CA2412197A1 - Compositions de poudre - Google Patents

Compositions de poudre Download PDF

Info

Publication number
CA2412197A1
CA2412197A1 CA002412197A CA2412197A CA2412197A1 CA 2412197 A1 CA2412197 A1 CA 2412197A1 CA 002412197 A CA002412197 A CA 002412197A CA 2412197 A CA2412197 A CA 2412197A CA 2412197 A1 CA2412197 A1 CA 2412197A1
Authority
CA
Canada
Prior art keywords
powder
weight
salt
adjuvant
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002412197A
Other languages
English (en)
Inventor
Yuh-Fun Maa
Lu Zhao
Steven Joseph Prestrelski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Powderject Vaccines Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2412197A1 publication Critical patent/CA2412197A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une poudre fluide formant un gel, pouvant convenir comme vaccin, préparée par séchage par pulvérisation ou par lyophilisation avec pulvérisation d'une suspension aqueuse qui contient : un antigène adsorbé sur un sel d'aluminium ou sur un adjuvant de sel de calcium, un saccharide, un acide aminé ou un sel de celui-ci, et une matière colloïdale. La poudre, destinée à des applications vaccinales, peut aussi être préparée par lyophilisation avec pulvérisation d'une suspension aqueuse d'un tel adjuvant contenant un antigène adsorbé. L'invention concerne aussi des procédés permettant de former ces compositions de poudre, ainsi que des procédés d'utilisation des compositions dans une procédure de vaccination.
CA002412197A 2000-06-08 2001-06-08 Compositions de poudre Abandoned CA2412197A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21058100P 2000-06-08 2000-06-08
US59077700A 2000-06-08 2000-06-08
US60/210,581 2000-06-08
US09/590,777 2000-06-08
PCT/US2001/018494 WO2001093829A2 (fr) 2000-06-08 2001-06-08 Compositions de poudre

Publications (1)

Publication Number Publication Date
CA2412197A1 true CA2412197A1 (fr) 2001-12-13

Family

ID=26905296

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002412197A Abandoned CA2412197A1 (fr) 2000-06-08 2001-06-08 Compositions de poudre

Country Status (11)

