CA2407708A1 - A method for isolating salinomycin from fermentation broth - Google Patents
A method for isolating salinomycin from fermentation broth Download PDFInfo
- Publication number
- CA2407708A1 CA2407708A1 CA002407708A CA2407708A CA2407708A1 CA 2407708 A1 CA2407708 A1 CA 2407708A1 CA 002407708 A CA002407708 A CA 002407708A CA 2407708 A CA2407708 A CA 2407708A CA 2407708 A1 CA2407708 A1 CA 2407708A1
- Authority
- CA
- Canada
- Prior art keywords
- fermentation broth
- salinomycin
- isolating
- biomass
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 38
- 230000004151 fermentation Effects 0.000 title claims abstract description 38
- KQXDHUJYNAXLNZ-XQSDOZFQSA-N Salinomycin Chemical compound O1[C@@H]([C@@H](CC)C(O)=O)CC[C@H](C)[C@@H]1[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(C=C[C@@H](O)[C@@]3(O[C@@](C)(CC3)[C@@H]3O[C@@H](C)[C@@](O)(CC)CC3)O2)O1 KQXDHUJYNAXLNZ-XQSDOZFQSA-N 0.000 title claims abstract description 25
- 239000004189 Salinomycin Substances 0.000 title claims abstract description 25
- 229960001548 salinomycin Drugs 0.000 title claims abstract description 25
- 235000019378 salinomycin Nutrition 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000002028 Biomass Substances 0.000 claims abstract description 15
- 239000005909 Kieselgur Substances 0.000 claims abstract description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000012530 fluid Substances 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 235000013312 flour Nutrition 0.000 claims abstract description 5
- 239000008187 granular material Substances 0.000 claims abstract description 5
- 239000002023 wood Substances 0.000 claims abstract description 5
- 239000010457 zeolite Substances 0.000 claims abstract description 5
- 230000002378 acidificating effect Effects 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 239000002245 particle Substances 0.000 claims abstract description 3
- 239000000047 product Substances 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 6
- 241000187759 Streptomyces albus Species 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 229910021536 Zeolite Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000003324 growth hormone secretagogue Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- 239000001692 EU approved anti-caking agent Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000010796 biological waste Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003224 coccidiostatic agent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Processing Of Solid Wastes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Soil Conditioners And Soil-Stabilizing Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SKPV0664-2000 | 2000-05-04 | ||
| SK664-2000A SK283167B6 (sk) | 2000-05-04 | 2000-05-04 | Spôsob izolácie salinomycínu z vyfermentovanej pôdy |
| PCT/SK2001/000015 WO2001083801A2 (en) | 2000-05-04 | 2001-05-03 | A method for isolating salinomycin from fermentation broth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2407708A1 true CA2407708A1 (en) | 2001-11-08 |
Family
ID=20435891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002407708A Abandoned CA2407708A1 (en) | 2000-05-04 | 2001-05-03 | A method for isolating salinomycin from fermentation broth |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU2001255144A1 (sk) |
| BR (1) | BR0110589A (sk) |
| CA (1) | CA2407708A1 (sk) |
| CZ (1) | CZ20023429A3 (sk) |
| DE (1) | DE10196144T1 (sk) |
| SI (1) | SI21043A (sk) |
| SK (1) | SK283167B6 (sk) |
| WO (1) | WO2001083801A2 (sk) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007145857A1 (en) * | 2006-06-13 | 2007-12-21 | Phibro Animal Health Corporation | Method of reducing the growth of lactobacilli in a process of ethanol procuction by yeast fermentation comprising adding a pristinamycin-type antimicrobial agent and/or a polyether ionophore antimicrobial agent in form |
| CN108478536B (zh) * | 2018-03-30 | 2019-02-26 | 内蒙古拜克生物有限公司 | 一种盐霉素造粒方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2353031C2 (de) * | 1972-10-27 | 1985-02-21 | Brevetti Gabbiani S.p.A., Podenzano, Piacenza | Vorrichtung zur Weiterleitung von Gegenständen in einem Winkel, insbesondere für Verarbeitungsstrecken von Plattenelementen |
| US4009262A (en) * | 1975-04-21 | 1977-02-22 | Eli Lilly And Company | Antibiotic a-28086 recovery process |
| JPS53148595A (en) * | 1977-06-01 | 1978-12-25 | Kaken Pharmaceut Co Ltd | Preparation of salinomycines |
| DE3005642A1 (de) * | 1980-02-15 | 1981-08-20 | Hoechst Ag, 6000 Frankfurt | Feststoff der salinomycin-kulturbruehe und verfahren zu seiner gewinnung |
| JPS61247398A (ja) * | 1986-01-21 | 1986-11-04 | Kaken Pharmaceut Co Ltd | サリノマイシン類の製法 |
| YU48437B (sh) * | 1990-12-21 | 1998-07-10 | Hoechst Aktiengesellschaft | Granulat aglomerata biomase salinomicina koji ima dobru sposobnost tečenja, nepraškast je i ima neograničeno biološko iskorišćenje aktivne supstance i postupak za njegovo dobijanje |
-
2000
- 2000-05-04 SK SK664-2000A patent/SK283167B6/sk unknown
-
2001
- 2001-05-03 AU AU2001255144A patent/AU2001255144A1/en not_active Abandoned
- 2001-05-03 WO PCT/SK2001/000015 patent/WO2001083801A2/en not_active Application Discontinuation
- 2001-05-03 SI SI200120024A patent/SI21043A/sl not_active IP Right Cessation
- 2001-05-03 DE DE10196144T patent/DE10196144T1/de not_active Withdrawn
- 2001-05-03 CZ CZ20023429A patent/CZ20023429A3/cs unknown
- 2001-05-03 BR BR0110589-2A patent/BR0110589A/pt not_active IP Right Cessation
- 2001-05-03 CA CA002407708A patent/CA2407708A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0110589A (pt) | 2003-04-01 |
| AU2001255144A1 (en) | 2001-11-12 |
| CZ20023429A3 (cs) | 2003-04-16 |
| SI21043A (sl) | 2003-04-30 |
| SK283167B6 (sk) | 2003-03-04 |
| DE10196144T1 (de) | 2003-04-17 |
| WO2001083801A3 (en) | 2002-06-13 |
| WO2001083801A2 (en) | 2001-11-08 |
| SK6642000A3 (en) | 2002-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |