CA2408850A1 - Dosage de fonction plaquettaire et reactif concu a cet effet - Google Patents

Dosage de fonction plaquettaire et reactif concu a cet effet Download PDF

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Publication number
CA2408850A1
CA2408850A1 CA002408850A CA2408850A CA2408850A1 CA 2408850 A1 CA2408850 A1 CA 2408850A1 CA 002408850 A CA002408850 A CA 002408850A CA 2408850 A CA2408850 A CA 2408850A CA 2408850 A1 CA2408850 A1 CA 2408850A1
Authority
CA
Canada
Prior art keywords
ligand
platelet
platelet function
piop
von willebrand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002408850A
Other languages
English (en)
Inventor
Donald E. Mahan
Michael W. Stewart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PharmaNetics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2408850A1 publication Critical patent/CA2408850A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un réactif de dosage d'une fonction plaquettaire, destiné à l'exécution de ce dosage et contenant un mélange de particules magnétiques et non magnétiques. Ce réactif est caractérisé en ce que sur la surface extérieure des particules magnétiques se trouve fixée une certaine quantité d'un premier ligand possédant une affinité pour une interaction directe avec les récepteurs de la glycoprotéine Ib (GP-Ib) sur des plaquettes sanguines, et en ce que sur la surface extérieure des particules non magnétiques se trouve fixée une certaine quantité d'un second ligand possédant une affinité pour une interaction directe avec des récepteurs de GP-Ib sur des plaquettes sanguines, de sorte que l'interaction de l'un des ligands -le premier ou le second- avec le récepteur plaquettaire de GP-Ib, provoque l'activation des plaquettes sanguines afin que celles-ci s'agrègent, le premier et le second ligand pouvant être semblables ou différents. L'invention concerne également un dosage mettant en oeuvre un tel réactif et destiné à produire une évaluation rapide, fiable, du point d'intervention de la fonction plaquettaire.
CA002408850A 2000-05-09 2001-05-09 Dosage de fonction plaquettaire et reactif concu a cet effet Abandoned CA2408850A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20263800P 2000-05-09 2000-05-09
US60/202,638 2000-05-09
PCT/US2001/011760 WO2001086248A2 (fr) 2000-05-09 2001-05-09 Dosage de fonction plaquettaire et reactif concu a cet effet

Publications (1)

Publication Number Publication Date
CA2408850A1 true CA2408850A1 (fr) 2001-11-15

Family

ID=22750704

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002408850A Abandoned CA2408850A1 (fr) 2000-05-09 2001-05-09 Dosage de fonction plaquettaire et reactif concu a cet effet

Country Status (9)

Country Link
EP (1) EP1280931A4 (fr)
JP (1) JP2003532891A (fr)
KR (1) KR20030014219A (fr)
AU (1) AU2001261020A1 (fr)
BR (1) BR0110735A (fr)
CA (1) CA2408850A1 (fr)
MX (1) MXPA02011017A (fr)
NO (1) NO20025300L (fr)
WO (1) WO2001086248A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680177B2 (en) * 2001-12-07 2004-01-20 Cardiovascular Diagnostics, Inc. Low molecular weight heparin assay, system and reagent therefor
JP4078247B2 (ja) * 2003-05-02 2008-04-23 キヤノン株式会社 磁性体−生体物質複合体型構造体、磁性体に対して結合能を有するアミノ酸配列を有するペプチド断片及びその遺伝子、ならびに磁性体−生体物質複合体型構造体の製造方法
US20120021010A1 (en) * 2010-04-29 2012-01-26 University Of Calcutta Antiplatelet agent and methods of using the same
KR101276179B1 (ko) * 2011-08-08 2013-06-18 고려대학교 산학협력단 혈소판 복합기능 검사 장치 및 방법, 이에 구비되는 미세교반칩
US8772040B2 (en) 2012-08-31 2014-07-08 Korea University Research And Business Foundation Apparatus and method of platelet multi-function analysis, and micro stirring chip

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
TW221493B (fr) * 1990-07-10 1994-03-01 Cardiovascular Diagnostics Inc
US5616311A (en) * 1991-01-15 1997-04-01 Hemosphere, Inc. Non-crosslinked protein particles for therapeutic and diagnostic use
US5446132A (en) * 1992-10-01 1995-08-29 The General Hospital Corporation Thrombin-activated platelet protein-2 (TAPP-2)
US5427913A (en) * 1992-12-03 1995-06-27 Alberta Cancer Board Methods for determining platelet function
KR100305306B1 (ko) * 1993-02-17 2001-11-22 존 펑크하우저 건식화학캐스케이드면역분석법및친화도분석법
US5686597A (en) * 1995-06-06 1997-11-11 Incyte Pharmaceuticals, Inc. Thrombin receptor homolog
US5922551A (en) * 1997-03-20 1999-07-13 Accumetrics, Inc. Agglutrimetric platelet binding assays in blood
US6046051A (en) * 1997-06-27 2000-04-04 Hemosense, Inc. Method and device for measuring blood coagulation or lysis by viscosity changes
US5932445A (en) * 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins

Also Published As

Publication number Publication date
NO20025300D0 (no) 2002-11-05
EP1280931A4 (fr) 2005-02-09
AU2001261020A1 (en) 2001-11-20
WO2001086248A3 (fr) 2002-02-28
EP1280931A2 (fr) 2003-02-05
KR20030014219A (ko) 2003-02-15
JP2003532891A (ja) 2003-11-05
WO2001086248A2 (fr) 2001-11-15
NO20025300L (no) 2003-01-07
MXPA02011017A (es) 2004-08-19
BR0110735A (pt) 2007-05-08

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