Country Link
EP (1) EP1289494A2 (fr)
JP (1) JP2003535119A (fr)
KR (1) KR20030020294A (fr)
CN (1) CN1438874A (fr)
AU (1) AU2001275371B9 (fr)
BR (1) BR0111494A (fr)
CA (1) CA2412197A1 (fr)
IL (1) IL153241A0 (fr)
MX (1) MXPA02012039A (fr)
NZ (2) NZ552576A (fr)
WO (1) WO2001093829A2 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002302814A1 (en) 2001-06-08 2002-12-23 Powderject Vaccines, Inc. Spray freeze-dried compositions
AU2002346424A1 (en) * 2001-11-19 2003-06-10 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
WO2003087339A2 (fr) * 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Lyophilisation par pulverisation de compositions a administration pulmonaire
DE10339197A1 (de) * 2003-08-22 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität
EP1796652A2 (fr) * 2004-09-28 2007-06-20 Alza Corporation Stabilisation d'agents immunologiquement actifs completes d'un adjuvant aluminaire
JP5349043B2 (ja) * 2005-06-27 2013-11-20 アプライド シン フィルムズ，インコーポレイティッド 燐酸アルミニウム系マイクロスフェア
WO2007038926A1 (fr) 2005-10-04 2007-04-12 Alk-Abelló A/S Formulation vaccinale solide
EP1945249A2 (fr) * 2005-11-01 2008-07-23 Novartis AG Compositions comprenant des antigenes adsorbes par du phosphate de calcium
EP2068834A2 (fr) * 2006-09-08 2009-06-17 Becton, Dickinson & Company Formulations en poudre stable de vaccins adsorbés sur hydroxyde d'aluminium
AU2007306936B2 (en) 2006-10-12 2014-02-06 The University Of Queensland Compositions and methods for modulating immune responses
EP2829282B1 (fr) * 2007-03-22 2017-10-25 The Regents of The University of Colorado, A Body Corporate Procédé de préparation d'une composition de vaccin séchée à liaison d'adjuvants immunocompétents
CA2694083A1 (fr) * 2007-07-26 2009-01-29 Sanofi Pasteur Limited Compositions antigene-adjuvant et procedes
CA2716399C (fr) 2008-03-05 2020-07-21 Pierre Chouvenc Procede de stabilisation d'un adjuvant contenant une composition de vaccin
CA2738621C (fr) 2008-10-02 2017-01-31 Pharmathene Inc. Formulation de vaccin contre le charbon et ses utilisations
JP5869553B2 (ja) 2010-03-31 2016-02-24 スタビリテック リミテッド ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤
EP2552410B1 (fr) * 2010-03-31 2018-10-24 Stabilitech Biopharma Ltd Procédé de conservation d'adjuvants d'alun et de vaccins contenant un adjuvant d'alun
CA2795013C (fr) 2010-03-31 2018-10-16 Stabilitech Ltd. Stabilisation de particules virales
BR112013010926A2 (pt) 2010-11-01 2016-08-23 Univ Technology Sidney agentes imunomoduladores e seus usos
WO2012075379A2 (fr) 2010-12-02 2012-06-07 Oncolytics Biotech Inc. Formulations de virus liquides
US9044498B2 (en) 2010-12-02 2015-06-02 Oncolytics Biotech Inc. Lyophilized viral formulations
CN102133396B (zh) * 2011-03-16 2013-10-16 中国人民解放军第三〇二医院 一种疫苗注射剂及其制备方法
US20130309273A1 (en) 2012-05-17 2013-11-21 Kimberly Hassett Thermostable Vaccine Compositions and Methods of Preparing Same
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
US9827303B2 (en) * 2012-03-05 2017-11-28 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Methods and compositions for stabilizing dried biological materials
KR101441539B1 (ko) * 2013-04-01 2014-09-18 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 흡습성이 개선된 접착제 조성물 및 이의 제조방법
CN103641886B (zh) * 2013-11-26 2015-07-29 精晶药业股份有限公司 一种丙谷二肽的精制方法
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
HU188847B (en) * 1983-02-22 1986-05-28 Human Oltoanyagtermeloe Es Kutato Intezet,Hu Process for producing liophylized combined vaccines
JPS6013718A (ja) * 1983-07-05 1985-01-24 Chemo Sero Therapeut Res Inst Ｂ型肝炎ワクチン
JP2749449B2 (ja) * 1992-12-28 1998-05-13 ユー、シイ−チャン 不揮発性半導体メモリセル
JP3583128B2 (ja) * 1993-01-08 2004-10-27 シーエスエル、リミテッド ワクチン製剤
TW404844B (en) * 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
US5902565A (en) * 1993-12-24 1999-05-11 Csl Limited Spray dried vaccine preparation comprising aluminium adsorbed immunogens
RU2096042C1 (ru) * 1996-11-06 1997-11-20 Виктор Иванович Ситьков Способ получения поливалентной вакцины против лептоспироза животных
WO1999027961A1 (fr) * 1997-12-02 1999-06-10 Powderject Vaccines, Inc. Administration transdermique de compositions particulaires de vaccins

Also Published As

Publication number Publication date
CN1438874A (zh) 2003-08-27
NZ552576A (en) 2008-06-30
BR0111494A (pt) 2004-01-13
JP2003535119A (ja) 2003-11-25
IL153241A0 (en) 2003-07-06
AU2001275371B9 (en) 2007-06-07
EP1289494A2 (fr) 2003-03-12
AU7537101A (en) 2001-12-17
AU2001275371B2 (en) 2006-12-21
MXPA02012039A (es) 2003-06-06
WO2001093829A2 (fr) 2001-12-13
WO2001093829A3 (fr) 2002-06-13
NZ523103A (en) 2005-08-26
KR20030020294A (ko) 2003-03-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued