttacaatg gtttg 755 <210> 3 <211> 1078 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1094205.1:2000FEB18 <400> 3 ctcccaagat ggcggctcct ccgggcgagt acttcagcgt tgggagccag gtgtcgtgcc 60 ggacgtgcca ggagcagcgg ctgcagggcg aggtggtagc ctttgactac caatccaaaa 120 tgctggcttt aaaatgtccc tcttccagtg gaaagcccaa ccatgcagac atcttgctca 180 taaacttaca gtatgtttca gaagtggaaa taattaatga ccgaacagaa acccctcctc 240 ccctagcttc actcaatgtt agtaagcttg ccagcaaagc acggacagag aaggaggaga 300 agctgagcca ggcctatgca atcagtgctg gtgtctctct agagggccag cagctcttcc 360 agaccattca caagaccatt aaagactgta aatggcaaga aaaaaacatc gtagtcatgg 420 aagaagttgt tattacaccc ccatatcaag tggaaaactg taaaggcaaa gaggggagtg 480 cactgagcca tgtacgcaaa atagttgaaa aacattttag agacgtggaa agccaaaaga 540 tactgcaacg ttcacaagcc cagcaaccac agaaggaggc tgccctgtca tcctgagtcc 600 gtacacatgg aggactcttc cagcatccag ccaaggaggc gctggtggtg gcttcagcgg 660 aggcaggccg ggggagggaa gggatcctat atgtcctgtt ggctcttaac aaagggtcag 720 catttccaac tcttagactt gaacaaacaa aacacccaac aaaaaagaac aagagaataa 780 tttaaaagtt gaatcattac ttgactaaca gacttcggtc caccatgtcc ttttcacagc 840 cctcttctgg aacagtcacc ttggtaattt tattttggaa aattattttc ccactctgcc 900 ctttacttct gactttcctt tcctagattg ttcctgccat tctgtgttta taagtggcta 960 cacttgcctt ctgaatgatt gaaagaaact tttacatctt ttcttccaaa ataaaagtaa 1020 caagctgact gtgattctta aattgagacc agagcagcaa acgtctcact ttaaattt 1078 <210> 4 <211> 533 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:481361.5:2000FEB18 <400> 4 gttcttttcc ccttttctcc agagataaat gtgttgatct taaacatttg cttctgtgag 60 aagctccagc acctgtgtgt cactgtcatc gagatcagta ggctgtttga tggtgatgaa 120 gatggtggcc tccttactca gaatgctttt ttctcatttc ctagtgggat tttagtgtgc 180 actgatgtga tggcccgggg aattgatatt cctgaagtca actgggtttt gcagtatgac 240 cctcccagca atgcaaggta tggtacgagg ctgccaccca ctctctgttg aggaatttag 300 ccaccacatg tgaaaattac aattactttc ttcaaagtca gcatatattc ctaatacatg 360 cttccacgca taggaaaatg cctataaacc cccaagtgtt gatgattact cctgaggtta 420 ttggtcattt tcattttatt ctttgtattt ttcattgttt cccagatttt ccactgggga 480 ctatgtccca cctgtatgat cagagagaaa gatacaagtt atacttaaga gta 533 <210> 5 <211> 2149 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:981170.1:2000FEB18 <400> 5 aatttttgac tttctccttt gtaattaatc tctatctggg tttctctctt tctctgtgcc 60 atttggtttc cttaattagt tccctgtgcc agcccatagt cagagccata attggctctg 120 gggaagatcc aagttatttt ctgagtaaga tattaggctt ccatatgatc cagagatgca 180 aagaaatccc tagagagtgt aggagttgtc taaatccatg tgtcagatgt agccaacgaa 240 ttatgtcaga agcagagaga aaaggcctga aaagcagctc tctcccactc ctcaggccct 300 tgtctccaac cttacatgag gctttttgaa catctcctcc tggcccagct ggggtgagag 360 caagtcctcg aaggcactgc ctttgagcct tgctcagccc atctgaacta tcccaactct 420 agaattgact gctttcgaat tgtgtgacct tgggaatgtt atctggcttc aaccacaatg 480 ccctaccccc agctcctctc ccaaatgatc ctagatacag ggctgcttcc ccccgaccct 540 accccacctc gggacacagg ctcatggcct catggcactt caccaccaga agtggtgctc 600 agagttccta tttccacatc taacccccta attcctggga aagtctgagg cctggtcccc 660 ccagtgcttt ccctggctgg cctctccaca ttttcatctg atggtggagt gagatcagga 720 aaaataggac aggagctttg ccttggggga gaagagagtt aagtgtggaa aggggtgagt 780 tataggaggt taagcagtcc aagatttctc tctctgtgta ggaggccatt tcctgatgtg 840 aggggtctga acccaattat gatgggacag ggttgggcat tgacttccca tctcttctct 900 ctgtttttct cccactatct gtagcccaaa actcttatgg aggactttga tctttagtat 960 aggctattgg tcagggccat aggaactaac cccgatcctc actccaccag gatctaccac 1020 atcccctaca cacaaacaca tgctgtgggg agggagtttt cccctgggtc aagttgagga 1080 tccttagatc accttgtgct cctgtggact ggtgtgtgcg tgtgtgtgtg tgtgtgtgtg 1140 tgtgtgtgtg tgtgtgtgtg tatgtgggga aacttagctt tcagagaatg tctatgggct 1200 ctcattttct ctctcacaca aaaatactcg ggacttctcc aagtccctga ggagcctgac 1260 cactgaagct gatcatgaga tgactgtatg ctgacacacc cccttcaggg gcctggcctt 1320 gacttagggc tgcactgtat cctcagcaac ggccttgcag gagccccttt tggactgctt 1380 tccctattca gCCCagagtt ggggtggtgg gagaagaggg gttggagtga atccatctct 1440 attcaaattc cagctgggat tactctagga gtcttcctgg cttgttttgg gctcaaactt 1500 agctacattg tttattggct cccaaagtcg ggattgaaga gtgaaaagat gcaggcaatg 1560 aatccttctg cacactcctc cccaaccttt ccagcgcttt tctacttagg aggccagtgg 1620 aagggaggag aggccatgcc ctagcccaca ggggacaagg ttcattgttc ttccaggctt 1680 ggttcactct gcttttgatt cagaagctct ttccctaccc agcaagacta cactttcttg 1740 ccttctttct attttttctt tttgtgcgta taaatggtat gttgtgatat attctcagtg 1800 cttgtgccca ccttggaact ctgttcttgc tcttcattcc gcatgtgata ctctggtcca 1860 agatcttggc caggtgcctt ctgctcaaat atcgtctcag aggtgcttcc cttgaaaact 1920 cggtgctgtt tccatagtta ctctatttga tcactctaag tttggttgtc ttcatagcac 1980 ttgtcaccct ctggaactat tctattcatt tatttacttg tttaatgctt ggctcttttc 2040 ccctcctaac gtaaactcca tgattgccaa cacctgttta cttactacag ttccccctcc 2100 ccccacattc ctgacactag taagaaccaa taaacacttg ttgacggaa 2149 <210> 6 <211> 669 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:197613.1:2000FEB01 <400> 6 tgcatcctct gggcacgctc cacttgccgc ttccacccgg aaagcccccc aggctgagtg 60 cggcatgatc tccatcaccg aatggcagaa gattggtgtg gggatcaccg gtttcggcat 120 cttcttcatc ctctttggaa cactcctgta ctttgattcc gtgctcctgg cctttggaaa 180 cctgctgttc ctgacgggcc tgtccctcat cattggcctg aggaagacct tttggttctt 240 cttccaacgg cacaaactca agggaaccag cttcctcctg gggggtgtgg ttatcgtgct 300 cctacgctgg cccctcctcg gcatgttcct ggaaacctac ggattcttca gcctctttaa 360 ctgttccgga gacttcaagg cactagctcg atggtctgaa aaacagagat gagctccttg 420 aacttggatc attggttgag ggggctagag ggagaatggg aaccaccccc tcagtcccct 480 gcactgactc actccccgac atatccggac ctccccaagt ccagaaggaa ggaatggagc 540 tgagcaactg acgtcaaatc cccaagtcga ctcaagaggc tgccaggaag cagagatgca 600 gaccccaagg agactgggct ggggctggta tcacaccctc acacgcacaa cttggggtct 660 cgagtctag <210> 7 <211> 463 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:902682.1:2000FEB01 <400> 7 taagtaatga ggagccaaat gctaatcacc aaagcaatgg ggaaaatgtc tccagggcat 60 gtcagagacc ttcacagcag cctctcccat cataggcctg gagacctagg acagaaaaat 120 ggtttcctag gctgctgcta ttctgtgcag tgtcagaaca tgttcgcctg tgtcccagtg 180 acttcagctt cagctgtggg ctgaaagagg ccaaggcaca gctcagaccc ttgcttctaa 240 gggtgtaaac cctaagcctt gcagtttccc acatggtgtt tggcctgttg gtgcatagaa 300 gtcaaaaatc gaggtttgag aacctccacc tagatttcgg aggatgtatg gaaatgcctg 360 gatatccagg cagaattttg ctggagaggc agagccctaa cagagaacct ctgctaaggc 420 agtgcagaag ggaaatgttg,ggtcagaact cccaggcaga gtc 463 <210> 8 <211> 2271 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:212029.1:2000FEB01 <220>
<221> unsure <222> 54, 1164, 2259 <223> a, t, c, g, or other <400> 8 ctaccctgct cctcagcctg tgagaacaga tgtggccgtc ctgcggtacc agcnaccccc 60 tgagtatggg gtaacgagcc gcccatgcca acttccgttc ccatcaacca tgcagcagca 120 cagccccatg tcctcccaga cctcttccgc cagcgggcca ctgcactctg tctccctgcc 180 gcttccactc ccgatggccc tgggtgctcc acagcccccg cctgccgcct cccccagcca 240 gcagcttggt ccagatgcct ttgcgattgt ggagcgagcc cagcaaatgg tggagatatt 300 aacagaggag aaccgggtgc ttcaccagga acttcagggt tactacgaca atgccgacaa 360 gctccacaag tttgaaaaag aacttcagag aatttcggaa gcctatgaaa gtctggtcaa 420 gtctaccacc aagcgagaat cgctggacaa ggccatgaga aacaaattgg aaggcgagat 480 tagaagactt catgatttca acagagacct ccgagatcga ctagagactg ctaacaggca 540 actatccagc agggaatacg aagggcatga agacaaagct gcagaggggc attatgcttc 600 ccagaacaaa gaattcttga aggaaaagga gaaattagaa atggagttag cagcagtgcg 660 gactgcaagt gaggaccatc ggagacacat cgagatcctg gaccaggctt tgagcaacgc 720 ccaggccagg gtcatcaagc tggaagagga gttacgagag aagcaagcat atgttgagaa 780 agttgagaag ctgcagcagg ccctgaccca gctgcagtct gcatgtgaga agcgagaaca 840 gatggagcgg agactgcgga cttggctgga gagagagctg gatgcactga gaacccagca 900 gaaacatgga aatggccagc cagccaacat gccggaatac aatgccccag ccctcctgga 960 acttgtgcgg gagaaggagg agcggatcct ggccctggag gccgacatga caaagtggga 1020 gcagaagtac ctggaggaga gcaccatccg acactttgcc atgaatgccg cagccactgc 1080 agcagctgag agggacacca cgatcatcaa ccactcacgg aatggcagct acggagagag 1140 ctcgctggag gcccacatct ggcnagagga ggaggaggtg gtgcaggcca acagaaggtg 1200 tcaggacatg gaatacacta ttaaaaatct ccatgccaaa atcatagaga aagatgctat 1260 gattaaggtc ctgcagcagc gatctcgtaa agatgccggg aagacagact cctccagcct 1320 acgtcctgcc cgctccgttc catccatagc agcagctact gggacacact ctcgccagac 1380 ctctcttacc agcagccagc tggctgagga aaagaaggaa gagaagacct ggaaggggag 1440 cataggattg ctgctgggga aggagcacca tgagcatgcc tctgccccac tgctgctacc 1500 cccacccacc tcagcactgt cctccatagc ctccactacg gcagccagca gtgcccacgc 1560 caagacaggc agcaaggaca gcagcacaca gactgacaag agtgccgagc tcttctggcc 1620 cagcatggcc tcccttccca gccgcggccg gctgagcacg acccctgctc acagccccgt 1680 cctgaaacac ccagcggcca aagggaccgc agagaaactg gagaactctc ctggccatgg 1740 gaagtcgcct gaccacagag gccgggtcag cagcttgctg cacaagcccg agttccctga 1800 tggagagatg atggaagtcc tcatctaact gccatccctg tggaatttca gtacagaaca 1860 ctgacaaaca aggaaagcgg cagagaaaga agaaagacct agaaggttgt agatgggaaa 1920 tcaggaatga tttgaactga taaagatttc agactcataa gaacacattt tataaatgtt 1980 aaacacaaaa actacatgac tgaagataga agagaatgcg atggatttta ttacacatgg 2040 tggaagagag aagaggcgtg taggtttgca aacaaagtta agaaatagga aactgaattt 2100 ttcattgtac agaaaatgta tctcttgggg agggcctgtg tacccccatt ctctgattat 2160 aaacagataa acccaaatgt ggatcatcct tggaataccc ccattcgcct tgcctcttag 2220 catgtttgat ttaagagaag cctccaggaa atcttgagng cctgtgttgg c 2271 <210> 9 <211> 1240 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:249170.1:2000FEB01 <400> 9 tccgcctgtg ctggacactc cctttctcct gcagccatgg atgccgctct gctcctgaac 60 gtggaagggg tcaagaaaac cattctgcac gggggcacgg gcgagctccc aaacttcatc 120 accggatccc gagtgatctt tcatttccgc accatgaaat gtgatgagga gcggacagtc 180 attgacgaca gtcggcaggt gggccagccc atgcacatca tcatcggaaa catgttcaag 240 ctcgaggtct gggagatcct gcttacctcc atgcgggtgc acgaggtggc cgagttctgg 300 tgccacacca tccacacggg ggtctacccc atcctgtccc ggagcctgag gcagatggcc 360 cagggcaagg accccacaga gtggcacgtg cacacgtgcg ggctggccaa catgttcgcc 420 taccacacgc tgggctacga ggacctggac gagctgcaga aggagcctca gcctctggtc 480 tttgtgatcg agctgctgca ggttgatgcc ccgagtgatt accagaggga gacctggaac 540 ctgagcaatc atgagaagat gaaggcggtg cccgtcctcc acggagaggg aaatcggctc 600 ttcaagctgg gccgctacga ggaggcctct tccaagtacc aggaggccat catctgccta 660 aggaacctgc agaccaagga gaagccgtgg gaggtgcagt ggctgaagct ggagaagatg 720 atcaatactc tgatcctcaa ctactgccag tgcctgctga agaaggagga gtactatgag 780 gtgctggagc acaccagtga tattctccgg caccacccag gcatcgtgaa ggcctactac 840 gtgcgtgccc gggctcacgc agaggtgtgg aatgaggccg aggccaaggc ggacctccag 900 aaagtgctgg agctggagcc gtccatgcag aaggcggtgc gcagggagct gaggctgctg 960 gagaaccgca tggcggagaa gcaggaggag gagcggctgc gctgccggaa catgctgagc 1020 cagggtgcca cgcagcctcc cgcagagcca cccacagagc cacccgcaca gtcatccaca 1080 gagccacctg cagagccacc cacagcacca tctgcagagc tgtccgcagg gccccctgca 1140 gagccagcca cagagccacc cccgtcccca gggcactcgc tgcagcactg agccccctga 1200 ggcccacagc cacccaggca gggcagcaag tggcctggtc 1240 <210> 10 <211> 1564 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:813218.1:2000FEB01 <220>
<221> unsure <222> 307, 317-318, 335, 918, 921, 943, 1011 <223> a, t, c, g, or other <400> 10 aggcaaggga catggactct tctcatagga tgcacagtca agtcacgtga caggaataca 60 taatgttaat acatttgagg aataatccta acacatcaag ttaaagtaag ctgcttttga 120 tccccctttt gaaaaggatg ccagtttagt tgttacatac caagtgccag aggctgagtt 180 tttttttttc ctggtgaaga tattgcattc gttgaaaaca aaaccacact gagttaccat 240 ttcatgttca ctaggatgac tgcagtcaaa aagatggaaa attgcaagtg ctgttgagga 300 tgtgaancaa ttggaanntt catgcactac tggtnggaaa gtgaaatggt gcagtcactt 360 tgggaaagtt tggcagttct tcaaatggtt aaacgtagag ctactatatg gcctagcaat 420 tccccttaca ggcatatgcc caagataatt gaaaatatat gttcagggct accctctttg 480 ggtcccctcc ctttgtatgg gagctctgtt ttcactctat taagtcttgc ttctgcactc 540 ttctggtcca tgtttgttaa ggctcgagct gagcttttgc tcgccgtcca ccactgctgt 600 ttgccaccgt cgcagacccg ctgctgactc ccatccctct gaatctggca gggtgtccgc 660 tgtgctcctg atccagtgag gcgcccattg ccgctcctga tcaggctaaa ggcttgccat 720 tgttcctgca cagctaggtg cctgggttcg tcctaattga gctgaacact agtcactggg 780 ttccatggtt ctcttctgtg acccacagct tctaatagag ctgtaacact caccgcatgg 840 cccaaggttc cattccttgg aatccataag gccaagaacc ccaggtcaga gaacacgagg 900 cttgccacca tcttggangc nacccaccac catcttggaa gtngctcgcc accatcttgg 960 gagctctgtg agcaaggacc cctggtaaca ctttggtgac cacgaagtga ncctccaagg 1020 tgaattgaaa ctgtaaaact acaaatggtt catcaaatgg agccccagat gcagtccatg 1080 actaagatcc accgtagacc cccggaccgg tctcccagcc catgctctgg tgttaatgac 1140 atcgaaggca cccctcccaa ggaaatctca gctgcacaac ccctcctatg ccccagttca 1200 gcaggaagca gttagagcag tcatcggcca acctccccaa tagcacttgg gttttcctgt 1260 tgagagtggg gactgagagg actagctgga tttcctaggc cgactaagaa tccctaagcc 1320 tagctgggaa ggtaactaca tccatcttta aacatggggc ttgcaactta gctcacaccc 1380 aaccaatcag agagctcact aaaatgctaa ttaggcaaaa acaggaggta aagaaatagc 1440 caatcatcta ttgcctgaga gcacagcggg agggacaagg atcaggatat aaatccaggc 1500 attccagcca gcaatggcaa ccccctttgg gtcgcctcct tgtatgggag ctctataagt 1560 actc 1564 <210> 11 <211> 284 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:902522.3:2000FEB01 <400> 11 gtggtctgag tttgtggctg catttttatc tctggtggct ctgctacggc ggcgcagaaa 60 tgaggcagaa gcggaaaggg tgaaaaccaa gacagctgcc aaatatggcc tttctgccca 120 gccccgcctg gtggatatca ttgctgccgt ccctcctcag tatcgcaagg tcttgatgcc 180 caagttaaag gcgaaaccca tcagaactgc tagtgggatt gctgtcgtgg ctgtgatgtg 240 caaaccccac agatgtccac acatcagttt tacaggaaat atat 284 <210> 12 <211> 1209 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:474304.1:2000FEB01 <400> 12 attttaggta ctttgtttat ggatctgttg aatctgagga gaagtgattg ctttgagtta 60 gctagtttta aattcatgac actttcccaa cataattagg tatttgaacc taagtgtgtg 120 ctagtgtatt gtatattttt cattaattac tttattgaaa gttgctttgg gaatcaattc 180 acttcaatat attttactgt tctcagtgaa gaatgtgact aataagtatt tggactttca 240 aaaagtgata cagtctttgt gatagttttt tacctttaca ttaatgagtt ggaaaataac 300 tttgttcaaa ggaatagaaa tgcatatttt gcttaaatat taacaatatg tttttaattc 360 agtgtgtctc agtaaactat gttttggatt gctgtgtttt tacctcatgt ttattttttc 420 tgtctacctg gtaatttgag aaccctcgct tgcaacatat caccatatta ttcgcctgtt 480 tgatcaacct ggagaccctt taaagagatc atccttcatc atttatgata taatgaatga 540 attaatggga aagagatttt ctccaaagga cccggatgat gataagtttt ttcagtcagc 600 catgagcata tgctcatctc tcagagatct agaacttgcc taccaagtac atggcctttt 660 aaaaaccgga gacaactgga aattcattgg acctgatcaa catcgtaatc tctattattc 720 caagttcttc gatttgattt gtctaatgga acaaattgat gttaccttga agtggtatga 780 ggacctgata ccttcagcct actttcccca ctcccaaaca atgatacatc ttctccaagc 840 attggatgtg gccaatcggc tagaagtgat tcctaaaatt tggaaaggtc agttttactt 900 tttatgtgtc cgggtgcatc tcacctcaat atcctctact ttgataatga atgtgctaac 960 attactgtta gggatgaaaa cttccatttt gactgaacca aatgtgttag ttgagatgta 1020 cttcaaggtc atgtgctcat gttgcatgtt ggctatcagg agaaaatttt gttgaaaatg 1080 acttaagtca gtcccttcgt gacataggaa tgagctgagt tttgtgcacc tgttgcagga 1140 tatgacccaa agaaaataaa tgctaatggc gtggcaaacc ctaaatctga ataaaggtct 1200 ttgacccgg 1209 <210> 13 <211> 1358 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:027320.1:2000FEB01 <220>
<221> unsure <222> 95, 1349 <223> a, t, c, g, or other <400> 13 actccgacgg cggctcggac gccgacttcg gaggtgggtc cggggagccc gactcggacc 60 gcggaggtga gcgggagctg aggctgagga gaggngagct tggggggcgc ctgctgccaa 120 gggcagcgga ggaggaaatg gcaggtccta atcaactctg cattcgccgc tggactacca 180 agcatgtagc tgtgtggctg aaggatgaag gcttttttga atatgtggac attttatgca 240 ataagcaccg acttgatgga atcacattgc taacattgac tgaatatgat ctccggtctc 300 ctcctctgga aatcaaagtc ttaggggaca ttaaaaggtt aatgctctca gtccgaaaat 360 tgcagaaaat acatattgat gttttagaag agatgggcta caacagtgac agtcccatgg 420 gttccatgac ccctttcatc agtgctcttc agagtacaga ctggctctgt aatggggagc 480 tttcccatga ctgtgacgga cccataactg acttgaattc tgatcagtac cagtacatga 540 atggtaaaaa caaacattct gttcgaagat tggacccaga atactggaag actatactga 600 gttgtatata tgtttttata gtatttggat ttacatcttt cattatggtt atagtccatg 660 agcgagtgcc tgacatgcag acctatccac cactcccaga tatattctta gacagcgttc 720 ctagaatccc atgggccttt gccatgacgg aagtatgtgg catgattctg tgctatattt 780 ggctcctggt tcttcttctt cacaagcaca gatatatggc agtgtatggg agaaattaca 840 tcgagccttt gccatttgga gtggctttgg tatgaccctg actggcgttc acacatgtgg 900 agattacatg tttagtggcc acacagtcgt cctaactatg ctgaatttct ttgtcaccga 960 atatacacca agaagctgga atttcttgca cactttatcc tgggttctca acctctttgg 1020 aatcttcttc atcttggctg cccatgaaca ttattctatt gatgtgttta ttgcttttta 1080 tataacaaca agactctttt tgtactacca tactctggcc aataccagag catatcagca 1140 gagtaggaga gcaaggattt ggtttcccat gttctctttt tttgaatgca atgttaatgg 1200 cacagtacct aatgaatatt gttggccatt ttcaaaacca gcaataatga aaagactaat 1260 tggatgaata ctatctttct aatgaatttg tgattaaata tatcatagtt gttgaaaatg 1320 agtaactttg cgttctcccc ctaggttcnt cttaaagc 1358 <210> 14 <211> 1035 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:228319.1:2000FEB01 <400> 14 caaagctggt ttcaagccac tttcctagtc tttgttgaat ggtaaatgtt ccttcaagag 60 ttgcaggaag agcatgcctt gcttgcgcca tggggtgggg ctgcaccatc ttgcttgctg 120 cgtgtgcttg tattgttcat catacacaat tcatggtttc ttttcaggaa tttttgaagt 180 cgcttgtcca ttctatgaag gtcagtttgg ttaaaattaa agcattttaa ctgagtactt 240 acaaactgta gtagacccag ataggctgaa agcaaaagta ggatggaggg cttggcttcg 300 gtgaggacca agcctcttct gtcagccact cctgtgcgac tgtcaggccc agggatccac 360 tcagggaagg tacctgtgtc aacctcaata ttaactgtta tcaaagcttc ctgtctcttt 420 tattttagcc agaagcaata cttttaatgg attccttcca cgtccaaatg gatcatgtgt 480 acccctcctg ggcaaccacc ggaagactct gggtattgtg tgcgttgtcc gctcagtgac 540 gaggatcttc ataatttcct tcctgcaaaa aggacattag ttttcagtgt ttccaacaat 600 tatccagcaa taccatctaa acaccatttc tgtaatctag gagcaagctg aagaggaaaa 660 gaagcccaag gatagcacaa ccccttttga gtcacggtta tcccaatcca gaaaattttc 720 ctggacagaa tacctggaag ctactcaaac caatgcagtt cctgccaaag tttttaaaat 780 gaggttgcct catggttttc tgccaaatat gaaacttgaa gttgtggata aacggaaccc 840 caggttaatt cgtgttgcta cgattgtaga tgttgatgac caaagagtaa aggttcattt 900 tgatggttgg gaccataagt atgactactg ggtggaggca gacagccctg atatccaccc 960 gatcggattg tgtgatgtca cagggcatcc actggaagtg ccaaagcgaa cgaaatgacc 1020 tgaagatcct tccag 1035 <210> 15 <211> 912 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:197267.2:2000MAY19 <220>
<221> unsure <222> 24 <223> a, t, c, g, or other <400> 15 cgtgctgcag ccgccgctgc tgcngctcct gctggcgctg ctgctggcgg cgctgccgtg 60 cggtgccgaa gaggcctcgc cgctgcgccc cgcgcaggtc acgttgtcgc cgccgccggc 120 cgtgacgaac gggagccagc cgggcgcgcc acacaacagc acgcacacgc gtccgccggg 180 ggcgtcgggc tcggcgctga cgcgctcctt ctacgtgatc ctgggcttct gcggcctgac 240 cgcgctctac ttcctgatcc gggcgtttag gttgaagaag cctcagcgga ggcgatacgg 300 cctcctcgcc aacactgagg accccacgga gatggcctcg ctggacagcg acgaggagac 360 ggtctttgag tcccggaatc tgagatgatg ctgagccagg gaggcggccc ttccagcagc 420 catgagggaa ggacaggaga tggggcccac cccagtgccc agcaaccccc tgctccaccg 480 ctcattcccc tgctggcccc ggggctggtc tcacccagtg cccagcaacc ccctgctcca 540 ccgctcattc ccctgctggc cccggggctg gtctcaccca gtgccaaccc gagagctcct 600 tttggaacct gcacagcccg ccgacctgtt gccacctgca cccaccgctg gaccatgcag 660 cctcgcctcc tggatgctgt cccagcctgg ccgagggtcc caggtgaaga ctggagggac 720 cccaacagcc accgcccagg acgctgaggc tcccttgcct gactgtgact tgtgcctctc 780 tcctgccccc gtggggacat ggcagcccag agccaaggct gggtgggcag gtgacccaag 840 gaacctttct gggaacacct tctcgccggg ctgggaacaa taaatgcagc catgtctctg 900 cagctggtgc tg 912 <210> 16 <211> 1615 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:403332.1:2000MAY19 <220>
<221> unsure <222> 99, 1070 <223> a, t, c, g, or other <400> 16 cgggctgttc ctgtaaggcg gggagacaat gagtaaactc tccttccgag cgcgggcgct 60 ggacgccgcc aagccgctgc ctatctaccg cggcaaggnc atgcctgatc tcaacgactg 120 cgtctccatc aaccgggccg tgccccagat gcccaccggg atggagaagg aggaggaatc 180 ggaacatcat ttacagcgag caatttcagc acagcaagtg tttagagaaa aaaaagagag 240 tatggtcatt cctgttcctg aggcagagag caacgtcaac-tattacaatc gcttgtacaa 300 aggagagttt aaacagccaa aacagttcat tcatattcag cgcatttggg gacactacca 360 accggagacc acgttaaagt ttttgcttgt ttgttttgtt catttgtttt tggaccacag 420 tattagcttt aatttaggct gcagatctgc tcaaggttca gttctcagga agattttttg 480 cttctccttt ctacctaagg gcaagttgag aaatacaaaa ttctttgctt tccctttctg 540 catggctaat ttatttcttt aatcttacac tgagggcata gccctttggt aatgtatctt 600 8!104 tattcagtag cattctatac taatattaac acacaagcat aaagcttttt tctttcttat 660 ggtatatata gtaatgttgt gtctttaatt gatggcagtt tagatttgat agaattcaat 720 aatagtcata ttctctagta tgaatattag gttctttgta atttgttccc gctttctcct 780 ttaacgtcat ttatttttgc tcttcccttc actctgtgta ccatagggac tacgaaaatt 840 accctcattc accttctttc atatttaaca tttccttgga tgtgctattg aagtcttctt 900 tcccttccta tagctcatta aagacttaac tcccttatga aagccacctt gacttttctc 960 actctacctg tcttctttgc ttatcgtagt atcttttaca tacttctgtt agaggactca 1020 ccatacttta ttgcaattat ttgtaaccat tctttctctc cttttagacn gtgagctcct 1080 tgagggcagg aactatatat tttattttct tttgtgtttt cagagtaaag tgcttggttt 1140 atagatgctc aataaatgat gtgtttgtcg actgaattgt tttaaaatgg ctttaaaaag 1200 tcttttggtg gtacagccat tttccacaga tttcttttct ctgaaatagt ctagagaaac 1260 acacatgcga aaattattta tgtatatttt tttctcctgt gttctttgac tttgagtcct 1320 attagctttt tgaatttgcc tttaccttct atcagtcagg aaggagataa ctattcataa 1380 tagaaatttt aaggatctct cttaagccaa agtatcaatt attttgtatt ttgataatat 1440 tgcagttagg caggaagacc atttgtaaaa accattctag gaaaccaaga actaaaaatc 1500 gggtgtaact catgtgggtc aggcccatcg aatacaataa acattattct tgtgttggtt 1560 tttttcattt cattttattc tattattgta aaaaacaata aaaataatag aaatt 1615 <210> 17 <211> 880 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:983076.3:2000MAY19 <400> 17 aatggaactt aatgtctatt cctcttttct cttttctgtg ttaccaaagg gatctagagc 60 cttatgggta ctacttagaa aatgagcact catacatata caatatctgg aaataccttg 120 aaagtaatca cgaatactcc ttctgtttca cttccatact gctgaattgc ctcttcatct 180 tctgtcacca taacaattgg catcctgtcc tggcagtgat gatagtacca aacagctgcg 240 ttgtatatgc tcctggtctg ccacttctcc atggactctc ctctttcccg tggcagatag 300 cagcattgct ggaattcatt agcaaagaga atgcaatcat gacgcgcatc cttcagcagg 360 tttcgcagtt tgttatactg tctgtgacac ggaggagaaa aataactcta acaaagcagg 420 tactcatcca ctgctatctc ttgctaagga tcaaaaaagg atggggtatt ttagagccaa 480 agattgatta ctttaaacct gaagaacatg tatttatatt ggtctcagtg tgctcagtcc 540 tatcgggctg ctattgtttc tcgattttgc ctgctagaag gtgcttgggc agggcctagt 600 taattagttt gcagatcaat taaactcctt ccctctcctt tccccttcag agacttccag 660 ccattttatt atgtaattat accaccttgc cctgcctagc cccttcttca aagcctgagt 720 gcacggaggc aagcagagag tttagcactt tatttttgga cctcactttg ttctataaat 780 gtcattaagc attaatacat ttgacttttt gctggcagcc ctagacaaga acatgtaagg 840 taaataagtt tggggattta tctgtgaatt taatttatgc 880 <210> 18 <211> 1049 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:216612.3:2000MAY19 <400> 18 cgggtaccgg gcctcacgga tccgcgccgc gccccccacc tgtgtgctgc gcgcggggtg 60 ggctgcgctc ccctgggcgg cgccgggcgc ccggggctgg tggcgagatg ggccgctact 120 ctggcaagac gtgccggctg ctcttcatgc tggtgctcac cgtcgccttc ttcgtggcgg 180 agctggtctc cggctacctg ggcaactcca tcgcgctgct ctccgactcc ttcaacatgc 240 tctccgacct gatctcgctg tgcgtgggcc tgagcgccgg ctacatcgcc cggcgcccca 300 cccggggctt cagcgccacc tacggctacg cccgcgccga ggtggtgggc gcgctgagca 360 acgcggtctt cctcaccgcg ctctgcttca ccatcttcgt ggaggccgtg ctgcgcctgg 420 cccggcccga gcgcatcgat gaccccgagc tggtgctcat cgtcggcgtc ctggggctgt 480 tggtcaacgt ggtggggctg ctcatcttcc aggactgcgc cgcctggttc gcgtgctgcc 540 tccggggacg cagtcgccgc ctgcagcagc ggcagcagct gtcggagggc tgtgtccccg 600 gcgctttcgg ggggcctcag ggcgcggagg acccgcggcg cgcggcggac ccgacagccc 660 caggctcgga ctcggccgta accctccggg ggacctcggt ggaaaggaag cgggagaagg 720 gggcgaccgt gttcgcaaac gtagcaggtg attccttcaa cacccagaat gagccagaag 780 acatgatgaa aaaagagaaa aagtctgaag ctctgaatat cagaggtgta cttttgcatg 840 tgatgggaga tgccctgggg tccgtggttg tggtcatcat cattttgtca tctgccttcc 900 cgcttatcaa ggagaccgct gccattctgc tacagatggt cccaaaagga gtcaacatgg 960 aagagctgat gagtaaactc tctgctgtgc ctggaattag cagtgtacat gaagtgcaca 1020 tctgggaact tgtaagtgga aagattatt 1049 <210> 19 <211> 958 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:322465.1:2000MAY19 <400> 19 acttccagaa tgtcacactg cttttgcaca ctctcaaata ggcatctgct tgtgtgggag 60 ctgtgattcc ctctcccctc cccactgtcc tctagtattg tttaaaaatg acggaagaaa 120 caatagctag ctccacagaa gtcatcctca caagccagat gtcaagtgag ggctggcaac 180 gttggggcaa aattaaaagt gatggagggg gaaacagtgg tgtgcccctt gggtggatag 240 aaggtttcat taatgtctgt gatggaatca tgaaccacaa cagtgaggca tttccgcctc 300 tggccttttt ttggtttttg ttttttttag aatcaggatc tcaaaaaaaa taaaaataaa 360 gaaaacaaat taaagttcat cagtcatgaa gcctccattc caggccctag ctccaggatg 420 acaattctag acacatcctg ggccagaagg gaatctgctg ccctgaaggg aaggtcccag 480 tcctagcagc atacatcacc tgataactga agagcccttg ggccctgaat aaccagcaga 540 gagccaggcg cggtggatca cacctgtaat cccagcactt tgggaggcca aggcaggtag 600 atcacttgag tccaggagtt caggaccagc ctagccaata tggtgaaact ccctctctac 660 taaaaataca aaaattagcc aggcgtggtg gcacacacct gttaatccca gttacttggg 720 aggctgaggc atgagaatca cttgaacctg ggaggcggag gcggcagtaa gccaagatca 780 cgccccttca ctccagcctg ggcaacaaag tgagactctg tctcaaaaaa ataaatttaa 840 aaattaaaaa ataatcagca gtgacaccca ggtacccaag tactacattg gagagcttgg 900 tgattataaa agaccttatc ttttataatg ccagaagcaa gtcaatctta tttcaaac 958 <210> 20 <211> 830 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:093477.1:2000MAY19 <400> 20 ggagcctggt ttgttagatg ttactttaga aataataaca gcactttatt gctgttatta 60 ttgagtgctt actatatact aggtgcatta ttcatcataa tcattaacaa tgaatttttt 120 ttttgagatg gagtctctct ctgttgcccg ggctgagtgc agtgccgtga tcttgactca 180 ctgcaacctc cacctcttgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctag 240 gactacaggt gcacaccacc acgcctggct aagttttgta tttttagtag agatgggggg 300 atttcaccat gttggccaga ctggtcttga actcctgacc tcaagtgatc cacctgcctc 360 ggcttcccaa agtgctggga ttataggagt gagccacccc acccagccaa caacgaatat 420 taatgcagta cttatgatgt accaaactca taagcacact tacctcacca ggtcttagaa 480 gaacactccc tctggagcca tcacgtacgc gtgaggacat tgaggccctg agcttagata 540 acttgttcaa aatggccctg ctgataagct acatggacga agtcagcggt tttgggcatg 600 tctttccacc agcttctgga agaacagcac acaggccgtt cccctctccc ccattttaaa 660 gtggcaggag aaggtggaat gaagaaaata aacagggctg ttcctggctc tgtgtggtca 720 gagggtgata ctggttcagg gtccagctta tcagtgctgc actgatattc acagagcatt 780 cggctccgga ggctttgcac tgtttgtaat gcattgtcaa aacttggtgt 830 <210> 21 <211> 2591 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:222880.1:2000MAY19 10!104 <400> 21 cgtcgcccaa ggtcgcgggc cgcttgggga gtcagcagcg cgccaggccc cttcgggccc 60 cacacgcatt aggtgccttc tagaagggta cggagtgaac gcgggcggcg gcgggaccga 120 ggcagcgccc agtttgtaac cgccgcgccg cccgtgcccg cgcgcgccac accccagcgc 180 gcttccggcc gggccacgtg accgcgcgtg cacgtgttcc ggcctctccg cttcgccgct 240 ccgaacctcc tcctggtcgt cccggcattc gtccacgcgg agccggcttg ggcggggccc 300 gggaggcggc ggccggagaa gccgcggaga cgcgagcgcc gagcgtcgcg agggagcagg 360 cccgggcagg caagcggcgg cctccgccat gaaccccagg ggcctgttcc aggacttcaa 420 ccccagtaag tttctcatct acacctgcct gctgctcttc tcggtgctgc tgcccctccg 480 cctggacggc atcatccaat ggagctactg ggccgtcttt gcccccatat ggctgtggaa 540 gcttctagtc gtcgcaggcg cctccgtggg cgcgggcgtt tgggcccgca accctcgcta 600 ccgcaccgag ggagaggcct gtgtggagtt caaagccttg ctgatcgctg tgggcatcca 660 cctgctgctg ctcatgttcg aagtcctggt ctgcgacagg gtggagaggg gcacccactt 720 ctggctgctg gtcttcatgc ctctcttctt cgtgtccccc gtgtccgtgg ctgcctgcgt 780 ctggggcttt cgacacgata ggtcgctgga gctggagatc ctgtgctcgg tcaacatcct 840 gcagttcatc ttcatcgccc taaagctgga caggattatt c'actggccgt ggctggtggt 900 gtttgtgccc ctgtggatcc tcatgtcgtt cctttgcctg gtcgtcctct attacatcgt 960 ctggtccctc ctgttcctgc ggtccctgga tgtggttgcc gagcagcgga gaacacacgt 1020 gaccatggct atcagttgga taacgattgt cgtgcctctg ctcacttttg aggtcctgct~1080 ggttcacaga ttggatggcc acaatacatt ctcctacgtc tccatatttg tccccctttg 1140 gctttcctta ctaactttaa tggccacaac atttaggcga aaggggggca atcattggtg 1200 gtttggcatt cgcagagact tctgtcagtt tctgcttgaa attttcccat ttttaagaga 1260 atatgggaac atttcatatg atctccatca cgaagatagt gaagatgctg aagaaacatc 1320 agttccagaa gctccgaaaa ttgctccaat atttggaaag aaggccagag tagttataac 1380 ccagagccct gggaaatacg ttcccccccc tcccaagtta aatattgata tgccagatta 1440 aactcctaga gaggacccag gcacacacag actccacttg gccttcgcct cttgttcatt 1500 catcccaaac ctggaaatgg aaacaggctt caaacactcg tctcacgccg tgtttgagat 1560 caccgcctca tcagtatgca tcatagatgg aggtggtttc agtatgtggg tgtgtgtgat 1620 gtgtacctgg gtaagagact tgctttccag gttcgcactt tcaggtgtag ctgggggcag 1680 taagtcgaat tgttttagta ggtcctcaaa aggaataacc acacagctgt ttgtttaaat 1740 gctactgtac ctatcaaaac tattgtttaa aaagtatttt tatacactgc taatctaaaa 1800 ttgtatttca gattgtgcct gtcataacaa tagcaaatgt aaaaagttct ctttcccacc 1860 acttgtttat aaacctcata gttgatattt ttagtgttcc tactgttaaa atactctctc 1920 cttgggcttt gctgatactg gtctttaata ttctgatagg tgaatttttc taatggaatg 1980 aacccatgca tatatagtat ttatatgaat attttagcag tgtaatatgt tgaattctag 2040 ttctctgcat taccattatt acgttaaagt attttttaaa gcttaggtgt gaagatatgt 2100 gtctattgca gatgtccttg aaaactgcat aaaacagtat gtgcctggtg tggatcttac 2160 caaagtacta ggcatgaatg tagggactgc aaatcccatg ggtcttaata tttaggtgtt 2220 agtaaccaag gtctctggta gtacccgtta gtagaggaag aggccactgc ccttgggaac 2280 ttgtgacagg ctctagtgtg gtaccaggcc ataaagtgac actgttattt agcaacttga 2340 atttttccac acaggtagta actgtgtgga aataagcaac aagtggtttg tccatttcta 2400 agaatcttaa actattagtt ggctgtagtg tgaagcatta cttgtcattg gaaagatgga 2460 gagagtggcc ttaaccggaa gtggtcagta gaagcaggtg tcattttaag ggccaaactt 2520 taatctgtca gcaataggga aacaactgtt caaattatct ttgtagataa gaacagtgtt 2580 tcttttttct t 2591 <210> 22 <211> 2482 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:898320.3:2000MAY19 <220>
<221> unsure <222> 2464 <223> a, t, c, g, or other <400> 22 ccctctcttt cgctgtttga gagtctctcg gctcaaggac cgggaggtaa gaggtttggg 60 actgccccgg caactccagg gtgtctggtc cacgacctat cctaggcgcc atgggtgtga 120 taggtataca gctggttgtt accatggtga tggccagtgt catgcagaag attatacctc 180 actattctct tgctcgatgg ctactctgta atggcagttt gaggtggtat caacatccta 240 cagaagaaga attaagaatt cttgcaggga aacaacaaaa agggaaaacc aaaaaagata 300 ggaaatataa tggtcacatt gaaagtaagc cattaaccat tccaaaggat attgaccttc 360 atctagaaac aaagtcagtt acagaagtgg atactttagc attgcattac tttccagaat 420 accagtggct ggtggatttc acagtggctg ctacagttgt gtatctagta actgaagtct 480 actacaattt tatgaagcct acacaggaaa tgaatatcag cttagtctgg tgcctacttg 540 ttttgtcttt tgcaatcaaa gttctatttt cattaactac acactatttt aaagtagaag 600 atggtggtga aagatctgtt tgtgtcacct ttggattttt tttctttgtc aaagcaatgg 660 cagtgttgat tgtaacagaa aattatctgg aatttggact tgaaacaggg tttacaaatt 720 tttcagacag tgcgatgcag tttcttgaaa agcaaggttt agaatctcag agtcctgttt 780 caaaacttac tttcaaattt ttcctggcta ttttctgttc attcattggg gcttttttga 840 catttcctgg attacgactg gctcaaatgc atctggatgc cctgaatttg gcaacagaaa 900 aaattacaca aactttactt catatcaact tcttggcacc tttatttatg gttttgctct 960 gggtaaaacc aatcaccaaa gactacatta tgaacccacc actgggcaaa gaaagtatcc 1020 ctttaatgac agaagccaca ttcgatactc tgcgactctg gttaataatc ctgctgtgtg 1080 ctttgcggtt ggccatgatg cgtagtcacc tgcaagctta tttaaattta gcccaaaaat 1140 gtgtggatca gatgaagaaa gaagcggggc gaataagcac ggttgagcta cagaaaatgg 1200 taatcattcc tggggtattt atccagaatc tatctctacc ttaccagtgg ataatagtct 1260 actgtccaat tctgtttact ctgaattacc atcagctgaa gggaaaatga aggtaactgt 1320 tacacaaata acagtggcac tgagcagctt aaaaaatatt tttactcctc ttctttttcg 1380 aggacttctg tcttttctga cctggtggat tgctgcttgc ctcttttcta caagcctttt 1440 tgggcttttc tatcaccagt atctgactgt ggcatgaatc tcagttaaca aaaaagcata 1500 tccaaatcac cctttaaatt aaaatatctg tgcccttaaa gggctgatga aaaccagaag 1560 aaagcaaata caatgggaaa aaaaaaacat atcagaatgt cttgtattaa atgtttcctc 1620 tgtattctca gggtgaatta atgtagtaat atttaaaatt acaaaataga ttgttaactg 1680 ttacactgtg gcattggaat tttaactctt tgtatttact ggtatgagag ggctatctac 1740 aagggtaata tttctgatta ccctggttta cagaaacctc cagcagtctt tgaaacatct 1800 cacatgactc tagttattga ttgcttttaa tggttttatg gtactgttga tagtcatagt 1860 ggctgcctat agaacaatct tcaaactgag ccatgcttta ggggagggaa aggggctaaa 1920 gtctcttctg ttggtaattt attagttact cttgaaacaa taaaatccaa cagaaaggaa 1980 gagatagcta ctgtatatta cagtaaagaa agctgcatag ttattttaaa tttaatggag 2040 atgaatatgg ttaaaatata taactactgc tgcttgagaa tagcaagagt attgttttaa 2100 aacatattcc acccaacttg agagttcttt taaaatgatt ggccatatga acatttgtaa 2160 tcttgccatt aggtttggac ctgccatatt ttgttttatt ctgtgatcct aactagttcc 2220 ttttaatagg ctaaaatatt tatcaatact gatcagactt taaagaaatt actttgtaaa 2280 cctgctgact acctgtatgt attgtatata tattatatat taaatatata atatattgag 2340 attataaaag atgaaaatat tgaatcctta taatatttta agttgcagaa tgtatgttaa 2400 aaagtgactt gaatgagatg tatttgtatc tagaaatttt atttcttttt ggaatgagat 2460 taanatacat tttgaaagtt ca 2482 <210> 23 <211> 1334 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1327047.1:2000MAY19 <220>
<221> unsure <222> 307, 317-318, 335 <223> a, t, c, g, or other <400> 23 aggcaaggga catggactct tctcatagga tgcacagtca agtcacgtga caggaataca 60 taatgttaat acatttgagg aataatccta acacatcaag ttaaagtaag ctgcttttga 120 tccccctttt gaaaaggatg ccagtttagt tgttacatac caagtgccag aggctgagtt 180 tttttttttc ctggtgaaga tattgcattc gttgaaaaca aaaccacact gagttaccat 240 ttcatgttca ctaggatgac tgcagtcaaa aagatggaaa attgcaagtg ctgttgagga 300 tgtgaancaa ttggaanntt catgcactac tggtnggaaa gtgaaatggt gcagtcactt 360 tgggaaagtt tggcagttct tcaaatggtt aaacgtagag ctactatatg gcctagcaat 420 tccccttaca ggcatatgcc caagataatt gaaaatatat gttcagggct accctctttg 480 ggtcccctcc ctttgtatgg gagctctgtt ttcactctat taagtcttgc ttctgcactc 540 ttctggtcca tgtttgttaa ggctcgagct gagcttttgc tcgccgtcca ccactgctgt 600 ttgccaccgt cacagacccg ctgctgactc ccatccctct gaatctggca gggtgtccgc 660 tgtgctcctg atccagtgag gcgcccattg ccgctcctga tcaggctaaa ggcttgccat 720 tgttcctgca cggctaagtg cctgggttcg tcctaattga gctgaacact agtcactggg 780 ttccacggtt ctcttccgtg acccatgact tctaatagag ctgtaacact caccgcatgg 840 cccaagattc cattccttgg aatccgtgag gccaagaacc ccaggtcaga gaacacgagg 900 cttgccaccg tcttggaagc agcctgccac tatcgggagc tctgggagta aggaccccca 960 gtaacatttg gtgaccacga agggatctcc aaagcaatgg gaaacgttcc ccccaaggca 1020 gaaacgcccc tgagatgtat tctggagaat tgggaccaac tggactctca catgctaaga 1080 aataaacgac ttatattctt ctgcagtacc acctggccac gatatcctct tcaaggggga 1140 gaaacctggc ctcctgaggg aagtataaat tataacacta gcttacagct acacctcttt 1200 tgtagaaaag aaggcataag gagtgaagtg ccatatgtac aaactttctt ttcattaaga 1260 gacaactcgc aattatgtaa aaagtgtgat ttatgtccta caggaagccc tagagtctac 1320 ctccctaccc tggt 1334 <210> 24 <211> 937 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:235157.21:2000MAY19 <400> 24 ttccacgccc gagggcatcg cgctggccta cggcagcctc ctgctcatgg cgctgctgcc 60 catcttcttc ggcgccctgc gctccgtacg ctgcgcccgc ggcaagaatg cttcagacat 120 gcctgaaaca atcaccagcc gggatgccgc ccgcttcccc atcatcgcca gctgcacact 180 cttggggctc tacctctttt tcaaaatatt ctcccaggag tacatcaacc tcctgctgtc 240 catgtatttc ttcgtgctgg gaatcctggc cctgtcccac accatcagcc ccttcatgaa 300 taagtttttt ccagccagct ttccaaatcg acagtaccag ctgctcttca cacagggttc 360 tggggaaaac aaggaagaga tcatcaatta tgaatttgac accaaggacc tggtgtgcct 420 gggcctgagc agcatcgttg gcgtctggta cctgctgagg aagcactgga ttgccaacaa 480 cctttttggc ctggccttct cccttaatgg agtagagctc ctgcacctca acaatgtcag 540 cactggctgc atcctgctgg gcggactctt catctacgat gtcttctggg tatttggcac 600 caatgtgatg gtgacagtgg ccaagtcctt cgaggcacca ataaaattgg tgtttcccca 660 ggatctgctg gagaaaggcc tcgaagcaaa caactttgcc atgctgggac ttggagatgt 720 cgtcattcca gggatcttca ttgccttgct gctgcgcttt gacatcagct tgaagaagaa 780 tacccacacc tacttctaca ccagctttgc agcctacatc ttcggcctgg gccttaccat 840 cttcatcatg cacatcttca agcatgctca gctacgagtc ctcggcggaa atcctgcctc 900 ataccccgag gctcacccac ttccacacaa catacga 937 <210> 25 <211> 2811 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: L,G:085713.1:2000MAY19 <220>
<221> unsure <222> 2789, 2799, 2805, 2807 <223> a, t, c, g, or other <400> 25 ctttgaccaa gtcatttgac ctctctgggc ccatctttat tggaaaatgt caagtagatg 60 gtctctaata aatttttgtc cagttctaac attatgtgat tctaaatgta tttatactga 120 ccttcttaac ttgaactctt tgttttttca gcatttagta tgagaaccta tgtttgccat 180 atttgtagta ttgcttttac atctttagat atgttccggt cccacatgca aggaagtgaa 240 catcaaatta aagaatccat tgttatcaat ctagtgaaga attcaaggaa gacacaagac 300 tcttaccaaa atgagtgtgc agattacatc aatgtgcaga aagccagagg actagaggcc 360 aagacttgtt tcagaaagat ggaagagagt tctttggaaa cccgtagata cagagaagtg 420 gtcgattcca gacccagaca tagaatgttt gaacaaagac tcccatttga gactttccgg 480 acatacgcag caccatacaa tatttcacaa gcaatggaaa agcagttacc tcattcaaag 540 aagacatatg actctttcca agatgaactt gaagattaca tcaaagtaca gaaagccaga 600 ggactagatc caaagacttg tttcagaaag atgagagaga actctgtgga tactcatggg 660 tacagagaaa tggttgattc tggacccaga tcaagaatgt gtgagcaaag attttcacat 720 gaggcttccc agacctacca acgaccatac catatttcac cagtggaaag ccagttacct 780 cagtggctac caacccattc aaagaggaca tatgattctt tccaagatga acttgaagat 840 tacataaaag tgcagaaagc cagaggacta gagccaaaaa cttgtttcag aaagatagga 900 gatagctctg tagaaacaca caggaacaga gaaatggttg atgtcagacc cagacataga 960 atgttggagc aaaagctccc atgtgagact ttccagacct attcaggacc atatagtatt 1020 tcacaagtag tggaaaacca gttacctcat tgcttaccag ctcatgatag caaacagaga 1080 ctagattcta ttagctactg tcaactcacc agagactgtt tcccagaaaa accagtaccc 1140 ttgagcctta atcagcaaga aaataactct ggctcataca gtgtagaatc tgaagtttac 1200 aagcacctct cttcagaaaa caatactgct gaccatcaag caggtcataa acggaaacat 1260 cagaagagaa aacgacacct agaagaaggc aaagaaaggc cagagaaaga gcagtccaag 1320 cataaaagga aaaagagtta tgaagataca gatttagaca aagacaagag catcagacaa 1380 aggaaaagag aggaggatag agtcaaggtc agttcaggaa agcttaagca tcgaaaaaag 1440 aaaaaaagcc atgatgtacc ctccgagaaa gaagaacgta agcacaggaa agagaaaaag 1500 aaatctgttg aagaaaggac agaagaggaa atgctttggg atgagtctat tcttggattt 1560 tgaatgttta gttttgttta cccaaggttg aattgaaaaa aaaaaacagt caatatggat 1620 ttagaaaaag gaacacctga tgaagaaaag gagaggtaga tacagtcagt gtcacttcag 1680 gacacttagg ttttttttgt ataaaaattt aaattgaatt aaaagaagga aaaaaaaagc 1740 ccaaacttaa cctctgagaa aagaacataa gaactcaagg agaacataag agaaaaggaa 1800 acctgttaca gaaaagacaa gaatctgtgt tttggaatga gtctattctt gggtattgaa 1860 cttttagttt tgtttgccca aggattaatt gaggaaatca gctaagaaaa tggactttag 1920 acaaaagcaa gaggatcaga tgaagaaaag gagaggtaga tacagtcagt gtcacttcag 1980 gaaagctatt taaaaaaact tgaaatttaa ttgaaagaag aaacaacaac aaaaaagcct 2040 aaacctagcc tctgaacaac actaacatga gaacacaaga acttaagaga aaaagaaacc 2100 tactcaagaa aagacagaag agacagtgat ttgggatgag tctactctag gattttcaac 2160 tttttagttt tgttccttca aagttgaagg aaaaaaagtt tggttttata aaattcatgt 2220 tattgtaatt tttctaggtg gatggctact ttaatctcta aaaaagccaa gtgaagtaaa 2280 agtattcagt atgccttttc ctcaagttac tttccttcat tttcttaaaa aagaaaaaaa 2340 attattaaat gtttctcaca tatctcacat ataatgtaat ttccctaaat gaagttgtct.2400 ctacttctgc tcatcaaatt gctgtgatag tgaattattt attcatggga gataatttat 2460 tttaaaggac agaattacca agcgttacaa aatcagttct ttccttggtt ttgtgttagt 2520 gttggtggta ttttattgtt gtttttctgt gtttatgtgt ctcagctttc tccaaggaat 2580 atgtatgaaa taacttaaac tgattttttc tttgttaaat ctaatttgca gtgtattttt 2640 gcattttcta gttctgaaag tggaaaatga aacagtctat aataaactta gatgatatat 2700 agttttaaaa cggtctcaaa aagtactgat ataaggtcag tctatattct ggaaatgttt 2760 atattaaagt gttttaattt ctaaaaaana aaaaaaaana gaaananaaa a 2811 <210> 26 <211> 2963 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:482421.1:2000MAY19 <220>
<221> unsure <222> 1741, 1900, 1932, 1972, 2006 <223> a, t, c, g, or other <400> 26 gaggtgcctt gaaattgtaa atgtattttt tttcttttat tttaagctgg taaatacagg 60 gtaaaatctc tttagatctc aatcatgcct attagacaca caattttatt taaactattt 120 aacctgtcag atttaagaaa ataatttgga aaactcactt ttgtaacaaa ttgcaggtac 180 aaaaattact catttggaat agtcagaata cagatgctac tcacctgtga gcacagatat 240 attcatattt ctatgtcaga ccaaaatcct gcttaaacac acaaacattc ctaacaatgt 300 cataatgttt actctttctc ctggcttaat aaactatatt tctgatatta ttggaagatt 360 attgttagaa ttgaaggaga taatacaggt tgagcagccc ttatggaaaa tgcttgggac 420 caaccaatag tgtttcagat tttgattttt ttcaggttat ggaatatttg catacacata 480 aggagatacc ttggtgttgg gacccaactc taaacacaaa attcatttat gtttcctata 540 cacctttaca cagagcctaa aggtaattta tacaatattt taaataagtt tgtgcatgaa 600 aaaagtttgt gtacattgaa ccatcagaaa gcaaaggtgt cactatctca gcgacccaag 660 tggtggtgtc agcactcaaa aagttttgga ttttggggta tttcagattt tagatttttg 720 tatgaggaat gttcaacctg tatttgaaca agcattacca aatatcattg aatattaata 780 tcttttgcgt aaaaactgct attatcagca tcatagtttc tctaaaaaga aaacttgggg 840 atcatagccg atagagagac ttgctaaaat ataaatcagc ctctgcaaaa ctgtttacat 900 atttattggt ttacatattt tattggttta tttctatccc ctgttcactt tttctcttcc 960 acttccaatt atgaagagaa aatatttgtt cagggttgtc cccccgcccc ccgtcactgc 1020 ataatttctc ctcttacaag ctgcttttgg ctttcattaa taacagcttc cttttagaag 1080 gtctgataag gatatttaag gaagaagaga atgactctgt tattaaaggt ggcatggaga 1140 ctgtggaggg aatatttttt aaagcactac tcatatcctt taaactaaat tttgccaaag 1200 cccgagacaa cattaaggag aaattgtacc ttaagttagt aattccaaat ctatctgagt 1260 tgtataccca tcaaagacaa tacagttatt aacatagatg aaggtatgct ataggcatca 1320 ttcattatct ctatattgaa taggtgaaag ataactgtag tcaggtgaaa ggcattcatt 1380 atttttaagc tgaaaagggg atccttgaaa acactgaaaa cctctacaac aatcttcagg 1440 aagcctgcta tcttgggatt cactaataat aggccaagaa caaaggcaag catccattcc 1500 tcactccacc acttttctat ttcagtgggt gtcgttgcta cgatgaagac tttggaaatt 1560 tcctttctct tttaggacag ggtcaggatt taggactcat agcctgaaag ctcattacat 1620 actccttgta accatcagtc caaggttcag ttcactaaag tgcatgttct aaaacaagag 1680 ctatcctcat tccaaatttt aaaatatgta ctctggtcgg ttgcagtggc tcacgcctgt 1740 natcccagca ctttggcagg ccgagatggg cggatctttt gaggtcagga gtttgagacc 1800 agcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta gccaggcatg 1860 gtggcatttg cctgtaatcc cagctactcg ggaggctgan gcaggagaat cacttgaacc 1920 tgggaggcag angttgcagt gagctgagat tacaccactg cactccagcc tnggtgacag 1980 agtgagatcc atctcaaaaa ctgaanataa aaataaaaat atgtattctc ctaactgaaa 2040 tatttactta atctggaaaa caatgtaact atttttaaag tggttacatc tattcttgct 2100 gaagaacaat aaacagaatt ttttgacgaa gcataaccaa atttcagaac agtctaatca 2160 atgccaagta tccaaggcaa actctaatac ccatccattg tgcaaaacca caagcacgca 2220 agtattaaat aagagcaagc tgtcctgagc ccatacctaa tgaatttgtg tcttaaatat 2280 tgtacattgt gtttgaggct tgtcaaaact gggattatgg caagaaaggt tgcctaactc 2340 atacctttct gcctcaaatt ccaggtgcta aaggctaatg gcattttaaa catcttacat 2400 ttttaaaaat ttatattgcc tctg'ccaaac aggcctaata gttaaaagca agttgagaca 2460 aaccaggcag attcagtgtg tggaacagga aggatgtgct ttaaaaaaag gtggaatccc 2520 tcaaaaaatt ctatagggag acagcagcct taatctacat aattcttcat ctcgccaatt 2580 cagccgcagc ctttaaagag ttagtgttaa tggctttctg gtttgaaaac aaaaatgcat 2640 ctatgtggtt gaaagtttgg gaggagattc accaatatct gaggagaaga tggagtgaag 2700 ggaattctta ctttttgctt tatacctttc tataatattt agattttttt ttactgtaag 2760 tatggatcaa attgcaaaat aaagaaaaat gccaacctta gaaaagacaa taaatgcaca 2820 aaagatataa acaggaacag caaatattta tattttttcc attttgctct ttttaaatct 2880 atgtttagaa ctttatatct tgggacttat gtatatatat accttttaaa taaaataaat 2940 tttctaaata aaaagttgaa aaa 2963 <210> 27 <211> 643 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:330944.4:2000MAY19 <400> 27 tagcaggaat tgaacaacat taccaagctc aatgaacact tcagcaaatt tggaactatt 60 gttaatatcc aggttgcttt taagggtgac ccagaagcag ccctaatcca atatcttacc 120 aatgaggagg ccaggaaagc catttctagc acagaagcag ttctaaacaa ccgattcatt 180 cgagtcttgt ggcataggga aaataatgag caaccgacac tacagtcctc agcacagctg 240 ctcctgcaac aacagcaaac acttagtcac ctctcacagc agcaccatca cctgccacag 300 catctacatc agcagcaggt gctagtggcc cagtctgctc cttcaacagt gcacggaggt 360 atccagaaga tgatgagcaa accacagaca tcaggtgcat atgttcttaa caaagttcct 420 gttaaacatc gtcttggaca tgcaggtggt aaccagagtg atgcatcaca tttgttgaat 480 cagtctggtg gtgctggaga agattgccag atattttcaa ctccaggcca tccaaaaatg 540 atttacagct cctcaaactt aaagacacct tcaaagctct gttcagggtc taaatctcat 600 gatgttcaag aagtgcttaa aaaaaaaaaa caaagcggcc gcc 643 <210> 28 <211> 1966 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:223060.1:2000MAY01 <220>
<221> unsure <222> 39 <223> a, t, c, g, or other <400> 28 gggacaaatg actttttctt gttgaggcaa atagcgaana ctctgcttaa tttccacgga 60 atttgtgcca gttttcaaag actacaattt gaagaggcat tatatgcaaa aacgtgctga 120 caaatttggt gtgtatgtgt tgtaaggaca aaatagcaga actgaaaaaa agtctgtctt 180 ttcaacaaaa aagatttttt agaaaagtta caactcggac tcaatcgtaa ggtaaaacct 240 agttatgtgg tagcaaattt aatagcaaaa aaatcaaaac catttactga tggtgagttt 300 attaagcaat gtctggaaga tgtggtagat attatttgcc ttgagaaact gatatttcta 360 aaatcagttt gtctcaccag actatagcca ggagaattgg agaaattggg aaatctattg 420 aaagacgttt ggagagtaaa actgctaatt taaaatttta tgctttggtg atggatgaag 480 gcactgacac tacagatacg gcacaacttg ctatttttat tagaggtatt gatgatgaat 540 ataatgtcac tgaccgaaat cgaaatgtca ccatgctatt aaaagacaca actaaatcaa 600 gagatttata tgaagcagtg aaaaatatgt taaagcaatt ttctttgtcc tttgtaaaca 660 tatgtgatat agctacagat gctgccctgg cgatggtagg taaaaagaga gggacttgta 720 caattaatag atgatgcagt tgccacacaa aactcacatt tgatgaagta ttattgcata 780 atacatcaag aaaatccatg tgcacaagct ttaaaagtag ataacgtcat gcaaattgtc 840 atcaaggctg taaatttcac aagggcccag gaattgaatc atcgctagtt tcaggaattc 900 cttaaaagta tggatgctga ctctagcaag tcattcactt tttagaagta agatggttaa 960 gtcaaggcaa aatgtaaaga ttttatgctt tgtgatgtga aatcaagctg tttatggtat 1020 caaacaaaat tggtgccaga acttgacaat gaaaactggg cttacagatt tagcattttt 1080 agtgggtttg acggcccatt taagtgagtt aaacctgtgt cttcaagttg aaaacccact 1140 ttaccaatac aatgtttcaa accataacag cattccatat gaaactgaaa ttatgggaag 1200 gctcaaatta aggcaaacaa ttttatgcat ttcgacatgt tggctaaaca tggtcctgtg 1260 aacagccaaa aatacgcagc cttgcttttc aatttgatac aggaatttga aaacaggtat 1320 ttcaagattt ctgaaaaaat catcaatatt ttggtatatt tgcaactcca ttttcagtcg 1380 acatatatat gttacctggc aattttgaaa tggaatgcct agagctgcaa tctgatgttc 1440 aacttataga aaaatttgat tttgcctctt tactggactt ttgtaagacc tgtcttccca 1500 atgacaaata tcccttgctt cacaatcaca ccttgttcat gtcattgctt ttggggagca 1560 cttacatttg tgagctacta ttttcaagga tgaagaacac gaagagtaaa attagaacca 1620 aaatatctga tgagcacctt gagaactcac tgagaattgc aactacttcc atcaagccag 1680 atactgatgg attacgtttc tcaaaaacaa tgtcaagtac cccactagtt ttatgttgtt 1740 ctcttttctt ttataataaa aaatatcaaa aaagtagtga agtttagcta gatatgtaca 1800 ttttctgtat cagtgattgc aaacttggaa cctgttcaat gattttgaaa gaccctctga 1860 atggggcagt gcataattag gattattatg caagggacat ttttgcttat ctgtggtggt 1920 agatatataa tgaaaactat acacagacca tttgtgtgtg tgtgtg 1966 <210> 29 <211> 897 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:213087.1:2000MAY01 <220>
<221> unsure <222> 592, 601 <223> a, t, c, g, or other <400> 29 gtcgaggcgc agcgctgcca tggctggggg ccgtggggcc cccgggcgcg gccgggacga 60 gcctccggag agctacccgc aacgacagga ccacgagcta caggccctgg aggccatcta 120 cggcgcggac ttccaagacc tgcggccgga cgcttgcgga ccggtcaaag agccccctga 180 aatcaattta gttttgtacc ctcaaggcct aactggtgaa gaagtatatg taaaagtgga 240 tttgagggtt aaatgcccac ctacctatcc agatgtagtt cctgaaatag agttaaaaaa 300 tgccaaaggt ctatcaaatg aaagtgtcaa tttgttaaaa tctcgcctag aagaactggc 360 caagaaacac tgtggggagg tgatgatctt tgaactggct taccacgtgc agtcatttct 420 cagcgagcat aacaagcccc ctcccaagtc ttttcatgaa gaaatgctgg aaaggcgggc 480 tcaggaggag cagcagaggc tgttggaggc caagcggaaa gaagagcagg agcaacgtga 540 aatcctgcat gagattcaga gaaggaaaga agagataaaa gaagagaaaa anaggaaaga 600 natggctaag caggaacgtt tggaaattgc tagtttgtca aaccaagatc atacctctaa 660 gaaggaccca ggaggacaca gaacggctgc cattctacat ggaggctctc ctgactttgt 720 aggaaatggt aaacatcggg caaactcctc aggaaggtct aggcgagaac gtcagtattc 780 tgtatgtaat agtgaagatt ctcctggctc ttgtgaaatt ctgtatttca atatggggag 840 tcctgatcag ctcatggcgc ccaaagggaa atgtattggc agtgatgaac aacttgg 897 <210> 30 <211> 2792 <212 > DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:405330.1:2000MAY01 <400> 30 ctgtccttaa gatggtcacc atattcttat tcaggctgtt gtcattttcc ccagagatgg 60 tttgtttaac gaatgatagg ctctgtgcct ggggatgtta gcagactctg gggtttgtac 120 agtgatgcct tctccctggc ccagagctga atattcatct agaattaaag ttggatttga 180 tataacaaat ttctttctat acaggtttta cataagagag acagtaataa tgtcaaggat 240 agcctgtgtg ggcagaaatt ggtaatccgg cttttggatt gtcagctgta gagccaactc 300 tgattatcta gccattgatc atacaaattg atagaaacat tagtcagtaa ttttagcttc 360 ttgccaaatt gttcacaaca tctaaatgta atgtgatgtg atgaagataa gtagtacaaa 420 gagaccaaaa taatttggga gaattaggaa tgatgacaat tttttttaac aactttacct 480 ctaatagggt tacttggatg agccaactcc gcttccttcc catggatatg gaaagggact 540 ctgtgtatta ttcaggttta ttggcacgaa gatacttgtt ttaagttcct tgagaaccca 600 tgatggacag ttgacagaat gcttaaacct gtcaaaagat gagtgatttt gtgtgggaaa 660 agccttccca ggcgtctgta ccgaaaggat gcagcaaaca aggggctaat ccatgagcag 720 tgttctgtag gctctgtgac atctttggtt tataggattt tggagccttt tattgtccgg 780 gaactatttg aggggtttca ttataggcct tggttctctc caggggccag atgagtttat 840 tgtggaatct ttgaaaggac aaggcctctg tgaatgaatc agtcccaggg aagcatttgg 900 tggtggcggc agtggaggat tgcccggtga acctataaat cagcagtctc ttgggcagag 960 gagcaagccc ctcgaacatg atttcaaaca agcaggtcct cttctctcat ctcacgtcct 1020 tagtctctgt taatgaacat actggatgtg gagtttaata aattacctac tatcatctgg 1080 ccacttagat tattatcaca ccactgtgga ctgttcctgg ggggagaaga acagaccgat 1140 ttgaaagatt caagggagaa agattaagga tcaggattgc atgaaagaag aaaatccttc 1200 aatatttaaa atgtttctta caatacccac ggagcacttt tatggttcca gccgagcgtt 1260 cctgaaatga actgaccatt aacagcgcct ctttgatagg ttaccctgat gctgctaaag 1320 taaagcctta agtgtgtttt tgggacaacg tgctgcttat tccacctcag ccacatatgt 1380 gtttgtgttt aggatattgt aaatctttgc taagtagtgt tttccttggt gaatgaagtc 1440 attgttgtct tcaagtgtac catctgccta gcaaaaaatt gctacaaact ttctcttatg 1500 gcaatagtcc ttgggtactt ctaatatttt taggcaagag acaattttct gtactaggaa 1560 tcttccactg ccaggaaaac acagtgccag taagggttct acatacacac tgaccatctg 1620 cttaatagac atgtatttcc tttgagtagg acattagctt ttgattataa agctcaacta 1680 gtataagcaa aaatataaca tctagaagca cagttttagc caggatgttt aaaaattaca 1740 gttttgtgag acttaagggt ctttttaacc taggtaagtt tatatgacct aacttaattg 1800 tagccctatt cttggtacct tcccttttgg aaagtagagg ttgcggtaaa caagcgctag 1860 ggtattataa gagacttttc ctgaggcacc tgtttggaat ctggttttct cagcggcagc 1920 ttgacatgtg cacccttttg tattaaacac tgcaagggtg attgcagggg agcaggaaag 1980 ccatcctaaa ctcactactg agtacgattc agtatgttcc tgtggatgtc tgctgtgact 2040.
aatataaatt tcttgcagaa tcagctacac ttaattatgt tgctgataga caagcatcca 2100 cgcttcagct gggcactaag tgttttcatt gtaggatcag cagcaggtta aagactgaac 2160 ggttagtgaa gactaaatgt cttaagaggg tgcgatgtct aggttgggct tgtgacgttc 2220 ttagtggcct agcgcttctg gatggcacct tgagaagtga acttctagag aatctacatt 2280 taaaaggcga agcgtttaga aagcagagct agtctattct agttagctga tgcgaactaa 2340 aattctgtag tttcttaaga tggagccact gacgagatgt cacagtatag agcctgcagt 2400 ctcaactcat tgtgatccta atggtctggg tgattggatg gtttgagttg ttagggattt 2460 tgaagttttt cattttaatt gcatatcctg ggttggatgt tagaactaaa ggaaacccca 2520 ggaatattta cctgggtgtt acatttaata tttaatgtaa ctggtcctag caacatttaa 2580 gggggatttc tgaagcccaa ctccgggagg ctgtgggctg cacattttgc actgttttta 2640 tatacttgta ttcatatcct cttatcacct cagactcaga cacaaggcct tttacatgga 2700 aattttacaa attacttcca tttatgtaaa ataacgtcct gtgaccaagt tgtttaaatg 2760 gaaaataaag tgctttcttt aaggaaaaaa as 2792 <210> 31 <211> 9549 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:350243.2:2000MAY01 <220>

<221> unsure <222> 878, 1210, 8010, 8017-8018, 8030, 8032 <223> a, t, c, g, or other <400> 31 tgggcatgta ctgaccaatg tggcaggtct gagaacatag ctgaagctga aaataggaaa 60 gctgggggca aggaagagcc ttgaatcttg aggtgggacg ttgactctaa gatgttcttg 120 aaccagtggg agcctccgga gggaaaggag tggatgcaaa cccggttgag acatacgaca 180 gtggggatga atgggacatt ggagtaggga atctcatcat tgacctggta cgccgatctg 240 gaaaaggacc agcagaaact ggaaatgtca ggctcaaagg aggtggggat accggctccc 300 aatgctgtgg ccacactacc agacaacatc aagtttgtga ccccagtgcc aggtcctcaa 360 gggaaggaag gcaaatcaaa atccaaaagg agtaagagtg gcaaagacac.tagcaaatcc 420 actccaggga cttccctgtt cactccaagt gagggggcag ctagcaagaa agaggtgcag 480 gggcgctcag gagatggtgc caatgctgga ggcctggttg ctgctattgc tcccaagggc 540 tcagaagaag gcggctaagg catcccgcaa gtgtagccgg gttcccaaaa ggagaaggag 600 aacagctcat ctaagagcaa gaaggagaga agcgaagtga gctggtgtga cttgttccag 660 acaaatggat tcctggggtc ctccatgcca tgttcccatt gtggaaggac tggtgtgtgt 720 gtcagtatga tggaagtgca agggttgata caaggagctg tggcagccac ttgggagtat 780 agctattgag cctggggcag ctgctcaatc ctttgggaac tatcacggat cctagagtga 840 aggcgggaat gagtgtcgcc ttgctaacag aaagtcanat gtctgaatag gatggagtcc 900 ccttgtttcc acacccagca gtgctgccaa tacacctttt ggtgcccagt ggtcaacaat 960 gacatctcat ctccttgttg tagcagatca tggttcgtga ccccatcaga gtggggtgct 1020 caccactatg tgatgtggct ctggccacag agcctgagtg cttgggcccc tgtgaacctg 1080 gaactagcgt caaccttgaa ggcatcgtgt ggcaggaaac agaagatggg atgttggtgg 1140 taaatgtaac gtggagggaa caagacaata atgtaggtac acgtcctgtg acgtgcacac 1200 gacatgatgn tgggcacccc cgcaggttct gtgactcccc gaccagtgac ctggagaatg 1260 cgcaatggcc ggggtagagg caaacgcatg cgtcccaaca gtgatacacc tgtcaatgag 1320 acagccacag cctcgtgaca gcaaaggcac cgagtgacag cagctattca ctgggctagg 1380 agccaatagc aaaggccgtc ggggcagcca gaattcttca gagcaccgcc cacctagcca 1440 gcagcacttc tgaggatgta caaggccagc ccctcctcag ctaataagcg gatttacaaa 1500 cccctttcag acatggagct gaattctagc tcagaggact ccaaagggac caagcgtgtc 1560 cgtactaatt ccatgggctc agccactggc ccccttcctg ggacaaaggt agaacccact 1620 cttctggaca gaaactgccc ctccccccgt cctaattgaa ctgtccccac ccaaactgca 1680 acaagaagta caagcacatc aatggactta agtaccacca agctcatgcc catacagatg 1740 atgacagcaa gccgggaagc gggatgggga cagtgagtac ggagaggaac ctattctcca 1800 tgcagatctt gggagctgca acggtgcatc tgtctctaca aaaaggttcc ttgtcccctg 1860 cccgctcagc atacccccta agttcgactt gtagagcccc catagccctt cgtccttcaa 1920 gcaaatttca gcacaaaagg cctctgtaag aaaaagttga gtggggaagg ggacacagac 1980 cttgggggcc ttatcccaat gatggctctg atgatggacc ctcagtgatg gatgaaacaa 2040 gcaatgatgc ctttgattct ttagacagga agtgtatgga aaaagacaca atgtacaaac 2100 acctctagtt taaaaccgtg aaaagattcc attccaagag cctaaagtca gcccagtccc 2160 attgcccctg ccatcccccc acagcaaatc tacaccttcc agacagccac cttcactagc 2220 agcgagccca ggctcttcct caggcttgac cgccacagtg gcacaagcca tgccctacag 2280 tccccaactc aagcccattc agcccatagc ccactgttat gggagaacct ttcacagtca 2340 accctgcctt gactccagcc aaggacaaga aaaagaaaga caaataatag aaggaatctt 2400 caaaggaact tgtaagtcct ctgacccctg ggacaccctt gtcgagcaga tggtaagtca 2460 ttatagccca ttcagggaat cttcaggaaa tgggatgaaa atggaggggc tcctaaatgg 2520 ctcatcagac ccccaccaaa gccgactggc tagcatcaag gctgaagccg acaagatcta 2580 cagtttcacg gacaatgccc ccagcccttc cattggaggc agtagccgcc ttgaaaacac 2640 tacccctact cagcccctga ctcccttaca tgtggtgacc cagaatggag ctgaagccag 2700 ctcagtcaaa accaacagcc ctgcatactc tgacatctct gatgctgggg aggatgggga 2760 gggcaaggta gacagtgtca aatcaaagga cgccgaacag ttggttaaag aaggggctaa 2820 gaaaactctt tttccccctc agcctcagag caaagactca ccatattacc aaggctttga 2880 gagttactat tctccaagtt atgcacagtc cagccctggg gctctgaacc ccagcagcca 2940 ggcaggagtg gagagccagg ccctgaagac aaaaagggat gaggaacctg agagcataga 3000 agggaaagtg aagaacgata tctgtgaaga aaagaagccc gagctgagca gttccagtca 3060 gcagccctcg gtcatccagc agcgtcccaa tatgtacatg cagtccctgt actacaacca 3120 gtatgcctat gtacccccct atggctacag cgaccagagt taccacaccc accttctgag 3180 cactaacacg gcttaccggc agcagtacga agaacagcag aaacgccaga gcttagagca 3240 gcagcagcgg ggagtggaca agaaggcaga gatgggcctg aaggagcggg aggcagcact 3300 caaggaagag tggaagcaaa agccgtcaat tccaccaact ctcaccaagg cccccagcct 3360 gacagacctg gtgaaatcag gacctggcaa ggccaaggag ccaggggctg acccagccaa 3420 atcagtcatc attcccaagt tagatgactc ttcaaaactc ccgggccagg cccctgaagg 3480 ccttaaagtg aagctgagtg atgccagcca cctaagcaag gaggcctctg aggccaagac 3540 aggtgctgag tgtggtcgac aggcagagat ggatccaata ctctggtacc gacaggaggc 3600 agagccccgg atgtggacat atgtttatcc tgccaagtac tcagacatca agtcagagga 3660 tgagcggtgg aaggaggagc gggaccgcaa attgaaggag gaaaggagtc ggagtaagga 3720 ctctgtcccc aaggaagatg ggaaggaaag cacaagtagt gactgcaagc tgcccacgtc 3780 agaggagtct cgccttggga gcaaggagcc ccggccaagt gtccatgtgc ctgtgtcctc 3840 cccacttacc cagcaccagt cctacatccc ctacatgcac ggctattcct acagtcagtc 3900 ctacgacccc aaccacccca gctaccggag catgcctgct gtgatgatgc agaactaccc 3960 aggttcctac ctgccttcca gctactcttt ttccccatat ggcagcaagg tctcaggtgg 4020 tgaagatgct gacaaggcac gagccagccc cagtgtgact tgtaaatcca gctcagagtc 4080 caaagccctg gacatcttgc agcagcatgc cagtcactac aagagcaagt ctcccacgat 4140 aagtgataaa acttctcagg agagagatcg aggaggctgt ggggtggttg ggggtggtgg 4200 cagctgtagc agcgtcgggg gagcaagtgg gggtgaacgg agtgttgacc ggccccgcac 4260 ctctccttcc cagcgcctga tgtccacaca ccaccaccac caccacttgg ggtactcatt 4320 gctcccagca cagtacaact taccctatgc agcagggctt tcttctacag ccattgttgc 4380 cagccaacaa ggctcaactc cctcactcta cccacccccc aggaggtgag aatgacacca 4440 agtgcccgga taaagtcagc ttcacgggcc cggactggct tacccaagga ggtgctgaag 4500 gtgccgttta gacatcagtt aaatggtgtt gatcatcctg tttgccgttt ccaccatgac 4560 tgaaggcaga cccttggcta tctcacctcc accagacctc cggactacct gaccctacct 4620 cttcctcagg agctggagag ctggtactta gcaaaaatat ttattctctc agccacagtt 4680 atgactattg tggcctctgt ggagatgaag gcacgggaag caaccagggg aacatggcct 4740 cagcccagag aagccactgc tctgttcccc aagcccttgg tctgctgctg gagcagtacc 4800 agcccccccg cccaccaggg agggaccccc acccccaaga cactgggtaa ggtctgaaga 4860 cagcacagca gccatacccc tcaccatcat taccaccatc accagattct gcatctccct 4920 agtgctttgc accctgggaa ttggcagcat gtggaggaac tagaatctca ggaaagaaat 4980 tgggggttgt tttctacata attgtgaaaa caaggtcttc aaatgtggag acttctcccc 5040 atttacatga gcacatataa acgctcacaa cctagcctgg aaagggaaga ccaaggcatc 5100 tgccccaaca tggccttgag ctgcctgtga ggcagggggc aggggttcca acaccagcac 5160 agggctcccc agggacactg ggagcaagct ggtgctggag catgaatgac gtctgtgaag 5220 tagaacctgc gtccccacta agtcctgctg gcttcttatt ccccacactc cttgcccttt 5280 tcccttccct cctaacccct tggtgccttt gcccaggggg atccccacac tgggtcttgc 5340 ctcttctttt ccactgctgg gctcttaagc ctcagaccag ataaactagt attcccccca 5400 gcttggggag accttggagt ctgccaggtc accttagggc aaggcccaga aggcagcccc 5460 tgggagcacc cagcagttct tggagatgtc ctgtcatcta gccatctgat atcttcctca 5520 tttgaggcca cagatatata cagcccaatt cctctgtcta caagtacatg attttatata 5580 gctcagtcta taacctccat gtgggccaat ataagctgtg tttcttgggt aacacatatc 5640 cttgtttgag gggcccactg gccatgggag gttatttgtt ccttagaccc tggaataaca 5700 catccaagcc attacttatt agagtctcag aatgtactca gtggagctgt gctttgaggc 5760 agccaacatt tctctgctct ccttagaaat gcagtctccc aatggaagct ttatactctt 5820 tgtactggga aagtgaggat gatttggtag ctttattggg gtcatgtctt ccccaaggtg 5880 tggggagctt agcttacttg gcttttgagg tatcatccct ctgttctccc ctcctatctt 5940 tccatgaccc tctggattga gagagagaga taaagactga cagacaccag tgtaggctgg 6000 aaaagggagt gtgtgaccag agtgccaaaa gtgactagga gcaggaactt ggctccgact 6060 tcagtttgga aaactgggaa atacggggca cagctaagca caatgcccag tagtagttga 6120 tttccaagga ccctggaacc ctacacttga gaggcttagg gtcaccatct gctcaagagg 6180 atcccctctg atctacaggc cttttcccta ggtttctgcc tcctcgtttt tgttcaagtt 6240 gggttctgag tcctccccaa aaaccattgt tttagacctc ttggcagggg ccccaaaaca 6300 gcctccctca tacccatcat tccgtctgcc ttctgctgcc ctcatgggca gtgctctgag 6360 cagtgacctc cctttcctcc gtggaagtag ctagtgcaga caccgtcatc ccaccccacc 6420 tgagtcaccc caaccaagag gggtgacttg aatttcagcc tgattatgcc ctcctggggc 6480 tcctgtgagg tggagccaag gttcccttct tcttgttccc tgtattgttt ttaaatattg 6540 ttgtgtgttt tgtatctgtg gcactggcct gcagcatact ctgtatatat tgtaaaagga 6600 aaccgttagg agtaattttc ttttgcattg gggcaggcat ggccctgcat tcctgccctt 6660 tccactacat tctgtaacac agaggacgaa cttctgtatt aactggggca gccttgggtt 6720 ctccagaaga agaacaggtt tttcttttcc ttggtgaatt tttcttctta aacattttgg 6780 ctctttgatc ctcatatcca agttctcccc tgaagagtag gagctgctca gaagagcagg 6840 ttgaaagcca ccatgggcag atcctgatgc ctggccgggc ctagtcttcc ctctgaaata 6900 acatgaagca gcagctgtgg agattcttga caagtgctga gtgaaagatg ttgcttgcca 6960 cacctgctac atggtggatg gagataacat catggtgtgg agcttaccat gtggcatcca 7020 tgacctagtc agaggggatg agatgctcag caggggtcac tcacatgcgc tatcccaccc 7080 cacaaaatca taatgtgcat ggataaaatt tgctaccaag ggcacaagac caccagacca 7140 agcctgttta tgagccacac cactgcccag gccctcacag accattgctc acggggcttc 7200 ccatagagga gaagctaaag agggaggggg cctcatcccc agatagatca ggcaaggctt 7260 gggagagctg ctctttagga ttccacatca actacttcct cattttaagg tatggcagtt 7320 cccttcatcc ccttttcctg ccttgtacat gtacatgtat gaaatttcct tactcttacc 7380 gaactctctc cacacatcac aaggtcaaag aaccacacgc ttaggaaggg taagaggggc 7440 accctatgga aatgaaatgg gtgatttctt gagtctcttt tttccacgtt taaggggcca 7500 tggcaggact tagagttgcg agttaagact gcagagggct agagaattat ttcatacagg 7560 ctttgaggcc acccatgtca cttatccccg tataccctct caccatcccc ttgtctactc 7620 tgatgccccc aaagatgcaa ctgggccagt taagttgggc ccccataatt ctgggggcct 7680 ttgttgtttg ttttaattac ttgggcatcc ccaggaagct ttccaagtga tcttcctacc 7740 atgggccccc ctcctgggat caagcccctc cccaggccct gtccccagcc cctcctgccc 7800 cagcccaccc gcttgccgct tggtgctcag cccgcagcat tgggagcagg tcggctccac 7860 actggaggcc cgggctggag gggcagtgtt gctgttcata gattttgttc cattggcgtt 7920 gctctgttga atttaatttc aagtcttcct gattcttccc ttctgtaaaa gtgtacatta 7980 ccaagttcct tgttttttta tatatatatn tgggtgnnta tatatacaan cngtactctt 8040 tttgcctttg tacattcagg caagaagaga aaataaatct ttttaagaga caatcacaaa 8100 tctgtgaggg ctgctggtta tttctcctgg agtttgctgc tgagctgcct cttccttcct 8160 cccaattttc ctgttctccc tcagctctcc tgatcttcct ggccctgctc catatgcatc 8220 ctcagcttca ctttcccgtg gctgatggca agctgtggaa tccagtgtcc agactacctg 8280 ccttgtaacc cttttctgcc cagcattgtt ttctggcttg gccactggct tagcccagga 8340 gctttactct gtgcccctgg cctcccctct cttcaccttt agatttccat tcaccgaagt 8400 ggctttggac ccctgggtac tctgggacct gtttcctgga ggccctggct tgggacactc 8460 acctgagaaa actatgcagc tgggagctct ctgcctaaga gtttgcacta tttaaacctg 8520 cctgggagtt aggacggatg gttttaggaa tgaccggaaa aactacccct aaaactcccc 8580 cgacattcca gcctctagaa tgctctgatc cagagctcag tggatgattc ccagctggtg 8640 gactcctgtg gctaccccat caagacaaag ggctaggggt ttatgggtca agagtatttg 8700 atcagaattt taaagggtgg tatactctga aacacagccc aacctaaacc attgtttggc 8760 cgctttctct tttcctctac cttcctcatc cccacttttt tccctttctc tctacttcct 8820 cttcttaatt ggctttggaa ttgaaatata tttttaaatt atttgttgta tttattgaat 8880 aaagttttta atgtccctgt tcttaaaaaa aaaaaaaaaa aaaaaaaagt ttgggacact 8940 ggactcccgt gagctggaag gaacagattt aatatctagg ggctgggtat ccccacatta 9000 actcatttgg ggggtccagg gaccctgggc aatataagta ttctagctca gtgtcgtgga 9060 gatcatctac ccagtgctgg ggcttctgtg gacagtgcga ggacccacgt gaccctggag 9120 gagctggtcc aggtggactg aactcccggc atctttacaa gagcagagcg atgatcagca 9180 ttcctgccgc tgcttgctgg ggctcagcca tgggctgcac aggagccagt gtggcttcgt 9240 ggcccatgtg ggaacgcacc tgtctgttgg atgatgctgg gactccaaag gatttcacat 9300 actgcatctc cttcaacaag gatctgctga cctgctggga tccagcagga gaataagcat 9360 ggccccttgt cgaacttggg ggtgctgaat agcttggcga atgtcctctc acagcacctc 9420 aaaccaaaaa gacaccctga tgcagcgctt gcggcattgg gcttcagaat ggtgccacac 9480 acacccagcc cttctgggga tcactgacca acaggacacg gccaccatct gtgcaagtat 9540 gccaaaaca 9549 <210> 32 <211> 1818 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:445188.1:2000MAY01 <400> 32 gtcagctatt ttctacatgc ttcatttgca gtgtaatatt ggattgtatg agactttggg 60 ttttgtgtta atacctacag aaaatgttga tattttctct tagcaggctg tcaaccaggt 120 taggttcagg tcataagttt ctacccacat tctttgaact gtagttgtca ttttagttta 180 tttttcaaaa acttttgcag tacctttttg gtctgtcttg tgtgtgcctt gcagtgaaca 240 gtctggattt ggacagtggt ctgtctgtta gttcagtttc tcaagccttt gtcacactaa 300 taggattgga tttatgtatg tccagcttgg gaattattac aggaattaaa aacaactttt 360 tagagtgctt tcctgagctc tctttctatt tgttccccct tctacttttt gcttccctgt 420 ggctgctgtt tctatcctcc agccagagag ctagtgttta ttttctccat tgtgttacac 480 acttgtgcag ctgcaaccac catatccagg gcccaatggt aggaggtaga gaagaaaagc 540 aaaagggatt ggcctcatcc tcttacaacg atagttccat tgaatagaga gaaaggtttt 600 cctgcctcag agtgttggct gcactaggct tttgttactg tagtctggcc ctgttaccat 660 gggattgctt gcatgtgggg atacaggaga attcagaaaa gaaaaaaaga tttgctattt 720 ctacattctc cctgagcatt aagacttccc ttgcccattc ctcaattcaa agctaaggct 780 tcttctggag ctgcctctgt gggcggttcg ggagatacca aaggagaaaa agtaccactg 840 ttgatatggt ggtatttcaa attctggtct accctatttc acatgccttg tttacttttc 900 agagctgaca gattgctgct ccatgcattc tgtccagttt cctaagagag acagcttgga 960 gtatgcttaa tccatcttac ctgggactga aacagctgct tattttgccg ttaaaaatta 1020 catgcagttt actgcgtggc tccgggtttg tttgtctgtt tttcctcctt taataggttt 1080 attcagaaaa catgtccact gcaattaggg aggtaggagt ttggagacag accagaacac 1140 ttctactgaa gaattactta attaaatgca gaaccaaaaa gagtagtgtt caggaaattc 1200 tttttccact atttttttta ttttggttaa tattaattag catgatgcat ccaaataaga 1260 aatatgaaga agtgcctaat atagaactca atcctatgga caagtttact ctttctaatc 1320 taattcttgg atatactcca gtgactaata ttacaagcag catcatgcag aaagtgtcta 1380 ctgatcatct acctgatgtc ataattactg aagaatatac aaatgaaaaa gaaatgttaa 1440 catccagtct ctctaagccg agcaactttg taggtgtggt tttcaaagac tccatgtcct 1500 atgaacttcg tttttttcct gatatgattc cagtatcttc tatttatatg gattcaagag 1560 ctggctgttc aaaatcatgt gaggctgctc agtactggtc ctcaggtttc acagttttac 1620 aagcatccat agatgctgcc attatacagt tgaagaccaa tgtttctctt tggaaggagc 1680 tggagtcaac taaagctgtt attatgggag aaactgctgt tgtagaaata gatacctttc 1740 cccgaggagt aattttaata tacctagtta tagcattttc accttttgga tactttttgg 1800 caattcatat cgtagcag 1818 <210> 33 <211> 2198 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:244378.1:2000MAY01 <400> 33 gagattttgg aatctggtga tactgttgtt tattacacta gcctattaca ttttctttct 60 ttataataac tgtttatgtg agtttcattg aaaatcgtgg ctctattgct ttattcatgg 120 tttccacaac tctttttgta acaccttaat tttctctctt aggtattttc ctgttaaata 180 agatatcaaa agcatcaatc acaagacaga gaaaacgtat taggaaaaac ttgtactagt 240 atattctaaa ctgaaatgga aaaactcatt attcatattt taataaataa aactcccaaa 300 tgatcttgct aaattatccc actatttaga agtagaaaat aagagaagag tgctttcaag 360 gaaatttgtc atattctccc ttctatctag aagttgacaa tgaattgcaa taaaactaag 420 acataactga atgctgaaaa ataccatgga ttaatgttat ggcttcttta tttttgtata 480 tccattccca caaaattgaa tttaagatta ttaatgaaaa ttctatatta agtaataatg 540 cttgtattag taatgggcaa agaagtcttt ctttgttaca agtaaccgtt agtaaaagat 600 gtactttgac atttctgaag gttaaacctt atatgtaaat attgtaattt aaatatgatt 660 ggacagctgt taagttttcg gggagggaag cagatgccag cgttctctgc tgaaaagaac 720 aagatggcgc ttgacggacc acagcagatg gagctggagg aggaaaaggc aggcagtgga 780 ctttgccagt attatcttgt cccaggattg gagaactcca gggtccactg gcatattaat 840 tgggtggggg gaaagccaca aggaacagtt ctgaactcca ggtgcatttg cagctgattt 900 tgaatgataa gacccaaaac ctctggaggc ggcaggtgca cgggaatgaa ctaaatgttt 960 aaagtgtgcc ttattacagg aggagctaca gctgctccca ggaattagga ctccctgtgt 1020 acagggaagt agtccaggcc atgggtaaga agaaagtgtt ggtcaaggtg catctcaagg 1080 acaagtttgt catagactgt ggacaaaaat atcagcatca gtgatgtgac acaccagttc 1140 cttggtggtt ctaagaaatg gaggtatact ttgtgcacaa ggatccttac cccacaaggt 1200 ggactccttg gtgtcactgg tgtattgtgt agagaaagtg tcccagtatc tcagtcttat 1260 agaaatgatt gggtagacct ggataaggca gaatcacaga agcatcaaca gaagtgatct 1320 gacctgcctg ctaagcatcc cgagctcttt caaagcactg gggcattgca cagccccaag 1380 tggaatgcgt gcttaggaag agactgttgg ccctgggctc tggctcatta ttaggggctg 1440 gggtccctta atccaggtct ctggcttttg aatgggtcca gaaattcatt ggggaatttc 1500 tgtgatggcc agagaaaatg ctcatctgtc atcttcatgg atgaaattga ctcttttggc 1560 tcctcagagc tggaggggga tgctggaggg aacagtgaag tgcagcagat gatgctttcg 1620 agggtggctt tgaggccacc aagagtatca cgcacggttt atcacgggtg cgaatacgag 1680 atgagatacc tcgtgactcc ggctgtgttt gtcgcccagg ggcaccattg acagaaaaat 1740 tgaattccca acctgcaatg agtaggcctg gctggtcact ttgaagattc attctacaga 1800 aatgaaccct gacccagggg gatcaacctg agaaaaattg ctgagcttat gccaggagca 1860 tcaggctgaa gtgaagggca tgtgcaccag aaaccggcat gtatgccctg agtagcgagt 1920 ccatgtcact cagaaggact ttgaggtagt ccaaagtcct atctcatgcc aaaggacagt 1980 gaggaaaaac atgtccatca agaaactatg gaattgaggg cacatccttt gtgtgtatca 2040 catacaataa aactcagtgg gacaagcaaa aaaaaaaaaa aaaaaagttt tggggaggga 2100 tgatctgcta gtgtataatc aataactttt aacatttagc ttgtatttag taacatttca 2160 ttgtgttttg aaaaaaagta aaaaatcttt tgaagcac 2198 <210> 34 <211> 431 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:236574.15:2000MAY01 <400> 34 tataaatggc atttcttaat cttactgtat ttccatggaa taaaagtaat tcttatgcac 60 actgaagtta aaaaaaaata gcatttaaaa tttctgctca ggaaagtagt ataattttta 120 acataagtga gtttctcttt gtgttataat gtaatgaatt cttatacgca tatggagagg 180 aaaatgacat ttttctattt atggttttag ttcagccttt aagatacctt gatgaagacc 240 tggactattg aatggagcag aaattcacct ctctcactga ctattacagt tgcattttta 300 tggagttctt cttctcctag gattcctaag actgctgctg aatttataaa aattaagttt 360 gtgaatgtga ctacttagtg gtgtatatga gactttcaag ggaattaaat aaataactca 420 gaatgttatt g 431 <210> 35 <211> 3730 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:010100.20:2000MAY01 <400> 35 ctgaggttat tttggagggg aaggggggct tctagatgta ccttttatgc tttattaaaa 60 agtatattac ctattaaagt ttgtttaaat ctatttgagt taaaaatttg agatgtaccg 120 tgttttctaa acactgtctc cagtggcttc aaaaacacag gtactgttgg aaggcattca 180 cttttgagtg gcctttgacc tcagttttaa tctgattaat tcagtcattt tataatcttg 240 ctcttggtga gtttaaacta gatttggcta aaatagaggt gggagtgttg gcccttcaaa 300 gacagtttga tgtgttcaaa attgtagtgc atttaaaagg gttagacttc tgtgatattt 360 gtccaacgtc aatcagtact cattgcattt ttttacttag gctcttgagt gtgagtggac 420 tactggtatc atatgcaact tctgaactaa gttttaagag aatatgaatc atcagttgaa 480 taaaaacctg aacagtggtg aatgcaactt tgagacatat ggaaaggcta gagttggcat 540 ccaggggaca caaatagttt gaagactctg gtagtagaat gatgcaagtt tccttaaaat 600 taggcaatat ataatattga tactacgaaa ttcagtactt ttccggtagg agggggtcag 660 gtctcattgc ctttgtccgt accccaaaaa tatgaaaagg tggtctacaa gtttggttgt 720 ggcattgtca cagcagttgg ccccatgtta catttcctct tgtggcacct ctgagaggtg 780 tgtcttcatt acctcttgac aagagtatat tttgattgac tgctctatgt gcttgttgat 840 cttttatagc atttaaatca aacggtatcg agatggattg cgttatgaaa ccataatggt 900 cccagatgac gctagtgatg ggacagtacg acttcgtgga ctaccatttg gttgcagcaa 960 agaggaaata gttcagttct ttcaaggtac ctctagtatt agtcaaagtt tagtagtatt 1020 gtaattttat atttgtattg ttttactgtt tttaatttgt aaaacccatt tgattttgga 1080 acttttaagt ttaactatga tagtcttggt taatgtatta aaataatatg ctccagttaa 1140 tattcaatac agaatgtgta gaatatgtaa aacctaatta atgtgcagta acatatttga 1200 gaattgtgat gaaatgaacc gtgaattagt atatggagca tatatttgat tttgtagccc 1260 ttttttcatg taatataggt gggcttttag agtgtgtaat tacacagtgt tgtttacact 1320 aggtcgcaaa gaaatttatt taatccagta atatttgaaa aaatctttca tttgtattat 1380 ggggtgatgg gaaactaagc ttttttgttt tgttttgttt tgttttgttt agacttgttt 1440 taaatatttg attcagatgg gaatgtttca gcctttaaca ctgttcccct tgatggggtt 1500 atttgtcctt gggttaaagg gttggaaatc gtgccaaatg ggataacatt gacgatggac 1560 taccagggga gaagcacagg ggaggccttc gtgcagtttg cttcaaagga gatagctaga 1620 aaatgctctg gggaagatat aaggaaagaa tagggcacag gtggcgatgg agagtttggg 1680 atggtgttaa atttttattt ttgggggttg tgggtcacta ttgcttaaat gggggggtag 1740 ccataacatt tttctggggt agtttaaaag aattgataat tatctaaatt taacttggaa 1800 actacagatt tgggtgggga attaatgcta atagttaaat gtcaaaatta gggattgttt 1860 cccattttct cctgtaggga tgttgttaga taaaatgctt ttagtataaa tcaccctatt 1920 tcccttttaa aacaccctat tatgtactta aaaggagaca aagctaaaaa tatactttta 1980 tgaattgttt ttccgtgact aaattccttt ggtaaaactt aaatagtcgg aattaagttt 2040 gtaggtttaa actgttgact tacggtgtat tttaggcaat ttaaatttgg ggttatgtat 2100 ctagatgata gaaaaactta ctgcattttg cccatgtatc taatttacac taatacattt 2160 atgctggaaa ccctgcacct taaaaacatt tttaaaatag gtatattgga gaccttcaga 2220 agtagcagga ggtcaaacca aaggatttta tgatccaccc aagaagattg ccggggacag 2280 cgacccgggg accattatga tagacccatt aggaggaaaa aggggggtta ttatgggagc 2340 tgggccgtgg aagtatgtat gacagaatgc gacgaaggag gtgattggat atgatggtgg 2400 ttatggaggt tttgatgact atggtgggta taataattaa cgggtatagt ggaattaatg 2460 gttttgatga cagaatgaga gatggaagag gtatgggagg acatggctat ggtggagctg 2520 gtgatgcaag ttccaggttt ccctggtggt catttcgtac atattagagg gttgcctttt 2580 cgtgcaactg aaaatgacat tgctaatttc ttctcaccac taaatccaat acgaagttca 2640 tattgatatt gggaagctga tggccagagc cacaggagaa gcagatgtta gagtttgtga 2700 cacatgaaga tgcagtagct gccatgtcta aagataaaaa taacatgcgt aagtggtgtc 2760 tttggcacac aatcttattt cctaaacgtg aatttataaa ataagaggct ctaagatctg 2820 taggtaacgc ttggcagttg ttggggattt aaaaccattt gacctctata atggctttct 2880 gtgggcttta tatatcgctt gtactagtaa ttaataagca tactttgttt aatattacct 2940 taattgatct tttttacaaa gcttgtattg atgaatttta tccatcattc ctttctcccc 3000 tgttactctt tctttttttc ttaaagaaca tcgatatatt gaactcttct tgaattctac 3060 tcctggaggc ggctctggca tgggaggttc tggaatggga ggcctacgga agagatggaa 3120 tgcggcatgt aaagttttta aaatatgtca gggttagctg cttatcgatg agtctcaatt 3180 ttttttcttt tttcttttta aagataatca gggaggctat ggatcagttg gaagaatggg 3240 aatggggaac aattacagtg gaggatatgg tactcctgat ggtttgggtg gttatggtaa 3300 gtatctctag ttcagtttgt gttagtccgc atatgtagtg caaactttaa agtgcaggta 3360 ttacttttat tattttatgc agatatctcc tgctgagtga ttcttaatat ctttttctta 3420 aggccgtggt ggtggaggca gtggaggtta ctatgggcaa ggcggcatga gtggaggtgg 3480 atggccgtgg gatgtactga aaaccaaaaa caccaacata caagtcttga caacagcatc 3540 tggtctacta gactttctta cagatttaat ttcttttgta ttttaagaac tttataatga 3600 ctgaaggaat gtgttttcaa aatattattt ggtaaagcaa cagattgtga tgggaaaatg 3660 ttttctgtag gtttatttgt tgcatacttt gacttaaaaa taaattttta tattcaaacc 3720 acaaaaaaaa 3730 <210> 36 <211> 790 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:037940.6:2000MAY01 <400> 36 ggaagagtgt agaacagagt ttttctttct gagtgttctt tttaacttca gtgttagtgc 60 tagtagtaac cttatatgtc atctctccag aggtcttcat caaggattca catggcagtc 120 ctgatctgaa gggcatattt aaaatgtact tgtccagatt tcactgctaa agattatgat 180 tcagtaggtc taggatgggc ttcagccgtt tgggttgatt gtgatagcat acatgtcttt 240 agttgaggac tgctggtatt acctgcaatt ttgagataga gaaaagtgca ggaaaatctt 300 cctccaggat cactaaagct gagccctagc ttgttacctg tggaggcatt gagacatttg 360 ttcacagaaa gtacagtttg gatttttggt tttttttaga agaaagctca ttatttagaa 420 attttgcaat gttaactttt ctactaataa cacaatcatc ttcacttata tttttaggct 480 catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga tataacgtct 540 cagctggaga tcaattttgg agacccttgg ccgcccagga cgtggcggca ggggaggacg 600 aggtggacgt gggcgtggtg ggcgcccaaa ccgtggcagc aggaccgaca agtcaagtgc 660 ttctgctcct gatgtggatg acccagaggc attcccagct ctggcttaac tggatgccat 720 aagacaaccc tggttccttt gtgaaccctt ctgttcaaag cttttgcatg cttaaggatt 780 ccaaacgact 790 <210> 37 <211> 8059 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:228550.3:2000MAY01 <220>
<221> unsure <222> 461, 5072 <223> a, t, c, g, or other <400> 37 ggcagaggaa tctgttcctc aaggcattca cggacttcct ggccttcatg gtcctcttta 60 actacatcat ccctgtgtcc atgtacgtca cggtcgagat gcagaagttc ctcggctctt 120 acttcatcac ctgggacgaa gacatgtttg acgaggagac tggcgagggg cctctggtga 180 acacgtcgga cctcaatgaa gagctgggac aggtggagta catcttcaca gacaagaccg 240 gcaccctcac ggaaaacaac atggagttca aggagtgctg catcgaaggc catgtctacg 300 tgccccacgt catctgcaac gggcaggtcc tcccagagtc gtcaggaatc gacatgattg 360 actcgtcccc cagcgtcaac gggagggagc gcgaggagct gtttttccgg gccctctgtc 420 tctgccacac cgtccaggtg aaagacgatg acagcgttag nacggcccca ggaaatcgcc 480 ggacgggggg aaatcctgtg tgtacatctc atcctcgccc gacgaggtgg cgctggtcga 540 aggtgtccag agacttggct ttacctacct aaggctgaag gacaattaca tggagatatt 600 aaacagggag aaccacatcg aaaggtttga attgctggaa attttgagtt ttgactcagt 660 cagaaggaga atgagtgtaa ttgtaaaatc tgctacagga gaaatttatc tgttttgcaa 720 aggagcagat tcttcgatat tcccccgagt gatagaaggc aaagttgacc agatccgagc 780 cagagtggag cgtaacgcag tggaggggct ccgaactttg tgtgttgctt ataaaaggct 840 gatccaagaa gaatatgaag gcatttgtaa gctgctgcag gctgccaaag tggcccttca 900 agatcgagag aaaaagttag cagaagccct atgagcaaat agagaaagat cttactctgc 960 ttggtgctac agctgttgag gaccggctgc aggagaaagc tgcagacacc atcgaggccc 1020 tgcagaaggc cgggatcaaa atctggggtt tcaccgggag acaagatgga gacgcccgcg 1080 gccacatgct acgcctgcaa ggctcttccg caggaacacg cagctgctgg agctgaccac 1140 caagaggatc gaggagcaga gcctgcacga cgtcctgttc gagctgagca agacggtcct 1200 gcgccacagc gggagccttg accagagaca acctgtccgg actttcagca gatatgcagg 1260 actacggttt aattatcgac ggagctgeac tgtctctgat aatgaagcct cgagaagacg 1320 ggagttccgg caactacagg gagctcttcc tggaaatctg ccggagctgc agcgcggtgc 1380 tctgctgccg catggcgccc ttgcagaagg ctcagattgt taaattaatc aaattttcaa 1440 aagagcaccc aatcacgtta gcaattggcg atggtgcaaa tgatgtcagc atgattctgg 1500 aagcgcacgt gggcataggt gtcatcggca aggaaggccg ccaggctgcc aggaacagcg 1560 actatgcaat cccaaagttt aagcatttga agaagatgct gcttgttcac gggcatttgt 1620 tattacatta ggatcgtgct gaggctcgtg cagtacttgc ttctataaga acgtctgctt 1680 catcttccct cagtttttat accagttctt ctgtgggttt tcacaacaga ctttgtacga 1740 caccgcgtat ctgaccctct acaacatcag cttcacctcc ctccccatcc tcctgtacag 1800 cctcatggag cagcatgttg gcattgacgt gctcaagaga gacccgaccc tgtacaggga 1860 cgtcgccaag aatgccctgc tgcgctggcg cgtgttcatc tactggacgc tcctgggact 1920 gtttgacgca ctggtgttct tctttggtgc ttatttccgt gtttgaaaat acaactgtga 1980 caaggcaacg gcgcagcata tttggcaaac gtggacgttt ggaacgctgg tattcaccgt 2040 gatggtgttc acagttacac taaagcttgc attggacaca cactactgga cttggatcaa 2100 ccattttgtc atctgggggt cgctgctgtt ctacgttgtc ttttcacttc tctggggagg 2160 agtgatctgg ccgttcctca actaccagag gatgtactac gtgttcatcc agatgctgtc 2220 cagcgggccc gcctggctgg ccatcgtgct gctggtgacc atcagcctcc ttcccgacgt 2280 cctcaagaaa gtcctgtgcc ggcagctgtg gccaacagca acagagagag tccagactaa 2340 gagccagtgc ctttctgtcg agcagtcaac catctttatg ctttctcaga cttccagcag 2400 cctgagtttc tgatggaaca agagcccagg ctaccagagc acctgtccct cggccgcctg 2460 gtacagctcc cactctcagc aggtgacact cgcggcctgg aaggagaagg tgtccacgga 2520 gcccccaccc atcctcggcg gttcccatca ccactgcagt tccatcccaa gtcacagctg 2580 ccctaggtcc cgtgtgggaa tgctcgtgtg atggatggtc ctaagcctgt ggagactgtg 2640 cacgtgcctc ttcctggccc ccagcaggca aggagggggg tcacaggcct tgccctcgag 2700 catggcaccc tggccgcctg gacccagcac tgtggttgtt gagccacacc agtggcctct 2760 gggcattcgg ctcaacgcag gagggacatt ctgctggccc accctgcgcg ctgtcatgca 2820 gaggccattc ccccaggcct gtgtcttcac ccacctgccg tcattggcct ttgctgtcac 2880 tgggagagaa gagccgtcca gggacccatg gtggcccaca tgtggatgcc acatgctgct 2940 gtttcctgct tgcccggcca ccacccatgc cctccatagg gtgaggtgga gccatggtgg 3000 tgcgtccttt actcaacaac cctccaatcc ggatgctgtg ggaagggccg ggtcactcgg 3060 ataccatcat ccctgcggat gcaccgccgt accctgctca tctgggagtg gtttccctgc 3120 ggttacgtcc aagcccgcct gccctgtgtg ttggggctgg ctgagtttcg gtctccccat 3180 caccggccgc ctcgtggaga aggcagtgcc acgtgggagg acaaggccac gccggcagct 3240 tccagccctg ccgcagaagt gccaggatgt ccatcagcca ctcgccaggg cacggagccg 3300 tcagtccact gttacgggag aatgttgatt tcgcgggtgc gagggccggg agacagatac 3360 ttggctgtga tgagcagaca tcctctgtcc ccgtggaggg gtcaacacca aggtggtgtt 3420 cgtgcaccag aacctgtctc gggctgacgg gggtggcaca caggacacgg gtggatccca 3480 acaggcagca ccgcacctcc gcccgcctcc cgcactgcag ctccgcccgc cgggctctgc 3540 gtctccacgt cccctcgtcc catccccacg tcccctcatc ccgtcacctc gtccccacat 3600 ccccttgccc cgtcacctcg tcctcatgtc cccttgtcct gtcacctcgt ccccacgtcc 3660 cctcgtctca tccccacgtc ctctcgtccc cttgtcccgt ccccacatac cctcgtcccc 3720 atgtccccac gcaggggctc tccttcgtct taggatctgt tcagcgctgc tctgggtggg 3780 ttagcaaccc cagggctgct gtgataggaa gtccctgttg ttctccgtac tggcatttct 3840 atttctagaa ataatatttg acatagcctt aatggtcctt aaagaagaca tttcagtgtg 3900 agattcagac ttcagacgct gaaactgctg ccttttagga aagcaccacc aacgctggag 3960 gaggagccgg ccctcacgcc cgccccgcgc cacgctgtgg aacggggctc cggcaagtga 4020 aacccagagg gtgtttccga agtgtcttca ccattagtta tttttggaag ctcagatttc 4080 accaatttga ttgtataatc ttttacctat aaaatattta tttgaagtag agggtaaatc 4140 agcggtaaga acagtgaaca cagtggttgg gataaaataa ggtgacaaac atcaccccca 4200 aagatgaggg tagcgagcaa ctggcttgag cagacagaac gtgggaagac tccatetctg 4260 tcccgagggg ggcaggcgga gggggtcccc aggggccacc ctgcccttga ggtccttgtg 4320 ttggccgccc ttggtttggc agccctgtgc ccaacgcttg cccccgggca aacaagtggt 4380 gtgtgcgttt ttacagcccc tttttaggaa cccaaatatg ggcataaatg taacacctat 4440 agcgggggca gattctctgt atgtccagtt aacaaattat gggtaaggta tttgttgaga 4500 aatcttaaaa tggccttggc acggaagtat ttccatagct gttaatatct cttttatcca 4560 tttattgaac atactggtct aaattttaac aaataggttt ttaaacgctt tcatttttaa 4620 gtttatgaaa tttggggcac tttaacattt aaaattctgg tgagagtttt gactgaatgt 4680 tccaatctct gagtgtatac gcaaatttct acagattaga ttttatctct ctacacaccc 4740 ctcttctttt ctgggtattt ctggtggcag tgattagttg aacagcacat ttaaggcacg 4800 ataattgcta acaccttttc ctttaacaat ttggtggcaa tttcatctgc tttcctaatt 4860 gttttcattg ttaattgcca tccttcagcc ttaaaaatag aagattctca cgtgaaggtt 4920 tagtaagttg gggtcccagg ctttggccgg ttgttggaga ttgtccccca tggttacttt 4980 gtgaacacca ggttttaagc tgtgaaagtc actaaaactt ttacacactc ccaaaaggtc 5040 tttttaacaa attgctgtgg gaaattatta cnaatgaatg tgcctgatga tttggaacat 5100 agaccaaggc ggcactgaga taaaaaacag aacaggatgc agatagatcc ctcaggtgaa 5160 ctggacgttg ccagggtctt ccatgccaat gtttccacct cgcagtagtt agtatttact 5220 tgccattaaa ctaactttga agcaagtaat gtgcacactt tgagcacttt gttgagtttt 5280 gaaaaatctt atttgttgct gcaccagggt taataaataa ccaattttgt aattccagca 5340 tgttggtcca gagacaccgg tcactgattc acaccccagt ccctgccaca gaccggccac 5400 agaccgtctc agacacgcac agtgggcctg ctgccaatga ttcacacccc agttccctgc 5460 cacagaccgt ctcagacacg gcacagttgg gcctgtgggt agtgatacac ccacgagtcc 5520 ctgccacaga ccgtactcag acacgcaaca gtgggcactg cttgcattcg cgttgttacc 5580 ctgggctttt ggctccacgc gtcactccat agccactgtc caccatgggg gactatgcac 5640 cacaggaatc actcactata ttgtactatt gtacccacca caaagcgtgc aagctctcgt 5700 gcacactatg ccatgcacac aaacggtggt acaccaagtt gttgaagctc ctacacgcta 5760 tacacacgac acacgtgtac attgcaccaa gagcagtgtg tgacccctac agacattgca 5820 gaacgatgca gcggtgtttt acacattacc ccacagacca cgccccgtgt gacgatgctc 5880 ccctacacaa ttacattatt gcaccattat tcatggaacc agcggtaagg ttacctaaca 5940 cacgggacgc tggtgctaca gtgcagtgta ccacggtaaa agcacactgt acaacgctct 6000 ctacagggct tgcgtcctca cacactgtgt tatgccacag cagaagagca cgtatgagct 6060 tctactggca cacatgcaca cacatcacgc acatgtacat ttcactacac actgtgcagc 6120 ctcgcgtgca acacgggtgc actattttcc agtgtgtgta caacccaaac aaattgatgt 6180 tcccaagaac gtgtgtaaac ctacacggtt gcacactatc tgtacacatt gtgagctccc 6240 acacgttaca cacaggatgg cacatgggac acaccccaac acacgacaca cggactccct 6300 aacagcacca ctagacacac cacgatgtta caccaccaaa cgagctccca gacatgtaaa 6360 ccacacgtct cccaacaccc gtgagcttcc cacacatgta cacatgcaca tgtacgcacc 6420 accaacacta tggcggaagc tcctgcaggc gtgaatacac acatgcacac acatatacac 6480 acacggtgcc acaaacaagt gcacactgtc ctggtgtccc tggcaactgc atcctggcct 6540 ccttgctgag gggcccctgg tgagaggcct ctggatgggc atgggaagat gggctccctg 6600 gccccccagc ccatgcctcc ctgggatgaa gagtccccct cctggcagaa tgtctgggct 6660 ttgcagaagc aggccccggg agtgaagtcg cagcttcact tacaccaggc tgctctgtga 6720 gcaaggcttg gtgccctgga caaggccctt ccccctttag ggaggtccag ccttcgcaag 6780 ctgaaacctc ccctcggctc agccctatac ccgggcggcc acagaaggac tggccacacc 6840 cacgccgcac ctcaatccgt gcacgcgtcg gagcccccgc cagccttctg ccacgagcca 6900 gctgggaagg gccgcggctg cctaaagccc cagtcaaccc cagcctgtgt ctgagccaga 6960 cacaggcgaa ccagccaggc cacaccgttc tcgagggagg aggcccagat tcggccagcg 7020 tctccaacag gggtgaccat cccgctcggc ttgctgagcc gtttaaacca aatgtttaga 7080 ccaggctgtg gggactcccc tgagttgagc cttggccaag gggtccggtg ctgtcgccgg 7140 gaaacctccc agcccttgtt cttccaaacc cactcagctc aatgtgtttt gcactgaact 7200 agtactggat aatacaacca ctcttaattt~ aaatgttagt attaatttaa tttgacaaac 7260 tcagtgtcta acagctttga tatgcaggtc cttgcattcc ctacatttcc tttaggaagt 7320 tacccatttg taacttttaa aaacaggaaa aatatcaagt tggccaaaag ccaatctttt 7380 tgttttttta agctaaaggg tggggtgaac tgggaatgaa aacctttcct gatgtggtgg 7440 tctataagca gccttggatg ggatatggtt agaagtggtc atggaaagtg cgtggattct 7500 acttttggca gaaaaatcta aagatcaatt tatatagctt agatttttta ctttatcaag 7560 ggtatacaga aattttaata tgcatatatt ggtgtctgac ttaaaattat aatggtctgg 7620 gtcaccattt aaaatggtcg gttcattatg taattgtaat aaaagaaggt cttcaaaaat 7680 gtatttaagc atgaatgggt atccatagtt gtcatcatca taaatactgg agtttatttt 7740 taaaattatt aaacatagta ggtgcattaa tcataaatca gtctcccaca cagtaacatt 7800 taactgataa ttcattaatc agctttgaga aaattaacat tgttcaatta agaccaatct 7860 aacatttcag taaagtttat tttgtatgct tctgttttta actttttatt tctgtagata 7920 agactgactg gataatatta taattggact ttttcttctt agattatcta agcaggagac 7980 ctgaatctgc ttgcaataaa gaataaaagt ctgcttcagt ttctttataa agaaactcac 8040 acaaaaaaaa aaaaaaaga 8059 <210> 38 <211> 1423 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:027320.1:2000MAY01 <400> 38 gcggccggga cgatgcctgc gcgcagtcgc accgccccgc ctccactccg gctccccgcc 60 25!104 ccgggctccg cccccgccgc ttgaggcgct tcactccggc gaggcgggga gggccccgga 120 ctccgacggc ggctcggacg ccgacttcgg aggtgggtcc ggggagcccg actcggaccg 180 cggaggtgag cgggagctga ggctgaggag aggggagctt ggggggcgcc tgttgccaag 240 ggcagcggag gaggaaatgg caggtcctaa tcaactctgc attcgccgct ggactaccaa 300 gcatgtagct gtgtggctga aggatgaagg cttttttgaa tatgtggaca ttttatgcaa 360 taagcaccga cttgatggaa tcacattgct aacattgact gaatatgatc tccggtctcc 420 tcctctggaa atcaaagtct taggggacat taaaaggtta atgctctcag tccgaaaatt 480 gcagaaaata catattgatg ttttggaaga gatgggctac aacagtgaca gtaccatggg 540 ttccatgacc cctttcatca gtgctcttca gagtacagac tggctctgta atggggagct 600 ttccccatga ctgtgacgga cccatagact gacttgaatt ctgatcagta ccagtacatg 660 aatggtaaaa acaaacattc tgttcgaaga ttggacccag aatactggaa gactatactg 720 agttgtatat aatgttttat aatatttggg atttacatct ttcattatgg ttatagtcca 780 tgagcgagtg cttgacatgc agacctatcc acgactccca gatatattct tagacagcgt 840 tcctagaatc ccatgggccc tttgccatga ccggaagtat gtggcatgat tctgtgctat 900 atttggctcc tggttcttct tcttcacaag cacagatata tgggcagtgt atgggagaaa 960 ttacatcgag cctttgccat ttggagtggc tttggtatga ccctgactgg cgttcacaca 1020 tgtggagatt acatgtttag tggccacaca gtcgtcctaa ctatgctgaa tttctttgtc 1080 accgaatata caccaagaag ctggaatttc ttgcacactt tatcctgggg ttctcaacct 1140 ctttggaatc ttctttatct tggctgcccc atgaacatta ttctattgat gtgtttattg 1200 ctttttatat aacaacaaga ctctttttgt actaccatac tctggccaat accagaagca 1260 tatcagcaga gtaggagagc aaggatttgg tttcccatgt tctctttttt tgaatgcaat 1320 gttaatggca cagtacctaa tgaatattgt tggccatttt caaaaccagc aataatgaaa 1380 agactaattg gatgaatact atctttctaa tgaatttgtg att 1423 <210> 39 <211> 1594 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:321475.1:2000MAY01 <220>
<221> unsure <222> 280 <223> a, .t, c, g, or other <400> 39 ctcactcatt tctaaggagg actttaagca aatgagtcca gggatcatcc agcagctcct 60 cagctgctcc tgccacttac ccaaggacca acaagcaaag ctgccaccta ccactctgga 120 gaaatacggc tacagcacgg tggctgtcac ccttctcaca ctgggctcca tgctggggac 180 agcgctggtc cttttccata gctgtgagga gaactacagg cttatcttac agctgtttgt 240 gggcttggcc gtcgggacac tgtctgggga cgctctgccn ccaccttatc cctcaggttc 300 ttgtgtttac ataagcagga agccccagaa tttgggcatt tccatgaaag caaaggtcaa 360 tatttggaaa ctgatgggat taattggagg catccatgga tttgttcttg atagaacaaa 420 tgttttattc ttcttgtatc accaaatgac aagcagggcc tgtcattggt taatgggcac 4'80 gtgggtcatt cccaccatct tgcactcaac tctgaattaa gtgaccaggc aggcagaggc 540 aaatctgctt caactatcca gttgaaaagc ccagaagatt cacaggcagc tgaaatgcct 600 ataggccagt atgacagcct ccagacagaa aatgtaaagc cattagcttt gttagcaatc 660 atgattctgg ttggggacag cctgtcataa ttttgcagat ggcctagcca taggagcagc 720 cttctcatca tgcatccgag tccaggagtg accactacga ttgctatctt gtgtcatgga 780 aatcccacat gaaatgggag actttgccgt gctcttaagc tctggacttt ctatgaagac 840 tgccatcctg atgaatttta taagctccct aactgccttc atgggattat acattggcct 900 ttccgtgtca gctgatccat gtgttcaaga ctggatcctt cacagtcact gctgggatgt 960 tctaatattt atcccttggt tgaaatgctt cctgaaatga ctcattgttc aaacacaacg 1020 accctggcat gatgtttctg cctgcaaaaa ctttggattg atcctaggtt ggctttctct 1080 cctgctcttg gctatatatg agcaaaaata ttaaaatata agtgaggatc ttcaacatct 1140 ttcaaaaatg catttatata gtcttacttt gtttctttca ttgcactcta taatgatttt 1200 taaattaaga attttttatc ttaggcaaag tgtgtctctt tcaattcatt aacttattaa 1260 ttttataatg ccggtttatt ttttggaaac atataaatat cagactgtcc ttaattgaaa 1320 ttttgtcttt ggtttccaac accatgatga agctcttgct tttttaaaaa gtagttagta 1380 aattctgcat gaagttttag taaactttaa aaaatagatt ttttccctaa ggaaagaatg 1440 gtcttggtag aaatttacaa gtgggacagg atgcctgtcg ggggtaaaat caactgcaac 1500 ctttttgatg gttaattttt ttccctgtgc aattataaaa ctataagcaa gtcaagtgcc 1560 aagccaatgt tataaagact agttttaaaa aaaa 1594 <210> 40 <211> 2138 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:899552.5:2000MAY01 <400> 40 gtgaatatca agtctcccca accccacctg gaggggtttc atccagcaag agcttgcctt 60 ctgctcagca cactcctggg agtaacctat gagtgtcaca gctgcaactc cgaggtgcca 120 accaagccca gggctctggc ttcttctggg gtcaggccgc,tcttcagggt tcttcgcact 180 gcagtggtgg tgcaggtcac acccaaaggg atgagaagaa aaggaagtat gagcagcaag 240 gcacagggca gtcaagactc cagtcccccc ttctccccag ggacttccag agaagccaga 300 gggttcacac tctgtacctt cctgctcttg ctgaagtgcc ctgcagtctg tctgccagga 360 caaaagtttg gggctacaca ggctggccta acaatgccac aggtgctgat ttggagggcc 420 gagaggagtg atgcgggcac ttataaagag gagagaaagg aggagaggct caccctcacg 480 aggcttctga gaagggggtg aactgcagaa gtgcagaggg caggagagac ctcagcatct 540 acccagtatg aggagtgtat cagagctggg aaggtgattc cagagcaggg gaaaatgcaa 600 gctccactaa tacaaatgag gtgaggcaac cagtgcacag cgaggggttc cacaagaccc 660 aacaacctca caaatccaac agacgaccaa caatagctgg ggacatgctc aagacccaca 720 gagcaagtgc atgaagccag ggcaaggggc agcagtgagg acaaatctct ccatgagtac 780 tgtgggtctt agcctcaact cactaaaagg cctctagaga caataattaa aataaccagt 840 ggctcctcga ggaatggagg ctaatgagca aactgccaaa cttattctgg ctggaattgg 900 tggctgcttt ctatggaaca cacaagtctc aagaatggcc aatgaccact ctcactgggg 960 ggttgcagct ggcaactgga gggatgctca tatttaactg acttagaatt ggcttgtgtc 1020 tagcttggca tgatggtatt cccattgttt agtatttcaa tttcaacatc aaaataaagg 1080 ctggataagg gtgaatgagg aggtagctgc ctcacccaag acaagtcttc atttgaaagg 1140 gtggctaatt acattttcct taatttacaa attgtatttg acccactgtg tatttcttta 1200 aagttcgcac agagtttggg gtattcattt tcagaagaga aacgttattg gatctgcctt 1260 caccctaaat ccctaaatca gccagagttc ctggaaatga ccagggcagg ctgttgatca 1320 aagttcagag aaagtaagct caccttaatg tctccccagt tcctttgcca actcccctca 1380 tctactcccc agaggccagg gcccacctca tgcatctgca ggccacaccc catggtctat 1440 gccttcccat catcccctaa atataagctc actcagcctg tggacaaaag atctgaaaga 1500 cctatgtcca tggcagaatc aatggggact aatacctatt atgaaaataa agggctcctt 1560 ctcttccagg aatcagcact tggaacaggg gtcaacataa tatccatcaa ttggtcaacc 1620 aacaaaatga tttattgaga acccattgtg tgctcagcat ttaactcaaa gaatcaaaac 1680 acagacatca agtatgggtt tttagagaga catgggatat gtggtgaggg gttctcgtca 1740 aatcgtgtta ctgcaactac tgtatttcca agccttacct ttgggccctg aagcaatcta 1800 tctgtagctg ttcttgcact agctcctctt tcccccaccc ctgatccctt ggcctccaga 1860 ctgaatgttt gggctcaaca agacaaaatg tttggctcct aagtctcagc tggagacaga 1920 ttacattcaa ctgagcaaca gaatttgttc tatggggcag caataaaaat actagtttgt 1980 aataaccttt tatgttcttt aaagactcct tagagtgttt gttaaagaaa gataatttta 2040 acaacagtaa ataagataaa atatctctct tgacaagaaa gacctcttgc tgcaacttct 2100 taaccaagat acaaaatact tccttaaaaa gtccatgc 2138 <210> 41 <211> 1345 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1071848.1:2000MAY01 <400> 41 ggcgggaagg cgccggccgc taagaagccg aaagatgtcc aggtcgggcg cggcggctga 60 gaaggcggac tccagacagc gaccccagat gaaggtaaat gaatataaag aaaatcaaaa 120 catcgcttat gtgtctctga gaccagcaca gactacagtt ttaataaaaa cagctaaggt 180 ctatcttgcc cccttttcac tcagtaatta ccagctagac cagcttatgt gccccaaatc 240 cctatcagaa aagaattcta acaatgaagt ggcgtgtaag aagactaaaa taaagaaaac 300 ttgcagaagg attatacctc caaagatgaa aaacacatct tccaaggcag aatccacgct 360 gcaaaattca tcctcagctg ttcatactga aagtaacaag ctacaaccca agagaacggc 420 agatgcgatg aatctcagtg ttgatgtgga aagtagtcag gatggagaca gtgatgaaga 480 taccacacca tccctggatt tttcggggat tgtcacccta cggaaggaag agactgaaga 540 acatatcaga aaacgcagac ttttttgctt ctcttcagtt gtctgagtct gctgcaagac 600 tccgtgaaat gatagagaag agacagcctc ctaaatccaa aagaaagaag cctaagagag 660 aaaatgggat tggatgtaga aggtcaatgc gattactaaa agttgatcct tcgggagttt 720 cattaccagc agctccaaca ccgccgacat tagtagcaga tgaaactcct ttgttacctc 780 ctgggccttt agaaatgact tctgaaaatc aagaagacaa caatgaacga tttaaaggat 840 ttctgcacac atgggcagga atgagcaagc caagtagtaa gaacactgag aagggattat 900 ctagcattaa aagctaccaa agccaattta aatggcatgg tcattagtga agataccgtt 960 tacaaagttt accacaggcc caatattctc tatggctctc catccatcag aaactagaac 1020 tttggtagca gttgggccca aatttgggca agttggactt tgtgatttgg taagttatta 1080 aatttcttga atatattata gtttgactaa agcaaatagg ctggaagaga ataggctaga 1140 gccatgtgtt tataaatgtt gcgtgagact tacaattttg ggctttatga tgctttatga 1200 ttccaaattt tagaaatctg gaagaattta aatttgcttt atagaacttt aatattttta 1260 gcttgaatat cattaaccat ctggtcataa attaactgcc agaaaacttt gttacacttt 1320 gtgtgatctt ttcacatata cattt 1345 <210> 42 <211> 4707 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1072337.2:2000MAY01 <220>
<221> unsure <222> 994, 3721, 3729 <223> a, t, c, g, or other <400> 42 ttttctatat gatcagaaga gcagctactg tgattcctgg gctaatgaag cctagacccc 60 agctggattg gaagcaaagg cctttccttc actgggaaag gtgctgctgc tacccatctc 120 attattctaa gagtgattga gaatagaggg gctgaaggga aacgaaagta ggagaatgtt 180 ggccagagct agtagagaaa gaacgtaata ttgagaaagc agacatcagt gctaggtgag 240 gtgctttctt tagagagctg tgtgtataga ctggggagga gtctgtctgg ggacaggaat 300 gctgattcct tttttttccc tgggcagaat cctaatgtac ctggctagct ggtggtgagt 360 aggggctttg gggccaactt ggtgggctcc ccaaggaaac ccctttgaaa ccaatggatg 420 cattcacggg ctcgggtctc aagaggaagt tcgatgatgt ggatgtgggc tcatcagttt 480 ccaactcaga tgatgagatc tccagcagtg atagtgctga cagctgcgac agcctcaatc 540 ctcctaccac tgccagcttc acacccacat ccatcctgaa gcggcagaag cagctgcgga 600 ggaagaatgt acgctttgac caggtgactg tatactactt tgcccggcgc caaggtttta 660 ccagtgtgcc cagccagggt ggtagctctc tgggcatggc ccagcggcat aactctgtac 720 ggagctatac actctgtgag tttgcccagg aacaggaggt gaaccatcga gagattctgc 780 gtgagcacct gaaggaagag agactccatg ccaagaaaat gaagctgacc aagaatggga 840 cagtggagtc ggtggaggct gatggcctga cgctggatga tgtgtcagat gaagatattg 900 atgtggaaaa tgtggaggtg gatgattact tcttcctgca gcctctgccc accaaacggc 960 gacgggccct gctgagggct tctggggtcc accngtattg atgctgaaga gaagcaagaa 1020 cttcgagcca tccgcctgtc acgggaagaa tgtggttgtg actgccgact gtattgtgac 1080 ccagaagcgt gtgcctgcag ccaggctggg gattaaatgc caggtcagtg gatcgcatgt 1140 cctttccatg tgggctgctt cccgggatgg ctgtgggaac atggcaggac gcattgaatt 1200 'taatccaatc cgggtccgga ctcattacct ccacaccatt atgaagctgg agctggagag 1260 caagcggcag gtgagccgcc cagcagcccc agatgaggag ccctccccga ctgccagttg 1320 cagcctgaca ggagcacagg gctctgagac ccaggacttc caggagttca ttgctgagaa 1380 tgagacagca gtgatgcacc tgcagagtgc agaggaactg gagcggctca aggcagaaga 1440 agattccagc ggctctagtg ccagcctgga ctcgagcatc gagagcctgg gtgtgtgcat 1500 cctagaggag cctctggctg tccccgaaga gctgtgccca ggccttacag cccccattct 1560 catccaggct cagctgcccc caggctcctc tgtcctgtgt tttaccgaga actcagacca 1620 cccaactgcc tcaacggtga acagcccatc ctacttgaac agtgggcccc tggtctatta 1680 tcaagtggag cagaggccag tcttgggagt gaaaggagag ccttggtacg gaagaaggct 1740 cagcctcttt cccaaaggag aaggatctga atgtcttctc tctccctgtt acctcactcg 1800 tgggcttgta gctccacaga cccagctgcc ctctgtaaat cagaggtggg gaaaacaccc 1860 accctagaag ctctattgcc cgaagattgt aagccctgag gagcctgaaa atgaagactt 1920 ccacccttcc tggtccccct caagcctccc cttccgcacg gacaatgaag agggctgtgg 1980 gatggtgagg gaggtcccac gcagaatgag gatcggcccc cctgaagatt cttccattag 2040 aactccctct ggcagtgtgg acaggcgcta gaggtcctgc ctcttaccca ttctctattt 2100 attcccttat tttatctaac accatttcaa aacaaaactg tagaagcagc tgcttgctcc 2160 cccagtgatt attttattgg ggtctttggg gaatgggtgg gaaaggattg tttgagtatt 2220 ttttaaaagg gaaacagtac caaggagacc agccctacct tgatctgggg atagtcttgg 2280 ggcaaagaaa gctgcgtagt gcgtgaacat taagctttct gggccacttt gaacaaagaa 2340 ctaggatctc acaggaaaag ctgggtaact caagcagcta ttctttctgt agggacccag 2400 aacacgagaa tttgaagagc atggcaaagc cctttctctc ccaagcccca ggcagagtac 2460 aagctcattt ttctcggtgg gttattctga tatcccattt tggtgtgtca taatacttca 2520 aactggaaag tcacctggtc gagtctaggg aggagggagt gggaagggtc tctgcttctg 2580 tacaaaatct ccaggattta caaaaatgta acctgccttc cttcaatccc atatttgggt 2640 aaataaagtt aatatttgac atgtttggtg ttctctgacc tgttccccac actggggata 2700 tcctggtctg taacttgaat tgtttcttcc acatgttctt aagtactaga gttaaacttg 2760 tctatgtgtc ttttttctct ccatcccttt tttccttcgg agaaagagct ggattgggct 2820 ggggatatgg tataacgagc ctgagccttt ctgtacgtgt ccgaccatta gcactgtcag 2880 gcagctttcg gctggggctc acccatccca taggaggcct atgtggagca ttaactgtgg 2940 ccaaaggagg cagcgggaac aggctgcttg ctatctggaa agatgacata tttgtgccat 3000 gcttgttttt tcacccaggt ttttccctct ttgtgagatc tgagctttag tggaatgtag 3060 aatgtggcaa tcttaaggtc accaatcagt ttttgttctt ttttcctgga tctaccctca 3120 tggtcgtttt caacatagcg ggttagagtt cttatactgt tccagttcaa ttccaagaat 3180 tgcaaatgtt tattggaccc ctccatcttg atgatatata aaaattggaa gccaaaccag 3240 ttcttaaatg ctacatgcaa ctcccagatt ccaaaggatt caagttctaa ttataacctt 3300 tgaagcgtat agaatggaac tcattcagtt tgattcagtt cttacctctg tcaggaggga 3360 atacagttcc tgttcatcct gtgttctaag atctccattg aacagcactg atttcctttc 3420 attaggcaaa gtgatctttg tctctgttct aaaatgggag ggcagtaggg gagcaaaacc 3480 tattcttctc aagcatccct ttacaccata ctttacttct gggtatgggt ttattaacca 3540 cacacacaca caaaagtgaa aaactgtgtt gggggggaga cactactcct actgtatctt 3600 cgctccataa agccttatct ggatgggata tataagggcc tgggtgtctt accagaaacc 3660 catcaccgta atgtcgccag ccagccattg tcacccgctg taaaggtctt cgtaaactcc 3720 ntggaagcnc ctgagaaagg gaatttgtaa atttaataca cataacattt tttagttcat 3780 tctgtggttt cctatttgtt ccagtttttg cttggtttta gtttggaggg gaacttaagt 3840 acacagatcc ttaatctctc cccatcccct agcctcacaa aacacagttg agagtctttt 3900 taagtacctg agctctcgaa ggttacccag aactggaact agactcccct accttagact 3960 gggtaccctc aaaacacagg actgaagctt aattggggaa tttggcttta tgggagaaaa 4020 ggaatctttt tcacaagttt gtgtcggaaa ggggagggtg aggtttgccc actgtctctg 4080 caggaaaggc tccggcttaa atctagggaa gtaggattcc agctgcacga tgagggaaca 4140 cattagcttt tgggatcaaa ccaggaatat gaatctgtta attatttaag gctcattgcc 4200 aacccacaag atatgtttct gaaaacctgt agtttcttaa tttaagtcca tccccttcat 4260 taacgctaca gttgtgactc acactgatcc caaaactttt aagtgctaaa tattaacatt 4320 tagcattaac tgtcttgtca agcgaaaggc ccttctctac aaccctagtc ccatcctcac 4380 cttctggtgc ctaccctgag ttggacagaa ttcctagcct catgggttgc ctagggaaag 4440 ctaggcctct gatcataaga agcaaatagc tttcagtccc agtctaggcc tagataaatg 4500 actcttatta ccacaaccct tattattttc caatttcctt tctcacatac tgtacacagg 4560 tagtattttc aatgtgaatc caaagcttgt ctggttctct gaaaataatt tttttcccct 4620 ttaggttctt tacattgtga taatgctgta tttaaagaga atatttaaat gtaatattaa 4680 agaaatattc aaaagaaaaa aaaaaaa 4707 <210> 43 <211> 1069 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:251489.5:2000MAY01 <400> 43 gaattcttgg aaacttagtc agctgttact taagagttac gtattatcct atcattatgt 60 attaatatta attttttcat acacatgtcc atgcagaaca tattaggtat cttggtgtag 120 aaaacactaa tgttgaaatg aactaaattc caatctttta gtattctccc agtttagtat 180 cataaacttt tgtatctttt ccatgacctg cctttcatta gaggccttcg aggaagaggc 240 ccacctcctt catgggcctc tgagcctgaa cgcccatcca ttcttagtgc atcagaactg 300 aaggagcttg ataaatttga taacctagat gctgaagctg atgaaggttg ggcaaggtgc 360 taagatggaa gtagattata cagagcaact gaatttcagt gatgatgatg aacaaggaag 420 ttacaggcct taaagagaat aaccagtgag gatcaaggtt caaaagcctc tgaaaacaac 480 ggaaaacaaa aaagaaacag atgaagtttc caacactaaa tacatcttcc caaatacctg 540 cccaaaccat cagtagcaaa agttccctat gggaaaagga ccttcattta atcaggaacg 600 tggaacatct tcacatctgc caccacctac caaagttgct tgcacagcag catccacctc 660 cagatcgaca ggcagtacct gggaagacca ggcccctttc cctccaagca gcaaagtagc 720 tgatgaagat gaaatattgg aagcaaagac gaagacgaca atcagaaatt tctgcagcag 780 tagaatcgtg ctcgtaaacg gcgtgaagag gaagagcgaa gaatggaaga acaaagcgaa 840 ggcagcttgt gcggagaaac tgaaacgatt ggctgacgaa gcttggcatc ctggaaaaac 900 aaccatctcc agaggaaatc agggaaaggg agcgtagtat aaaagaacgg gagcgtgtag 960 aaagaacttg aaaaagaaca agaacaggag cgagagaagg agagggaaaa agacagagag 1020 tagacagcag gaaaaggaga aagagctgga gaaggagcag gaaaaacaa 1069 <210> 44 <211> 4375 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:902018.107:2000MAY01 <220>
<221> unsure <222> 179, 4314 <223> a, t, c, g, or other <400> 44 cttccagttg tcttgaacag cctggcagtg tcagggccga gtgggggttt ctccccactg 60 tccggcaagc gtcggtcagc cgaacactgt gtgcctggtg gtgtgtgttc acatgtgtgc 120 gtgcgtgtgc ccggcagagc agcaaacagc tgcgcccgag agctgtggcg ctttccctnc 180 ctatggaagt tccttttatg cgttggagga aaaacatgtt ggcttttctc ttgacgtggg 240 agaaattgaa aagaagggga aggggaagaa aagaagggga agaagatcaa agaaggaaag 300 aagaagggga agaaaagaag gggaagaaga tcaaaaccca ccatgcccca ggctcagcag 360 ggagctgctg gatgagaaag agcctgaagt cttgcaggac tcactggata gatgttattc 420 gactccttca ggttatcttg aactgcctga cttaggccag ccctacagca gtgctgttta 480 ctcattggag gaacagtacc ttggcttggc tcttgacgtg gacagaatta aaaaggacca 540 agaagaggaa gaagaccaag gcccaccatg ccccaggctc agcagggagc tgctggaggt 600 agtagagcct gaagtcttgc aggactcact ggatagatgt tattcaactc cttccagttg 660 tcttgaacag cctgactcct gccagcccta tggaagttcc ttttatgcat tggaggaaaa 720 acatgttggc ttttctcttg acgtgggaga agatcaaaga aggaaagaag aaggggaaga 780 aaagaagggg aagaagatca aaacccacca tgccccaggg ctcagcaggg agctgctgga 840 tgagaaaggg cctgaagtct tgcaggactc actggataga tgttattcaa ctccttcagg 900 ttgtcttgaa ctgactgact catgccagcc ctacagaagt gccttttaca tattggagca 960 acagcgtgtt ggcttggctg ttgacatgga tgaaattgaa aagtaccaag aagtggaaga 1020 agaccaagac ccatcatgcc ccaggctcag cggggagctg ttggatgaga aagagcctga .1080 agtcttgcag gagtcactgg atagatgcta ttcaactcct tcaggttgtc ttgaactgac 1140 tgactcatgc cagccctaca gaagtgcctt ttacatattg gagcaacagc gtgttggctt 1200 ggctgttgac atggatgaaa ttgaaaagta ccaagaagtg gaagaagacc aagacccatc 1260 atgccccagg ctcagcaggg agctgctgga tgagaaagag cctgaagtct tgcaggactc 1320 actgggtaga tgttattcga ctccttcagg ttatcttgaa ctgcctgact taggccagcc 1380 ctacagcagt gctgtttact cattggagga acagtacctt ggcttggctc ttgacgtgga 1440 cagaattaaa aaggaccaag aagaggaaga agaccaaggc ccaccatgcc ccaggctcag 1500 cagggagctg ctggaggtag tagagcctga agtcttgcag gactcactgg atagatgtta 1560 ttcaactcct tccagttgtc ttgaacagcc tgactcctgc ,cagccctatg gaagttcctt 1620 ttatgcattg gaggaaaagc atgttggctt ttctcttgac gtgggagaaa ttgaaaagaa 1680 ggggaagggg aagaaaagaa ggggaagaag atcaaagaag gaaagaagaa ggggaagaaa 1740 agaaggggaa gaagatcaaa acccaccatg ccccaggctc agcagggagc tgctggatga 1800 gaaagggcct gaagtcttgc aggactcact ggatagatgt tattcaactc cttcaggttg 1860 tcttgaactg actgactcat gccagcccta cagaagtgcc ttttatgtat tggagcaaca 1920 gcgtgttggc ttggctgttg acatggatga aattgaaaag tacaaagaag tggaagaaga 1980 ccaagaccca tcatgcccca ggctcagcag ggagctgctg gatgagaaag agcctgaagt 2040 cttgcaggac tcactggata gatgttattc gactccttca ggttatcttg aactgcctga 2100 cttaggccag ccctacagca gtgctgttta ctcattggag gaacagtacc ttggcttggc 2160 tcttgacgtg gacagaatta aaaaggacca agaagaggaa gaagaccaag gcccaccatg 2220 ccccaggctc agcagggagc tgctggaggt agtagagcct gaagtcttgc aggactcact 2280 ggatagatgt tattcaactc cttccagttg tcttgaacag cctgactcct gccagccgta 2340 tggaagttcc ttttatgcat tggaggaaaa acatgttggc ttttctcttg acgtgggaga 2400 aattgaaaag aaggggaagg ggaagataag aaggggaaga agatcaaaga agaaaagaag 2460 aaggggaaga aaagaagggg aagaagatca aaacccacca tgccccaggc tcaacagcgt 2520 gctgatggaa gtggaagagc ctgaagtctt acaggactca ctggatagat gttattcgac 2580 tccatcaatg tactgtgaac tacgtgactc attccagcac tacagaagtg tgttttactc 2640 atttgaggaa cagcacatca gctttgccct tgacatggac aataggttct ttactttgac 2700 ggtgacaagt ctctatctgg tcttccagat gggagtcata ttcccacaat aagcagccct 2760 tactaagccg agaggtgtca ttcctgcagg caggacctat aggcgcctga agatttgaat 2820 gaaactatag ttccatttgg aagcccagac ataggatggg tcagtgggca tggctctatt 2880 cctattctca gagcatgcca gtggcaacct gtgctcagtc tgaagacaat ggacccacgt 2940 taggtgtgac acgttcacat aactgtgcag cacatgccgg gagtgatcag tcggacattt 3000 taatttgaac cacgtatctc tgggtagcta caaaattcct cagggatttc attttgcagg 3060 catgtctctg agcttctata cctgctcaag gtcagtgtca tctttgtgtt tagctcatcc 3120 aaaggtgtta ccctggtttc aatgaaccta acctcattct ttgtgtcttc agtgttggct 3180 tgttttagct gatccatctg taacacagga gggatccttg gctgaggatt gtatttcaga 3240 accaccaact gctcttgaca attgttaacc cgctaggctc ctttggttag agaagccaca 3300 gtccttcagc ctccaattgg tgtcagtact taggaagacc acagctagat ggacaaacag 3360 cattgggagg ccttagccct gctcctctca attccatcct gtagagaaca ggagtcagga 3420 gccgctggca ggagacagca tgtcacccag gactctgccg gtgcagaata tgagcaatgc 3480 catgttcttg cagaaaacgc ttaacctgag tttcatagga ggtaatcacc agacaactgc 3540 agaatgtaga acactgggca ggacaactga cctgtctcct tcacatagtc catatcacca 3600 caaatcacac aacaaaaagg agaagagata ttttcggttg aaaaaaagta aaaagataat 3660 gtagctgcat ttctttagtt attttgaacc ccaaatattt cctcatcttt ttgttgttgt 3720 catggatggt ggtgacatgg acttgtttat agaggacagg tcagctgtct ggctcaatga 3780 tctacattct gaagttgtct gaaaatgtct tcatgattaa attcagccta aacgttttgc 3840 cgggaacact gcagagacaa tgctgtgagt ttccaacctc agcccatctg cgggcagaga 3900 aggtctagtt tgtccatcac cattatgata tcaggactgg ttacttggtt aaggaggggt 3960 ctaggagatc tgtccctttt agagacacct tacttataat gaagtacttg ggaaagcagt 4020 tttcaagagt ataaatatcc tgtattctaa tgatcatcct ctaaacattt tatcatttat 4080 taatcctccc tgcctgtgtc tattattata ttcatatctc tacactgcaa attttgggtc 4140 tcaattttta ctgtgccttt gtttttacta gtgtctgctg ttgcaaaaag aagaaaacat 4200 tctctgcctg agttttaatt tttgtccaaa gttaatttta atctatacaa ttaaaacctt 4260 ttgcctatca ctctggactt ttggattgtt tttcacattc agtgttataa tatntgatta 4320 tgctgattgg ttttggtggg tactgatgcg aattaataaa aacatttcat ttcaa 4375 <210> 45 <211> 3220 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:220495.1:2000MAY01 <220>
<221> unsure <222> 703, 2052 <223> a, t, c, g, or other <400> 45 acaggctcgg ggccagccgg gcgcgcatcc ccgggcgccc tgcgcggtgg agagcttggc 60 gggctgcggg tgccgcagga caggagtgga caaagcaaga tggcagggat cttagcctgg 120 ttctggattt agaggttttg gctcccgcac aatgtcacct gggcggacct gaagaacacg 180 gaggaggcca ccttcccgca ggctgaggac ctctatctcg cttttcccct ggccttctgt 240 atcttcatgg tgcggctcat cttcgagaga tttgtagcca aaccgtgcgc catagccctc 300 aacattcagg ccaatggacc acaaattgct ccgcccaatg ccattctgga aaaggtcttc 360 actgcaatta caaagcatcc tgatgaaaag agattggaag gcctctccaa gcaactggac 420 tgggatgttc gaagcattca gcgctggttt cgacaaagac gcaatcagga gaagccaagc 480 acgctgacga ggttctgtga gagcatgtgg agattttcat tttaccttta tgtatttacc 540 tacggagtca gattcctgaa aaagaccccc tggttgtgga atacgaggca ttgctggtac 600 aactacccct atcagccact cacaactgac cttcactact attacatcct ggagctgtcg 660 ttttatgggt cttggatgtt gttctcagtt cactggatat canaaagaat caggacttgt 720 ggcgattaat gttccctgca ccaccttgta tctattttct tgattacctt ttcatatgtc 780 aacaatatgg cccgagtagg aacgctggtc cttggtcttc atgattcagc tgatgctctt 840 ctggaggctg ccaaaatggc aaattatgcc aagtttcaga aaatgtgtga tctcctgttt 900 gttatgtttg ccgtggtttt tatcaccaca cgactgggta tatttcctct ctgggtgtta 960 aataccacat tatttgaaag ctgggagatc gttggacctt acccttcctg gtgggttttt 1020 aacctactgc tattgctagt acaagggttg aactgcttct ggtcttactt gattgtgaaa 1080 atagcttgca aagctgtttc aagaggcaag gctgggaagt ggaacccttt acatgtgtcc 1140 aaggatgatc gaagtgatat ttgagtctag ctcagatgag gaggagtcag aacctccggg 1200 aaagaatccc cacactgcga caaccaccaa tgggaccagt ggtaccaacg ggtatctcct 1260 gactggctcc tgctccatgg atgattaatt acttcaaaac ttacaagtcc caaggcaaag 1320 tgaactattt gttcctggaa gtatttaata agttgcaaat gccagttcct ttcataatat 1380 ctcagcacca gaaacaaaaa ttaagattat caaacgcatt ttgaatacgt gcactgccat 1440 gtgtcctgtc tgtgcactga agacgaatta ccattctctc tttgtaggca tgctgtatgt 1500 aatttgacac aagggaacag tatttgcatt tgtactggtc ttagaatatt atttattttt 1560 tttgtatttg taaatctgtg gacaaaagag ggtttcctca ctccttttac tcactggggc 1620 tcatgacagt gaaggagatg ctccatctgg cttctccccc tttctcttgc tgtagtccaa 1680 tgtgctatga gcatcagctt actttgtcac ttagagcaag caaaacccag tgcaagagtc 1740 tcgttcagct cttaaatagg gtttgctttc ttttagttac agtgcccatt ttgaaattgc 1800 ctatacagtc ttagtgacca tttaaaccgg acgaactagg tgtttaattt tcactcttca 1860 tgttcaatta gcagttcaaa ttaaagaaga tggttattgg agaacttttt tgaatggttt 1920 tgtattaaat tgctttgaaa tagatttcat ttcttgtgca cacagcccaa gatttcttca 1980 atgggtgtga gctagttgag ggttaacctt gtaggttgca gagtgtattt gtttgtttgt 2040 ttgtttttct cngtgatgag gtcagtgctc tgattttgaa ggaggatatt cactgaagct 2100 catagttata aacaaggaaa tcactgttaa gaatgggaat ttgtcctgtg ttctgggaat 2160 aacataaaga gagcaactga tttcagccca ggttttgcca ctaccctata attagtgcag 2220 tcttatgtta taaaagaaag aagttaacta tatttgggga caaaaaaata tttcaagagt 2280 tgataaagat tacctgtgca gtgcagagca ctttaatgca accagctttc aagaaaaagc 2340 cctatctagt acttgatgtt gatgttttta ttttgctgag caaaataaag ccaatgggag 2400 aaagactatt ttaccctttg cttttctcct taaacgtaat ccagatgact ttcctgttac 2460 taaacactga gcagcattac actacaatgc ttctttggtt tccaggaatt tttttcaaat 2520 ggggctgttt ctggaaaaat gaaaaattct attggacaat ggcaatatca acaatgagga 2580 aaattactga agaataagtt tccataagtc tcctacatag cagtgttatt tatgtacaga 2640 taagaaaacc atatgtcagc caaagcattt tatctcttct tctaactttt agtcacgagg 2700 caaaaggggt tataaaacct ttcattaatt caggaaggcc atcatttaga aggaacccca 2760 aaaaaaattg ccatattata aatgtgtgaa tcagggctgt gaaggacaaa acagggcagc 2820 acacatgcgt aacaagcgtt gcagaaacac cagagagtgc gtatcctgct cagaaccatt 2880 cacatttaat tcaattcttg gaaaaaatta aagctttttg cccacaattt gcaatctgtg 2940 ggttaatagt taaaagaatg ttcccaacca aaaaattctt accgtaatat tatatcttgg 3000 ccctacttat ttacaaaata atatgtttct gttatggtcc ttagtaataa ttgaagaggc 3060 ttagaaatac atctgcttgt ttattgagaa aacgatgcga ataattctgc ttttagagcc 3120 ttgttatttt atttcacaaa acaggcatat gtctaggagt gtaatatgtg gatggttgag 3180 tttgtaagaa caatcataaa aggacttgtt agtctccaga 3220 <210> 46 <211> 2961 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:399478.1:2000MAY01 <400> 46 ' tgatcagtta ttgtgacctt gactcactca tttctgatga actttctggg gcccgatcaa 60 gcatctgcca tcactggttg ttgacagggg gctgatcagt ctattatggc ctcagctaaa 120 gtgactcagc tttcctctat ggttcttgta tccttcagta ggctagcttg agcttgtttt 180 catggccatg acgtggttcc aagagagata agaagcacac aagacctttg taaggatcag 240 tcccaccgct ggccacaatg gttcatgctt ataacttcac ctctttagga ggctgacgtg 300 tgagggtcac ttgaaaccag gaatttcaga ccagctgggc aacaaaggga gacctcatct 360 ctgatatttc cagtgtcaga gggacacagc caacgtgggg tcccttctag gctgacagcc 420 gctctccagc cactgccgcg agcccgtctg ctcccgccct gcccgtgcac tctccgcagc 480 cgccctccgc caagccccag cgcccgctcc catcgccgat gaccgcgggg aggaggatgg 540 agatgctctg tgccggcagg gtccctgcgc tgctgctctg cctgggtttc catcttctac 600 aggcagtcct cagtacaact gtgattccat catgtatccc aggagagtcc agtgataact 660 gcacagcttt agttcagaca gaagacaatc cacgtgtggc tcaagtgtca ataacaaagt 720 gtagctctga catgaatggc tattgtttgc atggacagtg catctatctg gtggacatga 780 gtcaaaacta ctgcaggtgt gaagtgggtt atactggtgt ccgatgtgaa cacttctttt 840 taaccgtcca ccaaccttta agcaaagagt atgtggcttt gaccgtgatt cttattattt 900 tgtttcttat cacagtcgtc ggttccacat attatttctg cagatggtac agaaatcgaa 960 aaagtaaaga accaaagaag gaatatgaga gagttacctc aggggatcca gagttgccgc 1020 aagtctgaat ggcgccatca aacttatggg cagggataac agtgtgcctg gttaatatta 1080 atattccatt ttattaataa tatttatgtt gggtcaagtg ttaggtcaat aacactgtat 1140 tttaatgtac ttgaaaaatg tttttatttt tgttttattt ttgacagact atttgctaat 1200 gtataatgtg cagaaaatat ttaatatcaa aagaaaattg atatttttat.acaagtaatt 1260 tcctgagcta aatgcttcat tgaaagcttc aaagtttata tgcctggtgc acagtgctta 1320 gaagtaagca attcccaggt catagctcaa gaattgttag caaatgacag atttctgtaa 1380 gcctatatat atagtcaaat cgatttagta agtatgtttt ttatgttcct caaatcagtg 1440 ataattggtt tgactgtacc atggtttgat atgtagttgg caccatggta tcatatatta 1500 aaacaataat gcaattagaa tttgggagaa gcaaatatag gtcctgtgtt aaacactaca 1560 catttgaaac aagctaaccc tggggagtct atggtctctt cactcaggtc tcagctataa 1620 ttctgttata tgaggggcag tggacagttc cctatgccaa ctcacgactc ctacaggtac 1680 tagtcactca tctaccagat tctgcctatg taaaatgaat tgaaaaacaa ttttctgtaa 1740 tcttttattt aagtagtggg catttcatag cttcacaatg ttcctttttt gtatattaca 1800 acatttatgt gaggtaatta ttgctcaaca gacaattaga aaaaagtcca cacttgaagc 1860 ctaaatttgt gctttttaag aatattttta gactatttct ttttataggg gctttgctga 1920 attctaacat taaatcacag cccaaaattt gatggactaa ttattatttt aaaatatatg 1980 aagacaataa ttctacatgt tgtcttaaga tggaaataca gttatttcat cttttattca 2040 aggaagtttt aactttaata cagctcagta aatggcttct tctagaatgt aaagttatgt 2100 atttaaagtt gtatcttgac acaggaaatg ggaaaaaact taaaaattaa tatggtgtat 2160 ttttccaaat gaaaaatctc aattgaaagc ttttaaaatg tagaaactta aacacacctt 2220 cctgtggagg ctgagatgaa aactagggct cattttcctg acatttgttt attttttgga 2280 agagacaaag atttcttctg cactctgagc ccataggtct cagagagtta ataggagtat 2340 ttttgggcta ttgcataagg agccactgct gccaccactt ttggatttta tgggaggctc 2400 cttcatcgaa tgctaaacct ttgagtagag tctccctgga tcacatacca ggtcagggag 2460 gatctgttct tcctctacgt ttatcctggc atgtgctagg gtaaacgaag gcataataag 2520 ccatggctga cctctggagc accaggtgcc aggacttgtc tccatgtgta tccatgcatt 2580 atataccctg gtgcaatcac acgactgtca tctaaagtcc tggccctggc ccttactatt 2640 aggaaaataa acagacaaaa acaagtaaat atatatggtc atatacatat tgtatatata 2700 ttcatataca aacatgtatg tatacatgac cttaatggat catagaattg cagtcatttg 2760 gtgctctgct aaccatttat ataaaactta aaaacaagag aaaagaaaaa tcaattagat 2820 ctaaacagtt atttctgttt cctatttaat acagctgaag tcaaaatatg taagaacaca 2880 ttttaaatac tctacttaca gttggccctc tgtggttagt tccacatctg tggattcaac 2940 caaccaagga cggaaaatgc t 2961 <210> 47 <211> 2099 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:229648.2:2000MAY01 <400> 47 ttggtttcct taattagttc cctgtgccag cccatagtca gagccattaa ttggctctgg 60 ggaagatcca agttattttc tgagtaagat attaggcttc catatgatcc agagatgcaa 120 agaaatccct agagagtgta ggagttgtct aaatccatgt gtcagatgta gccaacgaat 180 tatgtcagaa gcagagagaa aaggcctgaa aagcagctct ctcccactcc tcaggccctt 240 gtctccaacc ttacatgagg ctttttgaac atctcctcct ggcccagctg gggtgagagc 300 aagtcctcga aggcactgcc tttgagcctt gctcagccca ttctgaacta tcccaactct 360 agaattgact gctttcgaat tgtgtgacct tgggaatgtt atctggcttc aaccacaatg 420 ccctaccccc agctcctctc ccaaatgatc ctagatacag ggctgcttcc ccccgaccct 480 accccacctc gggacacagg ctcatggcct catggcactt caccaccaga agtggtgctc 540 agagttccta tttccacatc taacccccta attcctggga aagtctgagg cctggtcccc 600 ccagtgcttt ccctggctgg cctctccaca ttttcatctg atggtggagt gagatcagga 660 aaaataggac aggagctttg ccttggggga gaagagagtt aagtgtggaa aggggtgagt 720 tataggaggt taagcagtcc aagattttct ctccctgtgt aggaggccat ttcctgatgt 780 gaggggtctg aaacccaatt atgatgggac agggttgggc attgacttcc catctcttct 840 ctctgttttt ctcccactat ctgtagccca aaactcttat ggaggacttt gatctttagt 900 ataggctatt ggtcagggcc ataggaacta accccgatcc tcactccacc aggatctacc 960 acatccccta cacacaaaca catgctgtgg ggagggagtt tttccctggg gtcaaattga 1020 gggatccctt aggatcaact tgtgctcctg tggactggtg tgtgcgtgtg tgtgtgtgtg 1080 tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tggggaaact tagctttcag agaatgtcta 1140 tgggctctca ttttctctct cacacaaaaa tactcgggac ttctccaagt ccctgaggag 1200 cctgaccact gaagctgatc atgagatgac tgtatgctga cacaccccct tcaggggcct 1260 ggccttgact tagggctgca ctgtatcctc agcaacggcc ttgcaggagc cccttttgga 1320 ctgctttccc tattcagccc agagttgggg tggtgggaga agaggggttg gagtgaatcc 1380 atctctattc aaattccagc tgggattact ctaggagtct tcctggcttg tatggggctc 1440 aaacttagct acattgttta ttggctccca aagtcgggat tgaagagtga aaagatgcag 1500 gcaatgaatc cttctgcaca ctcctcccca acctttccag cgcttttcta cttaggaggc 1560 cagtggaagg gaggagaggc catgccctag cccaccaggg gacaaggttc attgttcctt 1620 ccagggcttg gttcactctg cttttgattc agaagctctt tccctaccca gcaagactac 1680 actttcttgc cttctttcta ttttttcttt ttgtgcgtat aaatggtatg ttgtgatata 1740 ttctcagtgc ttgtgcccac cttggaactc tgttcttgct cttcattccg catgtgatac 1800 tctggtccaa gatcttggcc aggtgccttc tgctcaaata tcgtctcaga ggtgcttccc 1860 ttgaaaactc ggtgctgttt ccatagttac tctatttgat cactctaagt ttggttgtct 1920 tcatagcact tgtcaccctc tggaactatt ctattcattt atttacttgt ttaatgcttg 1980 gctcttttcc cctcctaacg taaactccat gattgccaac acctgtttac ttactacagt 2040 tccccctccc cccacattcc tgacactagt aagaaccaat aaaacacttg ttgacggaa 2099 <210> 48 <211> 1704 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:025643.2:2000MAY01 <400> 48 ggccagacat ggcggaagag gaggtggcca agttggagaa gcacttgatg cttctgcggc 60 aggagtatgt caagctgcag aagaagctgg cggagacaga gaagcgctgc gctctcttgg 120 ctgcgcaggc aaacaaggag agcagcagcg agtccttcat cagccgtctg ctggccatcg 180 tggcagacct ctacgagcag gagcagtaca gcgatctgaa gataaaggtt ggggacaggc 240 acatcagtgc tcacaagttt gtcctggcag cccgcagtga cagctgggag tctggctcaa 300 gcttgtgcct gtcccaccta aaagacgttg gacgctgtca gatgtggcaa ctcctgaggt 360 gacgatgaca aagtgttcgc tggaatctat acagatgagc tggagttcag agaggatgat 420 gtgttcctga ctgaactgat gaaactagca aatcggtttc agctacagct cctcagggag 480 agcatgtgag aagggtgttc atgtcctcta gttgaatgtc caggaacgtg gattccgcgt 540 tctaccagaa cgggcagcag gagcttgaat gccaacgcac acttgatgaa ctactggtgg 600 cagacaatta ttggcaacgt ccattggcga cagaccttga gcgaaggagg atttcaacgc 660 agcattgagc cgctccaagt ggttatacac aaatgatcaa atccaagacc agagtacccg 720 cgtacattaa agccatcaaa ggtggcgaga gaagacgtgg tcttcctgta atctgattga 780 aatggattcc cagctcccct ggaaagctga atgaagcgga tcataacgga gatctggcac 840 ttagaatctt agcccctctc acgacgactg gagaagtaaa ttgccaacca cgctggttag 900 tcaccaagct gatgtggaca tggtggacca agagtggctg gagccttgtt acaccaaggg 960 gattccaaag aaggagatct cttgtgctgc cactttccta cattaacgaa tggcggcctt 1020 gtgtcaacgc tgctacactg ggtgccccag gagacaccac ttgcaccttt gtgggccttt 1080 gtaccagttc cacaagaaac actcagctag atgtgatgcc tgagatggcc gcagattgca 1140 gaggcccttc tgcaggctgg gtgccaaccc ccaacatgca ggacagcaag gggaggactc 1200 ctgttacatg tgtgccatct atggccgcgg gatatgatat atgtgtctca gtcagctgct 1260 ccagtcgcaa acaactagat ttagaactca atagaccacg agggcaagca caggctactg 1320 tggcatggct agtgcagcat atcacaagtg tcttctgaac cagtctggga acccccttcg 1380 aagatgtccc cggtggtaaa ctgggacttc actttgagtg agaacacggt ttgcgagcca 1440 gaactccatc catgcgcggg cagtccacta catgactgca ccttgacacg gcgacaggta 1500 aagcacgtgc ctcccgaagg ggcgacgctg gggtcctgca ggcgccagga aatggcatgt 1560 aaatgccttc accccaaatt tagaaactga acggcatact atgaggataa ttatttggta 1620 cttaatttta tatacagtaa aagcctgggt tgtcattttt aaaaatcctg tgcttcaaac 1680 aattgagcag acatcaagtc cctg 1704 <210> 49 <211> 2276 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:233942.1:2000MAY01 <220>
<221> unsure <222> 1738, 1955, 1964, 1968-1969, 1976-1977 <223> a, t, c, g, or other <400> 49 agagaataac aagtctggga ctgacgtagg aaaaacagta gtctgtttaa gttgagagga 60 ggaggatgtg gacgagagaa gggaggagag ggaagaactg aaatgtctcc tcacccaggg 120 tggttattgg gcccaacttg ggatggggtt gagtacgaag gttaaaaaac atatactttg 180 gtattatatt ggtcattgta atagcagttg taaaatatgg ggggaaaagg gatcatttgc 240 tttcctttca tggtgttaat gtgtgcctga atctatagcc gctaaaatgt aaggctgtcc 300 acctgactta tttaaatatt atcagagaat agaaagtaat cactttttaa gtgtacctat 360 gtgctgcccc ttaaaacatt catggcatct ggcaaataga cccttgtagg ctggcctggc 420 atattcagat gttgccgcat catcacagag aaggtccaat gaagatgtaa ccattgctgc 480 tcatgtgtct tctctaagca acaaggggag cgggatgtac gagagaagtt gctaatgata 540 ctgtacaaag gatggattaa ataatgaagt caatttcatt gatagaaaat gcaaatttta 600 agattctcag tgtatgaggt ctcagcctcg ggagcattta ttttttactt tcctgctaaa 660 aatccactgg ggaggtataa aattcactcc aaagaagttt gcctgggcca aaagcctcca 720 ggttccttct gagaacaaaa tactaatgat tttttttttt ttttggctgc ttgggagaga 780 ctttcagcat tctttcacga tatcccagat atgtcccttc agcacacaca ctcaactttc 840 tcatctggtt cgtttcatcc tcccgaaaga acggtgctct cccactctta ctctatttca 900 aagagctact ctgtctcaac cacagcagcc ctgccaagaa aaggcaagat gaaaggctag 960 agcatgtgct accttgagat ttcaagaagt gtcctacctc agctgaagat ggagaaacgg 1020 ggagtggaga ggggatcagc ccagggtacc atgtgatgac taatatgcca ctcattaagg 1080 gcttttacct cggctgtcca catccagtca tgcatttggg gccaggcatg cctgcgaaat 1140 gattgacatt cctgtaggtg ccccatagag gtgtggcatt gagaaattat gtctggaaaa 1200 tacagccagt gtagtgacca gctgagttac catatagcct gatgattccc cttctgtaac 1260 agaaggtgac aacaactttg tgaactttct atatctttat ctgatgcccc aagtggcatc 1320 ttctttatgt acatgcctta gttgagaata tgagactgct ctaatctttg tgaatgcctt 1380 cacacttcag ctgaggatgt caccttctct gtcactcccc atcctgcaac ctctggcctt 1440 tgctctgtct accccagcaa ttttcatagt gttatccagg tactgtgcta aaaggtcagc 1500 tcttctgtaa aatgccatgc ttcgcagctt caaaaagcaa aattctgtat ttcatggagg 1560 gagggaaggg tcattctctt ctaagaaaaa tagactggag caggcgaaat gcatgcatgc 1620 atgtgtttag agttgcttct cagagagaca taagagatga tagcaactat tacaatatga 1680 ctgaatgact gagtgaatga gttgaaggcc tagctcgggc tgataaagct tttgcctnta 1740 gtagaaggtt tatgtcaaca ccttcaggag ggaagccctt atttctgggt tgaactcccc 1800 ttcccatgat attatgctag ccattgccat cacttagttc ctggcgaagg cagaaaaaga 1860 aaccaaaaaa tcagcattgt cattgacaaa actggatgct gaagataaag taaaaattgt 1920 cttttccctt gtccccacat ttttggggat taaanccccc taangggnna aaaaannttt 1980 ggacatagga aatacagtac tatttctgaa gttgatagcc gatcttttaa gaagaccctg 2040 tctttagaat gaaactagca ggcaaacacc taaataatcg aaaattacca aagttcaacc 2100 acgaaacaag aaaacctaaa gatttttact tcctattctt attcctttcc ttattactgt 2160 gacacccctt gcattgctca gttgcttgtg tgtcaaaata acttgtggac gtctggaaat 2220 tatttgaaaa tgtattgtga aaaatgtaat aaaatgatga tatttttata caaaaa 2276 <210> 50 <211> 4111 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:089158.1:2000MAY01 <220>
<221> unsure <222> 2410, 2431, 2438, 2440, 2470 <223> a, t, c, g, or other <400> 50 cactccagga gttccccatg gagttttcaa caagcagaga ataaaaataa atgtttgtga 60 ttgacaactt ttttccaaat gtttgaaact tcacatagaa aactgtaaag agatggccct 120 ccctcactgt atattaacat tttaagtaaa accctttgtc ccagtgttat acaagaaagt 180 tcaacaacaa aaggaaggaa aaaacaaagt gagaataagc ttcttggata ccatccctag 240 atgatgaagt gcagaaaact ggaaaaacct gacatcctgc atggagaccc aggaaataac 300 atggcatggc aaatcccagg gaagaaaact catgtgtaaa tcaaacagag ctcaaggaaa 360 agactgaaat ttcttctctt catgtttcaa aaagaattcc agaggtcaaa ggaacaggtg 420 caggtgcaaa tgtatataaa aataatgagc agcgctcatg acaaatcagg atagctacat 480 tcagtcatct ttcatgtatg tctaaactca ggccaagggg caataagtgt ccactgtgct 540 ttaaaaggtc tagaaataga aaaatcaacc cccaaatctt ttctaattcc acatggccat 600 ttgtcacgag atgactaaca atgtctgtgg ggtcaggttt aatacatttg cactgagctc 660 gtaccaggca gtccataaaa ctgttgtctt aaaatttctc cagtccccac atgtggctgt 720 tttagaggca tttccaaact taaaacccag cttctatagc tctccatacc tcttttacct 780 gcttagaaat gaatcccacc agacctccac gaatccaact ttgttaaatc atcccctatt 840 gctgatcaaa ctcactgctc cagcattcaa aaaacagaag gcataaaggt gaatacaaac 900 ataagaaagg agtttacatc gtggtcttgc agagctttcc atagtagtct cataaagtcc 960 tggtgaatcc cccagcccgc atatcttgtg cagagccaac ttgagtgtta tcaatcgcgt 1020 gtcaaacagt gataggagct tggtgtatgg gccgccgtcg ctctgggagg atggtggtgt 1080 aggaagtgaa cttgactctc ttcctctttg ggcccgaaga attcataggt tcatttttaa 1140 tttctttctc atagacatag ctcagagggt ctgagtagtt gactatgaaa agtcttctgg 1200 gaactgccat tcagaaggaa gttcctctcc tcgaactgca ggcccctgtc tatcatggtt 1260 gtgcactcct ctgatgggag tgtaatgtca acagggttct ccaaaaagtt ccacttcatt 1320 cccaagccag acccagtcgt gggaatgggg gatgttgccc tgctcactca cagcaaacct 1380 35!104 tttgtgtctg tatttccagg caaacgccac gcagttgatc aagaagacca gaatggccag 1440 acagaagacg cagagcaagg catacatgcc aatctccaag tccgttagcc cccttgaggt 1500 cactgtgagg tcactaggat tattgggggt ccggtgactt cccttgagtg gggaagcttg 1560 taaaggcatc tggaccacca cttttgagta acttattctt cccttccatg ggagactggg 1620 gggttgtgct ttcgttggta ctttcctctt tggcaacagg tgtgccacgg tggaaccatt 1680 cctggactgc tctctcctgg tttccttcgc gctctatgga attactgagg tggtctttat 1740 attcccgatt tatgccctca atatcattgc tgcctccttg gtgctcatca ctacttggtt 1800 cgaatttgac cttgacattt cctttaccca cggcaagaac actcttcctc ttggtcttct 1860 ggacaaggtt cacttatcat catttctaac ttaatcaaag gcccttgtcc ttcaccctct 1920 gcaaccacaa ttggccattg tggactcaag gtttgcctgg acagacacca ccatttcatc 1980 caatgatgag acagtaacag aataatcctt aggatcgtaa atgtctaaag gtgtcaccga 2040 accatcactg aacaaaatcc aagaacttac tattgcttcc tgctgtgggg actgaagaac 2100 atccagggca gcagctgtgg agacgatggc ccttttgtct gctcggtgtg gctgcaggga 2160 gagagacatg ccagctacga gctgcactcc cagctccacg atggtgactc ggtcatccag 2220 gacaatcacc gtcttctcag ccaggatgga gtcagacaac ggcgagagga cctgcaccgt 2280 ggttattccc ggctcccgac cagccagggt cctgccgtcc tgtaactgag cgattttcgg 2340 ctcctccacc ttcatgaact cggtcacaaa gttccagtga tgtcaaactg ccagtcgggg 2400 cccagcattn gtaggtcagc tagccctaag nttccagngn ttgaaaacct tccgggggcc 2460 caagcaaaan cttgggtgag gacacgcact gtggcgtgct ggtactgcag ggatgcagcc 2520 tcagtccctt cttctcctca tcgtcctcgt tccatttcgc tttcccgggt aggccttctg 2580 ttggcagcaa ccgggatcct ccagcccttg atctggctca gctcggtgtc tgagatctca 2640 atctgcaggg ggagcctggg tgcccagaca gtgacctcga actgggaggt gaagtgctgg 2700 tgggtgaagt tcacaatcgt gtccactttg ctcttgcatt tccttcccag ttcacagaaa 2760 atggaatcac agttgttgga aaccttaatg acatcttcat cgcgcagact tgcattgcca 2820 cagactcatg acacatcgac cacagaacca tcctcgctgg acccccacga ctttgacagg 2880 aactgaaaca ggcctttcca gtgagaatgg cggtgttcaa aacctcggtg tccatggcaa 2940 gagggacgat gcccacgaag gttgtctggc tgacgaagat ctcggagacg accagctcac 3000 tcatggagtc ctcaatcggg tactccacct gccaggtaat ctgctgggcc ccagccaggt 3060 cactgctatt atcaattcca aagtccactt gcaagatctc atagaaggat ccatttaccc 3120 tgctctgcgt gtccgggcga tggcccatgc aggtgagggt ggccgacgtc tgagtgctgc 3180 cattatcaat ttcctcctgg actgcccatt ggtcctcact gctgactctc actgccgtta 3240 tcttcacacc tgctgccgcc ttaattctaa gagtgaactg gtctgccaca gagctactgg 3300 tcagagagac caaaaaggtg gccgtgtccc cttcccggac tagattcaga ggtaccgaga 3360 tgaccacatt ctcgtccaag ctcaccaggg accacttcag atcatccttg gttggttaga 3420 ccaccacact cccaatcctc tctcgggctg gaaacgcttg ctgggggctc tccaggcccg 3480 agtggatatt gttctcccac ttgccttcct cctccagagg acactggcca gccttgtcag 3540 ctgggtagag cgtgaagaag agctccattc gtggtgcccc cgaacagggc tgggatttcc 3600 ttctttggtt tccagttcca gccttaagtt gaaccattcg gccaccagtt ccagttcaag 3660 ccaacacaca gcccctgggc cccttgcagc cgacagctgg ctgccacttc cctggcctca 3720 gggaaagcaa acatcttgac acagggtaga tcttccgtaa ggtcactgtc atcccagccc 3780 atgccagtga cataaaacaa ggtctgcact ttgggtctgt tggagtagat ggagctgtca 3840 aggatgtggg atttcaattt ccagttgaag ggaaatttgt ccatgtttcc aaaggctgta 3900 gatgtcaaca ggagctcctg ggggattatc ttctccactg aaaatgggcc atagctggca 3960 ttgataatag ggggtgtcct ggctcggtag atgaagaatg gctccacccg ggcctgcaga 4020 ctggagttcc ttgtgaggtc ttggttggct tctttaagga aaaaggactc ctctgcattg 4080 gagatgtgca agttcgtggg gaggtaagca g 4111 <210> 51 <211> 2353 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:101046.1:2000MAY01 <400> 51 gcagccagga agcacccaga actcttctgc cacagttgta gaattgtagg acccagtggg 60 caccaccttt gtctcctggg caagtccctt taccttccaa ggcctccttt ctcccaccct 120 gctccacttt tctcagcctc ctgaatgagg atggaggctt aatagacatg agaggatttt 180 gttttcagtt caatgacata gagttaagtg agctgtcagg gaagacgaga ggcatagctg 240 ctgtgagctc ctgagaccct gaaaatgctg gtttgcttca caggtgccat ctagaactta 300 acaggcactt tcggaaaaag ttggctgagg aggaacctgc tggggtatta gaagctgcca 360 ccagcgggtt ggtgattgat gttctttggg gccacggtga ggcatctttt tcattaaagt 420 ggggctttgt gtcctacaag tgctttgagt tcagagaaaa gatgaaccaa aaatgaagaa 480 aggaagtggc tcttgcttcc ccagcaaaga gttacttgcc ttctgaaaca caggccttgt 540 tgccacatag gaccagcccc tccagagtct cactcctcaa gttctgtgag acgctgcaga 600 ggacctggcc atggccttga tcttatctag accttgggaa cacccctcaa ccatcctcac 660 ctcacttcag cagaatggct gtctaggact ttaaaaatga atgttcacct ttatcgtgcc 720 ttacatcttg gaaaaagatg tttcataagt ttactcttct cagggtgaaa taggcctttt 780 tatttgtcct tcgcctgtct ttttcagatt tcaagggaga ttccttaatt cttacattcc 840 aggagtcagt gagacaatct atgcttcccc tccctgaccc tttttgtgtt tctcggtgtt 900 gatatttcac atgcttggtc cttctctttg aactttttag tgcttctggg tcatcatcct 960 gatctctctg tggcaatgcc ttcctccagc tcccacctct aaatcatctt ggcttcccac 1020 tgcctggcct tttctaaaag aaccccaatc ttcattgcct ttaaaacagc cagatttgag 1080 tcaatttcat attggtggcc agactgttta aacacaaatt ctctagctat ttacagggct 1140 cagagctgag gaggaagaaa ctcaagtccc caaataatga ctaatcacaa ttcattctca 1200 ccagcaagag ccatgaaatt ctaaggagct ggaatttggg atggcttcaa gtggccagta 1260 caattgaagc gtctggcaga caggcaaaga agcctacctt ctcccctccc cacggtggca 1320 tcaatggaat cactttcttg ggtccctcac ttaatatgaa tcatattcac ctggggcaac 1380 caacgcctga cagagttgta gtgcagaagg cacctctttg aagtgaaaac caggagatct 1440 tttatcactt ccccagccct gcaggctcag tcacatgtca aatagataat gaataaatgc 1500 atcgccaatg cactctattc atttattttt gacaagtgag ttggtgacag tgcccccttg 1560 catgctaata aaatatacag cagccacact tgtaaagtct ttgaaatacg aggcttcatg 1620 caagtactcc actattaaat ctttgcagga aaatggggta accagactgc tgggactctt 1680 gcaaaatgat tacgtttgaa gattagtgcc attctcctct acacaggcta tggtttcaga 1740 cagcaccatg gctttgataa agtggctccc agctcatagg aacttgataa ttaatgtcct 1800 ctgtgttgca tagagatcag gcatcaaaaa ctcggtggtg ctgagacgcc aacagaacag 1860 gattcttctg gtgtctggac cactgagggc tggttgtcaa ggagttatct tctcttggtc 1920 gcacctagtc cacgtgaggg agaggaaggc ttcacattgt ctttacttgg gcccttgaga 1980 ttctaggctt tagacaatct gaagctgtta gacctatcag ccaggcttct ctctgaccaa 2040 ggacaaccca aggggctcct tagaccagcc tcacctgtct ggatcaccat tctcctccag 2100 cttcaaaagt ccatccttcc tgcaaatctc atcaagactc gcggctctta aagataaccc 2160 tctccttcct gcagcacttc tatgcttgaa ggggaagggg ctggcacaca tcttctctgt 2220 gtggcctcct cctcctggcc acacggcctt tttcctggcc cctttcctta cactgttgac 2280 atgacaaggg atctgaaaag ggaataagtc caggttaaag cctcaaatgg cacagatcaa 2340 aacccactct ttc 2353 <210> 52 <211> 3301 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:368676.2:2000MAY01 <220>
<221> unsure <222> 2902 <223> a, t, c, g, or other <400> 52 ccagggcgga cgcacgtgcg ccgggcttgc ggcgccctgg ggcccaccga ttccccaacc 60 gtcgttttcc ccaccgaggc cgaagcgtcc cggagtcatg gcccggccta aactgcgggg 120 tctctatcgc actgcctagg ggttctgctg cggggttgcg gggcgcctgc cgcgcggggc 180 agaagctttt gagattgctc tgccacgaga aagcaacatt acagttctca taaagctggg 240 gaccccagac tctagctggc aaaaccctgt taaccgggtc atttctaaaa gacatataac 300 catgttgtcc atcaagtctg cgagaaagaa tagtctttac ctttagctgc cagaagtcct 360 tgagagtcac tttgtcatag agatcccaga aaaaatattg aactgtatgt caggcccatg 420 tcccttttgg gggaggttca gcttcagccc tcgacatcgt tgttgcctac cctcaacaga 480 actttcatct gggatgtcaa agctcataag agcatcggtt tagagctgca gttttccatc 540 cctcgcatga ggcagatcgg tccggtgaag agctgcccag acggagtcac taactccatc 600 agcggccgaa tcgctgctac cgtggtcagg atcggaacct tctgcagcaa tggcactgtg 660 tcccggatcc aagatgcaag aaggagtgaa aatggcctta cacctcccat gggttccacc 720 ccagaaaatg tctccggctt cagcattgaa acccgctcat ctataaaacg tctgtgcatc 780 atcgagtctg tgtttgaggg tgaaggctca gcaaccctga atgtctgcca actacccacg 840 aaggctcccc tgaggatgag ctcatgacgt ggaagtttgc cgttcctgca cacctgcggg 900 ccagcgtctc cttcgtcaac ttcaccctct ccaacttaga gaggaaggag gagcgggttg 960 aatactacat cccagggctc caccacccaa ccccgaggtg ttcaagctgg aggacaagca 1020 gcctgggaac atggcgggga atttcaacct tctctctggc aaagctgtga ccaagatgcc 1080 ccaaagtcca gggatcctgc cggctgcagt tccaagtttt ggtccaacat ccacaaaatg 1140 cacagcaata aaatctacgt ggttgacttg agtcatgagc gagccatgtc actcagcatc 1200 gagccatggc ccgtcaaaca gagccgcaag tttgtccctg gctgtttcgt gtgtctagaa 1260 tctcggacct gcagtagcaa cctcaccctg acatctggct ccaaacacaa aatctccttc 1320 ctttgtgatg atctgacacg cctgtggatg aatgtggaaa aaaccataag ctgcacagac 1380 caccggtact gccaaaggaa atcctagctc actccagggt gcccgagtga catcctccac 1440 ctgcctgtgg agctgcatga cttctccctg gaagctgctg gatgcccagg gacaggcttc 1500 agcctggtgg ctggtgccag cccagaagct gcagcagcat acacacgaga agccctgcaa 1560 caccagcttc agctacctcg tggccagtgc catacccagc caggacctgt acttcgcctg 1620 cttctgcccg ggaggctcta tcaaagcaga tccaggtgaa gcaggaacat ctcgggtgac 1680 ccctcgcacc ctttgccccc agcttccata caagaggcct tccaggcagg gttgtgacgg 1740 gcgtccttta taccttattt caaaggagga aggccgtttt cacggtgacc cctgacacaa 1800 aaagcaaggg tctacctgag gacccccaac tgggaccggg gcctgccatc cctcacctct 1860 gtgtcctgga acatcagcgt gcccagagac caggtggcct gcctgacttt ctttaaggag 1920 cggagcggcg tggtctgcca gacagggcgc gcattcatga tcatccagga gcagcggacc 1980 cgggctgagg agatcttcag cctggacgag gatgtgctcc ccaagccaag cttccaccat 2040 cacagcttct gggtcaacat ctctaactgc agccccacga gcggcaagca gctagacctg 2100 ctcttctcgg tgacacttac cccaaggact gtggacttga ctgtcatcct catcgcagcg 2160 gtgggaggtg gagtcttact gctgtctgcc ctcgggctca ttcatttgct gtgtgaaaaa 2220 gaagaaaaag aagacaaaca agggccccgc tgtgggtatc tacaatggca acatcaatac 2280 tgagatgccg aggcagccaa aaaagtttca gaaagggcga aaggacaatg actcccatgt 2340 gtatgcagtc atcgaggaca ccacatggta taatgggcat ctgctacagg attccatgcg 2400 gctccttcct gcagaccaga ggtggacacc tacacggccg ttccagggca accatggggg 2460 tctgtcctcc cgtccccacc caccatatgc tccagggccc caacatgcaa aggttggcca 2520 catgaggagc cacctcctcg ctcccctcct gagtctgaga gtgaaccgta caccttctcc 2580 catcccaaca atggggatgt aagcaagcaa ggacacagac attcccttac tgaacactca 2640 ggagcccatg gagccagcag aataacttga tccattccag acgctttgct ggagtttcat 2700 aaagcagggc gctgagacac ccgtccgtgt tcctaaccag aaatcccaaa gaagaggaat 2760 tatacagaag gaacagcagg aggttttcct gtgacaccgc caacttcaca ttgctcagtg 2820 gactcattct aagggcaaga cattgaaaat gatgaattcc aatctggata cagtcatgac 2880 agctcatgtg ctcctcaaac tntaggcatg tgcaggttta gccaagccat gtaaatgaga 2940 ggagagaggc ctgagtcacc tagcataggg ttgcagcaag ccctggattc agagtgttaa 3000 acagaggctt gccctcttca ggacaacagt tccaagggca aggagcctac ctgaggtccc 3060 tagtctcact ggggtcccca ggatgaaaac gacaatgtgc ctttttatta ttatttattt 3120 ggtggtcctg tgttatttgg aggagatctg agtgtataac cacccagctc cggtcaccgg 3180 acttagtaat aactcatact aactggtttg gacgcatggg ttgtgacatt catactgacc 3240 gctagataaa cgtgtgcctg tcccccaggt ggtgggaata atttacaatc tgtccaccca 3300 g 3301 <210> 53 <211> 1834 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:238713.1:2000MAY01 <400> 53 agaaaccatt atatcccctt ggtaggcata aaaggggctg ctttgcccaa actgcctatg 60 aatttgcttc ctaaagcatg gggtgtgcct caggacctta ttaaaaagta cataaaactt 120 gaagaggatg gtggttgtgt tattggaggt gacagaagtt tgcaagataa atacttactt 180 aggcttgttg ctgctatgga agaagtcttt atggacaaac atggtatcca tcctagtttg 240 gttgctgatg tccatcagta tttctacaga aggactggag tgataggagt tcagcctgag 300 gaagtcacag cagctgctaa aaaaagcagt aatggataat cgccttcaca aatgtttgct 360 ctgtggtgcc ctttctgaac ttcatgttcc tccagagtgg ttggctcctg gagggaaatt 420 gtataacctg gcaaaaagta ctcatggaca gctgaggact gacaaaaatt acagctttcc 480 cttgaacaat ttggtttgct catatgattc agtgaaagat gttctggtac cagactatgg 540 aatgagtaaa ctaacagctt gtaattggtg ccatggcaca tctgtgcgaa aggtcagagg 600 agatgggtct attgtgtatt tggatggaga cagaactaat tctaggtcca ctggtggcaa 660 atgtggttgt ggattcaaac acttttggga tggtaaggag tatgacaatc taccagaagc 720 tttccctatt acttttagaa tggggtggaa gagtggtcta gagttaacag ttatattggt 780 tcctagtatg taagtgattc atctttgaat agtaatgttt acgatgttgc atatgaaact 840 tgttacctag catctttgcc aggtgaattt gggagtgaaa tcctagttca gaaagttgtc 900 ctacactata ttgcatcagt ctgcctcatt gtatcccgaa tgattatact cctgtaaata 960 tagatggtgc tcacgcccaa agagttggag atgttcaagg acaagaatca gagtctcagc 1020 tcccaactaa aattattctt actggacaga aaacaaaaac ttgtgcacaa ggaggagtta 1080 aacatgagta aaactgaaag aactattcaa cagaatatta cggaaccagg cttctgtaat 1140 gcagaaacgg aaaacagaga agttaaaaca agaacaaaaa gggcaaccca ggactgtttc 1200 tcccagtacc attcgtgatg gtccatcctc tgcacctgct acacctacca aggctcccta 1260 ttcaccgaca acttctaagg agaagaagat ccgaatcaca actaatgatg gacgacagtc 1320 catggttacc cttaagtctt caacaaactt ttttgaactt caggaaagta tagccagaga 1380 attcaacatt cctccatatt tacagtgtat tcgatacggg tttcctccta aagagttaat 1440 gccaccacag gcaggaatgg aaaaggaacc agttccttta cagcatggcg acagaattac 1500 aatagaaatt ctaaaaagta aagctgaagg tggtcagtct gctgcagcac actcagccca 1560 cactgtgaaa caagaagata ttgctgttac tggtaaactg tcatctaagg aacttcagga 1620 gcaagctgaa aaagaaatgt actccttgtg ccttttagca acattaatgg gagaagatgt 1680 atggtcttat gcaaagggac ttcctcacat gtttcagcag ggtggtgtat tctacagtat 1740 tatgaagaaa accatgggta tggctgatgg caagcattgt acttttccac atctgcctgg 1800 caaaaccttt gtctataatg cttctgaaga taga 1834 <210> 54 <211> 755 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:720928.1:2000MAY01 <400> 54 caaaccattg taaatcatga gcatgcagca tatggccttg gattcaaaat tcttgatgtc 60 ccatttcaac agaaaacatg ctgtcggcaa gtggattaca cagaaggtaa tattgccgta 120 ttgggagggc ttctggtaat actaaaaaaa tggagccata cttatgttta atagattaga 180 agaaagtaca tgtaaaacta caatgttgac acacatgaga ggatgctaaa cttttgcttc 240 atttgttttc tactccgagt gtacctgttt gttcatgaac attcacccac atgcatataa 300 tcacgggcac acaaacattc acccatatgc atataatcac gggcacacaa acatataccc 360 atatgcatat actcatgggc acacaaacat tcacccgtat gcatatactc atgggcacac 420 aaacattcac ccatatgcat atgctcatgg gcacacaaat attcacctat atgcataaaa 480 tcatgggcac acaaacattc acccatatgc atatgatcac gggcacacag acttatggga 540 gcacagggtt atgggcacat tcactccaac acaaacacac agatgtccca cccattttcc 600 taagagtctg acattaaggg attgcaacat tgtacagaag ccaatcattt gcaggtcact 660 ttgtccccag gaaagaaata tcttttattt ttctaaatcc tggtttccaa aagtattctt 720 gatgtgtgca aataaatata aagtgcattt ccata 755 <210> 55 <211> 2522 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:221874.1:2000MAY01 <400> 55 cggcggagat gcctcgttgg ggctgggaaa ctcctgcaaa actcgagacc aggaagccag 60 cccgcacccc aacccccacc aaagccacct actcttcttc tgtgggaggc cagtccacat 120 ccgctctcac ccgatgagag atattcagct ggatccaaag tgactgatga agggaaggaa 180 atcatgtcaa gcgaagcctt tgaaaaagct gccctgagac ggtgtcccgc cgaaagaatg 240 ttggctcaat taagaaacat cagggagata aattcaaccc agtgtgtcta aaaatgacta 300 ccaaaacgga gtttgttttg tgcggttggg taccatgtcg ctgtctacgg agggggaaga 360 ggagactgtc actactcttg attattctca ttgcagcttt agaacaagtt ccggaaagag 420 atttttactt ttgaaaaaac tcttggagga actctattta gatgctaatc agattgaaga 480 gcttccaaag caacttttta actgtcagtc tttacacaaa ctgagtttgc cagacaatga 540 tttaacaacg ttaccagcat ccattgcaaa ccttattaat ctcaggggaa ctggatgtca 600 gcaagaatgg aatacaggag tttccagaaa actatcaaaa attgtaaagt gtttgacaat 660 tgtggaggcc agtgtaaacc ctatttccaa gctccctgat ggattttctc agctgttaaa 720 cctaacccag ttgtatctga atgatgcttt tcttgagttc ttgccagcaa attttggcag 780 attaactaaa ctccaaatat tagagcttag agaaaaccag ttaaaaatgt tgcctaaaac 840 tatgaataga ctgacccagc tggaaagatt ggatttggga agtaacgaat tcacaggaag 900 cgccctgaaa gtacgttgag caactaactc gattgactga gataattgga gagtatgcta 960 atagactgac ttttattcca gggtttattg gtagtttgaa acagctcaca tatttggatg 1020 tttctaaaaa taatattgaa atggttgaag aaggaatttc gacatgtgaa aaccttcaag 1080 acctcctagt atcaagcaat tcacttcagc agcttcgctg agactattgg ttcgttgaag 1140 aatataacaa cgcttaaaat agatgaaaac cagttaatgt atctgccaga ctctatagga 1200 gggttaatat cagtagaaga actggattgt agtttcaatg aagttgaagc tttgccttca 1260 tctattgggc agcttactaa cttaagaact tttgctgctg atcataatta cttacagcag 1320 ttgcccccag agattggaag ctggaaaaaa aaaaactggg ctgtttctcc attccaatga 1380 acttgagaca cttccagagg aaatgggtga aaagccaaaa ttaaaagtca ttaatttaag 1440 tgataataga ttaaagaatt taccccttag ctttacaaag ctacagccat tgacagctaa 1500 gtggctctca gaaaatcaat cccaacccct gatacctctt ccaaaaggaa ctgattcaga 1560 gaccccgaaa atggggctta ccaaatacaa gttccctcaa cagccaagga ctgaggatgt 1620 taatttttaa tatcagataa tgaaagtttt aacccttcat tgtgggagga acagaggaaa 1680 cagcgggctc aagttgcatt tgaatgtgat gaagacaaag atgaaaggga ggcacctccc 1740 agggagggaa atttaaaaag atatccaaca ccatacccag atgagcttaa gaattatggt 1800 caaaactgtt caaaccattg tacatagatt aaaagatgaa gagaccaatg aagactcagg 1860 aagagatttg aaaccacatg aagatcaaca agatataaat aaagatgtgg gtgtgaagac 1920 ctcagaaagt actactacag taaaaagcaa agttgatgaa agagaaaaat atatgatagg 1980 aaactctgta cagaagatca gtgaacctga agctgagatt agtcctggga gtttaccagt 2040 gactgcaaat atgaaagcct ctgagaactt gaagcatatt gttaaccaat gatgatgttt 2100 ttgaggaatc tgaagaactt tcttctgatg aagagatgac aatggcggag atgcgaccac 2160 cattaattga aacctctatt aaccagccaa aagtcgtagc acttagtaat aacaaaaaag 2220 atgatacaaa ggaaacagat tctttatcag atgaagttac acacaatagc aatcagaata 2280 acagcaattg ttcttctcca tctcggatgt ctgattcagt ttctcttaaa tactgatagt 2340 agtcaagaca cctcactctg ctctccagtg aaacaaaact cgtattgatg ttaattccaa 2400 aatccggcaa ggagatgaaa attttaacag ccttttacaa aatggagata ttttaaacag 2460 ttcaacagag gaaaagttca aagctcatga taaaaaagat tttaacttac ctgaatatga 2520 tt 2522 <210> 56 <211> 2634 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1143545.3:2000MAY01 <220>
<221> unsure <222> 1800 <223> a, t, c, g, or other <400> 56 agcggagtgc caggctactc ctcccgcagt gtgggtggtt ccgaggctgg ctaccctgcg 60 gcggcgcggc tcgcagtcct tctcagcatg gaccgcactt gtgaggagag gcccgctgag 120 gatgggagct gcgaggaggt acccagactc catggaagcc ccaacccgga tccgggacac 180 tccggaagac atcgtgctgg aagctccggc tagtgggctg gcgttccatc cggcccgtgg 240 accttactgg ctgcagggga cgtggacggg gacgtgttcg tcttttccta c'tcttgccaa 300 gagggagaaa ccaaggagct ctggtcatca ggtcaccatc tcaaggcctt ccgagctgtg 360 ggctttctct gaagatgggc agaaactcat tactgtctcc aaggacaaag ccatccatgt 420 tctagatgtg ggagcagggc caactggaaa gacgtgtttt ccaaggctca tggtgccccc 480 atcaatagtc ttctgctggt ggatgagaat gttctggcca ctggggatga ccccaggtgg 540 tatccggtct ctgggaccag cggaaggagg gccccttaat ggatatgagg caacatgaag 600 agtacatcgc agacatggct ctggatccag ccaaaaagct gctgctgaca gccagcgggg 660 gaagggctgc acttgggcat cttcaacatt aaagaggcgt cggtttgagc tgctctcaga 720 acctcagtct gggtgacctg acctctgtca ctctcatgaa atggggggaa gaaggtaagc 780 ctgtggctcc agtgaaggta ccatctacct cttcaattgg aatggctttg gggccacaag 840 tgaccgcttt gcccttgaga gctgaatcta tccgactgca tggttccagt caccgagagt 900 ctgctgtgta ctggctccac tgatggagtc atcagggctc gtgaacatcc taccgaacca 960 gagtggtggg cagtgtgggc cagcacacct ggggagcctg tggaggagct ggccctctcc 1020 cactgtggcc gcttcctggc cagtagtggc catgaccagc gcctcaagtt ttgggacatg 1080 gcccagctgc gagcctgtgg tggtggatga ctaccgtcgg cgcaaaaaaa agggaggacc 1140 actgcgggct ctgagcagca agacttgggg gccccgatta cttctttcgc aagacttgag 1200 ggacgaggga gaagactcca tggctcagcg aagaaaagga ggagactggg gattaccggg 1260 gctctgaggg aatgaattga atcttgagac gggtcctcac cagccccagc cagaccacag 1320 gaggttgggc cccagactca ctgagtgcct gcagcagccg tacagacaca gcatccttgg 1380 ccacctcatg cccatcccgg ccatctaggg tcagcacaac ccagatgagg ccgctgaagg 1440 gcaccgggat ggccaggaat caccaccgtg gtaccagaag cggtgccagc cagcaggtcc 1500 tatgcccaaa cacttggtga ggaaacccca gggttggccc agtttcattc cgttggcaca 1560 gcaatctgca gggtagccct gagccctctt ggaaccctaa cgttgtctcc ttggccacaa 1620 gccacactgg gctggccgtc tggctgtggg gaccgcaagg aagggaccca ccaaagctgc 1680 tcggcagaag tctgctgcat tcaggtctgg cttgaggcca ctccacagcc acctgctctc 1740 cacagaggtt gtgactgccc tgtaaaggaa aaaatgcaaa gacaagggca ggtctaaaan 1800 ccctgggccc aagcctccag ggtggtgagc cctttggaaa gctacacagt cctgttaaat 1860 ttgtagcctg tgccatttcc tggtagtgtg atccatgggt aaagaaaaga caatgagagc 1920 cttcagccta cattatgttg caaaggtgag tagtaacagc aacgtgcgta cgcgttaaca 1980 gagtcttgcc tgtcggagat agtagctggt ttattgccag gctcttgtgc tgcctcagta 2040 agccatccat aatggcctaa tcctttactg gggaaaactt gcgtgtaagt ccagtcagtg 2100 tgctatacgt acacgtagca cccacttagt gttaccttaa cttgtcataa acagtctgag 2160 gaaacagatt cctatagtag taaaaaggct cagtttggat tccccttgag caaagtcaat 2220 ttctctaaca gtttctctca ttagcttgag ggtccctgtg ccctattttg cggtgtgggg 2280 gtgggggaag gttgagaatt aagtccagga ggtaatgctc gggaagtgtc acaaatttag 2340 gtaagcggtg gtggtagcac cattggaagt tttaaaaatc tgaggtgcaa atagtaaaag 2400 gttgcaaatt ctggcatgtt tgactctaag atcttgtaac tttaacagct atgctcagta 2460 taaagtgccg ggcagaacgc gtttggcccc aaccagcacc cccgccccag cctaccttcc 2520 accagggcct ttttggccat ggcagcggcc cggtgcgagc tgaatttgag cagagcgatc 2580 tgcccgggcg ccggtccggg gctgggcagc agccgcgcct cctgcaagcc ggga 2634 <210> 57 <211> 2196 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1143605.1:2000MAY01 <400> 57 gcataatgat caaatcaagg taatgttaaa tgcttgaggc gatgtatatc tccttatttt 60 tctaactgga cttaaattct aaagagacta tatataagtt aaaaatgaag aataaataag 120 agctcaatta aacgggaatt ttaaaagttc caataaattt gggataaaat gtaatgtaag 180 gtgtttcata tggagagcca tccctgcctt ttgatcactg tttccagaaa agcacagact 240 tgtgcacctc cctctgtgct ttcttatgtt ttgacagttg aacataccaa aacaggtgat 300 gagcaaactt gcaagcagtt tttactgata gtttttacat agcataatga agtataatgt 360 tatcaaccaa gaactgtaaa aaaaaaacac tgtgaggctt atgcctcttc cagacttgct 420 tttttgaact tttccataca ttttttgttt tagacctatt ccatctgggc tagcagttgt 480 aaaaacaaag cagagtgcaa tgaactccat ccgtctgttt ctgtggtaca gattttagcc 540 ttcatcctaa taagaaacat ccctggatat gcccgttcag tttacagttc attttttgct 600 tggtttggaa aaatttcatt agagctattt atttgccagt atcacatatg gctggcagcg 660 gacacaaggg gtatcttggt actgatacct gggaaaccct atgctcaaca tcattgtcag 720 cactttcata tttgtttgtg tggccacatg aaatttctca gatcactaat gatcttgcac 780 agattattat tcgctaaaga taactcatct ctcttgaaaa ggttggcatg tatagctgca 840 tttttttttt gtggactcct catcttatca tccattcaag ataaatcaaa acattaggtt 900 ccaaaaattc taaaaaacct aaactttttc caggctacct ttggtgtggc tccaaaaaaa 960 gaaaagcatc tatctggaga tataaatgtg tatgtaaata taaacgtttg tggcaagagg 1020 acagttctgt gacatctgtt gaacatatgt ggttgtaaat atgtgtaaat gtacatatcc 1080 caatatgaaa tactaagaca aacaaacaaa caaaaaacca gaatgcattg tataggattg 1140 catgtgaagt cttttctact gaatctatat ttccatttgt aagtgatttt aagttaacat 1200 atgaaggcag ggaaatgatt acctttccag taaaaagtat aggtaatttt aattaactta 1260 gtgacaccac caagtgtttt tgatataact aaaatttgtg gtaataaggc ttgtcttgca 1320 cctgtattca ttgtgggact tcctctttca ttggaaaatt tttttactca agaatgacgg 1380 cagtattgtt ttcttatatg tgcaatgaag tggaatgata aacagtatgc ctttaattta 1440 tatgtgttct tgttctgatg ttgtttcctg aaatgatttt tcttcctaac tgtggttttc 1500 gggtatgcaa gcctttaatc ttttgtacca ctttgtctca cagaatagtt ctgaggctcc 1560 atgacagggt tttgtcattg ttgatgttta ttgttgcttc gttttataaa aaagccaaaa 1620 ttttttttcc aatccaaacg ttcacctgtt tcctttcctc aagctatacc agttgtaata 1680 ccagttaccc tgtgggatcc atttaatatg ttatccccac taaataaatt tccatatatt 1740 atttcccaat atttgggaaa gcctctttat agcccatttg gggtatttcc tattacccac 1800 ctcctatttt aaatatttat cagtctaaac ttgtgcagtg tagtaaacat gcaagttgtt 1860 acgattgagc tgtattaccc ctaagtagaa tttctaagta aacctggtga atttggacca 1920 tagatgtttt tgctttttgt ttgatttttt tttacaagct aactgttaga ggtatacatt 1980 tatttatctg ttgtacagat atgattatga ttttaatgtt tgaaagattg cacttgtttg 2040 cttttactat atgtggggta aaatatattt tctgttcaca gtatatgaaa atatggagta 2100 atttaaacag taaataaaca ttctgtggat gcttattttt gtattggcaa agtatcaatt 2160 aaactatatg tgttcttttt caaaaaaaaa aaaaaa 2196 <210> 58 <211> 2250 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:474069.7:2000MAY01 <220>
<221> unsure <222> 209, 1246, 1435 <223> a, t, c, g, or other <400> 58 cccgcccgcc ggagactccc gcggcgggac ccgtcaaagc cccggggatg ccatggatcg 60 tcctcgttgg cggcttctgg acactgagcc actagagggc atcggtcccg gtaaggccgg 120 acggcaggct ccgggatacc gccacgctct ctatggcgcc cagaaagggg cggggtggcg 180 accgcagtcg ctttggctga ggctctgcng ggaagggaag gggggctttt acgtcatcaa 240 tctgcgccaa ctgactccca agtccctggc ttggagtggg aagtgaggtg tgggaagtag 300 gtcgctttct gatgaattca gtggcagtga attgagaccg gagggaatct ggcccctaga 360 ggctggtact tgggcccgaa acccccatct ccggcggaga gaccgtccga ggtaattgtc 420 tgccacgagt ggacattctg aaaacaggag attttagttc ctaaaaaatg ggaagaacct 480 acattgtaga agagactgtt ggccagtatc tttcaaacat aaatctccaa ggaaagggct 540 tttgtctctg gccttttaat aggcacagtg ttccgtcaca aaaggattat gtgatttctt 600 gccactagaa cggccaccca aagagggagc aaagtgagaa cctcaaacat cccaaaagct 660 aagtttggat aacttggatg aagaatgggc cacagaacat gcctgccagg tatccagaat 720 gctaccaggg ggacttttag ttcttgggag tatttattat tactacttta gaactggcaa 780 atgattttca aaatgccctg cgtagactaa tgtttgctgt ggaaaagtct ataaatagaa 840 agagattgtg gaatttcaca gaggaggaag tctcagaacg agtgacactt cacatttgtg 900 cttctacaaa aaaaatattt tgtcgaactt atgatatcca tgatccaaag agttcagcaa 960 gaccagcagg attggaagta tcaaagtgga ttatcatcct catggctttc tttagagtgt 1020 acagttcaca ttaatattca catcccactt tctgctactt ctgtcagcta tactctggag 1080 aaaaatacaa agaatggact tacacgctgg gccaaggaaa tagaaaatgg tgtttcattt 1140 cgcattaatg gacaagttaa agatgaaaga ttgtgaccta ttagaaggac agaaaaaaat 1200 cttctagagg aaatactcaa gcaactagtc attgttttgc atgtcnacga gtgctaacgc 1260 agttgcgtcc tgaattcaga ccacatgatc cacagccaca gtccacgata tcgtagcggt 1320 tctgtaaacc ttaacgggtg ctgtgaacat cgcagagctt taatatccac agcagtaaac 1380 ccaaagctta aagatgctgt gcaggcacgt aaacgaggga tatacttgaa cacangcttg 1440 ctgatcgttg tgaaactgct atttgacgga tctgcttttg caatgaaatt cccagaaaaa 1500 aaaagttatg agtataaaat tctgaaaaag agttccaccg tcctcccttt atccgagtct 1560 ttgttcccct tcctggatcc acctgtaatg ttgtgtgatt ataaatttga cgatgagtca 1620 gctgaagaaa tcagggacca ttttatggag atgttggatc acacaattca aatagaagat 1680 ttgggaaatt gcagaggaaa caaacacagc ttgtattgag tcctcctatg aatagtcaag 1740 cttcattgga caacacagat gatgaacaac ccaaaacaac caattaaaac tacaatgtta 1800 ttgaaaattc agcaaaacat aggtgtgatt gcagcattta cagttgcagt ccttgcgtgc 1860 gggtatctcc tttcattact tcagtgatta gggtgaggca caaagagttt cctgtgatca 1920 tccagagaac attgacagac aattatgaat aataaagatg ttaacaatcc atctgtattt 1980 aaaacaccta gccgccagat ctgctgccat gatgcctatt tggtgtgttt ctgattaaaa 2040 tgaaatcacc agctgccttg tttagcctgc tttacattgt aggtggcccg catttccaga 2100 aataacgtta tgcatctaag atggaagctg catgtaacca atcattatta tctattttta 2160 aaagcttcca aatgatggga tatgatcata gattttagtc ttactaatct gaatcacata 2220 ttaatccagg acatttaaaa ctttaacaga 2250 <210> 59 <211> 2963 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:245193.3:2000MAY01 <400> 59 gtgaggctgg cggtggcgac aaccgaggag gaggggcggg acgccgtgga gcacggcgac 60 cggctgagcg tcatggaggg ctcaggggag cagccgggcc cacaaccaca gcatcccgga 120 gaccaccgca tccgcgacgg cgacttcgtg gtgctgaaac gtgaagatgt gtttaaagca 180 gtacaagtcc agcggagaaa aaaagtaact ttcgaaaaac agtggttcta cctggataac 240 gtcattggcc atagttatgg aactgcattt gaagtgacca gtggaggaag tctacagccc 300 aagaagaaga gggaagagcc tactgcagag actaaagaag cgggcactga taatcgaaat 360 atagttgatg atgggaaatc tcagaaactt actcaagatg acataaaagc tttgaaggac 420 aagggcatta aaggagagga aatagttcag cagttaattg aaaatagtac aacattccga 480 gacaagacag aatttgccca agataaatat attaaaaaga agaaaaaaaa atatgaagcc 540 atcattactg ttgtgaagcc atccacccgt attctttcaa ttatgtatta tgcaagagaa 600 cctggaaaaa ttaaccacat gaggatacga tacactagcc cagatgttga cgttgggaaa 660 tatccgtgct ggcaacaaaa tgattgtgat ggaaacgtgt gcaggcttgg tgctgggtgc 720 aatgatggaa cgaatgggag gttttggctc cattattcag ctataccctg gaggaggacc 780 tgttcgggca gcaacagcat gttttggatt tcccaaatct tttctcagtg gtctttatga 840 attcccctct caacaaagtg gacagtcttc tacatggaac attttctgcc aagatgttat 900 cttcagagcc caaagacagt gctttggttg aagaaagtaa tggcacactg gaggaaaaac 960 aggcttctga acaagagaat gaagacagca tggcagaggc cccagagagc aaccacccag 1020 aagaccagga aacaatggaa acaatttctc aagatccaga acataagggg cctaaagaga 1080 gaggaagcaa aaaagattat attcaggaaa aacagaggag acaagaagag cagaggaaaa 1140 gacatttaga ggctgccgct ctgctgagtg aaagaaacgc agatgggtgc gttgatggaa 1200 gaaggcagga gactcctcag tgcatgtggg ctctgcttca gacagattgg cattctcttt 1260 ctccttgtct gctttgactc tagtgggacc cgagatgagg attttgtctt gggggttttt 1320 ttaaagaaag gaggctgagg ctggcagggg tggggaattg atgatgctgg tttcagggtt 1380 tcagaagaaa ttgaatcttc tccatcactg catcaagatg ggccctgtgg tcccactgga 1440 tgcaggggat ggggcactca aatgctgcga tacaggctat aacagatatc cacaaagcag 1500 cttatgcagt gttggatttg tttccaggtg atttttttta aaaaatcaag aatgtcatta 1560 aatgcgactt agagttgcca agtaccacaa gagcttctaa cctagttcgc gtttcctaga 1620 aagaaatagc tcatgattgt attctgtttt ggatttctag aatgttatat ttaaatctct 1680 tctctttgtg agtcatgcaa attaaataca tgatcatttt aaatgcattt taaaacctgt 1740 gctccacttt gagggtgtag agaaataatt tgtctggcat tttccttaca gtttaattgt 1800 agctagtcgt ttccacccca ctcccctgct gctgtctttg ctggactttg tggccccttc 1860 aaggccgttt gtggtctact gtcagtacaa agaggtaata ctggaatgga atgggcagga 1920 attcttatgt ctgaatgttg attcttaaac tgcatcccag gaagtagttc ttaacagaat 1980 tctgttgttg tctgcagcct ctgttggaat gctacacaaa actgcgggag aggggagggg 2040 tcatcaacct caggctgtct gaaacctggc tcagaaatta tcaggttttg ccagatcgaa 2100 gtcatcctaa actgctgatg agtggaggtg ggggttatct tctctccggc ttcaccgttg 2160 ccatggacaa ccttaaagca gacaccagcc tcaaatctaa tgcaagcact ttagaatcac 2220 acgagactga ggagcctgca gctaaaaaac gaaaatgccc agagtctgac tcttaaccct 2280 tttgagaatt gctctgaatt ttgttctcag gcattataca gttagtaatt aaactttaaa 2340 tgccattact acttgttttt tcatatccca agaataagaa catgtctatg tacccgtttc 2400 taggaaggag gagtatatgc cttttgtcta tttctgacac aagattgctt tgggccggtc 2460 aaaacctgca accatggggt atgtagtatg accaactgca tttaacaaaa ctcctctaag 2520 tacttctaaa tattctgtgc aaatatcttg agaacttcaa catcctaaaa atgtgtttct 2580 acaagacttt atattttaag ctaagtggaa taatacaacg taactaaaac atggcgggta 2640 ccgaaaggag ggcaattcat ggaagaaatt tcctctgttc attccgttct cttcaaccta 2700 agcaatatgg atgtgtgagt gtgtgattta ttatggtacc aaaaatgtcc accttctttc 2760 ctgcagcgga ataagctttt ttgaaatgct gaggttttat tttaatagtt gacaacctgg 2820 gaaagttctg agtatttatt ttactgctct ttttttgtgc atagaaaggt ttagtagggt 2880 actttttttg cattaatttg ccaatactct tattcatatg ttctaaaaaa agggacctgg 2940 aatttttgtg tactattcaa aaa 2963 <210> 60 <211> 2569 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:403872.1:2000MAY01 <400> 60 ccaggaggag gcagcggagg aagcagagcg cgggatgggg gcccagcggc atctgtgatc 60 ccgcgcacct ccgccccacg ggcgcgcgca caaacacgga cacacacata cacacactcg 120 cgcacacact cgcacaaaca cacactcgta cacgcccgcg gccgctcgct acgccggctt 180 gctctgggca cgcaagcgga atgcagcagc gcctggagag cgtgtctcgg accgccgcct 240 gaatgtacct cgctcccggg agccggacgg cccagtaggg cgcactggag gacgctccgc 300 tgcgggacgc ttggacagtt ttttgacggt gcagtcttgc tatatggtgt gagaaatggc 360 tgtaggaaac aacactcaac gaagttattc catcatcccg tgttttatat ttgttgagct 420 tgtcatcatg gctgggacag tgctgcttgc ctactacttc gaatgcactg acacttttca 480 ggtgcatatc caaggattct tctgtcagga cggagacttt aatgaagccc ttacccaggg 540 acagaggaag aaagcttcat caccccttct ggtgcctcta ttgtgtgctg gctgccaccc 600 caactgctat tatttttatt ggtgagatat ccatgtattt cataaaatca acaagagaat 660 ccctgattgc tcaggagaaa acattcttgg acggggaatg gctggttcct tgaaccccct 720 tacttcgaag gatcataaga ttcacagggg tgttcgcatt tggacttttt tgctactgac 780 atttttgtaa acgccggaca agtggtcact gggcacttaa cgccatactg ccctgaacgt 840 gtgtgcaagc ccaactgaca ccagtgcaag actgccaagc gcacccacca ggttagaaac 900 aatgggaaca ttttgtactg gggacctggg aagtgaagta gaaaaggctc ggagatcctt 960 tccctccaaa cacgctgctc tgagcattta ctccgccttt atatgccacg tatctatatt 1020 acaagcacca atcaagacga agagcagtcg actggccaag ccggtggctg tgcctcggaa 1080 ctctctgcgc cagccttcct gacaggcctc caccgggtct ctgagtatcc ggaaccactg 1140 ctcggacgtg attgctggtt tcatcctggg cactgcagtg gcccttgtat tctagggaat 1200 gtgtgtaggt acataacttt aaaggaaacg caaggatctc cagtccggac cacagcactg 1260 aggatcccca cgtcggagta cccctaatgc catcgtccca atggagtagc aaagtccact 1320 ctggataacc tataagtgca ccagagatca cttcttgggt cccaatggcc cggaaggtac 1380 cctgagagcc ggcgcttgaa tgtgtcaacc aaacgctgtt ttttgaaaaa ctagtcgttt 1440 ccccaagttc tatatgcact tccgaaacaa ccaccacggt tgcgtccaat gtcccaaccg 1500 tgggggagcc aaataattaa cggttaattc taaggtatag agaagctata atagttttgg 1560 aacacacttt ttgtaatgag aggagaatga gatgtatagc tttccccgga attttttttt 1620 tttttttggt cagctttaat atatttatgc cagaatttta aaacccaaca caaattttct 1680 tgttcaagcg tgcattgaag aaccacattt attcaatggt tgacgttgtt ttgtgatatt 1740 tgtacacaaa ttttcttttc tcagttttat aaacacagaa gtaaatataa caattcactt 2800 taaactttta ttaccacagt tgctgcctcc tccagaattt ttgaatttta ataaaaggca 1860 aacttttgag ctgcaggaag ggacaatgtc tggttaataa ctaaatctca gagtcaattg 1920 tagaacagac aacaattgtc ttcaagaaag aatgttggca ctcctgatct ccttaaacaa 1980 attgttacgt tcatatagtt tacacatgtg atatattaac caacatgtca ccatagttat 2040 accaaccaat tgtcagagaa ttctggattt ggagggtata tggggttata tgattctttc 2100 ttagataatg gcctctacta aactaactca agatctttct ggaatgtctt ctggcaggca 2160 ggtgccactg tcagcttttc tccaaaaagc aggccaacat cagcctcccc tgtcaactca 2220 acagttttgt atctcatatt atatggacct ttatatgaaa gatgaatatt ttaccagttt 2280 ggcacagtat tattttacag aaaaggaatc agagaatcct acaacatagg gccccagaac 2340 aacagtttca ctttgtggct ttataattat tctaggaatt ttaactgcat ctcatttttc 2400 tagcatggtg agaactaata tgtaactcct tttgattgaa ggagctcttt tgtccgtacc 2460 tatcaagaat gttttcttga cacttccatg ttgggctctt ctcagctttt tttgtacata 2520 tttttttttt ctaaagagaa gaacaaagtt ttcaccaaat tgtccgacg 2569 <210> 61 <211> 2545 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1086294.1:2000MAY01 <220>
<221> unsure <222> 2124 <223> a, t, c, g, or other <400> 61 gagcccgagg cggcagcgct cgcggccatc gtgggcccga gctgtgcgcc tcggctcgga 60 gcccggaccg ggcgggggcg ccgacgtgcc tcagcctgct tcgcgaggga ggcgggagtg 120 agcagaaagg cttagggccc agtgggcggg gaaggggggc cgggcctgga tccggcgggg 180 aggccgagcc ggaggccgga ccgtggctcg cgctgtcccc gggacgcgga tcgaacgttg 240 gcggcgcgga tcgcacgtcg gcggccggtg gaacgcggga gctgggcggc gcgcggactg 300 gggccatggc gtctgtgcag gcgtcccgcc gccagtggtg ctacctgtgc gacctgccca 360 agatgccgtg ggccatggtg tgggacttca gcgaggccgt gtgtcgcggc tgcgtgaact 420 tcgagggcgc ggaccgcatc gaactgctca tcgaatgccg cccgccagct caagcgcagc 480 cacgggctcc ccgagggccg ctcgcccggg gcccccggcc cttaagcacc cggccaccaa 540 ggacctggcg gcggcagccg cacaggggcc ccagctgccg cccccgcagg cccagcccca 600 gccgtcaggg accggcggcg gcgtgtcggg ccaggaccgc tatgacaggg ccacatcatc 660 aggccgccgt ccccctgccc tcgcccgcca ctggagtaca actctggggt ccccgcctgg 720 gccaatgggc tgggccgtga ggaggccgtg gctgaggggg cgcgaagggc cttggcttgg 780 ctccatgcct ggtttgatgc cccctgggtt gctggcagct tcagtgtctg gcctgggaag 840 ccgaggcctg acgctggcac ccggcttgag tcctgcccgt cccctcttcg gctccgattt 900 cgagaaagag aagcagcaga ggaatgcgga ctgtctggca gaactgaagc gaggccatgc 960 gaggccgggc agaggaatgg cacgggcgcc ccaaagcagt gcgggaacag ctactggcgc 1020 tgtccgcctg cgccccgttc aatgtgcgct tcaagaagga tcacgggctg gtggggcgag 1080 tgttcgcctt cgatgctaac tgcccgtcct ccaggatacg agttcgagcc tgaagctctt 1140 tcaccgaata cccctgtggt tccggcaatg tgtacgccgg cgtcctggca gtggctcgcc 1200 agatgttcca cgatgctctg cgggagccgg gcaaggcact ggcttcttcg ggcttcaagt 1260 acctcgaata tgaacgccgg'catggatcag gagaatggcg gcagctgggc gagctgctta 1320 ccgacggcgt ccgaagcttc cgcgagccag ctcccgcgga ggccctgccc ccagcagtac 1380 ccagagcggg gccctggggc tctctgtggc ccacccccgc gagccccatc ccggaacctg 1440 gcgcccacgc cgcgccgtcg caaggcatcc cccgagccgg agggcgaggc ggctgggaag 1500 atgaccaccg aggagcagca gcaacggcac ttgggtggca cccggcggcc ctgtactccg 1560 cgtgagaccc ctcggtgtgc cctcgcccat tgccgccctg aagaatgtgg ccgaagccct 1620 gggccactcg acccaaggac cctgggcgga ggcggggggc ctgtgcgtgc aggtgggcgc 1680 cagccctaac agcctaccac cacgagccca gaccgccaac cccagcatcg cctttgtggc 1740 cgcgcaacag gcgaagcagc aagtcagtcc cacaagcggg ggccgaagct gtcaacgggg 1800 gtggcagcag gcactggggc gacccctggg gcccaccctg tgcttgtacc ctgtgcaggg 1860 agcggctaga agacacccca cttcgtccca gtgcccctcg gtgcccggac acaagttctg 1920 ctttccctgc tcccgggagt tcatcaaggc gcagggcccg gccggggaag gtgtactgcc 1980 cgagcggaga caagtgcccg ctggtcggct cctccgtgcc ctgggccttc atgcagggcg 2040 agatcgccac catccttgct ggagacatca aagttaagaa agaacgggac ccctaggcta 2100 ccactgcctc caggctactg ccgntctgcc cctttgccac ccaccggctg ccgcggataa 2160 attattcccc tccccgaccc agcccagtgc cacctccatc tgggtggaat gaagggagta 2220 tgtacacaga tagaggtggc actggggtaa gatgcattgt gggtgggggg gagaaagctt 2280 gtggctcctg tccgaggggg ggtgtttggg ggtcccttgg ccccctccag tttccctcta 2340 gtcctccttg gcttggcttt gcttgctgct tgtagttagg gggagaaggt gcccccctac 2400 ctccttgaga atgggaccta cctgaaaact ctgctcttta taaactgagt gcaaaagcat 2460 tgtaattcca cacccccgcc acccccctgc gtcgccttct tgctccttca ataaaccgaa 2520 agatgggttt tttttttcaa aaaaa 2545 <210> 62 <211> 2114 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:337514.3:2000MAY01 <400> 62 agcggctgga gctgggcctt ggccgcgaga ggccggcgaa agctatcttc ctgcaccggc 60 ggccgggtga gggcggtggg agggagcggt gcctgcgctg tggccatgtc tgtgtacgca 120 agggggccgg ggccccgcga agctgtgccc tcaggccggc cccggccgga cacccttacc 180 cctccatggg tccggcagag ggcagtgacc ggcaccttct gtgcgtcctg gactcctctg 240 agaaacagga gagctcaaag gatggctact gacatgcaga ggaagagaag cagcgaatgc 300 cttgatggca cattgactcc ttctgatgga cagagtatgg agagaactga gagccccaca 360 ccaggaatgg cccagggaat ggagccagga gcgggccagg agggtgccat gttcgtccat 420 gcccgttcct acgaggacct gactgagtca gaggatgggg cagcttctgg ggacagccac 480 aaggagggta ccaggggtcc cccgccgctg cctacagaca tgcgccagat cagccaggac 540 tttagcgagc taagcaccca gctgacgggt gtggcccggg acctgcagga ggagatgctg 600 ccaggaagct ctgaggattg gctggaaccc ccaggggcag ttgggcgacc agccacagag 660 ccccccaggg agggcacaac cgagggggat gaggaggatg ccacggaggc atggcgcctg 720 caccagaagc atgtctttgt gctgagtgag gcagggaagc ctgtgtactc ccgctatggg 780 tctgaggagg cactttccag cactatgggt gttatggtgg cccctggtgt ccttcctgga 840 ggcagacaag aacgccatcc gctccatcca tgcagatggc tacaaggtag tattcgtgcg 900 ccggagcccg ctggtgctag tggcggtggc tcgtacgcgg cagtcggcac aagagctggc 960 gcaggagctg ctctacatct actaccagat cctaagcctt cttaccggtg cgcagctgca 1020 gccacatctt ccagcagaag cagaactatg atttgcggcg cctactctcg ggctcagagc 1080 gcatcaccgg acaacctgct gcagctcatg gcacgagacc ccagcttcct gatgggggcg 1140 gcacggtgcc tgcccctggc ggcggccgtg cgcgacactg tgagcgccag cctgcagcag 1200 gcgcgtgcgc gcagcctggt cttctccatc ctgctgggcc cgcaaccagc tcgtggcact 1260 cgtgcgccga aaggaccaat ttctgcaccc catcgacctg cacctgctct tcaacctcat 1320 tagttcctcc tcgtcctttc gcgagggcga ggcctgggac gcccgtggtg cctgcccaaa 1380 ttcaacgcag ccggcttctt ccacgcacac atctcttacc tagatgccta gacactgacc 1440 tactgcctgc tgcttgtctc cactgaccgt gaggacttct ttgcagtctc tgactagcgc 1500 cgccgcttcc aggaagcgcc ttcgcaaagc gcggagccca cctggccctg cgagaggcac 1560 tgcgcacacc ctactacagc gttgcccaag tgggcatccc ctgaccctgc gtacacttcc 1620 tctaataagt cacaagagct ctgggactct tccaccagcc cttgagattg aggccccata 1680 caccagtgaa gaggagcagg agcggctgct ggggcctcta ccagtacttg cacagtcgtg 1740 cccacaatgc ctctcggccc actcaagacc atttactaca cgggccccaa cgagaacctc 1800 ctggcctggg tgacaggcgc ctttgagctc tacatgtgtt acgagccccc tggggaccaa 1860 ggcgtcagcc gtcagtgcca tccataagct gatgcgctgg atccgcaaag aggaagaccg 1920 cctcttcatt ctcacgcccc tcacctattg atgggaatgt gtgcgggctc agccttcctg 1980 gacacactag gtgtgggaag ccataggagc ctcaacgatg ggggctggcc tctcttgccc 2040 gagccagcgg gcagggactg tgggttggta gaatgcatta aagtgctttg gggaagacaa 2100 aaaaaaaaaa aaaa 2114 <210> 63 <211> 2496 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:230711.1:2000MAY01 <400> 63 ggcagcatga gccgatcacc cctcaatccc agccaactcc gatcagtggg cgaccaggat 60 gccctggccc ccttgcctcc acctgctccc cagaatccct ccacccactc ttggagaccc 120 tttgtgtgga tctctgcctt ggggcctcag ctgtcttctg gctctgcagc atgtcttggt 180 catggcttct ctgctctgtg tctcccacct gctcctgctt tgcagtctct ccccaggagg 240 actctcttac tccccttctc agctcctggc ctccagcttc ttttcatgtg gtatgtctac 300 catcctgcaa acttggatgg gcagcaggct gcctcttgtc caggctccat ccttagagtt 360 ccttatccct gctctggtgc tgaccagcca gaagctaccc cgggccatcc agacacctgg 420 aaactcctcc ctcatgctgc acctttgtag gggacctagc tgccatggcc tggggcactg 480 gaacacttct ctccaggagg tgtccggggc agtgcgtagt atctgggctg ctgcagggca 540 tgatggggct gctggggagt cccggccacg tgttccccca ctgtgggccc ctggtgctgg 600 ctcccagcct ggttgtggca gggctctctg cccacaggga ggtagcccag ttctgcttca 660 cacactgggg gttggccttg ctggttatcc tgctcatggt ggtctgttct cagcacctgg 720 gctcctgcca gtttcatgtg tgcccctgga ggcgagcttc aacgtcatca actcacactc 780 ctctgcctgt cttccggctc cctttcggta tgtgtgggtc tgggcagggc agtagaggtc 840 agaagggctg gcctggagtg ctcactccat cccctacctt ttggcttctg tctacccctg 900 caaggctggc tcagaaggtt ttgggggagg agttcttttc tcagtctcgc ccctcaggtg 960 ctgatcccag tggcctgtgt gtggattgtt tctgcctttg tgggattcag tgttatcccc 1020 caggaactgt ctgcccccac caaggcacca tggatattgg ctgcctcacc acaggtgagt 1080 ggaaattggc ctttgctgac gcccagagct cttggctgca ggcattctcc atggccttgg 1140 caagcctgcc accagtgtcc ctggggctgc ttatgccctg tgtggccggc tgctggcatt 1200 tggcctcccc ccaaccgtcc aacatgcctg ccagtcggag ggctgagccc tggaggggct 1260 gggacagtgt tgctgggccg ggctgctggg aaggccccat gggcactgca tccagctttc 1320 cccaacgtgg gcaaagtggg tctatatcca ggctggatct cagcaagtgg gctcactata 1380 gtggggctac tctggcgtgg ggctatggac tctcacccca ggtttggctc agctcctcac 1440 caccatccca ctgcctgttg attggtgggg tgcatggggg tagaacccag gcatgtggtc 1500 tttgtctcgc tggattctcc cagcttctac ctggcatgac atagactcct tgggccgaaa 1560 tatcttcatt gcgggcttct ccatcttcat ggccttgctg ctgccaagat ggtttcaggg 1620 aaagccccag tcctgttcag cacaggctgg agccccttgg atgtattact ggcactcact 1680 gctgacacag cccatcttcc tggctggact ctcaggcttc ctactagaga acacgattcc 1740 tggcacacag cttgagcgag gcctaggtca agggctacca tctcctttca ctgcccaaga 1800 ggctcgaatg cctcagaagc ccagggagaa ggctgctcaa gtgtacagac ttcctttccc 1860 catccaaaac ctctgtccct gcatccccca gcctctccac tgcctctgcc cactgcctga 1920 agaccctggg gatgaggaag gaggctcctc tgagccagaa gagatggcag acttggctgc 1980 ctggctcaga gggagccatg ccctgaatct agcagagaag ggtttaggtc cctagaaatg 2040 taccagtaac gccttacttc tgccctggtt aattttagcc cttatactct ctatctgctg 2100 gagagtcagc tcccttaact gttctttctt gtaggcagta ggatatgtgt gtgtgtatta 2160 catgggactg tctagaggtt cctatttccc aatagggtgg gttgcctttc cttgtcttaa 2220 ttaggcctaa ctgttccaga gcagaggcca tgatttagtg gaccatgaat gattgagatt 2280 ttgcgctgtg tactatcaat gccacttgaa gccaagcatt cactttaata cttactgagc 2340 atctcccatt gtgcaaggtc ctggaactac acgggataag acagggtcca tgccgtctcg 2400 aaggcattta cggtttaaaa agacctttgt aattactaac gaaaatgcaa agcagaaagc 2460 agtctgtaat aaagattaaa ataatgccgt gggagc 2496 <210> 64 <211> 1377 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:040338.2:2000MAY01 <220>
<221> unsure <222> 849 <223> a, t, c, g, or other <400> 64 gtcgcggcgg cggggaagga ggggtgcttc aggtgcctgc gacctccgcg cctcccggtc 60 ggaagtgccc gaggtggccg cgatggagct gggggagccg ggcgctcggt agcgctggcg 120 ggcaaggcat ggcgccatga ccctgattga aggggatggg tgatgaggtg accgtccttt 180 tactcggtga cttgcctgcc ttactggtgc tggcccttgc ctgaggtctc aacgcacacc 240 gctgagaggc ggggacccac ttgccccagc ctgtcaggga ccccaactgc catcccagcc 300 cagcgcagcc atgggcaggt taccgacagc atgagagggg aggccccagg ggcagagacc 360 cccagcctga gacacagagg tcaagctgca cagccagagc ccatgcacgg ggttcacagc 420 aacaccgcca gccccgggac tccccgcagg agccccatcg tgctacggct gaaattcctc 480 aatgattcag agcaggtggc cagggcctgg ccccactgac accattggct ccttgaaaag 540 gacccagttt cccggccggg aacagcaggt gcgagctcat ctaccaaggg caagctgcct 600 aggcggacga ccaccagacc ctgggcagcc ttcacctccc taccaagtgc gttctccact 660 gccacgtgtc cacgagagtc ggtcccccaa atcccccctg cacgccgggg gtcccgagcc 720 cggccccctc cgggcgtgaa atcggcagcc tgttgttgcc ccctgtgctc ctgctgttgc 780 tgctgctctg gtactgccag atccagtacc ggccctttct tttcccctga ccgccactct 840 gggcctggnc ggcttcaccc tgctcctcag tctcctggcc tttgccatgt accgcccgta 900 gtgcctccgc gggcgcttgg cagcgtcgcc ggcccctccg gacccttgct ccccgcgccg 960 cggcgggagc tgctgcctgc ccaggcccgc cttttcggcc tggcctcttc ccgccgccct 1020 ggagcccagc cctgcgccgc cagaggactc ccgggactgg cggaggcccc gccctgcgac 1080 cgccggggct cggggccacc tcccgggggc tgctgaccct cagccccgca ctgggagtgg 1140 gctcctcggg gtcgggcatc tgctgtcgct cgccttcggc cccgggcaga gccgggccct 1200 cccgggggcc cgtcttagtg ttctgccgga ggaccccacc cgcctccaat ccctgacagc 1260 tccttggggt gagttgggga cgccaggtcg gtgggaggct ggtgaagggg agcggggagg 1320 ggcaaaggag ttccccggaa cccgggcaga ttaaaggaac tgtgaagttt tcaaaaa 1377 <210> 65 <211> 1445 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:399174.2:2000MAY01 <400> 65 gaaaccaagg acaatgtgtc ctttaaaagt gtaaggttag aaggtgccct gactccagcc 60 gacctggaaa aggacgtgtc ctgcatatct ggaggtggcc cacagggtcc gggaaagatc 120 ggctgccttg cctgcatccc agggcgcttc ccggcctcca ttaagaggtg accattgcat 180 ccacgtgatt tcttttgctc cactatttcc aggcacagtg caactgactc cctcttgaag 240 ctagaatgcc ctgcacaccc gggatggact tctctcccct ttcaaagatc gagtgaagtt 300 atgcaaatgt gaaaggaagg aattgcattt ccagtggtaa cctttgaagg ggaatgacat 360 tgtcacagga cgtcaggagc cacgtggggg gagcccggtg tcctctgagt ctcaacgcca 420 ccttgcattc ccgcttggtg acggtcgatg ggctgtgtcc agcggtgaac gctttacaca 480 aggactctac ggtggggtag gcaagcgcca cttcaatgtg aagacaaatg aactggcgtc 540 tcttgagata tgcccctgcc tccaggacct ctcaggcccc gggccctggt tactgccgtg 600 gaagctgcct gttcagacgt catctctatc accccttgaa gggagacaga gaggtgtttg 660 cgagttggat gttttatctt gtctttcctg attctttgtt agaacacccc cagggcttgg 720 tttttgttct caacctgtga ttagaaataa gatcctaaag tgtcagatct ggaaggccca 780 tgagagctga ggagatcaaa tgcccggagc tcgggagatc agatgacctg gggtgtctgg 840 agccagtggt ggcctcatct gcagcatctt cctctgtcct gcccaccaca gagtccctgc 900 tggccccggg gggcccctct tccgccacag ggcccctgag cattgctgcg tttgtttctc 960 cagctcctcc ttcctgcaga agcagttccc agaggggcaa tttctccagc ctgcctggtt 1020 ggttgtgttg attggttata gttgctcttt caggtgaccg cagaccctct gaaggctgtg 1080 gccgtgggtg tggctctatg gccacctctc tctcttctcc tctcccaggt cgcgtctcct 1140 tcttcacctc ggggtccgag aacctacacc gcgtggagaa ggtccactgg ggcacccgtt 1200 acgccatcac catcgccttc agctgcaacc ccgaccatgg catcgaggac ccagcgttcc 1260 cgtagccagc agccgggcca aggtaacttc aggagggccc gtgtggaggc agccgcgcca 1320 gtcgtgcacc cacccccacg tccacccgct cctgttgcac agagtgcctt aggaattctc 1380 tgattttgat ttgctgacgt gttaatcttt tcatctgtga gtaaatgaag ggaaccagca 1440 aaaaa 1445 <210> 66 <211> 1578 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:197275.5:2000MAY01 <400> 66 cagtgctctt cagcatctgg agtctttgca gaaacagtat ctttttgtgt ccaataagac 60 aggaacccta catgaagcct gtgaacagct cctaaaagaa cagtcggaac ttgttgatct 120 ggctgaaaac attcaacaaa agctttccta ttttaacgaa ttggaaacta ttaacacaaa 180 attgaattcc cctacattgt cggtgaatag tgacggattt atacctatgc tggccaagtt 240 agatgattgt ataacatata tctcatctca tcctaatttt aaagattatc ccatatattt 300 gctgaagttt aaacagtgtc tttctaaagc tttgcacctc atgaagacat atactgtgaa 360 cacactacag accctcacaa gtcagttact gaaaagggat ccttcatctg tacctaatgc 420 agacaatgcc ttcacattat tttatgtgaa atttcgagct gctgccccca aagtcagaac 480 tcttattgaa caaatagaac tgcggtctga aaaaatacct gaataccaac aactgctaaa 540 tgatatccac cagtgttacc ttgatcagcg ggagctcctt ttgggcccta gtattgcttg 600 cactgttgca gagttaacca gccaaaataa tagagatcac tgtgccttgg ttcgtagtgg 660 ctgtgccttc atggttcatg tctgccagga tgaacaccaa ctttacaatg aatttttcac 720 aaaaccaaca tcaaaattag atgagctttt ggagaaactg tgtgtgtcat tgtatgatgt 780 cttcaggcca ttgatcattc atgttattca cttagagact ctgtcggaac tttgtgggat 840 tcttaaaaat gaggtgctga agatcatgtg cagaacaatg ctgagcaact gggggcatcc 900 gcagctggag tcaagcagat gttagaagat gtacaggagc ggctcgtcta ccgaacccac 960 atctatattc agacggacat cacgggctat aaaccagctc ctggagatct ggcatatccc 1020 gataagttag tcatgatgga gcaaattgca cagagtttga aagatgaaca gaagaaggta 1080 ccttcagaag cttcattttc agatgttcac ttagaagaag gagagtctaa cagtctgaca 1140 aaatctggtt caacagaatc cctcaatcct agaccacaga ccacaatttc tccagcagat 1200 cttcatggaa tggtggtatc ctacggttcg aagaactctt gtctgtctct ccaaattata 1260 cagatgcata gatagggcag tgttccaagg attatcacag gaagcattgt ctgcctgcat 1320 tcagtccctt acttggagcg tcagagtcta tcagcaaaaa caagactcag attgatggac 1380 aacttttctt aattaagcac cttttgatac ttcgtgaaca aattgctcca tttcacactg 1440 aattcaccat taaggaaatt tccctggacc tcaagaaaac tagagatgca gcatttaaaa 1500 tcctgaaccc tatgactgtc ccaagatttt ttaggctgaa tagcaacaat gccctgatag 1560 agttcttgtt ggagggta 1578 <210> 67 <211> 1738 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:336872.1:2000MAY01 <400> 67 aaaatagtca tccttaactg gtttggacca tctttcatta gtaaaatcaa aagcatatgt 60 gcacagtaaa attcctagct gcagacgcag gctcacctcc cacagccaac cccttagccc 120 cttgaactgc tcgcatgagg acctcagaca cacttctcta aacacccctt ttcatatgaa 180 aatactggag gcagagtgtc cttccatttg tgggtttcta tttttatttt tgagacagga 240 tctcagtctg tcacccagcc tgtgatcgca ccactccact ccagcctggg caacagagtg 300 agacttagtc tcaaaaaaaa gggaaggttg aatttttact tcatattcac ccccaattaa 360 cttcagttgg attaaagagc taaaactaga agcaaagttt ttcttctaaa acattggaag 420 acaatattgc attttttata atcaaagggt ctttctgaaa gtgacacaca agtcccccat 480 ctgtaaggga aaagtttgag atttgagtat gcaaattggt attttccata agacaaaaga 540 aagcataaag gaaagcaatg agctgtataa aatattcaca aaatatctat ccgaagatgt 600 atatcagata tattgagaga ccctaacaag atcagtaaga cagaaagaaa ctcacttaaa 660 aaaagtcagt gcgcttttct acattttttc ccaaaataaa aggattggca aagcacataa 720 gcagaccatt catcaaagaa gtaaagatga ctgattaata agaaaaagat ggtaacatca 780 ctaataatca gtaaggccag gcacagttca tgcctgactt tgggatccct tgaacccagg 840 agttcgagac catcctgggc aaaatggcga aaccccatct ctacaaaaaa tacaaaaatt 900 agctgggcgt gatggcacgt gcctgtggtc ccagccgctt ggggggctga ggtgagagga 960 tcacttgagc ccaggagttc aaggctgcag tgagccgtgt ttgcgccact gccctctagc 1020 ctgagtgaca aagtgagaca ctattaaaaa aaaaatcagt aaaatgtaaa tccttgcatt 1080 cctgatgttg atacgcatgg cttctttttt aaaaacgttc agtcttacta gaggttctca 1140 aataattttt tcgagagcgc acagctcccg ggttcattca tattccacat tttggtgttc 1200 aaattcaatg aagtctgctt tttggtcttc ctttgttctg ctaattgttg gggtcacact 1260 ttaacttaat cgctttttgt cggtatctcg gtggaaagct ccacgagagt aattgaattc 1320 tgagaaaccc tctttgtgca ataaataaaa agacacctct ccataggcca tgagtaatat 1380 gttccctctt catagacacc tggcacatat atctgggggc ccacacggat atgttaataa 1440 taggctcata aatattgcaa ctttcttctt tgccctctgt gtaagaataa agagtttctg 1500 gaatattttc ttggagaaat ctctctttgg ggaattaatt atagacatat aggtgtgtta 1560 acattcccag gcgcaatatt ctagagatcg tccctggtat cccctcttaa tacatggaaa 1620 tttagagtcc aaatcccaca tatgggccag aaaacaataa cactttggga taggaattca 1680 ggttatttta caatcaatta agagttattt tataaacccg ggaaaaaaaa aaaaaagg 1738 <210> 68 <211> 640 <212> DNA
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1092901.1:2000MAY01 <400> 68 tttaggaaat agtataggag atacatgatc aagaatttat ataagatggg gttaatcaag 60 aaatgagagt aaaataagaa taataatggt aataattttg aacactgaca aaaggacatt 120 gatgacacag atctactttt ttcaggtctt caaaatgttt cttctatgtc attaggatga 180 acacacattt cacatgttat ctttcaaaag gccttttgtt ttcaagctgg cattggaatc 240 tcagccaaca tctttcttct tctctggcac atttttacat tctttaagga tcacaagcct 300 aaaaaaccat gacctgatca tctgtcactt ggtttctgtc tacatagtga tgctagtcat 360 ggcagcagag ttattgtctc tagacgtgtt tgcgtcacag aattttcaga ataacttcag 420 atgtaaggct gtgttctaca tatacaaggt aatgaggggc ctcttgatct gcaccacctc 480 tctcctgagc atgcttcaga tcatcaccat cagccccagc acctcactgc atagtcgtga 540 aatcggcaga attcccgata agctctccaa ccacgtattt tctgcgtttt tgatccagac 600 ccagatggta ctgctctggc agactcttct ggtactcttc 640 <210> 69 <211> 1950 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:022387.5:2000MAY01 <400> 69 tgctttgggg tcaggtgtgg agatcagggt cggggaggtc atgaggtagg taggggtcag 60 gatgtggaca gtcatgggct ggtgggtgtg gcagccgtga ggggtgggtg gtggcctggg 120 aggcagggcc tgggcagggc ttctgcactt ctgctgctta cccagccccc tctgggttcg 180 aggactctcc ttgacaaggg ctgagctctc gggcactgcg ttggactcag ctgcctactg 240 ggaggctggg gagaatggac ctgtgagacc ttgtttgtcc tcttccctgc ccagctcttg 300 tagaccccag gcctggctgt ccgcagggcc aggagctgca gccatggcag ccaccagcct 360 cccacatgag ccccagctcc cagccccaca cgcccactcc tttgcccatg tggtgtcagc 420 tctggcctcc gcttccacac atggaccctc agaccttgca catctgttgt ttcccttgca 480 gggcagtgat gatgacatga aatgaggtgg ggtcactcct gtttagggat gagactgggg 540 cccagggagg ggcaggtgtg aagttgctga gggcagaggg agacccaggg ctacctgctc 600 ctaatgacca gcctcacgtt ctccactgct cactccctgc cgttcaccag ctgcatgacc 660 ttgagcagtg cactcaactg taaacagagg tgaaaacact cctttaccaa ctgttttagg 720 ggccactctt gtttgaggcc ttgaacctcc tttcagttcc gtggtggtcc tgagcctctg 780 aatctgggta tggcccctgc tgggtcctgg tctcttaggc agcacgatgg cctccctgct 840 caaggccctg cacccagggg cagattgtgg gaggcccact ggccatggct gggccctatc 900 gcagagagcc tgtcagcacg gccatttcca cacccaggct ggctgggaag caagctacga 960 ggtgctcaaa ggccctctat gtctgcaggt agccccgtcc cacacaggcg aggatcgttg 1020 ggcctcctta gtagccaaag gaactgaggt ccagagcagg gaatgtgttg cccagtgtca 1080 gcatggtctg ctctggggtc aggcgtcttg ccctggtcct aagccacccc aagccaaggc 1140 atgtccctgg gcccatttcc tctctcgagg tcttgggttc cctatttctg atgtgtgtga 1200 aaggaaggcc tgtcctctgg ggtgaccatg aggctcagtg ggaggagctg ccaggcttga 1260 gctgggactt ggcacctggc cagccttttt tctatttcat tgtaccttga tgggctgtca 1320 gttctgaaga gaaaaaatac actaggaatc cattcttcct ccaccattct ccctggcaga 1380 gggaagtgac tacaccccta tggtgtggac atactgacgc tcctccatga agcagcaaag 1440 ttctgttgtt tcaggagact gtgggccttg aggatgtggt agtgacctca ccagaggagg 1500 tggcaattcc taagtgctgc ctggaggcct ctacagagac ataatgttgg agaacttctg 1560 ccacatggca gtgctgggta agacccctct gtccccacca gtgcccttaa ggttatgggt 1620 gttggtaggt ctgtggcctc catttccatg acgatggtgt taaggactca tgtttgtgtc 1680 cccccccaaa gtttatatgt tgaaaccctg acccccagga gggtggtatt aggaggtggg 1740 gcctttggga ggtgactagg cttaggtgag atcgtgaggg tggggctcgc cgatgagatc 1800 gagtccttat aagaaaagga aggaactaga gcgagatcac tttgtgctgt gtgagcatac 1860 aagaaaactg ccatcttcaa gctgggtgca gtgctcacgc ctgtaatccc agcactggaa 1920 ggccaaggca ttaggattgc atgatccagt 1950 <210> 70 <211> 597 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1188334.1:2000MAY01 <400> 70 gggatttgtc ttcttgcact ttattttttc tgaaatgtac attgctagta tttgtgtaag 60 ccaagtggtt aatcttttca taaaaatgca gtcttaagaa atcttaacaa aatttggatt 120 ttaaaaaagt tgatattaga cccagtgaaa gaactacttt ttttactgtt atgttttgtt 180 tttcatgatt ttgtatattc ttcaggacaa gcagtgggaa gagctctgtt atcaatgcaa 240 tgttgtggga taaagttctc cctagtggga ttggccatat aaccaattgc ttcctaagtg 300 ttgaaggaac tgatggagat aaagcctatc ttatgacaga aggatcagat gaaaaaaaga 360 gtgtgaagac agttaatcaa ctggcccatg cccttcacat ggacaaagat ttgaaagctg 420 gctgtcttgt acgtgtgttt tggccagatc atcttcagtg gctattcgat caagttccgg 480 attcttatat gttgcttcaa caaaatgtga tccttcagta acaaactcca gtaactggtc 540 aaagattgca gtaatcgcct tcttagccag cacaaagtgc ttcagtggag aaacagg 597 <210> 71 <211> 963 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1188664.1:2000MAY01 <400> 71 gctttcgatg gcctccctag gatggtcatc cagaggataa gccaacgcac atcatcttcg 60 gttctgacag tgaatgtgaa acagaggaga catcgactca ggagcagagc catccaggag 120 aggaatgggt gaaagtaaga agttcaggat gtctctgtgg acattcatct acttcagcag 180 atccccatta cgaacaactg gcaaactcaa cataaaaccc tcctgagagc cccaatgaga 240 cccagggctt gccaggtcac ctcatattga gactacaggg gtcttggaga tttttatata 300 tgaacctata ttctccacaa catctgcagc atgacatcaa tattagtgaa acgctacaaa 360 aactgttctt gcatgtaata actacctccc caaatccagg cttcactgga gagcctctgg 420 attagtgatc ccagaggcca gttagatttc actgagtcag gaatttccac ctgacctgcc 480 atttactcat tcctggtaga tgagtctggg ttactggctt tcaatgtgag ggagaagatt 540 acgttatgaa gggaaatact gcttgtttgc cctctgccta ttaataaatg ttgtgtttcc 600 ttcacaggag tcctatgggt aaaacatcag ggaagctgtt tgatagcagt gatgatgacg 660 aatctgattc tgaagatgac agtaataggt tcaaaattaa acctcagttt gagggcagag 720 ctggacagaa gctcatggat ttacagtcgc actttggcac cgatgacaga ttccgcatgg 780 actctcgatt tctagaaact gacagtgaag aggaacagga agaggtaaat gaaaagaaaa 840 ctgctgagga agaagagctt gctgaagaaa aaaagaaagc cctgaatgtt gtacaaagtg 900 ttttgcaaat caacttaagc aattctacaa acagaggatc agtagctgct aagaaattta 960 agg 963 <210> 72 <211> 1365 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:247388.1:2000MAY01 <400> 72 tttgccaaaa gttggggtca tccaaagaaa tatctgtcct gtttccagaa gcaacaaagc 60 ttgccttagc aaaggtggaa ccttttcctt cagattcaat ggtgatggtt gtagttcgtc 120 ttaacaagat ctggtcaatg tcctcttcac aaaacttgga gccttcatca tcttcctcca 180 tgatggctgc atatgctcct tttcttaaaa catcttcaat ctccttctta gagaactgtt 240 ggattccagt aatgttgcca tcccgaccac tcatggattg aagcacagcc ttatccaacc 300 ccaacttgag gctggcctta tcaaacatct ctctctcgta ggaattacga gtgatgaggc 360 ggtacacctt cacagctttg ctctgcccaa ttcgatgaca tcgtgcctgg gcctgcaggt 420 cattttgtgg attccagtct gaatcaaaga tgatgcaggt atcagcagct gtaagattaa 480 taccaagtcc accagcccgg gtacaccagt aagaagacaa agcggtctga gtcaggcttg 540 ctgaagcggt caatggcagc ctgtcgaagg ttgcctctaa ctcgcccatc aatacgttca 600 tataagtacc tcctctggat taaataatcc tctaggatgt ctaggcagcg taccatctga 660 gagaagatca gaactttatg gccaccagct ttaagctttg gaggcaactt gtcaataaga 720 accagtttgc cggctgaacg aaccatggcc tgcaggtgaa aggtcatgag gtataatatg 780 gcaagcttca cggaattctg ttaggatttt ttcttcagca ccagcttttg gaaagagctc 840 actctagctg ctatgataaa caagaacgac cagtgaggaa gttttgaaac tctcctctgc 900 aagagaatgg tggccagcca ggcgtggtgg ttgtcgaatc tgtggcacct gtgggaagtg 960 ggctcagcca cagggactgc catttggatc ccccagcatt ggcaccatac ctaccctggg 1020 ccctaaggtg gccatgcttc tctggatttg cttccctagc agtgagctct agtgcttgca 1080 cacatccctg cccacagcat ggcctgggag cagctgagac tggagggcca gctcatcccg 1240 cgtctgattc ctgtgaagtg ttatcagtcg cctgttatgg agtgctggac ccatgagtgg 1200 cagccttccc tggcagctgg gctgacctgt ctagcttttc cattgctcgc tggttttgtt 1260 cactgtaggg cgtgaggggg tgagtagctg ctggcctcca agtcacatag ctactcatgt 1320 tgtacgctgt tcacagggac ctctaaggat gtacatcatc acaca 1365 <210> 73 <211> 1728 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:816339.4:2000MAY01 <400> 73 gggctaggtg tgggaaacag ggaagagaac tagaactggg aagtaaagca ttgaagatgt 60 ggactggaat tgctgcaatc tcatggattc aaatttgaat gggatgaggg agttgcttct 120 tatggatgag cacagaaaag tggttttttg agatagaaat tactcctggt gaagatgctg 180 tgatcattgt tgagatgaca acaaagaatt tagaatattc cataaactta ggtgataccg 240 cagctactgg ctttgagagg actgactcca attctgaaag aagttctgtg gataaaatgc 300 tgtcaaacag catcacatgc tacagagaaa tctttctaga aaggaagagt cagttgatgc 360 agcaaacttt attgttctct aagaaattgc cacagcttat cgtaatcttc aaccaccacc 420 accctgatga gtcagtaccc atcgttaacg ttggcgtaaa accctccacc agcaaaaaga 480 ttgttacgca ttttttaacg cagtgatgta tttatcaatt attcattatg ctatttgtac 540 cctttcttaa tagactatgg tatagtgtaa ccataattta tgccctggga aaccaacaaa 600 ttcatgagat tcgctttatt gtagtgctct ggaattgagc ctgcccgggt ttcttgaggt 660 atacctgtgg tatttagtat gttccttgta tataacaccc cattttatag ggtaggaaac 720 taaggcttag agtttgagca attttcccat agataacacc aataaattga gggctgcaga 780 gaccacttaa gtggttctct taacagtagt ctagacatgg acgtaatgag atttggctta 840 ggagtgacaa tggtaaggaa gttaaaggat tcaggaacca aataccagtt attgagaaga 900 aagaatggcc tcaaaaacat cacttctcaa ggaagccttg ataccctcac ccttactaca 960 ctgtatcctc catttgaatg ttgtcaagag ctcttctcac aattgtaaat aataattgtg 1020 taattttgtt ttttttttcc tactttaggt tgctccttga gggcaggaca gttcttatgg 1080 ctttatccgt tgcgtaaggc acagagaggt ctgcgaggtc aaaactattg tcatgatagc 1140 aagatgcctg tctttttcat ttattctcac ggtgtgcaga ggcctacatg atggtgtgat 1200 gacatcctca ttgatgttaa tgaatggtgc tatacttgaa ttttctaagg tgtcattagg 1260 taggtttagg tattgcatac ttgtttttag aaattatttt tttccttttt cccattttta 1320 gaaatcaact cattttttag gttatgcctt cagtaatctt tgcaacctca atattgtgta 1380 atggttactt taaaatactg tagttttctt tgtgcctaag tataaacata agtacatttt 1440 gttgttttgt attgcaatag tggtttaaat attttcccta aatatccaaa tttaaaaagt 1500 ctaaaacttt agaatttaat aaatttattc taaaatattt atatattttt tcatttaaga 1560 atggatcggc ttaaaaacac tgcttctcat ttacttactg gctataccat ctgtatacta 1620 ataaaaaaca agatttgatt tggaaggact gactcaaact aacgaaaata tgaaacctgt 1680 ctttctgctt tggagatatt tacctaatca tgttctgcag tagaataa 1728 <210> 74 <211> 747 <212> DNA
<213> Homo Sapiens <220>

<221> misc_feature <223> Incyte ID No: LI:1188967.1:2000MAY01 <400> 74 atgagcttac agaaagcctg gcttacattt actctgtttg gatttcttcc tcatcaagag 60 actgctgcag tgcctgtcat gtgacagcgg catggacata tgccccaggc tttcctgctg 120 gggtccatcc atgagcctgc aggtgccctc atggagcccc agccctgccc tggtaagctt 180 ggctgagagc ttcctggagg aggagcttcg gctcaaatgc tgtgagctgg agccaagctt 240 gcaggttttc gggagccttg tgggcgatca atctacaatc ccggtggcag ttatgctatg 300 gcgagccgac atctgcaagc tactgtgact cgtgctactg ccaagggccc ccagaggaag 360 tactcttcct tgggcatgaa cccttggacc tttttggcat ggcccaagat ctgtggtgcc 420 cttttggggc aagtaagcat gggtccgggg acgtggttgg gcattttgtg gggccctgtg 480 cgtgacccct tcgcccaaga gcatcctaaa cgacccagtg cctgggactg gagtgcccac 540 agtcagaagg acccaagaca aagcatggga catgaaattc aagagtgaac ttcttcatgc 600 ggaggctgca gctggatcag aggacacaat cccactgtga cagaagtgca agtcagaaga 660 cctggctttt catcccagct ttgaaacttg gaactttttg attgacaaat taataaacct 720 ctttatgccc caggctcctc ctctgtt 747 <210> 75 <211> 1817 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LT:236230.3:2000MAY01 <400> 75 tcgaagttca tcatccataa tgtatatagt gttagcaagc agggagttgt tattcttgat 60 gacaagtcaa aagaacttcc tcattgggtg ctgtcagcta tgaagtgttt ggcaaattgg 120 cccaactgtt ctgatttgaa gcagcctatg tacttgggat ttgaaaaaga tgtctttaaa 180 accatagctg attactatgg tcacttgaaa gagcctctac ttacatttca tctttttgat 240 gcttttgtca gtgtactggg tttgttacag aaggagaaag tggcagttga agcatttcag 300 atttgctgcc ttctcctacc tcctgaaaat aggagaaagt tacagctatt gatgaggatg 360 atggcaagga tttgcttaaa caaagagatg ccacccctgt gtgatggctt tggtacccga 420 acactgatgg ttcagacatt ttcccgttgc atcttgtgtt ccaaggatga agtggacttg 480 gatgagttat tagctgctag attggtaacg tttctgatgg acaattacca ggaaattctg 540 aaagtccctt_tggccttgca gacctctata gaggagcgtg tggctcatct acgaagagtc 600 cagataaaat acccaggagc tgatatggat atcactttat ctgctccatc attttgccgt 660 caaattagtc cagaggaatt tgaatatcaa agatcatatg ggctctcagg gaacctctgg 720 gcagccttgt tggaggaagt cataacagat gccaaactct ccaacaaaga gaaaaagaag 780 aaactgaagc agtttcagaa atcctatcct gaagtctatc aagaacgatt tcctacacca 840 gaaagtgcag cactttctgt ttcctgaaaa acccaaaccg aaaccacagc tgctaatgtg 900 ggcactaaag aagcctttcc aaccatttcc aaagaactag aagttttcga atgtaataat 960 acttccacag caacaggtgc tagagaccac tgtttgttgt tttgagtgaa tggtggttag 1020 ggggaaagac tttggtggtg gaagaaagaa aagcataaaa caaagactac tgaaatatta 1080 gataaagatt gccttagttt ttaaaaatgt ttggccatta gtatttttat aaaactcaat 1140 gctagtttta aagtgtataa attggttaaa atttatgagt caaatatata gtgataatgt 1200 taacatgttt gtaattgcta cagaatttaa gggtattttt atctctgtgc tctctttttc 1260 atggtgttta ttaaataatt gtgtatatac atccctagct actgatatct ttattatagc 1320 cttaagactt aattttaagt cttaaaaata gccgtgtata cttgaataag aaagacactg 1380 ggtactgtta ctgtgatgct attgacttag tagccaatta tcatttctcc tgtataaatt 1440 ccagttttta ttgctgcaca taaatttttt aatgtcttat attgtgatag ctatgtcttt 1500 tattgcagat ttattggatg ttatgacaga ttttactaaa gctagtgatt tttatgaaca 1560 tatatattag atgcatgatt tacctataag tggagtagat tttcatctgc cctgcaatgg 1620 tataatttca gtcttagcta aaaatggaaa gttgaactgg gataaattct ttggggtacc 1680 cttaggacct ctgattctaa gtcaaatgca aatggggtta aataaaatga ggactacttc 1740 ctttataaat atattttcat ccttttggaa agtaagtgaa atgtaaaata aacttatttt 1800 tttttaaaaa tgccaaa 1817 <210> 76 <211> 2683 <212> DNA
<213> Homo sapiens <220>
<221> misc feature <223> Incyte ID No: LI:246728.3:2000MAY01 <220>
<221> unsure <222> 2339 <223> a, t, c, g, or other <400> 76 ttaagaagac agtttagcac agagatggca ccagcctggc cttccctact gtcccagggg 60 agcagagcta gggtcctctt ttaccctccc taaggtcacc cccttcccat ctacacgtcc 120 ctccccaagt tcaagcacat agtcaatcat gaccactcag gagctcagtg agctggggcc 180 atgtccctgt ggcctccagc ccatccgcag gagggtccct tgcagtgaca gcacaaagag 240 tccccctaca gtgaagcccc tgtagggcca gcatggacct tgagagccag gagggaatgg 300 gcctggtgcc actctgttcc cactcccacc taagattcct acccctgtgt tctagcaggt 360 gactcttgat ctggccagcc cacaacaaat acttgaacta ggcagcatgg ggtggttgga 420 ggcctgcaga ggcccactgg gcccacggaa ctgagacata gggctttctc atgaggcctg 480 atcaagctcc cgcaggtatg acctggcctc ctcgcctcgg gctgccttaa agcaccgcta 540 acccacgcca aggggctagg cagggcttcg cggggcctgg cccaaggtct ccagcagagc 600 aataacatct tcccaggttg ggttgccaca gacaccctgc cctggagccc ccagcccatc 660 ccatctggtg ctaccctgtc tgcctggcag cctagcctca cccctcctgt ccggtcatct 720 gggggtcctt ggtaaggatg cagccacatg gggccggttt atgcacctgg gcgagaacct 780 gactggggca ggggatgctc aggggcctgc aggtctccca cagggctgct tttctgcccg 840 cctcaccctg tgggtttgta tttcttgccg ggtcaaaata ggcagtgact cgtgccttcc 900 ctcctcaggg ccggcggcag ggtgtggacc cagctggccg ctggaccgtc cccttcctca 960 ttctccaagc tcatcaacag gtctcagagg aacatttcca taaaaggtgt ggcctggcat 1020 gcagtgctgt ctgcacgctg tcgcttcccc cacagcaacc tgccggtcag ccttaactgg 1080 tgtggaggtc gaggtgggga gggggaggcg ggcttccctc cctggtgtct ggcctctttt 1140 tgctcagccc tcagcacagc cttcagcgtg gagagcgaga ccctgcgtgt cactggggct 1200 tggctgaggt ctcccctgca aggattaaca agtgacttca aggaacccag accccagtct 1260 ggggcggttc taccttcccg gctgggccca gcccccacac cacagtaccc tggccacgct 1320 ccatggcaca aaagcctctt gaggccacag ctcagctatg aagctgatgt ggcttatgtg 1380 cagtctcctc agggaagggg gcagtgatgc catgcatgag atccgctgtg ccataagaaa 1440 gttgcttcct ttagaatttc tggtccaatg cagggaggtg aggcccagcc tcatgcataa 1500 cacatgccca tccaaggaaa agctgtggct aatgcttcca aaacaagtga aaatcttgca 1560 ccaggcccca ggggccatat ctcattccgg ccccagctta ctgagggagg ggacagactg 1620 ctggaggaca atttctccta gttaccacta aggggttaca tggctactca gaatgaaaga 1680 taaattgcca ggcctgttgc aatcgtcttt tttttgagat gggagtcttg ctctgtcgcc 1740 caggctggag tgcagaggtg cgatctcagc tcactgcaac ctccacctcc cgggtcaagc 1800 aattctcctg cctcagcttc ccgagtagct ggaattacag gtgcccacca ccatgcctgg 1860 ctaatttttg tatttttagt agagacgggg tttcaccatg ttggccaggc tggtcttgaa 1920 cacctgacct caaatgatcc gcccacctcg gcctcccaaa gtgttgggat tacaggcgtg 1980 agccacctca ccaggccccg ttgcaatctt actccacttc gtttttcaca ggcagtcccg 2040 ggacatgccc attattaggg cctatttgat aggatgatac tgaggctcag agtcgggggg 2100 gtcacaaggc caaagccaca ccgctagaag ggctcacgga tcccatgcca gctcccgtcc 2160 tcttgggtgg catcaagctt gtgtgatatg aggtcttatg gtctgctcat gacagcctta 2220 aaagcaataa acagatacca acttccagca actttcccaa ctcagcttgc aaaggcttgc 2280 gggggggtcc ctgccctcga gcccataagg tgagcagctt agcccagtgc cgggcccant 2340 gtggagaagg cctgaattgc cctgtgaagc tgggggttgc caggcaggga atattcatgg 2400 aagcccctga ccatgtactc acactgctct tcctcagttc aggggttctt ggatttgctc 2460 aaagttcaac ccaaaatatc ccttttacga ttctcagggg tcccaaccct tccagatcca 2520 atccccttaa ctttacataa gagttcccac aaggctgtga cttcaaactg tgttgtaaac 2580 tgcaacctgc agaatcaaat ttagggttat gttttcagtt gttatcagtc ttacggctat 2640 caagatatta aagagattct tttctggtta tcaaagaaaa aaa 2683 <210> 77 <211> 3328 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1190057.1:2000MAY01 <400> 77 ctgcggtggc ggcagcggtg ggagatgccg gggcggccgg cggcaggtcc atgtggcgct 60 cttaggtggg atgccagcgt cctgaaggcg gaggccctgg ccctccgtcc cctgcggcct 120 gggcatggca ttctcccagt cccacgtgat ggccgctcgg cggcaccagc acagccggct 180 catcatcgag gtggacgagt acagctccaa ccccacccag gccttcacct tctacaacat 240 caaccagggc cgcttccagc caccgcatgt gcagatggtg gacccggtgc ctcacgatgc 300 ccccaaacct ccaggctaca cccgcttcgt ctgcgtctct gatacccact cgaggacgga 360 ccccatccag atgccgtacg gcgacgtgct gatccacgct ggggacttca ctgagctggg 420 gctcccgagc gaggtgaaga agttcaacga gtggctgggc agcctgccct acgagtacaa 480 gatcgtgatc gcaggcaacc acgagctgac ctttgaccag gagttcatgg ccgacctcat 540 caagcaggac ttttactact tcccatctgt gtcgaagctg aagccggaga actatgagaa 600 tgtgcagtcg ctgctgacca actgcatcta ccttcaggac tcggaggtca ccgtgcgggg 660 cttccggatc tatggctccc catggcagcc ctggttctac ggctggggct tcaacctccc 720 gcgaggccaa gccctgctgg agaaatggaa cctcattccc gaaggcgtag acatcctgat 780 aacccatgga ccaccactgg gcttcctgga ctgggtcccc aagaagatgc agcgggtggg 840 ctgtgtggag ctgctcaaca cggtgcagag gcgcgtccag ccgcggttac atgtctttgg 900 ccacatccac gaagggtatg gtgtcatggc agatgggacg accacctatg tgaatgcgtc 960 cgtatgcact gtgaactacc agcccgtgaa cccgcccata gtcatcgacc tccccacacc 1020 ccggaactcc tgactgctcc ccactgcccc tgaccatgca cgcccgtgtc agctccacag 1080 gcctgggccc ggccaactgt tcccttccat gctgagttgc ctgggacgac ccatctggct 1140 gcggggactg ggcctagcag gcaggtcagg gccttggaac gactctttag ccttctgtca 1200 cctggagttg ggaccctgcg catccccatc aggggttctg tgctcattta cgtgtttctg 1260 cgtgtacatc ctgcgtgtac ctcgtttaaa ggacctacta agctcatggc cctgtcatgt 1320 ttgggaaatg actaagatct tcattcttct cccttggacg ccctccctgg ttagggaagc 1380 tgctgcatct tgaatgggtt tcggaagtta cacaaaatct ccctctaacc acgggtctgt 1440 gtggcggcat gcccctggga ttggggtggg tgggaggatt tcgtgagctg caacacagac 1500 agtccctttc gtgcccctcc caagtgaggg aggagacagg cccaaaggcg gaggccctcc 1560 gagggagcat ttagggacat ctcaggaatt cagaccgcac ctggccaggc ccacagctgt 1620 tttgcctggc attgttcccc cctttttctt cccataggca cttttgttta cttgaacaat 1680 gacctgagtg tcctaggcat tcactcggag cctgggatga tgggggcatg gttctacaga 1740 atgagccact ggcattcgtg cccaggacca gtgagagcgt tcccagtcat ggggggatga 1800 cccttggtcc ccacggggaa cacactgctc tgtagaatgc ggtacgcctg gatggaaggg 1860 tctgcaggct taggctgcag caggcctgcc atggcgtgtg aacccatgtg ccagtgcacg 1920 caccgacaca catgcactgc acgcagccgg tcttaattga accaagtggg tcctgtgttt 1980 ctcttttctg ccccgtagtg aggttctgtt ccttaggtgc gggcttaccc ttgcaccggt 2040 tagggattcg tgtcttggca tgcgctgcag cctgagtgaa gcccatggac catgccggcc 2100 cctgtgaatt tggagggtgg ccacagggac ccgagcgggc ccccaggctc ccagcagccc 2160 cacctttgga cagccttctt tttccttctt tgaattagga ctggaggggg tggggccagg 2220 gcggtggtgg gaaccggtag gcccttagat gagggggcag ccagtcaggc atgaatatgg 2280 ggcaagttca gggctcagat tctggtcggt tatttaatat tttggttcat catggacttt 2340 ttctgcattt attttgattt ttaacgttgc attaaagtag taattatttg tcctgaattg 2400 gtgacttttt tttgcacccc tttccgttgt acatctgaga gaagggtgtc actccctcac 2460 ccaggtccca gccctgggaa ccagcctacc gtgagccctt ttgcagatat agactcattt 2520 catcctcaga tggtccttca aggtaggtac tttagtccca ttttagagat gagacgattg 2580 aggccagagg ggtgtggtaa cttgcctggg ggctcacagc acaaaaggag ccgaggcagg 2640 atctgaccct tgttctctgg cgctgactgc cctcactttg ccatgacccg aagttatgtc 2700 cctacaaagc aatgcatggt ccaaggctct ttttattgta tttttatttt taagggtcct 2760 gttcaaaact ggtgtgagct ctgaggagtc cttgaaccct gggtgcagca tccctagcat 2820 cctgggagtc cttttctgcc cacactgagc tgggctcctc gaggggtggg gctgctgtcc 2880 ctggaagcct ggcagcagca ctgtatcggg ttggctgaag ctgagcgccg tggggtgcag 2940 ggctccagga atcccgtttg gctgaagggg ttccctgtag cccgggatgt ttatgaggtc 3000 ctctctgatg ccccaggcgc aggacatgtg tgcgggtgga gaaaagcagg ccctttcagt 3060 gccagctcca ctcaatttct atgtggacca agaacgataa acttaaaaaa tttttttttc 3120 ctaaggtatc ttcagaatat ggtgtatttt tatgtggaaa agaaaagtta tgaaggcagc 3180 tgttacttta agagaaaatt cattagtagt aaaacgaggt atgaagatga cggcgtgctt 3240 ctcaatcatt ttggcataac ttgattgtgg ctgtaattca cacccttttt tggtcaacca 3300 tgtcagacaa taaactcttt gtaaaaag 3328 <210> 78 <211> 2792 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:221836.3:2000MAY01 <220>
<221> unsure <222> 2088, 2091, 2093, 2095, 2097, 2099, 2101, 2103, 2105, 2107, 2109, 2113, 2115, 2117, 2119, 2123, 2125, 2129, 2131 <223> a, t, c, g, or other <400> 78 catgaagcca cgcatgaaaa tttttctgcg tcaaaagaag gtgactaccc agatgattgc 60 caagagcctg gccaatgtag aatatgatac atataaacct accttcacaa ataagcaggt 120 gagaatcacc tttgggttct cttgcaagag tagtaaccag tttggaataa tgatgtatca 180 taacaaccga ctcataaaat cttttgagaa ggtgtgggtg ccgggtgaag ccaactcgtg 240 tgagaaagtg atggcgagta attggagtca ttgagtgcaa tttcctaaaa cctgcctaca 300 acaaacaaga ctttgagtat accaagggag taccggctaa caataaatgc ccttgcccag 3&0 aagctcaatg cttactggaa gaaaaaaaca tctcaagata attttgagac ctcaactgta 420 gccaggccaa taccgaaggt tcctgaccag acatgggttc agtgtgatga gtgtcttaaa 480 tggagaaagc ttcctgggaa gattgatcca tccatgttac ctgcaagatg gttttgttat 540 tataattccc atccaaagta ccaggagatg ctctgttcca gaggaaccag aaatcactga 600 tgaagacctg tgcttgagca aagctaagaa acaagaacca actgttgagg agaagaagaa 660 gatgcctatg gaaaatgaga accaccaggt attcagtaat ccaccaaaga tccttactgt 720 tcaagaaatg gctggattga ataacaagac aacttggata tgagggaatt catagcccta 780 gtgtgcttcc ttctggtgga gaagaaagca gatcaccatc tcttcaactt aagcctctgg 840 attccagtgt tttacagttt tccagtaagt acaaatggat cctaggtgaa gaaccggtgg 900 agaaacgaag aaggctccag aaatgagatg acaacacctt ctctagatta ttccatgcct 960 gctccttaca ggagggtaga agcacctgtt gcctacccag aaggggagaa cagccatgat 1020 aaatcgagtt ctgagagaag tacaccacca taccttttcc cagaataccc agaagcaagc 1080 aagaatacag gtcagaatag ggaggtttca attctgtatc caggggccaa agaccaacgc 1140 caggggtccc tgcttcctga agaattagaa gatcagatgc caagattggt ggcagaagaa 1200 tctaacagag gtagcacaac cataaacaaa gaagaagtca acaagggacc ttttgtagct 1260 gttgtgggtg ttgccaaagg tgttagagat tcaggagctc ctattcagct tgatcccttg 1320 taacagagag gagcttgctg agagacgaaa agcagttgaa tcctggaacc cagtgcctta 1380 ttctgtggcc tctgctgcaa tccctgctgc agccattggg gagaaagcaa gaggctatga 1440 ggagagcgaa ggtcataata caccaaagtt gaagaaccag agagagctgg aagaattgaa 1500 gagaaccaca gaaaaattgg aacgtgtttt ggctgaaagg aatttgttcc agcaaaaggt 1560 ggaggagctg gaacaggaga ggaatcactg gcagtctgaa ttcaagaaag tccaacatga 1620 attggtgatc tacagtaccc aggaggcgga aggcttgtac tggagcaaga aacacagtgg 1680 attatcgcca agctgaattc ccagatatct gaaagactga gctggaaaga agccaacaga 1740 ggaaaacgca cgagttaaaa gagaaactga aggaaacaga gacacaccct ggaaatgctg 1800 ccacgaaggc tcacggtctc cctacccgga cccccagagg gagatgacct agaaagggct 1860 ttggcacaag cttacgcgcg ctacgtatac cacgtcagca tatctccctt acttctgtcc 1920 tccctcactt ggagcttcgt gagatcgggt atgactcaga aacaagtgga tgggatccct 1980 gtacacggtg ctgggaggca aaatccccat actggattga ggcaccagac tgtataccct 2040 tctcttctct tataattctg tctgttctct tttctctccc tccctcangt ntntntntnt 2100 ntntntntnt ctntntntnt ctntntctna ncctcaccta tatgccttat atagagaatc 2160 tctgtgtaaa tccgtggctc ataatcagtc tcctttttat cagtttttgg gtgtggagaa 2220 agaggccagt tttaaatagg ctttcaagag gtctaggggt cagaaaagca atagtcactt 2280 aagctaggtg acctgaagag ctttaattct tcatgacctg tat,atgtgcg tctattgtat 2340 atctttcttc tgaaatggtg ttgtatatca ttgtagtgtt agatcaatca ggcagatagt 2400 tggtgtccgg tataccaggt attattgggg ggtaagctta acaagtacaa ctcatgtttg 2460 caagccttcg aagtatgtaa caatcgtcgg tggaaatata agaccatata tcacattata 2520 cacaaaagtg tgtgatatgt acaagtgagt ggtacagata tgacatggga agatctgggg 2580 gaggaagttc aaggaaggca ccacaccaga aatggggacc taaattaagg cttaaagaat 2640 gaggcatggc cacactgtca gtgagtgttc tttaggtggt aggactatgg ttgatatttt 2700 ttcttcttcc tatcttcctg cctttttcag attttcaata ttaaacttgt tattcttaca 2760 ttggaaaaaa ataaattgtt tttaaaaaga tc 2792 <210> 79 <211> 918 <212> DNA
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte TD No: LT:334047.3:2000MAY01 <220>
<221> unsure <222> 380, 419 <223> a, t, c, g, or other <400> 79 tctttatgta tttttaaaaa aactaattta agttaaatgg cagtaaacca tgataattta 60 gaaaacatgg tgaaactgag agtgaagaga aatgttcttt acgtaaacca cactgtaaac 120 cataaaactt atttttgtca actgcttttc atgacagtgg ctgggaattt gacatttcta 180 ctacagtagg caaaaataca tgtaaaatac actctcccac ataccacatc acatctctat 240 ttgtatttcc aaactaaaag cattacagcc caaaaaagtg ctgcgtgcac tggtctagtt 300 acaccaagaa gtgtatgttc acaccagcaa caccttaagc tggtatctgt gtggcaaggc 360 cactgctggt ggcccctgan gccaagccct cttcaatgga tccagtttgg ctcaccaana 420 gaaatccact gctctttaac ccaaaaggtg gtaagctttt caatggcctc cagttaccac 480 aagataaaac aaacaaaatt ctcaaacaga ttatgaaacc caactgaagt atccacatga 540 cagcgttcaa tactacctcg ccacttcaaa atgtgtcagc agcaattagc tatgaaaatg 600 agtgttgtga aaattcgcaa tagtttgaaa ctgaatattt taaaactaga tatctttaat 660 atgacagtaa acaatgtgac agaaacatgg ctgtttctct catcttgtct gagatataca 720 ttccatacag gtgactgggt cccataagtt ttctaagaaa aacttttcct ttccacttaa 780 tgatcctaag aagtcagtgc aatctggttc ttctccctgc agaagggtta tttagtttgg 840 gatgtaacat tttacaacaa taatacaaac gtcctgggag aataccacaa taaatgtctc 900 aaaaaccact cagttaat 918 <210> 80 <211> 202 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Tncyte ID No: LG:223939.1.orf3:2000FEB18 <400> 80 Glu Ile Met Glu Leu Val Leu Val Lys Tyr Gln Gly Lys Asn Trp Asn Gly His Phe Arg Ile Arg Asp Thr Leu Pro Glu Phe Phe Pro Val Cys Phe Ser Ser Asp Ser Thr Glu Val Thr Thr Val Asp Leu Ser Val His Val Arg Arg Ile Gly Ser Arg Met Va1 Leu Ser Val Phe Ser Pro Tyr Trp Leu Ile Asn Lys Thr Thr Arg Val Leu Gln Tyr Arg Ser Glu Asp Ile His Val Lys His Pro Ala Asp Phe Arg Asp Ile Ile Leu Phe Ser Phe Lys Lys Lys Asn Ile Phe Thr Lys Asn Lys Val Gln Leu Lys Tle Ser Thr Ser A1a Trp Ser Ser Ser Phe Ser Leu Asp Thr Val Gly Ser Tyr Gly Cys Val Lys Cys Pro Ala Asn Asn Met Glu Tyr Leu Val Gly Val Ser Ile Lys Met Ser Ser Phe Asn Leu Ser Arg Ile Val Thr Leu Thr Pro Phe Cys Thr Ile Ala Asn Lys Ser Ser Leu Glu Leu Glu Val Gly Glu Ile Ala Ser Asp Gly Ser Met Pro Thr Asn Lys Trp Asn Tyr Ile Ala Ser Ser Glu Cys Leu Pro Phe Trp <210> 81 <211> 91 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:397140.1.orf1:2000FEB18 <400> 81 Pro Cys Ala Pro Ile Ser Leu Cys Ala Arg Asp His Met His Met Gly Glu Cys Leu Cys Ala His Asp Phe Met His Ile Gly Glu Tyr Leu Cys Ala His Glu His Met His Met Gly Glu Cys Leu Cys Ala His Glu Tyr Met His Thr Gly Glu Cys Leu Cys Ala His Glu Tyr Met His Met Gly Ile Cys Leu Cys Ala Arg Asp Tyr Met His Met Gly Glu Cys Leu Cys Ala Arg Asp Tyr Met His Val Gly Glu Cys Ser <210> 82 <211> 197 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1094205.1.orf3:2000FEB18 <400> 82 Pro Lys Met Ala Ala Pro Pro Gly Glu Tyr Phe Ser Val Gly Ser G1n Val Ser Cys Arg Thr Cys Gln Glu Gln Arg Leu Gln Gly Glu Val Val Ala Phe Asp Tyr Gln Ser Lys Met Leu Ala Leu Lys Cys Pro Ser Ser Ser Gly Lys Pro Asn His Ala Asp Ile Leu Leu Ile Asn Leu Gln Tyr Val Ser Glu Val Glu Ile Ile Asn Asp Arg Thr Glu Thr Pro Pro Pro Leu Ala Ser Leu Asn Val Ser Lys Leu Ala Ser Lys Ala Arg Thr Glu Lys Glu Glu Lys Leu Ser Gln Ala Tyr Ala Ile Ser Ala Gly Val Ser Leu Glu Gly Gln Gln Leu Phe Gln Thr Ile His Lys Thr Ile Lys Asp Cys_Lys Trp Gln Glu Lys Asn Ile Val Val Met Glu Glu Val Val Ile Thr Pro Pro Tyr G1n Val Glu Asn Cys Lys Gly Lys Glu Gly Ser Ala Leu Ser His Val Arg Lys Ile Val Glu Lys His Phe Arg Asp Val Glu Ser Gln Lys Ile Leu Gln Arg Ser Gln Ala Gln Gln Pro Gln Lys Glu Ala Ala Leu l85 190 195 Ser Ser <210> 83 <211> 98 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Tncyte ID No: LG:481361.5.orf3:2000FEB18 <400> 83 Pro Ser Gln Gln Cys Lys Val Trp Tyr Glu Ala Ala Thr His Ser Leu Leu Arg Asn Leu Ala Thr Thr Cys Glu Asn Tyr Asn Tyr Phe Leu G1n Ser Gln His Ile Phe Leu Ile His Ala Ser Thr His Arg Lys Met Pro Ile Asn Pro Gln Val Leu Met Ile Thr Pro Glu Val Ile Gly His Phe His Phe Ile Leu Cys Ile Phe His Cys Phe Pro Asp Phe Pro Leu Gly Thr Met Ser His Leu Tyr Asp Gln Arg Glu Arg Tyr Lys Leu Tyr Leu Arg Val <210> 84 <211> 121 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:981170.1.orf1:2000FEB18 <400> 84 Asp Asp Cys Met Leu Thr His Pro Leu Gln Gly Pro Gly Leu Asp Leu Gly Leu His Cys Ile Leu Ser Asn G1y Leu Ala Gly Ala Pro Phe Gly Leu Leu Ser Leu Phe Ser Pro Glu Leu Gly Trp Trp Glu Lys Arg Gly Trp Ser Glu Ser Ile Ser Ile Gln Tle Pro Ala Gly Ile Thr Leu Gly Val Phe Leu Ala Cys Phe Gly Leu Lys Leu Ser Tyr Ile Val Tyr Trp Leu Pro Lys Ser Gly Leu Lys Ser Glu Lys Met Gln Ala Met Asn Pro Ser Ala His Ser Ser Pro Thr Phe Pro Ala Leu Phe Tyr Leu Gly Gly Gln Trp Lys Gly G1y Glu Ala Met Pro <210> 85 <211> 136 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:197613.1.orf2:2000FEB01 <400> 85 Ala Ser Ser Gly His Ala Pro Leu Ala Ala Ser Thr Arg Lys Ala Pro Gln Ala Glu Cys Gly Met Ile Ser Ile Thr Glu Trp Gln Lys Ile Gly Val Gly Ile Thr Gly Phe Gly I1e Phe Phe I1e Leu Phe Gly Thr Leu Leu Tyr Phe Asp Ser Val Leu Leu Ala Phe Gly Asn Leu Leu Phe Leu Thr Gly Leu Ser Leu Ile Ile Gly Leu Arg Lys Thr Phe Trp Phe Phe Phe Gln Arg His Lys Leu Lys Gly Thr Ser Phe Leu Leu Gly Gly Val Val Ile Va1 Leu Leu Arg Trp Pro Leu Leu Gly Met Phe Leu Glu Thr Tyr Gly Phe Phe Ser Leu Phe Asn Cys Ser G1y Asp Phe Lys Ala Leu Ala Arg Trp Ser Glu Lys Gln Arg <210> 86 <211> 71 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:902682.1.orf3:2000FEB01 <400> 86 Thr Leu Ser Leu Ala Val Ser His Met Val Phe Gly Leu Leu Val His Arg Ser Gln Lys Ser Arg Phe Glu Asn Leu His Leu Asp Phe Gly Gly Cys Met Glu Met Pro Gly Tyr Pro Gly Arg Ile Leu Leu Glu Arg Gln Ser Pro Asn Arg Glu Pro Leu Leu Arg Gln Cys Arg Arg Glu Met Leu Gly Gln Asn Ser G1n Ala Glu 65 ~ 70 <210> 87 <211> 608 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:212029.1.orf2:2000FEB01 <220>
<221> unsure <222> 18, 388 <223> unknown or other <400> 87 Tyr Pro Ala Pro Gln Pro Val Arg Thr Asp Val Ala Val Leu Arg Tyr Gln Xaa Pro Pro Glu Tyr Gly Val Thr Ser Arg Pro Cys Gln Leu Pro Phe Pro Ser Thr Met Gln Gln His Ser Pro Met Ser Ser Gln Thr Ser Ser Ala Ser Gly Pro Leu His Ser Val Ser Leu Pro Leu Pro Leu Pro Met Ala Leu Gly Ala Pro Gln Pro Pro Pro Ala Ala Ser Pro Ser Gln Gln Leu Gly Pro Asp Ala Phe Ala Ile Val Glu Arg Ala Gln Gln Met Val G1u Ile Leu Thr Glu Glu Asn Arg Va1 Leu His Gln Glu Leu Gln Gly Tyr Tyr Asp Asn Ala Asp Lys 110 . 115 120 Leu His Lys Phe Glu Lys Glu Leu Gln Arg Ile Ser Glu Ala Tyr Glu Ser Leu Val Lys Ser Thr Thr Lys Arg Glu Ser Leu Asp Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Leu His Asp Phe Asn Arg Asp Leu Arg Asp Arg Leu Glu Thr Ala Asn Arg Gln Leu Ser Ser Arg Glu Tyr G1u G1y His Glu Asp Lys Ala Ala Glu Gly His Tyr Ala Ser Gln Asn Lys Glu Phe Leu Lys Glu Lys Glu Lys Leu Glu Met Glu Leu Ala Ala Val Arg Thr A1a Ser Glu Asp His Arg Arg His Ile Glu Ile Leu Asp Gln Ala Leu Ser Asn Ala Gln Ala Arg Val Ile Lys Leu Glu Glu Glu Leu Arg Glu Lys Gln Ala Tyr Val Glu Lys Val°Glu Lys Leu Gln Gln Ala Leu Thr Gln Leu Gln Ser Ala Cys Glu Lys Arg Glu Gln Met Glu Arg Arg Leu Arg Thr Trp Leu Glu Arg Glu Leu Asp Ala Leu Arg Thr Gln Gln Lys His Gly Asn Gly Gln Pro Ala Asn Met Pro Glu Tyr Asn Ala Pro A1a Leu Leu Glu Leu Val Arg Glu Lys Glu Glu Arg Tle Leu Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys Tyr Leu Glu Glu Ser Thr Ile Arg His Phe Ala Met Asn Ala Ala Ala Thr Ala Ala Ala Glu Arg Asp Thr Thr Ile Ile Asn His Ser Arg Asn Gly Ser Tyr Gly Glu Ser Ser Leu Glu Ala His Ile Trp Xaa Glu Glu Glu Glu Val Val Gln Ala Asn Arg Arg Cys Gln Asp Met Glu Tyr Thr Ile Lys Asn Leu His Al~. Lys Ile I1e Glu Lys Asp Ala Met Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Asp Ala Gly Lys Thr Asp Ser Ser Ser Leu Arg Pro Ala Arg Ser Val Pro Ser I1e Ala Ala Ala Thr Gly Thr His Ser Arg Gln Thr Ser Leu Thr Ser Ser G1n Leu Ala Glu Glu Lys Lys Glu Glu Lys Thr Trp Lys Gly Ser Ile Gly Leu Leu Leu Gly Lys Glu His His Glu His Ala Ser Ala Pro Leu Leu Leu Pro Pro Pro Thr Ser Ala Leu Ser Ser Ile Ala Ser Thr Thr Ala Ala Ser Ser Ala His Ala Lys Thr G1y Ser Lys Asp Ser Ser Thr Gln Thr Asp Lys Ser Ala Glu Leu Phe Trp Pro Ser Met A1a Ser Leu Pro Ser Arg Gly Arg Leu Ser Thr Thr Pro Ala His Ser Pro Val Leu Lys His Pro Ala Ala Lys Gly Thr Ala Glu Lys Leu Glu Asn Ser Pro Gly His Gly Lys Ser Pro Asp His Arg Gly Arg Val Ser Ser Leu Leu His Lys Pro Glu Phe Pro Asp Gly Glu Met Met Glu Va1 Leu Ile <210> 88 <212> 396 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:249170.1.orf1:2000FEB01 <400> 88 Ser Ala Cys Ala Gly His Ser Leu Ser Pro Ala Ala Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg Val His Glu Val Ala Glu Phe Trp Cys His Thr Ile His Thr Gly Va1 Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala Gln Gly Lys Asp Pro Thr Glu Trp His Val His Thr Cys Gly Leu Ala Asn Met Phe Ala Tyr His Thr Leu Gly Tyr Glu Asp Leu Asp Glu Leu Gln Lys Glu Pro Gln Pro Leu Val Phe Val Ile Glu Leu Leu Gln Val Asp Ala Pro Ser Asp Tyr G1n Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met Lys Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly Arg Tyr Glu Glu A1a Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp Leu Lys Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr Cys Gln Cys Leu Leu Lys Lys Glu Glu Tyr Tyr Glu Val Leu Glu His Thr Ser Asp Ile Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr Va1 Arg A1a Arg Ala His Ala Glu Val Trp Asn Glu A1a G1u Ala Lys Ala Asp Leu G1n Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg Glu Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu Arg Leu Arg Cys Arg Asn Met Leu Ser Gln G1y Ala Thr Gln Pro Pro Ala G1u Pro Pro Thr Glu Pro Pro Ala G1n Ser Ser Thr Glu Pro Pro Ala Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala Gly Pro Pro Ala Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His Ser Leu Gln His <210> 89 <211> 109 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:813218.1.orf1:2000FEB01 <220>
<221> unsure <222> 4, 7, 13 <223> unknown or other <400> 89 Gly Cys Glu Xaa Ile Gly Xaa Phe Met His Tyr Trp Xaa Glu Ser Glu Met Va1 Gln Ser Leu Trp Glu Ser Leu Ala Val Leu G1n Met Val Lys Arg Arg Ala Thr Ile Trp Pro Ser Asn Ser Pro Tyr Arg His Met Pro Lys Ile Ile Glu Asn Ile Cys Ser Gly Leu Pro Ser Leu Gly Pro Leu Pro Leu Tyr Gly Ser Ser Val Phe Thr Leu Leu Ser Leu Ala Ser Ala Leu Phe Trp Ser Met Phe Val Lys Ala Arg Ala Glu Leu Leu Leu Ala Val His His Cys Cys Leu Pro Pro Ser Gln Thr Arg Cys <210> 90 <211> 94 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:902522.3.orf2:2000FEB01 <400> 90 Trp Ser Glu Phe Val Ala Ala Phe Leu Ser Leu Val Ala Leu Leu Arg Arg Arg Arg Asn Glu Ala Glu Ala Glu Arg Val Lys Thr Lys Thr Ala Ala Lys Tyr Gly Leu Ser Ala Gln Pro Arg Leu Va1 Asp Ile Ile Ala Ala Val Pro Pro Gln Tyr Arg Lys Val Leu Met Pro Lys Leu Lys Ala Lys Pro Ile Arg Thr Ala Ser Gly Tle Ala Val Val A1a Val Met Cys Lys Pro His Arg Cys Pro His Ile Ser Phe Thr Gly Asn Ile <210> 91 <211> 211 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:474304.1.orf2:2000FEB01 <400> 91 Glu Pro Ser Leu Ala Thr Tyr His His Ile Ile Arg Leu Phe Asp Gln Pro Gly Asp Pro Leu Lys Arg Ser Ser Phe Ile Ile Tyr Asp Ile Met Asn Glu Leu Met Gly Lys Arg Phe Ser Pro Lys Asp Pro Asp Asp Asp Lys Phe Phe Gln Ser Ala Met Ser I1e Cys Ser Ser Leu Arg Asp Leu G1u Leu Ala Tyr Gln Val His Gly Leu Leu Lys Thr Gly Asp Asn Trp Lys Phe Ile Gly Pro Asp Gln His Arg Asn Leu Tyr Tyr Ser Lys Phe Phe Asp Leu Ile Cys Leu Met Glu Gln Gly His Ser Leu Gln His <210>

21e Asp Val Thr Leu Lys Trp Tyr Glu Asp Leu Ile Pro Ser Ala Tyr Phe Pro His Ser Gln Thr Met Ile His Leu Leu Gln A1a Leu Asp Val A1a Asn Arg Leu Glu Val Ile Pro Lys Ile Trp Lys Gly Gln Phe Tyr Phe Leu Cys Val Arg Val His Leu Thr Ser Ile Ser Ser Thr Leu Tle Met Asn Val Leu Thr Leu Leu Leu Gly Met Lys Thr Ser Ile Leu Thr Glu Pro Asn Val Leu Val Glu Met Tyr Phe Lys Val Met Cys Ser Cys Cys Met Leu Ala Ile Arg Arg Lys Phe Cys <210> 92 <211> 290 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:027320.1.orf3:2000FEB01 <400> 92 Ser Asp Gly Gly Ser Asp Ala Asp Phe G1y Gly Gly Ser Gly Glu Pro Asp Ser Asp Arg Gly Gly Glu Arg Glu Leu Arg Leu Arg Arg Gly Glu Leu Gly Gly. Arg Leu Leu Pro Arg Ala Ala G1u Glu Glu Met Ala Gly Pro Asn Gln Leu Cys Ile Arg Arg Trp Thr Thr Lys His Val Ala Val Trp Leu Lys Asp Glu Gly Phe Phe Glu Tyr Val Asp Ile Leu Cys Asn Lys His Arg Leu Asp Gly Ile Thr Leu Leu Thr Leu Thr Glu Tyr Asp Leu Arg Ser Pro Pro Leu G1u Ile Lys Val Leu Gly Asp T1e Lys Arg Leu Met Leu Ser Val Arg Lys Leu Gln Lys Ile His Ile Asp Val Leu Glu Glu Met Gly Tyr Asn Ser Asp Ser Pro Met Gly Ser Met Thr Pro Phe Ile Ser Ala Leu Gln Ser Thr Asp Trp Leu Cys Asn Gly Glu Leu Ser His Asp Cys Asp Gly Pro Ile Thr Asp Leu Asn Ser Asp Gln Tyr Gln Tyr Met Asn Gly Lys Asn Lys His Ser Val Arg Arg Leu Asp Pro Glu Tyr Trp Lys Thr Ile Leu Ser Cys Ile Tyr Val Phe Ile Val Phe Gly Phe Thr Ser Phe Ile Met Val Ile Val His Glu Arg Val Pro Asp Met Gln Thr Tyr Pro Pro Leu Pro Asp Ile Phe Leu Asp Ser Val Pro Arg Ile Pro Trp Ala Phe Ala Met Thr Glu Val Cys Gly Met Ile Leu Cys Tyr Ile Trp Leu Leu Val Leu Leu Leu His Lys His Arg Tyr Met Ala Val Tyr Gly Arg Asn Tyr Ile Glu Pro Leu Pro Phe Gly Val Ala Leu Val <210> 93 <211> 125 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:228319.1.orf2:2000FEB01 <400> 93 Glu Gln Ala Glu Glu Glu Lys Lys Pro Lys Asp Ser Thr Thr Pro Phe G1u Ser Arg Leu Ser Gln Ser Arg Lys Phe Ser Trp Thr Glu Tyr Leu Glu Ala Thr Gln Thr Asn Ala Val Pro Ala Lys Val Phe Lys Met Arg Leu Pro His Gly Phe Leu Pro Asn Met Lys Leu Glu Val Val Asp Lys Arg Asn Pro Arg Leu Ile Arg Val Ala Thr Ile Val Asp Val Asp Asp G1n Arg Val Lys Val His Phe Asp Gly Trp Asp His Lys Tyr Asp Tyr Trp Val Glu Ala Asp Ser Pro Asp Ile His Pro Ile Gly Leu Cys Asp Val Thr Gly His Pro Leu Glu Va1 Pro Lys Arg Thr Lys <210> 94 <211> 162 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:197267.2.orf2:2000MAY19 <400> 94 Ala Arg Glu Ala Ala Leu Pro Ala Ala Met Arg Glu Gly Gln Glu Met Gly Pro Thr Pro Val Pro Ser Asn Pro Leu Leu His Arg Ser Phe Pro Cys Trp Pro Arg Gly Trp Ser His Pro Val Pro Ser Asn 35 ~ 40 45 Pro Leu Leu His Arg Ser Phe Pro Cys Trp Pro Arg Gly Trp Ser His Pro Val Pro Thr Arg Glu Leu Leu Leu Glu Pro Ala Gln Pro Ala Asp Leu Leu Pro Pro Ala Pro Thr Ala Gly Pro Cys Ser Leu Ala Ser Trp Met Leu Ser Gln Pro Gly Arg Gly Ser Gln Val Lys Thr Gly Gly Thr Pro Thr Ala Thr Ala Gln Asp Ala Glu Ala Pro Leu Pro Asp Cys Asp Leu Cys Leu Ser Pro Ala Pro Val Gly Thr Trp Gln Pro Arg Ala Lys Ala Gly Trp Ala Gly Asp Pro Arg Asn Leu Ser Gly Asn Thr Phe Ser Pro Gly Trp Glu Gln <210> 95 <211> 181 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:403332.1.orf2:2000MAY19 <220>
<221> unsure <222> 28 <223> unknown or other <400> 95 Gly Gly G1u Thr Met Ser Lys Leu Ser Phe Arg Ala Arg Ala Leu Asp Ala Ala Lys Pro Leu Pro Ile Tyr Arg Gly Lys Xaa Met Pro Asp Leu Asn Asp Cys Val Ser Ile Asn Arg Ala Val Pro Gln Met Pro Thr Gly Met Glu Lys Glu Glu Glu Ser Glu His His Leu Gln Arg Ala I1e Ser Ala Gln Gln Val Phe Arg Glu Lys Lys Glu Ser Met Val Ile Pro Val Pro Glu A1a Glu Ser Asn Val Asn Tyr Tyr Asn Arg Leu Tyr Lys Gly Glu Phe Lys Gln Pro Lys Gln Phe Ile His Ile Gln Arg Ile Trp G1y His Tyr Gln Pro Glu Thr Thr Leu Lys Phe Leu Leu Val Cys Phe Val His Leu Phe Leu Asp His Ser Ile Ser Phe Asn Leu Gly Cys Arg Ser Ala Gln Gly Ser Val Leu Arg Lys Ile Phe Cys Phe Ser Phe Leu Pro Lys Gly Lys Leu Arg Asn Thr Lys Phe Phe Ala Phe Pro Phe Cys Met Ala Asn Leu Phe Leu <210> 96 <211> 198 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:983076.3.orf3:2000MAY19 <400> 96 Trp Asn Leu Met Ser Ile Pro Leu Phe Ser Phe Leu Cys Tyr Gln Arg Asp Leu Glu Pro Tyr Gly Tyr Tyr Leu Glu Asn Glu His Ser Tyr Ile Tyr Asn Ile Trp Lys Tyr Leu Glu Ser Asn His Glu Tyr Ser Phe Cys Phe Thr Ser Ile Leu Leu Asn Cys Leu Phe Ile Phe Cys His His Asn Asn Trp His Pro Val Leu Ala Val Met Ile Val Pro Asn Ser Cys Val Val Tyr Ala Pro Gly Leu Pro Leu Leu His Gly Leu Ser Ser Phe Pro Trp Gln Ile Ala Ala Leu Leu Glu Phe Ile Ser Lys Glu Asn Ala Ile Met Thr Arg Ile Leu Gln G1n Val Ser Gln Phe Val Ile Leu Ser Val Thr Arg Arg Arg Lys Ile Thr Leu Thr Lys Gln Val Leu Ile His Cys Tyr Leu Leu Leu Arg Ile 65!104 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Inc Lys Lys Gly Trp Gly Ile Leu Glu Pro Lys Ile Asp Tyr Phe Lys Pro Glu Glu His Val Phe Ile Leu Val Ser Val Cys Ser Val Leu Ser Gly Cys Tyr Cys Phe Ser Ile Leu Pro Ala Arg Arg Cys Leu Gly Arg Ala <210> 97 <211> 349 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:216612.3.orf3:2000MAY19 <400> 97 Gly Thr Gly Pro His Gly Ser Ala Pro Arg Pro Pro Pro Val Cys Cys Ala Arg Gly Gly Leu Arg Ser Pro Gly Arg Arg Arg Ala Pro G1y Ala Gly Gly Glu Met Gly Arg Tyr Ser Gly Lys Thr Cys Arg Leu Leu Phe Met Leu Val Leu Thr Val Ala Phe Phe Val Ala Glu Leu Val Ser G1y Tyr Leu Gly Asn Ser I1e A1a Leu Leu Ser Asp Ser Phe Asn Met Leu Ser Asp Leu Ile Ser Leu Cys Va1 Gly Leu Ser Ala Gly Tyr Ile Ala Arg Arg Pro Thr Arg Gly Phe Ser Ala Thr Tyr Gly Tyr Ala Arg Ala G1u Val Val Gly A1a Leu Ser Asn A1a Val Phe Leu Thr A1a Leu Cys Phe Thr Ile Phe Val Glu Ala Val Leu Arg Leu Ala Arg Pro Glu Arg Ile Asp Asp Pro Glu Leu Val Leu Ile Val Gly Val Leu Gly Leu Leu Val Asn Val Val Gly Leu Leu Ile Phe Gln Asp Cys Ala Ala Trp Phe A1a Cys Cys Leu Arg Gly Arg Ser Arg Arg Leu Gln Gln Arg Gln G1n Leu Ser G1u Gly Cys Val Pro Gly Ala Phe G1y Gly Pro Gln Gly Ala Glu Asp Pro Arg Arg Ala Ala Asp Pro Thr Ala Pro Gly Ser Asp Ser Ala Val Thr Leu Arg Gly Thr Ser Val Glu Arg Lys Arg Glu Lys Gly Ala Thr Val Phe Ala Asn Val Ala Gly Asp Ser Phe Asn Thr Gln Asn Glu Pro Glu Asp Met Met Lys Lys Glu Lys Lys Ser Glu Ala Leu Asn Ile Arg Gly Val Leu Leu His Val Met Gly Asp Ala Leu Gly Ser Val Va1 Va1 Val Ile Ile Ile Leu Ser Ser Ala Phe Pro Leu Ile Lys Glu Thr Ala Ala Ile Leu Leu Gln Met Val Pro Lys Gly Val Asn Met Glu Glu Leu Met Ser Lys Leu Ser Ala Val Pro G1y Ile Ser Ser Val His Glu Val His Ile Trp Glu Leu Val Ser Gly Lys Ile Ile <210> 98 <211> 85 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:322465.1.orf3:2000MAY19 <400> 98 Tyr Cys Leu Lys Met Thr Glu Glu Thr Tle Ala Ser Ser Thr Glu Val Tle Leu Thr Ser Gln Met Ser Ser Glu Gly Trp Gln Arg Trp 20 25 ' 30 Gly Lys Ile Lys Ser Asp Gly Gly Gly Asn Ser Gly Val Pro Leu Gly Trp Ile Glu Gly Phe Ile Asn Val Cys Asp Gly Ile Met Asn His Asn Ser Glu Ala Phe Pro Pro Leu A1a Phe Phe Trp Phe Leu Phe Phe Leu G1u Ser Gly Ser Gln Lys Lys <210> 99 <211> 81 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:093477.1.orf2:2000MAY19 <400> 99 Val Ala Arg Thr Thr Gly Ala His His His Ala Trp Leu Ser Phe Val Phe Leu Val Glu Met G1y Gly Phe His His Val Gly Gln Thr Gly Leu Glu Leu Leu Thr Ser Ser Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Ile Gly Val Ser His Pro Thr G1n Pro Thr Thr Asn Ile Asn Ala Val Leu Met Met Tyr Gln Thr His Lys His Thr Tyr Leu Thr Arg Ser <210> 100 <211> 433 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:222880.1.orf2:2000MAY19 <400> 100 Pro Pro Arg Arg Pro Cys Pro Arg Ala Pro His Pro Ser Ala Leu Pro Ala Gly Pro Arg Asp Arg Ala Cys Thr Cys Ser G1y Leu Ser Ala Ser Pro Leu Arg Thr Ser Ser Trp Ser Ser Arg His Ser Ser Thr Arg Ser Arg Leu Gly Arg Gly Pro Gly Gly Gly Gly Arg Arg Ser Arg Gly Asp Ala Ser A1a Glu Arg Arg Glu Gly A1a Gly Pro Gly Arg Gln Ala Ala Ala Ser Ala Met Asn Pro Arg Gly Leu Phe Gln Asp Phe Asn Pro Ser Lys Phe Leu Tle Tyr Thr Cys Leu Leu Leu Phe Ser Val Leu Leu Pro Leu Arg Leu Asp Gly Ile Ile Gln Trp Ser Tyr Trp Ala Val Phe Ala Pro Ile Trp Leu Trp Lys Leu Leu Val Val Ala Gly Ala Ser Val Gly Ala Gly Val Trp Ala Arg Asn Pro Arg Tyr Arg Thr Glu Gly Glu Ala Cys Val Glu Phe Lys Ala Leu Leu Ile Ala Val Gly Ile His Leu Leu Leu Leu Met Phe Glu Va1 Leu Val Cys Asp Arg Val Glu Arg Gly Thr His Phe Trp Leu Leu Val Phe Met Pro Leu Phe Phe Val Ser Pro Val Ser Val Ala Ala Cys Val Trp Gly Phe Arg His Asp Arg Ser Leu G1u Leu Glu Ile Leu Cys Ser Val Asn Ile Leu Gln Phe Ile Phe Ile Ala Leu Lys Leu Asp Arg I1e Ile His Trp Pro Trp Leu Val Val Phe Val Pro Leu Trp Ile Leu Met Ser Phe Leu Cys Leu Val Val Leu Tyr Tyr Ile Val Trp Ser Leu Leu Phe Leu Arg Ser Leu Asp Val Val Ala Glu Gln Arg Arg Thr His Val Thr Met Ala Ile Ser Trp Ile Thr Tle Val Val Pro Leu Leu Thr Phe Glu Val Leu Leu Va1 His Arg Leu Asp Gly His Asn Thr Phe Ser Tyr Val Ser I1e Phe Val Pro Leu Trp Leu Ser Leu Leu Thr Leu Met Ala Thr Thr Phe Arg Arg Lys Gly Gly Asn His Trp Trp Phe Gly Ile Arg Arg Asp Phe Cys Gln Phe Leu Leu Glu Ile Phe Pro Phe Leu Arg Glu Tyr Gly Asn Ile Ser Tyr Asp Leu His His Glu Asp Ser Glu Asp Ala Glu Glu Thr Ser Val Pro Glu Ala Pro Lys Ile Ala Pro Ile Phe Gly Lys Lys Ala Arg Val Val Ile Thr Gln Ser Pro Gly Lys Tyr Val Pro Pro Pro Pro Lys Leu Asn Ile Asp Met Pro Asp <210> 101 <211> 419 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:898320.3.orf3:2000MAY19 <400> 101 Glu Val Trp Asp Cys Pro Gly Asn Ser Arg Val Ser Gly Pro Arg Pro Ile Leu Gly Ala Met Gly Val Ile Gly Ile Gln Leu Val Val Thr Met Val Met Ala Ser Val Met Gln Lys Ile Ile Pro His Tyr Ser Leu Ala Arg Trp Leu Leu Cys Asn Gly Ser Leu Arg Trp Tyr Gln His Pro Thr Glu Glu Glu Leu Arg Ile Leu Ala Gly Lys Gln Gln Lys Gly Lys Thr Lys Lys Asp Arg Lys Tyr Asn Gly His Ile Glu Ser Lys Pro Leu Thr Ile Pro Lys Asp I1e Asp Leu His Leu Glu Thr Lys Ser Val Thr Glu Val Asp Thr Leu Ala Leu His Tyr Phe Pro Glu Tyr Gln Trp Leu Val Asp Phe Thr Val Ala Ala Thr Va1 Val Tyr Leu Val Thr Glu Val Tyr Tyr Asn Phe Met Lys Pro Thr Gln G1u Met Asn Ile Ser Leu Val Trp Cys Leu Leu Val Leu Ser Phe Ala Ile Lys Val Leu Phe Ser Leu Thr Thr His Tyr Phe Lys Val Glu Asp Gly Gly Glu Arg Ser Val Cys Val Thr Phe Gly Phe Phe Phe Phe Val Lys Ala Met Ala Val Leu Ile Val Thr Glu Asn Tyr Leu Glu Phe Gly Leu Glu Thr Gly Phe Thr Asn Phe Ser Asp Ser Ala Met Gln Phe Leu Glu Lys Gln Gly Leu Glu Ser Gln Ser Pro Val Ser Lys Leu Thr Phe Lys Phe Phe Leu Ala Ile Phe Cys Ser Phe Ile Gly Ala Phe Leu Thr Phe Pro G1y Leu Arg Leu Ala Gln Met His Leu Asp Ala Leu Asn Leu Ala Thr Glu Lys Ile Thr Gln Thr Leu Leu His Ile Asn Phe Leu Ala Pro Leu Phe Met Val Leu Leu Trp Val Lys Pro Ile Thr Lys Asp Tyr Ile Met Asn Pro Pro Leu Gly Lys Glu Ser I1e Pro Leu Met Thr Glu Ala Thr Phe Asp Thr Leu Arg Leu Trp Leu Ile Ile Leu Leu Cys Ala Leu Arg Leu Ala Met Met Arg Ser His Leu Gln Ala Tyr Leu Asn Leu Ala Gln Lys Cys Va1 Asp Gln Met Lys Lys Glu Ala Gly Arg Ile Ser Thr Val Glu Leu Gln Lys Met Val Ile Ile Pro Gly Val Phe I1e Gln Asn Leu Ser Leu Pro Tyr Gln Trp Ile Ile Val Tyr Cys Pro I1e Leu Phe Thr Leu Asn Tyr His Gln Leu Lys Gly Lys <210> 102 <211> 127 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:1327047.1.orf1:2000MAY19 <400> 102 Gly Pro Pro Val Thr Phe Gly Asp His Glu Gly Ile Ser Lys Ala Met Gly Asn Val Pro Pro Lys Ala Glu Thr Pro Leu Arg Cys I1e Leu Glu Asn Trp Asp Gln Leu Asp Ser His Met Leu Arg Asn Lys Arg Leu Ile Phe Phe Cys Ser Thr Thr Trp Pro Arg Tyr Pro Leu Gln Gly Gly Glu Thr Trp Pro Pro Glu Gly Ser Ile Asn Tyr Asn Thr Ser Leu Gln Leu His Leu Phe Cys Arg Lys Glu Gly Ile Arg Ser Glu Val Pro Tyr Va1 Gln Thr Phe Phe Ser Leu Arg Asp Asn Ser Gln Leu Cys Lys Lys Cys Asp Leu Cys Pro Thr Gly Ser Pro Arg Val Tyr Leu Pro Thr Leu <210> 103 <211> 312 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:235157.21.orf2:2000MAY19 <400> 103 Ser Thr Pro Glu G1y Ile Ala Leu Ala Tyr Gly Ser Leu Leu Leu Met Ala Leu Leu Pro Ile Phe Phe G1y Ala Leu Arg Ser Val Arg Cys Ala Arg Gly Lys Asn Ala Ser Asp Met Pro Glu Thr Ile Thr Ser Arg Asp Ala Ala Arg Phe Pro Ile Ile A1a Ser Cys Thr Leu Leu Gly Leu Tyr Leu Phe Phe Lys Ile Phe Ser Gln Glu Tyr Ile Asn Leu Leu Leu Ser Met Tyr Phe Phe Val Leu Gly Ile Leu A1a Leu Ser His Thr Ile Ser Pro Phe Met Asn Lys Phe Phe Pro Ala Ser Phe Pro Asn Arg Gln Tyr Gln Leu Leu Phe Thr Gln,Gly Ser Gly Glu Asn Lys Glu Glu I1e Ile Asn Tyr Glu Phe Asp Thr Lys Asp Leu Val Cys Leu Gly Leu Ser Ser Ile Val Gly Val Trp Tyr Leu Leu Arg Lys His Trp Ile A1a Asn Asn Leu Phe Gly Leu Ala Phe Ser Leu Asn Gly Val Glu Leu Leu His Leu Asn Asn Val Ser Thr Gly Cys Ile Leu Leu Gly Gly Leu Phe Ile Tyr Asp Val Phe Trp Val Phe Gly Thr Asn Val Met Val Thr Val Ala Lys Ser Phe Glu Ala Pro Ile Lys Leu Val Phe Pro Gln Asp Leu Leu Glu Lys Gly Leu Glu Ala Asn Asn Phe Ala Met Leu Gly Leu Gly Asp Va1 23 0 . 235 240 Val Ile Pro G1y Ile Phe Ile Ala Leu Leu Leu Arg Phe Asp Ile Ser Leu Lys Lys Asn Thr His Thr Tyr Phe Tyr Thr Ser Phe Ala Ala Tyr Ile Phe Gly Leu Gly Leu Thr Ile Phe Ile Met His Ile Phe Lys His Ala Gln Leu Arg Val Leu Gly Gly Asn Pro Ala Ser Tyr Pro Glu Ala His Pro Leu Pro His Asn Ile Arg <210> 104 <211> 477 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:085713.1.orf1:2000MAY19 <400> 104 Leu Glu Leu Phe Val Phe Ser Ala Phe Ser Met Arg Thr Tyr Val Cys His Ile Cys Ser Ile Ala Phe Thr Ser Leu Asp Met Phe Arg Ser His Met Gln Gly Ser Glu His Gln I1e Lys Glu Ser Ile Val Ile Asn Leu Val Lys Asn Ser Arg Lys Thr Gln Asp Ser Tyr Gln Asn Glu Cys Ala Asp Tyr Ile Asn Val Gln Lys Ala Arg Gly Leu Glu Ala Lys Thr Cys Phe Arg Lys Met Glu Glu Ser Ser Leu Glu Thr Arg Arg Tyr Arg Glu Val Val Asp Ser Arg Pro Arg His Arg Met Phe Glu Gln Arg Leu Pro Phe Glu Thr Phe Arg Thr Tyr Ala Ala Pro Tyr Asn Ile Ser Gln Ala Met G1u Lys G1n Leu Pro His Ser Lys Lys Thr Tyr Asp Ser Phe Gln Asp Glu Leu Glu Asp Tyr Ile Lys Val Gln Lys Ala Arg Gly Leu Asp Pro Lys Thr Cys Phe Arg Lys Met Arg Glu Asn Ser Val Asp Thr His Gly Tyr Arg Glu Met Va1 Asp Ser Gly Pro Arg Ser Arg Met Cys Glu Gln Arg Phe Ser His Glu Ala Ser Gln Thr Tyr Gln Arg Pro Tyr His Ile Ser Pro Val Glu Ser Gln Leu Pro Gln Trp Leu Pro Thr His Ser Lys Arg Thr Tyr Asp Ser Phe Gln Asp Glu Leu Glu Asp Tyr Ile Lys Val G1n Lys Ala Arg Gly Leu Glu Pro Lys Thr Cys Phe Arg Lys Ile Gly Asp Ser Ser Val Glu Thr His Arg Asn Arg Glu Met Val Asp Val Arg Pro Arg His Arg Met Leu Glu Gln Lys Leu~Pro Cys Glu Thr Phe Gln Thr Tyr Ser Gly Pro Tyr Ser Ile Ser Gln Val Val Glu Asn Gln Leu Pro His Cys Leu Pro Ala His Asp Ser Lys Gln Arg Leu Asp Ser Ile Ser Tyr Cys Gln Leu Thr Arg Asp Cys Phe Pro Glu Lys Pro Val Pro Leu Ser Leu Asn Gln Gln Glu Asn Asn Ser Gly Ser Tyr Ser Val Glu Ser Glu Val Tyr Lys His Leu Ser Ser Glu Asn Asn Thr Ala Asp His Gln Ala G1y His Lys Arg Lys His Gln Lys Arg Lys Arg His Leu Glu Glu Gly Lys Glu Arg Pro Glu Lys Glu Gln Ser Lys His Lys Arg Lys Lys Ser Tyr Glu Asp Thr Asp Leu Asp Lys Asp Lys Ser Ile Arg Gln Arg Lys Arg Glu Glu Asp Arg Val Lys Val Ser Ser Gly Lys Leu Lys His Arg Lys Lys Lys Lys Ser His Asp Val Pro Ser Glu Lys Glu Glu Arg Lys His Arg Lys Glu Lys Lys Lys Ser Val Glu Glu Arg Thr Glu Glu Glu Met Leu Trp Asp Glu Ser I1e Leu Gly Phe <210> 105 <211> 105 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:482421.1.orf3:2000MAY19 <400> 105 Arg Glu Asn Tle Cys Ser Gly Leu Ser Pro Arg Pro Pro Ser Leu His Asn Phe Ser Ser Tyr Lys Leu Leu Leu Ala Phe I1e Asn Asn Ser Phe Leu Leu Glu Gly Leu Ile Arg Ile Phe Lys Glu Glu Glu Asn Asp Ser Val Ile Lys Gly Gly Met Glu Thr Val Glu Gly Ile Phe Phe Lys Ala Leu Leu Ile Ser Phe Lys Leu Asn Phe Ala Lys Ala Arg Asp Asn Ile Lys Glu Lys Leu Tyr Leu Lys Leu Val Ile Pro Asn Leu Ser Glu Leu Tyr Thr His Gln Arg Gln Tyr Ser Tyr <210> 106 <211> 213 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LG:330944.4.orf1:2000MAY19 <400> 106 G1n Glu Leu Asn Asn Ile Thr Lys Leu Asn Glu His Phe Ser Lys Phe Gly Thr I1e Val Asn Ile Gln Val Ala Phe Lys Gly Asp Pro Glu Ala Ala Leu Ile Gln Tyr Leu Thr Asn Glu Glu Ala Arg Lys Ala Ile Ser Ser Thr Glu Ala Va1 Leu Asn Asn Arg Phe Ile Arg Val Leu Trp His Arg Glu Asn Asn G1u Gln Pro Thr Leu Gln Ser Ser Ala Gln Leu Leu Leu Gln Gln Gln Gln Thr Leu Ser His Leu Ser Gln Gln His His His Leu Pro Gln His Leu His Gln G1n Gln Val Leu Val Ala Gln Ser Ala Pro Ser Thr Va1 His Gly Gly Ile Gln Lys Met Met Ser Lys Pro Gln Thr Ser Gly Ala Tyr Val Leu Asn Lys Val Pro Val Lys His Arg Leu Gly His Ala Gly Gly Asn Gln Ser Asp Ala Ser His Leu Leu Asn Gln Ser Gly Gly Ala Gly G1u Asp Cys Gln Ile Phe Ser Thr Pro Gly His Pro Lys Met Ile Tyr Ser Ser Ser Asn Leu Lys Thr Pro Ser Lys Leu Cys Ser Gly Ser Lys Ser His Asp Val Gln Glu Val Leu Lys Lys Lys Lys Gln Ser Gly Arg <210> 107 <211> 150 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:223060.1.orf3:2000MAY01 <400> 107 Lys Asn His G1n Tyr Phe Gly Ile Phe Ala Thr Pro Phe Ser Val Asp Ile Tyr Met Leu Pro Gly Asn Phe Glu Met Glu Cys Leu Glu Leu Gln Ser Asp Val Gln Leu Ile Glu Lys Phe Asp Phe Ala Ser Leu Leu Asp Phe Cys Lys Thr Cys Leu Pro Asn Asp Lys Tyr Pro Leu Leu His Asn His Thr Leu Phe Met Ser Leu Leu Leu Gly Ser Thr Tyr I1e Cys Glu Leu Leu Phe Ser Arg Met Lys Asn Thr Lys Ser Lys Ile Arg Thr Lys Ile Ser Asp Glu His Leu Glu Asn Ser Leu Arg Ile Ala Thr Thr Ser Ile Lys Pro Asp Thr Asp Gly Leu Arg Phe Ser Lys Thr Met Ser Ser Thr Pro Leu Val Leu Cys Cys 125 ° 130 135 Ser Leu Phe Phe Tyr Asn Lys Lys Tyr Gln Lys Ser Ser Glu Val <210> 108 <211> 298 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:213087.1.orf2:2000MAY01 <220>
<221> unsure <222> 197, 200 <223> unknown or other <400> 108 Ser Arg Arg Ser Ala Ala Met Ala Gly Gly Arg Gly Ala Pro G1y Arg G1y Arg Asp Glu Pro Pro Glu Ser Tyr Pro Gln Arg Gln Asp His Glu Leu Gln Ala Leu Glu Ala I1e Tyr Gly Ala Asp Phe Gln Asp Leu Arg Pro Asp Ala Cys Gly Pro Val Lys Glu Pro Pro Glu Ile Asn Leu Val Leu Tyr Pro Gln Gly Leu Thr Gly Glu G1u Val Tyr Val Lys Val Asp Leu Arg Val Lys Cys Pro Pro Thr Tyr Pro Asp Val Val Pro G1u Ile Glu Leu Lys Asn Ala Lys Gly Leu Ser Asn Glu Ser Val Asn Leu Leu Lys Ser Arg Leu Glu Glu Leu Ala Lys Lys His Cys Gly Glu Val Met Ile Phe Glu Leu Ala Tyr His Val Gln Ser Phe Leu Ser Glu His Asn Lys Pro Pro Pro Lys Ser Phe His Glu Glu Met Leu Glu Arg Arg Ala Gln Glu Glu Gln G1n Arg Leu Leu Glu Ala Lys Arg Lys Glu Glu Gln Glu Gln Arg Glu Ile Leu His Glu Ile Gln Arg Arg Lys Glu Glu Ile Lys Glu Glu Lys Xaa Arg Lys Xaa Met Ala Lys Gln Glu Arg Leu Glu Ile Ala Ser Leu Ser Asn Gln Asp His Thr Ser Lys Lys Asp Pro Gly Gly His Arg Thr Ala A1a Ile Leu His Gly Gly Ser Pro Asp Phe Val Gly Asn Gly Lys His Arg Ala Asn Ser Ser Gly Arg Ser Arg Arg Glu Arg Gln Tyr Ser Val Cys Asn Ser Glu Asp Ser Pro Gly Ser Cys Glu Ile Leu Tyr Phe Asn Met Gly Ser Pro Asp Gln Leu Met Ala Pro Lys Gly Lys Cys Ile Gly Ser Asp Glu Gln Leu <210> 109 <211> 89 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:405330.1.orf3:2000MAY01 <400> 109 Tyr Lys Phe Leu Ala Glu Ser Ala Thr Leu Asn Tyr Val Ala Asp Arg Gln Ala Ser Thr Leu Gln Leu G1y Thr Lys Cys Phe His Cys Arg Ile Ser Ser Arg Leu Lys Thr Glu Arg Leu Val Lys Thr Lys Cys Leu Lys Arg Val Arg Cys Leu Gly Trp Ala Cys Asp Val Leu Ser Gly Leu Ala Leu Leu Asp Gly Thr Leu Arg Ser Glu Leu Leu Glu Asn Leu His Leu Lys Gly Glu Ala Phe Arg Lys G1n Ser <210> 110 <211> 771 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:350243.2.orf2:2000MAY01 <400> 110 Asn Arg Glu Lys Ile Pro Phe Gln Glu Pro Lys Va1 Ser Pro Va1 Pro Leu Pro Leu Pro Ser Pro His Ser Lys Ser Thr Pro Ser Arg Gln Pro Pro Ser Leu Ala Ala Ser Pro Gly Ser Ser Ser Gly Leu Thr Ala Thr Val Ala Gln Ala Met Pro Tyr Ser Pro Gln Leu Lys Pro Ile Gln Pro Ile Ala His Cys Tyr Gly Arg Thr Phe His Ser Gln Pro Cys Leu Asp Ser Ser Gln Gly Gln Glu Lys Glu Arg Gln Ile Ile Glu Gly Ile Phe Lys Gly Thr Cys Lys Ser Ser Asp Pro Trp Asp Thr Leu Va1 Glu Gln Met Val Ser His Tyr Ser Pro Phe Arg Glu Ser Ser Gly Asn Gly Met Lys Met Glu Gly Leu Leu Asn Gly Ser Ser Asp Pro His Gln Ser Arg Leu Ala Ser Ile Lys Ala Glu Ala Asp Lys Ile Tyr Ser Phe Thr Asp Asn Ala Pro Ser Pro Ser Ile Gly Gly Ser Ser Arg Leu Glu Asn Thr Thr Pro Thr Gln Pro Leu Thr Pro Leu His Val Val Thr Gln Asn Gly Ala Glu Ala Ser Ser Val Lys Thr Asn Ser Pro A1a Tyr Ser Asp Ile Ser Asp Ala Gly Glu Asp Gly Glu Gly Lys Val Asp Ser Val Lys Ser Lys Asp Ala Glu Gln Leu Va1 Lys Glu Gly Ala Lys Lys Thr Leu Phe Pro Pro Gln Pro Gln Ser Lys Asp Ser Pro Tyr Tyr Gln Gly Phe Glu Ser Tyr Tyr Ser Pro Ser Tyr Ala Gln Ser Ser Pro Gly Ala Leu Asn Pro Ser Ser Gln A1a Gly Val Glu Ser Gln Ala Leu Lys Thr Lys Arg Asp Glu Glu Pro Glu Ser Ile G1u Gly Lys Val Lys Asn Asp Ile Cys Glu Glu Lys Lys Pro Glu Leu Ser Ser Ser Ser Gln Gln Pro Ser Val Ile Gln Gln Arg Pro Asn Met Tyr Met Gln Ser Leu Tyr Tyr Asn Gln Tyr A1a Tyr Val Pro Pro Tyr Gly Tyr Ser Asp G1n Ser Tyr His Thr His Leu Leu Ser Thr Asn Thr Ala Tyr Arg Gln Gln Tyr Glu Glu Gln Gln Lys Arg Gln Ser Leu Glu Gln Gln Gln Arg Gly Val Asp Lys Lys Ala Glu Met Gly Leu Lys Glu Arg Glu Ala Ala Leu Lys Glu G1u Trp Lys Gln Lys Pro Ser Ile Pro Pro Thr Leu Thr Lys A1a Pro Ser Leu Thr Asp Leu Val Lys Ser Gly Pro Gly Lys Ala Lys G1u Pro Gly Ala Asp Pro Ala Lys Ser Val Ile Ile Pro Lys Leu Asp Asp Ser Ser Lys Leu Pro G1y Gln Ala Pro G1u G1y Leu Lys Val Lys Leu Ser Asp Ala Ser His Leu Ser Lys Glu Ala Ser Glu Ala Lys Thr Gly Ala Glu Cys Gly Arg Gln Ala Glu Met Asp Pro Ile Leu Trp Tyr Arg Gln Glu Ala Glu Pro Arg Met Trp Thr Tyr Val Tyr Pro Ala Lys Tyr Ser Asp I1e Lys Ser Glu Asp Glu Arg Trp Lys Glu Glu Arg Asp Arg Lys Leu Lys Glu Glu Arg Ser Arg Ser Lys Asp Ser Va1 Pro Lys Glu Asp Gly Lys Glu Ser Thr Ser Ser Asp Cys Lys Leu Pro Thr Ser Glu Glu Ser Arg Leu Gly Ser Lys Glu Pro Arg Pro Ser Val 560 ~ 565 570 His Val Pro Val Ser Ser Pro Leu Thr Gln His Gln Ser Tyr Ile Pro Tyr Met His Gly Tyr Ser Tyr Ser Gln Ser Tyr Asp Pro Asn His Pro Ser Tyr Arg Ser Met Pro Ala Val Met Met Gln Asn Tyr Pro Gly Ser Tyr Leu Pro Ser Ser Tyr Ser Phe Ser Pro Tyr Gly Ser Lys Val Ser Gly Gly Glu Asp Ala Asp Lys Ala Arg Ala Ser Pro Ser Val Thr Cys Lys Ser Ser Ser Glu Ser Lys Ala Leu Asp Ile Leu Gln Gln His Ala Ser His Tyr Lys Ser Lys Ser Pro Thr Ile Ser Asp Lys Thr Ser Gln G1u Arg Asp Arg Gly Gly Cys Gly Val Val Gly Gly Gly Gly Ser Cys Ser Ser Val Gly Gly Ala Ser Gly Gly Glu Arg Ser Val Asp Arg Pro Arg Thr Ser Pro Ser Gln Arg Leu Met Ser Thr His His His His His His Leu Gly Tyr Ser Leu Leu Pro Ala Gln Tyr Asn Leu Pro Tyr Ala Ala Gly Leu Ser Ser Thr Ala I1e Val Ala Ser Gln Gln Gly Ser Thr Pro Ser Leu Tyr Pro Pro Pro Arg Arg <210> 111 <211> 247 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:445188.1.orf3:2000MAY01 <400> 111 Val Tyr Ser Glu Asn Met Ser Thr A1a Ile Arg Glu Val Gly Val Trp Arg Gln Thr Arg Thr Leu Leu Leu Lys Asn Tyr Leu Ile Lys Cys Arg Thr Lys Lys Ser Ser Va1 Gln Glu Ile Leu Phe Pro Leu Phe Phe Leu Phe Trp Leu Ile Leu Ile Ser Met Met His Pro Asn Lys Lys Tyr Glu Glu Val Pro Asn Ile Glu Leu Asn Pro Met Asp Lys Phe Thr Leu Ser Asn Leu Ile Leu Gly Tyr Thr Pro Val Thr Asn Ile Thr Ser Ser Ile Met Gln Lys Val Ser Thr Asp His Leu Pro Asp Val Ile Ile Thr Glu Glu Tyr Thr Asn Glu Lys Glu Met Leu Thr Ser Ser Leu Ser Lys Pro Ser Asn Phe Val Gly Val Val Phe Lys Asp Ser Met Ser Tyr Glu Leu Arg Phe Phe Pro Asp Met Ile Pro Val Ser Ser Ile Tyr Met Asp Ser Arg Ala Gly Cys Ser Lys Ser Cys Glu Ala Ala Gln Tyr Trp Ser Ser Gly Phe Thr Val Leu Gln Ala Ser Ile Asp Ala Ala Ile Ile Gln Leu Lys Thr Asn Val Ser Leu Trp Lys Glu Leu Glu Ser Thr Lys Ala Val Ile Met Gly Glu Thr Ala Val Va1 G1u Ile Asp Thr Phe Pro Arg Gly Val Ile Leu Ile Tyr Leu Val Ile Ala Phe Ser Pro Phe Gly Tyr Phe Leu Ala Ile His Ile Val Ala <210> 112 <211> 98 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:244378.1.orf1:2000MAY01 <400> 112 Gly Leu Gly Ser Leu Asn Pro Gly Leu Trp Leu Leu Asn Gly Ser Arg Asn Ser Leu Gly Asn Phe Cys Asp Gly Gln Arg Lys Cys Ser Ser Val Ile Phe Met Asp Glu Ile Asp Ser Phe Gly Ser Ser Glu Leu Glu Gly Asp Ala Gly G1y Asn Ser Glu Va1 Gln Gln Met Met Leu Ser Arg Val Ala Leu Arg Pro Pro Arg Val Ser Arg Thr Val Tyr His Gly Cys Glu Tyr Glu Met Arg Tyr Leu Val Thr Pro Ala Val Phe Val Ala Gln Gly His His <210> 113 <211> 51 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:236574.15.orf1:2000MAY01 <400> 113 Asp Thr Leu Met Lys Thr Trp Thr Ile G1u Trp Ser Arg Asn Ser Pro Leu Ser Leu Thr Tle Thr Val Ala Phe Leu Trp Ser Ser Ser Ser Pro Arg I1e Pro Lys Thr Ala Ala G1u Phe Ile Lys Ile Lys Phe Val Asn Val Thr Thr <210> 114 <211> 94 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:010100.20.orf3:2000MAY01 <400> 114 Ile Leu Leu Leu G1u Ala Ala Leu Ala Trp Glu Val Leu G1u Trp Glu Ala Tyr Gly Arg Asp Gly Met Arg His Val Lys Phe Leu Lys Tyr Val Arg Val Ser Cys Leu Ser Met Ser Leu Asn'Phe Phe Ser Phe Phe Phe Leu Lys Ile Ile Arg Glu Ala Met Asp G1n Leu G1u Glu Trp Glu Trp Gly Thr Ile Thr Val Glu Asp Met Va1 Leu Leu Met Val Trp Val Val Met Val Ser Ile Ser Ser Ser Val Cys Val Ser Pro His Met <210> 115 <211> 64 <212> PRT
<2l3> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:037940.6.orf1:2000MAY01 <400> 1l5 Ala His Ala Glu Asp Ser Val Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe Gly Asp Pro Trp Pro Pro Arg Thr Trp Arg Gln Gly Arg Thr Arg Trp Thr Trp Ala Trp Trp Ala Pro Lys Pro Trp Gln Gln Asp Arg Gln Val Lys Cys Phe Cys Ser <210> 1l6 <21l> 238 <2l2> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:228550.3.orf2:2000MAY01 <400> l16 Trp Met Val Leu Ser Leu Trp Arg Leu Cys Thr Cys Leu Phe Leu Ala Pro Ser Arg G1n G1y Gly Gly Ser Gln Ala Leu Pro Ser Ser Met Ala Pro Trp Pro Pro Gly Pro Ser Thr Val Val Va1 Glu Pro His Gln Trp Pro Leu Gly I1e Arg Leu Asn Ala Gly Gly Thr Phe Cys Trp Pro Thr Leu Arg Ala Val Met Gln Arg Pro Phe Pro Gln Ala Cys Val Phe Thr His Leu Pro Ser Leu Ala Phe Ala Val Thr Gly Arg Glu Glu Pro Ser Arg Asp Pro Trp Trp Pro Thr Cys Gly Cys His Met Leu Leu Phe Pro Ala Cys Pro Ala Thr Thr His Ala Leu His Arg Val Arg Trp Ser His Gly Gly Ala Ser Phe Thr Gln Gln Pro Ser Asn Pro Asp Ala Val Gly Arg Ala Gly Ser Leu Gly Tyr His His Pro Cys Gly Cys Thr Ala Val Pro Cys Ser Ser Gly Ser Gly Phe Pro Ala Val Thr Ser Lys Pro Ala Cys Pro Val Cys Trp Gly Trp Leu Ser Phe Gly Leu Pro Ile Thr Gly Arg Leu Val Glu Lys Ala Val Pro Arg Gly Arg Thr Arg Pro Arg Arg Gln Leu Pro Ala Leu Pro Gln Lys Cys Gln Asp Val His Gln Pro Leu Ala Arg Ala Arg Ser Arg Gln Ser Thr Val Thr Gly Glu Cys <210> 117 <211> 202 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:027320.1.orf2:2000MAY01 <400> 117 Arg Pro Gly Arg Cys Leu Arg Ala Val A1a Pro Pro Arg Leu His 1 5 ' 10 15 Ser Gly Ser Pro Pro Arg Ala Pro Pro Pro Pro Leu Glu Ala Leu His Ser Gly Glu Ala Gly Arg Ala Pro Asp Ser Asp Gly Gly Ser Asp Ala Asp Phe Gly Gly Gly Ser Gly Glu Pro Asp Ser Asp Arg Gly Gly Glu Arg Glu Leu Arg Leu Arg Arg Gly Glu Leu Gly Gly Arg Leu Leu Pro Arg Ala Ala Glu Glu Glu Met Ala G1y Pro Asn Gln Leu Cys Ile Arg Arg Trp Thr Thr Lys His Val Ala Val Trp Leu Lys Asp Glu Gly Phe Phe Glu Tyr Val Asp Ile Leu Cys Asn Lys His Arg Leu Asp Gly Ile Thr Leu Leu Thr Leu Thr Glu Tyr Asp Leu Arg Ser Pro Pro Leu Glu Ile Lys Val Leu Gly Asp Ile Lys Arg Leu Met Leu Ser Val Arg Lys Leu Gln Lys Ile His Ile Asp Val Leu Glu Glu Met Gly Tyr Asn Ser Asp Ser Thr Met Gly Ser Met Thr Pro Phe Ile Ser A1a Leu Gln Ser Thr Asp Trp Leu Cys Asn Gly Glu Leu Ser Pro <210> 118 <211> 172 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:321475.1.orf2:2000MAY01 <400> 118 Ser Leu Ile Ser Lys Glu Asp Phe Lys Gln Met Ser Pro Gly T1e Ile Gln Gln Leu Leu Ser Cys Ser Cys His Leu Pro Lys Asp Gln 20 ~ 25 30 Gln Ala Lys Leu Pro Pro Thr Thr Leu Glu ,Lys Tyr Gly Tyr Ser Thr Val Ala Val Thr Leu Leu Thr Leu Gly Ser Met Leu Gly Thr Ala Leu Val Leu Phe His Ser Cys Glu Glu Asn Tyr Arg Leu Ile Leu Gln Leu Phe Val Gly Leu Ala Val Gly Thr Leu Ser Gly Asp Ala Leu Pro Pro Pro Tyr Pro Ser G1y Ser Cys Val Tyr Ile Ser Arg Lys Pro Gln Asn Leu Gly I1e Ser Met Lys Ala Lys Val Asn Ile Trp Lys Leu Met Gly Leu Ile Gly Gly Ile His Gly Phe Val Leu Asp Arg Thr Asn Val Leu Phe Phe Leu Tyr His.Gln Met Thr Ser Arg Ala Cys His Trp Leu Met Gly Thr Trp Val Ile Pro Thr Ile Leu His Ser Thr Leu Asn <210> 119 <211> 166 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:899552.5.orf1:2000MAY01 <400> 119 Val Asn Ile Lys Ser Pro Gln Pro His Leu Glu Gly Phe His Pro Ala Arg Ala Cys Leu Leu Leu Ser Thr Leu Leu Gly Val Thr Tyr Glu Cys His Ser Cys Asn Ser Glu Val Pro Thr Lys Pro Arg Ala Leu Ala Ser Ser Gly Val Arg Pro Leu Phe Arg Val Leu Arg Thr Ala Val Val Val Gln Val Thr Pro Lys Gly Met Arg Arg Lys Gly Ser Met Ser Ser Lys Ala Gln Gly Ser Gln Asp Ser Ser Pro Pro Phe Ser Pro Gly Thr Ser Arg Glu Ala Arg Gly Phe Thr Leu Cys Thr Phe Leu Leu Leu Leu Lys Cys Pro Ala Val Cys Leu Pro Gly Gln Lys Phe Gly Ala Thr Gln Ala Gly Leu Thr Met Pro Gln Val Leu Ile Trp Arg Ala Glu Arg Ser Asp Ala Gly Thr Tyr Lys Glu Glu Arg Lys Glu Glu Arg Leu Thr Leu Thr Arg Leu Leu Arg Arg Gly <210> 120 <211> 194 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1071848.1.orf2:2000MAY01 <400> 120 Ala Gly Arg Arg Arg Pro Leu Arg Ser Arg Lys Met Ser Arg Ser Gly Ala Ala Ala G1u Lys Ala Asp Ser Arg Gln Arg Pro Gln Met Lys Val Asn Glu Tyr Lys Glu Asn Gln Asn Ile Ala Tyr Val Ser Leu Arg Pro Ala Gln Thr Thr Val Leu Ile Lys Thr Ala Lys Val Tyr Leu Ala Pro Phe Ser Leu Ser Asn Tyr Gln Leu Asp Gln Leu Met Cys Pro Lys Ser Leu Ser Glu Lys Asn Ser Asn Asn Glu Val Ala Cys Lys Lys Thr Lys Ile Lys Lys Thr Cys Arg Arg Ile Ile Pro Pro Lys Met Lys Asn Thr Ser Ser Lys Ala Glu Ser Thr Leu Gln Asn Ser Ser Ser Ala Val His Thr Glu Ser Asn Lys Leu Gln Pro Lys Arg Thr Ala Asp A1a Met Asn Leu Ser Val Asp Val Glu Ser Ser Gln Asp Gly Asp Ser Asp Glu Asp Thr Thr Pro Ser Leu Asp Phe Ser Gly Ile Val Thr Leu Arg Lys Glu Glu Thr Glu Glu His Ile Arg Lys Arg Arg Leu Phe Cys Phe Ser Ser Val Val <210> 121 <211> 313 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1072337.2.orf2:2000MAY01 <400> 121 Leu Leu Leu Pro Ala Ala Ser Ala His G1n Thr Ala Thr Gly Pro Ala G1u Gly Phe Trp Gly Pro Pro Va1 Leu Met Leu Lys Arg Ser Lys Asn Phe G1u Pro Ser Ala Cys His Gly Lys Asn Val Val Val Thr Ala Asp Cys Ile Val Thr Gln Lys Arg Val Pro Ala Ala Arg Leu Gly Ile Lys Cys Gln Val Ser Gly Ser His Val Leu Ser Met Trp Ala Ala Ser Arg Asp Gly Cys Gly Asn Met Ala Gly Arg Ile Glu Phe Asn Pro I1e Arg Val Arg Thr His Tyr Leu His Thr Ile Met Lys Leu Glu Leu Glu Ser Lys Arg Gln Val Ser Arg Pro Ala Ala Pro Asp Glu Glu Pro Ser Pro Thr Ala Ser Cys Ser Leu Thr Gly Ala Gln Gly Ser G1u Thr G1n Asp Phe Gln Glu Phe Ile Ala Glu Asn Glu Thr Ala Val Met His Leu Gln Ser Ala Glu Glu Leu Glu Arg Leu Lys Ala Glu Glu Asp Ser Ser Gly Ser Ser Ala Ser Leu Asp Ser Ser Ile Glu Ser Leu Gly Val Cys Ile Leu Glu Glu Pro Leu Ala Val Pro Glu Glu Leu Cys Pro Gly Leu Thr Ala Pro Ile Leu Ile Gln A1a G1n Leu Pro Pro Gly Ser Ser Val Leu Cys Phe Thr Glu Asn Ser Asp His Pro Thr Ala Ser Thr Val Asn Ser Pro Ser Tyr Leu Asn Ser Gly Pro Leu Val Tyr Tyr Gln Val Glu Gln Arg Pro Val Leu Gly Val Lys Gly Glu Pro Trp Tyr Gly Arg Arg Leu Ser Leu Phe Pro Lys Gly Glu Gly Ser Glu Cys Leu Leu Ser Pro Cys Tyr Leu Thr Arg Gly Leu Val Ala Pro Gln Thr Gln Leu Pro Ser Val Asn Gln Arg Trp Gly Lys His Pro Pro <210> 122 <211> 126 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:251489.5.orf2:2000MAY01 <400> 122 Gln Lys Phe Pro Met Gly Lys Gly Pro Ser Phe Asn Gln Glu Arg Gly Thr Ser Ser His Leu Pro Pro Pro Thr Lys Val Ala Cys Thr Ala Ala Ser Thr Ser Arg Ser Thr Gly Ser Thr Trp Glu Asp Gln Ala Pro Phe Pro Pro Ser Ser Lys Val Ala Asp Glu Asp Glu Ile Leu Glu Ala Lys Thr Lys Thr Thr Ile Arg Asn Phe Cys Ser Ser Arg Ile Val Leu Val Asn Gly Val Lys Arg Lys Ser Glu Glu Trp Lys Asn Lys Ala Lys Ala Ala Cys Ala Glu Lys Leu Lys Arg Leu Ala Asp Glu Ala Trp His Pro Gly Lys Thr Thr Ile Ser Arg Gly Asn Gln Gly Lys Gly A1a <210> 123 <211> 911 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:902018.107.orf2:2000MAY01 <220>
<221> unsure <222> 55 <223> unknown or other <400> 123 Thr A1a Trp Gln Cys Gln G1y Arg Va1 Gly Val Ser Pro His Cys Pro Ala Ser Val Gly Gln Pro Asn Thr Va1 Cys Leu Val Val Cys Val His Met Cys Ala Cys Val Cys Pro Ala G1u G1n Gln Thr Ala Ala Pro Glu Ser Cys Gly Ala Phe Pro Xaa Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu Lys His Val Gly Phe Ser Leu Asp Val Gly Glu Ile Glu Lys Lys Gly Lys Gly Lys Lys Arg Arg Gly Arg Arg Ser Lys Lys Glu Arg Arg Arg Gly Arg Lys Glu Gly Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Tyr Leu Glu Leu Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala Val Tyr Ser Leu Glu Glu Gln Tyr Leu Gly Leu Ala 15'5 160 165 Leu Asp Val Asp Arg Ile Lys Lys Asp Gln Glu Glu Glu Glu Asp Gln G1y Pro Pro Cys Pro Arg Leu Ser Arg Glu Leu Leu Glu Val Val Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Ser Cys Leu Glu Gln Pro Asp Ser Cys Gln Pro Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu Lys His Val Gly Phe Ser Leu Asp Val Gly Glu Asp Gln Arg Arg Lys Glu Glu Gly Glu Glu Lys Lys Gly Lys Lys Ile Lys Thr His His Ala Pro Gly Leu Ser Arg Glu Leu Leu Asp Glu Lys Gly Pro G1u Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro Tyr Arg Ser Ala Phe Tyr Ile Leu Glu Gln Gln Arg Val Gly Leu A1a Val Asp Met Asp Glu Ile Glu Lys Tyr Gln Glu'Val Glu Glu Asp Gln Asp Pro Ser Cys Pro Arg Leu Ser Gly Glu Leu Leu Asp Glu Lys Glu Pro Glu Val Leu Gln Glu Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro Tyr Arg Ser Ala Phe Tyr Ile Leu Glu Gln 3'80 385 390 Gln Arg Val Gly Leu Ala Val Asp Met Asp Glu I1e G1u Lys Tyr Gln Glu Val Glu Glu Asp Gln Asp Pro Ser Cys Pro Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys Glu Pro Glu Val Leu Gln Asp Ser Leu Gly Arg Cys Tyr Ser Thr Pro Ser Gly Tyr Leu Glu Leu Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala Va1 Tyr Ser Leu Glu Glu Gln Tyr Leu Gly Leu Ala Leu Asp Val Asp Arg Ile Lys Lys Asp Gln G1u Glu Glu Glu Asp Gln Gly Pro Pro Cys Pro Arg Leu Ser Arg Glu Leu Leu Glu Val Val Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Ser Cys Leu Glu Gln Pro Asp Ser Cys Gln Pro Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu Lys His Val Gly Phe Ser Leu Asp Val Gly Glu Ile Glu Lys Lys Gly Lys Gly Lys Lys Arg Arg Gly Arg Arg Ser Lys Lys Glu Arg Arg Arg Gly Arg Lys Glu Gly Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys Gly Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro Tyr Arg Ser Ala Phe Tyr Val Leu Glu Gln Gln Arg Val Gly Leu Ala Val Asp Met Asp Glu Ile Glu Lys Tyr Lys Glu Val Glu Glu Asp Gln Asp Pro Ser Cys Pro Arg Leu Ser Arg Glu Leu Leu Asp G1u Lys Glu Pro Glu Val Leu G1n Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Tyr Leu Glu Leu Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala Val Tyr Ser Leu Glu Glu Gln Tyr Leu Gly Leu A1a Leu Asp Val Asp Arg Ile Lys Lys Asp Gln Glu Glu Glu Glu Asp Gln Gly Pro Pro Cys Pro Arg Leu Ser Arg Glu Leu Leu Glu Val Val Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Ser Cys Leu Glu Gln Pro Asp Ser Cys Gln Pro Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu Lys His Val Gly Phe Ser Leu Asp Val Gly Glu Ile Glu Lys Lys G1y Lys Gly Lys Ile Arg Arg Gly Arg Arg Ser Lys Lys Lys Arg Arg Arg G1y Arg Lys Glu Gly Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu Asn Ser Val Leu Met Glu Val Glu Glu Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Met Tyr Cys Glu Leu Arg Asp Ser Phe Gln His Tyr Arg Ser Val Phe Tyr Ser Phe Glu Glu Gln His Ile Ser Phe Ala Leu Asp Met Asp Asn Arg Phe Phe Thr Leu Thr Val Thr Ser Leu Tyr Leu Val Phe Gln Met Gly Val Ile Phe Pro Gln <210> 124 <211> 198 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:220495.1.orf1:2000MAY01 <220>
<221> unsure <222> 191 <223> unknown or other <400> 124 Arg Phe Trp Leu Pro His Asn Va1 Thr Trp Ala Asp Leu Lys Asn Thr Glu Glu Ala Thr Phe Pro Gln Ala Glu Asp Leu Tyr Leu Ala Phe Pro Leu Ala Phe Cys T1e Phe Met Val Arg Leu Ile Phe Glu Arg Phe Val Ala Lys Pro Cys Ala Ile Ala Leu Asn Tle Gln Ala Asn Gly Pro Gln Ile Ala Pro Pro Asn Ala Ile Leu Glu Lys Val Phe Thr Ala I1e Thr Lys His Pro Asp Glu Lys Arg Leu G1u Gly Leu Ser Lys Gln Leu Asp Trp Asp Val Arg Ser Ile Gln Arg Trp Phe Arg Gln Arg Arg Asn Gln Glu Lys Pro Ser Thr Leu Thr Arg Phe Cys Glu Ser Met Trp Arg Phe Ser Phe Tyr Leu Tyr Val Phe Thr Tyr Gly Val Arg Phe Leu Lys Lys Thr Pro Trp Leu Trp Asn Thr Arg His Cys Trp Tyr Asn Tyr Pro Tyr Gln Pro Leu Thr Thr Asp Leu His Tyr Tyr Tyr Ile Leu Glu Leu Ser Phe Tyr Gly Ser Trp Met Leu Phe Ser Val His Trp Ile Ser Xaa Arg Ile Arg Thr Cys Gly Asp <210> 125 <211> 205 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:399478.1.orf3:2000MAY01 <400> 125 Ala Asp Ser Arg Ser Pro Ala Thr Ala Ala Ser Pro Ser Ala Pro Ala Leu Pro Val His Ser Pro Gln Pro Pro Ser Ala Lys Pro Gln Arg Pro Leu Pro Ser Pro Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys Thr A1a Leu Val G1n Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr Ser Gly Asp Pro Glu Leu Pro Gln Val <210> 126 <211> 121 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:229648.2.orf1:2000MAY01 <400> 126 Asp Asp Cys Met Leu Thr His Pro Leu Gln Gly Pro Gly Leu Asp Leu Gly Leu His Cys I1e Leu Ser Asn Gly Leu Ala Gly Ala Pro Phe Gly Leu Leu Ser Leu Phe Ser Pro Glu Leu Gly Trp Trp Glu Lys Arg Gly Trp Ser Glu Ser Ile Ser Ile G1n Ile Pro Ala Gly Ile Thr Leu Gly Val Phe Leu Ala Cys Met Gly Leu Lys Leu Ser Tyr Ile Val Tyr Trp Leu Pro Lys Ser G1y Leu Lys Ser Glu Lys Met Gln Ala Met Asn Pro Ser Ala His Ser Ser Pro Thr Phe Pro Ala Leu Phe Tyr Leu Gly Gly Gln Trp Lys Gly Gly Glu Ala Met Pro <210> 127 <211> 193 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:025643.2.orf3:2000MAY01 <400> 127 Leu Lys Trp Ile Pro Ser Ser Pro Gly Lys Leu Asn Glu Ala Asp His Asn Gly Asp Leu Ala Leu Arg Ile Leu Ala Pro Leu Thr Thr Thr Gly Glu Val Asn Cys Gln Pro Arg Trp Leu Val Thr Lys Leu Met Trp Thr Trp Trp Thr Lys Ser Gly Trp Ser Leu Val Thr Pro Arg G1y Phe Gln Arg Arg Arg Ser Leu Va1 Leu Pro Leu Ser Tyr Ile Asn Glu Trp Arg Pro Cys Val Asn A1a Ala Thr Leu Gly Ala Pro Gly Asp Thr Thr Cys Thr Phe Va1 Gly Leu Cys Thr Ser Ser Thr Arg Asn Thr Gln Leu Asp Va1 Met Pro G1u Met Ala A1a Asp Cys Arg Gly Pro Ser Ala Gly Trp Val Pro Thr Pro Asn Met Gln Asp Ser Lys Gly Arg Thr Pro Val Thr Cys Val Pro Ser Met Ala Ala Gly Tyr Asp Ile Cys Val Ser Val Ser Cys Ser Ser Arg Lys G1n Leu Asp Leu Glu Leu Asn Arg Pro Arg Gly Gln Ala Gln Ala Thr Val Ala Trp Leu Val Gln His Ile Thr Ser Val Phe <210> 128 <211> 116 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:233942.1.orf2:2000MAY01 <400> 128 Asp Ser Gln Cys Met Arg Ser Gln Pro Arg Glu His Leu Phe Phe Thr Phe Leu Leu Lys Ile His Trp Gly Gly Ile Lys Phe Thr Pro Lys Lys Phe Ala Trp Ala Lys Ser Leu Gln Val Pro Ser Glu Asn Lys Ile Leu Met Ile Phe Phe Phe Phe Trp Leu Leu Gly Arg Asp Phe Gln His Ser Phe Thr Ile Ser Gln Ile Cys Pro Phe Ser Thr His Thr G1n Leu Ser His Leu Val Arg Phe I1e Leu Pro Lys G1u Arg Cys Ser Pro Thr Leu Thr Leu Phe Gln Arg Ala Thr Leu Ser Gln Pro Gln Gln Pro Cys Gln Glu Lys Ala Arg <210> 129 <211> 186 <212 > PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:089158.1.orf1:2000MAY01 <220>
<221> unsure <222> 29, 36, 38-39, 49 <223> unknown or other <400> 129 Leu Ser Asp Phe Arg Leu Leu His Leu His Glu Leu Gly His Lys Val Pro Val Met Ser Asn Cys Gln Ser Gly Pro Ser Ile Xaa Arg Ser Ala Ser Pro Lys Xaa Pro Xaa Xaa Glu Asn Leu Pro G1y Ala Gln Ala Lys Xaa Trp Val Arg Thr Arg Thr Val Ala Cys Trp Tyr Cys Arg Asp Ala Ala Ser Val Pro Ser Ser Pro His Arg Pro Arg Ser Ile Ser Leu Ser Arg Val Gly Leu Leu Leu A1a Ala Thr Gly Ile Leu Gln Pro Leu Ile Trp Leu Ser Ser Val Ser Glu I1e Ser 95 100 l05 Ile Cys Arg Gly Ser Leu Gly A1a Gln Thr Val Thr Ser Asn Trp Glu Val Lys Cys Trp Trp Val Lys Phe Thr Ile Val Ser Thr Leu Leu Leu His Phe Leu Pro Ser Ser Gln Lys Met Glu Ser Gln Leu Leu Glu Thr Leu Met Thr Ser Ser Ser Arg Arg Leu Ala Leu Pro 155 160 . 165 G1n Thr His Asp Thr Ser Thr Thr Glu Pro Ser Ser Leu Asp Pro His Asp Phe Asp Arg Asn <210> 130 <211> 90 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:101046.1.orf2:2000MAY01 <400> 130 Thr Tyr Gln Pro Gly Phe Ser Leu Thr Lys Asp Asn Pro Arg Gly Ser Leu Asp Gln Pro His Leu Ser Gly Ser Pro Phe Ser Ser Ser Phe Lys Ser Pro Ser Phe Leu Gln Ile Ser Ser Arg Leu Ala Ala Leu Lys Asp Asn Pro Leu Leu Pro Ala Ala Leu Leu Cys Leu Lys Gly Lys Gly Leu Ala His Ile Phe Ser Val Trp Pro Pro Pro Pro Gly His Thr Ala Phe Phe Leu Ala Pro Phe Leu Thr Leu Leu Thr <210> 131 <211> 167 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:368676.2.orf1:2000MAY01 <400> 131 Glu Ser Leu Cys His Arg Asp Pro Arg Lys Asn Tle Glu Leu Tyr Val Arg Pro Met Ser Leu Leu Gly Glu Val Gln Leu Gln Pro Ser Thr Ser Leu Leu Pro Thr Leu Asn Arg Thr Phe Tle Trp Asp Val Lys Ala His Lys Ser Ile Gly Leu Glu Leu Gln Phe Ser Ile Pro Arg Met Arg Gln Ile Gly Pro Val Lys Ser Cys Pro Asp Gly Val Thr Asn Ser Ile Ser Gly Arg Ile A1a Ala Thr Val Val Arg I1e Gly Thr Phe Cys Ser Asn Gly Thr Val Ser Arg Ile Gln Asp Ala Arg Arg Ser Glu Asn Gly Leu Thr Pro Pro Met Gly Ser Thr Pro Glu Asn Val Ser Gly Phe Ser Ile Glu Thr Arg Ser Ser Ile Lys Arg Leu'Cys Ile Ile Glu Ser Val Phe Glu Gly G1u Gly Ser Ala Thr Leu Asn Val Cys Gln Leu Pro Thr Lys Ala Pro Leu Arg Met Ser Ser <210> 132 <211> 249 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:238713.1.orf2:2000MAY01 <400> 132 Val Lys Leu Lys Glu Leu Phe Asn Arg Ile Leu Arg Asn Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys Gln Glu Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg Asp Gly Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser Pro Thr Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly Arg Gln Ser Met Val Thr Leu Lys Ser Ser Thr Asn Phe Phe Glu Leu Gln Glu Ser Ile Ala Arg Glu Phe Asn Ile Pro Pro Tyr Leu Gln Cys Ile Arg Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly Met Glu Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile Glu Ile Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His Ser Ala His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu Ser Ser Lys Glu Leu Gln G1u Gln Ala Glu Lys Glu Met Tyr Ser Leu Cys Leu Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys Gly Leu Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met Lys Lys Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His Leu Pro Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg <210> 133 <211> 110 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:720928.1.orf3:2000MAY01 <400> 133 Thr Phe Thr His Met His Ile Ile Thr Gly Thr Gln Thr Phe Thr His Met His Ile Ile Thr Gly Thr Gln Thr Tyr Thr His Met His Ile Leu Met Gly Thr Gln Thr Phe Thr Arg Met His Ile Leu Met Gly Thr Gln Thr Phe Thr His Met His Met Leu Met Gly Thr Gln I1e Phe Thr Tyr Met His Lys Ile Met Gly Thr Gln Thr Phe Thr His Met His Met Ile Thr Gly Thr Gln Thr Tyr Gly Ser Thr Gly Leu Trp Ala His Ser Leu Gln His Lys His Thr Asp Val Pro Pro Ile Phe Leu Arg Val <210> 134 <211> 225 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:221874.1.orf2:2000MAY01 <400> 134 Ile Gln Pro Ser Val Ser Lys Asn Asp Tyr Gln Asn Gly Val Cys Phe Val Arg Leu Gly Thr Met Ser Leu Ser Thr Glu Gly Glu Glu Glu Thr Val Thr Thr Leu Asp Tyr Ser His Cys Ser Phe Arg Thr Ser Ser Gly Lys Arg Phe Leu Leu Leu Lys Lys Leu Leu Glu Glu Leu Tyr Leu Asp Ala Asn Gln Ile Glu Glu Leu Pro Lys Gln Leu Phe Asn Cys Gln Ser Leu His Lys Leu Ser Leu Pro Asp Asn Asp Leu Thr Thr Leu Pro Ala Ser I1e Ala Asn Leu Ile Asn Leu Arg Gly Thr Gly Cys Gln Gln Glu Trp Asn Thr Gly Val Ser Arg Lys Leu Ser Lys Ile Val Lys Cys Leu Thr Ile Val Glu A1a Ser Val Asn Pro Ile Ser Lys Leu Pro Asp Gly Phe Ser Gln Leu Leu Asn Leu Thr Gln Leu Tyr Leu Asn Asp Ala Phe Leu Glu Phe Leu Pro Ala Asn Phe Gly Arg Leu Thr Lys Leu Gln Ile Leu Glu Leu Arg Glu Asn Gln Leu Lys Met Leu Pro Lys Thr Met Asn Arg Leu Thr Gln Leu Glu Arg Leu Asp Leu Gly Ser Asn G1u Phe Thr Gly Ser Ala Leu Lys Val Arg <210> 135 <211> 198 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LT:1143545.3.orf2:2000MAY01 <400> 135 Ala Glu Cys Gln Ala Thr Pro Pro Ala Val Trp Val Val Pro Arg Leu Ala Thr Leu Arg Arg Arg Gly Ser Gln Ser Phe Ser Ala Trp Thr Ala Leu Val Arg Arg Gly Pra Leu Arg Met Gly A1a Ala Arg Arg Tyr Pro Asp Ser Met Glu Ala Pro Thr Arg Ile Arg Asp Thr Pro Glu Asp Ile Va1 Leu G1u Ala Pro Ala Ser Gly Leu Ala Phe His Pro Ala Arg Gly Pro Tyr Trp Leu Gln Gly Thr Trp Thr Gly Thr Cys Ser Ser Phe Pro Thr Leu Ala Lys Arg Glu Lys Pro Arg Ser Ser Gly His Gln Val Thr Ile Ser Arg Pro Ser Glu Leu Trp Ala Phe Ser Glu Asp Gly Gln Lys Leu Ile Thr Val Ser Lys Asp Lys Ala Ile His Val Leu Asp Val G1y Ala Gly Pro Thr G1y Lys Thr Cys Phe Pro Arg Leu Met Val Pro Pro Ser Ile Val Phe Cys Trp Trp Met Arg Met Phe Trp Pro Leu Gly Met Thr Pro Gly Gly Ile Arg Ser Leu Gly Pro Ala Glu Gly Gly Pro Leu Asn Gly Tyr Glu Ala Thr <210> 136 <211> 147 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1143605.1.orf1:2000MAY01 <400> 136 Thr Tyr Ser Ile Trp Ala Ser Ser Cys Lys Asn Lys Ala Glu Cys Asn Glu Leu His Pro Ser Val Ser Val Val Gln Ile Leu A1a Phe Ile Leu Ile Arg Asn Ile Pro Gly Tyr Ala Arg Ser Va1 Tyr Ser Ser Phe Phe Ala Trp Phe Gly Lys Ile Ser Leu Glu Leu Phe Ile Cys Gln Tyr His Ile Trp Leu Ala Ala Asp Thr Arg Gly Tle Leu Val Leu Ile Pro Gly Lys Pro Tyr Ala Gln His His Cys Gln His Phe His Ile Cys Leu Cys G1y His Met Lys Phe Leu Arg Ser Leu Met Ile Leu His Arg Leu Leu Phe Ala Lys Asp Asn Ser Ser Leu Leu Lys Arg Leu Ala Cys Ile Ala Ala Phe Phe Phe Cys Gly Leu Leu Ile Leu Ser Ser Ile Gln Asp Lys Ser Lys His <210> 137 <211> 153 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:474069.7.orf1:2000MAY01 <220>
<221> unsure <222> 60 <223> unknown or other <400> 137 Arg Ser Cys Val Leu Asn Ser Asp His Met Ile His Ser His Ser Pro Arg Tyr Arg Ser Gly Ser Val Asn Leu Asn Gly Cys Cys Glu His Arg Arg Ala Leu Ile Ser Thr Ala Val Asn Pro Lys Leu Lys Asp Ala Val Gln Ala Arg Lys Arg Gly Ile Tyr Leu Asn Thr Xaa Leu Leu Ile Val Val Lys Leu Leu Phe Asp Gly Ser Ala Phe Ala Met Lys Phe Pro Glu Lys Lys Ser Tyr Glu Tyr Lys Ile Leu Lys Lys Ser Ser Thr Val Leu Pro Leu Ser Glu Ser Leu Phe Pro Phe Leu Asp Pro Pro Val Met Leu Cys Asp Tyr Lys Phe Asp Asp Glu Ser Ala Glu G1u Ile Arg Asp His Phe Met Glu Met Leu Asp His Thr Ile Gln Ile Glu Asp Leu Gly Asn Cys Arg Gly Asn Lys His Ser Leu Tyr <210> 138 <211> 279 <212> PRT

<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:245193.3.orf1:2000MAY01 <400> 138 Val Arg Leu Ala Val Ala Thr Thr Glu Glu Glu Gly Arg Asp Ala Val Glu His Gly Asp Arg Leu Ser Val Met Glu Gly Ser Gly Glu Gln Pro Gly Pro Gln Pro Gln His Pro G1y Asp His Arg Ile Arg Asp Gly Asp Phe Val Val Leu Lys Arg Glu Asp Val Phe Lys Ala Val Gln Val Gln Arg Arg Lys Lys Val Thr Phe Glu Lys Gln Trp Phe Tyr Leu Asp Asn Val I1e Gly His Ser Tyr Gly Thr Ala Phe Glu Val Thr Ser Gly Gly Ser Leu Gln Pro Lys Lys Lys Arg Glu Glu Pro Thr Ala Glu Thr Lys G1u Ala Gly Thr Asp Asn Arg Asn Ile Val Asp Asp Gly Lys Ser Gln Lys Leu Thr Gln Asp Asp Ile Lys Ala Leu Lys Asp Lys Gly Ile Lys Gly Glu Glu Ile Va1 Gln Gln Leu Ile Glu Asn Ser Thr Thr Phe Arg Asp Lys Thr Glu Phe Ala Gln Asp Lys Tyr Ile Lys Lys Lys Lys Lys Lys Tyr Glu Ala Ile Ile Thr Val Va1 Lys Pro Ser Thr Arg Ile Leu Ser Ile Met Tyr Tyr Ala Arg Glu Pro Gly Lys Ile Asn His Met Arg Ile Arg Tyr Thr Ser Pro Asp Val Asp Val Gly Lys Tyr Pro Cys Trp Gln Gln Asn Asp Cys Asp Gly Asn Val Cys Arg Leu Gly Ala G1y Cys Asn Asp Gly Thr Asn G1y Arg Phe Trp Leu His Tyr Ser Ala Ile Pro Trp Arg Arg Thr Cys Ser Gly Ser Asn Ser Met Phe Trp Ile Ser Gln Ile Phe Ser Gln Trp Ser Leu <210> 139 <211> 138 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:403872.1.orf1:2000MAY01 <400> 139 Pro G1y Gly Gly Ser Gly Gly Ser Arg Ala Arg Asp Gly G1y Pro Ala Ala Ser Val Ile Pro Arg Thr Ser Ala Pro Arg Ala Arg Ala Gln Thr Arg Thr His Thr Tyr Thr His Ser Arg Thr His Ser His Lys His Thr Leu Val His A1a Arg Gly Arg Ser Leu Arg Arg Leu 50 55 ' 60 Ala Leu Gly Thr G1n Ala Glu Cys Ser Ser Ala Trp Arg Ala Cys Leu Gly Pro Pro Pro Glu Cys Thr Ser Leu Pro Gly Ala Gly Arg Pro Ser Arg Ala His Trp Arg Thr Leu Arg Cys G1y Thr Leu Gly Gln Phe Phe Asp Gly A1a Val Leu Leu Tyr Gly Val Arg Asn Gly Cys Arg Lys Gln His Ser Thr Lys Leu Phe His His Pro Val Phe Tyr Ile Cys <210> 140 <211> 347 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:1086294.1.orf1:2000MAY01 <400> 140 Gln Gly His Ile Ile Arg Pro Pro Ser Pro Cys Pro Arg Pro Pro Leu Glu Tyr Asn Ser Gly Val Pro Ala Trp Ala Asn Gly Leu Gly Arg Glu Glu Ala Val Ala Glu Gly Ala Arg Arg Ala Leu A1a Trp Leu His Ala Trp Phe Asp Ala Pro Trp Val Ala Gly Ser Phe Ser Val Trp Pro Gly Lys Pro Arg Pro Asp Ala G1y Thr Arg Leu Glu Ser Cys Pro Ser Pro Leu Arg Leu Arg Phe Arg Glu Arg Glu Ala Ala Glu Glu Cys Gly Leu Ser Gly Arg Thr Glu Ala Arg Pro Cys Glu Ala Gly Gln Arg Asn Gly Thr Gly Ala Pro Lys Gln Cys Gly Asn Ser Tyr Trp Arg Cys Pro Pro A1a Pro Arg Ser Met Cys Ala Ser Arg Arg Ile Thr Gly Trp Trp Gly Glu Cys Ser Pro Ser Met Leu Thr Ala Arg Pro Pro G1y Tyr Glu Phe Glu Pro Glu Ala Leu Ser Pro Asn Thr Pro Val Val Pro Ala Met Cys Thr Pro Ala Ser Trp Gln Trp Leu Ala Arg Cys Ser Thr Met Leu Cys Gly Ser Arg Ala Arg His Trp Leu Leu Arg A1a Ser Ser Thr Ser Asn Met Asn Ala Gly Met Asp Gln Glu Asn Gly Gly Ser Trp Ala Ser Cys Leu Pro Thr Ala Ser Glu Ala Ser Ala Ser Gln Leu Pro Arg Arg Pro Cys Pro Gln Gln Tyr Pro Glu Arg Gly Pro Gly Ala Leu Cys Gly Pro Pro Pro Arg Ala Pro Ser Arg Asn Leu Ala Pro Thr Pro Arg Arg Arg Lys Ala Ser Pro Glu Pro Glu Gly Glu Ala Ala Gly Lys Met Thr Thr Glu Glu Gln Gln Gln Arg His Leu Gly Gly Thr Arg Arg Pro Cys Thr Pro Arg Glu Thr Pro Arg Cys Ala Leu Ala His Cys Arg Pro Glu Glu Cys Gly Arg Ser Pro G1y Pro Leu Asp Pro Arg Thr Leu Gly Gly Gly Gly Gly Pro Val Arg Ala Gly Gly Arg Gln Pro <210> 141 <211> 440 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:337514.3.orf1:2000MAY01 <400> 141 Ser Gly Trp Ser Trp Ala Leu Ala Ala Arg Gly Arg Arg Lys Leu Ser Ser Cys Thr Gly Gly Arg Val Arg Ala Val Gly Gly Ser Gly Ala Cys Ala Val Ala Met Ser Val Tyr Ala Arg Gly Pro Gly Pro Arg G1u Ala Val Pro Ser Gly Arg Pro Arg Pro Asp Thr Leu Thr Pro Pro Trp Val Arg Gln Arg Ala Val Thr Gly Thr Phe Cys Ala Ser Trp Thr Pro Leu Arg Asn Arg Arg Ala Gln Arg Met Ala Thr Asp Met Gln Arg Lys Arg Ser Ser Glu Cys Leu Asp Gly Thr Leu Thr Pro Ser Asp Gly Gln Ser Met Glu Arg Thr Glu Ser Pro Thr Pro Gly Met Ala Gln Gly Met Glu Pro Gly Ala Gly Gln Glu Gly Ala Met Phe Val His Ala Arg Ser Tyr Glu Asp Leu Thr Glu Ser Glu Asp Gly Ala Ala Ser Gly Asp Ser His Lys Glu Gly Thr Arg Gly Pro Pro Pro Leu Pro Thr Asp Met Arg Gln Ile Ser Gln Asp Phe Ser Glu Leu Ser Thr Gln Leu Thr Gly Val Ala Arg Asp Leu Gln G1u Glu Met Leu Pro Gly Ser Ser Glu Asp Trp Leu Glu Pro Pro Gly Ala Val Gly Arg Pro Ala Thr G1u Pro Pro Arg Glu Gly Thr Thr Glu Gly Asp Glu Glu Asp Ala Thr Glu Ala Trp Arg Leu His Gln Lys His Val Phe Val Leu Ser G1u Ala Gly Lys Pro Val Tyr Ser Arg Tyr Gly Ser Glu Glu Ala Leu Ser Ser Thr Met Gly Val Met Val Ala Pro Gly Val Leu Pro Gly Gly Arg G1n G1u Arg His Pro Leu His Pro Cys Arg Trp Leu Gln Gly Ser Ile Arg Ala Pro Glu Pro Ala Gly Ala Ser G1y Gly Gly Ser Tyr Ala Ala Val Gly Thr Arg Ala Gly Ala Gly Ala Ala Leu His Leu Leu Pro Asp Pro Lys Pro Ser Tyr Arg Cys A1a Ala Ala Ala Thr Ser Ser Ser Arg Ser Arg Thr Met Ile Cys Gly Ala Tyr Ser Arg Ala Gln Ser Ala Ser Pro Asp Asn Leu Leu Gln Leu Met Ala Arg Asp Pro Ser Phe Leu Met Gly Ala Ala Arg Cys Leu Pro Leu Ala Ala Ala Val Arg Asp Thr Val Ser Ala Ser Leu Gln Gln Ala Arg Ala Arg Ser Leu Val Phe Ser Ile Leu Leu Gly Pro Gln Pro Ala Arg Gly Thr Arg Ala Pro Lys G1y Pro Ile Ser Ala Pro His Arg Pro Ala Pro Ala Leu Gln Pro His <210> 142 <211> 386 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:230711.1.orf3:2000MAY01 <400> 142 Pro Ala Arg Ser Tyr Pro Gly Pro Ser Arg His Leu Glu Thr Pro Pro Ser Cys Cys Thr Phe Val Gly Asp Leu Ala Ala Met Ala Trp Gly Thr Gly Thr Leu Leu Ser Arg Arg Cys Pro Gly Gln Cys Val Val Ser Gly Leu Leu Gln Gly Met Met Gly Leu Leu Gly Ser Pro Gly His Val Phe Pro His Cys Gly Pro Leu Val Leu Ala Pro Ser Leu Val Val Ala Gly Leu Ser Ala His Arg Glu Val Ala Gln Phe Cys Phe Thr His Trp Gly Leu Ala Leu Leu Val Ile Leu Leu Met Val Val Cys Ser G1n His Leu Gly Ser Cys Gln Phe His Val Cys Pro Trp Arg Arg Ala Ser Thr Ser Ser Thr His Thr Pro Leu Pro Val Phe Arg Leu Pro Phe Gly Met Cys Gly Ser Gly Gln Gly Ser Arg Gly Gln Lys Gly Trp Pro Gly Val Leu Thr Pro Ser Pro Thr Phe Trp Leu Leu Ser Thr Pro Ala Arg Leu Ala Gln Lys Val Leu Gly Glu Glu Phe Phe Ser Gln Ser Arg Pro Ser Gly Ala Asp Pro Ser Gly Leu Cys Val Asp Cys Phe Cys Leu Cys Gly Ile Gln Cys Tyr Pro Pro Gly Thr Val Cys Pro His Gln Gly Thr Met Asp Ile Gly Cys Leu Thr Thr Gly Glu Trp Lys Leu Ala Phe Ala Asp Ala Gln Ser Ser Trp Leu Gln A1a Phe Ser Met Ala Leu Ala Ser Leu Pro Pro Va1 Ser Leu Gly Leu Leu Met Pro Cys Val Ala Gly Cys Trp His Leu Ala Ser Pro Gln Pro Ser Asn Met Pro Ala Sex Arg Arg Ala Glu Pro Trp Arg Gly Trp Asp Ser Val Ala Gly Pro G1y Cys Trp Glu Gly Pro Met Gly Thr Ala Ser Ser Phe Pro Gln Arg Gly G1n Ser Gly Ser Ile Ser Arg Leu Asp Leu Ser Lys Trp Ala His Tyr Ser Gly Ala Thr Leu Ala Trp Gly Tyr Gly Leu Sex Pro Gln Val Trp Leu Ser Ser Ser Pro Pro Ser His Cys Leu Leu Ile Gly Gly Val His Gly Gly Arg Thr Gln Ala Cys Gly Leu Cys Leu Ala Gly Phe Ser G1n Leu Leu Pro Gly Met Thr <210> 143 <211> 198 <212> PRT
<213> Homo sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:040338.2.orf1:2000MAY01 <400> 143 His His Trp Leu Leu Glu Lys Asp Pro Val Ser Arg Pro Gly Thr Ala Gly Ala Ser Ser Ser Thr Lys Gly Lys Leu Pro Arg Arg Thr Thr Thr Arg Pro Trp Ala Ala Phe Thr Ser Leu Pro Ser Ala Phe Ser Thr Ala Thr Cys Pro Arg Glu Ser Val Pro Gln I1e Pro Pro Ala Arg Arg Gly Ser Arg Ala Arg Pro Pro Pro Gly Val Lys Ser Ala A1a Cys Cys Cys Pro Leu Cys Ser Cys Cys Cys Cys Cys Ser Gly Thr Ala Arg Ser Ser Thr Gly Pro Phe Phe Ser Pro Asp Arg His Ser Gly Pro Gly Arg Leu His Pro Ala Pro Gln Ser Pro Gly Leu Cys His Val Pro Pro Val Val Pro Pro Arg Ala Leu Gly Ser Val Ala Gly Pro Ser Gly Pro Leu Leu Pro Ala Pro Arg Arg G1u Leu Leu Pro Ala Gln Ala Arg Leu Phe Gly Leu Ala Ser Ser Arg Arg Pro Gly Ala Gln Pro Cys Ala Ala Arg Gly Leu Pro Gly Leu Ala Glu Ala Pro Pro Cys Asp Arg Arg Gly Ser Gly Pro Pro Pro Gly Gly Cys <210> 144 <211> 116 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:399174.2.orf2:2000MAY01 <400> 144 Pro Leu Lys Gly Asn Asp Ile Val Thr Gly Arg Gln Glu Pro Arg Gly Gly Ser Pro Val Ser Ser Glu Ser Gln Arg His Leu Ala Phe Pro Leu Gly Asp Gly Arg Trp Ala Val Ser Ser Gly Glu Arg Phe Thr Gln Gly Leu Tyr Gly Gly Val Gly Lys Arg His Phe Asn Val Lys Thr Asn Glu Leu Ala Ser Leu Glu Ile Cys Pro Cys Leu G1n Asp Leu Ser Gly Pro Gly Pro Trp Leu Leu Pro Trp Lys Leu Pro Val Gln Thr Ser Ser Leu Ser Pro Leu Glu Gly Arg Gln Arg Gly Val Cys Glu Leu Asp Val Leu Ser Cys Leu Ser <210> 145 <211> 307 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:197275.5.orf2:2000MAY01 <400> 145 Ser Ala Leu Gln His_Leu Glu Ser Leu Gln Lys Gln Tyr Leu Phe Val Ser Asn Lys Thr Gly Thr Leu His Glu Ala Cys Glu Gln Leu Leu Lys Glu Gln Ser Glu Leu Val Asp Leu Ala Glu Asn I1e Gln Gln Lys Leu Ser Tyr~Phe Asn Glu Leu Glu Thr Ile Asn Thr Lys Leu Asn Ser Pro Thr Leu Ser Val Asn Ser Asp Gly Phe Ile Pro Met Leu Ala Lys Leu Asp Asp Cys Ile Thr Tyr Ile Ser Ser His Pro Asn Phe Lys Asp Tyr Pro Ile Tyr Leu Leu Lys Phe Lys Gln Cys Leu Ser Lys Ala Leu His Leu Met Lys Thr Tyr Thr Val Asn Thr Leu Gln Thr Leu Thr Ser Gln Leu Leu Lys Arg Asp Pro Ser Ser Val Pro Asn Ala Asp Asn Ala Phe Thr Leu Phe Tyr Val Lys Phe Arg Ala Ala A1a Pro Lys Val Arg Thr Leu Ile Glu Gln Ile Glu Leu Arg Ser Glu Lys Tle Pro Glu Tyr Gln Gln Leu Leu Asn Asp Ile His Gln Cys Tyr Leu Asp Gln Arg Glu Leu Leu Leu Gly Pro Ser Ile Ala Cys Thr Val A1a Glu Leu Thr Ser Gln Asn Asn Arg Asp His Cys A1a Leu Va1 Arg Ser Gly Cys Ala Phe Met Val His Val Cys Gln Asp Glu His Gln Leu Tyr Asn Glu Phe Phe Thr Lys Pro Thr Ser Lys Leu Asp Glu Leu Leu Glu Lys Leu Cys Val Ser Leu Tyr Asp Val Phe Arg Pro Leu I1e Ile His Val Ile His Leu G1u Thr Leu Ser Glu Leu Cys Gly Ile Leu Lys Asn Glu Val Leu Lys Ile Met Cys Arg Thr Met Leu Ser Asn Trp Gly His Pro G1n Leu Glu Ser Ser Arg Cys <210> 146 <211> 85 <212> PRT
<213> Homo Sapiens <220>
<221> misc_feature <223> Incyte ID No: LI:336872.1.orf2:2000MAY01 <400> 146 Ser Ser Thr Gly Leu Asp Leu Leu Val Lys Ser Leu His Ser Lys Ala Tyr His Ser Lys Ile Ser Arg Arg Arg Leu Val Pro Cys Thr DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

