CA2408073A1 - Acides nucleiques codant un nouveau regulateur de la signalisation de la proteine g, rgs18, et leurs utilisations - Google Patents

Acides nucleiques codant un nouveau regulateur de la signalisation de la proteine g, rgs18, et leurs utilisations Download PDF

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Publication number
CA2408073A1
CA2408073A1 CA002408073A CA2408073A CA2408073A1 CA 2408073 A1 CA2408073 A1 CA 2408073A1 CA 002408073 A CA002408073 A CA 002408073A CA 2408073 A CA2408073 A CA 2408073A CA 2408073 A1 CA2408073 A1 CA 2408073A1
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CA
Canada
Prior art keywords
seq
polynucleotide sequence
complementary polynucleotide
polypeptide
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002408073A
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English (en)
Inventor
David L. Murray
Alison W. Gagnon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0018833A external-priority patent/GB0018833D0/en
Application filed by Individual filed Critical Individual
Publication of CA2408073A1 publication Critical patent/CA2408073A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des acides nucléiques codant un nouveau régulateur des polypeptides RGS18 de signalisation de la protéine G. Ces polypeptides RGS18 sont abondamment exprimés dans les plaquettes et comprennent un nouveau domaine RGS (domaine RGS18). Elle concerne également des polypeptides RGS18. Elle concerne des moyens servant à détecter des acides nucléiques RGS18 et des polypeptides RGS18. Elle concerne des procédés servant à détecter des activateurs ou des inhibiteurs de ces polypeptides RGS18. Elle concerne enfin des procédés de prévention et/ou de traitement de maladies ou de troubles associés au dysfonctionnement de l'activation des plaquettes.
CA002408073A 2000-04-28 2001-04-26 Acides nucleiques codant un nouveau regulateur de la signalisation de la proteine g, rgs18, et leurs utilisations Abandoned CA2408073A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20078600P 2000-04-28 2000-04-28
US60/200,786 2000-04-28
GB0018833.4 2000-08-02
GB0018833A GB0018833D0 (en) 2000-08-02 2000-08-02 Nucleic acids and uses thereof
PCT/US2001/013540 WO2001083514A2 (fr) 2000-04-28 2001-04-26 Acides nucleiques codant un nouveau regulateur de la signalisation de la proteine g, rgs18, et leurs utilisations

Publications (1)

Publication Number Publication Date
CA2408073A1 true CA2408073A1 (fr) 2001-11-08

Family

ID=26244772

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002408073A Abandoned CA2408073A1 (fr) 2000-04-28 2001-04-26 Acides nucleiques codant un nouveau regulateur de la signalisation de la proteine g, rgs18, et leurs utilisations

Country Status (11)

Country Link
EP (1) EP1292616A2 (fr)
JP (1) JP2003531631A (fr)
KR (1) KR20030064271A (fr)
AU (1) AU2001261054A1 (fr)
BR (1) BR0110417A (fr)
CA (1) CA2408073A1 (fr)
IL (1) IL152498A0 (fr)
MX (1) MXPA02010414A (fr)
NO (1) NO20025149L (fr)
NZ (1) NZ522034A (fr)
WO (1) WO2001083514A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015708D0 (en) * 2000-06-27 2000-08-16 Smithkline Beecham Plc Novel compounds
US7846671B2 (en) 2002-01-28 2010-12-07 Bristol-Myers Squibb Company Methods of screening for agents that modulate the interaction of RGS and Gαq and urinary incontinence

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274362B1 (en) * 1999-02-04 2001-08-14 Millennium Pharmaceuticals, Inc. RGS-containing molecules and uses thereof

Also Published As

Publication number Publication date
JP2003531631A (ja) 2003-10-28
WO2001083514A3 (fr) 2002-09-19
WO2001083514A2 (fr) 2001-11-08
BR0110417A (pt) 2003-06-03
EP1292616A2 (fr) 2003-03-19
AU2001261054A1 (en) 2001-11-12
NO20025149L (no) 2002-12-16
KR20030064271A (ko) 2003-07-31
NO20025149D0 (no) 2002-10-25
NZ522034A (en) 2004-08-27
MXPA02010414A (es) 2003-04-25
IL152498A0 (en) 2003-05-29

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Legal Events

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FZDE Discontinued