CA2414967C - Valproic acid and derivatives thereof as histone deacetylase inhibitors - Google Patents
Valproic acid and derivatives thereof as histone deacetylase inhibitors Download PDFInfo
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- CA2414967C CA2414967C CA002414967A CA2414967A CA2414967C CA 2414967 C CA2414967 C CA 2414967C CA 002414967 A CA002414967 A CA 002414967A CA 2414967 A CA2414967 A CA 2414967A CA 2414967 C CA2414967 C CA 2414967C
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00114088A EP1170008A1 (en) | 2000-07-07 | 2000-07-07 | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
| EP00114088.8 | 2000-07-07 | ||
| PCT/EP2001/007704 WO2002007722A2 (en) | 2000-07-07 | 2001-07-05 | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
Publications (2)
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| CA2414967A1 CA2414967A1 (en) | 2002-01-31 |
| CA2414967C true CA2414967C (en) | 2009-08-25 |
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| CA002414967A Expired - Fee Related CA2414967C (en) | 2000-07-07 | 2001-07-05 | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
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|---|---|
| US (2) | US7265154B2 (https=) |
| EP (2) | EP1170008A1 (https=) |
| JP (1) | JP2004504347A (https=) |
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| CA (1) | CA2414967C (https=) |
| DE (1) | DE60110912T2 (https=) |
| ES (1) | ES2239677T3 (https=) |
| PT (1) | PT1301184E (https=) |
| WO (1) | WO2002007722A2 (https=) |
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| EP1170008A1 (en) | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
| GB0024362D0 (en) * | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
| WO2003018767A2 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| EP1293205A1 (en) * | 2001-09-18 | 2003-03-19 | G2M Cancer Drugs AG | Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease |
| US6706686B2 (en) | 2001-09-27 | 2004-03-16 | The Regents Of The University Of Colorado | Inhibition of histone deacetylase as a treatment for cardiac hypertrophy |
| AU2002340253C1 (en) | 2001-10-16 | 2011-03-31 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| WO2003075856A2 (en) | 2002-03-07 | 2003-09-18 | University Of Delaware | Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea |
| IL149404A0 (en) * | 2002-04-29 | 2002-11-10 | Yissum Res Dev Co | METHODS AND COMPOSITIONS FOR MODULATING β-CATENIN PHOSPHORYLATION |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| CA2508052A1 (en) * | 2002-12-05 | 2004-06-17 | Imperial College Innovations Limited | Control of apoptosis using a complex of an oligonucleotide and a regulatory peptide |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
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| US6300373B1 (en) * | 1993-09-10 | 2001-10-09 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
| US5672746A (en) * | 1994-08-30 | 1997-09-30 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
| WO1995011699A1 (en) * | 1993-10-29 | 1995-05-04 | The Trustees Of Boston University | Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents |
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| WO1998029114A1 (en) * | 1996-12-30 | 1998-07-09 | Bar-Ilan University | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
| US6387673B1 (en) * | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
| AU1395999A (en) * | 1997-11-10 | 1999-05-31 | Salk Institute For Biological Studies, The | Methods for the use of inhibitors of co-repressors for the treatment of neoplastic diseases |
| US6262116B1 (en) * | 1998-01-23 | 2001-07-17 | Sloan-Kettering Institute For Cancer Research | Transcription therapy for cancers |
| EP1170008A1 (en) | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
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2000
- 2000-07-07 EP EP00114088A patent/EP1170008A1/en not_active Withdrawn
-
2001
- 2001-07-05 WO PCT/EP2001/007704 patent/WO2002007722A2/en not_active Ceased
- 2001-07-05 DE DE60110912T patent/DE60110912T2/de not_active Expired - Lifetime
- 2001-07-05 ES ES01962831T patent/ES2239677T3/es not_active Expired - Lifetime
- 2001-07-05 CA CA002414967A patent/CA2414967C/en not_active Expired - Fee Related
- 2001-07-05 US US10/332,353 patent/US7265154B2/en not_active Expired - Fee Related
- 2001-07-05 AU AU8392501A patent/AU8392501A/xx active Pending
- 2001-07-05 AT AT01962831T patent/ATE295725T1/de active
- 2001-07-05 EP EP01962831A patent/EP1301184B1/en not_active Expired - Lifetime
- 2001-07-05 PT PT01962831T patent/PT1301184E/pt unknown
- 2001-07-05 AU AU2001283925A patent/AU2001283925B2/en not_active Ceased
- 2001-07-05 JP JP2002513458A patent/JP2004504347A/ja not_active Ceased
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2007
- 2007-01-17 US US11/653,855 patent/US20070232696A1/en not_active Abandoned
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|---|---|
| AU8392501A (en) | 2002-02-05 |
| DE60110912D1 (de) | 2005-06-23 |
| PT1301184E (pt) | 2005-07-29 |
| AU2001283925B2 (en) | 2005-07-14 |
| US7265154B2 (en) | 2007-09-04 |
| ATE295725T1 (de) | 2005-06-15 |
| ES2239677T3 (es) | 2005-10-01 |
| US20040087652A1 (en) | 2004-05-06 |
| WO2002007722A2 (en) | 2002-01-31 |
| JP2004504347A (ja) | 2004-02-12 |
| EP1301184B1 (en) | 2005-05-18 |
| DE60110912T2 (de) | 2005-10-20 |
| US20070232696A1 (en) | 2007-10-04 |
| EP1170008A1 (en) | 2002-01-09 |
| WO2002007722A3 (en) | 2002-07-18 |
| EP1301184A2 (en) | 2003-04-16 |
| CA2414967A1 (en) | 2002-01-31 |
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