~~ TTENANT LES PAGES 1 A 224 NOTE : Pour les tomes additionels, veuillez contacter 1e Bureau canadien des brevets JUMBO APPLICATIONS/PATENTS
THIS SECTION OF THE APPLICATION/PATENT CONTAINS MORE THAN ONE
VOLUME

NOTE: For additional volumes, please contact the Canadian Patent Office NOM DU FICHIER / FILE NAME
NOTE POUR LE TOME / VOLUME NOTE:

Claims (26)

What is claimed is:

1. An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of:
a) a polynucleotide sequence selected from the group consisting of SEQ ID NO:
1-79, b) a naturally occurring polynucleotide sequence having at least 90% sequence identity to a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-79, c) a polynucleotide sequence complementary to a), d) a polynucleotide sequence complementary to b), and e) an RNA equivalent of a) through d).

2. An isolated polynucleotide of claim 1, comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:1-79.

3. An isolated polynucleotide comprising at least 60 contiguous nucleotides of a polynucleotide of claim 1.

4. A composition for the detection of expression of secretory polynucleotides comprising at least one of the polynucleotides of claim 1 and a detectable label.

5. A method for detecting a target polynucleotide in a sample, said target polynucleotide having a sequence of a polynucleotide of claim 1, the method comprising:
a) amplifying said target polynucleotide or fragment thereof using polymerase chain reaction amplification, and b) detecting the presence or absence of said amplified target polynucleotide or fragment thereof, and, optionally, if present, the amount thereof.

6. A method for detecting a target polynucleotide in a sample, said target polynucleotide comprising a sequence of a polynucleotide of claim 1, the method comprising:
a) hybridizing the sample with a probe comprising at least 20 contiguous nucleotides comprising a sequence complementary to said target polynucleotide in the sample, and which probe specifically hybridizes to said target polynucleotide, under conditions whereby a hybridization complex is formed between said probe and said target polynucleotide or fragments thereof, and b) detecting the presence or absence of said hybridization complex, and, optionally, if present, the amount thereof.

7. A method of claim 5, wherein the probe comprises at least 30 contiguous nucleotides.

8. A method of claim 5, wherein the probe comprises at least 60 contiguous nucleotides.

9. A recombinant polynucleotide comprising a promoter sequence operably linked to a polynucleotide of claim 1.

10. A cell transformed with a recombinant polynucleotide of claim 9.

11. A transgenic organism comprising a recombinant polynucleotide of claim 9.

12. A method for producing a secretory polypeptide, the method comprising:
a) culturing a cell under conditions suitable for expression of the secretory polypeptide, wherein said cell is transformed with a recombinant polynucleotide of claim 9, and b) recovering the secretory polypeptide so expressed.

13. A purified secretory polypeptide (SPTM) encoded by at least one of the polynucleotides of claim 2.

14. An isolated antibody which specifically binds to a secretory polypeptide of claim 13.

15. A method of identifying a test compound which specifically binds to the secretory polypeptide of claim 13, the method comprising the steps of:
a) providing a test compound;
b) combining the secretory polypeptide with the test compound for a sufficient time and under suitable conditions for binding; and c) detecting binding of the secretory polypeptide to the test compound, thereby identifying the test compound which specifically binds the secretory polypeptide.

16. A microarray wherein at least one element of the microarray is a polynucleotide of claim 3.

17. A method for generating a transcript image of a sample which contains polynucleotides, the method comprising the steps of:
a) labeling the polynucleotides of the sample, b) contacting the elements of the microarray of claim 16 with the labeled polynucleotides of the sample under conditions suitable for the formation of a hybridization complex, and c) quantifying the expression of the polynucleotides in the sample.

18. A method for screening a compound for effectiveness in altering expression of a target polynucleotide, wherein said target polynucleotide comprises a polynucleotide sequence of claim 1, the method comprising:
a) exposing a sample comprising the target polynucleotide to a compound, under conditions suitable for the expression of the target polynucleotide, b) detecting altered expression of the target polynucleotide, and c) comparing the expression of the target polynucleotide in the presence of varying amounts of the compound and in the absence of the compound.

19. A method for assessing toxicity of a test compound, said method comprising:
a) treating a biological sample containing nucleic acids with the test compound;
b) hybridizing the nucleic acids of the treated biological sample with a probe comprising at least 20 contiguous nucleotides of a polynucleotide of claim 1 under conditions whereby a specific hybridization complex is formed between said probe and a target polynucleotide in the biological sample, said target polynucleotide comprising a polynucleotide sequence of a polynucleotide of claim 1 or fragment thereof;
c) quantifying the amount of hybridization complex; and d) comparing the amount of hybridization complex in the treated biological sample with the amount of hybridization complex in an untreated biological sample, wherein a difference in the amount of hybridization complex in the treated biological sample is indicative of toxicity of the test compound.

20. An array comprising different nucleotide molecules affixed in distinct physical locations on a solid substrate, wherein at least one of said nucleotide molecules comprises a first oligonucleotide or polynucleotide sequence specifically hybridizable with at least 30 contiguous nucleotides of a target polynucleotide, said target polynucleotide having a sequence of claim 1.

21. An array of claim 20, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 30 contiguous nucleotides of said target polynucleotide.

22. An array of claim 20, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 60 contiguous nucleotides of said target polynucleotide

23. An array of claim 20, which is a microarray.

24. An array of claim 20, further comprising said target polynucleotide hybridized to said first oligonucleotide or polynucleotide.

25. An array of claim 20, wherein a linker joins at least one of said nucleotide molecules to said solid substrate.

26. An array of claim 20, wherein each distinct physical location on the substrate contains multiple nucleotide molecules having the same sequence, and each distinct physical location on the substrate contains nucleotide molecules having a sequence which differs from the sequence of nucleotide molecules at another physical location on the substrate.