CA2408103A1 - Tumor activated prodrug compounds and methods of making and using the same - Google Patents
Tumor activated prodrug compounds and methods of making and using the same Download PDFInfo
- Publication number
- CA2408103A1 CA2408103A1 CA002408103A CA2408103A CA2408103A1 CA 2408103 A1 CA2408103 A1 CA 2408103A1 CA 002408103 A CA002408103 A CA 002408103A CA 2408103 A CA2408103 A CA 2408103A CA 2408103 A1 CA2408103 A1 CA 2408103A1
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- Prior art keywords
- prodrug
- prodrug according
- biologically active
- peptide
- leu
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- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20899600P | 2000-06-01 | 2000-06-01 | |
| EP00870130.2 | 2000-06-01 | ||
| US60/208,996 | 2000-06-01 | ||
| EP00870130 | 2000-06-15 | ||
| EP00870306 | 2000-12-18 | ||
| EP00870306.8 | 2000-12-18 | ||
| PCT/EP2001/006106 WO2001091798A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2408103A1 true CA2408103A1 (en) | 2001-12-06 |
Family
ID=27223761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002408103A Abandoned CA2408103A1 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds and methods of making and using the same |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2003534387A (ja) |
| AU (1) | AU2001279630A1 (ja) |
| CA (1) | CA2408103A1 (ja) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10059762B2 (en) | 2009-01-12 | 2018-08-28 | Cytomx Therapeutics, Inc. | Anti-EGFR activatable antibodies |
| US10800850B2 (en) | 2000-10-09 | 2020-10-13 | Cytomx Therapeutics, Inc. | Therapeutic antibodies |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6035009B2 (ja) * | 2007-08-22 | 2016-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| KR101619816B1 (ko) | 2009-01-19 | 2016-05-13 | 한미사이언스 주식회사 | 면역글로불린 Ｆｃ 단편을 포함하는 올리고뉴클레오타이드 결합체 |
| RU2011138951A (ru) * | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
| WO2019091384A1 (en) * | 2017-11-08 | 2019-05-16 | Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. | Conjugates of biomolecule and use thereof |
-
2001
- 2001-05-29 CA CA002408103A patent/CA2408103A1/en not_active Abandoned
- 2001-05-29 JP JP2001587810A patent/JP2003534387A/ja not_active Withdrawn
- 2001-05-29 AU AU2001279630A patent/AU2001279630A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10800850B2 (en) | 2000-10-09 | 2020-10-13 | Cytomx Therapeutics, Inc. | Therapeutic antibodies |
| US10059762B2 (en) | 2009-01-12 | 2018-08-28 | Cytomx Therapeutics, Inc. | Anti-EGFR activatable antibodies |
| US10118961B2 (en) | 2009-01-12 | 2018-11-06 | Cytomx Therapeutics, Inc. | Modified antibody containing the cleavable peptide with the amino acid sequence TGRGPSWV |
| US10875913B2 (en) | 2009-01-12 | 2020-12-29 | Cytomx Therapeutics, Inc. | Methods of treatment using activatable anti-EGFR antibodies |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003534387A (ja) | 2003-11-18 |
| AU2001279630A1 (en) | 2001-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |